GNG10 Gene
protein-coding GIFtS: 51
GCID: GC09P114423
|
|
guanine nucleotide binding protein (G protein), gamma 1...
| |
Aliases
for GNG10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Guanine Nucleotide Binding Protein (G Protein), Gamma 101 2 | | Guanine Nucleotide Binding Protein 102 | | Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-102 | | GNGT103 |
Export aliases for GNG10 gene to outside databasesPrevious GC identifers: GC09P105192 GC09P106125 GC09P107851 GC09P109773 GC09P111473 GC09P113435 GC09P113437 GC09P113439 GC09P113441 GC09P113443 GC09P113463 GC09P084022 |
Summaries
for GNG10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3
 summary
for GNG10: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.
|
Genomic Views
for GNG10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNG10 gene promoter:
STAT1 STAT1beta CUTL1 MIF-1 STAT1alpha FOXJ2 (long isoform) Chx10 Sox9 FOXJ2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNG10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNG10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31.3GNG10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P114423: view genomic region
(about GC identifiers)
Start:
|
114,423,615 bp from pter |
End:
|
114,432,526 bp from pter |
Size:
|
8,912 bases |
Orientation:
|
plus strand |
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Proteins
for GNG10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor Size: 68 amino acids; 7205 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q3B7K2 Q4VC27Explore the universe of human proteins at neXtProt for GNG10: NX_P50151
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P50151
GNG10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001017998.1 NP_001185593.1
ENSEMBL proteins: ENSP00000363411 Reactome Protein details: P50151
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005834 | heterotrimeric G-protein complex |
IEA | -- | | GO:0005886 | plasma membrane |
TAS | -- |
GNG10 for ontologies About GeneDecksing
GNG10 Antibody Products:
Assay Products for GNG10: |
Protein
Domains /
Families
for GNG10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNG10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P50151ProtoNet protein and cluster: P50151 1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Similarity: Belongs to the G protein gamma family |
Function
for GNG10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GNG10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
GNG10 for ontologies About GeneDecksing
|
Pathways & Interactions
for GNG10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G beta:gamma signalling through PLC beta | | | 2 | Development Angiotensin activation of ERK | | | 3 | Development_A3 receptor signaling | | | 4 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 5 | Development_Dopamine D2 receptor transactivation of EGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/31 EMD Millipore Pathways for GNG10 (see all 31)
5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNG10 (see all 47)
5/34  GeneGo (Thomson Reuters) Pathways for GNG10 (see all 34)
1  BioSystems Pathway for GNG10
5/48 
Reactome Pathways for GNG10 (see all 48)
3 
Kegg Pathways (Kegg details for GNG10):
GNG10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for GNG10 (P501513 ENSP000003634114) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
GNG10 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNG10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for GNG10 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Gallein | Inhibitor of betagamma signaling | [2103-64-2] | | GRK2i | GRK2 inhibitory polypeptide. Gbetagamma antagonist | [148505-03-7] |
3 HMDB Compounds for GNG10 About this table
Search CenterWatch for drugs/clinical trials and news about GNG10 / GBG10
|
Transcripts
for GNG10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GNG10 gene (2 alternative transcripts): NM_001017998.3 NM_001198664.1 Unigene Clusters for GNG10: Guanine nucleotide binding protein (G protein), gamma 10 Hs.534196 [show with all ESTs], Hs.732002 [show with all ESTs]Unigene Representative Sequences: NR_037148, BF2141441 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000374293(uc004bfp.3 uc011lws.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNG10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNG10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GNG10 (NM_001017998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNG10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10 |
Additional cDNA sequence: AF493877.1 12 DOTS entries: DT.447210 DT.102825661 DT.97859257 DT.100782535 DT.100804852 DT.100801491 DT.102843169 DT.121161912 DT.100801483 DT.97766995 DT.100037643 DT.95324778 24/443 AceView cDNA sequences (see all 443): BE468014 AI073604 BQ009326 AW583559 CB049125 BM313189 CR618166 BU070845 R81214 AI628655 AI680349 AI246376 AW583350 AA811724 BQ423410 BU162225 CR619882 BG656444 AA609936 AA601167 BC015391 W39716 AW629006 BQ435308
GeneLoc Exon Structure
|
Expression
for GNG10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GNG10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATATTAC
About this image
See GNG10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNG10
SOURCE GeneReport for Unigene clusters: Hs.534196 Hs.732002
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Tissue specificity: Abundantly and ubiquitously expressed
SABiosciences Custom PCR Arrays for GNG10
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GNG10 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNG10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNG10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10 |
Orthologs
for GNG10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GNG10 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GNG101 |
guanine nucleotide binding protein (G protein), gamma more |
81.86(n)
89.71(a) |
|
769603 NM_001205005.1 NP_001191934.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GNG106 |
-- |
90(a) |
1 ↔ 1 |
GL343476.1(506086-513554) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC687282 |
hypothetical protein MGC68728 |
84.62(n) |
|
BC060422.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.167062 |
Transcribed sequence with moderate similarity to protein more |
72.35(n) |
|
BI980613.1 |
ENSEMBL Gene Tree for GNG10 (if available)
TreeFam Gene Tree for GNG10 (if available) |
Paralogs
for GNG10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GNG10 gene
- GNG22 GNG72 GNG32 GNG82 GNG5P22 GNG52 GNG42 GNG122
11 SIMAP similar genes for GNG10 using alignment to 1 protein entry: GBG10_HUMAN:GNG5 DKFZp762E193 GNG12 GNG7 GNG2 GNG3
GNG8 GNG4 GNG11 GNGT1 GNGT2
GNG10 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for GNG10
PGOHUM00000238650 PGOHUM00000262096
|
Genomic Variants
for GNG10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GNG10 (114423615 - 114432526 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GNG10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNG10 |
|
Disorders
/ Diseases
for GNG10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNG10 for disorders About GeneDecksing
OMIM gene information: 604389
OMIM disorders: --
4  diseases for GNG10: About MalaCardsmelanoma huntington's disease colorectal cancer breast cancer
Export disorders for GNG10 gene to outside databases
|
Publications
for GNG10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GNG10 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with GNG10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Novel somatic mutations in heterotrimeric G proteins in melanoma. (PubMed id 20424519)1 CA!rdenas-Navia L.I....Samuels Y. (2010)
- Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (2009)
- Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (2007)
- The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. (PubMed id 12782285)1 Rosskopf D....Siffert W. (2003)
- Glucagon and regulation of glucose metabolism. (PubMed id 12626323)1 Jiang G. and Zhang B.B. (2003)
|
External Searches for GNG10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNG10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNG10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNG10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GNG10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GNG10 gene:
Search GeneIP for patents involving GNG10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNG10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 |
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| |
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| | | | Tocris compounds for GNG10 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNG10 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNG10 |
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