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GNG7 Gene

protein-coding   GIFtS: 60
GCID: GC19M002511

Guanine Nucleotide Binding Protein (G Protein), Gamma 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 71 2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-72
GNGT73

External Ids:    HGNC: 44101   Entrez Gene: 27882   Ensembl: ENSG000001765337   OMIM: 6044305   UniProtKB: O602623   

Export aliases for GNG7 gene to outside databases

Previous GC identifers: GC19M002577 GC19M002454 GC19M002463 GC19M002464 GC19M002465 GC19M002283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNG7 Gene:
GNG7 (guanine nucleotide binding protein (G protein), gamma 7) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG7_HUMAN, O60262
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase
signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein
heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum
(By similarity)

summary for GNG7 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG7 gene promoter:
         RFX1   USF1   POU2F1   USF-1   POU2F1a   USF2   USF-1:USF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNG7 promoter sequence
   Search Chromatin IP Primers for GNG7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GNG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002511:  view genomic region     (about GC identifiers)

Start:
2,511,217 bp from pter      End:
2,702,707 bp from pter
Size:
191,491 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBG7_HUMAN, O60262 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor  
Size: 68 amino acids; 7522 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Secondary accessions: B2R496

Explore the universe of human proteins at neXtProt for GNG7: NX_O60262

Explore proteomics data for GNG7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNG7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443079.1  
    ENSEMBL proteins: 
     ENSP00000371594   ENSP00000468650  
    Reactome Protein details: O60262

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry O60262

    ProtoNet protein and cluster: O60262

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG7_HUMAN, O60262
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG7_HUMAN, O60262
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase
    signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein
    heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
         
    Find genes that share ontologies with GNG7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GNG7:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gng7):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     no phenotypic analysis 

    Find genes that share phenotypes with GNG7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gng7tm1Lex for GNG7

       genOway: Develop your customized and physiologically relevant rodent model for GNG7

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    hsa-miR-141 hsa-miR-135b hsa-miR-4254 hsa-miR-615-5p hsa-miR-3116 hsa-miR-200a hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidGNG7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBG7_HUMAN, O60262: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GNG7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNG7 About   (see all 56)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    G-protein activation0.74
    G beta-gamma signalling through PI3Kgamma0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Signal amplification0.79
    Activation of Kainate Receptors upon glutamate binding0.68
    ADP signalling through P2Y purinoceptor 10.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3fMLP Pathway
    fMLP Pathway0.43
    Alpha-Adrenergic Signaling0.38
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    4EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    5Ca-dependent events
    Opioid Signalling0.54
    Signal transduction Calcium signaling0.35


    Find genes that share SuperPaths with GNG7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG7 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG7 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG7
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    Selected Reactome Pathways for GNG7 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    1 PharmGKB Pathway for GNG7
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNG7) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNG7
    Interactions:

        Search GeneGlobe Interaction Network for GNG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG7 (O602622, 3 ENSP000003715944) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACP6Q9NPH02, 3, ENSP000003582414MINT-65570 I2D: score=5 STRING: ENSP00000358241
    MPP3Q133682, 3MINT-64781 I2D: score=5 
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB3P165203, ENSP000002292644I2D: score=2 STRING: ENSP00000229264
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0007168receptor guanylyl cyclase signaling pathway IEA--
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--

    Find genes that share ontologies with GNG7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNG7 gene: 
    NM_052847.2  

    Unigene Cluster for GNG7:

    Guanine nucleotide binding protein (G protein), gamma 7
    Hs.515544  [show with all ESTs]
    Unigene Representative Sequence: AK024465
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382159(uc002lwd.2) ENST00000587867
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    Additional mRNA sequence: 

    AB010414.1 AK024465.1 AK123863.1 AK311750.1 BC010463.1 BC014466.1 BC037318.1 BC053630.1 

    4 DOTS entries:

    DT.446523  DT.121409284  DT.87010675  DT.99941089 

    Selected AceView cDNA sequences (see all 95):

    BC010463 BU738680 T16705 BM676827 BM720289 BI547909 BM701615 AF493874 
    AL039869 BM126333 CK818935 AL039870 BU739827 BX093917 AW275324 H46880 
    AI122705 AK123863 AW204873 AI373893 CB565925 AI416975 CD172310 AI476277 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTTTTG
    GNG7 Expression
    About this image


    GNG7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    GNG7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515544

    UniProtKB/Swiss-Prot: GBG7_HUMAN, O60262
    Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GNG7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng71 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 83.33(n)1
    94.12(a)1
      10 (39.72 cM)5
    147081  NM_001038655.11  NP_001033744.11 
     809486245 
    chicken
    (Gallus gallus)
    Aves LOC1008589761 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit more 82.84(n)
    91.18(a)
      100858976  XM_003643416.2  XP_003643464.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gng71 guanine nucleotide binding protein (G protein), gamma more 76.96(n)
    88.24(a)
      549887  NM_001017133.2  NP_001017133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gng71 guanine nucleotide binding protein (G protein), gamma more 78.92(n)
    94.12(a)
      436670  NM_001002397.1  NP_001002397.1 


    ENSEMBL Gene Tree for GNG7 (if available)
    TreeFam Gene Tree for GNG7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNG7 gene
    GNG22  GNG102  GNG32  GNG82  GNG5P22  GNG52  GNG42  GNG122  
    10 SIMAP similar genes for GNG7 using alignment to 2 protein entries:     GBG7_HUMAN (see all proteins):
    GNG12    GNG8    GNG2    GNG4    GNG3    GNG5
    GNG10    GNG11    GNGT1    GNGT2

    Find genes that share paralogs with GNG7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNG7 (see all 5272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713371461,2
    C--2312363(+) TTGATCTC/-CTGGC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs58267701,2
    C--2446640(+) aaaaa-/AA/AAA
            
    tacaa
    2 -- int1 cds11NA 2
    rs1927577691,2
    --2510957(+) GCCACC/TGCGCC 1 -- int10--------
    rs349659921,2
    C--2510963(+) GCGCCC/TGGCCC 1 -- int12Minor allele frequency- T:0.05NA 122
    rs1488107101,2
    --2510967(+) CCGGCA/CCCTCC 1 -- int10--------
    rs1434571101,2
    --2510968(+) CGGCCC/TCTCCT 1 -- int10--------
    rs735144011,2
    C--2510999(+) CGAAAG/TCCCAC 1 -- int13Minor allele frequency- T:0.14WA NA 240
    rs1483677021,2
    --2511091(+) GTGGAC/TGGGAT 1 -- int10--------
    rs1432985961,2
    --2511151(+) CTTGCA/CTGCTA 1 -- int10--------
    rs1475431331,2
    C--2511180(+) AGGCCC/TGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNG7 (2511217 - 2702707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNG7 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717902CNV Deletion23290073
    esv2717900CNV Deletion23290073
    esv1706865CNV Deletion17803354
    esv2657598CNV Deletion23128226
    esv2153598CNV Deletion18987734
    esv2444878CNV Deletion19546169
    esv2717901CNV Deletion23290073
    esv2717904CNV Deletion23290073
    esv2717903CNV Deletion23290073
    esv2717899CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG7
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604430    OMIM disorders: --


    Find genes that share disorders with GNG7           About GenesLikeMe

    Genetic Association Database (GAD): GNG7
    Human Genome Epidemiology (HuGE) Navigator: GNG7 (1 document)

    Export disorders for GNG7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNG7 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with GNG7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PubMed id 9600093)1, 2, 3 Shibata K.... Akiyoshi T. (Biochem. Biophys. Res. Commun. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (PubMed id 18219292)1, 2 Ohta M.... Mori M. (Br. J. Cancer 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Identification of guanine nucleotide-binding protein I^-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. (PubMed id 23403885)1 Demokan S....Califano J.A. (Int. J. Oncol. 2013)
    8. Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck. (PubMed id 22183866)1 Hartmann S....Giefing M. (J. Appl. Genet. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2788 HGNC: 4410 AceView: GNG7 Ensembl:ENSG00000176533 euGenes: HUgn2788
    ECgene: GNG7 Kegg: 2788 H-InvDB: GNG7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNG7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNG7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNG7 gene:
    Search GeneIP for patents involving GNG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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