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Aliases for GNG3 Gene

Aliases for GNG3 Gene

  • G Protein Subunit Gamma 3 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 3 2 5
  • Guanine Nucleotide-Binding Protein Gamma-3 Subunit 2
  • NBP Gamma-3 2
  • GNGT3 4

External Ids for GNG3 Gene

Previous GeneCards Identifiers for GNG3 Gene

  • GC11P064988
  • GC11P064050
  • GC11P062250
  • GC11P062231
  • GC11P062475
  • GC11P058803

Summaries for GNG3 Gene

Entrez Gene Summary for GNG3 Gene

  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

GeneCards Summary for GNG3 Gene

GNG3 (G Protein Subunit Gamma 3) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTPase activity and G-protein coupled receptor binding. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG3 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG3 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG3 Gene

Genomics for GNG3 Gene

Regulatory Elements for GNG3 Gene

Promoters for GNG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNG3 Gene

Chromosome:
11
Start:
62,706,422 bp from pter
End:
62,709,206 bp from pter
Size:
2,785 bases
Orientation:
Plus strand

Genomic View for GNG3 Gene

Genes around GNG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG3 Gene

Proteins for GNG3 Gene

  • Protein details for GNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63215-GBG3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Protein Accession:
    P63215
    Secondary Accessions:
    • B2R4S7
    • P29798
    • Q61014

    Protein attributes for GNG3 Gene

    Size:
    75 amino acids
    Molecular mass:
    8305 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG3 Gene

Proteomics data for GNG3 Gene at MOPED

Post-translational modifications for GNG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG3 Gene

Domains & Families for GNG3 Gene

Protein Domains for GNG3 Gene

Suggested Antigen Peptide Sequences for GNG3 Gene

Graphical View of Domain Structure for InterPro Entry

P63215

UniProtKB/Swiss-Prot:

GBG3_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG3: view

No data available for Gene Families for GNG3 Gene

Function for GNG3 Gene

Molecular function for GNG3 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein) gamma 3 subunit,expressed in brain
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG3: view
genes like me logo Genes that share phenotypes with GNG3: view

Animal Models for GNG3 Gene

MGI Knock Outs for GNG3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG3 Gene

Localization for GNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG3 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG3 Gene COMPARTMENTS Subcellular localization image for GNG3 gene
Compartment Confidence
cytosol 4
plasma membrane 4
extracellular 3
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0030425 dendrite IEA --
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with GNG3: view

Pathways & Interactions for GNG3 Gene

SuperPathways for GNG3 Gene

Superpath Contained pathways
1 Circadian entrainment
2 Development Angiotensin activation of ERK
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 G-protein activation
genes like me logo Genes that share pathways with GNG3: view

SIGNOR curated interactions for GNG3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GNG3: view

Drugs & Compounds for GNG3 Gene

(3) Drugs for GNG3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG3 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG3: view

Transcripts for GNG3 Gene

mRNA/cDNA for GNG3 Gene

Unigene Clusters for GNG3 Gene

Guanine nucleotide binding protein (G protein), gamma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG3 Gene

No ASD Table

Relevant External Links for GNG3 Gene

GeneLoc Exon Structure for
GNG3
ECgene alternative splicing isoforms for
GNG3

Expression for GNG3 Gene

mRNA expression in normal human tissues for GNG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG3 Gene

This gene is overexpressed in Brain - Cortex (x7.2), Brain - Frontal Cortex (BA9) (x6.6), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Amygdala (x4.9), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for GNG3 Gene

This gene is overexpressed in Frontal cortex (35.7) and Brain (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG3 Gene



SOURCE GeneReport for Unigene cluster for GNG3 Gene Hs.179915

genes like me logo Genes that share expression patterns with GNG3: view

Protein tissue co-expression partners for GNG3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG3 Gene

Orthologs for GNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG3 35
  • 97.78 (n)
  • 100 (a)
GNG3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG3 35
  • 96 (n)
  • 100 (a)
GNG3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng3 35
  • 94.67 (n)
  • 100 (a)
Gng3 16
Gng3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNG3 35
  • 100 (n)
  • 100 (a)
GNG3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng3 35
  • 96 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia GNG3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng3 35
  • 80 (n)
  • 92 (a)
zebrafish
(Danio rerio)
Actinopterygii gng3 35
  • 85.33 (n)
  • 93.33 (a)
gng3 36
  • 93 (a)
OneToOne
Species with no ortholog for GNG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG3 Gene

ENSEMBL:
Gene Tree for GNG3 (if available)
TreeFam:
Gene Tree for GNG3 (if available)

Paralogs for GNG3 Gene

Paralogs for GNG3 Gene

(10) SIMAP similar genes for GNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG3: view

Variants for GNG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG3 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv348 CNV Loss 18451855

Variation tolerance for GNG3 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG3 Gene

HapMap Linkage Disequilibrium report
GNG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GNG3 Gene

Disorders for GNG3 Gene

Relevant External Links for GNG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG3

No disorders were found for GNG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG3 Gene

Publications for GNG3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The G protein subunit gene families. (PMID: 10644457) Downes G.B. … Gautam N. (Genomics 1999) 2 3
  3. Interaction of G-protein I^I^ complex with chromatin modulates GPCR-dependent gene regulation. (PMID: 23326349) Bhatnagar A. … Karnik S.S. (PLoS ONE 2013) 3
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  5. Regulation of Golgi structure and secretion by receptor-induced G protein I^I^ complex translocation. (PMID: 20534534) Saini D.K. … Gautam N. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for GNG3 Gene

Sources for GNG3 Gene

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