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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNG11 Gene

protein-coding   GIFtS: 56
GCID: GC07P093551

Guanine Nucleotide Binding Protein (G Protein), Gamma 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 111 2
G Protein Gamma-11 Subunit1 2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit1 2
GNGT112 3
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-112

External Ids:    HGNC: 44031   Entrez Gene: 27912   Ensembl: ENSG000001279207   OMIM: 6043905   UniProtKB: P619523   

Export aliases for GNG11 gene to outside databases

Previous GC identifers: GC07P092086 GC07P093149 GC07P093163 GC07P093195 GC07P093388 GC07P088158


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNG11 Gene:
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a
lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a
role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing.
Decreased expression of this gene is associated with splenic marginal zone lymphomas. (provided by RefSeq, Jul
2008)

GeneCards Summary for GNG11 Gene: 
GNG11 (guanine nucleotide binding protein (G protein), gamma 11) is a protein-coding gene. Diseases associated with GNG11 include splenic marginal zone lymphoma, and huntington's disease, and among its related super-pathways are Thromboxane signalling through TP receptor and Glucagon signaling in metabolic regulation. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG11 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNG11 gene promoter:
         Nkx3-1   HFH-3   STAT5B   Nkx3-1 v4   C/EBPbeta   Nkx3-1 v1   E4BP4   FOXI1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNG11 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNG11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q31-q32

GNG11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG11 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P093551:  view genomic region     (about GC identifiers)

Start:
93,551,011 bp from pter      End:
93,555,831 bp from pter
Size:
4,821 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 92,880,183-92,884,993     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor  
Size: 73 amino acids; 8481 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with
beta-2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: P50152

Explore the universe of human proteins at neXtProt for GNG11: NX_P61952

Explore proteomics data for GNG11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61952

  • GNG11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNG11 Protein Expression
    REFSEQ proteins: NP_004117.1  
    ENSEMBL proteins: 
     ENSP00000248564  
    Reactome Protein details: P61952
    Human Recombinant Protein Products for GNG11: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    GNG11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P61952

    ProtoNet protein and cluster: P61952

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
    Similarity: Belongs to the G protein gamma family


    GNG11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG11_HUMAN, P61952
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7665596
    GO:0004871signal transducer activity IEA--
         
    GNG11 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GNG11:
     Decreased viability  G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNG11 
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    hsa-miR-587
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNG11 About   (see all 53)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Thromboxane signalling through TP receptor
    ADP signalling through P2Y purinoceptor 10.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    Signal amplification0.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    3fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    Alpha-Adrenergic Signaling0.38
    4Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    5Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNG11 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG11 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNG11 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG11
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    5/40        Reactome Pathways for GNG11 (see all 40)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G alpha (z) signalling events
    G-protein activation
    Signal Transduction


    5/11         Kegg Pathways  (Kegg details for GNG11) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNG11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for GNG11 (P619522, 3 ENSP000002485644) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZHX1Q9UKY12, 3, ENSP000002978574MINT-63949 I2D: score=4 STRING: ENSP00000297857
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    AMOTL2Q9Y2J43, ENSP000002498834I2D: score=4 STRING: ENSP00000249883
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS7665596
    GO:0007165signal transduction TAS7665596
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0044281small molecule metabolic process TAS--

    GNG11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNG11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNG11 / GBG11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNG11 gene: 
    NM_004126.3  

    Unigene Cluster for GNG11:

    Guanine nucleotide binding protein (G protein), gamma 11
    Hs.83381  [show with all ESTs]
    Unigene Representative Sequence: BF971151
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248564(uc003und.3)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF493878.1 AK312037.1 BC009709.1 BT007141.1 U31384.1 

    4 DOTS entries:

    DT.100778597  DT.99953450  DT.454697  DT.95160871 

    24/120 AceView cDNA sequences (see all 120):

    CB997805 CR622777 CR603702 CR590486 AF493878 CR596301 AW161552 CR592688 
    BX110899 AI160703 CA396713 BX340171 AL551519 AI139572 AA150894 W57645 
    BM759770 BG255463 CA407850 CA391579 AA708447 CB992042 BG165259 BX474343 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNG11 expression in normal human tissues (normalized intensities)      GNG11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTTCTTT
    GNG11 Expression
    About this image


    GNG11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood endothelial colony-forming cells
     
     Heart (Cardiovascular System)
             Cardiac Myocytes   
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Liver (Hepatobiliary System)
             Human Hepatic Stellate Cells (HHSteC)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells

    See GNG11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNG11

    SOURCE GeneReport for Unigene cluster: Hs.83381

    UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
    Tissue specificity: Abundantly expressed in all tissues tested except for brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including GNG11: 
              Alzheimer's Disease in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG11 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng111 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 91.78(n)1
    100(a)1
      6 (1.81 cM)5
    660661  NM_025331.21  NP_079607.11 
     40039435 
    chicken
    (Gallus gallus)
    Aves GNG111 guanine nucleotide binding protein (G protein), gamma more 76.26(n)
    84.93(a)
      771999  XM_001234332.2  XP_001234333.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG116
    Guanine nucleotide-binding protein subunit gamma
    86(a)
    1 ↔ 1
    6(21957604-21969169)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.127112 Transcribed sequence with moderate similarity to protein more 75(n)    BX717759.1 


    ENSEMBL Gene Tree for GNG11 (if available)
    TreeFam Gene Tree for GNG11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNG11 gene
    GNGT12  GNGT22  
    12 SIMAP similar genes for GNG11 using alignment to 2 protein entries:     GBG11_HUMAN (see all proteins):
    GNGT1    GNGT2    DKFZp762E193    GNG12    GNG7    GNG3
    GNG2    GNG8    GNG10    GNG13    GNG4    GNG5

    GNG11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 SNPs in GNG11 are shown (see all 151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926510101,2
    --93549101(+) TAATAC/TGTCTC 1 -- us2k10--------
    rs1802451,2
    C,F,A,H--93549271(-) GCGCCG/CGCTAC 1 -- us2k17Minor allele frequency- C:0.36NA WA CSA 14
    rs1474325271,2
    --93549295(+) TCCTCC/GGGAGG 1 -- us2k10--------
    rs1802441,2
    C,F,A,H--93549363(-) AGTGAG/CTGGCA 1 -- us2k18Minor allele frequency- C:0.44NA WA CSA 16
    rs69739071,2
    C--93549395(+) gactcC/Tgtctc 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs582938401,2
    C--93549401(+) GTCTC-/AAAAAAA 1 -- us2k10--------
    rs2020082721,2
    --93549425(+) ACAAA-/ACAAAAC 1 -- us2k10--------
    rs119724651,2
    C,H--93549426(+) acaaaA/CaaaCA 1 -- us2k10--------
    rs1454942901,2
    --93549430(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs2019367061,2
    --93549430(+) AAAAA-/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNG11 (93551011 - 93555831 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GNG11: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG11
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604390    OMIM disorders: --

    6 diseases for GNG11:    About MalaCards
    splenic marginal zone lymphoma    huntington's disease    colorectal cancer    alzheimer's disease
    breast cancer    neuronitis


    GNG11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNG11

    Export disorders for GNG11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNG11 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with GNG11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (2013)
    5. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (2009)
    6. G-protein gamma subunit GNG11 strongly regulates cellular senescence. (PubMed id 17092487)1 Hossain M.N....Ayusawa D. (2006)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    10. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. (PubMed id 15914563)1 Ruiz-Ballesteros E....Piris M.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2791 HGNC: 4403 AceView: GNG11 Ensembl:ENSG00000127920 euGenes: HUgn2791
    ECgene: GNG11 Kegg: 2791 H-InvDB: GNG11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNG11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNG11 gene:
    Search GeneIP for patents involving GNG11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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