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GNG5 Gene

protein-coding   GIFtS: 61
GCID: GC01M084964

Guanine Nucleotide Binding Protein (G Protein), Gamma 5

  Search for GNG5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 51 2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-52
GNGT53

External Ids:    HGNC: 44081   Entrez Gene: 27872   Ensembl: ENSG000001740217   OMIM: 6008745   UniProtKB: P632183   
ORGUL members:         

Export aliases for GNG5 gene to outside databases

Previous GC identifers: GC01P085584 GC01M084102 GC01M084252 GC01M084386 GC01M084676 GC01M083074


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNG5 Gene:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from
cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its
activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex
dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate
effector molecules (Gilman, 1987 (PubMed 3113327); summary by Ahmad et al., 1995) (PubMed 7606925).(supplied by
OMIM, Nov 2010)

GeneCards Summary for GNG5 Gene:
GNG5 (guanine nucleotide binding protein (G protein), gamma 5) is a protein-coding gene. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG5 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG5 gene promoter:
         Nkx3-1   Nkx3-1 v4   FOXD1   Nkx3-1 v1   HNF-1A   Evi-1   Nkx3-1 v2   AREB6   HNF-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNG5 promoter sequence
   Search Chromatin IP Primers for GNG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22

GNG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M084964:  view genomic region     (about GC identifiers)

Start:
84,964,006 bp from pter      End:
84,972,262 bp from pter
Size:
8,257 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor  
Size: 68 amino acids; 7318 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Secondary accessions: B2R5A0 P30670 Q5VX54 Q61015

Explore the universe of human proteins at neXtProt for GNG5: NX_P63218

Explore proteomics data for GNG5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys12, Lys36
  • Modification sites at PhosphoSitePlus

  • See GNG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005265.1  
    ENSEMBL proteins: 
     ENSP00000359679   ENSP00000359675  
    Reactome Protein details: P63218

    GNG5 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNG5 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P63218

    ProtoNet protein and cluster: P63218

    UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG5_HUMAN, P63218
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNG5:
    guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites
    resulting from two separate,closely linked 5' promoters

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10819326
    GO:0004871signal transducer activity NAS--
    GO:0030165PDZ domain binding IDA--
         
    Find genes that share ontologies with GNG5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GNG5:
     Cell division defect  Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNG5
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    miRNA
    Products:
        
    miRTarBase miRNAs that target GNG5:
    hsa-mir-1 (MIRT023505), hsa-let-7e-5p (MIRT051558), hsa-mir-100-5p (MIRT048451), hsa-mir-30a-5p (MIRT028436), hsa-mir-98-5p (MIRT027504)

    Block miRNA regulation of human, mouse, rat GNG5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG5 (see all 12):
    hsa-miR-98 hsa-let-7d hsa-miR-183 hsa-let-7c hsa-miR-3647-3p hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidGNG5 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBG5_HUMAN, P63218: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    extracellular2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex NAS9790912
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GNG5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNG5 About   (see all 56)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    G-protein activation0.74
    G beta-gamma signalling through PI3Kgamma0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Signal amplification0.79
    Activation of Kainate Receptors upon glutamate binding0.68
    ADP signalling through P2Y purinoceptor 10.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3fMLP Pathway
    fMLP Pathway0.43
    Alpha-Adrenergic Signaling0.38
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    4EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    5Ca-dependent events
    Opioid Signalling0.54
    Signal transduction Calcium signaling0.35


    Find genes that share SuperPaths with GNG5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG5 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG5 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG5
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    Selected Reactome Pathways for GNG5 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    1 PharmGKB Pathway for GNG5
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNG5) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNG5
    Interactions:

        Search GeneGlobe Interaction Network for GNG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG5 (P632183 ENSP000003596754) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    GNB2P628793, ENSP000003052604I2D: score=2 STRING: ENSP00000305260
    GNB3P165203, ENSP000002292644I2D: score=2 STRING: ENSP00000229264
    GNB5O147753, ENSP000002618374I2D: score=2 STRING: ENSP00000261837
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process NAS10819326
    GO:0007165signal transduction NAS9790912
    GO:0007186G-protein coupled receptor signaling pathway NAS--
    GO:0007268synaptic transmission TAS--

    Find genes that share ontologies with GNG5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNG5 gene: 
    NM_005274.2  

    Unigene Cluster for GNG5:

    Guanine nucleotide binding protein (G protein), gamma 5
    Hs.645427  [show with all ESTs]
    Unigene Representative Sequence: BM926105
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487806 ENST00000370645(uc001djw.4) ENST00000370641
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    hsa-miR-98 hsa-let-7d hsa-miR-183 hsa-let-7c hsa-miR-3647-3p hsa-let-7i hsa-let-7e hsa-let-7g
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      QuantiFast Probe-based Assays in human, mouse, rat GNG5

    Additional mRNA sequence: 

    AF038955.1 AF493873.1 AK312111.1 BC003563.1 BT006823.1 

    15 DOTS entries:

    DT.95297551  DT.449808  DT.40133257  DT.95297552  DT.121427627  DT.121427652  DT.91807747  DT.99999113 
    DT.100823313  DT.121427685  DT.100823306  DT.121427635  DT.91718199  DT.91854010  DT.95297515 

    Selected AceView cDNA sequences (see all 423):

    CB133494 AJ709868 BQ232618 BM809260 AI479823 AI360028 CR590327 BM560945 
    N32130 AF493873 F36740 BM909433 CB133602 CB121330 AI499049 AI911433 
    CB565926 W63742 CB133657 CB121827 AI626058 BT006823 AI601142 BF109470 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTCTATT
    GNG5 Expression
    About this image


    GNG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Lung (Respiratory System)
    GNG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645427
        Custom PCR Arrays for GNG5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GNG5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng51 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 93.14(n)1
    100(a)1
      3 (71.54 cM)5
    147071  NM_010318.21  NP_034448.21 
     1464998345 
    chicken
    (Gallus gallus)
    Aves GNG51 guanine nucleotide binding protein (G protein), gamma more 80.88(n)
    92.65(a)
      424538  XM_422375.4  XP_422375.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Guanine nucleotide-binding protein subunit gamma
    90(a)
    1 → many
    GL343194.1(9617960-9621891)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI442071.12   -- 81.82(n)    BI442071.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iktdsubc_2c122 Danio rerio clone RK133A4G08 guanine nucleotide binding more 74.53(n)    AY398353.1 


    ENSEMBL Gene Tree for GNG5 (if available)
    TreeFam Gene Tree for GNG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNG5 gene
    GNG22  GNG72  GNG102  GNG32  GNG82  GNG5P22  GNG42  GNG122  
    9 SIMAP similar genes for GNG5 using alignment to 1 protein entry:     GBG5_HUMAN:
    GNG10    GNG7    GNG12    GNG2    GNG8    GNG4
    GNG3    GNGT2    GNG11

    Find genes that share paralogs with GNG5           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for GNG5
    PGOHUM00000242891 PGOHUM00000248587 PGOHUM00000243454 PGOHUM00000249704 PGOHUM00000262576


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNG5 (see all 105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136843221,2
    C--84964616(+) AGACAC/TAGAGA 1 -- int10--------
    rs1878614521,2
    --84964678(+) AACAGC/GCTAAA 1 -- int10--------
    rs1920195011,2
    C--84964732(+) GATGGA/GATACA 1 -- int10--------
    rs1504386641,2
    --84965022(+) AGACTA/GAGGTT 1 -- int10--------
    rs1465825421,2
    --84965296(+) AAGAGG/TATTTA 1 -- int10--------
    rs1845115181,2
    --84965358(+) AATAAG/TCCTGT 1 -- int10--------
    rs121405551,2
    C,F--84965364(+) CCTGTC/TGTCTT 1 -- int16Minor allele frequency- T:0.20WA NA EA 364
    rs75557731,2
    C,F,A--84965424(+) CCTGTG/ATTATT 1 -- int16Minor allele frequency- A:0.17WA CSA NA EA 364
    rs1873952631,2
    --84965447(+) GTGTAA/GAAGAG 1 -- int10--------
    rs1411913641,2
    --84965483(+) AAAAAA/GAATAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNG5 (84964006 - 84972262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GNG5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830437CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG5
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600874    OMIM disorders: --


    Find genes that share disorders with GNG5           About GenesLikeMe

    Genetic Association Database (GAD): GNG5
    Human Genome Epidemiology (HuGE) Navigator: GNG5 (1 document)

    Export disorders for GNG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNG5 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with GNG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Structure of human G protein Ggamma5 gene GNG5. (PubMed id 9790912)1, 2 Liu B. and Aronson N.N. Jr. (Biochem. Biophys. Res. Commun. 1998)
    6. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PubMed id 7606925)1, 3 Ahmad W....Aronson N.N. (Cytogenet. Cell Genet. 1995)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2787 HGNC: 4408 AceView: CTBSandGNG5 Ensembl:ENSG00000174021 euGenes: HUgn2787
    ECgene: GNG5 Kegg: 2787 H-InvDB: GNG5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNG5 gene:
    Search GeneIP for patents involving GNG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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