Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNG2 Gene

protein-coding GIFtS: 61
GCID: GC14P052327

guanine nucleotide binding protein (G protein), gamma 2

Explore 12 diseases affiliated with
GNG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 2¹ ²
G Gamma-I² ³
Guanine Nucleotide Binding Protein Gamma 2²
Guanine Nucleotide-Binding Protein G(I)/G(O) Gamma-2 Subunit²
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-2²

External Ids:	HGNC: 4404¹	Entrez Gene: 54331²	Ensembl: ENSG00000186469⁷	OMIM: 606981⁵	UniProtKB: P59768³

Export aliases for GNG2 gene to outside databases

Previous GC identifers: GC14P049702 GC14M046231 GC14M050426 GC14P050303 GC14P051383 GC14P032487

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNG2:

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in

signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different

signal molecules. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction (By similarity)

summary for GNG2:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; in addition, some

Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and

Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for GNG2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNG2 promoter sequence

Search SABiosciences Chromatin IP Primers for GNG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q21

GNG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P052327: view genomic region (about GC identifiers)

Start:	52,292,913 bp from pter	End:	52,446,060 bp from pter
Size:	153,148 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

Size: 71 amino acids; 7850 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and

GNG2 interacts with PTH1R (via C-terminus)

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Secondary accessions: Q5JPE2 Q6P9A9

Explore the universe of human proteins at neXtProt for GNG2: NX_P59768

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P59768

GNG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001230702.1 NP_001230703.1 NP_444292.1

ENSEMBL proteins:

ENSP00000451279 ENSP00000450904 ENSP00000450758 ENSP00000450586 ENSP00000334448

ENSP00000451102 ENSP00000451231 ENSP00000452014 ENSP00000451576 ENSP00000451536

Reactome Protein details: P59768
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GNG2 OriGene Protein Over-expression Lysate: GNG2 OriGene Custom Protein Services for GNG2
	GenScript Custom Purified and Recombinant Proteins Services for GNG2
	Novus Biologicals GNG2 Protein Novus Biologicals GNG2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005834	heterotrimeric G-protein complex	ISS	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	ISS	--

GNG2 for ontologies About GeneDecksing

GNG2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for GNG2
	GenScript Custom Superior Antibodies Services for GNG2
	Novus Biologicals GNG2 Antibodies
	Search for Antibodies for GNG2 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for GNG2

Assay Products for GNG2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GNG2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNG2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001770 Gprotein-gamma

IPR015898 G-protein_gamma-like_dom

Graphical View of Domain Structure for InterPro Entry P59768

ProtoNet protein and cluster: P59768

1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768

Similarity: Belongs to the G protein gamma family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: GNG2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG2 (see all 62):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-379* hsa-miR-29a hsa-miR-1258 hsa-miR-105 hsa-miR-124 hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: GNG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG2 (see all 4) OriGene shRNA RFP: GNG2 OriGene siRNA: GNG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNG2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNG2 (NM_053064)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNG2
		Search LifeMap BioReagents cell lines for GNG2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--

GNG2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GNG2:

Decreased melanin production

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/77 super-pathways (see all 77) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

8/13 pathways (see all 13)
G beta:gamma signalling through PLC beta	1.00	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.55
Presynaptic function of Kainate receptors	0.95	G-protein activation	0.55
Prostacyclin signalling through prostacyclin receptor	0.77	Glucagon-type ligand receptors	0.52
G-protein beta:gamma signalling	0.71	G-Protein Signaling through Tubby Protein	0.38

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/31 EMD Millipore Pathways for GNG2 (see all 31)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling

5/70 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG2 (see all 70)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

5/34 GeneGo (Thomson Reuters) Pathways for GNG2 (see all 34)

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

5/13 BioSystems Pathways for GNG2 (see all 13)

	Myometrial Relaxation and Contraction Pathways
	Nicotine Activity on Dopaminergic Neurons
	Calcium Regulation in the Cardiac Cell
	TSH signaling pathway
	Plasma membrane estrogen receptor signaling

5/48 Reactome Pathways for GNG2 (see all 48)

	G alpha (12/13) signalling events
	Platelet homeostasis
	G protein gated Potassium channels
	G alpha (z) signalling events
	Inwardly rectifying K+ channels

2 PharmGKB Pathways for GNG2

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

3 Kegg Pathways (Kegg details for GNG2):

	Chemokine signaling pathway
	Glutamatergic synapse
	Cholinergic synapse

GNG2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/383 Interacting proteins for GNG2 (P59768^{2, 3} ENSP00000334448⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 383)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAI1	P63096²^,³, ENSP00000343027⁴	MINT-8189440 I2D: score=1 STRING: ENSP00000343027
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
CACNA1H	O95180³, ENSP00000334198⁴	I2D: score=1 STRING: ENSP00000334198
CHRM2	P08172³, ENSP00000319984⁴	I2D: score=1 STRING: ENSP00000319984
GNAS	Q5JWF2³, ENSP00000360141⁴	I2D: score=1 STRING: ENSP00000360141

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	ISS	--
GO:0007268	synaptic transmission	TAS	--
GO:0007596	blood coagulation	TAS	--

GNG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNG2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Gallein	Inhibitor of betagamma signaling	[2103-64-2]
GRK2i	GRK2 inhibitory polypeptide. Gbetagamma antagonist	[148505-03-7]

3 HMDB Compounds for GNG2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 DrugBank Compound for GNG2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Halothane	2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)	151-67-7	target	other/unknown	15175324 12657848 11961592 12826849 10913255

Search CenterWatch for drugs/clinical trials and news about GNG2 / GBG2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNG2 gene (3 alternative transcripts):

NM_001243773.1 NM_001243774.1 NM_053064.4

Unigene Clusters for GNG2:

Guanine nucleotide binding protein (G protein), gamma 2

Hs.187772 [show with all ESTs], Hs.709082 [show with all ESTs]

Unigene Representative Sequences: NM_053064, BC041446

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553432 ENST00000556522 ENST00000557376 ENST00000553560 ENST00000554832

ENST00000553299 ENST00000335281(uc010aoc.2 uc001wzi.3 uc021rte.1 uc001wzj.3)

ENST00000557208 ENST00000555472 ENST00000556766 ENST00000554840 ENST00000554736

ENST00000556752(uc001wzh.3 uc001wzk.3) ENST00000556471 ENST00000554875

miRNA Products:		OriGene 3'-UTR Clone: GNG2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG2 (see all 62):
		hsa-miR-411* hsa-miR-3678-3p hsa-miR-379* hsa-miR-29a hsa-miR-1258 hsa-miR-105 hsa-miR-124 hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: GNG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG2 (see all 4) OriGene shRNA RFP: GNG2 OriGene siRNA: GNG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNG2 (NM_053064)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG2

Additional cDNA sequence: BC041446.1

19 DOTS entries:

DT.115864 DT.97767221 DT.95101239 DT.120792866 DT.100812746 DT.97773147 DT.100812745 DT.120792977

DT.95073569 DT.100640890 DT.120793040 DT.401432 DT.99932825 DT.100658238 DT.100812750 DT.120793046

DT.92355998 DT.95113831 DT.95206964

24/226 AceView cDNA sequences (see all 226):

BX332417 AA977755 BF978158 AI932610 AI760175 AI818799 BU431384 BQ718537

N66425 BQ674586 BQ950274 C01898 AA353597 BQ025819 BX109709 AA987952

AI422400 AF493870 BM479054 AW160428 H97059 AU253254 BM917190 AI459446

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GNG2 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:							-		-		-						-		-		-				-
SP2:													-				-				-		-		-				-
SP3:													-				-		-		-		-		-				-
SP4:													-		-		-		-		-		-		-				-
SP5:													-				-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for GNG2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAATGTAT

About this image

GNG2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Epiblast-like cells (Reconstitution of mo...)

See GNG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNG2

SOURCE GeneReport for Unigene clusters: Hs.187772 Hs.709082

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768

Tissue specificity: Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain

SABiosciences Custom PCR Arrays for GNG2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GNG2 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNG2¹	guanine nucleotide binding protein (G protein), gamma more	85.92(n) 98.59(a)		423581 NM_001097528.1 NP_001090997.1
lizard (Anolis carolinensis)	Reptilia	GNG2⁶	--	99(a)	1 ↔ 1	GL344470.1(37997-40943)
zebrafish (Danio rerio)	Actinopterygii	LOC100332296¹	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit more	82.63(n) 94.37(a)		100332296 XM_002664141.2 XP_002664187.1

ENSEMBL Gene Tree for GNG2 (if available)
TreeFam Gene Tree for GNG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNG2 gene

GNG7² GNG10² GNG3² GNG8² GNG5² GNG5P2² GNG4² GNG12²

11 SIMAP similar genes for GNG2 using alignment to 6 protein entries: GBG2_HUMAN (see all proteins):

GNG8 GNG4 GNG3 GNG7 DKFZp762E193 GNG12

GNG5 GNG10 GNGT2 GNG11 GNGT1

GNG2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4468527^1,2	C,F,A,H,	--	52325131(+)	`GAACTG/AATTAA`	3	--	us2k¹		17		NS EA NA WA CSA	795
rs112602456^1,2	C,	--	52325171(+)	`TATTGT/ATTGAA`	3	--	us2k¹		1		CSA	2
rs7147543^1,2	C,F,H,	--	52325213(+)	`TACCAA/GCCTAT`	3	--	us2k¹		10		NS EA NA WA	768
rs149324645^1,2		--	52325290(+)	`AAAAAA/TTTACT`	3	--	us2k¹		0	--	--	--	--
rs144606328^1,2		--	52325342(+)	`AATTAA/GCCATA`	3	--	us2k¹		0	--	--	--	--
rs7148347^1,2	C,F,H,	--	52325397(+)	`ACTTGG/CCATCA`	3	--	us2k¹		20		NA NS EA WA	2058
rs115614484^1,2		--	52325481(+)	`CATGTG/TGGTGG`	3	--	us2k¹		0	--	--	--	--
rs10133431^1,2	C,H	--	52325521(+)	`TTTCTA/GTCTGC`	3	--	us2k¹		4		NS EA	416
rs188291442^1,2		--	52325541(+)	`AAAGCA/TAGTTG`	3	--	us2k¹		0	--	--	--	--
rs182301322^1,2		--	52325569(+)	`ATCAAC/TCCATT`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GNG2 (52292913 - 52446060 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for GNG2
     2 CNVs: 101952 101953
     3 Indels: 11727 11726 45282
     1 Inversion: 37159

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG2

DNA2.0 Custom Variant and Variant Library Synthesis for GNG2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNG2 for disorders           About GeneDecksing

OMIM gene information: 606981    OMIM disorders: --

12 diseases for GNG2:    About MalaCards

hemiplegic migraine familial hemiplegic migraine migraine acute lymphoblastic leukemia

lymphoblastic leukemia agammaglobulinemia thrombosis leukemia

melanoma huntington's disease colorectal cancer breast cancer

Human Genome Epidemiology (HuGE) Navigator: GNG2 (3 documents)

Export disorders for GNG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNG2 gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with GNG2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. (PubMed id 10833460)^{1, 2, 3, 9} Modarressi M.H.... Wolfe J. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Topography of Gng2- and NetrinG2-expression suggests a n insular origin of the human claustrum. (PubMed id 22957104)¹ Pirone A....Castagna M. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The WD40 repeat protein WDR26 binds Gbg and promotes G bg-dependent signal transduction and leukocyte migration. (PubMed id 22065575)¹ Sun Z....Chen S. (2011)
GI^I^ subunits inhibit Epac-induced melanoma cell migra tion. (PubMed id 21679469)¹ Baljinnyam E....Iwatsubo K. (2011)
Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. (PubMed id 20133939)¹ Nagai Y....Itoh H. (2010)
Differential regulation of phospholipase C-beta2 acti vity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. (PubMed id 20007712)¹ Gutman O....Henis Y.I. (2010)
Scanning mutagenesis of the I-II loop of the Cav2.2 c alcium channel identifies residues Arginine 376 and Valine 416 as molecular det erminants of voltage dependent G protein inhibition. (PubMed id 20181083)¹ Tedford H.W....Zamponi G.W. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54331	HGNC: 4404	AceView: GNG2	Ensembl:ENSG00000186469	euGenes: HUgn54331
ECgene: GNG2	Kegg: 54331	H-InvDB: GNG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNG2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNG2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GNG2 gene:
Search GeneIP for patents involving GNG2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for GNG2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNG2
	OriGene Protein Over-expression Lysate for GNG2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GNG2		OriGene 3'-UTR Clone for GNG2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for GNG2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GNG2		OriGene Custom Protein Services for GNG2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNG2
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNG2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG2

	GenScript Custom Purified and Recombinant Proteins Services for GNG2		GenScript cDNA clones with any tag delivered in your preferred vector for GNG2
	GenScript Custom Assay Services for GNG2		GenScript Custom Superior Antibodies Services for GNG2
	GenScript Custom overexpressing Cell Line Services for GNG2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for GNG2
	Search Chromatin IP Primers for GNG2
	RT² qPCR Primer Assay in human, mouse, rat GNG2
	Search GNC Networks for GNG2
	SABiosciences PCR Arrays including human, mouse, rat GNG2

Tocris compounds for GNG2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GNG2 antibodies
	GNG2 proteins
	GNG2 lysates

	Search for Antibodies for GNG2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for GNG2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GNG2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG2

	SwitchGear 3'UTR luciferase reporter plasmids for GNG2
	SwitchGear Promoter luciferase reporter plasmids for GNG2

Search ThermoFisher Antibodies for GNG2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GNG2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GNG2 Gene

guanine nucleotide binding protein (G protein), gamma 2

Aliases
for GNG2 gene

Summaries
for GNG2 gene

Genomic Views
for GNG2 gene

Proteins
for GNG2 gene

Protein Domains /
Families
for GNG2 gene

Function
for GNG2 gene

Pathways & Interactions
for GNG2 gene

Drugs & Compounds
for GNG2 gene

Transcripts
for GNG2 gene

Expression
for GNG2 gene

Orthologs
for GNG2 gene

Paralogs
for GNG2 gene

Genomic Variants
for GNG2 gene

Disorders / Diseases
for GNG2 gene

Publications
for GNG2 gene

External Searches for GNG2 gene

Genome Databases showing GNG2 gene

Other Databases showing GNG2 gene

Specialized Databases showing GNG2 gene

Intellectual Property
for GNG2 gene

Products
for GNG2 gene

View Random Gene

Advanced Search

Export list of displayed genes

GNG2 Gene

guanine nucleotide binding protein (G protein), gamma 2

Aliasesfor GNG2 gene

Summariesfor GNG2 gene

Genomic Viewsfor GNG2 gene

Proteinsfor GNG2 gene

Protein Domains /Familiesfor GNG2 gene

Functionfor GNG2 gene

Pathways & Interactionsfor GNG2 gene

Drugs & Compoundsfor GNG2 gene

Transcriptsfor GNG2 gene

Expression for GNG2 gene

Orthologsfor GNG2 gene

Paralogsfor GNG2 gene

Genomic Variantsfor GNG2 gene

Disorders / Diseasesfor GNG2 gene

Publicationsfor GNG2 gene

External Searches for GNG2 gene

Genome Databases showing GNG2 gene

Other Databases showing GNG2 gene

Specialized Databases showing GNG2 gene

Intellectual Propertyfor GNG2 gene

Productsfor GNG2 gene

View Random Gene

Aliases
for GNG2 gene

Summaries
for GNG2 gene

Genomic Views
for GNG2 gene

Proteins
for GNG2 gene

Protein Domains /
Families
for GNG2 gene

Function
for GNG2 gene

Pathways & Interactions
for GNG2 gene

Drugs & Compounds
for GNG2 gene

Transcripts
for GNG2 gene

Expression
for GNG2 gene

Orthologs
for GNG2 gene

Paralogs
for GNG2 gene

Genomic Variants
for GNG2 gene

Disorders / Diseases
for GNG2 gene

Publications
for GNG2 gene

Intellectual Property
for GNG2 gene

Products
for GNG2 gene