Aliases for GNG12 Gene
External Ids for GNG12 Gene
Previous GeneCards Identifiers for GNG12 Gene
GeneCards Summary for GNG12 Gene
GNG12 (G Protein Subunit Gamma 12) is a Protein Coding gene. Among its related pathways are GABAergic synapse and p75 NTR receptor-mediated signalling. GO annotations related to this gene include signal transducer activity and phosphate ion binding. An important paralog of this gene is GNG7.
UniProtKB/Swiss-Prot for GNG12 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.