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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNG2 Gene

protein-coding   GIFtS: 62
GCID: GC14P052327

Guanine Nucleotide Binding Protein (G Protein), Gamma 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 21 2
G Gamma-I2 3
Guanine Nucleotide Binding Protein Gamma 22
Guanine Nucleotide-Binding Protein G(I)/G(O) Gamma-2 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-22

External Ids:    HGNC: 44041   Entrez Gene: 543312   Ensembl: ENSG000001864697   OMIM: 6069815   UniProtKB: P597683   

Export aliases for GNG2 gene to outside databases

Previous GC identifers: GC14P049702 GC14M046231 GC14M050426 GC14P050303 GC14P051383 GC14P032487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNG2 Gene:
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in
signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different
signal molecules. (provided by RefSeq, Aug 2011)

GeneCards Summary for GNG2 Gene: 
GNG2 (guanine nucleotide binding protein (G protein), gamma 2) is a protein-coding gene. Diseases associated with GNG2 include familial hemiplegic migraine, and hemiplegic migraine, and among its related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction (By similarity)

summary for GNG2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GNG2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q21

GNG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P052327:  view genomic region     (about GC identifiers)

Start:
52,292,913 bp from pter      End:
52,446,060 bp from pter
Size:
153,148 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor  
Size: 71 amino acids; 7850 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1
and GNG2 interacts with PTH1R (via C-terminus)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for GNG2:
4KFM (3D)    
Secondary accessions: Q5JPE2 Q6P9A9

Explore the universe of human proteins at neXtProt for GNG2: NX_P59768

Explore proteomics data for GNG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59768

  • GNG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNG2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001230702.1  NP_001230703.1  NP_444292.1  

    ENSEMBL proteins: 
     ENSP00000451279   ENSP00000450904   ENSP00000450758   ENSP00000450586   ENSP00000334448  
     ENSP00000451102   ENSP00000451231   ENSP00000452014   ENSP00000451576   ENSP00000451536  
    Reactome Protein details: P59768
    Human Recombinant Protein Products for GNG2: 
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    Novus Biologicals GNG2 Protein
    Novus Biologicals GNG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex ISS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--

    GNG2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P59768

    ProtoNet protein and cluster: P59768

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768
    Similarity: Belongs to the G protein gamma family


    GNG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG2_HUMAN, P59768
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
         
    GNG2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GNG2:
     Decreased melanin production  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNG2 
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    hsa-miR-411* hsa-miR-3678-3p hsa-miR-379* hsa-miR-29a hsa-miR-1258 hsa-miR-105 hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidGNG2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNG2 About   (see all 73)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PI3Kgamma0.89
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.61
    Prostacyclin signalling through prostacyclin receptor0.77
    Glucagon-type ligand receptors0.58
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    3Thromboxane signalling through TP receptor
    Signal amplification0.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    ADP signalling through P2Y purinoceptor 10.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    5Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNG2 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/70 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG2 (see all 70)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNG2 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/13 BioSystems Pathways for GNG2 (see all 13)
        Myometrial Relaxation and Contraction Pathways
    Nicotine Activity on Dopaminergic Neurons
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway
    Plasma membrane estrogen receptor signaling


    5/48        Reactome Pathways for GNG2 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    2 PharmGKB Pathways for GNG2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for GNG2) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/383 Interacting proteins for GNG2 (P597682, 3 ENSP000003344484) via UniProtKB, MINT, STRING, and/or I2D (see all 383)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI1P630962, 3, ENSP000003430274MINT-8189440 I2D: score=1 STRING: ENSP00000343027
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    CACNA1HO951803, ENSP000003341984I2D: score=1 STRING: ENSP00000334198
    CHRM2P081723, ENSP000003199844I2D: score=1 STRING: ENSP00000319984
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway ISS--
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--

    GNG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for GNG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetother/unknown15175324 12657848 11961592 12826849 10913255

    Search CenterWatch for drugs/clinical trials and news about GNG2 / GBG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNG2 gene (3 alternative transcripts): 
    NM_001243773.1  NM_001243774.1  NM_053064.4  

    Unigene Clusters for GNG2:

    Guanine nucleotide binding protein (G protein), gamma 2
    Hs.187772  [show with all ESTs], Hs.709082  [show with all ESTs], Hs.723399  [show with all ESTs], Hs.741081  [show with all ESTs]
    Unigene Representative Sequences: NM_053064, BC041446, BX449893, DA315150
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553432 ENST00000556522 ENST00000557376 ENST00000553560 ENST00000554832
    ENST00000553299 ENST00000335281(uc010aoc.2 uc001wzi.3 uc021rte.1 uc001wzj.3)
    ENST00000557208 ENST00000555472 ENST00000556766 ENST00000554840 ENST00000554736
    ENST00000556752(uc001wzh.3 uc001wzk.3) ENST00000556471 ENST00000554875

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    hsa-miR-411* hsa-miR-3678-3p hsa-miR-379* hsa-miR-29a hsa-miR-1258 hsa-miR-105 hsa-miR-124 hsa-miR-298
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG2

    Additional mRNA sequence: AF493870.1 

    19 DOTS entries:

    DT.115864  DT.97767221  DT.95101239  DT.120792866  DT.100812746  DT.97773147  DT.100812745  DT.120792977 
    DT.95073569  DT.100640890  DT.120793040  DT.401432  DT.99932825  DT.100658238  DT.100812750  DT.120793046 
    DT.92355998  DT.95113831  DT.95206964 

    24/226 AceView cDNA sequences (see all 226):

    AA363566 BX109709 AU253254 BQ674586 AA977755 F01428 CR621932 AI932610 
    BI857090 AI879372 C01898 AI459446 AA287782 BM917190 AI610119 BQ718537 
    Z39525 AI818799 AA987952 AI468109 BQ950274 BQ890029 AI251778 BF978158 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GNG2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                    -     -     -                 -     -     -           -                                       
    SP2:                                      -           -           -     -     -           -                           
    SP3:                                      -           -     -     -     -     -           -                           
    SP4:                                      -     -     -     -     -     -     -           -                           
    SP5:                                      -           -     -     -     -     -     -     -     -                     


    ECgene alternative splicing isoforms for GNG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNG2 expression in normal human tissues (normalized intensities)      GNG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAATGTAT
    GNG2 Expression
    About this image


    GNG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             ganglion/cranial/facial VII   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             PERIPHERAL NERVOUS SYSTEM   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor EN7

    See GNG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNG2

    SOURCE GeneReport for Unigene clusters: Hs.187772 Hs.709082 Hs.723399 Hs.741081

    UniProtKB/Swiss-Prot: GBG2_HUMAN, P59768
    Tissue specificity: Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and
    brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG2 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng21 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 92.49(n)1
    100(a)1
      14 (11.17 cM)5
    147021  NM_001038637.11  NP_001033726.11 
     198725595 
    chicken
    (Gallus gallus)
    Aves GNG21 guanine nucleotide binding protein (G protein), gamma more 85.92(n)
    98.59(a)
      423581  NM_001097528.1  NP_001090997.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG26
    Guanine nucleotide-binding protein subunit gamma
    99(a)
    1 ↔ 1
    GL344470.1(37989-41014)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003322961 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit more 82.63(n)
    94.37(a)
      100332296  XM_002664141.2  XP_002664187.1 


    ENSEMBL Gene Tree for GNG2 (if available)
    TreeFam Gene Tree for GNG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNG2 gene
    GNG72  GNG102  GNG32  GNG82  GNG5P22  GNG52  GNG42  GNG122  
    11 SIMAP similar genes for GNG2 using alignment to 6 protein entries:     GBG2_HUMAN (see all proteins):
    GNG8    GNG4    GNG3    GNG7    DKFZp762E193    GNG12
    GNG5    GNG10    GNGT2    GNG11    GNGT1

    GNG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2477 SNPs in GNG2 are shown (see all 2477)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44685271,2
    C,F,A,H--52325131(+) GAACTG/AATTAA 3 -- us2k117Minor allele frequency- A:0.06NS EA NA WA CSA 795
    rs1126024561,2
    C--52325171(+) TATTGT/ATTGAA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs71475431,2
    C,F,H--52325213(+) TACCAA/GCCTAT 3 -- us2k110Minor allele frequency- G:0.38NS EA NA WA 768
    rs1493246451,2
    --52325290(+) AAAAAA/TTTACT 3 -- us2k10--------
    rs1446063281,2
    C--52325342(+) AATTAA/GCCATA 3 -- us2k10--------
    rs71483471,2
    C,F,H--52325397(+) ACTTGG/CCATCA 3 -- us2k120Minor allele frequency- C:0.39NA NS EA WA 2058
    rs1156144841,2
    --52325481(+) CATGTG/TGGTGG 3 -- us2k10--------
    rs101334311,2
    C,H--52325521(+) TTTCTA/GTCTGC 3 -- us2k14Minor allele frequency- G:0.00NS EA 416
    rs1882914421,2
    --52325541(+) AAAGCA/TAGTTG 3 -- us2k10--------
    rs1823013221,2
    --52325569(+) ATCAAC/TCCATT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNG2 (52292913 - 52446060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for GNG2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672618CNV Deletion23128226
    esv2748713CNV Deletion23290073
    esv1005848CNV Deletion20482838
    esv2748712CNV Deletion23290073
    esv2675664CNV Deletion23128226
    esv2571786CNV Deletion19546169
    esv2748714CNV Deletion23290073
    esv2000663CNV Deletion18987734
    esv2514556CNV Deletion19546169
    esv2670027CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606981    OMIM disorders: --

    13 diseases for GNG2:    About MalaCards
    familial hemiplegic migraine    hemiplegic migraine    migraine    agammaglobulinemia
    thrombosis    huntington's disease    acute lymphoblastic leukemia    lymphoblastic leukemia
    colorectal cancer    melanoma    leukemia    breast cancer
    neuronitis


    GNG2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNG2
    Human Genome Epidemiology (HuGE) Navigator: GNG2 (3 documents)

    Export disorders for GNG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNG2 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with GNG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. (PubMed id 10833460)1, 2, 3, 9 Modarressi M.H.... Wolfe J. (2000)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genome-wide association studies identify several new l oci associated with pigmentation traits and skin cancer risk in European America ns. (PubMed id 23548203)1 Zhang M....Han J. (2013)
    5. Functional analysis of GNG2 in human malignant melanom a cells. (PubMed id 23031273)1 Yajima I....Kato M. (2012)
    6. Topography of Gng2- and NetrinG2-expression suggests a n insular origin of the human claustrum. (PubMed id 22957104)1 Pirone A....Castagna M. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. The WD40 repeat protein WDR26 binds Gbg and promotes G bg-dependent signal transduction and leukocyte migration. (PubMed id 22065575)1 Sun Z....Chen S. (2011)
    9. GI^I^ subunits inhibit Epac-induced melanoma cell migra tion. (PubMed id 21679469)1 Baljinnyam E....Iwatsubo K. (2011)
    10. Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. (PubMed id 20133939)1 Nagai Y....Itoh H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54331 HGNC: 4404 AceView: GNG2 Ensembl:ENSG00000186469 euGenes: HUgn54331
    ECgene: GNG2 Kegg: 54331 H-InvDB: GNG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNG2 gene:
    Search GeneIP for patents involving GNG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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