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GNG11 Gene

protein-coding   GIFtS: 55
GCID: GC07P093551

Guanine Nucleotide Binding Protein (G Protein), Gamma 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 111 2
G Protein Gamma-11 Subunit1 2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit1 2
GNGT112 3
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-112

External Ids:    HGNC: 44031   Entrez Gene: 27912   Ensembl: ENSG000001279207   OMIM: 6043905   UniProtKB: P619523   

Export aliases for GNG11 gene to outside databases

Previous GC identifers: GC07P092086 GC07P093149 GC07P093163 GC07P093195 GC07P093388 GC07P088158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNG11 Gene:
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a
lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a
role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing.
Decreased expression of this gene is associated with splenic marginal zone lymphomas. (provided by RefSeq, Jul
2008)

GeneCards Summary for GNG11 Gene:
GNG11 (guanine nucleotide binding protein (G protein), gamma 11) is a protein-coding gene. Diseases associated with GNG11 include splenic marginal zone lymphoma, and huntington's disease. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNG11 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG11 gene promoter:
         Nkx3-1   HFH-3   STAT5B   Nkx3-1 v4   C/EBPbeta   Nkx3-1 v1   E4BP4   FOXI1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNG11 promoter sequence
   Search Chromatin IP Primers for GNG11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q31-q32

GNG11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG11 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P093551:  view genomic region     (about GC identifiers)

Start:
93,551,011 bp from pter      End:
93,557,922 bp from pter
Size:
6,912 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 92,880,183-92,884,993     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor  
Size: 73 amino acids; 8481 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with
beta-2
Secondary accessions: P50152

Explore the universe of human proteins at neXtProt for GNG11: NX_P61952

Explore proteomics data for GNG11 at MOPED


See GNG11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004117.1  
ENSEMBL proteins: 
 ENSP00000248564  
Reactome Protein details: P61952

GNG11 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for GNG11

GNG11 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR001770 Gprotein-gamma
 IPR015898 G-protein_gamma-like_dom

Graphical View of Domain Structure for InterPro Entry P61952

ProtoNet protein and cluster: P61952

1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
Similarity: Belongs to the G protein gamma family


GNG11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GBG11_HUMAN, P61952
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity TAS7665596
GO:0004871signal transducer activity IEA--
     
GNG11 for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for GNG11:
 Decreased viability  G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNG11
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNG11

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNG11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNG11

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat GNG11 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate GNG11:
hsa-miR-587
SwitchGear 3'UTR luciferase reporter plasmidGNG11 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for GNG11
Predesigned siRNA for gene silencing in human, mouse, rat GNG11

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GNG11

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OriGene clones in human, mouse for GNG11 (see all 6)
OriGene ORF clones in mouse, rat for GNG11
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GenScript: all cDNA clones in your preferred vector: GNG11 (NM_004126)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG11

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GBG11_HUMAN, P61952: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol3
extracellular1
golgi apparatus1
mitochondrion1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005834heterotrimeric G-protein complex IEA--
GO:0005886plasma membrane TAS--

GNG11 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GNG11 About   (see all 53)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1ADP signalling through P2Y purinoceptor 12
G-protein beta-gamma signalling0.90
G-protein activation0.74
G beta-gamma signalling through PI3Kgamma0.90
Thrombin signalling through proteinase activated receptors (PARs)0.69
Signal amplification0.79
Activation of Kainate Receptors upon glutamate binding0.68
ADP signalling through P2Y purinoceptor 10.79
Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
2Regulation of Water Balance by Renal Aquaporins
Regulation of Water Balance by Renal Aquaporins0.85
Glucagon signaling in metabolic regulation0.70
Aquaporin-mediated transport0.85
Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
3fMLP Pathway
fMLP Pathway0.43
Alpha-Adrenergic Signaling0.38
Signal transduction Activation of PKC via G Protein coupled receptor0.42
Huntington's Disease Pathway0.30
4EphB-EphrinB Signaling
EphB-EphrinB Signaling0.58
Cytoskeleton remodeling Reverse signaling by ephrin B0.34
Ephrin-Eph Signaling0.58
5Ca-dependent events
Opioid Signalling0.54
Signal transduction Calcium signaling0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG11 (see all 47)
    Molecular Mechanisms of Cancer
Intracellular Calcium Signaling
CDK5 Pathway
JNK Pathway
ERK5 Signaling

Selected GeneGo (Thomson Reuters) Pathways for GNG11 (see all 34)
    Signal transduction cAMP signaling
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
G-protein signaling G-Protein alpha-i signaling cascades
Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
Signal transduction Activation of PKC via G-Protein coupled receptor

3 BioSystems Pathways for GNG11
    Myometrial Relaxation and Contraction Pathways
G Protein Signaling Pathways
Calcium Regulation in the Cardiac Cell

Selected Reactome Pathways for GNG11 (see all 20)
    G alpha (12/13) signalling events
G alpha (z) signalling events
G-protein activation
Ca2+ pathway
Thromboxane signalling through TP receptor


Selected Kegg Pathways  (Kegg details for GNG11) (see all 12):
    Ras signaling pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling


GNG11 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including GNG11: 
          Alzheimer's Disease in human mouse rat
          Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for GNG11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GNG11 (P619522, 3 ENSP000002485644) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
InteractantInteraction Details
GeneCardExternal ID(s)
ZHX1Q9UKY12, 3, ENSP000002978574MINT-63949 I2D: score=4 STRING: ENSP00000297857
GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
AMOTL2Q9Y2J43, ENSP000002498834I2D: score=4 STRING: ENSP00000249883
ADCY4ENSP000003121264STRING: ENSP00000312126
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006112energy reserve metabolic process TAS--
GO:0006184GTP catabolic process TAS7665596
GO:0007165signal transduction TAS7665596
GO:0007186G-protein coupled receptor signaling pathway IEA--
GO:0044281small molecule metabolic process TAS--

GNG11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for GNG11 available from Tocris Bioscience    About this table
CompoundAction CAS #
GalleinInhibitor of betagamma signaling[2103-64-2]
Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

3 HMDB Compounds for GNG11    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine monophosphate5'-GMP (see all 14)85-32-5--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GNG11 gene: 
NM_004126.3  

Unigene Cluster for GNG11:

Guanine nucleotide binding protein (G protein), gamma 11
Hs.83381  [show with all ESTs]
Unigene Representative Sequence: BF971151
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000248564(uc003und.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat GNG11 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate GNG11:
hsa-miR-587
SwitchGear 3'UTR luciferase reporter plasmidGNG11 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat GNG11
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GenScript: all cDNA clones in your preferred vector: GNG11 (NM_004126)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG11
Primer
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OriGene qPCR primer pairs and template standards for GNG11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNG11
  QuantiTect SYBR Green Assays in human, mouse, rat GNG11
  QuantiFast Probe-based Assays in human, mouse, rat GNG11

Additional mRNA sequence: 

AF493878.1 AK312037.1 BC009709.1 BT007141.1 U31384.1 

4 DOTS entries:

DT.100778597  DT.99953450  DT.454697  DT.95160871 

Selected AceView cDNA sequences (see all 120):

AF493878 CR596301 BX110899 CA396713 CR592688 AL551519 CR622777 CR603702 
AA150894 CB997805 AW161552 W57645 CR590486 AI139572 BX340171 AI160703 
BQ641318 BM840020 BG169034 BE905861 BX101191 BX474343 BF115554 AI203748 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GNG11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACACTTCTTT
GNG11 Expression
About this image


GNG11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Dermis (Integumentary System)    fully expand to see all 2 entries
         Zigzag Dermal Papilla Cells Dermal Papilla
 
 Endothelium (Cardiovascular System)
         Human umbilical vein endothelial cells (HUVEC)
 
 Uterus (Reproductive System)
 
 Lung (Respiratory System)
 
 Ovary (Reproductive System)
GNG11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GNG11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.83381

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
Tissue specificity: Abundantly expressed in all tissues tested except for brain

    Pathway & Disease-focused RT2 Profiler PCR Arrays including GNG11: 
          Alzheimer's Disease in human mouse rat
          Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for GNG11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNG11
QuantiTect SYBR Green Assays in human, mouse, rat GNG11
QuantiFast Probe-based Assays in human, mouse, rat GNG11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GNG11 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gng111 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 91.78(n)1
100(a)1
  6 (1.81 cM)5
660661  NM_025331.21  NP_079607.11 
 40039435 
chicken
(Gallus gallus)
Aves GNG111 guanine nucleotide binding protein (G protein), gamma more 76.26(n)
84.93(a)
  771999  NM_001278047.1  NP_001264976.1 
lizard
(Anolis carolinensis)
Reptilia GNG116
guanine nucleotide binding protein (G protein), ga...
86(a)
1 ↔ 1
6(21957604-21969169)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.127112 Transcribed sequence with moderate similarity to protein more 75(n)    BX717759.1 
zebrafish
(Danio rerio)
Actinopterygii gngt16
guanine nucleotide binding protein (G protein), ga...
60(a)
1 → many
19(41817160-41820094) ENSDARG00000035798


ENSEMBL Gene Tree for GNG11 (if available)
TreeFam Gene Tree for GNG11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for GNG11 gene
GNGT12  GNGT22  
11 SIMAP similar genes for GNG11 using alignment to 2 protein entries:     GBG11_HUMAN (see all proteins):
GNGT1    GNGT2    GNG12    GNG7    GNG3    GNG2
GNG8    GNG10    GNG13    GNG4    GNG5

GNG11 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GNG11 (see all 151)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1926510101,2
--93549101(+) TAATAC/TGTCTC 1 -- us2k10--------
rs1802451,2
C,F,A,H--93549271(-) GCGCCG/CGCTAC 1 -- us2k17Minor allele frequency- C:0.36NA WA CSA 14
rs1474325271,2
--93549295(+) TCCTCC/GGGAGG 1 -- us2k10--------
rs1802441,2
C,F,A,H--93549363(-) AGTGAG/CTGGCA 1 -- us2k18Minor allele frequency- C:0.44NA WA CSA 16
rs69739071,2
C--93549395(+) gactcC/Tgtctc 1 -- us2k12Minor allele frequency- T:0.00NA 4
rs582938401,2
C--93549401(+) GTCTC-/AAAAAAA 1 -- us2k10--------
rs2020082721,2
--93549425(+) ACAAA-/ACAAAAC 1 -- us2k10--------
rs119724651,2
C,H--93549426(+) acaaaA/CaaaCA 1 -- us2k10--------
rs1454942901,2
--93549430(+) AAAAAA/CAAAAA 1 -- us2k10--------
rs2019367061,2
--93549430(+) AAAAA-/CAAAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GNG11 (93551011 - 93557922 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for GNG11: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GNG11
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604390    OMIM disorders: --

8 diseases for GNG11:    
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splenic marginal zone lymphoma    huntington's disease    pertussis    colorectal cancer
alzheimer's disease    breast cancer    neuronitis    endotheliitis


GNG11 for disorders           About GeneDecksing

Genetic Association Database (GAD): GNG11

Export disorders for GNG11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GNG11 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with GNG11)
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  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (J. Biol. Chem. 1995)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  4. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
  5. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (Cell. Signal. 2009)
  6. G-protein gamma subunit GNG11 strongly regulates cellular senescence. (PubMed id 17092487)1 Hossain M.N....Ayusawa D. (Biochem. Biophys. Res. Commun. 2006)
  7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
  10. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. (PubMed id 15914563)1 Ruiz-Ballesteros E....Piris M.A. (Blood 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2791 HGNC: 4403 AceView: GNG11 Ensembl:ENSG00000127920 euGenes: HUgn2791
ECgene: GNG11 Kegg: 2791 H-InvDB: GNG11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GNG11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GNG11 gene:
Search GeneIP for patents involving GNG11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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