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Aliases for GNG8 Gene

Aliases for GNG8 Gene

  • G Protein Subunit Gamma 8 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 8 2 3
  • Gamma-9 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-8 3
  • GNGT9 4
  • GNG9 4

External Ids for GNG8 Gene

Previous GeneCards Identifiers for GNG8 Gene

  • GC19M047781
  • GC19M047528
  • GC19M051813
  • GC19M051829
  • GC19M047137
  • GC19M043562

Summaries for GNG8 Gene

GeneCards Summary for GNG8 Gene

GNG8 (G Protein Subunit Gamma 8) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot for GNG8 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG8 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG8 Gene

Genomics for GNG8 Gene

Regulatory Elements for GNG8 Gene

Enhancers for GNG8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G046727 1.8 FANTOM5 Ensembl ENCODE 11.3 -95.8 -95825 6.9 MLX DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 SSRP1 GLIS1 ZC3H4 ENSG00000268810 CCDC61 BICRA PRKD2 STRN4 ENSG00000259605 IRF2BP1 ENSG00000268746 MIR320E
GH19G046600 1.4 ENCODE dbSUPER 12.3 +33.1 33140 4.6 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 ZC3H4 IRF2BP1 ENSG00000268810 CCDC61 PPP5D1 ENSG00000269148 FBXO46 DM1-AS CCDC9 GNG8
GH19G046658 1.3 ENCODE dbSUPER 13.1 -25.1 -25131 4.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZC3H4 BICRA GNG8 ENSG00000268746 PRKD2 ENSG00000268810 INAFM1 STRN4 DACT3-AS1 DACT3
GH19G046759 1.2 Ensembl ENCODE 10.9 -125.6 -125631 3.8 HDGF ARID4B TCF12 SLC30A9 ZNF121 GATA2 ZNF143 MXD4 PPARG TBX21 STRN4 SLC1A5 PRKD2 MIR320E AP2S1 GNG8 ARHGAP35 TMEM160 FKRP PIR51442
GH19G046546 1.2 Ensembl ENCODE 10.9 +88.8 88807 1.1 HDGF ATF1 CREB3L1 ZFP64 YY1 ETS1 ZNF143 YY2 NFYC REST GNG8 LOC101928145 GAPDHP38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNG8 on UCSC Golden Path with GeneCards custom track

Promoters for GNG8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110402 1134 401 HDAC1 PKNOX1 KLF17 SIN3A GLIS2 SCRT2 KLF13 SP3 ZBTB2 ZNF398

Genomic Location for GNG8 Gene

Chromosome:
19
Start:
46,633,934 bp from pter
End:
46,635,534 bp from pter
Size:
1,601 bases
Orientation:
Minus strand

Genomic View for GNG8 Gene

Genes around GNG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG8 Gene

Proteins for GNG8 Gene

  • Protein details for GNG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK08-GBG8_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Protein Accession:
    Q9UK08
    Secondary Accessions:
    • Q4VBM5

    Protein attributes for GNG8 Gene

    Size:
    70 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG8 Gene

Post-translational modifications for GNG8 Gene

No Post-translational modifications

Other Protein References for GNG8 Gene

No data available for DME Specific Peptides for GNG8 Gene

Domains & Families for GNG8 Gene

Gene Families for GNG8 Gene

Protein Domains for GNG8 Gene

Suggested Antigen Peptide Sequences for GNG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK08

UniProtKB/Swiss-Prot:

GBG8_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG8: view

Function for GNG8 Gene

Molecular function for GNG8 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0004871 signal transducer activity NAS 10819326
GO:0005515 protein binding IPI 23773523
genes like me logo Genes that share ontologies with GNG8: view
genes like me logo Genes that share phenotypes with GNG8: view

Animal Models for GNG8 Gene

MGI Knock Outs for GNG8:

Animal Model Products

CRISPR Products

miRNA for GNG8 Gene

miRTarBase miRNAs that target GNG8

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG8
  • Applied Biological Materials Clones for GNG8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG8 Gene

Localization for GNG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG8 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GNG8: view

Pathways & Interactions for GNG8 Gene

genes like me logo Genes that share pathways with GNG8: view

Gene Ontology (GO) - Biological Process for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10819326
GO:0007399 nervous system development IEA --
GO:0035176 social behavior IEA --
GO:0043584 nose development IEA --
genes like me logo Genes that share ontologies with GNG8: view

No data available for SIGNOR curated interactions for GNG8 Gene

Drugs & Compounds for GNG8 Gene

(3) Drugs for GNG8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNG8 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNG8: view

Transcripts for GNG8 Gene

mRNA/cDNA for GNG8 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG8 Gene

Guanine nucleotide binding protein (G protein), gamma 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG8
  • Applied Biological Materials Clones for GNG8

Alternative Splicing Database (ASD) splice patterns (SP) for GNG8 Gene

No ASD Table

Relevant External Links for GNG8 Gene

GeneLoc Exon Structure for
GNG8
ECgene alternative splicing isoforms for
GNG8

Expression for GNG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG8 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for GNG8 Gene

This gene is overexpressed in Fetal Brain (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG8 Gene



Protein tissue co-expression partners for GNG8 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNG8 Gene:

GNG8

SOURCE GeneReport for Unigene cluster for GNG8 Gene:

Hs.283961

Evidence on tissue expression from TISSUES for GNG8 Gene

  • Blood(2.3)
genes like me logo Genes that share expression patterns with GNG8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG8 Gene

Orthologs for GNG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GNG8 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG8 34 35
  • 91.43 (n)
mouse
(Mus musculus)
Mammalia Gng8 34 16 35
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Gng8 34
  • 87.62 (n)
oppossum
(Monodelphis domestica)
Mammalia GNG8 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNG8 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng8 34
  • 65.71 (n)
zebrafish
(Danio rerio)
Actinopterygii gng8 34 35
  • 70.95 (n)
Species where no ortholog for GNG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG8 Gene

ENSEMBL:
Gene Tree for GNG8 (if available)
TreeFam:
Gene Tree for GNG8 (if available)

Paralogs for GNG8 Gene

Paralogs for GNG8 Gene

(10) SIMAP similar genes for GNG8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG8: view

Variants for GNG8 Gene

Sequence variations from dbSNP and Humsavar for GNG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000142200 -- 46,639,323(+) GGACC(A/T)GGAGA upstream-variant-2KB, utr-variant-5-prime
rs1000747480 -- 46,638,042(+) TCTCT(C/G)TCACA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000961931 -- 46,636,951(+) CACGC(C/T)CGTCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001158588 -- 46,638,285(+) TCACA(C/T)ACAGT intron-variant, utr-variant-5-prime
rs1001851255 -- 46,635,910(+) AGACG(A/G)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNG8 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV loss 17160897
nsv953589 CNV deletion 24416366

Variation tolerance for GNG8 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG8 Gene

Disorders for GNG8 Gene

Relevant External Links for GNG8

Genetic Association Database (GAD)
GNG8
Human Genome Epidemiology (HuGE) Navigator
GNG8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG8

No disorders were found for GNG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG8 Gene

Publications for GNG8 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. (PMID: 23773523) El-Haibi C.P. … Lillard J.W. (Mol. Cancer 2013) 3 64
  5. The GI^3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. (PMID: 22940628) Sun Z. … Chen S. (Cell. Signal. 2012) 3 64

Products for GNG8 Gene

Sources for GNG8 Gene

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