Aliases for GNG12 Gene
External Ids for GNG12 Gene
Previous GeneCards Identifiers for GNG12 Gene
GeneCards Summary for GNG12 Gene
GNG12 (G Protein Subunit Gamma 12) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include signal transducer activity and phosphate ion binding. An important paralog of this gene is GNG8.
UniProtKB/Swiss-Prot for GNG12 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.