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Aliases for GNG5 Gene

Aliases for GNG5 Gene

  • G Protein Subunit Gamma 5 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 5 2 5
  • GNGT5 4

External Ids for GNG5 Gene

Previous GeneCards Identifiers for GNG5 Gene

  • GC01P085584
  • GC01M084102
  • GC01M084252
  • GC01M084386
  • GC01M084676
  • GC01M084964
  • GC01M083074

Summaries for GNG5 Gene

Entrez Gene Summary for GNG5 Gene

  • G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GeneCards Summary for GNG5 Gene

GNG5 (G Protein Subunit Gamma 5) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTPase activity and PDZ domain binding. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG5 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG5 Gene

Genomics for GNG5 Gene

Regulatory Elements for GNG5 Gene

Promoters for GNG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNG5 Gene

Chromosome:
1
Start:
84,498,323 bp from pter
End:
84,506,579 bp from pter
Size:
8,257 bases
Orientation:
Minus strand

Genomic View for GNG5 Gene

Genes around GNG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG5 Gene

Proteins for GNG5 Gene

  • Protein details for GNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63218-GBG5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Protein Accession:
    P63218
    Secondary Accessions:
    • B2R5A0
    • P30670
    • Q5VX54
    • Q61015

    Protein attributes for GNG5 Gene

    Size:
    68 amino acids
    Molecular mass:
    7318 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG5 Gene

Proteomics data for GNG5 Gene at MOPED

Post-translational modifications for GNG5 Gene

  • Ubiquitination at Lys 11, Lys 12, and Lys 36
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GNG5 Gene

Domains & Families for GNG5 Gene

Protein Domains for GNG5 Gene

Suggested Antigen Peptide Sequences for GNG5 Gene

Graphical View of Domain Structure for InterPro Entry

P63218

UniProtKB/Swiss-Prot:

GBG5_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG5: view

No data available for Gene Families for GNG5 Gene

Function for GNG5 Gene

Molecular function for GNG5 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites resulting from two separate,closely linked 5 promoters
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
genes like me logo Genes that share phenotypes with GNG5: view

Animal Models for GNG5 Gene

MGI Knock Outs for GNG5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG5 Gene

Localization for GNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG5 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG5 Gene COMPARTMENTS Subcellular localization image for GNG5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GNG5: view

Pathways & Interactions for GNG5 Gene

SuperPathways for GNG5 Gene

genes like me logo Genes that share pathways with GNG5: view

Gene Ontology (GO) - Biological Process for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 20277477
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG5: view

No data available for SIGNOR curated interactions for GNG5 Gene

Drugs & Compounds for GNG5 Gene

(3) Drugs for GNG5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG5 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG5: view

Transcripts for GNG5 Gene

mRNA/cDNA for GNG5 Gene

Unigene Clusters for GNG5 Gene

Guanine nucleotide binding protein (G protein), gamma 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG5 Gene

No ASD Table

Relevant External Links for GNG5 Gene

GeneLoc Exon Structure for
GNG5
ECgene alternative splicing isoforms for
GNG5

Expression for GNG5 Gene

mRNA expression in normal human tissues for GNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG5 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for GNG5 Gene

This gene is overexpressed in Nasal epithelium (40.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG5 Gene



SOURCE GeneReport for Unigene cluster for GNG5 Gene Hs.645427

genes like me logo Genes that share expression patterns with GNG5: view

Protein tissue co-expression partners for GNG5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG5 Gene

Orthologs for GNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG5 35
  • 94.61 (n)
  • 100 (a)
GNG5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG5 35
  • 92.16 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gng5 35
  • 93.14 (n)
  • 100 (a)
Gng5 16
Gng5 36
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia GNG5 35
  • 100 (n)
  • 100 (a)
GNG5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng5 35
  • 93.63 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
chicken
(Gallus gallus)
Aves GNG5 35
  • 80.88 (n)
  • 92.65 (a)
-- 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gng5 35
  • 80.39 (n)
  • 91.18 (a)
zebrafish
(Danio rerio)
Actinopterygii gng5 35
  • 72.55 (n)
  • 83.82 (a)
iktdsubc_2c12 35
gng5 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13816 35
Species with no ortholog for GNG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG5 Gene

ENSEMBL:
Gene Tree for GNG5 (if available)
TreeFam:
Gene Tree for GNG5 (if available)

Paralogs for GNG5 Gene

Paralogs for GNG5 Gene

(9) SIMAP similar genes for GNG5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG5: view

Variants for GNG5 Gene

Sequence variations from dbSNP and Humsavar for GNG5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2063038 -- 84,501,506(+) CTTGG(G/T)GACTC intron-variant
rs7545970 -- 84,500,262(+) aagca(A/G)TGCTT intron-variant
rs7555773 -- 84,499,741(+) CCTGT(A/G)TTATT intron-variant
rs17365681 -- 84,501,081(+) ACACA(C/T)GACAT intron-variant
rs17365723 -- 84,503,336(+) CTCTC(C/T)ATACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG5 Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV Gain+Loss 17160897

Variation tolerance for GNG5 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG5 Gene

HapMap Linkage Disequilibrium report
GNG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG5 Gene

Disorders for GNG5 Gene

Relevant External Links for GNG5

Genetic Association Database (GAD)
GNG5
Human Genome Epidemiology (HuGE) Navigator
GNG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG5

No disorders were found for GNG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG5 Gene

Publications for GNG5 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PMID: 7606925) Ahmad W. … Aronson N.N. (Cytogenet. Cell Genet. 1995) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GNG5 Gene

Sources for GNG5 Gene

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