GNB2L1 Gene
protein-coding GIFtS: 63
GCID: GC05M180663
|
|
guanine nucleotide binding protein (G protein), beta polypeptide...
| |
Aliases
for GNB2L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like11 2 | | HLC-72 3 | | RACK11 2 3 | | PIG212 | | Gnb2-Rs11 | | Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 12 | | H12.31 2 | | Lung Cancer Oncogene 72 | | Cell Proliferation-Inducing Gene 21 Protein2 3 | | Proliferation-Inducing Gene 212 | | Guanine Nucleotide-Binding Protein Subunit Beta-Like Protein 12.32 3 | | Protein Homologous To Chicken B Complex Protein, Guanine Nucleotide Binding2 | | Human Lung Cancer Oncogene 7 Protein2 3 | | Receptor For Activated C Kinase 12 | | Receptor Of Activated Protein Kinase C 12 3 | | Receptor For Activated C Kinase3 |
Export aliases for GNB2L1 gene to outside databasesPrevious GC identifers: GC05M180713 GC05P181694 GC05M180773 GC05M180596 GC05M175390 |
Summaries
for GNB2L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244Function: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with awide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involvedin translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediatedphosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activityof SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle.Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer.Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivationactivity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotescell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to thecell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A.Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and orientedcell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulatesinternalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX anddisrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulatescell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration.Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria followinginfection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cellsby binding to and activating RHOA
Gene Wiki entry for GNB2L1
|
Genomic Views
for GNB2L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNB2L1 gene promoter:
STAT5B TBP p53 Brachyury Bach2 GATA-2 HNF-1A HNF-1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNB2L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB2L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3GNB2L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M180663: view genomic region
(about GC identifiers)
Start:
|
180,663,909 bp from pter |
End:
|
180,675,096 bp from pter |
Size:
|
11,188 bases |
Orientation:
|
minus strand |
|
Proteins
for GNB2L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein subunit beta-2-like 1 Size: 317 amino acids; 35077 Da
Subunit: Component of the small (40S) ribosomal subunit (By similarity). Exists as a monomer and also forms oligomers.Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts withSRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of GNB2L1/RACK1. Recruited in acircadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1Rbut not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; theinteraction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cellmigration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinasedomain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1.Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with LARP4B. Interacts with Y.pseudotuberculosis yopK.Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nefincreases Nef phosphorylation by PKC
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm,cytoskeleton. Nucleus. Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell projection,phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-boundITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from theperinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with littleexpression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis
Sequence caution: Sequence=AAO21313.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAR24619.1; Type=Frameshift; Positions=94;
1 PDB 3D structure from  and Proteopedia  for GNB2L1:4AOW (3D)
Secondary accessions: B3KTJ0 D3DWS0 P25388 P99049 Q53HU2 Q5J8M6 Q5VLR4 Q6FH47Explore the universe of human proteins at neXtProt for GNB2L1: NX_P63244
Post-translational modifications:
Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P63244
GNB2L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006089.1
ENSEMBL proteins: ENSP00000420936 ENSP00000422198 ENSP00000426708 ENSP00000424654 ENSP00000426960 ENSP00000422316 ENSP00000426101 ENSP00000421838 ENSP00000427677 ENSP00000424760 ENSP00000366013 ENSP00000426909 ENSP00000426046 ENSP00000422768 ENSP00000425008 ENSP00000423569 ENSP00000422029 ENSP00000421416 ENSP00000426111 ENSP00000426270 ENSP00000424237 ENSP00000421356 ENSP00000394470
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
GNB2L1 for ontologies About GeneDecksing
GNB2L1 Antibody Products:
Assay Products for GNB2L1: |
Protein
Domains /
Families
for GNB2L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNB2L1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P63244ProtoNet protein and cluster: P63244 UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244Similarity: Belongs to the WD repeat G protein beta familySimilarity: Contains 7 WD repeats |
Function
for GNB2L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244Function: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with awide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involvedin translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediatedphosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activityof SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle.Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer.Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivationactivity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotescell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to thecell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A.Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and orientedcell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulatesinternalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX anddisrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulatescell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration.Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria followinginfection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cellsby binding to and activating RHOA Genatlas biochemistry entry for GNB2L1:guanine nucleotide binding protein (G protein),beta 2 like 1,involved in membrane aanchorage of protein kinaseC,homolog of a beta subunit implicated in membrane anchorage of the beta adrenergic receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GNB2L1 (NM_006098) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNB2L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB2L1 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
GNB2L1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GNB2L1:
|
Pathways & Interactions
for GNB2L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) | | | 2 | G-protein signaling_Ras family GTPases in kinase cascades (scheme) | | | 3 | Cytoskeletal Signaling | | | 4 | Ca, cAMP and Lipid Signaling | | | 5 | IL-2 Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for GNB2L1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB2L1
3 
Cell Signaling Technology (CST) Pathways for GNB2L1
3  GeneGo (Thomson Reuters) Pathways for GNB2L1
5/10  BioSystems Pathways for GNB2L1 (see all 10)
1 
Kegg Pathway (Kegg details for GNB2L1):
GNB2L1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB2L1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/450 Interacting proteins for GNB2L1 (P632441, 2, 3 ENSP000003660134) via UniProtKB, MINT, STRING, and/or I2D (see all 450)About this table
Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table
GNB2L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNB2L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GNB2L1 for compounds About GeneDecksing
 Browse Tocris compounds for GNB2L1
10/18 Novoseek chemical compound relationships for GNB2L1 gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phorbol-12-myristate |
55 |
3 |
14699138 (1), 11543740 (1), 18621736 (1) |
| geranylgeranyl pyrophosphate |
53 |
5 |
12506405 (3), 15039989 (1), 15796907 (1) |
| 17-(allylamino)-17-demethoxygeldanamycin |
50.3 |
2 |
17244529 (1), 17361105 (1) |
| pmas |
49.4 |
1 |
12963340 (1) |
| pkcs |
48.1 |
1 |
19966859 (1) |
| tyrosine |
41.9 |
38 |
12400005 (6), 17108144 (3), 11279199 (3), 15184885 (2) (see all 18) |
| threonine |
32.3 |
2 |
11279199 (1) |
| farnesyl diphosphate |
31.3 |
3 |
12506405 (2), 15039989 (1) |
| inositol 1,4,5 trisphosphate |
30.1 |
6 |
14983009 (2), 10529223 (1), 18755685 (1) |
| serine |
20.4 |
2 |
11279199 (1) |
Search CenterWatch for drugs/clinical trials and news about GNB2L1 / GBLP
|
Transcripts
for GNB2L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GNB2L1 gene: NM_006098.4 Unigene Cluster for GNB2L1: Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Hs.5662 [show with all ESTs]Unigene Representative Sequence: BF31244118/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35): ENST00000511473(uc003mni.1 uc003mnj.1) ENST00000504325 ENST00000514455
ENST00000509148 ENST00000502905 ENST00000507756 ENST00000511566 ENST00000507273
ENST00000509535 ENST00000504128 ENST00000508682 ENST00000376817 ENST00000512805
ENST00000504726 ENST00000511900 ENST00000513060 ENST00000512968 ENST00000510199
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GNB2L1 (NM_006098) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNB2L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2L1 |
Additional cDNA sequence: AK095666.1 AK222488.1 AK301029.1 AK301468.1 AK303316.1 AK310916.1 AY336089.1 BC000214.1 BC000366.2 BC010119.2 BC014256.1 BC014788.1 BC017287.2 BC019093.2 BC019362.1 BC021993.1 BC029996.1 BC032006.1 BC035460.1 CR456978.1 CR541909.1 D28398.1 GU727632.1 JN104586.1 M24194.1 24/143 DOTS entries (see all 143): DT.91782798 DT.95216507 DT.100737098 DT.100737153 DT.100060394 DT.100737172 DT.100737139 DT.100737103 DT.100842309 DT.100060381 DT.100737124 DT.97869752 DT.100737146 DT.100060385 DT.100737092 DT.120826223 DT.92324968 DT.95268530 DT.91936705 DT.100737128 DT.95268502 DT.91972228 DT.120826313 DT.95157167 24/4437 AceView cDNA sequences (see all 4437): BE782630 CN481023 BM559992 BF344618 BM480014 BU845374 BQ425519 BM993651 BU164865 BG284184 BM845549 BE781685 BM015267 CA406260 BM014482 BI761330 BE280289 BE266160 AI816438 BE298037 CN482619 BG260201 BM849107 BX402898
GeneLoc Exon Structure
|
Expression
for GNB2L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GNB2L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATGGGATC
About this image
See GNB2L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNB2L1
SOURCE GeneReport for Unigene cluster: Hs.5662
UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244Tissue specificity: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes orKupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue
SABiosciences Custom PCR Arrays for GNB2L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNB2L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNB2L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNB2L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNB2L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB2L1 |
Orthologs
for GNB2L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GNB2L1 gene from 10/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gnb2l11 , 5 |
guanine nucleotide binding protein (G protein), beta more1, 5 |
90.85(n)1
100(a)1 |
|
11 (28.77 cM)5
146941 NM_008143.31 NP_032169.11
488003325 |
chicken
(Gallus gallus) |
Aves |
GNB2L11 |
guanine nucleotide binding protein (G protein), beta more |
85.38(n)
100(a) |
|
417044 NM_001004378.2 NP_001004378.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GNB2L16 |
-- |
100(a) |
1 ↔ 1 |
2(188773052-188789474) |
African clawed frog
(Xenopus laevis) |
Amphibia |
gnb2l1-prov2 |
guanine nucleotide binding protein, beta 2, related more |
80.56(n) |
|
BC041541.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gnb2l12 |
guanine nucleotide binding protein (G protein), beta more |
83.57(n) |
|
30722 AF025330.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rack11 , 3 |
protein kinase C binding3
Receptor of activated protein kinase C 11 |
77(a)3
72.51(n)1
77.39(a)1 |
|
28D13
340701 NM_057921.31 NP_477269.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
K04D7.13
rack-11 |
guanine nucleotide-binding protein3
Protein RACK-11 |
69(a)3
68.38(n)1
74.04(a)1 |
|
IV(10176884-10178004)3
1778951 NM_069458.31 NP_501859.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ASC1(YMR116C)4
ASC11 |
G-protein beta subunit and guanine nucleotide dissociation more4
Asc1p1 |
54.83(n)1
55.05(a)1 |
|
13(500688-499456)4
8551431, 4 NP_013834.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RACK1C_AT1 |
receptor for activated C kinase 1C |
62.29(n)
67.95(a) |
|
821338 NM_112695.2 NP_188441.1 |
rice
(Oryza sativa) |
Liliopsida |
AK062179.12 |
-- |
74(n) |
|
AK062179.1 |
ENSEMBL Gene Tree for GNB2L1 (if available)
TreeFam Gene Tree for GNB2L1 (if available) |
Paralogs
for GNB2L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GNB2L1 gene
- WDR312
18/51 SIMAP similar genes for GNB2L1 using alignment to 23 protein entries: GBLP_HUMAN (see all proteins)
(see all similar genes):KIAA0101 HC6 SNRPF RHBG KIAA1651 SEC14L3
IK PARK2 MST132 pp12301 COQ5 NLN
MLL5 SEPSECS LOC100996300 SH2B3 GEMIN6 C14orf23
GNB2L1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for GNB2L1
PGOHUM00000240014 PGOHUM00000250723 PGOHUM00000235726
|
Genomic Variants
for GNB2L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GNB2L1 (180663909 - 180675096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GNB2L1
1 CNV: 51657 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNB2L1 |
|
Disorders
/ Diseases
for GNB2L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNB2L1 for disorders About GeneDecksing
OMIM gene information: 176981
OMIM disorders: --
20/37  diseases for GNB2L1 (see all 37): About MalaCardshay-wells syndrome lung cancer wells syndrome bipolar affective disorder
squamous cell carcinoma oral squamous cell carcinoma esophageal squamous cell carcinoma cystic fibrosis
bipolar disorder alzheimer's disease down syndrome epididymitis
endocarditis carcinoma leishmaniasis measles
breast cancer copd renal carcinoma fibrosis
1 disease from the University of Copenhagen DISEASES database for GNB2L1:Leishmaniasis 10 Novoseek disease relationships for GNB2L1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma squamous cell |
13.4 |
10 |
18458027 (4), 19087901 (2), 15467455 (1), 17327703 (1) |
| tumors |
1.47 |
6 |
11099474 (2), 11358958 (1), 19892429 (1), 18567578 (1) |
| necrosis |
0 |
3 |
12437589 (2), 16452584 (1) |
| breast cancer |
0 |
2 |
12385007 (1), 17936896 (1) |
| adenocarcinoma |
0 |
3 |
19892429 (3) |
| alzheimers disease |
0 |
1 |
9876970 (1) |
| carcinoma |
0 |
2 |
11099474 (1), 12645342 (1) |
| prostate cancer |
0 |
1 |
17108144 (1) |
| cancer |
0 |
3 |
11099474 (1), 18458027 (1), 20046837 (1) |
| retinoblastoma |
0 |
1 |
12734388 (1) |
Human Genome Epidemiology (HuGE) Navigator: GNB2L1 (1 document)
Export disorders for GNB2L1 gene to outside databases
|
Publications
for GNB2L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GNB2L1 gene, integrated from 9 sources (see all 282):
(articles sorted by number of sources associating them with GNB2L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. (PubMed id 2499885)1, 2, 3 Guillemot F.... Auffray C. (1989)
- RACK1: a novel substrate for the Src protein-tyrosine kinase. (PubMed id 12400005)1, 2, 9 Chang B.Y....Cartwright C.A. (2002)
- Phosphorylation of RACK1 on tyrosine 52 by c-Abl is r equired for insulin-like growth factor I-mediated regulation of focal adhesion kinase. (PubMed id 19423701)1, 2, 9 Kiely P.A....O'Connor R. (2009)
- The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1. (PubMed id 11279199)1, 2, 9 Chang B.Y....Cartwright C.A. (2001)
- RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. (PubMed id 17244529)1, 2, 9 Liu Y.V....Semenza G.L. (2007)
- RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. (PubMed id 9584165)1, 2, 9 Chang B.Y....Cartwright C.A. (1998)
- RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PubMed id 18621736)1, 2, 9 Bourd-Boittin K....Theret N. (2008)
- Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. (PubMed id 8302854)1, 3, 9 Ron D....Mochly-Rosen D. (1994)
- The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway. (PubMed id 12958311)1, 2, 9 Rigas A.C....Robson C.N. (2003)
- Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor. (PubMed id 17108144)1, 2, 9 Kraus S....Weber M.J. (2006)
|
External Searches for GNB2L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNB2L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNB2L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNB2L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GNB2L1 gene:
Search GeneIP for patents involving GNB2L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNB2L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for GNB2L1 | | OriGene shRNA RFP for GNB2L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB2L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNB2L1 | | | OriGene Protein Over-expression Lysate for GNB2L1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GNB2L1 | | OriGene 3'-UTR Clone for GNB2L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNB2L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GNB2L1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GNB2L1 | | OriGene Custom Protein Services for GNB2L1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNB2L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNB2L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB2L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB2L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNB2L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNB2L1 |
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| | Antibodies & Assays for GNB2L1 (RACK1) |
| | | | Search Tocris compounds for GNB2L1 |
| |  |  |  |  | | | | | | Recombinant Protein for GNB2L1 |
|
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|  |  |  | | | | ThermoFisher Antibodies for GNB2L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2L1 |
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