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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB3 Gene

protein-coding   GIFtS: 67
GCID: GC12P007045

guanine nucleotide binding protein (G protein), beta polypeptide...
 Explore 83 diseases affiliated with
GNB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GNB3    

Aliases
for GNB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 31 2     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 32
Transducin Beta Chain 32 3     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-32
G Protein, Beta-3 Subunit2     Hypertension Associated Protein2
GTP-Binding Regulatory Protein Beta-3 Chain2     

External Ids:    HGNC: 44001   Entrez Gene: 27842   Ensembl: ENSG000001116647   OMIM: 1391305   UniProtKB: P165203   

Export aliases for GNB3 gene to outside databases

Previous GC identifers: GC12M007019 GC12M007103 GC12P006828 GC12P006819 GC12P006977 GC12P006981 GC12P006808 GC12P006989 GC12P007001 GC12P007010 GC12P007021


Summaries
for GNB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNB3:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector
proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related
genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of
certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is
associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the
splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused
by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this
gene, but they have not been fully described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
GDP by GTP, and for G protein-effector interaction

summary for GNB3:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB3


Genomic Views
for GNB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB3 gene promoter:
         GATA-2   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   HSF2   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

GNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007045:  view genomic region     (about GC identifiers)

Start:
 6,949,118 bp from pter      End:
 6,956,557 bp from pter
Size:
 7,440 bases      Orientation:
 plus strand

Proteins
for GNB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3  
Size: 340 amino acids; 37221 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2
Secondary accessions: Q9BQC0

Explore the universe of human proteins at neXtProt for GNB3: NX_P16520

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16520

    • GNB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002066.1  
    ENSEMBL proteins: 
     ENSP00000229264   ENSP00000442002   ENSP00000439753   ENSP00000414734   ENSP00000444325  
     ENSP00000445967  
    Reactome Protein details: P16520
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GNB3
    OriGene Custom Protein Services for GNB3 
    GenScript Custom Purified and Recombinant Proteins Services for GNB3
    Novus Biologicals GNB3 Protein
    Novus Biologicals GNB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0043005neuron projection IEA--
    GO:0044297cell body IEA--


    GNB3 for ontologies           About GeneDecksing



    GNB3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNB3
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    Novus Biologicals GNB3 Antibodies
    Abcam antibodies for GNB3 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for GNB3

    Assay Products for GNB3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNB3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GNB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNB3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P16520

    ProtoNet protein and cluster: P16520

    2 Blocks protein families:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Function
    for GNB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
    GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB3:
    guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s associated
    with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant

    miRNA
    Products:            		 OriGene 3'-UTR Clone: GNB3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNB3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNB3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB3 (see all 7)
    OriGene shRNA RFP: GNB3
    OriGene siRNA: GNB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GNB3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNB3 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNB3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GNB3
    Search LifeMap BioReagents cell lines for GNB3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9425898
    GO:0004871signal transducer activity IEA--
    GO:0051020GTPase binding IPI19255495


    GNB3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GNB3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Gnb3tm1(KOMP)Vlcg for GNB3
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gnb3):
     mortality/aging  nervous system  vision/eye 

    GNB3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GNB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/72 super-pathways (see all 72) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G beta:gamma signalling through PLC beta
    8/13 pathways (see all 13)
    		G beta:gamma signalling through PLC beta1.00
    		Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.55
    		Presynaptic function of Kainate receptors0.95
    		G-protein activation0.55
    		Prostacyclin signalling through prostacyclin receptor0.77
    		Glucagon-type ligand receptors0.52
    		G-protein beta:gamma signalling0.71
    		G-Protein Signaling through Tubby Protein0.38
    2Development Angiotensin activation of ERK
    8/9 pathways (see all 9)
    		Development Angiotensin activation of ERK1.00
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development_EDNRB signaling0.54
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    3Development_A3 receptor signaling
    		Development_A3 receptor signaling1.00
    		Development A1 receptor signaling0.65
    		Development A3 receptor signaling1.00
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		Development_A1 receptor signaling0.65
    		G-protein signaling G-Protein alpha-q signaling cascades0.53
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Development_Dopamine D2 receptor transactivation of EGFR
    		Development_Dopamine D2 receptor transactivation of EGFR1.00
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		Development Dopamine D2 receptor transactivation of EGFR1.00
    		Chemotaxis_CXCR4 signaling pathway0.48
    		Development_Alpha-2 adrenergic receptor activation of ERK0.66
    		Chemotaxis CXCR4 signaling pathway0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/31 EMD Millipore Pathways for GNB3 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB3 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for GNB3
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/34 GeneGo (Thomson Reuters) Pathways for GNB3 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5 BioSystems Pathways for GNB3 
        Myometrial Relaxation and Contraction Pathways
    SIDS Susceptibility Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Visual signal transduction- Cones

    5/48        Reactome Pathways for GNB3 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    2 PharmGKB Pathways for GNB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for GNB3):
        Chemokine signaling pathway
    Glutamatergic synapse
    Cholinergic synapse
    Taste transduction


    GNB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    566/580 Interacting proteins for GNB3 (P165202, 3 ENSP000002292644) via UniProtKB, MINT, STRING, and/or I2D (see all 580) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG3P632153, ENSP000002941174I2D: score=2 STRING: ENSP00000294117
    GNG5P632183, ENSP000003596754I2D: score=2 STRING: ENSP00000359675
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GNG4P501503, ENSP000003555564I2D: score=2 STRING: ENSP00000355556
    GNG7O602623, ENSP000003715944I2D: score=2 STRING: ENSP00000371594
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    GNASP630922, ENSP000003601414MINT-7947479 STRING: ENSP00000360141
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    GSK3BP498413I2D: score=1 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ACTR2P611602MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ANAPC1Q9H1A42MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    AURKBQ96GD42MINT-7947479
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BIDP559572MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C22orf28Q9Y3I02MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNB1P146352MINT-7947479
    CCT2P783712MINT-7947479
    CCT3P493682MINT-7947479
    CCT4P509912MINT-7947479
    CCT5P486432MINT-7947479
    CCT6AP402272MINT-7947479
    CCT7Q998322MINT-7947479
    CCT8P509902MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    COPS5Q929052MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX3XO005712MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DDX6P261962MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DMAP1Q9NPF52MINT-7947479
    DNAJA1P316892MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEF1A1P681042MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S3P410912MINT-7947479
    EIF3BP558842MINT-7947479
    EIF3GO758212MINT-7947479
    EIF3IQ133472MINT-7947479
    EIF4A1P608422MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    EIF5BO608412MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000266714Q96JP22MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETF1P624952MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GAPDHP044062MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSP90AA1P079002MINT-7947479
    HSP90AB1P082382MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA5P110212MINT-7947479
    HSPA6P170662MINT-7947479
    HSPA8P111422MINT-7947479
    HSPB1P047922MINT-7947479
    HSPD1P108092MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    KPNB1Q149742MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSFP464592MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARP1P098742MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PLK1P533502MINT-7947479
    PLRG1O436602MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC3P179802MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD11O002312MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD2Q132002MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RAD50Q928782MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL22P352682MINT-7947479
    RPL24P837312MINT-7947479
    RPL31P628992MINT-7947479
    RPLP0P053882MINT-7947479
    RPS13P622772MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RUVBL2Q9Y2302MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SEH1LQ96EE32MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B14Q9Y3B42MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SMN1Q166372MINT-7947479
    SMN2Q166372MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SOGA2Q9Y4B52MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUGT1Q9Y2Z02MINT-7947479
    SUMO1P631652MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    TCP1P179872MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN1Q9Y4902MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBA4AP683662MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBA5Q9GZZ92MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    UPF1Q929002MINT-7947479
    UPF2Q9HAU52MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XRN2Q9H0D62MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YWHAEP622582MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY9ENSP000002940164STRING: ENSP00000294016
    GCGRENSP000003835584STRING: ENSP00000383558
    GNAT2ENSP000002513374STRING: ENSP00000251337
    GNAT3ENSP000003813394STRING: ENSP00000381339
    GNG11ENSP000002485644STRING: ENSP00000248564
    GNG12ENSP000003600214STRING: ENSP00000360021
    GNG2ENSP000003344484STRING: ENSP00000334448
    GNGT2ENSP000003004064STRING: ENSP00000300406
    PCSK1ENSP000003080244STRING: ENSP00000308024
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    GABBR2ENSP000002594554STRING: ENSP00000259455
    GCGENSP000003876624STRING: ENSP00000387662
    GNG8ENSP000003008734STRING: ENSP00000300873
    ADCY3ENSP000002606004STRING: ENSP00000260600
    CACNA1AENSP000003533624STRING: ENSP00000353362
    CACNA1BENSP000002775494STRING: ENSP00000277549
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    GNAI1ENSP000003430274STRING: ENSP00000343027
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNAI3ENSP000003588674STRING: ENSP00000358867
    KCNJ3ENSP000002951014STRING: ENSP00000295101
    KCNJ6ENSP000003833304STRING: ENSP00000383330
    PIK3CAENSP000002639674STRING: ENSP00000263967
    PIK3CBENSP000002891534STRING: ENSP00000289153
    PIK3CDENSP000003665634STRING: ENSP00000366563
    PIK3CGENSP000003521214STRING: ENSP00000352121
    PIK3R1ENSP000002743354STRING: ENSP00000274335
    PIK3R2ENSP000002222544STRING: ENSP00000222254
    PIK3R3ENSP000002627414STRING: ENSP00000262741
    PIK3R5ENSP000002693004STRING: ENSP00000269300
    PLCB1ENSP000003381854STRING: ENSP00000338185
    PLCB2ENSP000002604024STRING: ENSP00000260402
    PLCB3ENSP000002792304STRING: ENSP00000279230
    PLCB4ENSP000003341054STRING: ENSP00000334105
    PREX1ENSP000003610094STRING: ENSP00000361009
    GNGT1ENSP000002485724STRING: ENSP00000248572
    --C9JW422MINT-7947479
    --Q8WU302MINT-7947479
    --O957662MINT-7947479
    --Q130512MINT-7947479
    --Q7Z48 M2MINT-7947479
    --Q8TEF12MINT-7947479
    --ENSP000003230634MINT-7947479 STRING: ENSP00000323063
    --O602892MINT-7947479
    --Q9NVY62MINT-7947479
    --Q9NXK92MINT-7947479
    --Q86TR82MINT-7947479
    --Q7Z6R02MINT-7947479
    --Q133442MINT-7947479
    --ENSP000002779164MINT-7947479 STRING: ENSP00000277916
    --Q8N8M92MINT-7947479
    --Q9H6S72MINT-7947479
    --XP_2903452MINT-7947479
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS9425898
    GO:0007186G-protein coupled receptor signaling pathway TAS2107550
    GO:0007268synaptic transmission TAS--
    GO:0008217regulation of blood pressure TAS9425898


    GNB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    GRK2iGRK2 inhibitory polypeptide. Gbetagamma antagonist[148505-03-7]

    3 HMDB Compounds for GNB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    10/19 Novoseek chemical compound relationships for GNB3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nppa 62.9 2 17036337 (1), 15699455 (1)
    sibutramine 56.7 6 20359253 (2), 19687782 (2)
    thiazide 46.9 2 16450155 (1)
    sodium 31.5 4 9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
    guanine 30.4 10 17065478 (2), 15171355 (1), 19301222 (1), 18325076 (1) (see all 5)
    clozapine 20.9 6 16141801 (2), 15179018 (1), 18855531 (1)
    clonidine 20.7 1 12844135 (1)
    hydrochlorothiazide 14.1 1 16450155 (1)
    cholesterol 8.22 4 10701813 (2), 11434508 (1), 15042113 (1)
    norepinephrine 7.47 3 16513451 (1), 17544870 (1), 17642146 (1)

    10/10 PharmGKB related drug/compound annotations for GNB3 gene (see all 10)
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    lovastatinCA  
    olanzapineCA  
    pravastatinCA  
    rosuvastatinCA  
    sildenafilCA  
    simvastatinCA  
    sumatriptanCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about GNB3 / GBB3 

    Transcripts
    for GNB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNB3 gene: 
    NM_002075.2  

    Unigene Cluster for GNB3:

    Guanine nucleotide binding protein (G protein), beta polypeptide 3
    Hs.631657  [show with all ESTs]
    Unigene Representative Sequence: AB209283
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540458(uc001qrc.3) ENST00000229264(uc001qrd.3 uc009zfe.3)
    ENST00000541257 ENST00000541978 ENST00000435982 ENST00000539127 ENST00000542868
    ENST00000537035 ENST00000542751

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNB3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB3 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AB209283.1 AB593098.1 AB593099.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 
    BT009800.1 M31328.1 U47930.1 

    10 DOTS entries:

    DT.121170390  DT.112163  DT.95155927  DT.121170335  DT.40115198  DT.100779698  DT.40265129  DT.95155920 
    DT.102841594  DT.215631 

    9 AceView cDNA sequences:

    BC015920 NM_002075 BC000115 U47931 U47930 BC002454 BT009800 M31328 
    AF501884 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -     -                                               -                     
    SP2:                                            -     -                                               -     -               
    SP3:                                            -     -                                               -                     
    SP4:                                            -     -                                                                     
    SP5:                                            -                                                                           


    ECgene alternative splicing isoforms for GNB3

    Expression
    for GNB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTCTCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GNB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See GNB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB3

    SOURCE GeneReport for Unigene cluster: Hs.631657
        SABiosciences Custom PCR Arrays for GNB3
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    In Situ
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    Orthologs
    for GNB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNB3 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNB31 guanine nucleotide binding protein (G protein), beta more 81.96(n)
    93.24(a)    		   427945  XM_425517.3  XP_425517.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GNB36
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343453.1(391066-403708)
    zebrafish
    (Danio rerio)    		 Actinopterygii gnb3a1 guanine nucleotide binding protein (G protein), beta more 71.96(n)
    79.71(a)    		   436710  NM_001002437.1  NP_001002437.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta G&bgr;13F3 G-protein coupled receptor protein signaling
    pathway more    		 77(a)
    (best of 2)    		   13F16   --
    worm
    (Caenorhabditis elegans)    		 Secernentea gpb-13 guanine nucleotide-binding protein beta
    subunit    		 81(a)   II(11743881-11747549)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ELK46
    		 guanine nucleotide-binding protein subunit beta
    		 43(a)
    		 1 → many
    		 4(16477106-16479528)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 WD domain, G-beta repeat domain containing protein...
    		 42(a)
    		 1 → many
    		 3(26391617-26399638)


    ENSEMBL Gene Tree for GNB3 (if available)
    TreeFam Gene Tree for GNB3 (if available) 

    Paralogs
    for GNB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB3 gene
    GNB22  GNB12  WDR472  GNB42  GNB52  
    8 SIMAP similar genes for GNB3 using alignment to 8 protein entries:     GBB3_HUMAN (see all proteins):
    GNB1    GNB4    GNB2    GNB5    WDR61    PF20
    WDR82    GNB2L1

    GNB3 for paralogs           About GeneDecksing



    Genomic Variants
    for GNB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 NCBI SNPs in GNB3 are shown (see all 189)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774106211,2
    		--6801362(+) ATTGTA/GGGAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs38092471,2
    		C,--6802550(+) GCCTGG/CGGAGC 1 -- us2k12Minor allele frequency- C:0.17CSA WA 120
    rs38092501,2
    		C,F,H,--6802734(+) CTCTCA/CGCCAG 1 -- us2k19Minor allele frequency- C:0.10NS EA CSA WA 1292
    rs774194221,2
    		--6803138(+) GGGTCC/GCCTGT 1 -- ut510--------
    rs1118310931,2
    		--6803353(+) TCCTGG/TCCTGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs454538001,2
    		C,--6803600(+) TCTCTA/GTGGCC 1 -- int14Minor allele frequency- G:0.22WA CSA EA 242
    rs20710571,2
    		C,--6803775(+) CCGCCG/AGTCGG 1 -- ut511Minor allele frequency- A:0.00NA 2
    rs133064091,2
    		H--6804085(+) GGCACG/AAAGGG 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs732587951,2
    		C,--6804696(+) GATGCG/AAAAGA 1 -- int12Minor allele frequency- A:0.14WA 120
    rs1129631091,2
    		F,--6805036(+) AATACC/ATGATT 1 -- int12Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for GNB3 (6949118 - 6956557 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GNB3: --
    Human Gene Mutation Database (HGMD): GNB3

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    Disorders / Diseases
    for GNB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNB3 for disorders           About GeneDecksing

    OMIM gene information: 139130   
    OMIM disorders: 145500  
    20/83 diseases for GNB3 (see all 83):    About MalaCards
    essential hypertension    hypertension    obesity    seasonal affective disorder
    temporal lobe epilepsy    cluster headache    dengue hemorrhagic fever    orthostatic hypotension
    aortic coarctation    gastroesophageal reflux disease    tardive dyskinesia    type 2 diabetes mellitus
    major depressive disorder    hemorrhagic fever    coronary heart disease    myocardial infarction
    irritable bowel syndrome    amyotrophic lateral sclerosis    carotid stenosis    sleep apnea

    1 disease from the University of Copenhagen DISEASES database for GNB3:
    Hypertension

    10/31 Novoseek disease relationships for GNB3 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 79.1 39 10817859 (2), 19811352 (2), 15042113 (2), 17278960 (1) (see all 28)
    obesity 60.9 59 15090636 (3), 12730030 (3), 19065529 (2), 19594364 (2) (see all 30)
    genetic susceptibility 53.9 1 10713907 (1)
    hypertension arterial 52 8 11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see all 6)
    ventricular hypertrophy 41.1 2 12011775 (1), 15332573 (1)
    thyroid adenoma 38.5 1 17136758 (1)
    major depression 32.3 10 14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see all 7)
    insulin resistance 31.9 10 12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see all 6)
    mood disorders 28 3 11586049 (2), 11992559 (1)
    schizophrenia 26.5 4 16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)

    Genetic Association Database (GAD): GNB3
    Human Genome Epidemiology (HuGE) Navigator: GNB3 (294 documents)

    Export disorders for GNB3 gene to outside databases

    Publications
    for GNB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB3 gene, integrated from 9 sources (see all 402):
    (articles sorted by number of sources associating them with GNB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160)1, 4, 9 Krippl P....Samonigg H. (2004)
    2. G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009)1, 2, 9 Rosskopf D.... Siffert W. (2000)
    3. [Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity] (PubMed id 12930636)1, 4, 9 Chen Y.Y....Hui R.T. (2003)
    4. Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. (PubMed id 11434508)1, 4, 9 Grossmann M....Kirch W. (2001)
    5. Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. (PubMed id 15855877)1, 4, 9 Kiani J.G....Frossard P.M. (2005)
    6. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. (PubMed id 14647404)1, 4, 9 Lee H.J....Lee M.S. (2004)
    7. G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes. (PubMed id 12511541)1, 4, 9 Fernandez-Real J.M....Ricart W. (2003)
    8. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. (PubMed id 11230982)1, 4, 9 Hengstenberg C....Holmer S.R. (2001)
    9. [Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension] (PubMed id 11816511)1, 4, 9 Gonzalez-Nunez D....Poch E. (2001)
    10. Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3). (PubMed id 15961981)1, 4, 9 Mitchell A....Schafers R.F. (2005)

    External Searches for GNB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GNB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2784 HGNC: 4400 AceView: GNB3 Ensembl:ENSG00000111664 euGenes: HUgn2784
    ECgene: GNB3 Kegg: 2784 H-InvDB: GNB3

    Other Databases showing GNB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNB3 gene:
    Search GeneIP for patents involving GNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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