GNGT1 Gene

Aliases
for GNGT1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC07P092071 GC07P093114 GC07P093147 GC07P093180 GC07P093373 GC07P088143

Summaries
for GNGT1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GNGT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmids (see first 1): GNGT1 promoter sequences (S715398  S715602  S716800)

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNGT1

GNGT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P093220:  view genomic region     (about GC identifiers)

Proteins
for GNGT1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for GNGT1: NX_P63211

Explore proteomics data for GNGT1 at MOPED

Post-translational modifications: 

GNGT1 Human Recombinant Protein Products:

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GNGT1 Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for GNGT1
	antibodies-online kits for GNGT1 (8 products)

Domains /
Families
for GNGT1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P63211

Find genes that share domains with GNGT1           About GenesLikeMe

Function
for GNGT1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 3 alleles) (MGI details for Gngt1)

genOway: Develop your customized and physiologically relevant rodent model for GNGT1

miRNA Products:		miRTarBase miRNAs that target GNGT1: hsa-mir-335-5p (MIRT018996)
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		Predesigned siRNA for gene silencing in human, mouse, rat GNGT1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GNGT1

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNGT1

Localization
for GNGT1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	3
extracellular	2
mitochondrion	1
nucleus	1

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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for GNGT1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for GNGT1 About   (see all 61)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	The phototransduction cascade	The phototransduction cascade 0.51 Inactivation, recovery and regulation of the phototransduction cascade 0.49 Visual signal transduction- Rods 0.51 Activation of the phototransduction cascade 0.00 Phototransduction 0.51
2	ADP signalling through P2Y purinoceptor 12	G-protein beta-gamma signalling 0.90 G-protein activation 0.74 G beta-gamma signalling through PI3Kgamma 0.90 Thrombin signalling through proteinase activated receptors (PARs) 0.69 Signal amplification 0.79 Activation of Kainate Receptors upon glutamate binding 0.68 ADP signalling through P2Y purinoceptor 1 0.79 Inhibition of Insulin Secretion by Adrenaline/Noradrenaline 0.64
3	fMLP Pathway	fMLP Pathway 0.43 Alpha-Adrenergic Signaling 0.38 Signal transduction Activation of PKC via G-Protein coupled receptor 0.42 Huntington's Disease Pathway 0.30
4	Regulation of Water Balance by Renal Aquaporins	Regulation of Water Balance by Renal Aquaporins 0.85 Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation 0.40 Aquaporin-mediated transport 0.85
5	EphB-EphrinB Signaling	EphB-EphrinB Signaling 0.58 Cytoskeleton remodeling Reverse signaling by ephrin B 0.33 Ephrin-Eph Signaling 0.58

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNGT1

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

Selected GeneGo (Thomson Reuters) Pathways for GNGT1

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

5 BioSystems Pathways for GNGT1

	Myometrial Relaxation and Contraction Pathways
	Estrogen signaling pathway
	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell
	Visual signal transduction- Rods

Selected Reactome Pathways for GNGT1

	G alpha (12/13) signalling events
	Inactivation, recovery and regulation of the phototransduction cascade
	G alpha (z) signalling events
	Olfactory Signaling Pathway
	Activation of the phototransduction cascade

Selected Kegg Pathways  (Kegg details for GNGT1)

	Ras signaling pathway
	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Circadian entrainment
	Retrograde endocannabinoid signaling

Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

Drugs & Compounds
for GNGT1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GNGT1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GNGT1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GNGT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TACGTGAATT

About this image

Eye (Sensory Organs)    fully expand to see all 3 entries
nGnG Amacrine Cells Inner Nuclear Layer
Retina
Neurons
nGnG Amacrine Cells Inner Nuclear Layer
Ovary (Reproductive System)

Primer Products:		OriGene qPCR primer pairs and template standards for GNGT1 OriGene qSTAR qPCR primer pairs in human, mouse for GNGT1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNGT1

Orthologs
for GNGT1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GNGT1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GNGT1 gene

GNG11²  GNGT2²  

9 SIMAP similar genes for GNGT1 using alignment to 2 protein entries:     GBG1_HUMAN (see all proteins):

GNG11    GNGT2    GNG12    GNG7    GNG10    GNG2

GNG3    GNG4    GNG8

Find genes that share paralogs with GNGT1           About GenesLikeMe


1 Pseudogenes.org Pseudogene for GNGT1
PGOHUM00000233472

Genomic Variants
for GNGT1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GNGT1 (see all 172)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1802781,2	C,F,A,H	--	93533839(-)	ATTTGG/ACTCCT	1	--	us2k1 tfbs3		15		EA NA WA CSA	588
rs734123791,2	C,F	--	93533870(+)	TAAGTG/TTATCA	1	--	us2k1		3		WA CSA	122
rs1926934031,2		--	93533969(+)	GGAAGC/TACAAC	1	--	us2k1		0	--	--	--	--
rs1409848371,2	C	--	93533999(+)	AACACA/GTGCAA	1	--	us2k1		0	--	--	--	--
rs1841809361,2		--	93534024(+)	CTACAC/TGCCAT	1	--	us2k1		0	--	--	--	--
rs18588271,2	C,F,A,H	--	93534072(-)	GATTTT/GTTGAG	1	--	us2k1		13		NS EA NA WA	778
rs1498366831,2		--	93534130(+)	ACAGGC/TAGGTC	1	--	us2k1		0	--	--	--	--
rs126685921,2	C,H	--	93534205(+)	TATGAA/GAGGGC	1	--	us2k1		0	--	--	--	--
rs1485415551,2		--	93534243(+)	AAACCC/TAACAC	1	--	us2k1		0	--	--	--	--
rs1428632041,2		--	93534288(+)	TCATAA/TCTTTA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for GNGT1 (93220885 - 93470885 bp, first 250kb of GNGT1)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for GNGT1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv511379	CNV	Loss	21212237

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GNGT1

DNA2.0 Custom Variant and Variant Library Synthesis for GNGT1

Disorders / Diseases
for GNGT1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for GNGT1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GNGT1 gene, integrated from 10 sources (see all 38): (articles sorted by number of sources associating them with GNGT1)

Utopia: connect your pdf to the dynamic world of online information

1. Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). (PubMed id 8661128)^{1, 2, 3, 9} Scherer S.W.... Pittler S.J. (Genomics 1996)
2. Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. (PubMed id 8500562)^{1, 2, 9} Tao L.... Fong H.K. (Exp. Eye Res. 1993)
3. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)^{1, 4} Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (Science 2003)
6. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2003)
7. [Analysis of GUCA1B,GNGT1 and RGS9 genes in patients with retinitis pigmentosa]. (PubMed id 15901556)^{1, 4} Zhang Q.J....Guo X.M. (Yi Chuan 2002)
8. IGF-1 activates a cilium-localized noncanonical GI^I^ signaling pathway that regulates cell-cycle progression. (PubMed id 23954591)¹ Yeh C....Sung C.H. (Dev. Cell 2013)
9. The WD40 repeat protein WDR26 binds GI^I^ and promotes GI^I^-dependent signal transduction and leukocyte migration. (PubMed id 22065575)¹ Sun Z....Chen S. (J. Biol. Chem. 2011)
10. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)¹ Fenner B.J....Prehn J.H. (PLoS ONE 2010)

External Searches for GNGT1 gene

Genome Databases showing GNGT1 gene

Other Databases showing GNGT1 gene

Specialized Databases showing GNGT1 gene

Products
for GNGT1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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