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Aliases for GNGT1 Gene

Aliases for GNGT1 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 1 2 3
  • Transducin Gamma Chain 3 4
  • Guanine Nucleotide-Binding Protein G(T) Subunit Gamma-T1 3
  • GNG1 3

External Ids for GNGT1 Gene

Previous GeneCards Identifiers for GNGT1 Gene

  • GC07P092071
  • GC07P093114
  • GC07P093147
  • GC07P093180
  • GC07P093373
  • GC07P088143
  • GC07P093220

Summaries for GNGT1 Gene

Entrez Gene Summary for GNGT1 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GNGT1 Gene

GNGT1 (Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG11.

UniProtKB/Swiss-Prot for GNGT1 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNGT1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNGT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNGT1 Gene

Genomics for GNGT1 Gene

Regulatory Elements for GNGT1 Gene

Genomic Location for GNGT1 Gene

Start:
93,591,573 bp from pter
End:
93,911,265 bp from pter
Size:
319,693 bases
Orientation:
Plus strand

Genomic View for GNGT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNGT1 Gene

Proteins for GNGT1 Gene

  • Protein details for GNGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63211-GBG1_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(T) subunit gamma-T1
    Protein Accession:
    P63211
    Secondary Accessions:
    • A4D1H2
    • O43835
    • Q08447
    • Q16026
    • Q6LCP6

    Protein attributes for GNGT1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8496 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNGT1 Gene

Proteomics data for GNGT1 Gene at MOPED

Post-translational modifications for GNGT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNGT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNGT1 Gene

Domains for GNGT1 Gene

Protein Domains for GNGT1 Gene

Suggested Antigen Peptide Sequences for GNGT1 Gene

Graphical View of Domain Structure for InterPro Entry

P63211

UniProtKB/Swiss-Prot:

GBG1_HUMAN :
  • P63211
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNGT1: view

No data available for Gene Families for GNGT1 Gene

Function for GNGT1 Gene

Molecular function for GNGT1 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),gamma 1 subunit,retinal rod phosphoreceptor
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8661128
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GNGT1: view

Phenotypes for GNGT1 Gene

genes like me logo Genes that share phenotypes with GNGT1: view

Animal Models for GNGT1 Gene

MGI Knock Outs for GNGT1:

Animal Model Products

miRNA for GNGT1 Gene

miRTarBase miRNAs that target GNGT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNGT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNGT1 Gene

Localization for GNGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNGT1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNGT1 Gene COMPARTMENTS Subcellular localization image for GNGT1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment --
GO:0001917 photoreceptor inner segment IEA --
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GNGT1: view

Pathways for GNGT1 Gene

SuperPathways for GNGT1 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 The phototransduction cascade
genes like me logo Genes that share pathways with GNGT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction NAS 8661128
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007268 synaptic transmission TAS --
GO:0007602 phototransduction --
genes like me logo Genes that share ontologies with GNGT1: view

Compounds for GNGT1 Gene

(5) Tocris Compounds for GNGT1 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNGT1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for GNGT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
FARNESYL
target

(1) Novoseek inferred chemical compound relationships for GNGT1 Gene

Compound -log(P) Hits PubMed IDs
metarhodopsin ii 78.9 1
genes like me logo Genes that share compounds with GNGT1: view

Transcripts for GNGT1 Gene

Unigene Clusters for GNGT1 Gene

Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNGT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNGT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3: -

Relevant External Links for GNGT1 Gene

GeneLoc Exon Structure for
GNGT1
ECgene alternative splicing isoforms for
GNGT1

Expression for GNGT1 Gene

mRNA expression in normal human tissues for GNGT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNGT1 Gene

This gene is overexpressed in Kidney - Cortex (14.0), Ovary (12.2), Bladder (7.5), and Testis (6.6).

Protein differential expression in normal tissues for GNGT1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNGT1 Gene

SOURCE GeneReport for Unigene cluster for GNGT1 Gene Hs.732212

mRNA Expression by UniProt/SwissProt for GNGT1 Gene

P63211-GBG1_HUMAN
Tissue specificity: Retinal rod outer segment
genes like me logo Genes that share expressions with GNGT1: view

Expression partners for GNGT1 Gene

In Situ Assay Products

Orthologs for GNGT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNGT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNGT1 35
  • 93.69 (n)
  • 98.65 (a)
GNGT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNGT1 35
  • 94.59 (n)
  • 100 (a)
GNGT1 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gngt1 35
  • 87.39 (n)
  • 97.3 (a)
Gngt1 16
Gngt1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNGT1 35
  • 99.55 (n)
  • 100 (a)
GNGT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gngt1 35
  • 88.29 (n)
  • 94.59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gngt1 35
  • 77.63 (n)
  • 84.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17547 35
zebrafish
(Danio rerio)
Actinopterygii gngt1 35
  • 71.3 (n)
  • 68.06 (a)
gngt1 36
  • 66 (a)
OneToMany
Species with no ortholog for GNGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNGT1 Gene

ENSEMBL:
Gene Tree for GNGT1 (if available)
TreeFam:
Gene Tree for GNGT1 (if available)

Paralogs for GNGT1 Gene

Paralogs for GNGT1 Gene

Selected SIMAP similar genes for GNGT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GNGT1 Gene

genes like me logo Genes that share paralogs with GNGT1: view

Variants for GNGT1 Gene

Sequence variations from dbSNP and Humsavar for GNGT1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2798 -- 93,911,036(-) CTATA(A/C/G/T)ATTTA utr-variant-3-prime
rs180267 -- 93,911,230(-) AGTGA(A/G)AAAAC downstream-variant-500B
rs180269 -- 93,910,215(-) TTTAG(A/T)GCTCA intron-variant
rs180270 -- 93,910,178(-) TCATG(A/T)TGTTT intron-variant
rs180271 -- 93,910,167(-) TTGAG(C/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNGT1 Gene

Variant ID Type Subtype PubMed ID
nsv511379 CNV Loss 21212237

Relevant External Links for GNGT1 Gene

HapMap Linkage Disequilibrium report
GNGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNGT1 Gene

Disorders for GNGT1 Gene

Relevant External Links for GNGT1

Genetic Association Database (GAD)
GNGT1
Human Genome Epidemiology (HuGE) Navigator
GNGT1

No disorders were found for GNGT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GNGT1 Gene

Publications for GNGT1 Gene

  1. Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). (PMID: 8661128) Scherer S.W. … Pittler S.J. (Genomics 1996) 2 3 4 23
  2. Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. (PMID: 8500562) Tao L. … Fong H.K. (Exp. Eye Res. 1993) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. [Analysis of GUCA1B,GNGT1 and RGS9 genes in patients with retinitis pigmentosa]. (PMID: 15901556) Zhang Q.J. … Guo X.M. (Yi Chuan 2002) 3 48
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for GNGT1 Gene

Sources for GNGT1 Gene

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