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Aliases for GNG10 Gene

Aliases for GNG10 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 10 2 3
  • GNGT10 4

External Ids for GNG10 Gene

Previous GeneCards Identifiers for GNG10 Gene

  • GC09P105192
  • GC09P106125
  • GC09P107851
  • GC09P109773
  • GC09P111473
  • GC09P113435
  • GC09P113437
  • GC09P113439
  • GC09P113441
  • GC09P113443
  • GC09P113463
  • GC09P114423
  • GC09P084022

Summaries for GNG10 Gene

GeneCards Summary for GNG10 Gene

GNG10 (Guanine Nucleotide Binding Protein (G Protein), Gamma 10) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG10 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

Tocris Summary for GNG10 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG10 Gene

Genomics for GNG10 Gene

Regulatory Elements for GNG10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG10 Gene

Start:
111,661,335 bp from pter
End:
111,670,246 bp from pter
Size:
8,912 bases
Orientation:
Plus strand

Genomic View for GNG10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG10 Gene

Proteins for GNG10 Gene

  • Protein details for GNG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50151-GBG10_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
    Protein Accession:
    P50151
    Secondary Accessions:
    • Q3B7K2
    • Q4VC27

    Protein attributes for GNG10 Gene

    Size:
    68 amino acids
    Molecular mass:
    7205 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG10 Gene

Proteomics data for GNG10 Gene at MOPED

Post-translational modifications for GNG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG10 Gene

Domains for GNG10 Gene

Protein Domains for GNG10 Gene

Suggested Antigen Peptide Sequences for GNG10 Gene

Graphical View of Domain Structure for InterPro Entry

P50151

UniProtKB/Swiss-Prot:

GBG10_HUMAN :
  • P50151
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG10: view

No data available for Gene Families for GNG10 Gene

Function for GNG10 Gene

Molecular function for GNG10 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

Gene Ontology (GO) - Molecular Function for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GNG10: view

Animal Model Products

CRISPR Products

miRNA for GNG10 Gene

miRTarBase miRNAs that target GNG10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNG10 Gene

Localization for GNG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG10 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG10 Gene COMPARTMENTS Subcellular localization image for GNG10 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GNG10: view

Pathways for GNG10 Gene

SuperPathways for GNG10 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG10: view

Gene Ontology (GO) - Biological Process for GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 7665596
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GNG10: view

Compounds for GNG10 Gene

(5) Tocris Compounds for GNG10 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG10 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG10: view

Transcripts for GNG10 Gene

mRNA/cDNA for GNG10 Gene

Unigene Clusters for GNG10 Gene

Guanine nucleotide binding protein (G protein), gamma 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG10 Gene

No ASD Table

Relevant External Links for GNG10 Gene

GeneLoc Exon Structure for
GNG10
ECgene alternative splicing isoforms for
GNG10

Expression for GNG10 Gene

mRNA expression in normal human tissues for GNG10 Gene

mRNA differential expression in normal tissues according to GTEx for GNG10 Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNG10 Gene

SOURCE GeneReport for Unigene cluster for GNG10 Gene Hs.534196

mRNA Expression by UniProt/SwissProt for GNG10 Gene

P50151-GBG10_HUMAN
Tissue specificity: Abundantly and ubiquitously expressed
genes like me logo Genes that share expressions with GNG10: view

In Situ Assay Products

Orthologs for GNG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG10 36
  • 100 (a)
OneToOne
LOC100611518 35
  • 99.49 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia GNG10 35
  • 89.71 (n)
  • 98.53 (a)
GNG10 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG10 35
  • 92.65 (n)
  • 95.59 (a)
GNG10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng10 35
  • 89.71 (n)
  • 95.59 (a)
Gng10 16
Gng10 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG10 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng10 35
  • 90.69 (n)
  • 95.59 (a)
chicken
(Gallus gallus)
Aves GNG10 35
  • 81.86 (n)
  • 89.71 (a)
GNG10 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNG10 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68728 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gng10 35
  • 76.96 (n)
  • 85.29 (a)
Str.17134 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16706 35
gng10 35
  • 71.08 (n)
  • 76.47 (a)
si:ch211-286b5.5 36
  • 47 (a)
ManyToMany
Species with no ortholog for GNG10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG10 Gene

ENSEMBL:
Gene Tree for GNG10 (if available)
TreeFam:
Gene Tree for GNG10 (if available)

Paralogs for GNG10 Gene

Paralogs for GNG10 Gene

Selected SIMAP similar genes for GNG10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GNG10 Gene

genes like me logo Genes that share paralogs with GNG10: view

Variants for GNG10 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNG10 Gene

Variant ID Type Subtype PubMed ID
nsv893724 CNV Gain 21882294
nsv825041 CNV Gain 20364138
nsv893725 CNV Loss 21882294
nsv893726 CNV Gain 21882294
nsv466486 CNV Gain 19166990

Relevant External Links for GNG10 Gene

HapMap Linkage Disequilibrium report
GNG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GNG10 Gene

Disorders for GNG10 Gene

No disorders were found for GNG10 Gene.

No data available for UniProtKB/Swiss-Prot for GNG10 Gene

Publications for GNG10 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PMID: 17185339) Fowler C.E. … Slesinger P.A. (J. Physiol. (Lond.) 2007) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for GNG10 Gene

Sources for GNG10 Gene

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