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Aliases for GNG8 Gene

Aliases for GNG8 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 8 2 3
  • Gamma-9 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-8 3
  • GNGT9 4
  • GNG9 4

External Ids for GNG8 Gene

Previous GeneCards Identifiers for GNG8 Gene

  • GC19M047781
  • GC19M047528
  • GC19M051813
  • GC19M051829
  • GC19M047137
  • GC19M043562

Summaries for GNG8 Gene

GeneCards Summary for GNG8 Gene

GNG8 (Guanine Nucleotide Binding Protein (G Protein), Gamma 8) is a Protein Coding gene. Diseases associated with GNG8 include pertussis. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG8 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG8 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG8 Gene

Genomics for GNG8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG8 Gene

Start:
46,634,076 bp from pter
End:
46,634,685 bp from pter
Size:
610 bases
Orientation:
Minus strand

Genomic View for GNG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG8 Gene

Proteins for GNG8 Gene

  • Protein details for GNG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK08-GBG8_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Protein Accession:
    Q9UK08
    Secondary Accessions:
    • Q4VBM5

    Protein attributes for GNG8 Gene

    Size:
    70 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG8 Gene

Proteomics data for GNG8 Gene at MOPED

Post-translational modifications for GNG8 Gene

No Post-translational modifications

Other Protein References for GNG8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG8 Gene

Domains for GNG8 Gene

Protein Domains for GNG8 Gene

Suggested Antigen Peptide Sequences for GNG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK08

UniProtKB/Swiss-Prot:

GBG8_HUMAN :
  • Q9UK08
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG8: view

No data available for Gene Families for GNG8 Gene

Function for GNG8 Gene

Molecular function for GNG8 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0004871 signal transducer activity NAS 10819326
GO:0005515 protein binding IPI 23773523
genes like me logo Genes that share ontologies with GNG8: view

Phenotypes for GNG8 Gene

GenomeRNAi human phenotypes for GNG8:
genes like me logo Genes that share phenotypes with GNG8: view

Animal Model Products

CRISPR Products

miRNA for GNG8 Gene

miRTarBase miRNAs that target GNG8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNG8 Gene

Localization for GNG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG8 Gene COMPARTMENTS Subcellular localization image for GNG8 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG8: view

Pathways for GNG8 Gene

SuperPathways for GNG8 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG8: view

Gene Ontology (GO) - Biological Process for GNG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10819326
GO:0007268 synaptic transmission TAS --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with GNG8: view

Compounds for GNG8 Gene

(5) Tocris Compounds for GNG8 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG8 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG8: view

Transcripts for GNG8 Gene

mRNA/cDNA for GNG8 Gene

(3) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG8 Gene

Guanine nucleotide binding protein (G protein), gamma 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG8 Gene

No ASD Table

Relevant External Links for GNG8 Gene

GeneLoc Exon Structure for
GNG8
ECgene alternative splicing isoforms for
GNG8

Expression for GNG8 Gene

mRNA expression in normal human tissues for GNG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG8 Gene

This gene is overexpressed in Brain - Hypothalamus (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNG8 Gene

SOURCE GeneReport for Unigene cluster for GNG8 Gene Hs.283961

genes like me logo Genes that share expressions with GNG8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG8 Gene

Orthologs for GNG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG8 35
  • 91.43 (n)
  • 100 (a)
GNG8 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng8 35
  • 88.1 (n)
  • 98.57 (a)
Gng8 16
Gng8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG8 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng8 35
  • 87.62 (n)
  • 98.57 (a)
lizard
(Anolis carolinensis)
Reptilia GNG8 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng8 35
  • 65.71 (n)
  • 65.71 (a)
zebrafish
(Danio rerio)
Actinopterygii gng8 35
  • 70.95 (n)
  • 80 (a)
gng8 36
  • 80 (a)
OneToOne
Species with no ortholog for GNG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG8 Gene

ENSEMBL:
Gene Tree for GNG8 (if available)
TreeFam:
Gene Tree for GNG8 (if available)

Paralogs for GNG8 Gene

Paralogs for GNG8 Gene

Selected SIMAP similar genes for GNG8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG8: view

Variants for GNG8 Gene

Sequence variations from dbSNP and Humsavar for GNG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs968394 -- 46,634,785(+) GCCCC(A/G)GTAAC upstream-variant-2KB
rs1005774 -- 46,633,905(-) TAGGG(G/T)TGGAC downstream-variant-500B
rs1566172 -- 46,633,679(+) AGGGG(C/T)TCAGG downstream-variant-500B
rs1874722 -- 46,634,545(+) AGCCC(C/G)GGACA intron-variant
rs2173284 -- 46,633,589(+) GAGTC(A/G)TTAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GNG8 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294

Relevant External Links for GNG8 Gene

HapMap Linkage Disequilibrium report
GNG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG8 Gene

Disorders for GNG8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GNG8 Gene including...

Search for GNG8 Gene in MalaCards »

Relevant External Links for GNG8

Genetic Association Database (GAD)
GNG8
Human Genome Epidemiology (HuGE) Navigator
GNG8
genes like me logo Genes that share disorders with GNG8: view

No data available for UniProtKB/Swiss-Prot for GNG8 Gene

Publications for GNG8 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. The GI^3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. (PMID: 22940628) Sun Z. … Chen S. (Cell. Signal. 2012) 3
  5. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. (PMID: 23773523) El-Haibi C.P. … Lillard J.W. (Mol. Cancer 2013) 3

Products for GNG8 Gene

Sources for GNG8 Gene

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