Aliases for GNGT1 Gene
External Ids for GNGT1 Gene
Previous GeneCards Identifiers for GNGT1 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GNGT1 Gene
GNGT1 (Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 1) is a Protein Coding gene. Diseases associated with GNGT1 include fructose-1,6-bisphosphatase deficiency and retinitis pigmentosa. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG11.
UniProtKB/Swiss-Prot for GNGT1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.