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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNB4 Gene

protein-coding GIFtS: 61
GCID: GC03M179113

guanine nucleotide binding protein (G protein), beta polypeptide...

Explore 9 diseases affiliated with
GNB4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 4¹ ²
Transducin Beta Chain 4² ³
G Protein Beta-4 Subunit²
Guanine Nucleotide Binding Protein Beta Subunit 4²
Guanine Nucleotide-Binding Protein Subunit Beta-4²

External Ids:	HGNC: 20731¹	Entrez Gene: 59345²	Ensembl: ENSG00000114450⁷	OMIM: 610863⁵	UniProtKB: Q9HAV0³

Export aliases for GNB4 gene to outside databases

Previous GC identifers: GC03M175882 GC03M179959 GC03M180519 GC03M180437 GC03M180599 GC03M176517

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNB4:

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector

proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related

genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of

certain signal transduction receptors and effectors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBB4_HUMAN, Q9HAV0

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

summary for GNB4:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; in addition, some

Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and

Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNB4 gene promoter:
Sox5 NF-AT C/EBPalpha AREB6 CHOP-10 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNB4 promoter sequence

Search SABiosciences Chromatin IP Primers for GNB4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q27.1

GNB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB4 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M179113: view genomic region (about GC identifiers)

Start:	179,113,876 bp from pter	End:	179,169,378 bp from pter
Size:	55,503 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBB4_HUMAN, Q9HAV0 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein subunit beta-4

Size: 340 amino acids; 37567 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma

Secondary accessions: B3KMH5 D3DNR8

Explore the universe of human proteins at neXtProt for GNB4: NX_Q9HAV0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HAV0

GNB4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067642.1

ENSEMBL proteins:

ENSP00000232564 ENSP00000420066 ENSP00000419693 ENSP00000420606

Reactome Protein details: Q9HAV0
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--

GNB4 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNB4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR019775 WD40_repeat_CS

IPR016346 Guanine_nucleotide-bd_bsu

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR001632 Gprotein_B

Graphical View of Domain Structure for InterPro Entry Q9HAV0

ProtoNet protein and cluster: Q9HAV0

2 Blocks protein families:

IPB001632 Beta G-protein (transducin) signature

IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: GBB4_HUMAN, Q9HAV0

Similarity: Belongs to the WD repeat G protein beta family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GBB4_HUMAN, Q9HAV0

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various

transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of

GDP by GTP, and for G protein-effector interaction

Genatlas biochemistry entry for GNB4:

guanine nucleotide binding protein 4

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		hsa-miR-124* hsa-miR-576-3p hsa-miR-1321 hsa-miR-300 hsa-miR-513a-5p hsa-miR-29a hsa-miR-200a hsa-miR-624

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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--

GNB4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/63 super-pathways (see all 63) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

8/13 pathways (see all 13)
G beta:gamma signalling through PLC beta	1.00	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.55
Presynaptic function of Kainate receptors	0.95	G-protein activation	0.55
Prostacyclin signalling through prostacyclin receptor	0.77	Glucagon-type ligand receptors	0.52
G-protein beta:gamma signalling	0.71	G-Protein Signaling through Tubby Protein	0.38

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/31 EMD Millipore Pathways for GNB4 (see all 31)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling

5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB4 (see all 71)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	JNK Pathway
	ERK5 Signaling

5/34 GeneGo (Thomson Reuters) Pathways for GNB4 (see all 34)

	Signal transduction cAMP signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Signal transduction Activation of PKC via G-Protein coupled receptor

2 BioSystems Pathways for GNB4

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell

5/40 Reactome Pathways for GNB4 (see all 40)

	G alpha (12/13) signalling events
	Platelet homeostasis
	G alpha (z) signalling events
	G-protein activation
	Signal Transduction

1 PharmGKB Pathway for GNB4

Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for GNB4):

	Chemokine signaling pathway
	Glutamatergic synapse
	Cholinergic synapse

GNB4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNB4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for GNB4 (Q9HAV0^{2, 3} ENSP00000232564⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RIPK3	Q9Y572²^,³	MINT-49095 I2D: score=2
GNG13	Q9P2W3³, ENSP00000248150⁴	I2D: score=2 STRING: ENSP00000248150
GNG4	P50150³, ENSP00000355556⁴	I2D: score=2 STRING: ENSP00000355556
GNG5	P63218³, ENSP00000359675⁴	I2D: score=2 STRING: ENSP00000359675
MTNR1B	P49286³, ENSP00000257068⁴	I2D: score=2 STRING: ENSP00000257068

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0071377	cellular response to glucagon stimulus	TAS	--

GNB4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNB4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Gallein	Inhibitor of betagamma signaling	[2103-64-2]
GRK2i	GRK2 inhibitory polypeptide. Gbetagamma antagonist	[148505-03-7]

3 HMDB Compounds for GNB4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNB4 / GBB4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNB4 gene:

NM_021629.3

Unigene Cluster for GNB4:

Guanine nucleotide binding protein (G protein), beta polypeptide 4

Hs.173030 [show with all ESTs]

Unigene Representative Sequence: NM_021629

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000232564(uc003fju.4 uc003fjv.4) ENST00000466899 ENST00000468623

ENST00000465153 ENST00000497513

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Additional cDNA sequence:

AF300648.1 AK001890.1 AK022599.1 AK091332.1 AK290571.1 AK297174.1 AK310009.1 BC000873.1

8 DOTS entries:

DT.208481 DT.414962 DT.100729086 DT.120864996 DT.100035740 DT.100683393 DT.120865021 DT.91866943

24/157 AceView cDNA sequences (see all 157):

AF300648 CR603437 AU279411 CB044347 BM983589 BX110271 BM989578 AW630232

N64377 AA780563 AW956198 BE907043 BE018289 CA441595 N54076 AA040196

BI906715 AW872774 AI457737 BG059574 BC000873 AA296479 AU077120 AL596957

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GNB4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b
SP1:					-		-
SP2:							-
SP3:					-
SP4:																											-

ECgene alternative splicing isoforms for GNB4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTAACTGT

About this image

GNB4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Valves

Heart

Heart

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNB4

SOURCE GeneReport for Unigene cluster: Hs.173030

UniProtKB/Swiss-Prot: GBB4_HUMAN, Q9HAV0

Tissue specificity: Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart

SABiosciences Expression via Pathway-Focused PCR Array including GNB4:

Alzheimer's Disease in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNB4 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNB4¹	guanine nucleotide binding protein (G protein), beta more	83.85(n) 95.06(a)		424974 XM_003641774.1 XP_003641822.1
lizard (Anolis carolinensis)	Reptilia	GNB4⁶	--	95(a)	1 ↔ 1	3(2226808-2238565)
zebrafish (Danio rerio)	Actinopterygii	zgc:101614⁶ CABZ01087197.1⁶	--	89(a) 89(a)	possible ortholog 1 ↔ 1	11(45322434-45355583) 2(4530979-4541827)
fruit fly (Drosophila melanogaster)	Insecta	G&bgr;13F³	G-protein coupled receptor protein signaling pathway more	81(a) (best of 2)		13F16 --
worm (Caenorhabditis elegans)	Secernentea	gpb-1³	guanine nucleotide-binding protein beta subunit	84(a)		II(11743881-11747549) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ELK4⁶	guanine nucleotide-binding protein subunit beta	42(a)	1 → many	4(16477106-16479528)
rice (Oryza sativa)	Liliopsida	--	WD domain, G-beta repeat domain containing protein...	42(a)	1 → many	3(26391617-26399638)

ENSEMBL Gene Tree for GNB4 (if available)
TreeFam Gene Tree for GNB4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNB4 gene

GNB2² GNB3² GNB1² WDR47² GNB5²

8 SIMAP similar genes for GNB4 using alignment to 3 protein entries: GBB4_HUMAN (see all proteins):

GNB2 GNB1 GNB3 GNB5 WDR61 GNB2L1

PF20 WDR83

GNB4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3853152^1,2	C,F,A,H,	--	179113395(+)	`AGCATC/TGCTTA`	1	--	ds500¹		9		EA NS NA WA	562
rs145857873^1,2	C,	--	179113540(+)	`AAAAA-/CTTCTTTT`	1	--	ds500¹		0	--	--	--	--
rs146374924^1,2		--	179113656(+)	`CAACAC/TAGACC`	1	--	ds500¹		0	--	--	--	--
rs148528513^1,2		--	179113709(+)	`ATGCAA/CGTACC`	1	--	ds500¹		0	--	--	--	--
rs185139111^1,2		--	179113733(+)	`ACTCCA/GGAGGC`	1	--	ds500¹		0	--	--	--	--
rs9815742^1,2	C,	--	179113764(+)	`agcacA/Gggagg`	1	--	ds500¹		0	--	--	--	--
rs151034608^1,2		--	179113765(+)	`GCACGC/GGAGGC`	1	--	ds500¹		0	--	--	--	--
rs140915061^1,2		--	179113817(+)	`CTGGGA/CAAGAG`	1	--	ds500¹		0	--	--	--	--
rs11293334^1,2	C	--	179113835(+)	`CTCTC-/AAAAAA`	1	--	ds500¹		2		NA CSA	4
rs58502666^1,2	C	--	179113835(+)	`AAAAA-/ATTGTG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GNB4 (179113876 - 179169378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GNB4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GNB4 for disorders           About GeneDecksing

OMIM gene information: 610863    OMIM disorders: --

9 diseases for GNB4:    About MalaCards

essential hypertension bladder carcinoma hypertension retinitis

carcinoma neuronitis huntington's disease colorectal cancer

breast cancer

Human Genome Epidemiology (HuGE) Navigator: GNB4 (2 documents)

Export disorders for GNB4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GNB4 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with GNB4)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit. (PubMed id 11842130)^{1, 2, 3, 9} Ruiz-Velasco V....Puhl H.L. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The G protein subunit gene families. (PubMed id 10644457)^{1, 3} Downes G.B. and Gautam N. (1999)
Characterization of intron-1 haplotypes of the G protein beta 4 subunit gene--association with survival and progression in patients with urothelial bladder carcinoma. (PubMed id 18815590)^{1, 9} Riemann K....Siffert W. (2008)
The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. (PubMed id 12782285)^{1, 9} Rosskopf D....Siffert W. (2003)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)¹ Al-Hakim A.K....Pelletier L. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 59345	HGNC: 20731	AceView: GNB4	Ensembl:ENSG00000114450	euGenes: HUgn59345
ECgene: GNB4	Kegg: 59345	H-InvDB: GNB4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNB4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNB4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GNB4 gene:
Search GeneIP for patents involving GNB4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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