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GNB3 Gene

protein-coding   GIFtS: 67
GCID: GC12P007133

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 31 2     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 32
Transducin Beta Chain 32 3     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-32
G Protein, Beta-3 Subunit2     Hypertension Associated Protein2
GTP-Binding Regulatory Protein Beta-3 Chain2     

External Ids:    HGNC: 44001   Entrez Gene: 27842   Ensembl: ENSG000001116647   OMIM: 1391305   UniProtKB: P165203   

Export aliases for GNB3 gene to outside databases

Previous GC identifers: GC12M007019 GC12M007103 GC12P006828 GC12P006819 GC12P006977 GC12P006981 GC12P006808 GC12P006989 GC12P007001 GC12P007010 GC12P007021 GC12P007045 GC12P007109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNB3 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this
gene is associated with essential hypertension and obesity. This polymorphism is also associated with the
occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of
alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional
splice variants may exist for this gene, but they have not been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB3 Gene:
GNB3 (guanine nucleotide binding protein (G protein), beta polypeptide 3) is a protein-coding gene. Diseases associated with GNB3 include syncope, and aortic coarctation. GO annotations related to this gene include GTPase binding and signal transducer activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNB3 gene promoter:
         GATA-2   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   HSF2   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNB3 promoter sequence
   Search Chromatin IP Primers for GNB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

GNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007133:  view genomic region     (about GC identifiers)

Start:
6,949,118 bp from pter      End:
6,956,557 bp from pter
Size:
7,440 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3  
Size: 340 amino acids; 37221 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2
Secondary accessions: Q9BQC0

Explore the universe of human proteins at neXtProt for GNB3: NX_P16520

Explore proteomics data for GNB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002066.1  
    ENSEMBL proteins: 
     ENSP00000229264   ENSP00000442002   ENSP00000439753   ENSP00000414734   ENSP00000444325  
     ENSP00000445967  
    Reactome Protein details: P16520

    GNB3 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    GNB3 Antibody Products:

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    GNB3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P16520

    ProtoNet protein and cluster: P16520

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    GNB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB3_HUMAN, P16520
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB3:
    guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s
    associated with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9425898
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
    GO:0051020GTPase binding IPI19255495
         
    GNB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GNB3:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnb3):
     mortality/aging  nervous system  vision/eye 

    GNB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gnb3tm1(KOMP)Vlcg for GNB3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNB3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNB3

    miRNA
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    miRTarBase miRNAs that target GNB3:
    hsa-mir-26b-5p (MIRT029954)

    Block miRNA regulation of human, mouse, rat GNB3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNB3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0043005neuron projection IEA--
    GO:0044297cell body IEA--

    GNB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNB3 About   (see all 72)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNB3 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for GNB3
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for GNB3 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for GNB3 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone

    Selected Reactome Pathways for GNB3 (see all 23)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    2 PharmGKB Pathways for GNB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNB3) (see all 13):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling


    GNB3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNB3
    Interactions:

        GeneGlobe Interaction Network for GNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNB3 (P165202, 3 ENSP000002292644) via UniProtKB, MINT, STRING, and/or I2D (see all 683)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG3P632153, ENSP000002941174I2D: score=2 STRING: ENSP00000294117
    GNG4P501503, ENSP000003555564I2D: score=2 STRING: ENSP00000355556
    GNG5P632183, ENSP000003596754I2D: score=2 STRING: ENSP00000359675
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GNG7O602623, ENSP000003715944I2D: score=2 STRING: ENSP00000371594
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS9425898
    GO:0007186G-protein coupled receptor signaling pathway TAS2107550
    GO:0007268synaptic transmission TAS--
    GO:0008217regulation of blood pressure TAS9425898

    GNB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GNB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for GNB3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nppa 62.9 2 17036337 (1), 15699455 (1)
    sibutramine 56.7 6 20359253 (2), 19687782 (2)
    thiazide 46.9 2 16450155 (1)
    sodium 31.5 4 9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
    guanine 30.4 10 17065478 (2), 15171355 (1), 19301222 (1), 18325076 (1) (see all 5)
    clozapine 20.9 6 16141801 (2), 15179018 (1), 18855531 (1)
    clonidine 20.7 1 12844135 (1)
    hydrochlorothiazide 14.1 1 16450155 (1)
    cholesterol 8.22 4 10701813 (2), 11434508 (1), 15042113 (1)
    norepinephrine 7.47 3 16513451 (1), 17544870 (1), 17642146 (1)

    Selected PharmGKB related drug/compound annotations for GNB3 gene (see all 11)    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    atorvastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    lovastatinCA  
    olanzapineCA  
    pravastatinCA  
    rosuvastatinCA  
    sildenafilCA  
    simvastatinCA  



    GNB3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GNB3 gene: 
    NM_002075.2  

    Unigene Cluster for GNB3:

    Guanine nucleotide binding protein (G protein), beta polypeptide 3
    Hs.631657  [show with all ESTs]
    Unigene Representative Sequence: AB209283
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540458(uc001qrc.3) ENST00000229264(uc001qrd.3 uc009zfe.3)
    ENST00000541257 ENST00000541978 ENST00000435982 ENST00000539127 ENST00000542868
    ENST00000537035 ENST00000542751
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    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNB3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB3
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      QuantiFast Probe-based Assays in human, mouse, rat GNB3

    Additional mRNA sequence: 

    AB209283.1 AB593098.1 AB593099.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 
    BT009800.1 M31328.1 U47930.1 

    9 DOTS entries:

    DT.121170390  DT.112163  DT.95155927  DT.121170335  DT.100779698  DT.40115198  DT.40265129  DT.95155920 
    DT.102841594 

    9 AceView cDNA sequences:

    NM_002075 U47931 U47930 BC002454 BC000115 BC015920 AF501884 M31328 
    BT009800 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -     -                                               -                     
    SP2:                                            -     -                                               -     -               
    SP3:                                            -     -                                               -                     
    SP4:                                            -     -                                                                     
    SP5:                                            -                                                                           


    ECgene alternative splicing isoforms for GNB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTCCTT
    GNB3 Expression
    About this image


    GNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
             Oviduct
    GNB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631657
        Custom PCR Arrays for GNB3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNB3
    OriGene qSTAR qPCR primer pairs in human, mouse for GNB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB3
    QuantiTect SYBR Green Assays in human, mouse, rat GNB3
    QuantiFast Probe-based Assays in human, mouse, rat GNB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GNB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb31 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 89.8(n)1
    97.06(a)1
      6 (59.17 cM)5
    146951  NM_013530.11  NP_038558.11 
     1248342405 
    chicken
    (Gallus gallus)
    Aves GNB31 guanine nucleotide binding protein (G protein), beta more 81.96(n)
    93.24(a)
      427945  XM_004938118.1  XP_004938175.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNB36
    guanine nucleotide binding protein (G protein), be...
    90(a)
    1 ↔ 1
    GL343453.1(391066-403708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gnb31 guanine nucleotide binding protein (G protein), beta more 77.55(n)
    88.24(a)
      496520  NM_001011107.1  NP_001011107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gnb3a1 guanine nucleotide binding protein (G protein), beta more 71.96(n)
    79.71(a)
      436710  NM_001002437.1  NP_001002437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;13F3 G-protein coupled receptor protein
    signaling pathway more
    77(a)
    (best of 2)
      13F16   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-13 guanine nucleotide-binding protein beta
    subunit
    81(a)   II(11743881-11747549)   --


    ENSEMBL Gene Tree for GNB3 (if available)
    TreeFam Gene Tree for GNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNB3 gene
    GNB22  GNB12  WDR472  GNB52  GNB42  
    7 SIMAP similar genes for GNB3 using alignment to 8 protein entries:     GBB3_HUMAN (see all proteins):
    GNB1    GNB4    GNB2    GNB5    WDR61    PF20
    WDR82

    GNB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNB3 (see all 292)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs454538001,2
    C,F--6803600(+) TCTCTA/GTGGCC 1 -- int14Minor allele frequency- G:0.22WA CSA EA 242
    rs799912961,2
    C--6803633(+) CCTCCC/AGGCTG 1 -- int12Minor allele frequency- A:0.14WA 120
    rs1931841601,2
    --6803678(+) CCCTCC/TCCCCA 1 -- int10--------
    rs1468436601,2
    --6878844(+) AGGGCC/TGCCTT 1 -- us2k10--------
    rs1397292731,2
    --6878847(+) GCCGCC/GTTGAC 1 -- us2k10--------
    rs1905958831,2
    C--6878879(+) TTCTGA/CGGTTT 1 -- us2k10--------
    rs1496863161,2
    --6878916(+) TAGTAC/TGTATT 1 -- us2k10--------
    rs774106211,2
    F--6878937(+) ATTGTA/GGGAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1833058231,2
    --6878964(+) CCTAAA/TAGAAT 1 -- us2k10--------
    rs37593471,2
    C,F,A,H--6878978(+) GCAGCG/ACCTGG 1 -- us2k117Minor allele frequency- A:0.29NS EA NA WA 2340

    HapMap Linkage Disequilibrium report for GNB3 (6949118 - 6956557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898641CNV Loss21882294
    dgv1353n71CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv898638CNV Loss21882294
    nsv832324CNV Loss17160897

    Human Gene Mutation Database (HGMD): GNB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for GNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139130   
    OMIM disorders: 145500  
    Selected diseases for GNB3 (see all 77):    
    About MalaCards
    syncope    aortic coarctation    essential hypertension    nephropathy-hypertension
    irritable bowel syndrome    dyspepsia    seasonal affective disorder    hypertension
    carotid stenosis    cluster headache    headache    thyroid adenoma
    mood disorder    tardive dyskinesia    adrenal adenoma    gastroesophageal reflux disease
    obesity    major depressive disorder    obesity, association with    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for GNB3:
    Hypertension

    GNB3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GNB3 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 79.1 39 10817859 (2), 19811352 (2), 15042113 (2), 17278960 (1) (see all 28)
    obesity 60.9 59 15090636 (3), 12730030 (3), 19065529 (2), 19594364 (2) (see all 30)
    genetic susceptibility 53.9 1 10713907 (1)
    hypertension arterial 52 8 11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see all 6)
    ventricular hypertrophy 41.1 2 12011775 (1), 15332573 (1)
    thyroid adenoma 38.5 1 17136758 (1)
    major depression 32.3 10 14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see all 7)
    insulin resistance 31.9 10 12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see all 6)
    mood disorders 28 3 11586049 (2), 11992559 (1)
    schizophrenia 26.5 4 16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)

    Genetic Association Database (GAD): GNB3
    Human Genome Epidemiology (HuGE) Navigator: GNB3 (294 documents)

    Export disorders for GNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNB3 gene, integrated from 10 sources (see all 415) (see top 10):
    (articles sorted by number of sources associating them with GNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. (PubMed id 11927836)1, 4, 9 Rosskopf D....Siffert W. (Pharmacogenetics 2002)
    2. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. (PubMed id 17717746)1, 4, 9 Tahara T....Nakano H. (Dig. Dis. Sci. 2008)
    3. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. (PubMed id 16908025)1, 4, 9 Renner W....MAorz W. (Atherosclerosis 2007)
    4. The 825C&gt;T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160)1, 4, 9 Krippl P....Samonigg H. (Cancer Lett. 2004)
    5. GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. (PubMed id 15042113)1, 4, 9 Wang X....Wen H. (J Hum Hypertens 2004)
    6. G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009)1, 2, 9 Rosskopf D.... Siffert W. (Hypertension 2000)
    7. [Association of alpha-adducin gene and G-protein beta3-subunit gene with essential hypertension in Chinese]. (PubMed id 17825147)1, 4, 9 Huang X.H....Hui R.T. (Zhonghua Yi Xue Za Zhi 2007)
    8. [Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity]. (PubMed id 12930636)1, 4, 9 Chen Y.Y....Hui R.T. (Zhonghua Yi Xue Za Zhi 2003)
    9. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PubMed id 19876010)1, 4, 9 Papathanasopoulos A....Zinsmeister A.R. (Obesity (Silver Spring) 2010)
    10. [Analysis of the GNB3 gene 825C/T polymorphism in non-obese and obese Chinese]. (PubMed id 19065529)1, 4, 9 Wang X....Liu B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    11. Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression. (PubMed id 17066254)1, 4, 9 Anttila S....LehtimAoki T. (J Neural Transm 2007)
    12. C825T polymorphism in the human G protein beta 3 subunit gene and preeclampsia; a case control study. (PubMed id 15369653)1, 4, 9 Jansen M.W....de Groot C.J. (Hypertens Pregnancy 2004)
    13. The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia. (PubMed id 14692527)1, 4, 9 NA1ckel H....Siffert W. (amp 2003)
    14. Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. (PubMed id 11434508)1, 4, 9 Grossmann M....Kirch W. (Pharmacogenetics 2001)
    15. Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. (PubMed id 19560507)1, 4, 9 Lin E....Lu R.B. (amp 2009)
    16. Effects of the C825T polymorphism of the GNB3 gene on body adiposity and blood pressure in fertile and menopausal women: a population-based study. (PubMed id 18192837)1, 4, 9 Casiglia E....Pessina A.C. (J. Hypertens. 2008)
    17. Association of insulin sensitivity and glucose tolerance with the c.825C&gt;T variant of the G protein beta-3 subunit gene. (PubMed id 18413224)1, 4, 9 Kopf D....Lehnert H. (J. Diabetes Complicat. 2008)
    18. Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis. (PubMed id 18793692)1, 4, 9 Souza R.P....Kennedy J.L. (amp 2008)
    19. Interaction of G-protein beta3 subunit and nitric oxide synthase gene polymorphisms on carotid artery intima-media thickness in young adults: the Bogalusa Heart Study. (PubMed id 18551105)1, 4, 9 Bhuiyan A.R....Berenson G.S. (Am. J. Hypertens. 2008)
    20. [Association of GNB3 gene C825T polymorphism with coronary heart disease]. (PubMed id 17958314)1, 4, 9 Nikitin A.G....Debabov V.G. (Genetika 2007)
    21. The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients. (PubMed id 17559964)1, 4, 9 Ahlenstiel G....Nattermann J. (J. Hepatol. 2007)
    22. Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. (PubMed id 15855877)1, 4, 9 Kiani J.G....Frossard P.M. (Neuro Endocrinol. Lett. 2005)
    23. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. (PubMed id 14647404)1, 4, 9 Lee H.J....Lee M.S. (Pharmacogenomics J. 2004)
    24. G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes. (PubMed id 12511541)1, 4, 9 FernA!ndez-Real J.M....Ricart W. (Hypertension 2003)
    25. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. (PubMed id 11230982)1, 4, 9 Hengstenberg C....Holmer S.R. (Cardiovasc. Res. 2001)
    26. [Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension]. (PubMed id 11816511)1, 4, 9 GonzA!lez-NA_A+ez D....Poch E. (Nefrologia 2001)
    27. Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene. (PubMed id 19687782)1, 4, 9 Hsiao D.J....Lin E. (Pharmacogenet. Genomics 2009)
    28. The C825T polymorphism in the G-protein beta 3 subunit gene in Chinese patients with preeclampsia. (PubMed id 19437226)1, 4, 9 He G....Bai H. (Hypertens Pregnancy 2009)
    29. Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis. (PubMed id 19811352)1, 4, 9 Panoulas V.F....Kitas G.D. (Clin. Exp. Hypertens. 2009)
    30. Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. (PubMed id 18656447)1, 4, 9 Daimon M....Kato T. (Biochem. Biophys. Res. Commun. 2008)
    31. Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities study. (PubMed id 17299380)1, 4, 9 Grove M.L....Bray M.S. (Int J Obes (Lond) 2007)
    32. Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach. (PubMed id 17521439)1, 4, 9 Anttila S....Leinonen E. (BMC Psychiatry 2007)
    33. Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese. (PubMed id 17161225)1, 4, 9 Hayakawa T....Kaneko S. (Metab. Clin. Exp. 2007)
    34. No evidence for an association between G protein beta3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia. (PubMed id 17726725)1, 4, 9 Lee H.J....Lee M.S. (Hum Psychopharmacol 2007)
    35. Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia. (PubMed id 17972053)1, 4, 9 Suwazono Y....Nogawa K. (Clin. Exp. Med. 2007)
    36. G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years. (PubMed id 16713434)1, 4, 9 Suwazono Y....Nogawa K. (Metab. Clin. Exp. 2006)
    37. Hydrochlorothiazide efficacy and polymorphisms in ACE, ADD1 and GNB3 in healthy, male volunteers. (PubMed id 16450155)1, 4, 9 Vormfelde S.V....BrockmAPller J. (Eur. J. Clin. Pharmacol. 2006)
    38. Different genotype distribution of the GNB3 C825T polymorphism of the G protein beta3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin. (PubMed id 16178055)1, 4, 9 Sheu S.Y....Schmid K.W. (J. Pathol. 2005)
    39. Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3). (PubMed id 15961981)1, 4, 9 Mitchell A....SchAofers R.F. (Clin. Pharmacol. Ther. 2005)
    40. C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population. (PubMed id 16141801)1, 4, 9 Wang Y.C....Liou Y.J. (Pharmacogenet. Genomics 2005)
    41. Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in Japanese. (PubMed id 15033462)1, 4, 9 Yamamoto M....Nakura J. (Biochem. Biophys. Res. Commun. 2004)
    42. C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. (PubMed id 15090636)1, 4, 9 Stefan N....Fritsche A. (Obes. Res. 2004)
    43. [Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2]. (PubMed id 15332573)1, 4, 9 Karpov R.S....Atroshenkov A.V. (Ter. Arkh. 2004)
    44. Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension. (PubMed id 12624609)1, 4, 9 Pamies-Andreu E....Carneado de la Fuente J. (J Hum Hypertens 2003)
    45. Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. (PubMed id 14604448)1, 4, 9 Joyce P.R....Kennedy M.A. (Int. J. Neuropsychopharmacol. 2003)
    46. Glucose and lipid metabolism in young lean normotensive males with the G protein beta3 825T-allele. (PubMed id 12730030)1, 4, 9 Saller B....Rosskopf D. (Eur. J. Med. Res. 2003)
    47. Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects. (PubMed id 12844135)1, 4, 9 NA1rnberger J....SchAofers R.F. (Clin. Pharmacol. Ther. 2003)
    48. Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. (PubMed id 12624279)1, 4, 9 Wascher T.C....Renner W. ( a journal of cerebral circulation 2003)
    49. Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disorders. (PubMed id 11586049)1, 4, 9 Lin C.N....Hong C.J. (Neuropsychobiology 2001)
    50. G-protein beta3 subunit gene splice variant in obesity and overweight. (PubMed id 11439289)1, 4, 9 Benjafield A.V....Morris B.J. (Int. J. Obes. Relat. Metab. Disord. 2001)
    51. No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation. (PubMed id 11748488)1, 4, 9 Hinney A....Hebebrand J. (amp 2001)
    52. Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction. (PubMed id 11116112)1, 4, 9 Naber C.K....Siffert W. (Hypertension 2000)
    53. Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. (PubMed id 20235788)1, 4, 9 Filigheddu F....Glorioso N. (Pharmacogenomics 2010)
    54. Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population. (PubMed id 20359253)1, 4, 9 Hsiao T.J....Lin E. (amp 2010)
    55. Genetic insight into syncopal tilted population with severe clinical presentation. (PubMed id 19243996)1, 4, 9 Lelonek M....Goch J.H. (amp 2009)
    56. Intensity of opiate withdrawal in relation to the 825C&gt;T polymorphism of the G-protein beta 3 subunit gene. (PubMed id 19303909)1, 4, 9 Lieb B....Scherbaum N. (amp 2009)
    57. Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population. (PubMed id 19772422)1, 4, 9 VAPlzke H....Rosskopf D. (Thyroid 2009)
    58. [Association of genetic factors with clinical peculiarities of hypertensive disease in patients with burdened familial anamnesis]. (PubMed id 19254215)1, 4, 9 Minushkina L.O....ZateA-shchikov D.A. (Kardiologiia 2009)
    59. Study on the interrelationship between 5-HTTLPR/G-protein beta3 subunit (C825T) polymorphisms and depressive disorder. (PubMed id 17621167)1, 4, 9 Cao M.Q....Xia D.S. (Psychiatr. Genet. 2007)
    60. Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population. (PubMed id 16493638)1, 4, 9 Mattevi V.S....Hutz M.H. (Am. J. Hum. Biol. 2006)
    61. G-protein beta3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese workers. (PubMed id 16707857)1, 4, 9 Suwazono Y....Nogawa K. (Tohoku J. Exp. Med. 2006)
    62. Better identification of patients who benefit from implantable cardioverter defibrillators by genotyping the G protein beta3 subunit (GNB3) C825T polymorphism. (PubMed id 16783490)1, 4, 9 Wieneke H....Siffert W. (Basic Res. Cardiol. 2006)
    63. Hypertension, obesity and GNB 3 gene variants. (PubMed id 16487269)1, 4, 9 Danoviz M.E....Krieger J.E. (amp 2006)
    64. GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males. (PubMed id 16314202)1, 4, 9 Kedzierska K....Chlubek D. (Arch. Med. Res. 2006)
    65. Association between the GNB3 polymorphism and blood pressure in young Korean men. (PubMed id 16015130)1, 4, 9 Lee J....Kang H.S. (Med Sci Sports Exerc 2005)
    66. GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. (PubMed id 16019105)1, 4, 9 Sarrazin C....Siffert W. (J. Hepatol. 2005)
    67. DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight. (PubMed id 16139102)1, 4, 9 Klintschar M....Kleiber M. (Forensic Sci. Int. 2005)
    68. Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals. (PubMed id 15831363)1, 4, 9 Matsunaga T....Yasuda K. (Am. J. Hypertens. 2005)
    69. [Activity of the sodium-proton exchanger and polymorphism of G-protein beta-3 subunit in patients with essential hypertension]. (PubMed id 16871746)1, 4, 9 Kedzierska K. (Ann Acad Med Stetin 2004)
    70. Lack of association of human G-protein beta 3 subunit variant with hypertension in Japanese workers. (PubMed id 15076154)1, 4, 9 Suwazono Y....Nogawa K. (J. Hypertens. 2004)
    71. Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's. (PubMed id 15212839)1, 4, 9 Bullido M.J....Valdivieso F. (Neurobiol. Aging 2004)
    72. Venous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein beta3 subunit gene (GNB3). (PubMed id 14586390)1, 4, 9 Mitchell A....SchAofers R.F. (Clin. Pharmacol. Ther. 2003)
    73. Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction. (PubMed id 12724620)1, 4, 9 Naber C.K....Erbel R. (Pharmacogenetics 2003)
    74. G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke. (PubMed id 11283377)1, 4, 9 Morrison A.C....Boerwinkle E. ( a journal of cerebral circulation 2001)
    75. Association of a human G-protein beta3 subunit variant with hypertension. (PubMed id 9425898)1, 4, 9 Siffert W....Horsthemke B. (Nat. Genet. 1998)
    76. Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine. (PubMed id 20213484)1, 4, 9 Gentile G....Martelletti P. (J Headache Pain 2010)
    77. The environmental and genetic evidence for the association of hyperlipidemia and hypertension. (PubMed id 19155782)1, 4, 9 Ruixing Y....Shangling P. (J. Hypertens. 2009)
    78. The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project. (PubMed id 19242491)1, 4, 9 Plat A.W....Kroon A.A. (J Hum Hypertens 2009)
    79. Hunger and mood during extended fasting are dependent on the GNB3 C825T polymorphism. (PubMed id 19420911)1, 4, 9 Michalsen A....Dobos G.J. (amp 2009)
    80. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4, 9 Yoshida T....Yamada Y. (Genomics 2009)
    81. Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study. (PubMed id 19148102)1, 4, 9 Sun C....Wong T.Y. (J Hum Hypertens 2009)
    82. Association of GNB3 C825T polymorphism with peak oxygen consumption. (PubMed id 19301222)1, 4, 9 Faruque M.U....Campbell A.L. (Int J Sports Med 2009)
    83. The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication. (PubMed id 19145770)1, 4, 9 Plat A.W....Kroon A.A. (J. Hypertens. 2009)
    84. The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. (PubMed id 19779330)1, 4, 9 Plat A.W....Kroon A.A. (Coron. Artery Dis. 2009)
    85. G-protein gene 825C&gt;T polymorphism is associated with response to clozapine in Brazilian schizophrenics. (PubMed id 18855531)1, 4, 9 Kohlrausch F.B....Hutz M.H. (Pharmacogenomics 2008)
    86. Genetic profile of ischemic cerebrovascular disease and carotid stenosis. (PubMed id 18325076)1, 4, 9 Kostulas K....Hillert J. (Acta Neurol. Scand. 2008)
    87. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. (PubMed id 18426866)1, 4, 9 Marvelle A.F....Mohlke K.L. (Diabetes 2008)
    88. [Study on the association of predisposing genes with essential hypertension among Kazakhs ethnic group in Xinjiang]. (PubMed id 19103106)1, 4, 9 Chen X.D....Jin L. (Zhonghua Liu Xing Bing Xue Za Zhi 2008)
    89. Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (PubMed id 19193342)1, 4, 9 Ujike H....Kuroda S. (J Clin Psychiatry 2008)
    90. Candidate genotypes associated with functional dyspepsia. (PubMed id 18331431)1, 4, 9 van Lelyveld N....Samsom M. (Neurogastroenterol. Motil. 2008)
    91. Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. (PubMed id 17066084)1, 4, 9 Bae Y....Yoon S.K. (J Hum Hypertens 2007)
    92. The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls. (PubMed id 17278960)1, 4, 9 Bagos P.G....Hamodrakas S.J. (J. Hypertens. 2007)
    93. Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine. (PubMed id 17544870)1, 4, 9 Vazquez Roque M.I....Zinsmeister A.R. (Clin. Gastroenterol. Hepatol. 2007)
    94. The C allele of the GNB3 C825T polymorphism of the G protein beta3-subunit is associated with an increased risk for the development of oncocytic thyroid tumours. (PubMed id 17136758)1, 4, 9 Sheu S.Y....Schmid K.W. (J. Pathol. 2007)
    95. Diuretic-gene interaction and the risk of myocardial infarction and stroke. (PubMed id 17189961)1, 4, 9 Schelleman H....Stricker B.H. (Pharmacogenomics J. 2007)
    96. Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. (PubMed id 16302021)1, 4, 9 Hong C.J....Tsai S.J. (Pharmacogenomics J. 2006)
    97. Serotonin 2A -1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. (PubMed id 16710319)1, 4, 9 Bishop J.R....Clayton A.H. (Neuropsychopharmacology 2006)
    98. Genetic diseases associated with heterotrimeric G proteins. (PubMed id 16600389)1, 3, 9 Weinstein L.S....Liu J. (Trends Pharmacol. Sci. 2006)
    99. Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (PubMed id 17036337)1, 4, 9 Carmichael S.L....Lammer E.J. (Am. J. Med. Genet. A 2006)
    100. Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population. (PubMed id 16276364)1, 4, 9 Pollex R.L....Hegele R.A. (Int J Obes (Lond) 2006)
    101. Polymorphisms in four candidate genes in young patients with essential hypertension. (PubMed id 16497648)1, 4, 9 Marcun Varda N....Gregoric A. (Acta Paediatr. 2006)
    102. [Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study]. (PubMed id 16615274)1, 4, 9 Suh I....Kang D.R. (J Prev Med Public Health 2006)
    103. G protein beta 3 subunit gene variants and essential hypertension in the northern Chinese Han population. (PubMed id 15996174)1, 4, 9 Li B....Chen R. (Ann. Hum. Genet. 2005)
    104. G-protein beta-3 subunit gene 825C&gt;T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. (PubMed id 15614196)1, 4, 9 Mahmood M.S....Frossard P.M. (Med. Sci. Monit. 2005)
    105. G-protein beta-3 subunit gene C825 T polymorphism: influence on plasma sodium and potassium concentrations in essential hypertensive patients. (PubMed id 16002097)1, 4, 9 MartA-n D.N....Carneado de la Fuente J. (Life Sci. 2005)
    106. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PubMed id 15978856)1, 4, 9 Meirhaeghe A....Dallongeville J. (Mol. Genet. Metab. 2005)
    107. Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study. (PubMed id 15055253)1, 4, 9 Shioji K....Iwaii N. (Hypertens. Res. 2004)
    108. C825T polymorphism of the G-protein beta3 subunit gene and atrial fibrillation: association of the TT genotype with a reduced risk for atrial fibrillation. (PubMed id 15389246)1, 4, 9 Schreieck J....Schmitt C. (Am. Heart J. 2004)
    109. G protein polymorphisms do not predict weight loss and improvement of hypertension in severely obese patients. (PubMed id 15531240)1, 4, 9 Potoczna N....Horber F.F. (J. Gastrointest. Surg. 2004)
    110. Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment. (PubMed id 15179018)1, 4, 9 Tsai S.J....Hong C.J. (Neuropsychobiology 2004)
    111. G protein beta3 subunit C825T polymorphism in primary IgA nephropathy. (PubMed id 15200440)1, 4, 9 Thibaudin L....Berthoux F. (Kidney Int. 2004)
    112. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)1, 4, 9 Matayoshi T....Kawano Y. (Hypertens. Res. 2004)
    113. SSRIs antidepressant activity is influenced by G beta 3 variants. (PubMed id 12650956)1, 4, 9 Serretti A....Smeraldi E. (Eur Neuropsychopharmacol 2003)
    114. G-protein beta3-subunit gene 825T allele and hypertension: a longitudinal study in young grade I hypertensives. (PubMed id 14557282)1, 4, 9 Sartori M....Palatini P. (Hypertension 2003)
    115. Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension. (PubMed id 12011775)1, 4, 9 Shlyakhto E.V....Konrady A.O. (Med. Sci. Monit. 2002)
    116. G-protein beta3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus. (PubMed id 12165748)1, 4, 9 Dzida G....Hanzlik J. (Med. Sci. Monit. 2002)
    117. Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants. (PubMed id 11992559)1, 4, 9 Serretti A....Smeraldi E. (Am. J. Med. Genet. 2002)
    118. Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease? (PubMed id 12476328)1, 4, 9 Bondy B....Engel R.R. (Mol. Psychiatry 2002)
    119. Effects of the G-protein beta3 subunit 825T allele on adipogenesis and lipolysis in cultured human preadipocytes and adipocytes. (PubMed id 12384823)1, 4, 9 Hauner H....Siffert W. (Horm. Metab. Res. 2002)
    120. G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function. (PubMed id 12424427)1, 4, 9 ViklickA1 O....SzabA^ A.J. (amp 2002)
    121. Association between the G protein beta3 subunit 825t allele and radial artery hypertrophy. (PubMed id 12566975)1, 4, 9 Hanon O....Girerd X. (J. Vasc. Res. 2002)
    122. Association study of eight candidate genes with renin status in mild-to-moderate hypertension in patients of African ancestry. (PubMed id 11447495)1, 4, 9 Tiago A.D....Norton G.R. (Cardiovasc J S Afr 2001)
    123. G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. (PubMed id 11244012)1, 4, 9 Zeltner R....Schmieder R.E. (Hypertension 2001)
    124. Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope. (PubMed id 20129829)1, 4 Sorrentino S....Favale S. (amp 2010)
    125. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (Biol. Psychiatry 2010)
    126. Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau. (PubMed id 20570668)1, 4 Buroker N.E....Chen S.H. ( international journal of clinical chemistry 2010)
    127. Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine. (PubMed id 20652353)1, 4 Gentile G....Martelletti P. (J Headache Pain 2010)
    128. The serotonin transporter gene polymorphism STin2 VNTR confers an increased risk of inconsistent response to triptans in migraine patients. (PubMed id 20488209)1, 4 Terrazzino S....Genazzani A.A. (Eur. J. Pharmacol. 2010)
    129. I^-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein I^-3 subunit variant. (PubMed id 20860462)1, 4 DAPrr M....Rosskopf D. (Pharmacogenomics 2010)
    130. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    131. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    132. Genetic association study of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms and the risk to develop erectile dysfunction in a German ED population. (PubMed id 20629643)1, 4 Eisenhardt A....Sperling H. (Andrologia 2010)
    133. G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial. (PubMed id 20096003)1, 4 Maree A.O....Fitzgerald D.J. (J. Thromb. Haemost. 2010)
    134. Genetic polymorphisms of the adrenergic system and implantable cardioverter-defibrillator therapies in patients with heart failure. (PubMed id 20185488)1, 4 Chemello D....Clausell N. (Europace 2010)
    135. Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer. (PubMed id 20204402)1, 4 Knechtel G....Langsenlehner U. (J. Cancer Res. Clin. Oncol. 2010)
    136. G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. (PubMed id 20337945)1, 4 Lee H.J....Jin C.J. (Neurogastroenterol. Motil. 2010)
    137. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PubMed id 20959405)1, 4 Kim D.H....Lipton J.H. (Clin. Cancer Res. 2010)
    138. The G protein I^3 subunit C825T polymorphism is associated with microalbuminuria in hypertensive women and cardiovascular disease in hypertensive men. (PubMed id 20577224)1, 4 Romundstad S....Holmen J. (Am. J. Hypertens. 2010)
    139. Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme. (PubMed id 20145952)1, 4 El Hindy N....Sandalcioglu I.E. (J. Cancer Res. Clin. Oncol. 2010)
    140. Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study. (PubMed id 20577119)1, 4 Irvin M.R....Arnett D.K. (J. Hypertens. 2010)
    141. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    142. Association of the G-protein and I+2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial. (PubMed id 20833658)1, 4 Yang Y.Y....Lee S.D. (Gut 2010)
    143. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    144. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (Diabet. Med. 2010)
    145. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    146. Beta2-adrenoceptor gene variant Arg16Gly is associated with idiopathic ventricular outflow-tract tachycardia. (PubMed id 21034538)1, 4 Ran Y.Q....Pu J.L. (Chin. Med. J. 2010)
    147. Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C&gt;T, BCL2-938C&gt;A, MCL1-386C&gt;G) in extrahepatic cholangiocarcinoma. (PubMed id 19968497)1, 4 Fingas C.D....Canbay A. (Cancer Invest. 2010)
    148. Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population. (PubMed id 20473689)1, 4 Chen S....Gu D. (Hum. Genet. 2010)
    149. The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome. (PubMed id 20170352)1, 4 DraveckA! I....HabalovA! V. (Gynecol. Endocrinol. 2010)
    150. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    151. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    152. Association between the G protein I^3 subunit C825T polymorphism and the occurrence of cardiovascular disease in hypertensives: The Nord-TrA,ndelag Health Study (HUNT). (PubMed id 20539277)1, 4 Holmen O.L....Melien O. (Am. J. Hypertens. 2010)
    153. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (Am. J. Respir. Crit. Care Med. 2010)
    154. GNB3 C825T polymorphism and elevated blood pressure. (PubMed id 19885780)1, 4 Lee J.Y....Kang H.S. (Int J Sports Med 2009)
    155. Sex-specific effect of the alpha-adducin (G460W) and AGTR1 (A1166C) polymorphism on carotid intima-media thickness. (PubMed id 19620885)1, 4 Plat A.W....Kroon A.A. (J. Hypertens. 2009)
    156. Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese. (PubMed id 19491387)1, 4 Chen H.H....Pan W.H. (Am. J. Clin. Nutr. 2009)
    157. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    158. Pharmacogenetics of low dose clonidine in irritable bowel syndrome. (PubMed id 19309415)1, 4 Camilleri M....Zinsmeister A.R. (Neurogastroenterol. Motil. 2009)
    159. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    160. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. (PubMed id 19263529)1, 4 Zee R.Y....Glynn R.J. ( international journal of clinical chemistry 2009)
    161. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    162. Genetic variation in female BMI increases with number of children born but failure to replicate association between GNbeta3 variants and increased BMI in parous females. (PubMed id 19456220)1, 4 Cornes B.K....Martin N.G. (Twin Res Hum Genet 2009)
    163. Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3). (PubMed id 19174793)1, 4 de Vries D.R....Samsom M. (Am. J. Gastroenterol. 2009)
    164. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    165. The guanine nucleotide binding protein beta polypeptide 3 gene C825T polymorphism is associated with elite endurance athletes. (PubMed id 19139061)1, 4 Eynon N....Duarte J.A. (Exp. Physiol. 2009)
    166. Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics. (PubMed id 19247266)1, 4 Bozkurt O....Klungel O.H. (Am. J. Hypertens. 2009)
    167. Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population. (PubMed id 19779464)1, 4 van Rijn-Bikker P.C....Koopmans R.P. (Am. J. Hypertens. 2009)
    168. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PubMed id 19479237)1, 4 Song X.Y....Chan J.C. (Diabetologia 2009)
    169. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C.... Davey J. (Cell. Physiol. Biochem. 2009)
    170. A splice variant of GNB3 and peripheral polyneuropathy in type 1 diabetes. (PubMed id 19597293)1, 4 Chistiakov D.A....Nosikov V.V. (Dis. Markers 2009)
    171. A candidate gene association study of 77 polymorphisms in migraine. (PubMed id 19559392)1, 4 SchA1rks M....Zee R.Y. (J Pain 2009)
    172. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. ( a journal of cerebral circulation 2009)
    173. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PubMed id 19141860)1, 4 Kim D.H....Lipton J.H. (Blood 2009)
    174. The genomic basis of cerebral palsy: a HuGE systematic literature review. (PubMed id 19238444)1, 4 O'Callaghan M.E....Dekker G. (Hum. Genet. 2009)
    175. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    176. A polymorphism in the G protein beta3-subunit gene is associated with bone metastasis risk in breast cancer patients. (PubMed id 17978878)1, 4 Clar H....Windhager R. (Breast Cancer Res. Treat. 2008)
    177. G protein beta3 subunit gene polymorphism in Turkish hypertensives. (PubMed id 18849222)1, 4 AlioA9lu E....Berdeli A. (Anadolu Kardiyol Derg 2008)
    178. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PubMed id 18513389)1, 4 Penco S....Grossi E. (BMC Bioinformatics 2008)
    179. A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults. (PubMed id 18725220)1, 4 Grudell A.B....Zinsmeister A.R. (Gastroenterology 2008)
    180. Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses. (PubMed id 18698227)1, 4 Kurnik D....Stein C.M. (Pharmacogenet. Genomics 2008)
    181. Prevalence of common disease-associated variants in Asian Indians. (PubMed id 18248681)1, 4 Pemberton T.J....Patel P.I. (BMC Genet. 2008)
    182. Candidate genes and sensory functions in health and irritable bowel syndrome. (PubMed id 18511740)1, 4 Camilleri M....Zinsmeister A.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2008)
    183. Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia. (PubMed id 18413308)1, 4 van der Net J.B....Sijbrands E.J. (Eur. Heart J. 2008)
    184. Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma. (PubMed id 18990763)1, 4 Lehnerdt G.F....Frey U.H. (amp 2008)
    185. Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant. (PubMed id 18551043)1, 4 Peters B.J....Klungel O.H. (Pharmacogenet. Genomics 2008)
    186. C825T G-protein beta3 subunit gene polymorphism, tilt test results and point score in syncopal patients. (PubMed id 18493717)1, 4 Lelonek M....Goch J.H. (Clin. Auton. Res. 2008)
    187. Genetic risk factors for renal failure among north Indian ESRD patients. (PubMed id 18242170)1, 4 Tripathi G....Agrawal S. (Clin. Biochem. 2008)
    188. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    189. G protein beta3 polymorphism and triptan response in cluster headache. (PubMed id 17361120)1, 4 SchA1rks M....Rosskopf D. (Clin. Pharmacol. Ther. 2007)
    190. The GNB3 C825T polymorphism and depression among subjects with alcohol dependence. (PubMed id 16897596)1, 4 Prestes A.P....Bau C.H. (J Neural Transm 2007)
    191. A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. (PubMed id 17564628)1, 4 Saito Y.A....Talley N.J. (Neurogastroenterol. Motil. 2007)
    192. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the QuAcbec Family Study. (PubMed id 17299381)1, 4 Bouchard L....PAcrusse L. (Int J Obes (Lond) 2007)
    193. Effects of lifestyle modification on the progression of coronary atherosclerosis, autonomic function, and angina--the role of GNB3 C825T polymorphism. (PubMed id 16569552)1, 4 Michalsen A....Dobos G.J. (Am. Heart J. 2006)
    194. G-protein beta3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level in Japanese workers. (PubMed id 16443564)1, 4 Suwazono Y....Nogawa K. (Clin. Exp. Hypertens. 2006)
    195. Studies of the association of the GNB3 825C&gt;T polymorphism with components of the metabolic syndrome in white Danes. (PubMed id 16284746)1, 4 Andersen G....Pedersen O. (Diabetologia 2006)
    196. G-protein beta3 subunit variant C825T is a risk factor for hypertension in Japanese females--a prospective cohort study over 5 years. (PubMed id 17044851)1, 4 Suwazono Y....Nogawa K. (Ann. Hum. Genet. 2006)
    197. Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders? (PubMed id 16762621)1, 4 Andresen V....Zinsmeister A.R. (Gastroenterology 2006)
    198. Role of C825T polymorphism of GNbeta3 gene in preeclampsia. (PubMed id 16867916)1, 4 Tang X....Kumar A. (Hypertens Pregnancy 2006)
    199. Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. (PubMed id 16314886)1, 4 Schelleman H....Klungel O.H. (Pharmacogenomics J. 2006)
    200. A study of candidate genotypes associated with dyspepsia in a U.S. community. (PubMed id 16464220)1, 4 Camilleri C.E....Urrutia R. (Am. J. Gastroenterol. 2006)
    201. G-protein beta-3 subunit C825T polymorphism, sodium and arterial blood pressure: a community-based study of Japanese men and women. (PubMed id 17044850)1, 4 Yamagishi K....Iso H. (Ann. Hum. Genet. 2006)
    202. The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection. (PubMed id 16938762)1, 4 Hauge Opdal S....Ole Rognum T. (Acta Paediatr. 2006)
    203. Pilot study of the G-protein beta3 subunit gene (C825T) polymorphism and clinical response to olanzapine or olanzapine-related weight gain in persons with schizophrenia. (PubMed id 16449941)1, 4 Bishop J.R....Miller D. (Med. Sci. Monit. 2006)
    204. Association between a functional polymorphism in the renin-angiotensin system and completed suicide. (PubMed id 16736244)1, 4 Hishimoto A....Maeda K. (J Neural Transm 2006)
    205. Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer. (PubMed id 16133558)1, 4 Eisenhardt A....LA1mmen G. (World J Urol 2005)
    206. GNB3 C825T polymorphism and response to anti-retroviral combination therapy in HIV-1-infected patients--a pilot study. (PubMed id 16354603)1, 4 Brockmeyer N.H....Siffert W. (Eur. J. Med. Res. 2005)
    207. The 825C/T polymorphism of G-protein beta3 subunit gene and risk of ischaemic stroke. (PubMed id 15920455)1, 4 Zhang L....Huang X. (J Hum Hypertens 2005)
    208. Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism. (PubMed id 14744475)1, 4 Johansson C....Schalling M. (Biol. Psychiatry 2004)
    209. Lack of association between human G-protein beta3 subunit variant and overweight in Japanese workers. (PubMed id 14742836)1, 4 Suwazono Y....Nogawa K. (Obes. Res. 2004)
    210. The T-allele of the C825T polymorphism is associated with higher arterial stiffness in young healthy males. (PubMed id 15037876)1, 4 NA1rnberger J....SchAofers R.F. (J Hum Hypertens 2004)
    211. Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations. (PubMed id 15138483)1, 4 Menzel H.J....Kraft H.G. (Br. J. Cancer 2004)
    212. G-protein beta3 subunit gene C825T polymorphism in patients with vesico-ureteric reflux. (PubMed id 15337465)1, 4 Zagradisnik B....Gregoric A. (Ann. Genet. 2004)
    213. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. (PubMed id 15057736)1, 4 Holtmann G....Talley N.J. (Gastroenterology 2004)
    214. The influence of G-protein beta3-subunit gene and endothelial nitric oxide synthase gene in exon 7 polymorphisms on progression of autosomal dominant polycystic kidney disease. (PubMed id 15287194)1, 4 ReiterovA! J....ViklickA1 O. (Ren Fail 2004)
    215. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    216. G protein beta3 subunit 825T allele is associated with depression in young, healthy subjects. (PubMed id 12634518)1, 4 Exton M.S....Schedlowski M. (Neuroreport 2003)
    217. G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy. (PubMed id 12668921)1, 4 Dishy V....Stein C.M. (Pharmacogenetics 2003)
    218. C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder. (PubMed id 14512207)1, 4 Willeit M....Bondy B. (Biol. Psychiatry 2003)
    219. [G protein beta 3 subunit C825T polymorphism and essential hypertension in Chinese]. (PubMed id 12947562)1, 4 Wang H....Gou S. (Beijing Da Xue Xue Bao 2003)
    220. Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety? (PubMed id 12825146)1, 4 Eisenhardt A. and Siffert W. (Herz 2003)
    221. G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease. (PubMed id 12618278)1, 4 von Beckerath N....Kastrati A. (Atherosclerosis 2003)
    222. Prediction of genetic risk for hypertension. (PubMed id 12654703)1, 4 Izawa H....Yokota M. (Hypertension 2003)
    223. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. (PubMed id 12893983)1, 4 Hauner H....Siffert W. (Pharmacogenetics 2003)
    224. An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gbeta3 C825T polymorphism. (PubMed id 12658019)1, 4 Brand E....Staessen J.A. (J. Hypertens. 2003)
    225. [Association of a polymorphic marker C825T of the beta(3) subunit of G-protein with myocardial hypertrophy in patients with hypertensive disease]. (PubMed id 12891286)1, 4 Shliakhto E.V....Konradi A.O. (Kardiologiia 2003)
    226. Lack of association between the G protein beta3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study. (PubMed id 13679998)1, 4 Huang X....Hui R. (J. Mol. Med. 2003)
    227. Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantation. (PubMed id 12460053)1, 4 Beige J....Offermann G. (Am. J. Kidney Dis. 2002)
    228. Frequencies of the G-protein beta3 subunit C825T polymorphism and the delta 32 mutation of the chemokine receptor-5 in patients with multiple sclerosis. (PubMed id 12270649)1, 4 Haase C.G....Faustmann P.M. (Neurosci. Lett. 2002)
    229. ADD1 460W allele associated with cardiovascular disease in hypertensive individuals. (PubMed id 12052841)1, 4 Morrison A.C....Boerwinkle E. (Hypertension 2002)
    230. Association of the G protein beta3 subunit T allele with insulin resistance in essential hypertension. (PubMed id 12109775)1, 4 Poch E....de la Sierra A. (Clin. Exp. Hypertens. 2002)
    231. Relation of the G protein beta3-subunit polymorphism with left ventricle structure and function. (PubMed id 12154107)1, 4 SedlA!cek K....Schunkert H. (Hypertension 2002)
    232. Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease. (PubMed id 12446192)1, 4 Ortlepp J.R....Hoffmann R. (Eur. J. Intern. Med. 2002)
    233. Positive association of maternal G protein beta3 subunit 825T allele with reduced head circumference at birth. (PubMed id 12409514)1, 4 Masuda K....Sekiya S. (Pediatr. Res. 2002)
    234. Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders. (PubMed id 12075862)1, 4 Kunugi H....Nanko S. (J Neural Transm 2002)
    235. Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent. (PubMed id 11930987)1, 4 Poston W.S....Forevt J.P. (Eat Weight Disord 2002)
    236. [Polymorphism analysis of 825C/T of the G-protein beta 3 subunit in high risk population of hypertension in the northeast China]. (PubMed id 11985260)1, 4 Dai S.P....Zhao Y.Y. (Yi Chuan Xue Bao 2002)
    237. G-protein beta3-subunit gene variant, blood pressure and erythrocyte sodium/lithium countertransport in essential hypertension. (PubMed id 12113397)1, 4 Poch E....De la Sierra A. (Br. J. Biomed. Sci. 2002)
    238. Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. (PubMed id 12082592)1, 4 Zee R.Y....Lindpainter K. (Pharmacogenomics J. 2002)
    239. G protein beta3 subunit 825T genotype is not associated with differing outcome in pediatric renal transplant recipients. (PubMed id 12000471)1, 4 Hocher B....Filler G. (Pediatr Transplant 2002)
    240. Molecular genetics of G proteins and atherosclerosis risk. (PubMed id 11770079)1, 3 Siffert W. (Basic Res. Cardiol. 2001)
    241. An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs. (PubMed id 11768721)1, 4 Obineche E.N....Bokhari A.M. (Hypertens. Res. 2001)
    242. G protein beta3 subunit variant: tendency of increasing susceptibility to hypertension in Japanese. (PubMed id 11688759)1, 4 Tozawa Y. (Blood Press. 2001)
    243. The C825T polymorphism in the G-protein beta3 subunit gene and diabetic complications in IDDM patients. (PubMed id 11322658)1, 4 Shcherbak N.S. and Schwartz E.I. (J. Hum. Genet. 2001)
    244. Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese. (PubMed id 11520049)1, 4 Ohshiro Y....Nanjo K. (Biochem. Biophys. Res. Commun. 2001)
    245. C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diuretic. (PubMed id 11230366)1, 4 Turner S.T....Boerwinkle E. (Hypertension 2001)
    246. G protein beta3 subunit gene 825T allele is associated with increased left ventricular mass in young subjects with mild hypertension. (PubMed id 11775125)1, 4 Semplicini A....Palatini P. (Am. J. Hypertens. 2001)
    247. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1997)
    248. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PubMed id 8723724)1, 2 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1996)
    249. Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide. (PubMed id 2107550)1, 2 Levine M.A.... Ahn T.G. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    250. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. (PubMed id 10701813)4, 9 Ishikawa K....Ogihara T. (Am. J. Hypertens. 2000)
    251. Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit. (PubMed id 12431187)1, 9 Rosskopf D....Siffert W. (Biochem. J. 2003)
    252. Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure. (PubMed id 19574959)1, 9 Kelly T.N....He J. (Am. J. Hypertens. 2009)
    253. [C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk]. (PubMed id 15678704)1, 9 Sartori M....Semplicini A. (Ann. Ital. Med. Int. 2004)
    254. The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. (PubMed id 20102604)1, 9 Oshima T....Miwa H. (BMC Med. Genet. 2010)
    255. Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. (PubMed id 17701674)1, 9 Lee H.J....Kim L. (Chronobiol. Int. 2007)
    256. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. (PubMed id 10526907)4, 9 Jacobi J....Schmieder R.E. (J. Hypertens. 1999)
    257. Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients. (PubMed id 18325652)1, 9 Kato M....Serretti A. (amp 2008)
    258. Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression. (PubMed id 17943025)1, 9 Kang R.H....Lee M.S. (Neuropsychobiology 2007)
    259. The angiotensin II receptor antagonist valsartan inhibits endothelin 1-induced vasoconstriction in the skin microcirculation in humans in vivo: influence of the G-protein beta3 subunit (GNB3) C825T polymorphism. (PubMed id 16513451)1, 9 Mitchell A....Wenzel R.R. (Clin. Pharmacol. Ther. 2006)
    260. Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia. (PubMed id 16139171)1, 9 MA1ller D.J....Kennedy J.L. (Eur Neuropsychopharmacol 2005)
    261. Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. (PubMed id 15226674)1, 9 Dong Y....Snieder H. (Pharmacogenetics 2004)
    262. G-Protein beta(3) subunit C825T variant, nephropathy and hypertension in patients with type 2 (Non-insulin-dependent) diabetes mellitus. (PubMed id 10970984)4, 9 Zychma M.J....Grzeszczak W. (Am. J. Nephrol. 2000)
    263. [Myocardial hypertrophy in patients with hypertensive disease: the role of genetic polymorphism of beta-adrenoreactive structures]. (PubMed id 20144152)1, 9 Minushkina L.O....ZateA-shchikov D.A. (Kardiologiia 2010)
    264. Meta-analyses of genetic studies on major depressive disorder. (PubMed id 17938638)4, 9 LA^pez-LeA^n S....van Duijn C.M. (Mol. Psychiatry 2008)
    265. Lack of association between the C825T polymorphism in G-protein beta-3 subunit and arterial blood pressure levels in cardiovascular disease free individuals: the ATTICA epidemiological study. (PubMed id 16424860)1, 9 Pitsavos C....Stefanadis C. (J Hum Hypertens 2006)
    266. Platelet hyperreactivity generalizes to multiple forms of stimulation. (PubMed id 16961612)1, 9 Yee D.L....Bray P.F. (J. Thromb. Haemost. 2006)
    267. Update on G-protein polymorphisms in hypertension. (PubMed id 16600156)1, 9 Zhu H....Dong Y. (Curr. Hypertens. Rep. 2006)
    268. G-protein beta3 subunit 825T allele and hypertension. (PubMed id 12530935)4, 9 Siffert W. (Curr. Hypertens. Rep. 2003)
    269. Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit. (PubMed id 12697327)1, 9 Rosskopf D....Siffert W. (Biochim. Biophys. Acta 2003)
    270. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. (PubMed id 11910300)1, 9 Tabara Y....Miki T. (J. Hypertens. 2002)
    271. Association analysis of G-protein beta 3 subunit gene with altered Ca(2+) homeostasis in bipolar disorder. (PubMed id 11317211)4, 9 Corson T.W....Warsh J.J. (Mol. Psychiatry 2001)
    272. G-protein beta3 subunit C825T polymorphism: no association with risk for hypertension and obesity. (PubMed id 11725157)4, 9 Snapir A....Scheinin M. (J. Hypertens. 2001)
    273. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. (PubMed id 10884039)4, 9 Zill P....Bondy B. (Neuroreport 2000)
    274. Effect of the G-protein I^3 subunit 825T allele on the change of body adiposity in obese female. (PubMed id 23061407)1 Hwang I.C....Oh S.W. (amp 2013)
    275. G protein beta3 subunit gene C825T and angiotensin converting enzyme gene insertion/deletion polymorphisms in hypertensive Tunisian population. (PubMed id 23505911)1 Kabadou I.A....Kaabachi N. (Clin. Lab. 2013)
    276. Effects of polymorphisms of NOS3 and GNB3 genes on skin microvascular reactivity in normal pregnancy. (PubMed id 23667878)1 Radkov O.V. and Volf J.V. (Bull. Exp. Biol. Med. 2013)
    277. The C825T polymorphism of the G-protein I^3 subunit gene and its association with hypertension and stroke: an updated meta-analysis. (PubMed id 23799054)1 Guo L....Li J.C. (PLoS ONE 2013)
    278. Mouse model implicates GNB3 duplication in a childhood obesity syndrome. (PubMed id 23980137)1 Goldlust I.S....Rudd M.K. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    279. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. (PubMed id 23691120)1 Kumar R....Pasha M.A. (PLoS ONE 2013)
    280. G-protein I^3 subunit gene 825C/T polymorphism and its association with the presence, severity, and duration of vasculogenic erectile dysfunction. (PubMed id 22985949)1 Safarinejad M.R....Safarinejad S. (Fertil. Steril. 2013)
    281. Genetic variants, endothelial function, and risk of preeclampsia among American Indians. (PubMed id 21174581)1 Best L.G....Anderson C.M. (Hypertens Pregnancy 2012)
    282. Association between the G-protein I^3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population. (PubMed id 22714918)1 Lu J....Wang W. (Mol. Biol. Rep. 2012)
    283. The GI^3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. (PubMed id 22940628)1 Sun Z....Chen S. (Cell. Signal. 2012)
    284. A two-stage matched case-control study on multiple hypertensive candidate genes in Han Chinese. (PubMed id 22534794)1 Kuo T.Y....Pan W.H. (Am. J. Hypertens. 2012)
    285. Influence of 825 C&gt;T polymorphism of G protein I^3 subunit gene (GNB3) on hemodynamic response during dobutamine stress echocardiography. (PubMed id 22580528)1 BanaA9 A....DroA_dzik M. (Pharmacol Rep 2012)
    286. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    287. The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level. (PubMed id 22258330)1 Casiglia E....Palatini P. (Am. J. Hypertens. 2012)
    288. Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. (PubMed id 22437554)1 Major J.M....Albanes D. (J. Nutr. 2012)
    289. The genetics of loop diuretic effects. (PubMed id 20877298)1 Vormfelde S.V. and BrockmAPller J. (Pharmacogenomics J. 2012)
    290. The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation. (PubMed id 22214232)1 Juno J....Fowke K.R. (Retrovirology 2012)
    291. GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children. (PubMed id 22882749)1 Nakao R....Tamai H. (Pediatr Int 2012)
    292. G Protein I^3 subunit gene C825T polymorphism and its association with the presence and clinicopathological characteristics of prostate cancer. (PubMed id 22608746)1 Safarinejad M.R....Safarinejad S. (J. Urol. 2012)
    293. The GNB3 C825T polymorphism influences platelet aggregation in human whole blood. (PubMed id 22082654)1 Dusse F....Peters J. (Pharmacogenet. Genomics 2012)
    294. Association between genetic variants of the ADD1 and GNB3 genes and blood pressure response to the cold pressor test in a Chinese Han population: the GenSalt Study. (PubMed id 22476228)1 Wang L....Gu D. (Hypertens. Res. 2012)
    295. [Genotype of the GNB3 C825T polymorphism, A risk factor for the development and course of prostate cancer?]. (PubMed id 21735268)1 Eisenhardt A....RA1bben H. (Urologe A 2011)
    296. Variation in GNB3 predicts response and adverse reactions to antidepressants. (PubMed id 20826553)1 Keers R....Gennarelli M. (J. Psychopharmacol. (Oxford) 2011)
    297. C825T polymorphism of the G-protein I^3 subunit and its association with essential hypertension in Uzbek males. (PubMed id 21532295)1 Khamidullaeva G.A....Abdullaeva G.J. (Turk Kardiyol Dern Ars 2011)
    298. Is there an interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms and elite athletic performance? (PubMed id 21210858)1 Eynon N....Eliakim A. (amp 2011)
    299. Can we predict top-level sports performance in power vs endurance events? A genetic approach. (PubMed id 20459474)1 Buxens A....Lucia A. (amp 2011)
    300. Association of I+-adducin and G-protein I^3 genetic polymorphisms with hypertension: a meta-analysis of Chinese populations. (PubMed id 21364877)1 Niu W. and Qi Y. (PLoS ONE 2011)
    301. [A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors]. (PubMed id 21675276)1 Polonikov A.V....Tevs D.S. (Ter. Arkh. 2011)
    302. GNB3 C825T Polymorphism and elite athletic status: A replication study with two ethnic groups. (PubMed id 21110287)1 Ruiz J.R....Lucia A. (Int J Sports Med 2011)
    303. Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome. (PubMed id 21559741)1 Markoutsaki T....Karamanolis D.G. (Dig. Dis. Sci. 2011)
    304. G-protein I^3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. (PubMed id 21902766)1 Shimpuku M....Sakamoto C. (Neurogastroenterol. Motil. 2011)
    305. Clinically silent adrenal adenomas - their relation to the metabolic syndrome and to GNB3 C825T gene polymorphism. (PubMed id 21979884)1 LazA_rovA! I....PundovA! L. (Wien. Klin. Wochenschr. 2011)
    306. The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression. (PubMed id 21709600)1 Klenke S....Siffert W. (Pharmacogenet. Genomics 2011)
    307. Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair. (PubMed id 20537417)1 Hager A....Hess J. (Int. J. Cardiol. 2011)
    308. The role of G protein I^3 subunit polymorphisms C825T, C1429T, and G5177A in Turkish subjects with essential hypertension. (PubMed id 21473734)1 Cabadak H....Kan B. (Clin. Exp. Hypertens. 2011)
    309. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. (PubMed id 20733583)1 Sarzynski M.A....Carlsson L.M. (Int J Obes (Lond) 2011)
    310. Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study. (PubMed id 21371559)1 Chen P.S....Chou Y.H. (Neuroimage 2011)
    311. Reduced prevalence of the C825T polymorphism of the G-protein beta subunit gene in women with breast cancer. (PubMed id 22034052)1 Paleari R.G....Sarian L.O. (Int. J. Biol. Markers 2011)
    312. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    313. SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study. (PubMed id 20944660)1 Sarzynski M.A....Bouchard C. (J Hum Hypertens 2011)
    314. Poor replication of candidate genes for major depressive disorder using genome-wide association data. (PubMed id 20351714)1 Bosker F.J....Nolen W.A. (Mol. Psychiatry 2011)
    315. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. (PubMed id 20660057)1 Fushan A.A....Drayna D. (Chem. Senses 2010)
    316. [Association between the polymorphism of GNB3C825T gene and vasovagal syncope in children]. (PubMed id 21215181)1 Huang Y.J....Huang M. (Zhonghua Er Ke Za Zhi 2010)
    317. The G-protein I^3 polymorphism is associated with diffuse type gastric cancer in Japanese. (PubMed id 21198262)1 Shibata T....Hirata I. (Asian Pac. J. Cancer Prev. 2010)
    318. Application of a multiplex SNP genotyping system in predicting genetic susceptibility to CAD in Chinese people of Han ethnicity. (PubMed id 21119571)4 Zhang Y....Deng X. (Med. Sci. Monit. 2010)
    319. C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients. (PubMed id 20814328)1 Chang H.H....Chen P.S. (J Clin Psychopharmacol 2010)
    320. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    321. Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study. (PubMed id 20952631)1 Sarzynski M.A....Bouchard C. (Circ Cardiovasc Genet 2010)
    322. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    323. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    324. Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C. (PubMed id 19168127)1 Poon L.S....Wong Y.H. (Cell. Signal. 2009)
    325. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    326. Estimation of single-nucleotide polymorphism allele frequency by alternately binding probe competitive polymerase chain reaction. (PubMed id 18215653)1 Noda N....Sekiguchi Y. (Anal. Chim. Acta 2008)
    327. The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. (PubMed id 18308786)1 Wang L....He L. (J. Psychopharmacol. (Oxford) 2008)
    328. The associations among GNB3 C825T polymorphism, erectile dysfunction, and related risk factors. (PubMed id 18783529)1 Lee Y.C....Chang L.L. (J Sex Med 2008)
    329. Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. (PubMed id 18071056)1 Kurnik D....Stein C.M. (Hypertension 2008)
    330. An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions. (PubMed id 17971028)1 Grudell A.B....Zinsmeister A.R. (Neurogastroenterol. Motil. 2008)
    331. Distribution of the GNB3 825C&gt;T polymorphism among Brazilians: impact of population structure. (PubMed id 18058092)1 Vargens D.D....Suarez-Kurtz G. (Eur. J. Clin. Pharmacol. 2008)
    332. G protein beta3 subunit C825T polymorphism modifies the presentation of temporal lobe epilepsy. (PubMed id 18439224)1 Osberg S....Gjerstad L. (Acta Neurol. Scand., Suppl.c 2008)
    333. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)1 Fowler C.E....Slesinger P.A. (J. Physiol. (Lond.) 2007)
    334. Influence of the G-protein beta-3 subunit gene C825 T polymorphism on the clinical phenotype of newly diagnosed essential hypertension. (PubMed id 17330058)1 Jerrard-Dunne P....Feely J. (J Hum Hypertens 2007)
    335. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. (PubMed id 17460549)1 Wilkie M.J....Smith G. (Pharmacogenet. Genomics 2007)
    336. Genetics and hypertension. (PubMed id 17341998)1 Weder A.B. (J Clin Hypertens (Greenwich) 2007)
    337. Vasovagal syncope patients and the C825T GNB3 polymorphism. (PubMed id 17584726)1 Lelonek M....Goch J.H. (Anadolu Kardiyol Derg 2007)
    338. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. (PubMed id 16884933)1 Goddard A....Davey J. (amp 2006)
    339. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    340. G-protein beta3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students. (PubMed id 16110247)1 Lee H.J....Kim L. (Neuropsychobiology 2005)
    341. Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphism. (PubMed id 15536455)1 Mitchell A....Wenzel R.R. (Clin. Pharmacol. Ther. 2004)
    342. [Prediction of genetic risk for hypertension]. (PubMed id 15046042)4 Izawa H....Yokota M. (J Cardiol 2004)
    343. Cooperative effect of GNB3 825C&gt;T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation. (PubMed id 12818251)1 Frey U.H....Siffert W. (Thromb. Res. 2003)
    344. G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. (PubMed id 12454992)1 Huang L....Euler T. (J. Comp. Neurol. 2003)
    345. Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. (PubMed id 12576843)1 Sperling H....Siffert W. (J. Urol. 2003)
    346. Glucagon and regulation of glucose metabolism. (PubMed id 12626323)1 Jiang G. and Zhang B.B. (Am. J. Physiol. 2003)
    347. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. (PubMed id 12486123)1 Cuello F....Wieland T. (J. Biol. Chem. 2003)
    348. Molecular genetics of microvascular disease in diabetic retinopathy. (PubMed id 12724690)4 Warpeha K.M. and Chakravarthy U. (Eye (Lond) 2003)
    349. Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein beta3-subunit polymorphism C825T in White Europeans. (PubMed id 12756405)1 Olszanecka A....Staessen J.A. (J Hum Hypertens 2003)
    350. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. (PubMed id 14563588)4 Hirashiki A....Yokota M. (J. Am. Coll. Cardiol. 2003)
    351. A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels. (PubMed id 12595577)1 Ruiz-Velasco V. and Ikeda S.R. (Physiol. Genomics 2003)
    352. Cardiovascular pharmacogenetics: on the way toward individually tailored drug therapy. (PubMed id 12694337)4 Siffert W. (Kidney Int. Suppl. 2003)
    353. Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors. (PubMed id 12149126)1 Lupi R....Di Girolamo M. (Biochem. J. 2002)
    354. Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. (PubMed id 12172218)1 Wenzel R.R....SchAofers R.F. (Pharmacogenetics 2002)
    355. The role of G protein beta subunits in the release of ATP from human erythrocytes. (PubMed id 12512701)1 Sprague R.S....Lonigro A.J. (J. Physiol. Pharmacol. 2002)
    356. Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells. (PubMed id 11978662)1 RydAcn M....Arner P. (Diabetes 2002)
    357. Pharmacogenetics of antidepressant and mood-stabilizing drugs: a review of candidate-gene studies and future research directions. (PubMed id 12366879)4 Lerer B. and Macciardi F. (Int. J. Neuropsychopharmacol. 2002)
    358. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    359. The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction. (PubMed id 11350093)4 Meirhaeghe A....Amouyel P. (Eur. Heart J. 2001)
    360. G-Protein beta(3)-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents. (PubMed id 10931811)4 Dobrev D....Ravens U. (Circulation 2000)
    361. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PubMed id 10339615)1 Snow B.E.... Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    362. Donor G protein beta3 subunit 825TT genotype is associated with reduced kidney allograft survival. (PubMed id 10446939)4 Beige J....Sharma A.M. (J. Am. Soc. Nephrol. 1999)
    363. The G protein subunit gene families. (PubMed id 10644457)1 Downes G.B. and Gautam N. (Genomics 1999)
    364. Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. (PubMed id 10601117)4 Dong Y....Cappuccio F.P. (Hypertension 1999)
    365. Translocation of G-protein beta3 subunit from the cytosol pool to the membrane pool by beta1-adrenergic receptor stimulation in perfused rat hearts. (PubMed id 10513993)1 Kageyama K....Kawaguchi H. (Biochem. Pharmacol. 1999)
    366. Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels. (PubMed id 9740618)4 Schunkert H....Siffert W. (Hypertension 1998)
    367. The C825T polymorphism in the human G-protein beta3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus. (PubMed id 9833937)4 Fogarty D.G....Krolewski A.S. (Diabetologia 1998)
    368. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PubMed id 9789084)1 Snow B.E.... Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    369. Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. (PubMed id 8636150)1 Yan K....Gautam N. (J. Biol. Chem. 1996)
    370. Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma. (PubMed id 8550614)1 Garcia-Higuera I....Neer E.J. (J. Biol. Chem. 1996)
    371. Lipid modifications of trimeric G proteins. (PubMed id 7822269)1 Wedegaertner P.B....Bourne H.R. (J. Biol. Chem. 1995)
    372. Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man. (PubMed id 1979057)1 Levine M.A....O'Brien S.J. (Genomics 1990)
    373. Lack of GNB3 exon 9 polymorphism in primary hypertensive and normotensive dogs. (PubMed id 17496272)9 Kuppinger O....Schulz R. (Vet. Rec. 2007)
    374. Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes. (PubMed id 17278972)9 van Rijn M.J....van Duijn C.M. (J. Hypertens. 2007)
    375. Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens. (PubMed id 17065478)9 Tummala H....Lester D.H. (amp 2006)
    376. Human G protein beta3 subunit variant does not alter hypercarbic or hypoxic ventilatory response. (PubMed id 11576163)9 Exner H.J....Peters J. (Clin Physiol 2001)
    377. G-protein beta3 subunit gene (GNB3) polymorphism 825C--&gt;T in patients with hypertensive crisis. (PubMed id 11008983)9 Buchmayer H....FAPdinger M. (Crit. Care Med. 2000)
    378. Selective absence of cone outer segment beta 3-transducin immunoreactivity in hereditary cone degeneration (cd). (PubMed id 8943701)9 Gropp K.E....Aguirre G.D. (Exp. Eye Res. 1996)
    379. Gene-gene interactions among genetic variants from obesity candidate genes for nonobese and obese populations in type 2 diabetes. (PubMed id 19594364)9 Lin E....Wu L.S. (Genet Test Mol Biomarkers 2009)
    380. Chromosomal localization of 13 candidate genes for human obesity in the pig genome. (PubMed id 19029685)9 Nowacka-Woszuk J....Switonski M. (J. Appl. Genet. 2008)
    381. [Guanine nucleotide-binding protein beta 3 subunit (GNB3) gene polymorphism]. (PubMed id 16895213)9 Ogimoto A. and Higaki J. (Nippon Rinsho 2006)
    382. [Polymorphism in guanine nucleotide-binding protein (G-protein) beta 3 subunit (GNB3) gene as a risk factor in the development of hypertensive organ damage]. (PubMed id 15171355)9 Ogimoto A. (Nippon Rinsho 2004)
    383. G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study. (PubMed id 11875193)9 Rankinen T....Bouchard C. (Physiol. Genomics 2002)
    384. [Genetic polymorphism of the G-protein beta3 subunit, obesity and essential hypertension]. (PubMed id 10713907)9 Siffert W....Erbel R. (Herz 2000)
    385. The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8. (PubMed id 10463330)9 Virchow S....Siffert W. (Naunyn Schmiedebergs Arch. Pharmacol. 1999)
    386. G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension. (PubMed id 9856980)9 Benjafield A.V....Morris B.J. (Hypertension 1998)
    387. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. (PubMed id 15917856)9 Terra S.G....Johnson J.A. (Int J Obes (Lond) 2005)
    388. Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit. (PubMed id 12890290)9 NA1rnberger J....SchAofers R.F. (Cardiovasc Diabetol 2003)
    389. Haemodynamic characterization of young normotensive men carrying the 825T-allele of the G-protein beta3 subunit. (PubMed id 11505216)9 SchAofers R.F....Michel M.C. (Pharmacogenetics 2001)
    390. G protein beta3 subunit variant and essential hypertension in Taiwan - a case-control study. (PubMed id 10817859)9 Tsai C.H....Chang J.G. (Int. J. Cardiol. 2000)
    391. G protein beta3 subunit polymorphism and risk of thrombosis and restenosis following coronary stent placement. (PubMed id 10704626)9 von Beckerath N....SchAPmig A. (Atherosclerosis 2000)
    392. G protein beta3 subunit variant and essential hypertension in Japanese. (PubMed id 9822456)9 Kato N....Yazaki Y. (Hypertension 1998)
    393. Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics. (PubMed id 19655247)9 Camilleri M. (Dig. Dis. Sci. 2009)
    394. Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. (PubMed id 18331634)9 Pacanowski M.A....Johnson J.A. (J Transl Med 2008)
    395. Genetic determination of irritable bowel syndrome. (PubMed id 19034965)9 Hotoleanu C....Dumitrascu D.L. (World J. Gastroenterol. 2008)

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