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GNG3 Gene

protein-coding   GIFtS: 55
GCID: GC11P062475

Guanine Nucleotide Binding Protein (G Protein), Gamma 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 31 2
Guanine Nucleotide-Binding Protein Gamma-3 Subunit1 2
NBP Gamma-31 2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-32
GNGT33

External Ids:    HGNC: 44051   Entrez Gene: 27852   Ensembl: ENSG000001621887   OMIM: 6089415   UniProtKB: P632153   
ORGUL members:         

Export aliases for GNG3 gene to outside databases

Previous GC identifers: GC11P064988 GC11P064050 GC11P062726 GC11P062250 GC11P062231 GC11P058803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNG3 Gene:
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and
gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this
particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and
stimulatory complexes. (provided by RefSeq, Jan 2012)

GeneCards Summary for GNG3 Gene:
GNG3 (guanine nucleotide binding protein (G protein), gamma 3) is a protein-coding gene. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG3 gene promoter:
         TBP   NF-1   NF-1/L   p300   MyoD   XBP-1   Ik-3   GATA-1   Max   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNG3 promoter sequence
   Search Chromatin IP Primers for GNG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11p11

GNG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062475:  view genomic region     (about GC identifiers)

Start:
62,475,114 bp from pter      End:
62,476,678 bp from pter
Size:
1,565 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor  
Size: 75 amino acids; 8305 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Secondary accessions: B2R4S7 P29798 Q61014

Explore the universe of human proteins at neXtProt for GNG3: NX_P63215

Explore proteomics data for GNG3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036334.1  
    ENSEMBL proteins: 
     ENSP00000294117  
    Reactome Protein details: P63215

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for GNG3 (2 products) 

     
    antibodies-online peptides for GNG3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P63215

    ProtoNet protein and cluster: P63215

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG3_HUMAN, P63215
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG3_HUMAN, P63215
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNG3:
    guanine nucleotide binding protein (G protein) gamma 3 subunit,expressed in brain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10075696
    GO:0004871signal transducer activity IEA--
         
    Find genes that share ontologies with GNG3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gng3):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis 

    Find genes that share phenotypes with GNG3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gng3tm1.1Rbs for GNG3

       genOway: Develop your customized and physiologically relevant rodent model for GNG3

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate GNG3:
    hsa-miR-607 hsa-miR-136 hsa-miR-125a-3p hsa-miR-4312 hsa-miR-218 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidGNG3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBG3_HUMAN, P63215: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular3
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with GNG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNG3 About   (see all 63)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58


    Find genes that share SuperPaths with GNG3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG3 (see all 70)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG3 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG3
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell


    Selected Reactome Pathways for GNG3 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    1 PharmGKB Pathway for GNG3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNG3) (see all 13):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Array including GNG3: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GNG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG3 (P632153 ENSP000002941174) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB3P165203, ENSP000002292644I2D: score=2 STRING: ENSP00000229264
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    GNB2P628793, ENSP000003052604I2D: score=2 STRING: ENSP00000305260
    GNB5O147753, ENSP000002618374I2D: score=2 STRING: ENSP00000261837
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10075696
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS10075696
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--

    Find genes that share ontologies with GNG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNG3 gene: 
    NM_012202.4  

    Unigene Cluster for GNG3:

    Guanine nucleotide binding protein (G protein), gamma 3
    Hs.179915  [show with all ESTs]
    Unigene Representative Sequence: BQ068004
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000294117(uc001nuv.3)
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    Additional mRNA sequence: 

    AF075042.1 AF087900.1 AF092129.1 AK311933.1 BC015563.2 

    5 DOTS entries:

    DT.100681232  DT.111937  DT.120755092  DT.75101387  DT.95135329 

    Selected AceView cDNA sequences (see all 50):

    CR620191 AF493871 H40975 CR625883 BM693570 AF075042 H23781 BF943818 
    BC015563 CK003545 BM926337 BI915107 BG705515 BG701285 BQ721912 CK004020 
    BI754286 AW900596 BF947095 AW161355 CB565928 CK004460 AF092129 AF087900 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGTTATC
    GNG3 Expression
    About this image


    GNG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebellum
    GNG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179915
        Pathway & Disease-focused RT2 Profiler PCR Array including GNG3: 
              Alzheimer's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GNG3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng31 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 94.67(n)1
    100(a)1
      19 (5.76 cM)5
    147041  NM_010316.31  NP_034446.11 
     88369295 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gng31 guanine nucleotide binding protein (G protein), gamma more 80(n)
    92(a)
      100038286  NM_001171609.1  NP_001165080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gng31 guanine nucleotide binding protein (G protein), gamma more 85.33(n)
    93.33(a)
      114462  NM_131841.2  NP_571916.1 


    ENSEMBL Gene Tree for GNG3 (if available)
    TreeFam Gene Tree for GNG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNG3 gene
    GNG22  GNG72  GNG102  GNG82  GNG5P22  GNG52  GNG42  GNG122  
    10 SIMAP similar genes for GNG3 using alignment to 1 protein entry:     GBG3_HUMAN:
    GNG2    GNG8    GNG7    GNG4    GNG12    GNG10
    GNG5    GNG11    GNGT2    GNGT1

    Find genes that share paralogs with GNG3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv348CNV Loss18451855
    nsv897623CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608941    OMIM disorders: --


    Find genes that share disorders with GNG3           About GenesLikeMe


    Export disorders for GNG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNG3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with GNG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PubMed id 10819326)1, 2 Hurowitz E.H....Shizuya H. (DNA Res. 2000)
    3. The G protein subunit gene families. (PubMed id 10644457)1, 3 Downes G.B. and Gautam N. (Genomics 1999)
    4. Interaction of G-protein I^I^ complex with chromatin modulates GPCR-dependent gene regulation. (PubMed id 23326349)1 Bhatnagar A....Karnik S.S. (PLoS ONE 2013)
    5. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    6. Regulation of Golgi structure and secretion by receptor-induced G protein I^I^ complex translocation. (PubMed id 20534534)1 Saini D.K....Gautam N. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (Cell. Signal. 2009)
    8. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    9. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (J. Physiol. (Lond.) 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2785 HGNC: 4405 AceView: GNG3 Ensembl:ENSG00000162188 euGenes: HUgn2785
    ECgene: GNG3 Kegg: 2785 H-InvDB: GNG3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNG3 gene:
    Search GeneIP for patents involving GNG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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