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GNG12 Gene

protein-coding   GIFtS: 57
GCID: GC01M068167

Guanine Nucleotide Binding Protein (G Protein), Gamma 12

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 121 2
G-Protein Gamma-12 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-122

External Ids:    HGNC: 196631   Entrez Gene: 559702   Ensembl: ENSG000001723807   OMIM: 6154055   UniProtKB: Q9UBI63   

Export aliases for GNG12 gene to outside databases

Previous GC identifers: GC01M067098 GC01M067524 GC01M067537 GC01M067879 GC01M067939 GC01M066277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNG12 Gene:
GNG12 (guanine nucleotide binding protein (G protein), gamma 12) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG12_HUMAN, Q9UBI6
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG12 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG12 gene promoter:
         NF-1   AML1a   RelA   NF-kappaB   HNF-4alpha1   FOXL1   MZF-1   GATA-6   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNG12 promoter sequence
   Search Chromatin IP Primers for GNG12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

GNG12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068167:  view genomic region     (about GC identifiers)

Start:
68,167,149 bp from pter      End:
68,299,155 bp from pter
Size:
132,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GBG12_HUMAN, Q9UBI6 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor  
Size: 72 amino acids; 8006 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Secondary accessions: Q69YP5 Q9BRV5

Explore the universe of human proteins at neXtProt for GNG12: NX_Q9UBI6

Explore proteomics data for GNG12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys64
  • Modification sites at PhosphoSitePlus

  • See GNG12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061329.3  
    ENSEMBL proteins: 
     ENSP00000360021  
    Reactome Protein details: Q9UBI6

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    Search eBioscience for ELISAs for GNG12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBI6

    ProtoNet protein and cluster: Q9UBI6

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG12_HUMAN, Q9UBI6
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG12_HUMAN, Q9UBI6
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0030165PDZ domain binding IDA--
    GO:0042301phosphate ion binding IEA--
         
    Find genes that share ontologies with GNG12           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GNG12:
     Decreased G3BP1 protein expres 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNG12
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    miRNA
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    hsa-mir-423-5p (MIRT038094), hsa-mir-186-5p (MIRT045070)

    Block miRNA regulation of human, mouse, rat GNG12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG12 (see all 69):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-128 hsa-miR-759 hsa-miR-409-5p hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBG12_HUMAN, Q9UBI6: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GNG12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNG12 About   (see all 58)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    G-protein activation0.74
    G beta-gamma signalling through PI3Kgamma0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Signal amplification0.79
    Activation of Kainate Receptors upon glutamate binding0.68
    ADP signalling through P2Y purinoceptor 10.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3fMLP Pathway
    fMLP Pathway0.43
    Alpha-Adrenergic Signaling0.38
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    4EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    5Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57


    Find genes that share SuperPaths with GNG12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG12 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG12 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    4 BioSystems Pathways for GNG12
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Regulation of Actin Cytoskeleton

    Selected Reactome Pathways for GNG12 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor


    Selected Kegg Pathways  (Kegg details for GNG12) (see all 14):
        MAPK signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNG12
    Interactions:

        Search GeneGlobe Interaction Network for GNG12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG12 (Q9UBI62, 3 ENSP000003600214) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49158 I2D: score=2 
    CAPN1P073843, ENSP000002792474I2D: score=2 STRING: ENSP00000279247
    EIF4A2Q142403, ENSP000003263814I2D: score=1 STRING: ENSP00000326381
    GNB4Q9HAV03, ENSP000002325644I2D: score=1 STRING: ENSP00000232564
    STAM2O758863, ENSP000002639044I2D: score=1 STRING: ENSP00000263904
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007165signal transduction TAS10819326
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--
    GO:0021987cerebral cortex development IEA--

    Find genes that share ontologies with GNG12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNG12 gene: 
    NM_018841.5  

    Unigene Cluster for GNG12:

    Guanine nucleotide binding protein (G protein), gamma 12
    Hs.431101  [show with all ESTs]
    Unigene Representative Sequence: NM_018841
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370982(uc001dea.2) ENST00000494936
    miRNA
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    hsa-miR-140-5p hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-128 hsa-miR-759 hsa-miR-409-5p hsa-miR-4274
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      QuantiTect SYBR Green Assays in human, mouse, rat GNG12
      QuantiFast Probe-based Assays in human, mouse, rat GNG12

    Additional mRNA sequence: 

    AF119663.1 AF123766.1 AF365871.1 AF493879.1 AK055914.1 AK092014.1 AK223000.1 AK293101.1 
    AL049367.1 AL832431.1 BC005940.1 BC013090.1 

    12 DOTS entries:

    DT.452191  DT.100687887  DT.97822344  DT.102845559  DT.121433708  DT.121433724  DT.100881688  DT.95371205 
    DT.95371204  DT.121433558  DT.95123703  DT.95371206 

    Selected AceView cDNA sequences (see all 413):

    BM470903 AI581366 BM976426 BM014023 BU151184 CB159613 CB132729 CR605876 
    H99353 BU620098 CR593144 BQ212914 BM679222 CA449262 AI347458 BU177925 
    AF493879 AV706906 N42894 BU951886 CB988155 AI569359 BQ894081 BX486512 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNG12 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -     -                 -     -                                       
    SP2:        -     -           -     -     -                                       
    SP3:              -           -     -     -                                       
    SP4:                          -     -     -                                       
    SP5:                                      -                                       


    ECgene alternative splicing isoforms for GNG12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNG12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACAGATT
    GNG12 Expression
    About this image


    GNG12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    GNG12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431101
        Custom PCR Arrays for GNG12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GNG12 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng121 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 86.57(n)1
    97.22(a)1
      6 (30.68 cM)5
    147011  NM_025278.51  NP_079554.11 
     668963975 
    chicken
    (Gallus gallus)
    Aves GNG121 guanine nucleotide binding protein (G protein), gamma more 78.24(n)
    87.5(a)
      772239  XM_001234702.3  XP_001234703.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gng121 guanine nucleotide binding protein (G protein), gamma more 79.63(n)
    83.33(a)
      100124710  NM_001102695.1  NP_001096165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003315811 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit more 72.69(n)
    77.78(a)
      100331581  XM_005168745.1  XP_005168802.1 


    ENSEMBL Gene Tree for GNG12 (if available)
    TreeFam Gene Tree for GNG12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNG12 gene
    GNG22  GNG72  GNG102  GNG32  GNG82  GNG5P22  GNG52  GNG42  
    10 SIMAP similar genes for GNG12 using alignment to 1 protein entry:     GBG12_HUMAN:
    GNG7    GNG4    GNG8    GNG10    GNG5    GNG3
    GNG2    GNG11    GNGT1    GNGT2

    Find genes that share paralogs with GNG12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNG12 (see all 2516)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918272751,2
    --68166657(+) AGGATG/TGGAAA 1 -- int10--------
    rs1145819381,2
    C,F--68166689(+) CATTAC/TGTCAC 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1818911041,2
    --68166719(+) CTCCCC/TTGTTG 1 -- int10--------
    rs759506491,2
    C,F--68166741(+) GGCAAG/ACAGGA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs4743841,2
    C,F,A,H--68166748(-) CCTCCC/TATCCT 1 -- int117Minor allele frequency- T:0.34NS EA NA WA CSA 740
    rs120435511,2
    C,F,H--68166786(+) GCTTCC/TAGTCC 1 -- int112Minor allele frequency- T:0.40NS EA NA WA 780
    rs1444344111,2
    --68166834(+) TCCAAC/TGCATA 1 -- int10--------
    rs765734761,2
    C--68166845(+) CTGTT-/CTTCTC 1 -- int10--------
    rs1849383121,2
    --68166947(+) CACTCA/TGTGTT 1 -- int10--------
    rs1461461741,2
    C--68166964(+) AGTTAC/TAGCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNG12 (68167149 - 68299155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GNG12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1542404CNV Deletion17803354
    esv1336934CNV Deletion17803354
    esv273176CNV Insertion20981092
    nsv830104CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG12
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615405    OMIM disorders: --


    Find genes that share disorders with GNG12           About GenesLikeMe


    Export disorders for GNG12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNG12 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with GNG12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PubMed id 10819326)1, 2, 3 Hurowitz E.H....Shizuya H. (DNA Res. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. (PubMed id 11714923)1, 2 Cook L.A....Hildebrandt J.D. (Protein Sci. 2001)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. (PubMed id 24023390)2 Catherman A.D.... Kelleher N.L. (Mol. Cell. Proteomics 2013)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55970 HGNC: 19663 AceView: GNG12 Ensembl:ENSG00000172380 euGenes: HUgn55970
    ECgene: GNG12 Kegg: 55970 H-InvDB: GNG12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNG12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNG12 gene:
    Search GeneIP for patents involving GNG12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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