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Aliases for GNG4 Gene

Aliases for GNG4 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 4 2 3
  • GNGT4 4

External Ids for GNG4 Gene

Previous GeneCards Identifiers for GNG4 Gene

  • GC01M233846
  • GC01M231167
  • GC01M232010
  • GC01M232755
  • GC01M232040
  • GC01M235710
  • GC01M206162

Summaries for GNG4 Gene

GeneCards Summary for GNG4 Gene

GNG4 (Guanine Nucleotide Binding Protein (G Protein), Gamma 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG4 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG4 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG4 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG4 Gene

Genomics for GNG4 Gene

Regulatory Elements for GNG4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG4 Gene

235,547,685 bp from pter
235,650,754 bp from pter
103,070 bases
Minus strand

Genomic View for GNG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG4 Gene

Proteins for GNG4 Gene

  • Protein details for GNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for GNG4 Gene

    75 amino acids
    Molecular mass:
    8389 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3

neXtProt entry for GNG4 Gene

Proteomics data for GNG4 Gene at MOPED

Post-translational modifications for GNG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG4 Gene

No data available for DME Specific Peptides for GNG4 Gene

Domains for GNG4 Gene

Protein Domains for GNG4 Gene

Graphical View of Domain Structure for InterPro Entry



  • P50150
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG4: view

No data available for Gene Families for GNG4 Gene

Function for GNG4 Gene

Molecular function for GNG4 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 23021213
genes like me logo Genes that share ontologies with GNG4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GNG4 Gene

Localization for GNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG4 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for GNG4 Gene COMPARTMENTS Subcellular localization image for GNG4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GNG4: view

Pathways for GNG4 Gene

SuperPathways for GNG4 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 fMLP Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with GNG4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 7665596
GO:0030308 negative regulation of cell growth IMP 15824735
genes like me logo Genes that share ontologies with GNG4: view

Compounds for GNG4 Gene

(5) Tocris Compounds for GNG4 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with GNG4: view

Transcripts for GNG4 Gene

Unigene Clusters for GNG4 Gene

Guanine nucleotide binding protein (G protein), gamma 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for GNG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNG4 Gene

mRNA expression in normal human tissues for GNG4 Gene

mRNA differential expression in normal tissues according to GTEx for GNG4 Gene

This gene is overexpressed in Brain - Hypothalamus (5.1), Brain - Amygdala (5.0), Pituitary (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Protein differential expression in normal tissues for GNG4 Gene

This gene is overexpressed in Retina (21.1), Fetal Brain (14.2), Islet of Langerhans (9.8), Pancreas (8.5), and Ovary (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG4 Gene

SOURCE GeneReport for Unigene cluster for GNG4 Gene Hs.159711

mRNA Expression by UniProt/SwissProt for GNG4 Gene

Tissue specificity: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle
genes like me logo Genes that share expressions with GNG4: view

Expression partners for GNG4 Gene

In Situ Assay Products

Orthologs for GNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GNG4 35
  • 92 (n)
  • 98.67 (a)
GNG4 36
  • 99 (a)
(Canis familiaris)
Mammalia GNG4 35
  • 91.56 (n)
  • 98.67 (a)
GNG4 36
  • 63 (a)
(Mus musculus)
Mammalia Gng4 35
  • 89.78 (n)
  • 98.67 (a)
Gng4 16
Gng4 36
  • 99 (a)
(Pan troglodytes)
Mammalia GNG4 35
  • 99.56 (n)
  • 100 (a)
GNG4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gng4 35
  • 90.67 (n)
  • 98.67 (a)
(Monodelphis domestica)
Mammalia GNG4 36
  • 95 (a)
(Gallus gallus)
Aves GNG4 35
  • 76.13 (n)
  • 85.14 (a)
GNG4 36
  • 85 (a)
(Anolis carolinensis)
Reptilia GNG4 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng4 35
  • 79.11 (n)
  • 90.67 (a)
Str.11936 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24553 35
(Danio rerio)
Actinopterygii gng3 35
Species with no ortholog for GNG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG4 Gene

Gene Tree for GNG4 (if available)
Gene Tree for GNG4 (if available)

Paralogs for GNG4 Gene

Paralogs for GNG4 Gene

Selected SIMAP similar genes for GNG4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG4: view

Variants for GNG4 Gene

Sequence variations from dbSNP and Humsavar for GNG4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14326 -- 235,552,223(-) GCAGC(C/T)GCGGA synonymous-codon, reference
rs291349 -- 235,561,455(-) cagcc(A/G)ggtgg intron-variant
rs291350 -- 235,561,410(-) ATATA(A/T)AGAGA intron-variant
rs291351 -- 235,561,275(-) tccca(A/G)cactt intron-variant
rs291352 -- 235,558,528(-) AGACT(C/T)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG4 Gene

Variant ID Type Subtype PubMed ID
dgv30n21 CNV Gain 19592680
nsv873322 CNV Gain 21882294
dgv549n71 CNV Gain 21882294
esv2471335 CNV Insertion 19546169
nsv832936 CNV Gain 17160897

Relevant External Links for GNG4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG4 Gene

Disorders for GNG4 Gene

Relevant External Links for GNG4

Genetic Association Database (GAD)

No disorders were found for GNG4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GNG4 Gene

Publications for GNG4 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 3 48
  4. Identification of novel VHL target genes and relationship to hypoxic response pathways. (PMID: 15824735) Maina E.N. … Maher E.R. (Oncogene 2005) 3 23
  5. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PMID: 19168127) Poon L.S. … Wong Y.H. (Cell. Signal. 2009) 3

Products for GNG4 Gene

Sources for GNG4 Gene

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