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GNB3 Gene

protein-coding GIFtS: 69

GC12P006819

guanine nucleotide binding protein (G protein), beta polypeptide 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
G protein, beta-3 subunit ^²
GTP-binding regulatory protein beta-3 chain ^²
Transducin beta chain 3 ^², ³
guanine nucleotide binding protein (G protein), beta polypeptide 3 ^²
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 ^²
guanine nucleotide-binding protein, beta-3 subunit ^²
hypertension associated protein ^²

External Ids
HGNC: 4400¹
Entrez Gene: 2784²
UniProtKB: P16520³
Ensembl: ENSG00000111664⁷

Search outside databases for aliases for GNB3 gene

Previous GC identifers: GC12M007019 GC12M007103 GC12P006828

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GNB3:

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between

receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These

subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits

are important regulators of alpha subunits, as well as of certain signal transduction receptors

and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential

hypertension and obesity. This polymorphism is also associated with the occurrence of the splice

variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative

splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional

splice variants may exist for this gene, but they have not been fully described. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or

transducer in various transmembrane signaling systems. The beta and gamma chains are required for

the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNB3 gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

GNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006819: (about GC identifiers)

Start:	6,819,636 bp from pter
End:	6,826,818 bp from pter
Size:	7,183 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Size: 340 amino acids; 37221 Da

Subunit: G proteins are composed of 3 units, alpha, beta and gamma

Secondary accessions: Q9BQC0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002066.1

ENSEMBL proteins:

ENSP00000229264

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GNB3)
	Human Recombinant Proteins from Abnova (GNB3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348

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Antibodies for GNB3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GNB3
	Sigma-Aldrich Antibodies for GNB3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GNB3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GNB3)
	Novus Biologicals Antibodies for GNB3

Assays for GNB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P16520

ProtoNet protein and cluster: P16520

2 Blocks protein families:

IPB001632 Beta G-protein (transducin) signature

IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520

Similarity: Belongs to the WD repeat G protein beta family

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002075

Applied Biosystems Silencer® siRNAs for GNB3

Sigma-Aldrich siRNA and siRNA Panels for GNB3

Sigma-Aldrich shRNA for GNB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GNB3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_002075
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_002075
untagged cDNA clone in CMV expression vector: NM_002075

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002075

UniProtKB/Swiss-Prot: GBB3_HUMAN, P16520

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or

transducer in various transmembrane signaling systems. The beta and gamma chains are required for

the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Genatlas biochemistry entry for GNB3:

guanine nucleotide binding protein (G protein),beta,polypeptide 3,with a shortened splice variant

GNB3-s associated with essential hypertension and susceptibility factor in obesity in Inuits with

the 825TT variant

1 MGI phenotypic allele

for Gnb3 (no phenotypes)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	TAS	9425898
GO:0004871	signal transducer activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/21 Sigma-Aldrich "Your Favorite Gene" Pathways for GNB3 (Your Favorite Gene powered by Ingenuity) (see all 21 )

Riboflavin Metabolism
Role of NFAT in Regulation of the Immune Response
fMLP Signaling in Neutrophils
&alpha
Androgen Signaling

GeneDecks GNB3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GNB3

5/60 Interacting proteins for GNB3 (ENSP00000229264³) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNG13	ENSP00000248150³	STRING (score=.993)
GNGT1	ENSP00000248572³	STRING (score=.99)
GNAO1	ENSP00000262493³	STRING (score=.983)
GNGT2	ENSP00000300406³	STRING (score=.976)
GNG4	ENSP00000355556³	STRING (score=.975)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	2107550
GO:0008217	regulation of blood pressure	TAS	9425898
GO:0009755	hormone-mediated signaling	EXP	12626323

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GNB3 available from Tocris Bioscience

Compound	Action	CAS number
Gallein	Inhibitor of betagamma signaling	[2103-64-2]

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8 Novoseek chemical compound relationships for GNB3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nppa	65.20	2	17036337 (1), 15699455 (1)
sodium	31.28	4	9886871 (1), 11259340 (1), 16002097 (1), 17642146 (1)
cholesterol	10.60	4	10701813 (2), 11434508 (1), 15042113 (1)
glucose	7.64	5	12890290 (1), 12165748 (1), 15042113 (1), 12930636 (1) (see all 5)
lipid	0.98	1	12930636 (1)
potassium	0.00	4	10701813 (2), 15389246 (1), 16002097 (1)
nitric oxide	0.00	8	11434508 (2), 18551105 (2), 19145770 (1), 16497648 (1)
lithium	0.00	1	11992559 (1)

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4 PharmGKB drug compound relationships for GNB3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antidepressants	PD GN	20339098
hydrochlorothiazide	PD GN	11230366
sibutramine	PD GN	12893983
yohimbine	PD	12172218

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002075

Sigma-Aldrich siRNA and siRNA Panels for GNB3

Sigma-Aldrich shRNA for GNB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002075

REFSEQ mRNAs for GNB3 gene:

NM_002075.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002075

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_002075
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_002075
                                 untagged cDNA clone in CMV expression vector: NM_002075

Additional cDNA sequence:

AB209283.1 AF501884.1 AK313091.1 BC000115.1 BC002454.2 BC015920.1 BT009800.1 M31328.1

U47930.1

9 DOTS entries:

DT.121170390 DT.112163 DT.95155927 DT.121170335 DT.100779698 DT.40115198 DT.40265129 DT.95155920

DT.102841594

9 AceView cDNA sequences:

BC002454 NM_002075 U47930 BC000115 U47931 BC015920 M31328 AF501884

BT009800

highest scoring ESTs for GNB3:

M31328 AF501884 BC000115 BC002454 BT009800 AA136399 AA318037 AA365083 AA505020 AB209283

Unigene Cluster for GNB3:

Guanine nucleotide binding protein (G protein), beta polypeptide 3

Hs.631657 [show with all ESTs]

Unigene Representative Sequence: AB209283

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB3 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12
SP1:															-		-																-
SP2:															-		-																-		-
SP3:															-		-																-
SP4:															-		-
SP5:															-

About this scheme

ECgene alternative splicing isoforms for GNB3

1 Ensembl transcript including schematic representation:

ENST00000229264

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GNB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNB3

¹ / ² / ³

6 probe-sets matching GNB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
164_at²^{, 3}	U95-A	1	1.00	1.00	0.61	0.98	U47931	0.40	1.00	0.76	1
165_g_at²^{, 3}	U95-A	1	1.00	1.00	0.51	0.19	U47931	0.40	1.00	0.76	1
225_at²^{, 3}	U95-A	2	1.00	0.97	0.80	1.23	M31328	1.00	1.00	1.00	1
40351_at²^{, 3}	U95-A	1	0.81	1.00	0.69	0.81	M31328	1.00	1.00	1.00	1
206047_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002075	0.60	1.00	0.82	1
206047_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTCTCCTT

SOURCE GeneReport for Unigene cluster: Hs.631657
Expression variation in blood from EXPOLDB for GNB3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GNB3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNB3¹	--	guanine nucleotide binding protein (G protein), beta more	91.27(n) 96.76(a)	403511 XM_850461.1 XP_855554.1
cow (Bos taurus)	GNB3¹	--	guanine nucleotide binding protein (G protein), beta more	91.47(n) 97.35(a)	513340 XM_591008.3 XP_591008.3
rat (Rattus norvegicus)	Gnb3¹	--	guanine nucleotide binding protein (G protein), beta more	89.9(n) 96.47(a)	60449 NM_021858.2 NP_068630.1
mouse (Mus musculus)	Gnb3^{1, 5}	6 (60.19 cM)⁵	guanine nucleotide binding protein (G protein), beta more^{1, 5}	89.8(n)¹ 97.06(a)¹	14695¹ NM_013530.1¹ NP_038558.1¹ AB042402⁵ AC002397⁵ (see all 9)
chicken (Gallus gallus)	GNB3¹	--	guanine nucleotide binding protein (G protein), beta more	81.9(n) 93.18(a)	427945 XM_425517.2 XP_425517.2

About this table Species with no ortholog for GNB3

ENSEMBL Gene Tree for GNB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GNB3 gene

GNB2² GNB1² GNB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/45 NCBI SNPs in GNB3 are shown (see all 45 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs5445^1,2	A,C,F,H,O	6826441(+)	`TTTCTC/TCTTTG`	1	--	ut3¹ ese³ trp³		10		MN EU EA WA NA	754
	rs5446^1,2	A,C,F,H,O	6826723(+)	`GGCACC/TACTAG`	1	--	ut3¹ ese³		10		MN EU EA WA	1124
	rs5442^1,2	C,F,H	6825125(+)	`TCTGCG/AGCATC`	1	S/G	mis¹		15		MN EU EA WA	1620
--	rs28395775^1,2	C,F	6826271(+)	`TGACGG/AGATGG`	1	E/G	mis¹ ese³		2		--	112
	rs28395776^1,2	C,F	6825149(+)	`TCTCCC/TTCAGT`	1	L/F	mis¹ ese³ trp³		2		--	128
--	rs45569331^1,2	F	6822416(+)	`AGGTGG/ATGGGA`	1	M/V	mis¹		1		--	32
	rs5444^1,2	H	6826316(+)	`AATCTG/TGAACT`	1	W/L	mis¹		6		MN EU EA WA	674
	rs7975574^1,2	H	6826778(+)	`TTTTTT/ACTCTC`	1	--	ut3¹ ese³ trp³		4		EU EA WA	400
	rs2071057^1,2	C	6820313(+)	`CCGCCA/GGTCGG`	1	--	ut5¹		0	--	--	--	--
--	rs45616032^1,2	F	6822636(+)	`TGATCG/ATGTGG`	1	M/V	mis¹		1		--	32

About this table

HapMap Linkage Disequilibrium images for GNB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139130 disorders: 145500

10/31 Novoseek disease relationships for GNB3 gene (see all 31 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	79.05	34	10817859 (2), 15042113 (2), 17278960 (1), 10713907 (1) (see all 25)
obesity	61.41	52	15090636 (3), 12730030 (3), 19065529 (2), 10713907 (2) (see all 27)
hypertension arterial	48.88	8	11230982 (3), 11816511 (1), 12439636 (1), 15332573 (1) (see all 6)
genetic susceptibility	48.86	1	10713907 (1)
ventricular hypertrophy	42.77	2	12011775 (1), 15332573 (1)
thyroid adenoma	40.13	1	17136758 (1)
insulin resistance	34.49	10	12930636 (3), 11121369 (1), 12624279 (1), 17161225 (1) (see all 6)
major depression	31.56	10	14647404 (2), 16302021 (1), 17943025 (1), 12476328 (1) (see all 7)
mood disorders	30.22	3	11586049 (2), 11992559 (1)
schizophrenia	28.87	4	16139171 (1), 16141801 (1), 16964080 (1), 10884039 (1)

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5 PharmGKB disease relationships for GNB3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Hypertension	PD	12172218
Insulin resistance, Atherosclerosis	CO	12624279
Obesity	PD GN	12893983
affective disorders	PD GN	20339098
essential hypertension	PD GN	11230366

About this table

Human Gene Mutation Database: GNB3
Genetic Association Database: GNB3
Human Genome Epidemiology Navigator: GNB3 (219 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/306 PubMed articles for GNB3 gene (see all 306 ):

Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. (PubMed id 12624279)^{1, 3, 6, 7} Wascher T.C....Renner W. (2003)
The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. (PubMed id 15019160)^{1, 3, 6} Krippl P....Samonigg H. (2004)
G protein beta 3 gene: structure, promoter, and additional polymorphisms. (PubMed id 10904009)^{1, 3, 4} Rosskopf D.... Siffert W. (2000)
[Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity] (PubMed id 12930636)^{1, 3, 6} Chen Y.Y....Hui R.T. (2003)
Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. (PubMed id 11434508)^{1, 3, 6} Grossmann M....Kirch W. (2001)
Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. (PubMed id 15855877)^{1, 3, 6} Kiani J.G....Frossard P.M. (2005)
Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. (PubMed id 14647404)^{1, 3, 6} Lee H.J....Lee M.S. (2004)
G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes. (PubMed id 12511541)^{1, 3, 6} Fernandez-Real J.M....Ricart W. (2003)
Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. (PubMed id 11230982)^{1, 3, 6} Hengstenberg C....Holmer S.R. (2001)
[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension] (PubMed id 11816511)^{1, 3, 6} Gonzalez-Nunez D....Poch E. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2784	HGNC: 4400	AceView: GNB3	Ensembl:ENSG00000111664	euGenes: HUgn2784
ECgene: GNB3	H-InvDB: GNB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GNB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GNB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNB3		Antibodies for GNB3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GNB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GNB3)
	Antibodies (GNB3)
	Chimera RNAi (GNB3)
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	Recombinant Proteins (GNB3)
	Antibodies (GNB3)

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Antibodies for GNB3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GNB3 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GNB3

Summaries
for GNB3

Genomic Location
for GNB3

Proteins
for GNB3

Protein Domains/
Families
for GNB3

Gene Function
for GNB3

Pathways & Interactions
for GNB3

Drugs & Compounds
for GNB3

Transcripts
for GNB3

Expression
for GNB3

Orthologs
for GNB3

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for GNB3

SNPs/Variants
for GNB3

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for GNB3

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for GNB3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNB3 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GNB3

Summariesfor GNB3

Genomic Locationfor GNB3

Proteinsfor GNB3

Protein Domains/Familiesfor GNB3

Gene Functionfor GNB3

Pathways & Interactionsfor GNB3

Drugs & Compoundsfor GNB3

Transcriptsfor GNB3

Expression for GNB3

Orthologsfor GNB3

Paralogsfor GNB3

SNPs/Variantsfor GNB3

Disorders & Mutationsfor GNB3

Medical Newsfor GNB3

Publicationsfor GNB3

Search for GNB3

Genome Databases showing GNB3

Other Databases showing GNB3

Specialized Databases showing GNB3

Licensable Technologiesfor GNB3

Servicesfor GNB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNB3

Summaries
for GNB3

Genomic Location
for GNB3

Proteins
for GNB3

Protein Domains/
Families
for GNB3

Gene Function
for GNB3

Pathways & Interactions
for GNB3

Drugs & Compounds
for GNB3

Transcripts
for GNB3

Expression
for GNB3

Orthologs
for GNB3

Paralogs
for GNB3

SNPs/Variants
for GNB3

Disorders & Mutations
for GNB3

Medical News
for GNB3

Publications
for GNB3

Licensable Technologies
for GNB3

Services
for GNB3