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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNG11 Gene

protein-coding   GIFtS: 57
GCID: GC07P093551

guanine nucleotide binding protein (G protein), gamma 11
 Explore 4 diseases affiliated with
GNG11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GNG11    

Aliases
for GNG11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 111 2
GNGT111 2 3
G Protein Gamma-11 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-112

External Ids:    HGNC: 44031   Entrez Gene: 27912   Ensembl: ENSG000001279207   OMIM: 6043905   UniProtKB: P619523   

Export aliases for GNG11 gene to outside databases

Previous GC identifers: GC07P092086 GC07P093149 GC07P093163 GC07P093195 GC07P093388 GC07P088158


Summaries
for GNG11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNG11:
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored,
cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this
transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of
this gene is associated with splenic marginal zone lymphomas. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
GDP by GTP, and for G protein-effector interaction

summary for GNG11:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG11


Genomic Views
for GNG11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNG11 gene promoter:
         Nkx3-1   HFH-3   STAT5B   Nkx3-1 v4   C/EBPbeta   Nkx3-1 v1   E4BP4   FOXI1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNG11 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNG11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q31-q32

GNG11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG11 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P093551:  view genomic region     (about GC identifiers)

Start:
 93,551,011 bp from pter      End:
 93,555,831 bp from pter
Size:
 4,821 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 92,880,183-92,884,993     

Proteins
for GNG11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor  
Size: 73 amino acids; 8481 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with
beta-2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: P50152

Explore the universe of human proteins at neXtProt for GNG11: NX_P61952

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61952

    • GNG11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004117.1  
    ENSEMBL proteins: 
     ENSP00000248564  
    Reactome Protein details: P61952
    Human Recombinant Protein Products: 
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    Novus Biologicals GNG11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--


    GNG11 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GNG11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNG11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P61952

    ProtoNet protein and cluster: P61952

    1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
    Similarity: Belongs to the G protein gamma family


    Function
    for GNG11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
    GDP by GTP, and for G protein-effector interaction

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNG11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GNG11:
    hsa-miR-587
    SwitchGear 3'UTR luciferase reporter plasmid: GNG11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNG11 (see all 7)
    OriGene shRNA RFP: GNG11
    OriGene siRNA: GNG11
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG11

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7665596
    GO:0004871signal transducer activity IEA--


    GNG11 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for GNG11:
     Decreased viability  G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for GNG11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/57 super-pathways (see all 57) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G beta:gamma signalling through PLC beta
    8/12 pathways (see all 12)
    		G beta:gamma signalling through PLC beta1.00
    		G beta:gamma signalling through PI3Kgamma0.61
    		Presynaptic function of Kainate receptors0.95
    		Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.55
    		Prostacyclin signalling through prostacyclin receptor0.77
    		G-protein activation0.55
    		G-protein beta:gamma signalling0.71
    		Glucagon-type ligand receptors0.52
    2Development Angiotensin activation of ERK
    8/9 pathways (see all 9)
    		Development Angiotensin activation of ERK1.00
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development_EDNRB signaling0.54
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    3Development_A3 receptor signaling
    		Development_A3 receptor signaling1.00
    		Development A1 receptor signaling0.65
    		Development A3 receptor signaling1.00
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		Development_A1 receptor signaling0.65
    		G-protein signaling G-Protein alpha-q signaling cascades0.53
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Development_Dopamine D2 receptor transactivation of EGFR
    		Development_Dopamine D2 receptor transactivation of EGFR1.00
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		Development Dopamine D2 receptor transactivation of EGFR1.00
    		Chemotaxis_CXCR4 signaling pathway0.48
    		Development_Alpha-2 adrenergic receptor activation of ERK0.66
    		Chemotaxis CXCR4 signaling pathway0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/31 EMD Millipore Pathways for GNG11 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG11 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNG11 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNG11 
        G Protein Signaling Pathways
    Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell

    5/40        Reactome Pathways for GNG11 (see all 40)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G alpha (z) signalling events
    G-protein activation
    Signal Transduction


    3         Kegg Pathways  (Kegg details for GNG11):
        Chemokine signaling pathway
    Glutamatergic synapse
    Cholinergic synapse


    GNG11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for GNG11 (P619522, 3 ENSP000002485644) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZHX1Q9UKY12, 3, ENSP000002978574MINT-63949 I2D: score=4 STRING: ENSP00000297857
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    AMOTL2Q9Y2J43, ENSP000002498834I2D: score=4 STRING: ENSP00000249883
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS7665596
    GO:0007165signal transduction TAS7665596
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0044281small molecule metabolic process TAS--


    GNG11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNG11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNG11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    GRK2iGRK2 inhibitory polypeptide. Gbetagamma antagonist[148505-03-7]

    3 HMDB Compounds for GNG11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about GNG11 / GBG11 

    Transcripts
    for GNG11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNG11 gene: 
    NM_004126.3  

    Unigene Cluster for GNG11:

    Guanine nucleotide binding protein (G protein), gamma 11
    Hs.83381  [show with all ESTs]
    Unigene Representative Sequence: BF971151
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248564(uc003und.3)

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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF493878.1 AK312037.1 BC009709.1 BT007141.1 U31384.1 

    4 DOTS entries:

    DT.100778597  DT.99953450  DT.454697  DT.95160871 

    24/120 AceView cDNA sequences (see all 120):

    AL551519 CR622777 BX110899 AI160703 CR592688 AF493878 AW161552 CR603702 
    CB997805 W57645 AA150894 CR596301 CA396713 AI139572 BX340171 CR590486 
    BU150354 BF971151 N42976 BI545418 AA626075 BX475492 W42431 CB991509 

    GeneLoc Exon Structure


    Expression
    for GNG11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNG11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACACTTCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GNG11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GNG11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNG11

    SOURCE GeneReport for Unigene cluster: Hs.83381

    UniProtKB/Swiss-Prot: GBG11_HUMAN, P61952
    Tissue specificity: Abundantly expressed in all tissues tested except for brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including GNG11: 
              Alzheimer's Disease in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for GNG11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GNG11 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNG111 guanine nucleotide binding protein (G protein), gamma more 76.26(n)
    84.93(a)    		   771999  XM_001234332.2  XP_001234333.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GNG116
    		 --
    		 86(a)
    		 1 ↔ 1
    		 6(21958290-21968074)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.127112 Transcribed sequence with moderate similarity to protein more 75(n)    BX717759.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gngt16
    		 guanine nucleotide binding protein (G protein), ga...
    		 62(a)
    		 1 → many
    		 19(41817160-41820094)


    ENSEMBL Gene Tree for GNG11 (if available)
    TreeFam Gene Tree for GNG11 (if available) 

    Paralogs
    for GNG11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNG11 gene
    GNGT12  GNGT22  
    12 SIMAP similar genes for GNG11 using alignment to 2 protein entries:     GBG11_HUMAN (see all proteins):
    GNGT1    GNGT2    DKFZp762E193    GNG12    GNG7    GNG3
    GNG2    GNG8    GNG10    GNG13    GNG4    GNG5

    GNG11 for paralogs           About GeneDecksing



    Genomic Variants
    for GNG11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 NCBI SNPs in GNG11 are shown (see all 130)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1926510101,2
    		--93549101(+) TAATAC/TGTCTC 1 -- us2k10--------
    rs1802451,2
    		C,F,A,H,--93549271(-) GCGCCG/CGCTAC 1 -- us2k17Minor allele frequency- C:0.36NA WA CSA 14
    rs1474325271,2
    		--93549295(+) TCCTCC/GGGAGG 1 -- us2k10--------
    rs1802441,2
    		C,F,A,H,--93549363(-) AGTGAG/CTGGCA 1 -- us2k18Minor allele frequency- C:0.44NA WA CSA 16
    rs69739071,2
    		C--93549395(+) gactcC/Tgtctc 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs582938401,2
    		C--93549401(+) GTCTC-/AAAAAAA 1 -- us2k10--------
    rs2020082721,2
    		--93549425(+) ACAAA-/ACAAAAC 1 -- us2k10--------
    rs119724651,2
    		C,H,--93549426(+) acaaaA/CaaaCA 1 -- us2k10--------
    rs1454942901,2
    		--93549430(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs2019367061,2
    		--93549430(+) AAAAA-/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNG11 (93551011 - 93555831 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GNG11
         1 CNV: 94701

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    Disorders / Diseases
    for GNG11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNG11 for disorders           About GeneDecksing

    OMIM gene information: 604390    OMIM disorders: --

    4 diseases for GNG11:    About MalaCards
    splenic marginal zone lymphoma    huntington's disease    colorectal cancer    breast cancer


    Export disorders for GNG11 gene to outside databases

    Publications
    for GNG11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNG11 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with GNG11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (2009)
    5. G-protein gamma subunit GNG11 strongly regulates cellular senescence. (PubMed id 17092487)1 Hossain M.N....Ayusawa D. (2006)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    9. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. (PubMed id 15914563)1 Ruiz-Ballesteros E....Piris M.A. (2005)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)

    External Searches for GNG11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing GNG11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2791 HGNC: 4403 AceView: GNG11 Ensembl:ENSG00000127920 euGenes: HUgn2791
    ECgene: GNG11 Kegg: 2791 H-InvDB: GNG11

    Other Databases showing GNG11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNG11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNG11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNG11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNG11 gene:
    Search GeneIP for patents involving GNG11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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