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GNB3 Gene

protein-coding   GIFtS: 67
GCID: GC12P007133

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...

  See GNB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 31 2     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 32
Transducin Beta Chain 32 3     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-32
G Protein, Beta-3 Subunit2     Hypertension Associated Protein2
GTP-Binding Regulatory Protein Beta-3 Chain2     

External Ids:    HGNC: 44001   Entrez Gene: 27842   Ensembl: ENSG000001116647   OMIM: 1391305   UniProtKB: P165203   

Export aliases for GNB3 gene to outside databases

Previous GC identifers: GC12M007019 GC12M007103 GC12P006828 GC12P006819 GC12P006977 GC12P006981 GC12P006808 GC12P006989 GC12P007001 GC12P007010 GC12P007021 GC12P007045 GC12P007109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNB3 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this
gene is associated with essential hypertension and obesity. This polymorphism is also associated with the
occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of
alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional
splice variants may exist for this gene, but they have not been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB3 Gene:
GNB3 (guanine nucleotide binding protein (G protein), beta polypeptide 3) is a protein-coding gene. Diseases associated with GNB3 include essential hypertension, and aortic coarctation. GO annotations related to this gene include GTPase binding and signal transducer activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNB3 gene promoter:
         GATA-2   CREB   PPAR-alpha   PPAR-gamma1   deltaCREB   HSF2   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNB3 promoter sequence
   Search Chromatin IP Primers for GNB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

GNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007133:  view genomic region     (about GC identifiers)

Start:
6,949,118 bp from pter      End:
6,956,557 bp from pter
Size:
7,440 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3  
Size: 340 amino acids; 37221 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2
Secondary accessions: Q9BQC0

Explore the universe of human proteins at neXtProt for GNB3: NX_P16520

Explore proteomics data for GNB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002066.1  
    ENSEMBL proteins: 
     ENSP00000229264   ENSP00000442002   ENSP00000439753   ENSP00000414734   ENSP00000444325  
     ENSP00000445967  
    Reactome Protein details: P16520

    GNB3 Human Recombinant Protein Products:

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    Novus Biologicals GNB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNB3 

     
    antibodies-online proteins for GNB3 (2 products) 

     
    antibodies-online peptides for GNB3

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    antibodies-online antibodies for GNB3 (40 products) 

    GNB3 Assay Products:

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    antibodies-online kits for GNB3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P16520

    ProtoNet protein and cluster: P16520

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with GNB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB3_HUMAN, P16520
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB3:
    guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant GNB3-s
    associated with essential hypertension and susceptibility factor in obesity in Inuits with the 825TT variant

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9425898
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
    GO:0051020GTPase binding IPI19255495
         
    Find genes that share ontologies with GNB3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GNB3:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnb3):
     mortality/aging  nervous system  vision/eye 

    Find genes that share phenotypes with GNB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gnb3tm1(KOMP)Vlcg for GNB3

       genOway: Develop your customized and physiologically relevant rodent model for GNB3

    miRNA
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    miRTarBase miRNAs that target GNB3:
    hsa-mir-26b-5p (MIRT029954)

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    3 qRT-PCR Assays for microRNAs that regulate GNB3:
    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNB3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNB3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for GNB3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0043005neuron projection IEA--
    GO:0044297cell body IEA--

    Find genes that share ontologies with GNB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNB3 About   (see all 72)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58


    Find genes that share SuperPaths with GNB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNB3 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for GNB3
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for GNB3 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for GNB3 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone

    Selected Reactome Pathways for GNB3 (see all 23)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    2 PharmGKB Pathways for GNB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNB3) (see all 13):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNB3
    Interactions:

        GeneGlobe Interaction Network for GNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNB3 (P165202, 3 ENSP000002292644) via UniProtKB, MINT, STRING, and/or I2D (see all 683)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG3P632153, ENSP000002941174I2D: score=2 STRING: ENSP00000294117
    GNG4P501503, ENSP000003555564I2D: score=2 STRING: ENSP00000355556
    GNG5P632183, ENSP000003596754I2D: score=2 STRING: ENSP00000359675
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GNG7O602623, ENSP000003715944I2D: score=2 STRING: ENSP00000371594
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS9425898
    GO:0007186G-protein coupled receptor signaling pathway TAS2107550
    GO:0007268synaptic transmission TAS--
    GO:0008217regulation of blood pressure TAS9425898

    Find genes that share ontologies with GNB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GNB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate
    • 5'-GDP
    • Guanosine 5'-(trihydrogen pyrophosphate)
    • Guanosine 5'-diphosphate
    • Guanosine 5'-pyrophosphate
    • GDP
    • Guanosine mono(trihydrogen diphosphate)
    • Guanosine pyrophosphate
    • guanosine-5'-diphosphate
    • guanosine-diphosphate
    • ppG
    (see top 1)
    146-91-8--
    Guanosine monophosphate
    • 5'-GMP
    • E 626
    • GMP
    • Guanidine monophosphate
    • Guanosine 5'-monophosphate
    • Guanosine 5'-phosphate
    • Guanosine 5'-phosphorate
    • Guanosine 5'-phosphoric acid
    • guanosine monophosphate
    • guanosine-5'-monophosphate
    • guanosine-5'-phosphate
    • guanosine-phosphate
    • guanylate
    • guanylic acid
    (see top 1)
    85-32-5--
    Guanosine triphosphate
    • 5'-GTP
    • GTG
    • GTP
    • Guanosine 5'-(tetrahydrogen triphosphate)
    • Guanosine 5'-triphosphate
    • Guanosine 5'-triphosphorate
    • Guanosine 5'-triphosphoric acid
    • Guanosine Triphosphate
    • Guanosine mono(tetrahydrogen triphosphate) (ester)
    • H4gtp
    (see top 1)
    86-01-1--

    Selected Novoseek inferred chemical compound relationships for GNB3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nppa 62.9 2 17036337 (1), 15699455 (1)
    sibutramine 56.7 6 20359253 (2), 19687782 (2)
    thiazide 46.9 2 16450155 (1)
    sodium 31.5 4 9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
    guanine 30.4 10 17065478 (2), 15171355 (1), 19301222 (1), 18325076 (1) (see all 5)
    clozapine 20.9 6 16141801 (2), 15179018 (1), 18855531 (1)
    clonidine 20.7 1 12844135 (1)
    hydrochlorothiazide 14.1 1 16450155 (1)
    cholesterol 8.22 4 10701813 (2), 11434508 (1), 15042113 (1)
    norepinephrine 7.47 3 16513451 (1), 17544870 (1), 17642146 (1)

    9 PharmGKB related drug/compound annotations for GNB3 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    atenololCA  
    bumetanideCA  
    furosemideCA  
    hmg coa reductase inhibitorsCA  
    olanzapineCA  
    sildenafilCA  
    sumatriptanCA  
    torasemideCA  



    Find genes that share compounds with GNB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNB3 gene: 
    NM_002075.2  

    Unigene Cluster for GNB3:

    Guanine nucleotide binding protein (G protein), beta polypeptide 3
    Hs.631657  [show with all ESTs]
    Unigene Representative Sequence: AB209283
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540458(uc001qrc.3) ENST00000229264(uc001qrd.3 uc009zfe.3)
    ENST00000541257 ENST00000541978 ENST00000435982 ENST00000539127 ENST00000542868
    ENST00000537035 ENST00000542751
    miRNA
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    hsa-miR-186* hsa-miR-3675-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNB3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: GNB3 (NM_002075)
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    Addgene plasmids for GNB3 
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      QuantiFast Probe-based Assays in human, mouse, rat GNB3

    Additional mRNA sequence: 

    AB209283.1 AB593098.1 AB593099.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 
    BT009800.1 M31328.1 U47930.1 

    9 DOTS entries:

    DT.121170390  DT.112163  DT.95155927  DT.121170335  DT.100779698  DT.40115198  DT.40265129  DT.95155920 
    DT.102841594 

    9 AceView cDNA sequences:

    NM_002075 U47931 U47930 BC002454 BC000115 BC015920 AF501884 M31328 
    BT009800 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -     -                                               -                     
    SP2:                                            -     -                                               -     -               
    SP3:                                            -     -                                               -                     
    SP4:                                            -     -                                                                     
    SP5:                                            -                                                                           


    ECgene alternative splicing isoforms for GNB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTCCTT
    GNB3 Expression
    About this image


    GNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
             Oviduct
    GNB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631657
        Custom PCR Arrays for GNB3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GNB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb31 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 89.8(n)1
    97.06(a)1
      6 (59.17 cM)5
    146951  NM_013530.11  NP_038558.11 
     1248342405 
    chicken
    (Gallus gallus)
    Aves GNB31 guanine nucleotide binding protein (G protein), beta more 81.96(n)
    93.24(a)
      427945  XM_004938118.1  XP_004938175.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNB36
    guanine nucleotide binding protein (G protein), be...
    90(a)
    1 ↔ 1
    GL343453.1(391066-403708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gnb31 guanine nucleotide binding protein (G protein), beta more 77.55(n)
    88.24(a)
      496520  NM_001011107.1  NP_001011107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gnb3a1 guanine nucleotide binding protein (G protein), beta more 71.96(n)
    79.71(a)
      436710  NM_001002437.1  NP_001002437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;13F3 G-protein coupled receptor protein
    signaling pathway more
    77(a)
    (best of 2)
      13F16   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-13 guanine nucleotide-binding protein beta
    subunit
    81(a)   II(11743881-11747549)   --


    ENSEMBL Gene Tree for GNB3 (if available)
    TreeFam Gene Tree for GNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNB3 gene
    GNB22  GNB12  WDR472  GNB52  GNB42  
    7 SIMAP similar genes for GNB3 using alignment to 8 protein entries:     GBB3_HUMAN (see all proteins):
    GNB1    GNB4    GNB2    GNB5    WDR61    PF20
    WDR82

    Find genes that share paralogs with GNB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNB3 (see all 292)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs454538001,2
    C,F--6803600(+) TCTCTA/GTGGCC 1 -- int14Minor allele frequency- G:0.22WA CSA EA 242
    rs799912961,2
    C--6803633(+) CCTCCC/AGGCTG 1 -- int12Minor allele frequency- A:0.14WA 120
    rs1931841601,2
    --6803678(+) CCCTCC/TCCCCA 1 -- int10--------
    rs1468436601,2
    --6878844(+) AGGGCC/TGCCTT 1 -- us2k10--------
    rs1397292731,2
    --6878847(+) GCCGCC/GTTGAC 1 -- us2k10--------
    rs1905958831,2
    C--6878879(+) TTCTGA/CGGTTT 1 -- us2k10--------
    rs1496863161,2
    --6878916(+) TAGTAC/TGTATT 1 -- us2k10--------
    rs774106211,2
    F--6878937(+) ATTGTA/GGGAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1833058231,2
    --6878964(+) CCTAAA/TAGAAT 1 -- us2k10--------
    rs37593471,2
    C,F,A,H--6878978(+) GCAGCG/ACCTGG 1 -- us2k117Minor allele frequency- A:0.29NS EA NA WA 2340

    HapMap Linkage Disequilibrium report for GNB3 (6949118 - 6956557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898641CNV Loss21882294
    dgv1353n71CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv898638CNV Loss21882294
    nsv832324CNV Loss17160897

    Human Gene Mutation Database (HGMD): GNB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for GNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139130   
    OMIM disorders: 145500  
    8 diseases for GNB3:    
    About MalaCards
    essential hypertension    aortic coarctation    syncope    seasonal affective disorder
    hypertension    irritable bowel syndrome    obesity    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for GNB3:
    Hypertension

    Find genes that share disorders with GNB3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GNB3 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 79.1 39 10817859 (2), 19811352 (2), 15042113 (2), 17278960 (1) (see all 28)
    obesity 60.9 59 15090636 (3), 12730030 (3), 19065529 (2), 19594364 (2) (see all 30)
    genetic susceptibility 53.9 1 10713907 (1)
    hypertension arterial 52 8 11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see all 6)
    ventricular hypertrophy 41.1 2 12011775 (1), 15332573 (1)
    thyroid adenoma 38.5 1 17136758 (1)
    major depression 32.3 10 14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see all 7)
    insulin resistance 31.9 10 12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see all 6)
    mood disorders 28 3 11586049 (2), 11992559 (1)
    schizophrenia 26.5 4 16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)

    Genetic Association Database (GAD): GNB3
    Human Genome Epidemiology (HuGE) Navigator: GNB3 (294 documents)

    Export disorders for GNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for GNB3 gene, integrated from 10 sources (see all 415):
    (articles sorted by number of sources associating them with GNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. (PubMed id 11927836)1, 4, 9 Rosskopf D....Siffert W. (Pharmacogenetics 2002)
    2. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. (PubMed id 17717746)1, 4, 9 Tahara T....Nakano H. (Dig. Dis. Sci. 2008)
    3. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. (PubMed id 16908025)1, 4, 9 Renner W....MAorz W. (Atherosclerosis 2007)
    4. The 825C&gt;T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160)1, 4, 9 Krippl P....Samonigg H. (Cancer Lett. 2004)
    5. GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. (PubMed id 15042113)1, 4, 9 Wang X....Wen H. (J Hum Hypertens 2004)
    6. G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009)1, 2, 9 Rosskopf D.... Siffert W. (Hypertension 2000)
    7. [Association of alpha-adducin gene and G-protein beta3-subunit gene with essential hypertension in Chinese]. (PubMed id 17825147)1, 4, 9 Huang X.H....Hui R.T. (Zhonghua Yi Xue Za Zhi 2007)
    8. [Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity]. (PubMed id 12930636)1, 4, 9 Chen Y.Y....Hui R.T. (Zhonghua Yi Xue Za Zhi 2003)
    9. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PubMed id 19876010)1, 4, 9 Papathanasopoulos A....Zinsmeister A.R. (Obesity (Silver Spring) 2010)
    10. [Analysis of the GNB3 gene 825C/T polymorphism in non-obese and obese Chinese]. (PubMed id 19065529)1, 4, 9 Wang X....Liu B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2784 HGNC: 4400 AceView: GNB3 Ensembl:ENSG00000111664 euGenes: HUgn2784
    ECgene: GNB3 Kegg: 2784 H-InvDB: GNB3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GNB3 gene:
    Search GeneIP for patents involving GNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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