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Aliases for GNG13 Gene

Aliases for GNG13 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 13 2 3
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-13 3
  • Guanine Nucleotide Binding Protein 13, Gamma 3
  • G Gamma Subunit, Clone:H2-35 3
  • G Gamma Subunit 2
  • Clone:H2-35 2
  • G(Gamma)13 3
  • H2-35 3

External Ids for GNG13 Gene

Previous GeneCards Identifiers for GNG13 Gene

  • GC16M000867
  • GC16M000788
  • GC16M000848
  • GC16M000770

Summaries for GNG13 Gene

Entrez Gene Summary for GNG13 Gene

  • Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

GeneCards Summary for GNG13 Gene

GNG13 (Guanine Nucleotide Binding Protein (G Protein), Gamma 13) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for GNG13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG13 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG13 Gene

Genomics for GNG13 Gene

Regulatory Elements for GNG13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG13 Gene

Start:
798,041 bp from pter
End:
800,733 bp from pter
Size:
2,693 bases
Orientation:
Minus strand

Genomic View for GNG13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG13 Gene

Proteins for GNG13 Gene

  • Protein details for GNG13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W3-GBG13_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Protein Accession:
    Q9P2W3
    Secondary Accessions:
    • B2R5C8
    • Q52LX0
    • Q9UJJ3

    Protein attributes for GNG13 Gene

    Size:
    67 amino acids
    Molecular mass:
    7949 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG13 Gene

Proteomics data for GNG13 Gene at MOPED

Post-translational modifications for GNG13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG13 Gene

Domains for GNG13 Gene

Protein Domains for GNG13 Gene

Suggested Antigen Peptide Sequences for GNG13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2W3

UniProtKB/Swiss-Prot:

GBG13_HUMAN :
  • Q9P2W3
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG13: view

No data available for Gene Families for GNG13 Gene

Function for GNG13 Gene

Molecular function for GNG13 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with GNG13: view
genes like me logo Genes that share phenotypes with GNG13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GNG13 Gene

Localization for GNG13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG13 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG13 Gene COMPARTMENTS Subcellular localization image for GNG13 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG13: view

Pathways for GNG13 Gene

SuperPathways for GNG13 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG13: view

Gene Ontology (GO) - Biological Process for GNG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with GNG13: view

Compounds for GNG13 Gene

(5) Tocris Compounds for GNG13 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG13 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG13: view

Transcripts for GNG13 Gene

mRNA/cDNA for GNG13 Gene

(15) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG13 Gene

Guanine nucleotide binding protein (G protein), gamma 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG13 Gene

No ASD Table

Relevant External Links for GNG13 Gene

GeneLoc Exon Structure for
GNG13
ECgene alternative splicing isoforms for
GNG13

Expression for GNG13 Gene

mRNA expression in normal human tissues for GNG13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG13 Gene

This gene is overexpressed in Brain - Cerebellum (22.5), Brain - Cerebellar Hemisphere (9.9), Brain - Frontal Cortex (BA9) (6.0), and Brain - Cortex (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNG13 Gene

SOURCE GeneReport for Unigene cluster for GNG13 Gene Hs.247888

genes like me logo Genes that share expressions with GNG13: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG13 Gene

Orthologs for GNG13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG13 35
  • 99.5 (n)
  • 100 (a)
GNG13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG13 35
  • 90.05 (n)
  • 94.03 (a)
GNG13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG13 35
  • 91.54 (n)
  • 95.52 (a)
GNG13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng13 35
  • 90.05 (n)
  • 95.52 (a)
Gng13 16
Gng13 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG13 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG13 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng13 35
  • 91.54 (n)
  • 95.52 (a)
chicken
(Gallus gallus)
Aves GNG13 35
  • 84.08 (n)
  • 82.09 (a)
GNG13 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gng13-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gng13 35
  • 81.09 (n)
  • 82.09 (a)
Str.2935 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3115 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14190 35
gng13a 36
  • 55 (a)
OneToMany
gng13b 35
  • 77.61 (n)
  • 74.63 (a)
gng13b 36
  • 75 (a)
OneToMany
Species with no ortholog for GNG13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG13 Gene

ENSEMBL:
Gene Tree for GNG13 (if available)
TreeFam:
Gene Tree for GNG13 (if available)

Paralogs for GNG13 Gene

Selected SIMAP similar genes for GNG13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG13: view

No data available for Paralogs for GNG13 Gene

Variants for GNG13 Gene

Sequence variations from dbSNP and Humsavar for GNG13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs735325 -- 799,894(+) CGTCC(C/T)CAAGG intron-variant
rs735326 -- 799,890(+) CCCCC(A/G)TCCCC intron-variant
rs2272900 -- 799,166(+) CCCCA(A/C)CCCCG intron-variant
rs2891064 -- 798,575(+) CGGGC(A/G)TGGGC utr-variant-3-prime
rs3817835 -- 799,423(+) GGCAG(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG13 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2498n71 CNV Loss 21882294
dgv2499n71 CNV Loss 21882294
dgv2500n71 CNV Loss 21882294
nsv517488 CNV Loss 19592680
nsv817712 CNV Loss 17921354
nsv904842 CNV Loss 21882294
nsv904843 CNV Loss 21882294
nsv904844 CNV Loss 21882294
nsv904845 CNV Gain 21882294
dgv2501n71 CNV Loss 21882294
dgv2502n71 CNV Loss 21882294
nsv482184 CNV Gain 20164927

Relevant External Links for GNG13 Gene

HapMap Linkage Disequilibrium report
GNG13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG13 Gene

Disorders for GNG13 Gene

Relevant External Links for GNG13

Human Genome Epidemiology (HuGE) Navigator
GNG13
genes like me logo Genes that share disorders with GNG13: view

No data available for UniProtKB/Swiss-Prot for GNG13 Gene

Publications for GNG13 Gene

  1. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PMID: 10570481) Huang L. … Margolskee R.F. (Nat. Neurosci. 1999) 2 3 4
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GNG13 Gene

Sources for GNG13 Gene

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