Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GNG4 Gene

protein-coding   GIFtS: 56
GCID: GC01M235710

Guanine Nucleotide Binding Protein (G Protein), Gamma 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 41 2
Guanine Nucleotide Binding Protein 42
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-42
GNGT43

External Ids:    HGNC: 44071   Entrez Gene: 27862   Ensembl: ENSG000001682437   OMIM: 6043885   UniProtKB: P501503   

Export aliases for GNG4 gene to outside databases

Previous GC identifers: GC01M233846 GC01M231167 GC01M232010 GC01M232755 GC01M232040 GC01M206162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GNG4 Gene:
GNG4 (guanine nucleotide binding protein (G protein), gamma 4) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG4 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG4 gene promoter:
         IRF-2   AML1a   FOXF2   HNF-3beta   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNG4 promoter sequence
   Search Chromatin IP Primers for GNG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.3   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.3

GNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235710:  view genomic region     (about GC identifiers)

Start:
235,710,985 bp from pter      End:
235,814,054 bp from pter
Size:
103,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor  
Size: 75 amino acids; 8389 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with
beta-3

Explore the universe of human proteins at neXtProt for GNG4: NX_P50150

Explore proteomics data for GNG4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001092191.1  NP_001092192.1  NP_004476.1  

    ENSEMBL proteins: 
     ENSP00000355556   ENSP00000355557   ENSP00000398629   ENSP00000375727  
    Reactome Protein details: P50150

    GNG4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GNG4
    OriGene Protein Over-expression Lysate for GNG4
    OriGene MassSpec for GNG4
    OriGene Custom Protein Services for GNG4
    GenScript Custom Purified and Recombinant Proteins Services for GNG4
    Novus Biologicals GNG4 Protein
    Novus Biologicals GNG4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNG4 

     
    antibodies-online proteins for GNG4 (2 products) 

     
    antibodies-online peptides for GNG4

    GNG4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GNG4
    Novus Biologicals GNG4 Antibodies
    Search for Antibodies for GNG4 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GNG4
    antibodies-online antibodies for GNG4 (9 products) 

    GNG4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GNG4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNG4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNG4 
    antibodies-online kits for GNG4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P50150

    ProtoNet protein and cluster: P50150

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG4_HUMAN, P50150
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with GNG4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GNG4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GNG4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG4 (see all 12):
    hsa-miR-569 hsa-miR-203 hsa-miR-4311 hsa-miR-495 hsa-miR-3616-5p hsa-miR-589* hsa-miR-3647-5p hsa-miR-597
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNG4
    Predesigned siRNA for gene silencing in human, mouse, rat GNG4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNG4

    Clone
    Products:
         
    OriGene clones in human, mouse for GNG4 (see all 18)
    OriGene ORF clones in mouse, rat for GNG4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GNG4 (NM_001098721)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNG4
    Browse ESI BIO Cell Lines and PureStem Progenitors for GNG4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GBG4_HUMAN, P50150: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with GNG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GNG4 About   (see all 62)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58


    Find genes that share SuperPaths with GNG4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG4 (see all 70)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG4 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG4
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    Selected Reactome Pathways for GNG4 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    1 PharmGKB Pathway for GNG4
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNG4) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Array including GNG4: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GNG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG4 (P501501, 3 ENSP000003555564) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    GNB2P628793, ENSP000003052604I2D: score=3 STRING: ENSP00000305260
    GNB3P165203, ENSP000002292644I2D: score=2 STRING: ENSP00000229264
    GNB5O147753, ENSP000002618374I2D: score=2 STRING: ENSP00000261837
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS7665596
    GO:0030308negative regulation of cell growth IMP15824735

    Find genes that share ontologies with GNG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GNG4 gene (3 alternative transcripts): 
    NM_001098721.1  NM_001098722.1  NM_004485.3  

    Unigene Cluster for GNG4:

    Guanine nucleotide binding protein (G protein), gamma 4
    Hs.159711  [show with all ESTs]
    Unigene Representative Sequence: NM_001098722
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366597 ENST00000366598 ENST00000484517 ENST00000450593(uc009xfz.3 uc001hxh.4)
    ENST00000391854(uc001hxe.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GNG4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG4 (see all 12):
    hsa-miR-569 hsa-miR-203 hsa-miR-4311 hsa-miR-495 hsa-miR-3616-5p hsa-miR-589* hsa-miR-3647-5p hsa-miR-597
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GNG4
    Predesigned siRNA for gene silencing in human, mouse, rat GNG4
    Clone
    Products:
         
    OriGene clones in human, mouse for GNG4 (see all 18)
    OriGene ORF clones in mouse, rat for GNG4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GNG4 (NM_001098721)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNG4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNG4
      QuantiTect SYBR Green Assays in human, mouse, rat GNG4
      QuantiFast Probe-based Assays in human, mouse, rat GNG4

    Additional mRNA sequence: 

    AF493872.1 AK074383.1 AK126090.1 AK311781.1 AL832564.1 BC022485.1 U31382.1 

    8 DOTS entries:

    DT.309052  DT.423639  DT.121386873  DT.100024019  DT.100679221  DT.92423701  DT.91729514  DT.97777063 

    Selected AceView cDNA sequences (see all 150):

    AI497657 BG151513 BV179948 BQ189314 CR593666 BE219515 BU789939 BG912863 
    AW005645 CR607248 CR592582 BX329660 CB153077 AA298266 AI215802 BM467111 
    BF591639 AI634084 BQ015658 CB051175 BX098891 AA471017 AI916843 BE048818 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GNG4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -           -                           
    SP2:                          -                           
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for GNG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GNG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACAGCAG
    GNG4 Expression
    About this image


    GNG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Human Hippocampal Astrocytes   
             Septum   
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Epidermis (Integumentary System)
    GNG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159711

    UniProtKB/Swiss-Prot: GBG4_HUMAN, P50150
    Tissue specificity: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including GNG4: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNG4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNG4
    QuantiTect SYBR Green Assays in human, mouse, rat GNG4
    QuantiFast Probe-based Assays in human, mouse, rat GNG4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng41 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 89.78(n)1
    98.67(a)1
      13 (5.29 cM)5
    147061  NM_010317.21  NP_034447.11 
     137840595 
    chicken
    (Gallus gallus)
    Aves GNG41 guanine nucleotide binding protein (G protein), gamma more 76.13(n)
    85.14(a)
      771582  XM_004935472.1  XP_004935529.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG46
    guanine nucleotide binding protein (G protein), ga...
    84(a)
    1 ↔ 1
    1(219406963-219416435)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245532 Xenopus laevis transcribed sequence with moderate similarity more 74.09(n)    CB199702.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gng32 guanine nucleotide binding protein (G protein), gamma more 76.89(n)   114462  AF364083.1 


    ENSEMBL Gene Tree for GNG4 (if available)
    TreeFam Gene Tree for GNG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GNG4 gene
    GNG22  GNG72  GNG102  GNG32  GNG82  GNG5P22  GNG52  GNG122  
    10 SIMAP similar genes for GNG4 using alignment to 2 protein entries:     GBG4_HUMAN (see all proteins):
    GNG2    GNG8    GNG12    GNG7    GNG3    GNG5
    GNG10    GNGT2    GNG11    GNGT1

    Find genes that share paralogs with GNG4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GNG4 (see all 2513)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386473261,2
    --235710494(+) CCATCA/GGTATT 3 -- int10--------
    rs1916685881,2
    --235710520(+) TAATAC/TCTACG 3 -- int10--------
    rs66642191,2
    C,F,A,H--235710572(+) CATAGA/GAGAGC 3 -- int119Minor allele frequency- G:0.43NA NS EA WA CSA 1218
    rs1841820991,2
    --235710605(+) TCCCTC/TCCCAA 3 -- int10--------
    rs772809911,2
    C,F--235710611(+) CCCAAC/TGGTGG 3 -- int11Minor allele frequency- T:0.04WA 118
    rs1888529501,2
    --235710681(+) GGCAGC/GAGAGC 3 -- int10--------
    rs1492874251,2
    --235710713(+) CATCAA/TGTGGG 3 -- int10--------
    rs66763531,2
    C,F,A,H--235710776(+) ATTTGT/CGCATC 3 -- int129Minor allele frequency- C:0.43NA NS EA WA CSA 2916
    rs1808345511,2
    --235710875(+) CAAGCA/GTGCTC 3 -- int10--------
    rs1435724791,2
    --235710916(+) CATTAA/GTGTAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for GNG4 (235710985 - 235814054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2471335CNV Insertion19546169
    dgv549n71CNV Gain21882294
    dgv30n21CNV Gain19592680
    nsv832936CNV Gain17160897
    nsv873322CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG4
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604388    OMIM disorders: --


    Find genes that share disorders with GNG4           About GenesLikeMe

    Genetic Association Database (GAD): GNG4

    Export disorders for GNG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GNG4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with GNG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (J. Biol. Chem. 1995)
    2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)1, 4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of novel VHL target genes and relationship to hypoxic response pathways. (PubMed id 15824735)1, 9 Maina E.N....Maher E.R. (Oncogene 2005)
    5. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (Cell. Signal. 2009)
    6. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    7. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (J. Physiol. (Lond.) 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. (PubMed id 16884933)1 Goddard A....Davey J. (amp 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2786 HGNC: 4407 AceView: GNG4 Ensembl:ENSG00000168243 euGenes: HUgn2786
    ECgene: GNG4 Kegg: 2786 H-InvDB: GNG4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GNG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GNG4 gene:
    Search GeneIP for patents involving GNG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GNG4  
     OriGene qPCR primer pairs and template standards for GNG4   OriGene Protein Over-expression Lysate for GNG4  
     OriGene MassSpec for GNG4   OriGene clones in human, mouse for GNG4  
     Browse OriGene qSTAR qPCR primer pairs   OriGene Purified Protein for GNG4  
     OriGene ORF clones in mouse, rat for GNG4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNG4   OriGene Custom Protein Services for GNG4  

     
     
     Block miRNA regulation of human, mouse, rat GNG4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GNG4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG4 Predesigned siRNA for gene silencing in human, mouse, rat GNG4
     QuantiFast Probe-based Assays in human, mouse, rat GNG4 QuantiTect SYBR Green Assays in human, mouse, rat GNG4
     PCR Arrays including human, mouse, rat GNG4 Search Chromatin IP Primers for GNG4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNG4  Search GeneGlobe Interaction Network for GNG4
     Regulatory tfbs in GNG4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GNG4 GenScript cDNA clones with any tag delivered in your preferred vector for GNG4
     GenScript Custom Assay Services for GNG4 GenScript Custom overexpressing Cell Line Services for GNG4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GNG4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GNG4 antibodies
     GNG4 proteins
     GNG4 lysates
     Search for Antibodies for GNG4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GNG4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GNG4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GNG4
     SwitchGear Promoter luciferase reporter plasmids for GNG4
     Search ThermoFisher Antibodies for GNG4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG4
     Browse compounds at ApexBio
     Search Addgene for plasmids for GNG4
      Search eBioscience for proteins for GNG4
      Search eBioscience for elisas for GNG4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GNG4
     antibodies-online antibodies for GNG4 (9 products)
     antibodies-online kits for GNG4 (2 products)
     antibodies-online peptides for GNG4
     antibodies-online proteins for GNG4 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNG4 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4