Aliases for GNG8 Gene
External Ids for GNG8 Gene
Previous GeneCards Identifiers for GNG8 Gene
GeneCards Summary for GNG8 Gene
GNG8 (G Protein Subunit Gamma 8) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chemokine Signaling. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG12.
UniProtKB/Swiss-Prot for GNG8 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.