Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNG3 Gene

protein-coding GIFtS: 56
GCID: GC11P062475

guanine nucleotide binding protein (G protein), gamma 3

Explore 4 diseases affiliated with
GNG3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 3¹ ²
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-3²
Guanine Nucleotide-Binding Protein Gamma-3 Subunit²
NBP Gamma-3²
GNGT3³

External Ids:	HGNC: 4405¹	Entrez Gene: 2785²	Ensembl: ENSG00000162188⁷	OMIM: 608941⁵	UniProtKB: P63215³

Export aliases for GNG3 gene to outside databases

Previous GC identifers: GC11P064988 GC11P064050 GC11P062726 GC11P062250 GC11P062231 GC11P058803

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNG3:

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and

gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this

particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory

complexes. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

summary for GNG3:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; in addition, some

Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and

Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNG3 gene promoter:
TBP NF-1 NF-1/L p300 MyoD XBP-1 Ik-3 GATA-1 Max TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNG3 promoter sequence

Search SABiosciences Chromatin IP Primers for GNG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11p11

GNG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P062475: view genomic region (about GC identifiers)

Start:	62,475,114 bp from pter	End:	62,476,678 bp from pter
Size:	1,565 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor

Size: 75 amino acids; 8305 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Secondary accessions: B2R4S7 P29798 Q61014

Explore the universe of human proteins at neXtProt for GNG3: NX_P63215

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P63215

GNG3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036334.1

ENSEMBL proteins:

ENSP00000294117

Reactome Protein details: P63215
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GNG3 OriGene Custom Protein Services for GNG3
	GenScript Custom Purified and Recombinant Proteins Services for GNG3
	Novus Biologicals GNG3 Protein Novus Biologicals GNG3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005834	heterotrimeric G-protein complex	IEA	--
GO:0005886	plasma membrane	TAS	--

GNG3 for ontologies About GeneDecksing

GNG3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for GNG3
	GenScript Custom Superior Antibodies Services for GNG3
	Novus Biologicals GNG3 Antibody
	Search for Antibodies for GNG3 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for GNG3

Assay Products for GNG3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GNG3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNG3 for domains About GeneDecksing

2 InterPro domains/families:

IPR001770 Gprotein-gamma

IPR015898 G-protein_gamma-like_dom

Graphical View of Domain Structure for InterPro Entry P63215

ProtoNet protein and cluster: P63215

1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature

UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215

Similarity: Belongs to the G protein gamma family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

Genatlas biochemistry entry for GNG3:

guanine nucleotide binding protein (G protein) gamma 3 subunit,expressed in brain

miRNA Products:		OriGene 3'-UTR Clone: GNG3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG3
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG3:
		hsa-miR-607 hsa-miR-136 hsa-miR-125a-3p hsa-miR-4312 hsa-miR-218 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: GNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG3 (see all 4) OriGene shRNA RFP: GNG3 OriGene siRNA: GNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNG3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNG3 (NM_012202)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNG3
		Search LifeMap BioReagents cell lines for GNG3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	--	--
GO:0003924	GTPase activity	TAS	10075696
GO:0004871	signal transducer activity	IEA	--
GO:0031702	type 1 angiotensin receptor binding	--	--

GNG3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Gng3^tm1.1Rbs for GNG3
     7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gng3):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	mortality/aging
nervous system	no phenotypic analysis

GNG3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/67 super-pathways (see all 67) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

8/13 pathways (see all 13)
G beta:gamma signalling through PLC beta	1.00	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.55
Presynaptic function of Kainate receptors	0.95	G-protein activation	0.55
Prostacyclin signalling through prostacyclin receptor	0.77	Glucagon-type ligand receptors	0.52
G-protein beta:gamma signalling	0.71	G-Protein Signaling through Tubby Protein	0.38

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/31 EMD Millipore Pathways for GNG3 (see all 31)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling

5/70 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG3 (see all 70)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

5/34 GeneGo (Thomson Reuters) Pathways for GNG3 (see all 34)

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

3 BioSystems Pathways for GNG3

	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways

5/48 Reactome Pathways for GNG3 (see all 48)

	G alpha (12/13) signalling events
	Platelet homeostasis
	G protein gated Potassium channels
	G alpha (z) signalling events
	Inwardly rectifying K+ channels

1 PharmGKB Pathway for GNG3

Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for GNG3):

	Chemokine signaling pathway
	Glutamatergic synapse
	Cholinergic synapse
	Taste transduction

GNG3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNG3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for GNG3 (P63215³ ENSP00000294117⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
GNB3	P16520³, ENSP00000229264⁴	I2D: score=2 STRING: ENSP00000229264
GNB4	Q9HAV0³, ENSP00000232564⁴	I2D: score=2 STRING: ENSP00000232564
GNB2	P62879³, ENSP00000305260⁴	I2D: score=2 STRING: ENSP00000305260
GNB5	O14775³, ENSP00000261837⁴	I2D: score=2 STRING: ENSP00000261837

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	10075696
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006184	GTP catabolic process	TAS	10075696
GO:0007186	G-protein coupled receptor signaling pathway	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	--	--

GNG3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNG3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Gallein	Inhibitor of betagamma signaling	[2103-64-2]
GRK2i	GRK2 inhibitory polypeptide. Gbetagamma antagonist	[148505-03-7]

3 HMDB Compounds for GNG3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNG3 / GBG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNG3 gene:

NM_012202.4

Unigene Clusters for GNG3:

Guanine nucleotide binding protein (G protein), gamma 3

Hs.179915 [show with all ESTs], Hs.740581 [show with all ESTs]

Unigene Representative Sequences: BQ068004, BF310373

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000294117(uc001nuv.3)

miRNA Products:		OriGene 3'-UTR Clone: GNG3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG3
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG3:
		hsa-miR-607 hsa-miR-136 hsa-miR-125a-3p hsa-miR-4312 hsa-miR-218 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: GNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG3 (see all 4) OriGene shRNA RFP: GNG3 OriGene siRNA: GNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNG3 (NM_012202)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG3

Additional cDNA sequence: AF493871.1

5 DOTS entries:

DT.100681232 DT.111937 DT.120755092 DT.75101387 DT.95135329

24/50 AceView cDNA sequences (see all 50):

H23781 CR620191 BM693570 AF075042 AF493871 H40975 CR625883 CK004460

BG701285 BQ721912 CK004020 BI754286 AF087900 BF943818 BI823716 BF947095

CK003545 NM_012202 BM926337 BG705515 AF092129 BI545438 AW900596 AW161355

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGGTTATC

About this image

GNG3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Gut Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNG3

SOURCE GeneReport for Unigene clusters: Hs.179915 Hs.740581

SABiosciences Expression via Pathway-Focused PCR Array including GNG3:

Alzheimer's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GNG3 gene from 1/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	gng3¹	guanine nucleotide binding protein (G protein), gamma more	85.33(n) 93.33(a)		114462 NM_131841.2 NP_571916.1

ENSEMBL Gene Tree for GNG3 (if available)
TreeFam Gene Tree for GNG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNG3 gene

GNG2² GNG7² GNG10² GNG8² GNG5² GNG5P2² GNG4² GNG12²

11 SIMAP similar genes for GNG3 using alignment to 1 protein entry: GBG3_HUMAN:

GNG2 GNG8 GNG7 GNG4 DKFZp762E193 GNG12

GNG10 GNG5 GNG11 GNGT2 GNGT1

GNG3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140109104^1,2		--	62473122(+)	`TGACT-/CCTTTC`	7	--	us2k¹ int¹		0	--	--	--	--
rs186680211^1,2		--	62473136(+)	`AGGGAC/GGTGGG`	7	--	us2k¹ int¹		0	--	--	--	--
rs142482979^1,2		--	62473195(+)	`TAGCAA/CAGTCA`	7	--	int¹ us2k¹		0	--	--	--	--
rs191835830^1,2		--	62473231(+)	`CAAATC/GATTGT`	7	--	us2k¹ int¹		0	--	--	--	--
rs182784001^1,2		--	62473507(+)	`CAGTAA/GCCTTA`	7	--	int¹ us2k¹		0	--	--	--	--
rs188841555^1,2		--	62473518(+)	`GAGTAG/TCCACA`	7	--	int¹ us2k¹		0	--	--	--	--
rs77741515^1,2		--	62473533(+)	`CTTCCC/GGAGTT`	7	--	int¹ us2k¹		0	--	--	--	--
rs56135662^1,2	C,	--	62473548(+)	`CTCTCC/TGCCTC`	7	--	us2k¹ int¹		4		NA WA EA	360
rs192881882^1,2		--	62473676(+)	`CTACCC/TAATCG`	7	--	int¹ ut5¹ us2k¹		0	--	--	--	--
rs112877243^1,2	C,	--	62473702(+)	`CAGCCC/TGCCGG`	7	--	us2k¹ int¹ ut5¹		1		WA	2

HapMap Linkage Disequilibrium report for GNG3 (62475114 - 62476678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GNG3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG3

DNA2.0 Custom Variant and Variant Library Synthesis for GNG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNG3 for disorders           About GeneDecksing

OMIM gene information: 608941    OMIM disorders: --

4 diseases for GNG3:    About MalaCards

seizures huntington's disease colorectal cancer breast cancer

Export disorders for GNG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNG3 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with GNG3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PubMed id 10819326)^{1, 2} Hurowitz E.H....Shizuya H. (2000)
The G protein subunit gene families. (PubMed id 10644457)^{1, 3} Downes G.B. and Gautam N. (1999)
Regulation of Golgi structure and secretion by recept or-induced G protein betagamma complex translocation. (PubMed id 20534534)¹ Saini D.K....Gautam N. (2010)
Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)¹ Poon L.S....Wong Y.H. (2009)
Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)¹ Howlett A.C....Willardson B.M. (2009)
Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)¹ Fowler C.E....Slesinger P.A. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Characterization of heterotrimeric G protein complexes in rice plasma membrane. (PubMed id 15078334)¹ Kato C....Iwasaki Y. (2004)
Mice with deficiency of G protein gamma3 are lean and have seizures. (PubMed id 15314181)¹ Schwindinger W.F....Robishaw J.D. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2785	HGNC: 4405	AceView: GNG3	Ensembl:ENSG00000162188	euGenes: HUgn2785
ECgene: GNG3	Kegg: 2785	H-InvDB: GNG3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNG3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GNG3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GNG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GNG3 gene:
Search GeneIP for patents involving GNG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for GNG3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG3
	OriGene Protein Over-expression Lysate for GNG3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GNG3		OriGene 3'-UTR Clone for GNG3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GNG3		OriGene Custom Protein Services for GNG3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNG3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG3

	GenScript Custom Purified and Recombinant Proteins Services for GNG3		GenScript cDNA clones with any tag delivered in your preferred vector for GNG3
	GenScript Custom Assay Services for GNG3		GenScript Custom Superior Antibodies Services for GNG3
	GenScript Custom overexpressing Cell Line Services for GNG3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GNG3 promoter
	Search Chromatin IP Primers for GNG3
	RT² qPCR Primer Assay in human, mouse, rat GNG3
	Search GNC Networks for GNG3
	SABiosciences PCR Arrays including human, mouse, rat GNG3

Tocris compounds for GNG3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GNG3 antibodies
	GNG3 proteins
	GNG3 lysates

	Search for Antibodies for GNG3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for GNG3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GNG3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG3

	SwitchGear 3'UTR luciferase reporter plasmids for GNG3
	SwitchGear Promoter luciferase reporter plasmids for GNG3

Search ThermoFisher Antibodies for GNG3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GNG3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GNG3 Gene

guanine nucleotide binding protein (G protein), gamma 3

Aliases
for GNG3 gene

Summaries
for GNG3 gene

Genomic Views
for GNG3 gene

Proteins
for GNG3 gene

Protein Domains /
Families
for GNG3 gene

Function
for GNG3 gene

Pathways & Interactions
for GNG3 gene

Drugs & Compounds
for GNG3 gene

Transcripts
for GNG3 gene

Expression
for GNG3 gene

Orthologs
for GNG3 gene

Paralogs
for GNG3 gene

Genomic Variants
for GNG3 gene

Disorders / Diseases
for GNG3 gene

Publications
for GNG3 gene

External Searches for GNG3 gene

Genome Databases showing GNG3 gene

Other Databases showing GNG3 gene

Specialized Databases showing GNG3 gene

Intellectual Property
for GNG3 gene

Products
for GNG3 gene

View Random Gene

Advanced Search

Export list of displayed genes

GNG3 Gene

guanine nucleotide binding protein (G protein), gamma 3

Aliasesfor GNG3 gene

Summariesfor GNG3 gene

Genomic Viewsfor GNG3 gene

Proteinsfor GNG3 gene

Protein Domains /Familiesfor GNG3 gene

Functionfor GNG3 gene

Pathways & Interactionsfor GNG3 gene

Drugs & Compoundsfor GNG3 gene

Transcriptsfor GNG3 gene

Expression for GNG3 gene

Orthologsfor GNG3 gene

Paralogsfor GNG3 gene

Genomic Variantsfor GNG3 gene

Disorders / Diseasesfor GNG3 gene

Publicationsfor GNG3 gene

External Searches for GNG3 gene

Genome Databases showing GNG3 gene

Other Databases showing GNG3 gene

Specialized Databases showing GNG3 gene

Intellectual Propertyfor GNG3 gene

Productsfor GNG3 gene

View Random Gene

Aliases
for GNG3 gene

Summaries
for GNG3 gene

Genomic Views
for GNG3 gene

Proteins
for GNG3 gene

Protein Domains /
Families
for GNG3 gene

Function
for GNG3 gene

Pathways & Interactions
for GNG3 gene

Drugs & Compounds
for GNG3 gene

Transcripts
for GNG3 gene

Expression
for GNG3 gene

Orthologs
for GNG3 gene

Paralogs
for GNG3 gene

Genomic Variants
for GNG3 gene

Disorders / Diseases
for GNG3 gene

Publications
for GNG3 gene

Intellectual Property
for GNG3 gene

Products
for GNG3 gene