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Aliases for GNG12 Gene

Aliases for GNG12 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 12 2 3

External Ids for GNG12 Gene

Previous GeneCards Identifiers for GNG12 Gene

  • GC01M067098
  • GC01M067524
  • GC01M067537
  • GC01M067879
  • GC01M067939
  • GC01M068167
  • GC01M066277

Summaries for GNG12 Gene

GeneCards Summary for GNG12 Gene

GNG12 (Guanine Nucleotide Binding Protein (G Protein), Gamma 12) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include signal transducer activity and phosphate ion binding. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG12 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG12 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG12 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG12 Gene

Genomics for GNG12 Gene

Regulatory Elements for GNG12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG12 Gene

Chromosome:
1
Start:
67,701,466 bp from pter
End:
67,833,779 bp from pter
Size:
132,314 bases
Orientation:
Minus strand

Genomic View for GNG12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG12 Gene

Proteins for GNG12 Gene

  • Protein details for GNG12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI6-GBG12_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Protein Accession:
    Q9UBI6
    Secondary Accessions:
    • Q69YP5
    • Q9BRV5

    Protein attributes for GNG12 Gene

    Size:
    72 amino acids
    Molecular mass:
    8006 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG12 Gene

Proteomics data for GNG12 Gene at MOPED

Post-translational modifications for GNG12 Gene

  • Ubiquitination at Lys 34 and Lys 64
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG12 Gene

Domains & Families for GNG12 Gene

Protein Domains for GNG12 Gene

Suggested Antigen Peptide Sequences for GNG12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBI6

UniProtKB/Swiss-Prot:

GBG12_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG12: view

No data available for Gene Families for GNG12 Gene

Function for GNG12 Gene

Molecular function for GNG12 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 21988832
GO:0030165 PDZ domain binding IDA 23209302
GO:0042301 phosphate ion binding IEA --
genes like me logo Genes that share ontologies with GNG12: view
genes like me logo Genes that share phenotypes with GNG12: view

Animal Model Products

miRNA for GNG12 Gene

miRTarBase miRNAs that target GNG12

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG12 Gene

Localization for GNG12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG12 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG12 Gene COMPARTMENTS Subcellular localization image for GNG12 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005884 actin filament IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG12: view

Pathways & Interactions for GNG12 Gene

genes like me logo Genes that share pathways with GNG12: view

SIGNOR curated interactions for GNG12 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007165 signal transduction TAS 10819326
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0021987 cerebral cortex development IEA --
genes like me logo Genes that share ontologies with GNG12: view

Drugs & Compounds for GNG12 Gene

(3) Drugs for GNG12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
mastoparan
72093-21-1
Mastoparan X
72093-22-2
SCH 202676 hydrobromide
265980-25-4
genes like me logo Genes that share compounds with GNG12: view

Transcripts for GNG12 Gene

mRNA/cDNA for GNG12 Gene

Unigene Clusters for GNG12 Gene

Guanine nucleotide binding protein (G protein), gamma 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for GNG12 Gene

GeneLoc Exon Structure for
GNG12
ECgene alternative splicing isoforms for
GNG12

Expression for GNG12 Gene

mRNA expression in normal human tissues for GNG12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG12 Gene

This gene is overexpressed in Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG12 Gene



SOURCE GeneReport for Unigene cluster for GNG12 Gene Hs.431101

genes like me logo Genes that share expression patterns with GNG12: view

Protein tissue co-expression partners for GNG12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNG12 Gene

Orthologs for GNG12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG12 35
  • 89.35 (n)
  • 94.44 (a)
GNG12 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG12 35
  • 91.2 (n)
  • 98.61 (a)
GNG12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng12 35
  • 86.57 (n)
  • 97.22 (a)
Gng12 16
Gng12 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNG12 35
  • 100 (n)
  • 100 (a)
GNG12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng12 35
  • 86.11 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia GNG12 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNG12 35
  • 78.24 (n)
  • 87.5 (a)
GNG12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng12 35
  • 79.63 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331581 35
  • 72.69 (n)
  • 77.78 (a)
GNG12 (2 of 2) 36
  • 78 (a)
OneToMany
gng12a 36
  • 72 (a)
OneToMany
Species with no ortholog for GNG12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG12 Gene

ENSEMBL:
Gene Tree for GNG12 (if available)
TreeFam:
Gene Tree for GNG12 (if available)

Paralogs for GNG12 Gene

Paralogs for GNG12 Gene

(10) SIMAP similar genes for GNG12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG12: view

Variants for GNG12 Gene

Sequence variations from dbSNP and Humsavar for GNG12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2198 -- 67,709,409(+) AGAGT(C/T)CCTGG intron-variant
rs7419 -- 67,701,808(-) ACTTG(A/G)TTACT utr-variant-3-prime
rs9549 -- 67,704,572(-) GATAG(G/T)CACCT utr-variant-3-prime
rs15471 -- 67,704,576(+) GCCTA(A/T)CCCTA utr-variant-3-prime
rs15472 -- 67,704,373(+) GGGGA(A/G)GGTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNG12 Gene

Variant ID Type Subtype PubMed ID
esv1336934 CNV Deletion 17803354
esv1542404 CNV Deletion 17803354
esv273176 CNV Insertion 20981092
nsv830104 CNV Gain 17160897

Variation tolerance for GNG12 Gene

Residual Variation Intolerance Score: 68.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG12 Gene

HapMap Linkage Disequilibrium report
GNG12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG12 Gene

Disorders for GNG12 Gene

Relevant External Links for GNG12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG12
genes like me logo Genes that share disorders with GNG12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG12 Gene

Publications for GNG12 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 2 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for GNG12 Gene

Sources for GNG12 Gene

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