Aliases for GNB2L1 Gene
- Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like 1 2 3
- RACK1 3 4 6
- Guanine Nucleotide-Binding Protein Subunit Beta-Like Protein 12.3 3 4
- Cell Proliferation-Inducing Gene 21 Protein 3 4
- Receptor Of Activated Protein Kinase C 1 3 4
- Human Lung Cancer Oncogene 7 Protein 3 4
- Receptor For Activated C Kinase 1 2 3
- HLC-7 3 4
- Protein Homologous To Chicken B Complex Protein, Guanine Nucleotide Binding 3
External Ids for GNB2L1 Gene
GeneCards Summary for GNB2L1 Gene
GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like 1) is a Protein Coding gene. Diseases associated with GNB2L1 include lung cancer and hay-wells syndrome. Among its related pathways are ERK Signaling and CREB Pathway. GO annotations related to this gene include receptor binding and protein phosphatase binding. An important paralog of this gene is WDR31.
UniProtKB/Swiss-Prot for GNB2L1 Gene
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.