GNB3 Gene
protein-coding GIFtS : 67 GCID: GC12 P007109
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...
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Aliasesfor GNB3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 3 1 2 Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 32 Transducin Beta Chain 32 3 Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-32 G Protein, Beta-3 Subunit2 Hypertension Associated Protein2 GTP-Binding Regulatory Protein Beta-3 Chain2
Export aliases for GNB3 gene to outside databases Previous GC identifers: GC12M007019 GC12M007103 GC12P006828 GC12P006819 GC12P006977 GC12P006981 GC12P006808 GC12P006989 GC12P007001 GC12P007010 GC12P007021 GC12P007045
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Summariesfor GNB3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for GNB3 Gene: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. (provided by RefSeq, Jul 2008) GeneCards Summary for GNB3 Gene: GNB3 (guanine nucleotide binding protein (G protein), beta polypeptide 3) is a protein-coding gene. Diseases associated with GNB3 include essential hypertension syncope related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway . GO annotations related to this gene include GTPase binding and GTPase activity . An important paralog of this gene is GNB2 . UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 Function : Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction summary
for GNB3 Gene: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G proteincontains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor bindingresults in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation ofsecond messenger signalling cascades. There are several types of Galpha proteins; in addition, someGbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 andGbetagamma coupled to M1 receptors can activate KIR channels. Gene Wiki entry for GNB3 Gene
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Genomic Viewsfor GNB3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NT_009759.16 NC_018923.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GNB3 gene promoter:GATA-2 CREB PPAR-alpha PPAR-gamma1 deltaCREB HSF2 PPAR-gamma2 ATF Other transcription factors Search SABiosciences Chromatin IP Primers for GNB3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13 GNB3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P007109: view genomic region
(about GC identifiers )
Start: 6,949,118 bp from pter End:
6,956,557 bp from pter
Size: 7,440 bases Orientation:
plus strand
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Proteinsfor GNB3 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 See
protein sequence )Recommended Name: Size : 340 amino acids; 37221 DaSubunit : G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2Secondary accessions : Q9BQC0Explore the universe of human proteins at neXtProt for GNB3: NX_P16520 Explore proteomics data for GNB3 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P16520 GNB3 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_002066.1 ENSEMBL proteins: ENSP00000229264 ENSP00000442002 ENSP00000439753 ENSP00000414734 ENSP00000444325 ENSP00000445967 Reactome Protein details: P16520 Human Recombinant Protein Products for GNB3: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing GNB3 Antibody Products: Assay Products for GNB3:
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Protein
Domains /for GNB3 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: WDR: WD repeat domain containing 5/7 InterPro protein domains (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P16520 ProtoNet protein and cluster: P16520
2 Blocks protein domains : IPB001632 IPB001680 UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 Similarity : Belongs to the WD repeat G protein beta familySimilarity : Contains 7 WD repeatsAbout GeneDecksing
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Functionfor GNB3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: GBB3_HUMAN, P16520 Function : Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Genatlas biochemistry entry for GNB3 guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s associated with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for GNB3 :3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnb3) :About GeneDecksing Animal Models: Gnb3 tm1(KOMP)Vlcg for GNB3In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3
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Pathways & Interactionsfor GNB3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for GNB3 About (see all 68 ) See pathways by source SuperPath Selected contained pathways About (see all per SuperPath ) 1 Prostacyclin signalling through prostacyclin receptor 2 fMLP Pathway 3 Thromboxane signalling through TP receptor 4 Regulation of Water Balance by Renal Aquaporins 5 Development Dopamine D2 receptor transactivation of EGFR
Pathways by source See SuperPaths Show all pathways 5/31 (see all 31 )5/71 (see all 71 )2 5/34 (see all 34 )5 5/48 (see all 48 )2 GNB3 5/12 (Kegg details for GNB3) (see all 12 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/607 Interacting proteins for GNB3 (P16520 2 , 3 ENSP00000229264 4 via UniProtKB, MINT, STRING , and/or I2D (see all 607 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing
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Drugs & Compoundsfor GNB3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for GNB3 available from Tocris Bioscience About this table 3 HMDB Compounds for GNB3 About this table 10/19 Novoseek inferred chemical compound relationships for GNB3 gene (see all 19 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
nppa
62.9
2
17036337 (1), 15699455 (1)
sibutramine
56.7
6
20359253 (2), 19687782 (2)
thiazide
46.9
2
16450155 (1)
sodium
31.5
4
9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
guanine
30.4
10
17065478 (2), 15171355 (1), 19301222 (1), 18325076 (1) (see
all 5 )
clozapine
20.9
6
16141801 (2), 15179018 (1), 18855531 (1)
clonidine
20.7
1
12844135 (1)
hydrochlorothiazide
14.1
1
16450155 (1)
cholesterol
8.22
4
10701813 (2), 11434508 (1), 15042113 (1)
norepinephrine
7.47
3
16513451 (1), 17544870 (1), 17642146 (1)
10/11 PharmGKB related drug/compound annotations for GNB3 gene (see all 11 ) About this table GNB3 / GBB3
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Transcriptsfor GNB3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for GNB3 gene: NM_002075.2 Unigene Cluster for GNB3:
Guanine nucleotide binding protein (G protein), beta polypeptide 3 Hs.631657 [show with all ESTs ] Unigene Representative Sequence: AB209283 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000540458 (uc001qrc.3 ) ENST00000229264 (uc001qrd.3 uc009zfe.3 )ENST00000541257 ENST00000541978 ENST00000435982 ENST00000539127 ENST00000542868 ENST00000537035 ENST00000542751 Primer GNB3 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB209283.1 AB593098.1 AB593099.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 BT009800.1 M31328.1 U47930.1
9 DOTS entries : DT.121170390 DT.112163
DT.95155927 DT.121170335 DT.100779698 DT.40115198 DT.40265129 DT.95155920 DT.102841594 9 AceView cDNA sequences :
U47931 NM_002075 BC015920 BC000115 BC002454 U47930 BT009800 M31328 AF501884 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 SP1 : - - - SP2 : - - - - SP3 : - - - SP4 : - - SP5 : -
ECgene alternative splicing isoforms for GNB3
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Expression for GNB3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GNB3 expression in normal human tissues
(normalized intensities) GNB3 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CTTTCTCCTTAbout this image
GNB3 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/12 selected tissues (see all 12 ) fully expand See GNB3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for GNB3 SOURCE GeneReport for Unigene cluster: Hs.631657 SABiosciences Custom PCR Arrays for GNB3 Primer GNB3 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3
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Orthologsfor GNB3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for GNB3 gene from 6/13 species (see all 13 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Gnb31 5
guanine nucleotide binding protein (G protein), beta more 1, 5
89.8(n) 1 97.06(a) 1
6 (59.17 cM) 5 14695 1 NM_013530.1 1 NP_038558.1 1 124834240 5
chicken Aves GNB31
guanine nucleotide binding protein (G protein), beta more
81.96(n) 93.24(a)
427945 XM_425517.3 XP_425517.3
lizard Reptilia GNB36
Uncharacterized protein
90(a)
1 ↔ 1
GL343453.1(391066-403708)
zebrafish Actinopterygii gnb3a1
guanine nucleotide binding protein (G protein), beta more
71.96(n) 79.71(a)
436710 NM_001002437.1 NP_001002437.1
fruit fly Insecta G&bgr;13F3
G-protein coupled receptor protein signalingmore
77(a)
13F16 --
baker's yeast Saccharomycetes STE46
G protein beta subunit, forms a dimer with Ste18p ... 32(a)
1 → many
XV(742910-744181)
ENSEMBL Gene Tree for GNB3 (if available)TreeFam Gene Tree for GNB3 (if available)
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Paralogsfor GNB3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for GNB3 gene GNB2 2 GNB1 2 WDR47 2 GNB5 2 GNB4 2 7 SIMAP similar genes for GNB3 using alignment to 8 protein entries: GBB3_HUMAN (see all proteins ):GNB1 GNB4 GNB2 GNB5 WDR61 PF20 WDR82 About GeneDecksing
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Genomic Variantsfor GNB3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for GNB3 (6949118 - 6956557 bp)
Structural Variations Database of Genomic Variants (DGV) 5 variations for GNB3 : About this table Human Gene Mutation Database (HGMD) : GNB3 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor GNB3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 139130 OMIM disorders : 145500 20/73 (see all 73 ): About MalaCards essential hypertension syncope aortic coarctation seasonal affective disorder hypertension dyspepsia irritable bowel syndrome carotid stenosis cluster headache headache thyroid adenoma mood disorder tardive dyskinesia obesity gastroesophageal reflux disease obesity, association with adrenal adenoma cerebral palsy major depressive disorder bipolar disorder 1 disease from the University of Copenhagen DISEASES database for GNB3 :Hypertension 10/31 Novoseek inferred disease relationships for GNB3 gene (see all 31 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension
79.1
39
10817859 (2), 19811352 (2), 15042113 (2), 17278960 (1) (see
all 28 )
obesity
60.9
59
15090636 (3), 12730030 (3), 19065529 (2), 19594364 (2) (see
all 30 )
genetic susceptibility
53.9
1
10713907 (1)
hypertension arterial
52
8
11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see
all 6 )
ventricular hypertrophy
41.1
2
12011775 (1), 15332573 (1)
thyroid adenoma
38.5
1
17136758 (1)
major depression
32.3
10
14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see
all 7 )
insulin resistance
31.9
10
12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see
all 6 )
mood disorders
28
3
11586049 (2), 11992559 (1)
schizophrenia
26.5
4
16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)
Genetic Association Database (GAD): GNB3 Human Genome Epidemiology (HuGE) Navigator: GNB3 (294 documents) Export disorders for GNB3 gene to outside databases
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Publicationsfor GNB3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for GNB3 gene, integrated from 9 sources (see all 410 ):(articles sorted by number of sources associating them with GNB3) Utopia : connect your pdf to the dynamic
Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. (PubMed id 11927836) 1 , 4, 9(2002) Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. (PubMed id 17717746) 1 , 4, 9(2008) G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. (PubMed id 16908025) 1 , 4, 9(2007) The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160) 1 , 4, 9(2004) GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. (PubMed id 15042113) 1 , 4, 9(2004) G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009) 1 , 2 , 9(2000) [Association of alpha-adducin gene and G-protein beta3-subuint gene with essential hypertension in Chinese] (PubMed id 17825147) 1 , 4, 9(2007) [Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity] (PubMed id 12930636) 1 , 4, 9(2003) A Preliminary Candidate Genotype-Intermediate Phenoty pe Study of Satiation and Gastric Motor Function in Obesity. (PubMed id 19876010) 1 , 4, 9(2009) [Analysis of the GNB3 gene 825C/T polymorphism in non-obese and obese Chinese.] (PubMed id 19065529) 1 , 4, 9(2008)
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External Searches for GNB3 gene
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Genome Databases showing GNB3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing GNB3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for GNB3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for GNB3 gene: GNB3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GNB3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNB3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for GNB3
Tocris compounds for GNB3
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3
ThermoFisher Antibodies for GNB3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GNB3
LSBio Antibodies in human mouse rat
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summary
for 
GeneGo (Thomson Reuters) Pathways for GNB3 (
BioSystems Pathways for GNB3
PharmGKB Pathways for 
Kegg Pathways 
