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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB3 Gene

protein-coding   GIFtS: 67
GCID: GC12P007109

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...
  See related diseases
at
MalaCards
 

Aliases
for GNB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 31 2     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 32
Transducin Beta Chain 32 3     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-32
G Protein, Beta-3 Subunit2     Hypertension Associated Protein2
GTP-Binding Regulatory Protein Beta-3 Chain2     

External Ids:    HGNC: 44001   Entrez Gene: 27842   Ensembl: ENSG000001116647   OMIM: 1391305   UniProtKB: P165203   

Export aliases for GNB3 gene to outside databases

Previous GC identifers: GC12M007019 GC12M007103 GC12P006828 GC12P006819 GC12P006977 GC12P006981 GC12P006808 GC12P006989 GC12P007001 GC12P007010 GC12P007021 GC12P007045


Summaries
for GNB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNB3 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this
gene is associated with essential hypertension and obesity. This polymorphism is also associated with the
occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of
alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional
splice variants may exist for this gene, but they have not been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB3 Gene: 
GNB3 (guanine nucleotide binding protein (G protein), beta polypeptide 3) is a protein-coding gene. Diseases associated with GNB3 include essential hypertension, and syncope, and among its related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway. GO annotations related to this gene include GTPase binding and GTPase activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB3 Gene


Genomic Views
for GNB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB3 gene promoter:
         GATA-2   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   HSF2   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

GNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007109:  view genomic region     (about GC identifiers)

Start:
 6,949,118 bp from pter      End:
 6,956,557 bp from pter
Size:
 7,440 bases      Orientation:
 plus strand

Proteins
for GNB3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3  
Size: 340 amino acids; 37221 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2
Secondary accessions: Q9BQC0

Explore the universe of human proteins at neXtProt for GNB3: NX_P16520

Explore proteomics data for GNB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16520

    • GNB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNB3 Protein Expression
    REFSEQ proteins: NP_002066.1  
    ENSEMBL proteins: 
     ENSP00000229264   ENSP00000442002   ENSP00000439753   ENSP00000414734   ENSP00000444325  
     ENSP00000445967  
    Reactome Protein details: P16520
    Human Recombinant Protein Products for GNB3: 
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    OriGene Protein Over-expression Lysate for GNB3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GNB3
    GenScript Custom Purified and Recombinant Proteins Services for GNB3
    Novus Biologicals GNB3 Proteins
    Novus Biologicals GNB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0043005neuron projection IEA--
    GO:0044297cell body IEA--

    GNB3 for ontologies           About GeneDecksing



    GNB3 Antibody Products: 
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    Assay Products for GNB3: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for GNB3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P16520

    ProtoNet protein and cluster: P16520

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    GNB3 for domains           About GeneDecksing


    Function
    for GNB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB3_HUMAN, P16520
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB3:
    guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s
    associated with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9425898
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----
    GO:0051020GTPase binding IPI19255495
         
    GNB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GNB3:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gnb3):
     mortality/aging  nervous system  vision/eye 

    GNB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gnb3tm1(KOMP)Vlcg for GNB3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNB3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNB3 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNB3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNB3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GNB3
    Sirion Biotech Customized adenovirus for overexpression of GNB3

    Clone
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    OriGene clones in human, mouse for GNB3 (see all 15)
    OriGene ORF clones in mouse, rat for GNB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB3
    Sirion Biotech Customized lentivirus for stable overexpression of GNB3 
                         Customized lentivirus expression plasmids for stable overexpression of GNB3 

    Cell Line
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    Search LifeMap BioReagents cell lines for GNB3
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3


    Pathways & Interactions
    for GNB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNB3 About   (see all 68)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Prostacyclin signalling through prostacyclin receptor
    		G-protein beta:gamma signalling0.89
    		Activation of Kainate Receptors upon glutamate binding0.70
    		G beta:gamma signalling through PI3Kgamma0.89
    		Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.61
    		Prostacyclin signalling through prostacyclin receptor0.77
    		Glucagon-type ligand receptors0.58
    		G beta:gamma signalling through PLC beta0.77
    		G-Protein Signaling through Tubby Protein0.38
    2fMLP Pathway
    		CCR3 Pathway in Eosinophils0.44
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Alpha-Adrenergic Signaling0.38
    		fMLP Pathway0.43
    		Signal transduction Calcium signaling0.34
    		Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    		Huntington's Disease Pathway0.30
    3Thromboxane signalling through TP receptor
    		Signal amplification0.78
    		Thrombin signalling through proteinase activated receptors (PARs)0.67
    		ADP signalling through P2Y purinoceptor 10.78
    		Development Angiotensin signaling via beta-Arrestin0.40
    		Thromboxane signalling through TP receptor0.78
    4Regulation of Water Balance by Renal Aquaporins
    		Regulation of Water Balance by Renal Aquaporins0.84
    		G alpha (z) signalling events0.49
    		Aquaporin-mediated transport0.84
    		Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    		Glucagon signaling in metabolic regulation0.69
    5Development Dopamine D2 receptor transactivation of EGFR
    		Development Dopamine D2 receptor transactivation of EGFR0.66
    		Apoptosis and survival BAD phosphorylation0.41
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		BAD Phosphorylation0.41
    		Chemotaxis CXCR4 signaling pathway0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNB3 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB3 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for GNB3
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/34 GeneGo (Thomson Reuters) Pathways for GNB3 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5 BioSystems Pathways for GNB3
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    Visual signal transduction- Cones

    5/48        Reactome Pathways for GNB3 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    2 PharmGKB Pathways for GNB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/12         Kegg Pathways  (Kegg details for GNB3) (see all 12):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/607 Interacting proteins for GNB3 (P165202, 3 ENSP000002292644) via UniProtKB, MINT, STRING, and/or I2D (see all 607)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG3P632153, ENSP000002941174I2D: score=2 STRING: ENSP00000294117
    GNG5P632183, ENSP000003596754I2D: score=2 STRING: ENSP00000359675
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GNG4P501503, ENSP000003555564I2D: score=2 STRING: ENSP00000355556
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS9425898
    GO:0007186G-protein coupled receptor signaling pathway TAS2107550
    GO:0007268synaptic transmission TAS--
    GO:0008217regulation of blood pressure TAS9425898

    GNB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/19 Novoseek inferred chemical compound relationships for GNB3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nppa 62.9 2 17036337 (1), 15699455 (1)
    sibutramine 56.7 6 20359253 (2), 19687782 (2)
    thiazide 46.9 2 16450155 (1)
    sodium 31.5 4 9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
    guanine 30.4 10 17065478 (2), 15171355 (1), 19301222 (1), 18325076 (1) (see all 5)
    clozapine 20.9 6 16141801 (2), 15179018 (1), 18855531 (1)
    clonidine 20.7 1 12844135 (1)
    hydrochlorothiazide 14.1 1 16450155 (1)
    cholesterol 8.22 4 10701813 (2), 11434508 (1), 15042113 (1)
    norepinephrine 7.47 3 16513451 (1), 17544870 (1), 17642146 (1)

    10/11 PharmGKB related drug/compound annotations for GNB3 gene (see all 11)    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    atorvastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    lovastatinCA  
    olanzapineCA  
    pravastatinCA  
    rosuvastatinCA  
    sildenafilCA  
    simvastatinCA  

    Search CenterWatch for drugs/clinical trials and news about GNB3 / GBB3

    Transcripts
    for GNB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNB3 gene: 
    NM_002075.2  

    Unigene Cluster for GNB3:

    Guanine nucleotide binding protein (G protein), beta polypeptide 3
    Hs.631657  [show with all ESTs]
    Unigene Representative Sequence: AB209283
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540458(uc001qrc.3) ENST00000229264(uc001qrd.3 uc009zfe.3)
    ENST00000541257 ENST00000541978 ENST00000435982 ENST00000539127 ENST00000542868
    ENST00000537035 ENST00000542751
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNB3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB3
    Clone
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    OriGene ORF clones in mouse, rat for GNB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB3
    Sirion Biotech Customized lentivirus for stable overexpression of GNB3 
                         Customized lentivirus expression plasmids for stable overexpression of GNB3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNB3

    Additional mRNA sequence: 

    AB209283.1 AB593098.1 AB593099.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 
    BT009800.1 M31328.1 U47930.1 

    9 DOTS entries:

    DT.121170390  DT.112163  DT.95155927  DT.121170335  DT.100779698  DT.40115198  DT.40265129  DT.95155920 
    DT.102841594 

    9 AceView cDNA sequences:

    U47931 NM_002075 BC015920 BC000115 BC002454 U47930 BT009800 M31328 
    AF501884 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -     -                                               -                     
    SP2:                                            -     -                                               -     -               
    SP3:                                            -     -                                               -                     
    SP4:                                            -     -                                                                     
    SP5:                                            -                                                                           


    ECgene alternative splicing isoforms for GNB3

    Expression
    for GNB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB3 expression in normal human tissues (normalized intensities)      GNB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTCCTT
    GNB3 Expression
    About this image


    GNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             seminal vesicle ; glandular cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See GNB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB3

    SOURCE GeneReport for Unigene cluster: Hs.631657
        SABiosciences Custom PCR Arrays for GNB3
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    Orthologs
    for GNB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNB3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gnb31 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 89.8(n)1
    97.06(a)1    		   6 (59.17 cM)5
    146951  NM_013530.11  NP_038558.11 
     1248342405 
    chicken
    (Gallus gallus)    		 Aves GNB31 guanine nucleotide binding protein (G protein), beta more 81.96(n)
    93.24(a)    		   427945  XM_425517.3  XP_425517.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GNB36
    		 Uncharacterized protein
    		 90(a)
    		 1 ↔ 1
    		 GL343453.1(391066-403708)
    zebrafish
    (Danio rerio)    		 Actinopterygii gnb3a1 guanine nucleotide binding protein (G protein), beta more 71.96(n)
    79.71(a)    		   436710  NM_001002437.1  NP_001002437.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta G&bgr;13F3 G-protein coupled receptor protein
    signaling pathway more    		 77(a)
    (best of 2)    		   13F16   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes STE46
    		 G protein beta subunit, forms a dimer with Ste18p ...
    		 32(a)
    		 1 → many
    		 XV(742910-744181)


    ENSEMBL Gene Tree for GNB3 (if available)
    TreeFam Gene Tree for GNB3 (if available)

    Paralogs
    for GNB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB3 gene
    GNB22  GNB12  WDR472  GNB52  GNB42  
    7 SIMAP similar genes for GNB3 using alignment to 8 protein entries:     GBB3_HUMAN (see all proteins):
    GNB1    GNB4    GNB2    GNB5    WDR61    PF20
    WDR82

    GNB3 for paralogs           About GeneDecksing



    Genomic Variants
    for GNB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/292 SNPs in GNB3 are shown (see all 292)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs454538001,2
    		C,F--6803600(+) TCTCTA/GTGGCC 1 -- int14Minor allele frequency- G:0.22WA CSA EA 242
    rs799912961,2
    		C--6803633(+) CCTCCC/AGGCTG 1 -- int12Minor allele frequency- A:0.14WA 120
    rs1931841601,2
    		--6803678(+) CCCTCC/TCCCCA 1 -- int10--------
    rs1468436601,2
    		--6878844(+) AGGGCC/TGCCTT 1 -- us2k10--------
    rs1397292731,2
    		--6878847(+) GCCGCC/GTTGAC 1 -- us2k10--------
    rs1905958831,2
    		C--6878879(+) TTCTGA/CGGTTT 1 -- us2k10--------
    rs1496863161,2
    		--6878916(+) TAGTAC/TGTATT 1 -- us2k10--------
    rs774106211,2
    		F--6878937(+) ATTGTA/GGGAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1833058231,2
    		--6878964(+) CCTAAA/TAGAAT 1 -- us2k10--------
    rs37593471,2
    		C,F,A,H--6878978(+) GCAGCG/ACCTGG 1 -- us2k117Minor allele frequency- A:0.29NS EA NA WA 2340

    HapMap Linkage Disequilibrium report for GNB3 (6949118 - 6956557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898641CNV Loss21882294
    dgv1353n71CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv898638CNV Loss21882294
    nsv832324CNV Loss17160897


    Human Gene Mutation Database (HGMD): GNB3
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for GNB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 139130   
    OMIM disorders: 145500  
    20/73 diseases for GNB3 (see all 73):    About MalaCards
    essential hypertension    syncope    aortic coarctation    seasonal affective disorder
    hypertension    dyspepsia    irritable bowel syndrome    carotid stenosis
    cluster headache    headache    thyroid adenoma    mood disorder
    tardive dyskinesia    obesity    gastroesophageal reflux disease    obesity, association with
    adrenal adenoma    cerebral palsy    major depressive disorder    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for GNB3:
    Hypertension

    GNB3 for disorders           About GeneDecksing

    10/31 Novoseek inferred disease relationships for GNB3 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 79.1 39 10817859 (2), 19811352 (2), 15042113 (2), 17278960 (1) (see all 28)
    obesity 60.9 59 15090636 (3), 12730030 (3), 19065529 (2), 19594364 (2) (see all 30)
    genetic susceptibility 53.9 1 10713907 (1)
    hypertension arterial 52 8 11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see all 6)
    ventricular hypertrophy 41.1 2 12011775 (1), 15332573 (1)
    thyroid adenoma 38.5 1 17136758 (1)
    major depression 32.3 10 14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see all 7)
    insulin resistance 31.9 10 12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see all 6)
    mood disorders 28 3 11586049 (2), 11992559 (1)
    schizophrenia 26.5 4 16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)

    Genetic Association Database (GAD): GNB3
    Human Genome Epidemiology (HuGE) Navigator: GNB3 (294 documents)

    Export disorders for GNB3 gene to outside databases

    Publications
    for GNB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB3 gene, integrated from 9 sources (see all 410):
    (articles sorted by number of sources associating them with GNB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. (PubMed id 11927836)1, 4, 9 Rosskopf D....Siffert W. (2002)
    2. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. (PubMed id 17717746)1, 4, 9 Tahara T....Nakano H. (2008)
    3. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. (PubMed id 16908025)1, 4, 9 Renner W....Marz W. (2007)
    4. The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160)1, 4, 9 Krippl P....Samonigg H. (2004)
    5. GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. (PubMed id 15042113)1, 4, 9 Wang X....Wen H. (2004)
    6. G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009)1, 2, 9 Rosskopf D.... Siffert W. (2000)
    7. [Association of alpha-adducin gene and G-protein beta3-subuint gene with essential hypertension in Chinese] (PubMed id 17825147)1, 4, 9 Huang X.H....Hui R.T. (2007)
    8. [Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity] (PubMed id 12930636)1, 4, 9 Chen Y.Y....Hui R.T. (2003)
    9. A Preliminary Candidate Genotype-Intermediate Phenoty pe Study of Satiation and Gastric Motor Function in Obesity. (PubMed id 19876010)1, 4, 9 Papathanasopoulos A....Zinsmeister A.R. (2009)
    10. [Analysis of the GNB3 gene 825C/T polymorphism in non-obese and obese Chinese.] (PubMed id 19065529)1, 4, 9 Wang X....Liu B. (2008)

    External Searches for GNB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GNB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2784 HGNC: 4400 AceView: GNB3 Ensembl:ENSG00000111664 euGenes: HUgn2784
    ECgene: GNB3 Kegg: 2784 H-InvDB: GNB3

    Other Databases showing GNB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNB3 gene:
    Search GeneIP for patents involving GNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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