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Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • G Protein Subunit Gamma 11 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNGT11 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 3

External Ids for GNG11 Gene

Previous GeneCards Identifiers for GNG11 Gene

  • GC07P092086
  • GC07P093149
  • GC07P093163
  • GC07P093195
  • GC07P093388
  • GC07P093551
  • GC07P088158

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

Regulatory Elements for GNG11 Gene

Enhancers for GNG11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F094059 1.3 FANTOM5 Ensembl ENCODE 11.4 +138.7 138725 2.2 MTA2 CBFB CEBPB JUNB GABPA EED IKZF1 TCF7 ETV6 CREM BET1 GNG11 LOC105375401 TFPI2 ENSG00000236938 ENSG00000236453
GH07F094055 1.3 FANTOM5 Ensembl ENCODE 11 +135.5 135537 2.8 JUN TEAD4 MAX BACH1 ZBTB40 ZNF316 SCRT2 FOS NFE2 MAFK BET1 GNG11 LOC105375401 TFPI2 ENSG00000236938 ENSG00000236453
GH07F094003 1.1 ENCODE 11.4 +82.5 82478 1.9 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 NFYC ZHX2 REST RPS3AP25 RPS27P17 GNG11 LOC105375403 BET1
GH07F094087 1.1 Ensembl ENCODE 10.7 +166.7 166702 1.6 PKNOX1 SIN3A BMI1 ZNF2 RAD21 ZNF366 ZNF143 DEK MIXL1 THAP11 GNG11 TFPI2 LOC105375401 ENSG00000236938 GC07P094145
GH07F094043 1 FANTOM5 Ensembl 10.8 +121.9 121902 0.8 JUND JUN BHLHE40 CEBPB FOS EP300 GNG11 BET1 ENSG00000236453 ENSG00000236938
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNG11 on UCSC Golden Path with GeneCards custom track

Promoters for GNG11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000630396 1201 4200 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 FOS REST SMARCB1

Genomic Location for GNG11 Gene

Chromosome:
7
Start:
93,921,699 bp from pter
End:
93,928,610 bp from pter
Size:
6,912 bases
Orientation:
Plus strand

Genomic View for GNG11 Gene

Genes around GNG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG11 Gene

Proteins for GNG11 Gene

  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61952-GBG11_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    P61952
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    Size:
    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

neXtProt entry for GNG11 Gene

Post-translational modifications for GNG11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains & Families for GNG11 Gene

Protein Domains for GNG11 Gene

Graphical View of Domain Structure for InterPro Entry

P61952

UniProtKB/Swiss-Prot:

GBG11_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG11: view

No data available for Gene Families for GNG11 Gene

Function for GNG11 Gene

Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG11: view
genes like me logo Genes that share phenotypes with GNG11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GNG11: view

Pathways & Interactions for GNG11 Gene

genes like me logo Genes that share pathways with GNG11: view

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7665596
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG11: view

No data available for SIGNOR curated interactions for GNG11 Gene

Drugs & Compounds for GNG11 Gene

(3) Drugs for GNG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

mRNA/cDNA for GNG11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG11 Gene

Guanine nucleotide binding protein (G protein), gamma 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
GNG11
ECgene alternative splicing isoforms for
GNG11

Expression for GNG11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG11 Gene

This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG11 Gene



NURSA nuclear receptor signaling pathways regulating expression of GNG11 Gene:

GNG11

SOURCE GeneReport for Unigene cluster for GNG11 Gene:

Hs.83381

mRNA Expression by UniProt/SwissProt for GNG11 Gene:

P61952-GBG11_HUMAN
Tissue specificity: Abundantly expressed in all tissues tested except for brain.
genes like me logo Genes that share expression patterns with GNG11: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for GNG11 Gene

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG11 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia GNG11 34 35 35
  • 91.78 (n)
mouse
(Mus musculus)
Mammalia Gng11 34 16 35
  • 91.78 (n)
rat
(Rattus norvegicus)
Mammalia Gng11 34
  • 91.78 (n)
dog
(Canis familiaris)
Mammalia GNG11 34 35
  • 91.32 (n)
chicken
(Gallus gallus)
Aves GNG11 34
  • 76.26 (n)
lizard
(Anolis carolinensis)
Reptilia GNG11 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12711 34
zebrafish
(Danio rerio)
Actinopterygii gngt1 35
  • 60 (a)
OneToMany
Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

ENSEMBL:
Gene Tree for GNG11 (if available)
TreeFam:
Gene Tree for GNG11 (if available)

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

(11) SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

Sequence variations from dbSNP and Humsavar for GNG11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10225791 -- 93,922,246(+) GGCTG(C/G/T)TCCGG intron-variant
rs10242728 -- 93,922,556(+) AGCGG(A/G)TAGCT intron-variant
rs10267504 -- 93,926,919(+) CTGCC(A/G)TGTAG intron-variant, downstream-variant-500B
rs10279807 -- 93,920,765(+) TTCAC(C/T)TGCCT intron-variant, upstream-variant-2KB
rs112016765 -- 93,922,387(+) CTGCC(A/G)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG11 Gene

Variant ID Type Subtype PubMed ID
nsv607849 CNV gain 21841781
nsv1023193 CNV gain 25217958
esv3614175 CNV loss 21293372

Variation tolerance for GNG11 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG11 Gene

Disorders for GNG11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
- elite association - COSMIC cancer census association via MalaCards
Search GNG11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNG11

Genetic Association Database (GAD)
GNG11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG11
genes like me logo Genes that share disorders with GNG11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. (PMID: 25241761) Chen T.C. … Huang C.Y. (J. Proteome Res. 2014) 3 64

Products for GNG11 Gene

Sources for GNG11 Gene

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