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Aliases for GNG8 Gene

Aliases for GNG8 Gene

  • G Protein Subunit Gamma 8 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 8 2 3 5
  • Gamma-9 3 4
  • GNGT9 4
  • GNG9 4

External Ids for GNG8 Gene

Previous GeneCards Identifiers for GNG8 Gene

  • GC19M047781
  • GC19M047528
  • GC19M051813
  • GC19M051829
  • GC19M047137
  • GC19M043562

Summaries for GNG8 Gene

GeneCards Summary for GNG8 Gene

GNG8 (G Protein Subunit Gamma 8) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG8 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG8 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG8 Gene

Genomics for GNG8 Gene

Regulatory Elements for GNG8 Gene

Promoters for GNG8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNG8 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNG8 Gene

Chromosome:
19
Start:
46,633,934 bp from pter
End:
46,635,534 bp from pter
Size:
1,601 bases
Orientation:
Minus strand

Genomic View for GNG8 Gene

Genes around GNG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG8 Gene

Proteins for GNG8 Gene

  • Protein details for GNG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK08-GBG8_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Protein Accession:
    Q9UK08
    Secondary Accessions:
    • Q4VBM5

    Protein attributes for GNG8 Gene

    Size:
    70 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG8 Gene

Proteomics data for GNG8 Gene at MOPED

Post-translational modifications for GNG8 Gene

No Post-translational modifications

Other Protein References for GNG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG8 Gene

Domains & Families for GNG8 Gene

Protein Domains for GNG8 Gene

Suggested Antigen Peptide Sequences for GNG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK08

UniProtKB/Swiss-Prot:

GBG8_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG8: view

No data available for Gene Families for GNG8 Gene

Function for GNG8 Gene

Molecular function for GNG8 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA,NAS 10819326
genes like me logo Genes that share ontologies with GNG8: view
genes like me logo Genes that share phenotypes with GNG8: view

Animal Models for GNG8 Gene

MGI Knock Outs for GNG8:

Animal Model Products

miRNA for GNG8 Gene

miRTarBase miRNAs that target GNG8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG8 Gene

Localization for GNG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG8 Gene COMPARTMENTS Subcellular localization image for GNG8 gene
Compartment Confidence
plasma membrane 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for GNG8 Gene

Pathways & Interactions for GNG8 Gene

genes like me logo Genes that share pathways with GNG8: view

Gene Ontology (GO) - Biological Process for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 10819326
GO:0007399 nervous system development IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG8: view

No data available for SIGNOR curated interactions for GNG8 Gene

Drugs & Compounds for GNG8 Gene

(3) Drugs for GNG8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG8 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG8: view

Transcripts for GNG8 Gene

mRNA/cDNA for GNG8 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG8 Gene

Guanine nucleotide binding protein (G protein), gamma 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG8 Gene

No ASD Table

Relevant External Links for GNG8 Gene

GeneLoc Exon Structure for
GNG8
ECgene alternative splicing isoforms for
GNG8

Expression for GNG8 Gene

mRNA expression in normal human tissues for GNG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG8 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for GNG8 Gene

This gene is overexpressed in Fetal Brain (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG8 Gene



SOURCE GeneReport for Unigene cluster for GNG8 Gene Hs.283961

genes like me logo Genes that share expression patterns with GNG8: view

Protein tissue co-expression partners for GNG8 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG8 Gene

Orthologs for GNG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG8 35
  • 91.43 (n)
  • 100 (a)
GNG8 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng8 35
  • 88.1 (n)
  • 98.57 (a)
Gng8 16
Gng8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng8 35
  • 87.62 (n)
  • 98.57 (a)
dog
(Canis familiaris)
Mammalia GNG8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG8 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNG8 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng8 35
  • 65.71 (n)
  • 65.71 (a)
zebrafish
(Danio rerio)
Actinopterygii gng8 35
  • 70.95 (n)
  • 80 (a)
gng8 36
  • 80 (a)
OneToOne
Species with no ortholog for GNG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG8 Gene

ENSEMBL:
Gene Tree for GNG8 (if available)
TreeFam:
Gene Tree for GNG8 (if available)

Paralogs for GNG8 Gene

Paralogs for GNG8 Gene

(10) SIMAP similar genes for GNG8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG8: view

Variants for GNG8 Gene

Sequence variations from dbSNP and Humsavar for GNG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1566172 -- 46,633,679(+) AGGGG(C/G/T)TCAGG downstream-variant-500B
rs968394 -- 46,634,785(+) GCCCC(A/G)GTAAC intron-variant, upstream-variant-2KB
rs1874722 -- 46,634,545(+) AGCCC(C/G)GGACA intron-variant
rs1005774 -- 46,633,905(-) TAGGG(G/T)TGGAC downstream-variant-500B
rs2173284 -- 46,633,589(+) GAGTC(A/G)TTAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GNG8 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294

Variation tolerance for GNG8 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG8 Gene

HapMap Linkage Disequilibrium report
GNG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG8 Gene

Disorders for GNG8 Gene

Relevant External Links for GNG8

Genetic Association Database (GAD)
GNG8
Human Genome Epidemiology (HuGE) Navigator
GNG8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG8

No disorders were found for GNG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG8 Gene

Publications for GNG8 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 2 3 4 67
  2. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. (PMID: 23773523) El-Haibi C.P. … Lillard J.W. (Mol. Cancer 2013) 3
  3. The GI^3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. (PMID: 22940628) Sun Z. … Chen S. (Cell. Signal. 2012) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PMID: 19376773) Howlett A.C. … Willardson B.M. (J. Biol. Chem. 2009) 3

Products for GNG8 Gene

Sources for GNG8 Gene

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