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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNG10 Gene

protein-coding   GIFtS: 49
GCID: GC09P114423

Guanine Nucleotide Binding Protein (G Protein), Gamma 1...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 101 2
Guanine Nucleotide Binding Protein 102
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-102
GNGT103

External Ids:    HGNC: 44021   Entrez Gene: 27902   Ensembl: ENSG000002426167   OMIM: 6043895   UniProtKB: P501513   

Export aliases for GNG10 gene to outside databases

Previous GC identifers: GC09P105192 GC09P106125 GC09P107851 GC09P109773 GC09P111473 GC09P113435 GC09P113437 GC09P113439 GC09P113441 GC09P113443 GC09P113463 GC09P084022


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GNG10 Gene: 
GNG10 (guanine nucleotide binding protein (G protein), gamma 10) is a protein-coding gene. Diseases associated with GNG10 include huntington's disease, and colorectal cancer, and among its related super-pathways are Thromboxane signalling through TP receptor and Glucagon signaling in metabolic regulation. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

summary for GNG10 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNG10 gene promoter:
         STAT1   STAT1beta   CUTL1   MIF-1   STAT1alpha   FOXJ2 (long isoform)   Chx10   Sox9   FOXJ2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GNG10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.3

GNG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P114423:  view genomic region     (about GC identifiers)

Start:
114,423,615 bp from pter      End:
114,432,526 bp from pter
Size:
8,912 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor  
Size: 68 amino acids; 7205 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q3B7K2 Q4VC27

Explore the universe of human proteins at neXtProt for GNG10: NX_P50151

Explore proteomics data for GNG10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50151

  • GNG10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNG10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017998.1  NP_001185593.1  

    ENSEMBL proteins: 
     ENSP00000363411  
    Reactome Protein details: P50151
    Human Recombinant Protein Products for GNG10: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    GNG10 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P50151

    ProtoNet protein and cluster: P50151

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
    Similarity: Belongs to the G protein gamma family


    GNG10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG10_HUMAN, P50151
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7665596
    GO:0004871signal transducer activity IEA--
         
    GNG10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNG10 
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    hsa-mir-124 (MIRT002606)

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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG10 (see all 14):
    hsa-miR-30c hsa-miR-34b* hsa-miR-526b hsa-miR-4255 hsa-miR-30d hsa-miR-551b* hsa-miR-124 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNG10 About   (see all 55)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Thromboxane signalling through TP receptor
    ADP signalling through P2Y purinoceptor 10.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    Signal amplification0.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    3fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    Alpha-Adrenergic Signaling0.38
    4Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    5Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNG10 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG10 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNG10 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    1 BioSystems Pathway for GNG10
        G Protein Signaling Pathways

    5/48        Reactome Pathways for GNG10 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels


    5/11         Kegg Pathways  (Kegg details for GNG10) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNG10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for GNG10 (P501513 ENSP000003634114) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=1 STRING: ENSP00000367872
    GNB2P628793, ENSP000003052604I2D: score=1 STRING: ENSP00000305260
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS7665596
    GO:0007165signal transduction TAS7665596
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--

    GNG10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNG10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNG10 / GBG10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNG10 gene (2 alternative transcripts): 
    NM_001017998.3  NM_001198664.1  

    Unigene Clusters for GNG10:

    Guanine nucleotide binding protein (G protein), gamma 10
    Hs.534196  [show with all ESTs], Hs.732002  [show with all ESTs]
    Unigene Representative Sequences: NR_037148, BF214144
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374293(uc004bfp.3 uc011lws.2)
    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate GNG10 (see all 14):
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    Additional mRNA sequence: AF493877.1 

    12 DOTS entries:

    DT.447210  DT.102825661  DT.97859257  DT.100782535  DT.100804852  DT.100801491  DT.102843169  DT.121161912 
    DT.100801483  DT.97766995  DT.100037643  DT.95324778 

    24/443 AceView cDNA sequences (see all 443):

    AI697851 AI133376 BQ423410 BQ435308 BQ029388 CR602806 CB049125 R81214 
    AI017495 AI628655 AI305148 AA282816 AI246376 W39716 CK429625 BU162225 
    D61321 CR618166 BM313189 CR599029 AW583559 CA437113 AW583350 BC015391 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNG10 expression in normal human tissues (normalized intensities)      GNG10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTAC
    GNG10 Expression
    About this image


    GNG10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Globus Pallidus
             Substantia Nigra   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

     -- (Endocrine System)
             Pituitary gland   

    See GNG10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNG10

    SOURCE GeneReport for Unigene clusters: Hs.534196 Hs.732002

    UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
    Tissue specificity: Abundantly and ubiquitously expressed

        SABiosciences Custom PCR Arrays for GNG10
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG10 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng101 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 89.71(n)1
    95.59(a)1
      4 (32.36 cM)5
    147001  NM_025277.31  NP_079553.11 
     590350885 
    chicken
    (Gallus gallus)
    Aves GNG101 guanine nucleotide binding protein (G protein), gamma more 81.86(n)
    89.71(a)
      769603  NM_001205005.1  NP_001191934.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG106
    Guanine nucleotide-binding protein subunit gamma
    90(a)
    1 ↔ 1
    GL343476.1(506086-513554)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687282 hypothetical protein MGC68728 84.62(n)    BC060422.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167062 Transcribed sequence with moderate similarity to protein more 72.35(n)    BI980613.1 


    ENSEMBL Gene Tree for GNG10 (if available)
    TreeFam Gene Tree for GNG10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNG10 gene
    GNG22  GNG72  GNG32  GNG82  GNG5P22  GNG52  GNG42  GNG122  
    11 SIMAP similar genes for GNG10 using alignment to 1 protein entry:     GBG10_HUMAN:
    GNG5    DKFZp762E193    GNG12    GNG7    GNG2    GNG3
    GNG8    GNG4    GNG11    GNGT1    GNGT2

    GNG10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GNG10
    PGOHUM00000238650 PGOHUM00000262096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNG10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893725CNV Loss21882294
    nsv893724CNV Gain21882294
    nsv825041CNV Gain20364138
    nsv466486CNV Gain19166990
    nsv893726CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604389    OMIM disorders: --

    5 diseases for GNG10:    About MalaCards
    huntington's disease    colorectal cancer    melanoma    breast cancer
    neuronitis


    GNG10 for disorders           About GeneDecksing


    Export disorders for GNG10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNG10 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with GNG10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Novel somatic mutations in heterotrimeric G proteins in melanoma. (PubMed id 20424519)1 CA!rdenas-Navia L.I....Samuels Y. (2010)
    5. Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (2009)
    6. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (2009)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (2007)
    9. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. (PubMed id 12782285)1 Rosskopf D....Siffert W. (2003)
    10. Glucagon and regulation of glucose metabolism. (PubMed id 12626323)1 Jiang G. and Zhang B.B. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2790 HGNC: 4402 AceView: GNG10 Ensembl:ENSG00000242616 euGenes: HUgn2790
    ECgene: GNG10 Kegg: 2790 H-InvDB: GNG10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNG10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNG10 gene:
    Search GeneIP for patents involving GNG10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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