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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB5 Gene

protein-coding   GIFtS: 65
GCID: GC15M052413

guanine nucleotide binding protein (G protein), beta 5
 Explore 8 diseases affiliated with
GNB5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GNB5    

Aliases
for GNB5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta 51 2     Gbeta53
GB51 2     Guanine Nucleotide-Binding Protein Subunit Beta-52
Transducin Beta Chain 52 3     Guanine Nucleotide-Binding Protein, Beta Subunit 5L2
G Protein, Beta Subunit 5L2     Gbeta53
G Protein, Beta-5 Subunit2     

External Ids:    HGNC: 44011   Entrez Gene: 106812   Ensembl: ENSG000000699667   OMIM: 6044475   UniProtKB: O147753   

Export aliases for GNB5 gene to outside databases

Previous GC identifers: GC15M047972 GC15M045460 GC15M049992 GC15M050129 GC15M050201 GC15M029244


Summaries
for GNB5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNB5:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector
proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related
genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of
certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different
isoforms exist. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
GDP by GTP, and for G protein-effector interaction

summary for GNB5:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB5


Genomic Views
for GNB5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB5 gene promoter:
         SRF   AML1a   POU2F1a   SRF (504 AA)   XBP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.1

GNB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052413:  view genomic region     (about GC identifiers)

Start:
 52,413,117 bp from pter      End:
 52,483,566 bp from pter
Size:
 70,450 bases      Orientation:
 minus strand

Proteins
for GNB5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit beta-5  
Size: 395 amino acids; 43566 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of
RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity)
Secondary accessions: Q9HAU9 Q9UFT3
Alternative splicing: 3 isoforms:  O14775-1   O14775-2   O14775-3   

Explore the universe of human proteins at neXtProt for GNB5: NX_O14775

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14775

    • GNB5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006569.1  NP_057278.2  

    ENSEMBL proteins: 
     ENSP00000261837   ENSP00000379626   ENSP00000351635   ENSP00000453339   ENSP00000454185  
     ENSP00000453176  
    Reactome Protein details: O14775
    Human Recombinant Protein Products: 
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    Novus Biologicals GNB5 Proteins
    Novus Biologicals GNB5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005834heterotrimeric G-protein complex NAS--
    GO:0005886plasma membrane ----


    GNB5 for ontologies           About GeneDecksing



    GNB5 Antibody Products: 
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    ThermoFisher Antibodies for GNB5

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GNB5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNB5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry O14775

    ProtoNet protein and cluster: O14775

    2 Blocks protein families:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Function
    for GNB5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
    GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB5:
    guanine nucleotide binding protein 5,involved in signal transduction

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): GNB5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNB5
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB5 (see all 33):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: GNB5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB5 (see all 6)
    OriGene siRNA: GNB5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GNB5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNB5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNB5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GNB5 (NM_016194)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB5 

    Cell Line
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    Search LifeMap BioReagents cell lines for GNB5

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS9606987
    GO:0004871signal transducer activity NAS9606987


    GNB5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Gnb5tm1Ck for GNB5
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gnb5):
     behavior/neurological  cardiovascular system  growth/size  mortality/aging  muscle 
     nervous system  pigmentation  vision/eye 

    GNB5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GNB5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/66 super-pathways (see all 66) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G beta:gamma signalling through PLC beta
    8/13 pathways (see all 13)
    		G beta:gamma signalling through PLC beta1.00
    		Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.55
    		Presynaptic function of Kainate receptors0.95
    		G-protein activation0.55
    		Prostacyclin signalling through prostacyclin receptor0.77
    		Glucagon-type ligand receptors0.52
    		G-protein beta:gamma signalling0.71
    		G-Protein Signaling through Tubby Protein0.38
    2Development Angiotensin activation of ERK
    8/9 pathways (see all 9)
    		Development Angiotensin activation of ERK1.00
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development_EDNRB signaling0.54
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    3Development_A3 receptor signaling
    		Development_A3 receptor signaling1.00
    		Development A1 receptor signaling0.65
    		Development A3 receptor signaling1.00
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		Development_A1 receptor signaling0.65
    		G-protein signaling G-Protein alpha-q signaling cascades0.53
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Development_Dopamine D2 receptor transactivation of EGFR
    		Development_Dopamine D2 receptor transactivation of EGFR1.00
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		Development Dopamine D2 receptor transactivation of EGFR1.00
    		Chemotaxis_CXCR4 signaling pathway0.48
    		Development_Alpha-2 adrenergic receptor activation of ERK0.66
    		Chemotaxis CXCR4 signaling pathway0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/31 EMD Millipore Pathways for GNB5 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB5 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNB5 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/7 BioSystems Pathways for GNB5 (see all 7) 
        G Protein Signaling Pathways
    Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    Endothelin
    Visual signal transduction- Rods

    5/39        Reactome Pathways for GNB5 (see all 39)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G alpha (z) signalling events
    G-protein activation
    Signal Transduction


    3         Kegg Pathways  (Kegg details for GNB5):
        Chemokine signaling pathway
    Glutamatergic synapse
    Cholinergic synapse


    GNB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for GNB5 (O147752, 3 ENSP000002618374) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR6A1Q154062, 3, ENSP000004202674MINT-63075 I2D: score=4 STRING: ENSP00000420267
    MCM2P497362, 3MINT-63073 I2D: score=5 
    OLFM2O958972, 3MINT-63321 I2D: score=4 
    ANXA7P200732, 3MINT-8248428 I2D: score=2 
    CDKN1AP389362, 3MINT-8251937 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS9606987
    GO:0007165signal transduction NAS9606987
    GO:0007186G-protein coupled receptor signaling pathway IEA--


    GNB5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNB5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    GRK2iGRK2 inhibitory polypeptide. Gbetagamma antagonist[148505-03-7]

    3 HMDB Compounds for GNB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about GNB5 / GBB5 

    Transcripts
    for GNB5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNB5 gene (2 alternative transcripts): 
    NM_006578.3  NM_016194.3  

    Unigene Cluster for GNB5:

    Guanine nucleotide binding protein (G protein), beta 5
    Hs.155090  [show with all ESTs]
    Unigene Representative Sequence: NM_016194
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261837(uc002abr.1 uc002abs.1 uc002abt.1) ENST00000396335
    ENST00000557936 ENST00000358784 ENST00000559348 ENST00000560085 ENST00000558519
    ENST00000559541 ENST00000561313 ENST00000558122 ENST00000560075 ENST00000560116(uc002abu.3)


    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB5 (see all 33):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: GNB5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB5 (see all 6)
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNB5 (NM_016194)
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    Primer
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    Additional cDNA sequence: 

    AF017656.1 AF300650.1 AF501885.1 AK094776.1 AK125702.1 AK290330.1 AK314775.1 AL117471.1 
    BC011671.2 BC013997.2 

    13 DOTS entries:

    DT.100777707  DT.452396  DT.40122317  DT.100671512  DT.100777706  DT.100800061  DT.95315095  DT.99976726 
    DT.91970754  DT.100676732  DT.95130172  DT.95275945  DT.95275949 

    24/178 AceView cDNA sequences (see all 178):

    AI693612 AK094776 BQ673230 BE222091 AA296662 CB155675 CB127276 AI470586 
    BQ710553 BQ897627 BU175514 BE326589 BM458790 BG433762 BU187041 CR624892 
    BQ670836 AI124703 BC013997 CF265113 AA598532 AK125702 BQ718379 BM722866 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GNB5 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                  -           -                 -     -     -                             -                 -     -         
    SP2:        -     -     -     -                       -           -                 -     -     -                             -                 -     -         
    SP3:                                                                                            -                             -                 -     -         
    SP4:                                                  -           -                 -     -     -     -     -                                                   
    SP5:                                                  -     -     -                 -     -     -                                                               

    ExUns: 13c · 13d ^ 14a · 14b · 14c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for GNB5

    Expression
    for GNB5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCTAGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GNB5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GNB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB5

    SOURCE GeneReport for Unigene cluster: Hs.155090

    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Tissue specificity: Expressed in multiple tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GNB5: 
              Alzheimer's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for GNB5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNB5 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNB51 guanine nucleotide binding protein (G protein), beta more 83.21(n)
    94.94(a)    		   415417  XM_413801.3  XP_413801.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GNB56
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343479.1(25971-56763)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.81472 Transcribed sequence with strong similarity to protein more 81.77(n)    BX729697.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc731962 hypothetical protein MGC73196 78.83(n)   393719  BC059544.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta G&bgr;53
    Gbeta51    		 G-protein coupled receptor protein signaling
    pathway more3
    CG10763-PA1    		 68(a)3
    65.4(n)1
    69.01(a)1    		   7D163
    317441  NM_132224.21  NP_572452.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea gpb-21 , 3 guanine nucleotide-binding protein3
    Protein GPB-21    		 64(a)3
    58.7(n)1
    65.31(a)1    		   I(7326544-7328973)3
    1724831  NM_059671.41  NP_492072.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes STE4(YOR212W)4
    STE41    		 G protein beta subunit, forms a dimer with Ste18p to more4
    Ste4p1    		 45.43(n)1
    40.17(a)1    		   15(742910-744181)4
    8543871, 4  NP_014855.31  NP_014855.14 


    ENSEMBL Gene Tree for GNB5 (if available)
    TreeFam Gene Tree for GNB5 (if available) 

    Paralogs
    for GNB5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB5 gene
    GNB22  GNB32  GNB12  WDR472  GNB42  
    18/35 SIMAP similar genes for GNB5 using alignment to 4 protein entries:     GBB5_HUMAN (see all proteins) (see all similar genes):
    GNB2    GNB4    GNB1    GNB3    WSB1    SMU1
    WDR61    RBBP4    TLE2    TLE3    TLE4    BRWD1
    SNRNP40    WDR86    DTL    TBL1Y    TBL3    WDR17

    GNB5 for paralogs           About GeneDecksing



    Genomic Variants
    for GNB5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1432 NCBI SNPs in GNB5 are shown (see all 1432)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs749462951,2
    		F,--29301245(+) ATCCAG/AGCATG 1 -- us2k12Minor allele frequency- A:0.06WA NA 238
    rs787139421,2
    		F,--29301635(+) ATCATA/GTTATA 1 -- us2k12Minor allele frequency- G:0.06WA NA 238
    rs753580091,2
    		F,--29302676(+) GATAGC/ATAGTC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs727349191,2
    		C,--29303276(+) CGTCAC/GCCTCT 1 -- nc-transcript-variant0--------
    rs1130735221,2
    		C,--29303395(+) GCCGGG/TANNNN 1 -- nc-transcript-variant2Minor allele frequency- T:0.08NA EA 122
    rs558604101,2
    		C,F,--29303630(+) GTTGAT/GCTAAA 1 -- nc-transcript-variant1Minor allele frequency- G:0.03NA 120
    rs1156716771,2
    		C,F,--29303751(+) GGGCGG/ACAAAA 1 -- nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs791168091,2
    		F,--29304019(+) GAATGG/AGCACA 1 -- nc-transcript-variant1Minor allele frequency- A:0.10WA 118
    rs1181120621,2
    		C,F,--29304305(+) CTCTCT/CGTACC 1 -- nc-transcript-variant1Minor allele frequency- C:0.03EA 120
    rs71833091,2
    		C,--29304564(+) aggtgA/Ggtgta 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNB5 (52413117 - 52483566 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GNB5
         1 CNV: 102103
    Human Gene Mutation Database (HGMD): GNB5

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    Disorders / Diseases
    for GNB5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNB5 for disorders           About GeneDecksing

    OMIM gene information: 604447    OMIM disorders: --

    8 diseases for GNB5:    About MalaCards
    down syndrome    hepatitis b    pharyngitis    hepatitis
    retinitis    huntington's disease    colorectal cancer    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: GNB5 (1 document)

    Export disorders for GNB5 gene to outside databases

    Publications
    for GNB5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB5 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with GNB5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue distribution of the human G protein beta 5 cDNA. (PubMed id 9606987)1, 2, 3, 9 Jones P.G.... Cockett M.I. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Role of molecular chaperones in G protein beta5/regul ator of G protein signaling dimer assembly and G protein betagamma dimer specif icity. (PubMed id 19376773)1, 9 Howlett A.C....Willardson B.M. (2009)
    5. Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. (PubMed id 16135253)1, 9 Lwa S.H. and Chen W.N. (2005)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Type 5 G protein beta subunit (Gbeta5) controls the i nteraction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)1 Masuho I....Martemyanov K.A. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for GNB5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing GNB5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10681 HGNC: 4401 AceView: GNB5 Ensembl:ENSG00000069966 euGenes: HUgn10681
    ECgene: GNB5 Kegg: 10681 H-InvDB: GNB5

    Other Databases showing GNB5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNB5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNB5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNB5 gene:
    Search GeneIP for patents involving GNB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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