Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GNG10 Gene

protein-coding   GIFtS: 49
GCID: GC09P114423

Guanine Nucleotide Binding Protein (G Protein), Gamma 1...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Guanine Nucleotide Binding Protein (G Protein), Gamma 101 2
Guanine Nucleotide Binding Protein 102
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-102
GNGT103

External Ids:    HGNC: 44021   Entrez Gene: 27902   Ensembl: ENSG000002426167   OMIM: 6043895   UniProtKB: P501513   

Export aliases for GNG10 gene to outside databases

Previous GC identifers: GC09P105192 GC09P106125 GC09P107851 GC09P109773 GC09P111473 GC09P113435 GC09P113437 GC09P113439 GC09P113441 GC09P113443 GC09P113463 GC09P084022


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GNG10 Gene:
GNG10 (guanine nucleotide binding protein (G protein), gamma 10) is a protein-coding gene. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

summary for GNG10 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNG10 gene promoter:
         STAT1   STAT1beta   CUTL1   MIF-1   STAT1alpha   FOXJ2 (long isoform)   Chx10   Sox9   FOXJ2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GNG10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.3

GNG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNG10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P114423:  view genomic region     (about GC identifiers)

Start:
114,423,615 bp from pter      End:
114,432,526 bp from pter
Size:
8,912 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor  
Size: 68 amino acids; 7205 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Secondary accessions: Q3B7K2 Q4VC27

Explore the universe of human proteins at neXtProt for GNG10: NX_P50151

Explore proteomics data for GNG10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNG10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017998.1  NP_001185593.1  

    ENSEMBL proteins: 
     ENSP00000363411  
    Reactome Protein details: P50151

    GNG10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GNG10
    OriGene Protein Over-expression Lysate for GNG10
    OriGene MassSpec for GNG10
    OriGene Custom Protein Services for GNG10
    GenScript Custom Purified and Recombinant Proteins Services for GNG10
    Novus Biologicals GNG10 Protein
    Novus Biologicals GNG10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNG10 

     
    antibodies-online proteins for GNG10 (2 products) 

     
    antibodies-online peptides for GNG10

    GNG10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GNG10
    Search for Antibodies for GNG10 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GNG10
    Search LSBio for Antibodies for GNG10
    Search antibodies-online for antibodies for GNG10 

    GNG10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GNG10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNG10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNG10 
    antibodies-online kits for GNG10 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001770 Gprotein-gamma
     IPR015898 G-protein_gamma-like_dom

    Graphical View of Domain Structure for InterPro Entry P50151

    ProtoNet protein and cluster: P50151

    1 Blocks protein domain: IPB001770 Gamma G-protein (transducin) signature

    UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
    Similarity: Belongs to the G protein gamma family


    Find genes that share domains with GNG10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBG10_HUMAN, P50151
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7665596
    GO:0004871signal transducer activity IEA--
         
    Find genes that share ontologies with GNG10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNG10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNG10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNG10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNG10

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNG10:
    hsa-mir-1301-3p (MIRT035960), hsa-mir-124-3p (MIRT002606)

    Block miRNA regulation of human, mouse, rat GNG10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG10 (see all 14):
    hsa-miR-30c hsa-miR-34b* hsa-miR-526b hsa-miR-4255 hsa-miR-30d hsa-miR-551b* hsa-miR-124 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNG10
    Predesigned siRNA for gene silencing in human, mouse, rat GNG10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNG10

    Clone
    Products:
         
    OriGene clones in human, mouse for GNG10 (see all 6)
    OriGene ORF clones in mouse, rat for GNG10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNG10 (NM_001017998)
    Sino Biological Human cDNA Clone for GNG10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNG10
    Browse ESI BIO Cell Lines and PureStem Progenitors for GNG10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GBG10_HUMAN, P50151: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with GNG10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GNG10 About   (see all 55)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    G-protein activation0.74
    G beta-gamma signalling through PI3Kgamma0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Signal amplification0.79
    Activation of Kainate Receptors upon glutamate binding0.68
    ADP signalling through P2Y purinoceptor 10.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3fMLP Pathway
    fMLP Pathway0.43
    Alpha-Adrenergic Signaling0.38
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    4EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    5Ca-dependent events
    Opioid Signalling0.54
    Signal transduction Calcium signaling0.35


    Find genes that share SuperPaths with GNG10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNG10 (see all 47)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNG10 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    1 BioSystems Pathway for GNG10
        G Protein Signaling Pathways


    Selected Reactome Pathways for GNG10 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor


    Selected Kegg Pathways  (Kegg details for GNG10) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNG10
    Interactions:

        Search GeneGlobe Interaction Network for GNG10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNG10 (P501513 ENSP000003634114) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=1 STRING: ENSP00000367872
    GNB2P628793, ENSP000003052604I2D: score=1 STRING: ENSP00000305260
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS7665596
    GO:0007165signal transduction TAS7665596
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--

    Find genes that share ontologies with GNG10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNG10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNG10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GNG10 gene (2 alternative transcripts): 
    NM_001017998.3  NM_001198664.1  

    Unigene Cluster for GNG10:

    Guanine nucleotide binding protein (G protein), gamma 10
    Hs.534196  [show with all ESTs]
    Unigene Representative Sequence: NR_037148
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374293(uc004bfp.3 uc011lws.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GNG10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNG10 (see all 14):
    hsa-miR-30c hsa-miR-34b* hsa-miR-526b hsa-miR-4255 hsa-miR-30d hsa-miR-551b* hsa-miR-124 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GNG10
    Predesigned siRNA for gene silencing in human, mouse, rat GNG10
    Clone
    Products:
         
    OriGene clones in human, mouse for GNG10 (see all 6)
    OriGene ORF clones in mouse, rat for GNG10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNG10 (NM_001017998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNG10
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat GNG10
      Search QuantiTect SYBR Green Assays in human, mouse, rat GNG10
      QuantiFast Probe-based Assays in human, mouse, rat GNG10

    Additional mRNA sequence: 

    AF447177.1 AK095452.1 BC010384.1 BC015206.2 BC016319.1 BC048318.1 BC072671.1 BC107574.1 
    NR_037148.1 U31383.1 

    12 DOTS entries:

    DT.447210  DT.102825661  DT.97859257  DT.100782535  DT.100804852  DT.100801491  DT.102843169  DT.121161912 
    DT.100801483  DT.97766995  DT.100037643  DT.95324778 

    Selected AceView cDNA sequences (see all 443):

    BM314286 BQ009326 AI370774 BM272031 AK095452 BM855348 AA857327 BU569052 
    BC048318 AW440276 D61321 CR618166 BM313189 CR599029 AW583559 CA437113 
    AW583350 BC015391 CR619882 AA601167 Z40139 AI680349 BG656444 NM_004125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GNG10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTAC
    GNG10 Expression
    About this image


    GNG10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Globus Pallidus
             Substantia Nigra   
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    GNG10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNG10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534196

    UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151
    Tissue specificity: Abundantly and ubiquitously expressed

        Custom PCR Arrays for GNG10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNG10
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat GNG10
    Search QuantiTect SYBR Green Assays in human, mouse, rat GNG10
    QuantiFast Probe-based Assays in human, mouse, rat GNG10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GNG10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gng101 , 5 guanine nucleotide binding protein (G protein), gamma more1, 5 89.71(n)1
    95.59(a)1
      4 (32.36 cM)5
    147001  NM_025277.31  NP_079553.11 
     590350885 
    chicken
    (Gallus gallus)
    Aves GNG101 guanine nucleotide binding protein (G protein), gamma more 81.86(n)
    89.71(a)
      769603  NM_001205005.1  NP_001191934.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNG106
    guanine nucleotide binding protein (G protein), ga...
    90(a)
    1 ↔ 1
    GL343476.1(506086-513554)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687282 hypothetical protein MGC68728 84.62(n)    BC060422.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167062 Transcribed sequence with moderate similarity to protein more 72.35(n)    BI980613.1 


    ENSEMBL Gene Tree for GNG10 (if available)
    TreeFam Gene Tree for GNG10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GNG10 gene
    GNG22  GNG72  GNG32  GNG82  GNG5P22  GNG52  GNG42  GNG122  
    10 SIMAP similar genes for GNG10 using alignment to 1 protein entry:     GBG10_HUMAN:
    GNG5    GNG12    GNG7    GNG2    GNG3    GNG8
    GNG4    GNG11    GNGT1    GNGT2

    Find genes that share paralogs with GNG10           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GNG10
    PGOHUM00000238650 PGOHUM00000262096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNG10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893725CNV Loss21882294
    nsv893724CNV Gain21882294
    nsv825041CNV Gain20364138
    nsv466486CNV Gain19166990
    nsv893726CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNG10
    DNA2.0 Custom Variant and Variant Library Synthesis for GNG10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604389    OMIM disorders: --


    Find genes that share disorders with GNG10           About GenesLikeMe


    Export disorders for GNG10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GNG10 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with GNG10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (J. Biol. Chem. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Novel somatic mutations in heterotrimeric G proteins in melanoma. (PubMed id 20424519)1 CA!rdenas-Navia L.I....Samuels Y. (amp 2010)
    6. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    7. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (Cell. Signal. 2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (J. Physiol. (Lond.) 2007)
    10. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. (PubMed id 12782285)1 Rosskopf D....Siffert W. (FEBS Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2790 HGNC: 4402 AceView: GNG10 Ensembl:ENSG00000242616 euGenes: HUgn2790
    ECgene: GNG10 Kegg: 2790 H-InvDB: GNG10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GNG10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GNG10 gene:
    Search GeneIP for patents involving GNG10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GNG10  
     OriGene qPCR primer pairs and template standards for GNG10   OriGene Protein Over-expression Lysate for GNG10  
     OriGene MassSpec for GNG10   OriGene clones in human, mouse for GNG10  
     Browse OriGene qSTAR qPCR primer pairs   OriGene Purified Protein for GNG10  
     OriGene ORF clones in mouse, rat for GNG10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNG10   OriGene Custom Protein Services for GNG10  

     
     
     Block miRNA regulation of human, mouse, rat GNG10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GNG10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNG10 Predesigned siRNA for gene silencing in human, mouse, rat GNG10
     QuantiFast Probe-based Assays in human, mouse, rat GNG10 Search QuantiTect SYBR Green Assays in human, mouse, rat GNG10
     Custom PCR Arrays for GNG10 Search Chromatin IP Primers for GNG10
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat GNG10 Search GeneGlobe Interaction Network for GNG10
     Regulatory tfbs in GNG10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GNG10 GenScript cDNA clones with any tag delivered in your preferred vector for GNG10
     GenScript Custom Assay Services for GNG10 GenScript Custom overexpressing Cell Line Services for GNG10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GNG10
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GNG10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GNG10 proteins
     GNG10 lysates
     Search for Antibodies for GNG10 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GNG10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GNG10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GNG10
     Browse SwitchGear Promoter luciferase reporter plasmids for GNG10
     Search ThermoFisher Antibodies for GNG10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNG10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNG10
     Search LSBio for Antibodies for GNG10
     Browse compounds at ApexBio
     Search Addgene for plasmids for GNG10
      Search eBioscience for proteins for GNG10
      Search eBioscience for elisas for GNG10
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
      Search antibodies-online for antibodies for GNG10
     antibodies-online kits for GNG10 (2 products)
     antibodies-online peptides for GNG10
     antibodies-online proteins for GNG10 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNG10 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4