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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNG8 Gene

protein-coding GIFtS: 50
GCID: GC19M047137

guanine nucleotide binding protein (G protein), gamma 8

Explore 5 diseases affiliated with
GNG8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 8¹ ²
Gamma-9³
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-8²
GNG9³
GNGT9³
Gamma-9³

External Ids:	HGNC: 19664¹	Entrez Gene: 94235²	Ensembl: ENSG00000167414⁷	UniProtKB: Q9UK08³

Export aliases for GNG8 gene to outside databases

Previous GC identifers: GC19M047781 GC19M047528 GC19M051813 GC19M051829 GC19M043562

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GBG8_HUMAN, Q9UK08

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

summary for GNG8:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; in addition, some

Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and

Gbetagamma coupled to M1 receptors can activate KIR channels.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNG8 gene promoter:
MEF-2 AP-2gamma Gfi-1 c-Ets-1 MEF-2A PPAR-gamma1 SEF-1 (1) PPAR-gamma2 aMEF-2 ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNG8 promoter sequence

Search SABiosciences Chromatin IP Primers for GNG8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

GNG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG8 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M047137: view genomic region (about GC identifiers)

Start:	47,137,333 bp from pter	End:	47,137,939 bp from pter
Size:	607 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBG8_HUMAN, Q9UK08 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 precursor

Size: 70 amino acids; 7841 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Secondary accessions: Q4VBM5

Explore the universe of human proteins at neXtProt for GNG8: NX_Q9UK08

GNG8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_150283.1

ENSEMBL proteins:

ENSP00000300873

Reactome Protein details: Q9UK08
Human Recombinant Protein Products for GNG8:

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005834	heterotrimeric G-protein complex	IEA	--
GO:0005886	plasma membrane	TAS	--

GNG8 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNG8 for domains About GeneDecksing

2 InterPro domains/families:

IPR001770 Gprotein-gamma

IPR015898 G-protein_gamma-like_dom

Graphical View of Domain Structure for InterPro Entry Q9UK08

ProtoNet protein and cluster: Q9UK08

1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature

UniProtKB/Swiss-Prot: GBG8_HUMAN, Q9UK08

Similarity: Belongs to the G protein gamma family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GBG8_HUMAN, Q9UK08

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	NAS	10819326
GO:0004871	signal transducer activity	NAS	10819326

GNG8 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GNG8:

Decreased Wnt reporter activit

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GNG8

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GNG8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/60 super-pathways (see all 60) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

8/12 pathways (see all 12)
G beta:gamma signalling through PLC beta	1.00	G beta:gamma signalling through PI3Kgamma	0.61
Presynaptic function of Kainate receptors	0.95	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.55
Prostacyclin signalling through prostacyclin receptor	0.77	G-protein activation	0.55
G-protein beta:gamma signalling	0.71	Glucagon-type ligand receptors	0.52

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/31 EMD Millipore Pathways for GNG8 (see all 31)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling

5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG8 (see all 47)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

5/34 GeneGo (Thomson Reuters) Pathways for GNG8 (see all 34)

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

3 BioSystems Pathways for GNG8

	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell

5/48 Reactome Pathways for GNG8 (see all 48)

	G alpha (12/13) signalling events
	Platelet homeostasis
	G protein gated Potassium channels
	G alpha (z) signalling events
	Inwardly rectifying K+ channels

3 Kegg Pathways (Kegg details for GNG8):

	Chemokine signaling pathway
	Glutamatergic synapse
	Cholinergic synapse

GNG8 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNG8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for GNG8 (ENSP00000300873⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY8	ENSP00000286355⁴	STRING: ENSP00000286355
GNG11	ENSP00000248564⁴	STRING: ENSP00000248564
GNG7	ENSP00000371594⁴	STRING: ENSP00000371594
GNGT2	ENSP00000300406⁴	STRING: ENSP00000300406

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006184	GTP catabolic process	NAS	10819326
GO:0007186	G-protein coupled receptor signaling pathway	NAS	10819326
GO:0007268	synaptic transmission	TAS	--
GO:0007399	nervous system development	IEA	--

GNG8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNG8 available from Tocris Bioscience About this table

Compound	Action	CAS #
Gallein	Inhibitor of betagamma signaling	[2103-64-2]
GRK2i	GRK2 inhibitory polypeptide. Gbetagamma antagonist	[148505-03-7]

3 HMDB Compounds for GNG8 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNG8 / GBG8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNG8 gene:

NM_033258.1

Unigene Cluster for GNG8:

Guanine nucleotide binding protein (G protein), gamma 8

Hs.283961

Unigene Representative Sequence: CB565924

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000300873(uc010xyd.2)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG8
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG8

Additional cDNA sequence:

AF493875.1 BC095514.1

1 DOTS entry:

DT.97805627

3 AceView cDNA sequences:

NM_033258 AF493875 CB565924

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNG8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAAGATGA

About this image

GNG8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

N2/LSB/S/F8-induced cells (Generation of midbra...)

Primitive gut tube-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNG8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNG8

SOURCE GeneReport for Unigene cluster: Hs.283961

SABiosciences Custom PCR Arrays for GNG8

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG8

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GNG8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GNG8 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gng8^{1 , 5}	guanine nucleotide binding protein (G protein), gamma more^{1, 5}	88.1(n)¹ 98.57(a)¹		7 (9.15 cM)⁵ 14709¹ NM_010320.3¹ NP_034450.1¹ 16891786⁵
lizard (Anolis carolinensis)	Reptilia	GNG8⁶	--	86(a)	1 ↔ 1	GL343568.1(433554-435193)
zebrafish (Danio rerio)	Actinopterygii	gng8¹	guanine nucleotide binding protein (G protein), gamma more	70.95(n) 80(a)		553609 NM_001177743.2 NP_001171214.1

ENSEMBL Gene Tree for GNG8 (if available)
TreeFam Gene Tree for GNG8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNG8 gene

GNG2² GNG7² GNG10² GNG3² GNG5² GNG5P2² GNG4² GNG12²

11 SIMAP similar genes for GNG8 using alignment to 1 protein entry: GBG8_HUMAN:

GNG2 GNG4 GNG3 GNG7 DKFZp762E193 GNG12

GNG5 GNG10 GNG11 GNGT2 GNGT1

GNG8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2173284^1,2	C,F,A,H	--	47136846(+)	`GAGTCG/ATTAAG`	1	--	ds500¹		17		NS EA NA CSA WA	1734
rs11083842^1,2	C,A,H	--	47136875(+)	`TGGGGA/TCTGGG`	1	--	ds500¹		2		NA	124
rs1566172^1,2	C,F,A	--	47136936(+)	`AGGGGT/CTCAGG`	1	--	ds500¹		10		NA WA EA	496
rs187288215^1,2		--	47136949(+)	`GCACTA/GGAGTA`	1	--	ds500¹		0	--	--	--	--
rs145188588^1,2		--	47137109(+)	`AGCACA/CGAATA`	1	--	ds500¹		0	--	--	--	--
rs1005774^1,2	C,F,A,H	--	47137162(-)	`TAGGGT/GTGGAC`	1	--	ds500¹		29		MN NS EA NA WA CSA	2664
rs12974613^1,2	C,F,H	--	47137459(+)	`TGCGAC/TACCTG`	2	V	syn¹		22		NS EA NA WA EU	6680
rs201179851^1,2		--	47137475(+)	`ACCCGA/GGTGGA`	1	--	int¹		0	--	--	--	--
rs3833245^1,2	C	--	47137482(+)	`TGGAGAT/-GTCAC`	1	--	int¹		1		CSA	2
rs11083843^1,2	C,F	--	47137632(+)	`CCCCGC/ACCCTC`	1	--	int¹		4		NA	126

HapMap Linkage Disequilibrium report for GNG8 (47137333 - 47137939 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GNG8: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG8

DNA2.0 Custom Variant and Variant Library Synthesis for GNG8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNG8 for disorders About GeneDecksing

5 diseases for GNG8: About MalaCards

burkitt's lymphoma tuberculosis huntington's disease colorectal cancer

breast cancer

Human Genome Epidemiology (HuGE) Navigator: GNG8 (3 documents)

Export disorders for GNG8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GNG8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GNG8)

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Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PubMed id 10819326)^{1, 2, 3} Hurowitz E.H....Shizuya H. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)¹ Howlett A.C....Willardson B.M. (2009)
Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)¹ Fowler C.E....Slesinger P.A. (2007)
Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. (PubMed id 12486123)¹ Cuello F....Wieland T. (2003)
The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. (PubMed id 12782285)¹ Rosskopf D....Siffert W. (2003)
Glucagon and regulation of glucose metabolism. (PubMed id 12626323)¹ Jiang G. and Zhang B.B. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94235	HGNC: 19664	AceView: GNG8	Ensembl:ENSG00000167414	euGenes: HUgn94235
ECgene: GNG8	Kegg: 94235	H-InvDB: GNG8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GNG8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNG8 gene
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Patent Information for GNG8 gene:
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GNG8 Gene

guanine nucleotide binding protein (G protein), gamma 8

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GNG8 Gene

guanine nucleotide binding protein (G protein), gamma 8

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