Aliases for GNB3 Gene
Aliases for GNB3 Gene
- G Protein Subunit Beta 3 2 3 5
- Transducin Beta Chain 3 2 3 4
- Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 3 2 3
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3 3
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3 3
- GTP-Binding Regulatory Protein Beta-3 Chain 3
- Hypertension Associated Protein 3
- G Protein, Beta-3 Subunit 3
- CSNB1H 3
External Ids for GNB3 Gene
- HGNC: 4400
- Entrez Gene: 2784
- Ensembl: ENSG00000111664
- OMIM: 139130
- UniProtKB: P16520
Previous GeneCards Identifiers for GNB3 Gene
- GC12M007019
- GC12M007103
- GC12P006828
- GC12P006819
- GC12P006977
- GC12P006981
- GC12P006808
- GC12P006989
- GC12P007001
- GC12P007010
- GC12P007021
- GC12P007045
- GC12P007109
- GC12P007133
Summaries for GNB3 Gene
-
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
GeneCards Summary for GNB3 Gene
GNB3 (G Protein Subunit Beta 3) is a Protein Coding gene. Diseases associated with GNB3 include Congenital Stationary Night Blindness 1H and Hypertension, Essential. Among its related pathways are CCR5 Pathway in Macrophages and Aquaporin-mediated transport. GO annotations related to this gene include GTPase activity and spectrin binding. An important paralog of this gene is GNB1.
UniProtKB/Swiss-Prot for GNB3 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNB3 Gene
Genomics for GNB3 Gene
Regulatory Elements for GNB3 Gene
Enhancers for GNB3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GNB3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GNB3 gene promoter:
Regulatory Element Products
Genomic Location for GNB3 Gene
- Chromosome:
- 12
- Start:
- 6,839,954 bp from pter
- End:
- 6,847,395 bp from pter
- Size:
- 7,442 bases
- Orientation:
- Plus strand
Genomic View for GNB3 Gene
Genes around GNB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
GNB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNB3 Gene
Proteins for GNB3 Gene
-
Protein details for GNB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16520-GBB3_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
- Protein Accession:
- P16520
- Q96B71
- Q9BQC0
Protein attributes for GNB3 Gene
- Size:
- 340 amino acids
- Molecular mass:
- 37221 Da
- Quaternary structure:
-
- G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2.
Protein Expression for GNB3 Gene
Post-translational modifications for GNB3 Gene
Other Protein References for GNB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for GNB3 (G-beta 3)
-
Custom Antibody ServicesOriGene Antibodies for GNB3
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- Invitrogen Antibodies for GNB3
- antibodies-online Antibodies for GNB3: See all 68
- GeneTex GNB3 antibody for GNB3
Protein Products
-
OriGene Purified Proteins for GNB3
- Search Origene for MassSpec and Protein Over-expression Lysates for GNB3
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- ProSpec Recombinant Proteins for GNB3
-
Cloud-Clone Corp. Proteins for GNB3
- antibodies-online Proteins for GNB3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GNB3
No data available for DME Specific Peptides for GNB3 Gene
Domains & Families for GNB3 Gene
Gene Families for GNB3 Gene
Protein Domains for GNB3 Gene
Suggested Antigen Peptide Sequences for GNB3 Gene
Graphical View of Domain Structure for InterPro Entry
P16520- Family:
-
- Belongs to the WD repeat G protein beta family.
Function for GNB3 Gene
Molecular function for GNB3 Gene
- GENATLAS Biochemistry:
- guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s associated with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | 9425898 |
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 23773523 |
| GO:0030507 | spectrin binding | IEA | -- |
| GO:0051020 | GTPase binding | IPI | 19255495 |
Phenotypes for GNB3 Gene
- MGI mutant phenotypes for GNB3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GNB3:
Animal Models for GNB3 Gene
- MGI Knock Outs for GNB3:
-
- Gnb3 tm1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GNB3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GNB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GNB3 gene
- Search ViGene Biosciences for GNB3
CRISPR Products
-
OriGene CRISPR knockouts for GNB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNB3
- GenScript: Design CRISPR guide RNA sequences for GNB3
miRNA for GNB3 Gene
- miRTarBase miRNAs that target GNB3
miRNA Products
- Search ViGene Biosciences for GNB3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for GNB3
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-
ViGene Biosciences ready-to-package AAV shRNAs for GNB3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for GNB3
- VectorBuilder custom plasmid, inducible vectors for GNB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GNB3
-
ViGene Biosciences adenoviral particle packaged cDNA for GNB3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GNB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GNB3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNB3 Gene
Localization for GNB3 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0030425 | dendrite | IEA | -- |
| GO:0043005 | neuron projection | IEA | -- |
| GO:0044297 | cell body | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNB3 Gene
Pathways & Interactions for GNB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Angiotensin activation of ERK | ||
| 2 | ADP signalling through P2Y purinoceptor 12 | ||
| 3 | fMLP Pathway |
.43
|
.39
|
| 4 | Presynaptic function of Kainate receptors | ||
| 5 | Development Dopamine D2 receptor transactivation of EGFR | ||
Pathways by source for GNB3 Gene
2 Cell Signaling Technology pathways for GNB3 Gene
6 BioSystems pathways for GNB3 Gene
58 Reactome pathways for GNB3 Gene
2 PharmGKB pathways for GNB3 Gene
15 KEGG pathways for GNB3 Gene
34 GeneGo (Thomson Reuters) pathways for GNB3 Gene
Interacting Proteins for GNB3 Gene
Selected Interacting proteins:
ENSP00000229264
P16520-GBB3_HUMAN
for GNB3 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | 2107550 |
| GO:0008217 | regulation of blood pressure | TAS | 9425898 |
| GO:0071377 | cellular response to glucagon stimulus | TAS | -- |
Drugs & Compounds for GNB3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Clonidine | Approved | Pharma | Partial agonist, Agonist | 240 | ||
| Atenolol | Approved | Pharma | Antagonist | 104 | ||
| Bumetanide | Approved | Pharma | Agonist | NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor | 17 | |
| Furosemide | Approved, Vet_approved | Pharma | Agonist | GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA | 193 | |
| Hydralazine | Approved | Pharma | 45 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 8-Bromo-cGMP, sodium salt |
|
51116-01-9 |
|
|
||
| CMPD101 |
|
865608-11-3 |
|
|
||
| Gallein |
|
2103-64-2 |
|
|
||
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
||
| Pertussis Toxin |
|
70323-44-3 |
|
|
(5) Tocris Compounds for GNB3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 8-Bromo-cGMP, sodium salt | cGMP analog; activates PKG | 51116-01-9 |
| CMPD101 | Potent and selective GRK2/3 inhibitor | 865608-11-3 |
| Gallein | Inhibitor of betagamma signaling | 2103-64-2 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Pertussis Toxin | Catalyzes ADP-ribosylation of Gi, Go and Gt | 70323-44-3 |
Transcripts for GNB3 Gene
mRNA/cDNA for GNB3 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GNB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GNB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNB3
- GenScript: Design CRISPR guide RNA sequences for GNB3
miRNA Products
- Search ViGene Biosciences for GNB3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for GNB3
- Browse OriGene Inhibitory RNA Products For GNB3
-
ViGene Biosciences ready-to-package AAV shRNAs for GNB3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for GNB3
- VectorBuilder custom plasmid, inducible vectors for GNB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for GNB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Neurons
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
-
Eye (Sensory Organs)
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for GNB3 Gene
This gene is overexpressed in Pituitary (x8.6), Brain - Cerebellum (x5.7), and Brain - Cerebellar Hemisphere (x4.9).
This gene is overexpressed in Retina (60.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of GNB3 Gene:
GNB3SOURCE GeneReport for Unigene cluster for GNB3 Gene:
Hs.631657Evidence on tissue expression from TISSUES for GNB3 Gene
- Eye(4.9)
- Nervous system(4.3)
- Blood(2.4)
Primer Products
-
OriGene qPCR primer pairs for GNB3
-
OriGene qPCR primer pairs and template standards for GNB3
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNB3 Gene
Orthologs for GNB3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNB3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GNB3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GNB3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GNB3 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Gnb3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gnb3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GNB3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GNB3 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GNB3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gnb3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gnb3a 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Gbgr13F 36 |
|
|
|
| Gbeta13F 35 |
|
OneToMany | |||
| Gbgr76C 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | gpb-1 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10536 35 |
|
OneToMany |
- Species where no ortholog for GNB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GNB3 Gene
(7) SIMAP similar genes for GNB3 Gene using alignment to 8 proteins:
Variants for GNB3 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs140263599 | Pathogenic, Night blindness, congenital stationary, 1H (CSNB1H) [MIM:617024] | 6,843,073(+) | TGATT(C/T)TAAGT | reference, missense | |
| rs5443 | drug-response | 6,845,711(+) | ACGTC(C/T)GTGGC | nc-transcript-variant, reference, synonymous-codon | |
| rs879253773 | Pathogenic | 6,846,892(+) | ATCTG(A/G)AACTG | nc-transcript-variant, reference, missense, utr-variant-3-prime, stop-gained | |
| rs879253774 | Pathogenic | 6,843,043(+) | GGCCA(-/AGA)TTTAC | cds-indel | |
| rs1001237782 | -- | 6,847,183(+) | GCAGG(A/C)CCAGC | intron-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.95;
49.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GNB3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB3 Gene
Disorders for GNB3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital stationary night blindness 1h |
|
|
| hypertension, essential |
|
|
| dyspepsia |
|
|
| peripartum cardiomyopathy |
|
|
| syncope |
|
|
Search GNB3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GBB3_HUMAN- Night blindness, congenital stationary, 1H (CSNB1H) [MIM:617024]: A form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision or in dim light, with good vision only on bright days. CSNB1H patients present with childhood-onset night blindness and middle age-onset photophobia, but have near-normal vision and do not exhibit nystagmus or high myopia. CSNB1H inheritance is autosomal recessive. {ECO:0000269 PubMed:27063057}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for GNB3
No data available for Genatlas for GNB3 Gene
Publications for GNB3 Gene
- A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PMID: 19876010) Papathanasopoulos A. … Zinsmeister A.R. (Obesity (Silver Spring) 2010) 3 22 46 64
- Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. (PMID: 20235788) Filigheddu F. … Glorioso N. (Pharmacogenomics 2010) 3 22 46 64
- Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population. (PMID: 20359253) Hsiao T.J. … Lin E. (Mol Diagn Ther 2010) 3 22 46 64
- The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication. (PMID: 19145770) Plat A.W. … Kroon A.A. (J. Hypertens. 2009) 3 22 46 64
- Genetic insight into syncopal tilted population with severe clinical presentation. (PMID: 19243996) Lelonek M. … Goch J.H. (Auton Neurosci 2009) 3 22 46 64
Products for GNB3 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GNB3
- VectorBuilder custom plasmid, inducible vectors for GNB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GNB3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GNB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer