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GNB5 Gene

protein-coding   GIFtS: 66
GCID: GC15M052413

Guanine Nucleotide Binding Protein (G Protein), Beta 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta 51 2     gbeta52
Transducin Beta Chain 52 3     Guanine Nucleotide-Binding Protein Subunit Beta-52
GB52     Guanine Nucleotide-Binding Protein, Beta Subunit 5L2
G Protein, Beta Subunit 5L2     Gbeta53
G Protein, Beta-5 Subunit2     

External Ids:    HGNC: 44011   Entrez Gene: 106812   Ensembl: ENSG000000699667   OMIM: 6044475   UniProtKB: O147753   

Export aliases for GNB5 gene to outside databases

Previous GC identifers: GC15M047972 GC15M045460 GC15M049992 GC15M050129 GC15M050201 GC15M029244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNB5 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants
encoding different isoforms exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB5 Gene:
GNB5 (guanine nucleotide binding protein (G protein), beta 5) is a protein-coding gene. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB5 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNB5 gene promoter:
         SRF   AML1a   POU2F1a   SRF (504 AA)   XBP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GNB5 promoter sequence
   Search Chromatin IP Primers for GNB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.1

GNB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052413:  view genomic region     (about GC identifiers)

Start:
52,413,117 bp from pter      End:
52,483,566 bp from pter
Size:
70,450 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit beta-5  
Size: 395 amino acids; 43566 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex
composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity)
Secondary accessions: B2RBR5 Q9HAU9 Q9UFT3
Alternative splicing: 3 isoforms:  O14775-1   O14775-2   O14775-3   

Explore the universe of human proteins at neXtProt for GNB5: NX_O14775

Explore proteomics data for GNB5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006569.1  NP_057278.2  

    ENSEMBL proteins: 
     ENSP00000261837   ENSP00000379626   ENSP00000351635   ENSP00000453339   ENSP00000454185  
     ENSP00000453176  
    Reactome Protein details: O14775

    GNB5 Human Recombinant Protein Products:

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    Novus Biologicals GNB5 Proteins
    Novus Biologicals GNB5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNB5 

     
    antibodies-online proteins for GNB5 (10 products) 

     
    antibodies-online peptides for GNB5

    GNB5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNB5
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    antibodies-online antibodies for GNB5 (41 products) 

    GNB5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNB5 
    antibodies-online kits for GNB5 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry O14775

    ProtoNet protein and cluster: O14775

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with GNB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB5_HUMAN, O14775
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB5:
    guanine nucleotide binding protein 5,involved in signal transduction

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS9606987
    GO:0004871signal transducer activity NAS9606987
    GO:0005515protein binding IPI12606627
    GO:0031682G-protein gamma-subunit binding IPI12606627
    GO:0051087chaperone binding IPI19376773
         
    Find genes that share ontologies with GNB5           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnb5):
     behavior/neurological  cardiovascular system  growth/size/body  mortality/aging  muscle 
     nervous system  pigmentation  vision/eye 

    Find genes that share phenotypes with GNB5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gnb5tm1Ck for GNB5

       genOway: Develop your customized and physiologically relevant rodent model for GNB5

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNB5:
    hsa-mir-148a-3p (MIRT025993), hsa-mir-425-5p (MIRT039346), hsa-mir-128-3p (MIRT021914), hsa-mir-27a-3p (MIRT028691), hsa-mir-130b-3p (MIRT020117), hsa-mir-26b-5p (MIRT028825)

    Block miRNA regulation of human, mouse, rat GNB5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNB5 (see all 33):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGNB5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNB5

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    Clone
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    OriGene clones in human, mouse for GNB5 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNB5 (NM_016194)
    Sino Biological Human cDNA Clone for GNB5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005834heterotrimeric G-protein complex ----
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with GNB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNB5 About   (see all 65)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    G-protein activation0.74
    G beta-gamma signalling through PI3Kgamma0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Signal amplification0.79
    Activation of Kainate Receptors upon glutamate binding0.68
    ADP signalling through P2Y purinoceptor 10.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    Visual signal transduction- Rods0.51
    Visual signal transduction- Cones0.39
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58


    Find genes that share SuperPaths with GNB5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNB5 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNB5 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for GNB5 (see all 8)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone
    Endothelin


    Selected Reactome Pathways for GNB5 (see all 20)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    Inactivation, recovery and regulation of the phototransduction cascade
    G-protein activation
    Ca2+ pathway


    Selected Kegg Pathways  (Kegg details for GNB5) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Array including GNB5: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GNB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNB5 (O147752, 3 ENSP000002618374) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253308 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253308 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253308 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS9606987
    GO:0007165signal transduction NAS9606987
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    Find genes that share ontologies with GNB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNB5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNB5 gene (2 alternative transcripts): 
    NM_006578.3  NM_016194.3  

    Unigene Cluster for GNB5:

    Guanine nucleotide binding protein (G protein), beta 5
    Hs.155090  [show with all ESTs]
    Unigene Representative Sequence: NM_016194
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261837(uc002abr.1 uc002abs.1 uc002abt.1) ENST00000396335
    ENST00000557936 ENST00000358784 ENST00000559348 ENST00000560085 ENST00000558519
    ENST00000559541 ENST00000561313 ENST00000558122 ENST00000560075 ENST00000560116(uc002abu.3)

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    Selected qRT-PCR Assays for microRNAs that regulate GNB5 (see all 33):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGNB5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNB5
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNB5 (NM_016194)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB5
    Primer
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    OriGene qPCR primer pairs and template standards for GNB5
    OriGene qSTAR qPCR primer pairs in human, mouse for GNB5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB5
      QuantiTect SYBR Green Assays in human, mouse, rat GNB5
      QuantiFast Probe-based Assays in human, mouse, rat GNB5

    Additional mRNA sequence: 

    AF017656.1 AF300650.1 AF501885.1 AK094776.1 AK125702.1 AK290330.1 AK314775.1 AL117471.1 
    BC011671.2 BC013997.2 

    13 DOTS entries:

    DT.100777707  DT.452396  DT.40122317  DT.100671512  DT.100777706  DT.100800061  DT.95315095  DT.99976726 
    DT.91970754  DT.100676732  DT.95130172  DT.95275945  DT.95275949 

    Selected AceView cDNA sequences (see all 178):

    AK094776 BQ710553 BG433762 BQ897627 BE780764 BU175514 CB127276 AI279026 
    BQ673230 CF265113 BE326589 AI744298 BE348764 AF300650 AI470586 AI693612 
    AI124703 CF264974 BE222091 BU187041 AF501885 BI871051 AK125702 CR624892 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNB5 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                  -           -                 -     -     -                             -                 -     -         
    SP2:        -     -     -     -                       -           -                 -     -     -                             -                 -     -         
    SP3:                                                                                            -                             -                 -     -         
    SP4:                                                  -           -                 -     -     -     -     -                                                   
    SP5:                                                  -     -     -                 -     -     -                                                               

    ExUns: 13c · 13d ^ 14a · 14b · 14c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for GNB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTAGGGG
    GNB5 Expression
    About this image

    GNB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155090

    UniProtKB/Swiss-Prot: GBB5_HUMAN, O14775
    Tissue specificity: Expressed in multiple tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including GNB5: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNB5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb51 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 90.21(n)1
    99.24(a)1
      9 (42.30 cM)5
    146971  NM_010313.21  NP_034443.11 
     753113955 
    chicken
    (Gallus gallus)
    Aves GNB51 guanine nucleotide binding protein (G protein), beta more 83.21(n)
    94.94(a)
      415417  XM_413801.4  XP_413801.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNB56
    guanine nucleotide binding protein (G protein), be...
    93(a)
    1 ↔ 1
    GL343479.1(25971-56763)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81472 Transcribed sequence with strong similarity to protein more 81.77(n)    BX729697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731962 hypothetical protein MGC73196 78.83(n)   393719  BC059544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;53
    Gbeta51
    G-protein coupled receptor protein
    signaling pathway more3
    Gbeta51
    68(a)3
    65.4(n)1
    69.01(a)1
      7D163
    317441  NM_132224.31  NP_572452.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-21 , 3 guanine nucleotide-binding protein3
    gpb-21
    64(a)3
    58.7(n)1
    65.31(a)1
      I(7326544-7328973)3
    1724831  NM_059671.51  NP_492072.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE4(YOR212W)4
    STE41
    G protein beta subunit, forms a dimer with Ste18p to more4
    STE41
    45.97(n)1
    40.73(a)1
      15(742910-744181)4
    8543871, 4  NP_014855.31  NP_014855.14 


    ENSEMBL Gene Tree for GNB5 (if available)
    TreeFam Gene Tree for GNB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNB5 gene
    GNB22  GNB32  GNB12  WDR472  GNB42  
    Selected SIMAP similar genes for GNB5 using alignment to 4 protein entries:     GBB5_HUMAN (see all proteins) (see all similar genes):
    GNB2    GNB4    GNB1    GNB3    WSB1    SMU1
    WDR61    RBBP4    TLE2    TLE3    TLE4    BRWD1
    SNRNP40    WDR86    DTL    TBL3    WDR17    WDR77

    Find genes that share paralogs with GNB5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNB5 (see all 1346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178572091,2
    F--52412628(+) AGCATT/GCTCTG 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs749029411,2
    C,F--52412759(+) GGCCAC/TCTTTC 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1153787051,2
    C,F--52412776(+) TTCTCG/ATGCCT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs106641021,2
    C--52412831(+) AAAAA-/A/AA  
            
    TGGCT
    2 -- ds50011NA 2
    rs1919564221,2
    --52412902(+) GGACAC/TTCTGG 2 -- ds50010--------
    rs71779661,2
    C,F--52413050(+) GGAGGA/CAGGCA 2 -- ds500111Minor allele frequency- C:0.41NA WA CSA EA 372
    rs412777021,2
    --52413284(+) CCAGTC/TCTGTC 2 -- ut310--------
    rs1478511581,2
    C--52413297(+) TGGCT-/GG    
       GGGGG
    GTGCC
    2 -- ut310--------
    rs123961,2
    C,F,O,A,H--52413316(+) GCTCTG/CGAAGA 2 -- ut31 ese314Minor allele frequency- C:0.24MN NS EA NA CSA 1394
    rs1827973341,2
    C--52413617(+) AAACAA/GAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for GNB5 (52413117 - 52483566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GNB5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667228CNV Deletion23128226
    esv2571437CNV Deletion19546169
    nsv471244CNV Gain18288195
    nsv833005CNV Gain17160897

    Human Gene Mutation Database (HGMD): GNB5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNB5
    DNA2.0 Custom Variant and Variant Library Synthesis for GNB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604447    OMIM disorders: --


    Find genes that share disorders with GNB5           About GenesLikeMe

    Genetic Association Database (GAD): GNB5
    Human Genome Epidemiology (HuGE) Navigator: GNB5 (1 document)

    Export disorders for GNB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNB5 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with GNB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue distribution of the human G protein beta 5 cDNA. (PubMed id 9606987)1, 2, 3, 9 Jones P.G.... Cockett M.I. (Biochim. Biophys. Acta 1998)
    2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1, 9 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    7. Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. (PubMed id 16135253)1, 9 Lwa S.H. and Chen W.N. (Virol. J. 2005)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)1 Masuho I....Martemyanov K.A. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10681 HGNC: 4401 AceView: GNB5 Ensembl:ENSG00000069966 euGenes: HUgn10681
    ECgene: GNB5 Kegg: 10681 H-InvDB: GNB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNB5 gene:
    Search GeneIP for patents involving GNB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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