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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNG4 Gene

protein-coding   GIFtS: 58
GCID: GC01M235710

Guanine Nucleotide Binding Protein (G Protein), Gamma 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 41 2
Guanine Nucleotide Binding Protein 42
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-42
GNGT43

External Ids:    HGNC: 44071   Entrez Gene: 27862   Ensembl: ENSG000001682437   OMIM: 6043885   UniProtKB: P501503   

Export aliases for GNG4 gene to outside databases

Previous GC identifers: GC01M233846 GC01M231167 GC01M232010 GC01M232755 GC01M232040 GC01M206162


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GNG4 Gene: 
GNG4 (guanine nucleotide binding protein (G protein), gamma 4) is a protein-coding gene. Diseases associated with GNG4 include fainting, and huntington's disease, and among its related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG4 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNG4 gene promoter:
         IRF-2   AML1a   FOXF2   HNF-3beta   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.3   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.3

GNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235710:  view genomic region     (about GC identifiers)

Start:
235,710,985 bp from pter      End:
235,814,054 bp from pter
Size:
103,070 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor  
Size: 75 amino acids; 8389 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with
beta-3
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Explore the universe of human proteins at neXtProt for GNG4: NX_P50150

Explore proteomics data for GNG4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50150

  • GNG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNG4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001092191.1  NP_001092192.1  NP_004476.1  

    ENSEMBL proteins: 
     ENSP00000355556   ENSP00000355557   ENSP00000398629   ENSP00000375727  
    Reactome Protein details: P50150
    Human Recombinant Protein Products for GNG4: 
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    Novus Biologicals GNG4 Protein
    Novus Biologicals GNG4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    GNG4 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P50150

    ProtoNet protein and cluster: P50150

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
    Similarity: Belongs to the G protein gamma family


    GNG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG4_HUMAN, P50150
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
         
    GNG4 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNG4 About   (see all 62)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PI3Kgamma0.89
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.61
    Prostacyclin signalling through prostacyclin receptor0.77
    Glucagon-type ligand receptors0.58
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    3Thromboxane signalling through TP receptor
    Signal amplification0.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    ADP signalling through P2Y purinoceptor 10.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    5Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNG4 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/70 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG4 (see all 70)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNG4 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG4
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    5/48        Reactome Pathways for GNG4 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    1 PharmGKB Pathway for GNG4
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for GNG4) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNG4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for GNG4 (P501501, 3 ENSP000003555564) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    GNB2P628793, ENSP000003052604I2D: score=3 STRING: ENSP00000305260
    GNB3P165203, ENSP000002292644I2D: score=2 STRING: ENSP00000229264
    GNB5O147753, ENSP000002618374I2D: score=2 STRING: ENSP00000261837
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS7665596
    GO:0030308negative regulation of cell growth IMP15824735

    GNG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNG4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNG4 / GBG4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNG4 gene (3 alternative transcripts): 
    NM_001098721.1  NM_001098722.1  NM_004485.3  

    Unigene Cluster for GNG4:

    Guanine nucleotide binding protein (G protein), gamma 4
    Hs.159711  [show with all ESTs]
    Unigene Representative Sequence: NM_001098722
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366597 ENST00000366598 ENST00000484517 ENST00000450593(uc009xfz.3 uc001hxh.4)
    ENST00000391854(uc001hxe.4)
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    Additional mRNA sequence: 

    AF493872.1 AK074383.1 AK126090.1 AK311781.1 AL832564.1 BC022485.1 U31382.1 

    8 DOTS entries:

    DT.309052  DT.423639  DT.121386873  DT.100024019  DT.100679221  DT.92423701  DT.91729514  DT.97777063 

    24/150 AceView cDNA sequences (see all 150):

    BX329660 CR593666 BG151513 BQ189314 BE219515 BV179948 BU789939 AI497657 
    AW005645 CR592582 BG912863 CR607248 AI871243 AA471017 AI339945 BX452209 
    BX098891 AI954695 BQ962447 BQ010569 AI634084 BF592764 AL523588 CB154393 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GNG4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -           -                           
    SP2:                          -                           
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for GNG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNG4 expression in normal human tissues (normalized intensities)      GNG4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACAGCAG
    GNG4 Expression
    About this image


    GNG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Human Hippocampal Astrocytes   
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate

    See GNG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNG4

    SOURCE GeneReport for Unigene cluster: Hs.159711

    UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
    Tissue specificity: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle

        SABiosciences Expression via Pathway-Focused PCR Array including GNG4: 
              Alzheimer's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng41 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 89.78(n)1
    98.67(a)1
      13 (5.29 cM)5
    147061  NM_010317.21  NP_034447.11 
     137840595 
    chicken
    (Gallus gallus)
    Aves GNG41 guanine nucleotide binding protein (G protein), gamma more 76.13(n)
    85.14(a)
      771582  XM_001233857.2  XP_001233858.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG46
    Guanine nucleotide-binding protein subunit gamma
    84(a)
    1 ↔ 1
    1(219406963-219416435)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245532 Xenopus laevis transcribed sequence with moderate similarity more 74.09(n)    CB199702.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gng32 guanine nucleotide binding protein (G protein), gamma more 76.89(n)   114462  AF364083.1 


    ENSEMBL Gene Tree for GNG4 (if available)
    TreeFam Gene Tree for GNG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNG4 gene
    GNG22  GNG72  GNG102  GNG32  GNG82  GNG5P22  GNG52  GNG122  
    11 SIMAP similar genes for GNG4 using alignment to 2 protein entries:     GBG4_HUMAN (see all proteins):
    GNG2    GNG8    DKFZp762E193    GNG12    GNG7    GNG3
    GNG5    GNG10    GNGT2    GNG11    GNGT1

    GNG4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2513 SNPs in GNG4 are shown (see all 2513)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386473261,2
    --235710494(+) CCATCA/GGTATT 3 -- int10--------
    rs1916685881,2
    --235710520(+) TAATAC/TCTACG 3 -- int10--------
    rs66642191,2
    C,F,A,H--235710572(+) CATAGA/GAGAGC 3 -- int119Minor allele frequency- G:0.43NA NS EA WA CSA 1218
    rs1841820991,2
    --235710605(+) TCCCTC/TCCCAA 3 -- int10--------
    rs772809911,2
    C,F--235710611(+) CCCAAC/TGGTGG 3 -- int11Minor allele frequency- T:0.04WA 118
    rs1888529501,2
    --235710681(+) GGCAGC/GAGAGC 3 -- int10--------
    rs1492874251,2
    --235710713(+) CATCAA/TGTGGG 3 -- int10--------
    rs66763531,2
    C,F,A,H--235710776(+) ATTTGT/CGCATC 3 -- int129Minor allele frequency- C:0.43NA NS EA WA CSA 2916
    rs1808345511,2
    --235710875(+) CAAGCA/GTGCTC 3 -- int10--------
    rs1435724791,2
    --235710916(+) CATTAA/GTGTAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for GNG4 (235710985 - 235814054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNG4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2471335CNV Insertion19546169
    dgv549n71CNV Gain21882294
    dgv30n21CNV Gain19592680
    nsv832936CNV Gain17160897
    nsv873322CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604388    OMIM disorders: --

    6 diseases for GNG4:    About MalaCards
    fainting    huntington's disease    colorectal cancer    alzheimer's disease
    breast cancer    neuronitis


    GNG4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNG4

    Export disorders for GNG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNG4 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with GNG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
    2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)1, 4 Lunetta K.L....Murabito J.M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of novel VHL target genes and relationship to hypoxic response pathways. (PubMed id 15824735)1, 9 Maina E.N....Maher E.R. (2005)
    5. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (2009)
    6. Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (2009)
    7. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. (PubMed id 16884933)1 Goddard A....Davey J. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2786 HGNC: 4407 AceView: GNG4 Ensembl:ENSG00000168243 euGenes: HUgn2786
    ECgene: GNG4 Kegg: 2786 H-InvDB: GNG4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNG4 gene:
    Search GeneIP for patents involving GNG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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