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Aliases for GNB5 Gene

Aliases for GNB5 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Beta 5 2 3
  • Transducin Beta Chain 5 3 4
  • Gbeta5 3 4
  • Guanine Nucleotide-Binding Protein, Beta Subunit 5L 3
  • Guanine Nucleotide-Binding Protein Subunit Beta-5 3
  • G Protein, Beta Subunit 5L 3
  • G Protein, Beta-5 Subunit 3
  • GB5 3

External Ids for GNB5 Gene

Previous GeneCards Identifiers for GNB5 Gene

  • GC15M047972
  • GC15M045460
  • GC15M049992
  • GC15M050129
  • GC15M050201
  • GC15M052413
  • GC15M029244

Summaries for GNB5 Gene

Entrez Gene Summary for GNB5 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNB5 Gene

GNB5 (Guanine Nucleotide Binding Protein (G Protein), Beta 5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNB4.

UniProtKB/Swiss-Prot for GNB5 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNB5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNB5 Gene

Genomics for GNB5 Gene

Regulatory Elements for GNB5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNB5 Gene

Start:
52,115,105 bp from pter
End:
52,191,369 bp from pter
Size:
76,265 bases
Orientation:
Minus strand

Genomic View for GNB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNB5 Gene

Proteins for GNB5 Gene

  • Protein details for GNB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14775-GBB5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit beta-5
    Protein Accession:
    O14775
    Secondary Accessions:
    • B2RBR5
    • Q9HAU9
    • Q9UFT3

    Protein attributes for GNB5 Gene

    Size:
    395 amino acids
    Molecular mass:
    43566 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity).

    Alternative splice isoforms for GNB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNB5 Gene

Proteomics data for GNB5 Gene at MOPED

Post-translational modifications for GNB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNB5 Gene

Antibody Products

No data available for DME Specific Peptides for GNB5 Gene

Domains for GNB5 Gene

Gene Families for GNB5 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

O14775

UniProtKB/Swiss-Prot:

GBB5_HUMAN :
  • O14775
Family:
  • Belongs to the WD repeat G protein beta family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with GNB5: view

Function for GNB5 Gene

Molecular function for GNB5 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein 5,involved in signal transduction
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 9606987
GO:0004871 signal transducer activity NAS 9606987
GO:0005515 protein binding IPI 12606627
GO:0031682 G-protein gamma-subunit binding IPI 12606627
GO:0051087 chaperone binding IPI 19376773
genes like me logo Genes that share ontologies with GNB5: view
genes like me logo Genes that share phenotypes with GNB5: view

Animal Models for GNB5 Gene

MGI Knock Outs for GNB5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNB5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNB5 Gene

Localization for GNB5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNB5 Gene COMPARTMENTS Subcellular localization image for GNB5 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for GNB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GNB5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNB5 Gene

Pathways for GNB5 Gene

SuperPathways for GNB5 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 fMLP Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with GNB5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction NAS 9606987
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process NAS 9606987
genes like me logo Genes that share ontologies with GNB5: view

Compounds for GNB5 Gene

(5) Tocris Compounds for GNB5 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNB5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNB5: view

Transcripts for GNB5 Gene

Unigene Clusters for GNB5 Gene

Guanine nucleotide binding protein (G protein), beta 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNB5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNB5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9:
SP10:

ExUns: 13c · 13d ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for GNB5 Gene

GeneLoc Exon Structure for
GNB5
ECgene alternative splicing isoforms for
GNB5

Expression for GNB5 Gene

mRNA expression in normal human tissues for GNB5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNB5 Gene

SOURCE GeneReport for Unigene cluster for GNB5 Gene Hs.155090

mRNA Expression by UniProt/SwissProt for GNB5 Gene

O14775-GBB5_HUMAN
Tissue specificity: Expressed in multiple tissues
genes like me logo Genes that share expressions with GNB5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GNB5 Gene

Orthologs for GNB5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNB5 35
  • 99.26 (n)
  • 99.68 (a)
GNB5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNB5 35
  • 93.67 (n)
  • 99.15 (a)
GNB5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNB5 35
  • 93.13 (n)
  • 99.48 (a)
GNB5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnb5 35
  • 90.21 (n)
  • 99.24 (a)
Gnb5 16
Gnb5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNB5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNB5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnb5 35
  • 91.41 (n)
  • 99.43 (a)
chicken
(Gallus gallus)
Aves GNB5 35
  • 83.21 (n)
  • 94.94 (a)
lizard
(Anolis carolinensis)
Reptilia GNB5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnb5 35
  • 81.3 (n)
  • 96.88 (a)
Str.8147 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11240 35
zebrafish
(Danio rerio)
Actinopterygii gnb3a 36
  • 49 (a)
OneToMany
gnb3b 36
  • 48 (a)
OneToMany
gnb5a 36
  • 90 (a)
OneToMany
gnb5b 35
  • 74.94 (n)
  • 84.81 (a)
gnb5b 36
  • 85 (a)
OneToMany
zgc73196 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012525 35
  • 63.75 (n)
  • 70.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gbeta5 35
  • 65.4 (n)
  • 69.01 (a)
Gbeta5 36
  • 66 (a)
OneToOne
Gbgr5 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea gpb-2 35
  • 58.7 (n)
  • 65.31 (a)
gpb-2 36
  • 64 (a)
OneToOne
gpb-2 37
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR097W 35
  • 46.31 (n)
  • 39.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE4 35
  • 45.97 (n)
  • 40.73 (a)
STE4 36
  • 32 (a)
OneToMany
STE4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06787g 35
  • 48.4 (n)
  • 41.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10984 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2578 36
  • 56 (a)
OneToOne
Species with no ortholog for GNB5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNB5 Gene

ENSEMBL:
Gene Tree for GNB5 (if available)
TreeFam:
Gene Tree for GNB5 (if available)

Paralogs for GNB5 Gene

Paralogs for GNB5 Gene

genes like me logo Genes that share paralogs with GNB5: view

Variants for GNB5 Gene

Sequence variations from dbSNP and Humsavar for GNB5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12396 -- 52,121,119(+) GCTCT(C/G)GAAGA utr-variant-3-prime
rs730945 -- 52,155,350(+) TGTGC(C/T)GAGAG intron-variant
rs1135083 -- 52,133,395(-) GAATC(C/T)GACAT synonymous-codon, reference
rs2288559 -- 52,154,267(+) GTAGA(C/G)GGTAG intron-variant
rs2288560 -- 52,154,298(+) CTTTG(C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNB5 Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV Gain 18288195
nsv833005 CNV Gain 17160897
esv2667228 CNV Deletion 23128226
esv2571437 CNV Deletion 19546169

Relevant External Links for GNB5 Gene

HapMap Linkage Disequilibrium report
GNB5
Human Gene Mutation Database (HGMD)
GNB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB5 Gene

Disorders for GNB5 Gene

Relevant External Links for GNB5

Genetic Association Database (GAD)
GNB5
Human Genome Epidemiology (HuGE) Navigator
GNB5
genes like me logo Genes that share disorders with GNB5: view

No data available for UniProtKB/Swiss-Prot for GNB5 Gene

Publications for GNB5 Gene

  1. Cloning and tissue distribution of the human G protein beta 5 cDNA. (PMID: 9606987) Jones P.G. … Cockett M.I. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PMID: 19376773) Howlett A.C. … Willardson B.M. (J. Biol. Chem. 2009) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. (PMID: 16135253) Lwa S.H. … Chen W.N. (Virol. J. 2005) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for GNB5 Gene

Sources for GNB5 Gene

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