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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB5 Gene

protein-coding   GIFtS: 66
GCID: GC15M052413

Guanine Nucleotide Binding Protein (G Protein), Beta 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta 51 2     gbeta52
Transducin Beta Chain 52 3     Guanine Nucleotide-Binding Protein Subunit Beta-52
GB52     Guanine Nucleotide-Binding Protein, Beta Subunit 5L2
G Protein, Beta Subunit 5L2     Gbeta53
G Protein, Beta-5 Subunit2     

External Ids:    HGNC: 44011   Entrez Gene: 106812   Ensembl: ENSG000000699667   OMIM: 6044475   UniProtKB: O147753   

Export aliases for GNB5 gene to outside databases

Previous GC identifers: GC15M047972 GC15M045460 GC15M049992 GC15M050129 GC15M050201 GC15M029244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNB5 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants
encoding different isoforms exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB5 Gene: 
GNB5 (guanine nucleotide binding protein (G protein), beta 5) is a protein-coding gene. Diseases associated with GNB5 include down syndrome, and huntington's disease, and among its related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB5 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB5 gene promoter:
         SRF   AML1a   POU2F1a   SRF (504 AA)   XBP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.1

GNB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052413:  view genomic region     (about GC identifiers)

Start:
52,413,117 bp from pter      End:
52,483,566 bp from pter
Size:
70,450 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit beta-5  
Size: 395 amino acids; 43566 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex
composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity)
Secondary accessions: Q9HAU9 Q9UFT3
Alternative splicing: 3 isoforms:  O14775-1   O14775-2   O14775-3   

Explore the universe of human proteins at neXtProt for GNB5: NX_O14775

Explore proteomics data for GNB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14775

  • GNB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNB5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006569.1  NP_057278.2  

    ENSEMBL proteins: 
     ENSP00000261837   ENSP00000379626   ENSP00000351635   ENSP00000453339   ENSP00000454185  
     ENSP00000453176  
    Reactome Protein details: O14775
    Human Recombinant Protein Products for GNB5: 
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    Novus Biologicals GNB5 Proteins
    Novus Biologicals GNB5 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005834heterotrimeric G-protein complex NAS--
    GO:0005886plasma membrane ----

    GNB5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry O14775

    ProtoNet protein and cluster: O14775

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    GNB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB5_HUMAN, O14775
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB5:
    guanine nucleotide binding protein 5,involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS9606987
    GO:0004871signal transducer activity NAS9606987
    GO:0005515protein binding ----
         
    GNB5 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnb5):
     behavior/neurological  cardiovascular system  growth/size  mortality/aging  muscle 
     nervous system  pigmentation  vision/eye 

    GNB5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gnb5tm1Ck for GNB5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNB5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNB5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNB5 
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    miRNA
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    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGNB5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNB5 About   (see all 64)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PI3Kgamma0.89
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.61
    Prostacyclin signalling through prostacyclin receptor0.77
    Glucagon-type ligand receptors0.58
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    3Thromboxane signalling through TP receptor
    Signal amplification0.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    ADP signalling through P2Y purinoceptor 10.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    4Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    5Visual signal transduction- Rods
    The phototransduction cascade0.54
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    Visual signal transduction- Rods0.54
    Visual signal transduction- Cones0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNB5 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB5 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNB5 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/7 BioSystems Pathways for GNB5 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Endothelin
    Thromboxane A2 receptor signaling

    5/44        Reactome Pathways for GNB5 (see all 44)
        G alpha (12/13) signalling events
    Platelet homeostasis
    Visual phototransduction
    G alpha (z) signalling events
    G-protein activation


    5/11         Kegg Pathways  (Kegg details for GNB5) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for GNB5 (O147752, 3 ENSP000002618374) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253308 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253308 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS9606987
    GO:0007165signal transduction NAS9606987
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    GNB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNB5 / GBB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNB5 gene (2 alternative transcripts): 
    NM_006578.3  NM_016194.3  

    Unigene Cluster for GNB5:

    Guanine nucleotide binding protein (G protein), beta 5
    Hs.155090  [show with all ESTs]
    Unigene Representative Sequence: NM_016194
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261837(uc002abr.1 uc002abs.1 uc002abt.1) ENST00000396335
    ENST00000557936 ENST00000358784 ENST00000559348 ENST00000560085 ENST00000558519
    ENST00000559541 ENST00000561313 ENST00000558122 ENST00000560075 ENST00000560116(uc002abu.3)

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNB5

    Additional mRNA sequence: 

    AF017656.1 AF300650.1 AF501885.1 AK094776.1 AK125702.1 AK290330.1 AK314775.1 AL117471.1 
    BC011671.2 BC013997.2 

    13 DOTS entries:

    DT.100777707  DT.452396  DT.40122317  DT.100671512  DT.100777706  DT.100800061  DT.95315095  DT.99976726 
    DT.91970754  DT.100676732  DT.95130172  DT.95275945  DT.95275949 

    24/178 AceView cDNA sequences (see all 178):

    AF501885 BM458790 BE780764 BQ718379 AK094776 AI279026 AI693612 AF300650 
    BG433762 AI470586 BU187041 BQ670836 BF589010 AI078395 BQ231747 BU175514 
    BQ925056 BQ673230 CR624892 BQ897627 AI744298 AA598532 AK125702 CB155675 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GNB5 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                  -           -                 -     -     -                             -                 -     -         
    SP2:        -     -     -     -                       -           -                 -     -     -                             -                 -     -         
    SP3:                                                                                            -                             -                 -     -         
    SP4:                                                  -           -                 -     -     -     -     -                                                   
    SP5:                                                  -     -     -                 -     -     -                                                               

    ExUns: 13c · 13d ^ 14a · 14b · 14c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for GNB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTAGGGG
    GNB5 Expression
    About this image


    See GNB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB5

    SOURCE GeneReport for Unigene cluster: Hs.155090

    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Tissue specificity: Expressed in multiple tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GNB5: 
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNB5 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb51 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 90.21(n)1
    99.24(a)1
      9 (42.30 cM)5
    146971  NM_010313.11  NP_034443.11 
     753113955 
    chicken
    (Gallus gallus)
    Aves GNB51 guanine nucleotide binding protein (G protein), beta more 83.21(n)
    94.94(a)
      415417  XM_413801.3  XP_413801.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNB56
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343479.1(25971-56763)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81472 Transcribed sequence with strong similarity to protein more 81.77(n)    BX729697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731962 hypothetical protein MGC73196 78.83(n)   393719  BC059544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;53
    Gbeta51
    G-protein coupled receptor protein
    signaling pathway more3
    CG10763-PA1
    68(a)3
    65.4(n)1
    69.01(a)1
      7D163
    317441  NM_132224.21  NP_572452.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-21 , 3 guanine nucleotide-binding protein3
    Protein GPB-21
    64(a)3
    58.7(n)1
    65.31(a)1
      I(7326544-7328973)3
    1724831  NM_059671.41  NP_492072.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE4(YOR212W)4
    STE41
    G protein beta subunit, forms a dimer with Ste18p to more4
    Ste4p1
    45.43(n)1
    40.17(a)1
      15(742910-744181)4
    8543871, 4  NP_014855.31  NP_014855.14 


    ENSEMBL Gene Tree for GNB5 (if available)
    TreeFam Gene Tree for GNB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB5 gene
    GNB22  GNB32  GNB12  WDR472  GNB42  
    18/32 SIMAP similar genes for GNB5 using alignment to 4 protein entries:     GBB5_HUMAN (see all proteins) (see all similar genes):
    GNB2    GNB4    GNB1    GNB3    WSB1    SMU1
    WDR61    RBBP4    TLE2    TLE3    TLE4    BRWD1
    SNRNP40    WDR86    DTL    TBL3    WDR17    WDR77

    GNB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1346 SNPs in GNB5 are shown (see all 1346)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178572091,2
    F--52412628(+) AGCATT/GCTCTG 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs749029411,2
    C,F--52412759(+) GGCCAC/TCTTTC 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1153787051,2
    C,F--52412776(+) TTCTCG/ATGCCT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs106641021,2
    C--52412831(+) AAAAA-/A/AA  
            
    TGGCT
    2 -- ds50011NA 2
    rs1919564221,2
    --52412902(+) GGACAC/TTCTGG 2 -- ds50010--------
    rs71779661,2
    C,F--52413050(+) GGAGGA/CAGGCA 2 -- ds500111Minor allele frequency- C:0.41NA WA CSA EA 372
    rs412777021,2
    --52413284(+) CCAGTC/TCTGTC 2 -- ut310--------
    rs1478511581,2
    C--52413297(+) TGGCT-/GG    
       GGGGG
    GTGCC
    2 -- ut310--------
    rs123961,2
    C,F,O,A,H--52413316(+) GCTCTG/CGAAGA 2 -- ut31 ese314Minor allele frequency- C:0.24MN NS EA NA CSA 1394
    rs1827973341,2
    C--52413617(+) AAACAA/GAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for GNB5 (52413117 - 52483566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GNB5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667228CNV Deletion23128226
    esv2571437CNV Deletion19546169
    nsv471244CNV Gain18288195
    nsv833005CNV Gain17160897


    Human Gene Mutation Database (HGMD): GNB5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604447    OMIM disorders: --

    9 diseases for GNB5:    About MalaCards
    down syndrome    huntington's disease    hepatitis b    retinitis
    colorectal cancer    hepatitis    alzheimer's disease    breast cancer
    neuronitis


    GNB5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNB5
    Human Genome Epidemiology (HuGE) Navigator: GNB5 (1 document)

    Export disorders for GNB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB5 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with GNB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue distribution of the human G protein beta 5 cDNA. (PubMed id 9606987)1, 2, 3, 9 Jones P.G.... Cockett M.I. (1998)
    2. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)1, 9 Howlett A.C....Willardson B.M. (2009)
    6. Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. (PubMed id 16135253)1, 9 Lwa S.H. and Chen W.N. (2005)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Type 5 G protein beta subunit (Gbeta5) controls the i nteraction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)1 Masuho I....Martemyanov K.A. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10681 HGNC: 4401 AceView: GNB5 Ensembl:ENSG00000069966 euGenes: HUgn10681
    ECgene: GNB5 Kegg: 10681 H-InvDB: GNB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNB5 gene:
    Search GeneIP for patents involving GNB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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