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Aliases for GNG3 Gene

Aliases for GNG3 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 3 2 3
  • Guanine Nucleotide-Binding Protein Gamma-3 Subunit 2
  • NBP Gamma-3 2
  • GNGT3 4

External Ids for GNG3 Gene

Summaries for GNG3 Gene

Entrez Gene Summary for GNG3 Gene

  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

GeneCards Summary for GNG3 Gene

GNG3 (Guanine Nucleotide Binding Protein (G Protein), Gamma 3) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG3 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG3 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG3 Gene

Genomics for GNG3 Gene

Genomic Location for GNG3 Gene

Start:
62,706,687 bp from pter
End:
62,709,206 bp from pter
Size:
2,520 bases
Orientation:
Plus strand

Genomic View for GNG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG3 Gene

Regulatory Elements for GNG3 Gene

Proteins for GNG3 Gene

  • Protein details for GNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63215-GBG3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Protein Accession:
    P63215
    Secondary Accessions:
    • B2R4S7
    • P29798
    • Q61014

    Protein attributes for GNG3 Gene

    Size:
    75 amino acids
    Molecular mass:
    8305 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG3 Gene

Proteomics data for GNG3 Gene at MOPED

Post-translational modifications for GNG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG3 Gene

Domains for GNG3 Gene

Protein Domains for GNG3 Gene

Suggested Antigen Peptide Sequences for GNG3 Gene

Graphical View of Domain Structure for InterPro Entry

P63215

UniProtKB/Swiss-Prot:

GBG3_HUMAN
Family:
  • Belongs to the G protein gamma family.:
    • P63215
genes like me logo Genes that share domains with GNG3: view

No data available for Gene Families for GNG3 Gene

Function for GNG3 Gene

Molecular function for GNG3 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein) gamma 3 subunit,expressed in brain
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding --
GO:0003924 GTPase activity TAS 10075696
GO:0004871 signal transducer activity IEA --
GO:0031702 type 1 angiotensin receptor binding IEA --
genes like me logo Genes that share ontologies with GNG3: view
genes like me logo Genes that share phenotypes with GNG3: view

Animal Models for GNG3 Gene

MGI Knock Outs for GNG3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GNG3 Gene

Localization for GNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG3 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG3 Gene COMPARTMENTS Subcellular localization image for GNG3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 3
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG3: view

Pathways for GNG3 Gene

SuperPathways for GNG3 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 fMLP Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with GNG3: view

Gene Ontology (GO) - Biological Process for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10075696
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with GNG3: view

Compounds for GNG3 Gene

(5) Tocris Compounds for GNG3 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(3) HMDB Compounds for GNG3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG3: view

Transcripts for GNG3 Gene

mRNA/cDNA for GNG3 Gene

Unigene Clusters for GNG3 Gene

Guanine nucleotide binding protein (G protein), gamma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG3 Gene

No ASD Table

Relevant External Links for GNG3 Gene

GeneLoc Exon Structure for
GNG3
ECgene alternative splicing isoforms for
GNG3

Expression for GNG3 Gene

mRNA expression in normal human tissues for GNG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG3 Gene

This gene is overexpressed in Brain - Cortex (7.2), Brain - Frontal Cortex (BA9) (6.6), Brain - Anterior cingulate cortex (BA24) (6.5), Brain - Amygdala (4.9), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNG3 Gene

SOURCE GeneReport for Unigene cluster for GNG3 Gene Hs.179915

genes like me logo Genes that share expressions with GNG3: view

No data available for mRNA Expression by UniProt/SwissProt for GNG3 Gene

Orthologs for GNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG3 35
  • 100 (n)
  • 100 (a)
GNG3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG3 35
  • 97.78 (n)
  • 100 (a)
GNG3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG3 35
  • 96 (n)
  • 100 (a)
GNG3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng3 35
  • 94.67 (n)
  • 100 (a)
Gng3 16
Gng3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng3 35
  • 96 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng3 35
  • 80 (n)
  • 92 (a)
zebrafish
(Danio rerio)
Actinopterygii gng3 35
  • 85.33 (n)
  • 93.33 (a)
gng3 36
  • 93 (a)
OneToOne
Species with no ortholog for GNG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG3 Gene

ENSEMBL:
Gene Tree for GNG3 (if available)
TreeFam:
Gene Tree for GNG3 (if available)

Paralogs for GNG3 Gene

Paralogs for GNG3 Gene

Selected SIMAP similar genes for GNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG3: view

Variants for GNG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG3 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv348 CNV Loss 18451855

Relevant External Links for GNG3 Gene

HapMap Linkage Disequilibrium report
GNG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GNG3 Gene

Disorders for GNG3 Gene

No disorders were found for GNG3 Gene.

No data available for UniProtKB/Swiss-Prot for GNG3 Gene

Publications for GNG3 Gene

  1. The G protein subunit gene families. (PMID: 10644457) Downes G.B. … Gautam N. (Genomics 1999) 2 3
  2. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PMID: 17185339) Fowler C.E. … Slesinger P.A. (J. Physiol. (Lond.) 2007) 3

Products for GNG3 Gene

Sources for GNG3 Gene

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