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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNG5 Gene

protein-coding GIFtS: 57
GCID: GC01M084964

guanine nucleotide binding protein (G protein), gamma 5

Explore 3 diseases affiliated with
GNG5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 5¹ ²
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-5²
GNGT5³

External Ids:	HGNC: 4408¹	Entrez Gene: 2787²	Ensembl: ENSG00000174021⁷	OMIM: 600874⁵	UniProtKB: P63218³

Export aliases for GNG5 gene to outside databases

Previous GC identifers: GC01P085584 GC01M084102 GC01M084252 GC01M084386 GC01M084676 GC01M083074

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNG5:

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell

surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor

promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the

beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987

(PubMed 3113327); summary by Ahmad et al., 1995) (PubMed 7606925).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

summary for GNG5:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; in addition, some

Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and

Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNG5 gene promoter:
Nkx3-1 Nkx3-1 v4 FOXD1 Nkx3-1 v1 HNF-1A Evi-1 Nkx3-1 v2 AREB6 HNF-1 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNG5 promoter sequence

Search SABiosciences Chromatin IP Primers for GNG5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22

GNG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M084964: view genomic region (about GC identifiers)

Start:	84,964,006 bp from pter	End:	84,972,262 bp from pter
Size:	8,257 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor

Size: 68 amino acids; 7318 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Secondary accessions: B2R5A0 P30670 Q5VX54 Q61015

Explore the universe of human proteins at neXtProt for GNG5: NX_P63218

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P63218

GNG5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005265.1

ENSEMBL proteins:

ENSP00000359679 ENSP00000359675

Reactome Protein details: P63218
Human Recombinant Protein Products:

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	Novus Biologicals GNG5 Proteins Novus Biologicals GNG5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005834	heterotrimeric G-protein complex	NAS	9790912
GO:0005886	plasma membrane	TAS	--

GNG5 for ontologies About GeneDecksing

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Assay Products for GNG5:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNG5 for domains About GeneDecksing

2 InterPro domains/families:

IPR001770 Gprotein-gamma

IPR015898 G-protein_gamma-like_dom

Graphical View of Domain Structure for InterPro Entry P63218

ProtoNet protein and cluster: P63218

UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218

Similarity: Belongs to the G protein gamma family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GBG5_HUMAN, P63218

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

Genatlas biochemistry entry for GNG5:

guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites

resulting from two separate,closely linked 5' promoters

miRNA Products:		OriGene 3'-UTR Clone: GNG5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG5
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG5 (see all 12):
		hsa-miR-98 hsa-let-7d hsa-miR-183 hsa-let-7c hsa-miR-3647-3p hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: GNG5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	NAS	10819326
GO:0004871	signal transducer activity	NAS	--

GNG5 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for GNG5:

Cell division defect

Increased S DNA content

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/60 super-pathways (see all 60) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

8/12 pathways (see all 12)
G beta:gamma signalling through PLC beta	1.00	G beta:gamma signalling through PI3Kgamma	0.61
Presynaptic function of Kainate receptors	0.95	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.55
Prostacyclin signalling through prostacyclin receptor	0.77	G-protein activation	0.55
G-protein beta:gamma signalling	0.71	Glucagon-type ligand receptors	0.52

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/31 EMD Millipore Pathways for GNG5 (see all 31)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling

5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG5 (see all 47)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

5/34 GeneGo (Thomson Reuters) Pathways for GNG5 (see all 34)

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

3 BioSystems Pathways for GNG5

	Myometrial Relaxation and Contraction Pathways
	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell

5/48 Reactome Pathways for GNG5 (see all 48)

	G alpha (12/13) signalling events
	Platelet homeostasis
	G protein gated Potassium channels
	G alpha (z) signalling events
	Inwardly rectifying K+ channels

1 PharmGKB Pathway for GNG5

Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for GNG5):

	Chemokine signaling pathway
	Glutamatergic synapse
	Cholinergic synapse

GNG5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNG5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for GNG5 (P63218³ ENSP00000359675⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
GNB4	Q9HAV0³, ENSP00000232564⁴	I2D: score=2 STRING: ENSP00000232564
GNB2	P62879³, ENSP00000305260⁴	I2D: score=2 STRING: ENSP00000305260
GNB3	P16520³, ENSP00000229264⁴	I2D: score=2 STRING: ENSP00000229264
GNB5	O14775³, ENSP00000261837⁴	I2D: score=2 STRING: ENSP00000261837

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006184	GTP catabolic process	NAS	10819326
GO:0007165	signal transduction	NAS	9790912
GO:0007186	G-protein coupled receptor signaling pathway	NAS	--
GO:0007268	synaptic transmission	TAS	--

GNG5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNG5 available from Tocris Bioscience About this table

Compound	Action	CAS #
Gallein	Inhibitor of betagamma signaling	[2103-64-2]
GRK2i	GRK2 inhibitory polypeptide. Gbetagamma antagonist	[148505-03-7]

3 HMDB Compounds for GNG5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNG5 / GBG5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNG5 gene:

NM_005274.2

Unigene Cluster for GNG5:

Guanine nucleotide binding protein (G protein), gamma 5

Hs.645427 [show with all ESTs]

Unigene Representative Sequence: BM926105

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487806 ENST00000370645(uc001djw.4) ENST00000370641

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		hsa-miR-98 hsa-let-7d hsa-miR-183 hsa-let-7c hsa-miR-3647-3p hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: GNG5 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG5

Additional cDNA sequence:

AF038955.1 AF493873.1 AK312111.1 BC003563.1 BT006823.1

17 DOTS entries:

DT.95297551 DT.449808 DT.40133257 DT.95297552 DT.121427627 DT.95297515 DT.121427652 DT.91807747

DT.99999113 DT.100823313 DT.121427685 DT.91854010 DT.100823306 DT.121427635 DT.86841873 DT.91718199

DT.92443364

24/423 AceView cDNA sequences (see all 423):

AI346848 BM909433 N32130 BE883964 BM809260 NM_004388 AF493873 CD675340

CB133718 CB565926 CB133494 BF446333 CB133602 AA182869 AI339601 W63742

AI479823 BU190432 BF724633 AI368858 CB241216 H15938 CD108724 CR590327

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTCTATT

About this image

GNG5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNG5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNG5

SOURCE GeneReport for Unigene cluster: Hs.645427

SABiosciences Custom PCR Arrays for GNG5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GNG5 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNG5¹	guanine nucleotide binding protein (G protein), gamma more	80.88(n) 92.65(a)		424538 XM_422375.3 XP_422375.3
lizard (Anolis carolinensis)	Reptilia	--	--	90(a)	1 → many	GL343194.1(9617960-9621891)
African clawed frog (Xenopus laevis)	Amphibia	BI442071.1²	--	81.82(n)		BI442071.1
zebrafish (Danio rerio)	Actinopterygii	iktdsubc_2c12²	Danio rerio clone RK133A4G08 guanine nucleotide binding more	74.53(n)		AY398353.1

ENSEMBL Gene Tree for GNG5 (if available)
TreeFam Gene Tree for GNG5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNG5 gene

GNG2² GNG7² GNG10² GNG3² GNG8² GNG5P2² GNG4² GNG12²

10 SIMAP similar genes for GNG5 using alignment to 1 protein entry: GBG5_HUMAN:

GNG10 GNG7 DKFZp762E193 GNG12 GNG2 GNG8

GNG4 GNG3 GNGT2 GNG11

GNG5 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for GNG5
PGOHUM00000242891 PGOHUM00000248587 PGOHUM00000243454 PGOHUM00000249704 PGOHUM00000262576

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7524195^1,2	C,F,	--	83080303(+)	`GGTAGG/AATCAG`	1	--	us2k¹		1		WA	118
rs59742045^1,2	C,F,	--	83080960(+)	`AACAGG/AGCACA`	1	--	us2k¹		3		WA CSA	122
rs2174654^1,2		--	83081249(-)	`CTCGTA/GTTTGA`	1	--	us2k¹		0	--	--	--	--
rs11163985^1,2		--	83082043(-)	`GGCCCC/GGCCGA`	1	--	us2k¹ ese³		3		NA CSA WA	121
rs41284589^1,2	F,	--	83082136(+)	`TCGGTG/ACGCAT`	1	--	ut5¹		1		NA	120
rs13093^1,2	C,	--	83082179(-)	`GGGGCC/AGGGTG`	1	--	ut5¹ ese³		8		MN CSA WA NA EA	730
rs6701280^1,2	C,F,A,H,	--	83082269(+)	`CGACTC/GTTAAG`	1	--	ut5¹		11		NS EA NA WA CSA	777
rs12092954^1,2	F,	--	83082299(+)	`GGGGCC/GGATTA`	1	--	ut5¹ ese³		1		NA	120
rs6676502^1,2	C,F,A,	--	83082487(+)	`ACTGGG/CTGAGG`	1	--	int¹		9		MN EA NA WA CSA	1499
rs12093101^1,2	F,H,	--	83082546(+)	`CCGTAC/TAGGCG`	1	--	int¹		5		NS EA NA	534

HapMap Linkage Disequilibrium report for GNG5 (84964006 - 84972262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for GNG5
3 CNVs: 84346 84347 84345
9 Indels: 74558 74557 74555 74554 74559 84349 84348 74556 74553

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GNG5 for disorders           About GeneDecksing

OMIM gene information: 600874    OMIM disorders: --

3 diseases for GNG5:    About MalaCards

huntington's disease colorectal cancer breast cancer

Human Genome Epidemiology (HuGE) Navigator: GNG5 (1 document)

Export disorders for GNG5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GNG5 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with GNG5)

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world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Structure of human G protein Ggamma5 gene GNG5. (PubMed id 9790912)^{1, 2} Liu B. and Aronson N.N. Jr. (1998)
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)^{1, 2} Mao M.... Chen Z. (1998)
Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PubMed id 7606925)^{1, 3} Ahmad W....Aronson N.N. (1995)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2787	HGNC: 4408	AceView: CTBSandGNG5	Ensembl:ENSG00000174021	euGenes: HUgn2787
ECgene: GNG5	Kegg: 2787	H-InvDB: GNG5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNG5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNG5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GNG5 gene:
Search GeneIP for patents involving GNG5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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guanine nucleotide binding protein (G protein), gamma 5

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guanine nucleotide binding protein (G protein), gamma 5

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