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GNB2L1 Gene

protein-coding GIFtS: 59

GC05M180596

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Gnb2-rs1 ^¹, ²
H12.3 ^¹, ²
HLC-7 ^², ³
PIG21 ^²
RACK1 ^¹, ², ³

Descriptions
Cell proliferation-inducing gene 21 protein ^³
Guanine nucleotide-binding protein subunit beta-like protein 12.3 ^³
Human lung cancer oncogene 7 protein ^³
Receptor for Activated C Kinase 1 ^²
Receptor for activated C kinase ^³
Receptor of activated protein kinase C 1 ^³
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 ^²
lung cancer oncogene 7 ^²
proliferation-inducing gene 21 ^²
protein homologous to chicken B complex protein, guanine nucleotide binding ^²

External Ids
HGNC: 4399¹
Entrez Gene: 10399²
UniProtKB: P63244³
Ensembl: ENSG00000204628⁷

Search outside databases for aliases for GNB2L1 gene

Previous GC identifers: GC05M180713 GC05P181694 GC05M180773

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244

Function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the

activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases

such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC

activation or inactivation. May play an important role in the developing brain and neuronal

differentiation

Gene Wiki entry for GNB2L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNB2L1 gene

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3

GNB2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M180596: (about GC identifiers)

Start:	180,596,534 bp from pter
End:	180,603,512 bp from pter
Size:	6,979 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein subunit beta-2-like 1

Size: 317 amino acids; 35077 Da

Subunit: Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and

KRT1

Subcellular location: Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells

Sequence caution: Sequence=AAR24619.1; Type=Frameshift; Positions=94;

Secondary accessions: B3KTJ0 P25388 P99049 Q53HU2 Q5J8M6 Q5VLR4 Q6FH47

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006089.1

ENSEMBL proteins:

ENSP00000374250 ENSP00000366013

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for GNB2L1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RACK1)
	Human Recombinant Proteins from Abnova (GNB2L1)

OriGene Purified Recombinant Human Protein: GNB2L1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0043025	cell soma	IEA	--

About this table

Antibodies for GNB2L1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GNB2L1
	R&D Systems Antibodies for GNB2L1 (RACK1)
	Antibodies from Abcam (RACK1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GNB2L1)
	Novus Biologicals Antibody for GNB2L1

Assays for GNB2L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P63244

ProtoNet protein and cluster: P63244

UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244

Domain: The WD repeats domain 5 mediates interaction with TRIM63

Similarity: Belongs to the WD repeat G protein beta family

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNB2L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006098

Applied Biosystems Silencer® siRNAs for GNB2L1

Sigma-Aldrich siRNA for GNB2L1

Sigma-Aldrich shRNA for GNB2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006098
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006098
untagged cDNA clone in CMV expression vector: NM_006098

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006098

UniProtKB/Swiss-Prot: GBLP_HUMAN, P63244

Function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the

activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases

such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC

activation or inactivation. May play an important role in the developing brain and neuronal

differentiation

Genatlas biochemistry entry for GNB2L1:

guanine nucleotide binding protein (G protein),beta 2 like 1,involved in membrane aanchorage of

protein kinase C,homolog of a beta subunit implicated in membrane anchorage of the beta adrenergic

receptor

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	NAS	12809483
GO:0019903	protein phosphatase binding	IPI	11278757

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for GNB2L1 (Your Favorite Gene powered by Ingenuity) (see all 18 )

Cardiac Hypertrophy Signaling
Cardiac &beta
CREB Signaling in Neurons
CXCR4 Signaling
Role of NFAT in Regulation of the Immune Response

GeneDecks GNB2L1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GNB2L1

5/12 Interacting proteins for GNB2L1 (P63244^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 12 )
Interactant Interaction Details
GeneCard External ID(s)
BCL2L11 O43521¹ EBI-296739, EBI-526406
DYNLL1 P63167¹ EBI-296739, EBI-349105
IFNAR2 P48551¹ EBI-296739, EBI-958408
LRP12 Q9Y561¹ EBI-296739, EBI-296693
GOLM1 Q8NBJ4² MINT-64964
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GNB2L1
10/11 Novoseek chemical compound relationships for GNB2L1 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phorbol-12-myristate	56.30	3	14699138 (1), 11543740 (1), 18621736 (1)
geranylgeranyl pyrophosphate	55.27	5	12506405 (3), 15039989 (1), 15796907 (1)
17-(allylamino)-17-demethoxygeldanamycin	52.82	2	17244529 (1), 17361105 (1)
pmas	51.49	1	12963340 (1)
tyrosine	44.09	38	12400005 (6), 17108144 (3), 11279199 (3), 15184885 (2) (see all 18)
threonine	34.47	2	11279199 (1)
farnesyl diphosphate	33.74	3	12506405 (2), 15039989 (1)
inositol 1,4,5 trisphosphate	16.20	6	14983009 (2), 10529223 (1), 18755685 (1)
oligonucleotide	11.43	2	16797713 (1), 12437589 (1)
calcium	0.00	11	14983009 (4), 16399894 (1), 17965024 (1), 18755685 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNB2L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006098

Sigma-Aldrich siRNA for GNB2L1

Sigma-Aldrich shRNA for GNB2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006098

REFSEQ mRNAs for GNB2L1 gene:

NM_006098.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006098

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006098
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006098
                                 untagged cDNA clone in CMV expression vector: NM_006098

Additional cDNA sequence:

AK095666.1 AK222488.1 AK301029.1 AK301468.1 AK303316.1 AK310916.1 AY336089.1 BC000214.1

BC000366.2 BC010119.2 BC014256.1 BC014788.1 BC017287.2 BC019093.2 BC019362.1 BC021993.1

BC029996.1 BC032006.1 BC035460.1 CR456978.1 CR541909.1 CR590014.1 CR593549.1 CR594004.1

CR594601.1 CR594655.1 CR595309.1 CR597784.1 CR597855.1 CR600581.1 CR601263.1 CR602411.1

CR603958.1 CR604041.1 CR604224.1 CR604544.1 CR605891.1 CR607176.1 CR608645.1 CR609042.1

CR609331.1 CR610245.1 CR610585.1 CR610887.1 CR613365.1 CR614554.1 CR614855.1 CR616147.1

CR616532.1 CR616617.1 CR619321.1 CR619604.1 CR621372.1 CR621495.1 CR623655.1 CR623659.1

CR624382.1 CR625098.1 CR625157.1 CR625826.1 D28398.1 M24194.1

24/140 DOTS entries (see all 140 ):

DT.91782798 DT.100737153 DT.100737098 DT.95216507 DT.100060394 DT.100737139 DT.100737172 DT.100842309

DT.100737103 DT.100060381 DT.100737124 DT.97869752 DT.100737146 DT.100060385 DT.100737092 DT.120826223

DT.92324968 DT.95268530 DT.91936705 DT.100737128 DT.95268502 DT.91972228 DT.95157167 DT.120826313

24/4437 AceView cDNA sequences (see all 4437 ):

CD109003 BM455679 BM833181 BM834700 BM910524 BU155986 BE795337 BQ899108

BF983905 BM822766 CB123806 BG913073 AA505903 BM746984 CB138988 BU175557

AW366717 CB146287 BM920752 BE301803 BM561158 BG332115 BQ962316 BI116034

highest scoring ESTs for GNB2L1:

BG437721 CB133236 D28398 AA314173 AA341655 AJ713273 AJ713395 AW248369 AW606093 BE265380

Unigene Cluster for GNB2L1:

Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Hs.5662 [show with all ESTs]

Unigene Representative Sequence: BF312441

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000389599 ENST00000376817

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GNB2L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNB2L1

¹ / ² / ³

7 probe-sets matching GNB2L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34609_g_at²^{, 3}	U95-A	2	1.00	0.94	0.97	0.94	M24194	0.80	0.67	0.74	1
34608_at²^{, 3}	U95-A	2	1.00	0.91	0.84	1.07	M24194	0.80	0.67	0.74	1
73163_f_at²^{, 3}	U95-E	2	0.62	0.90	0.89	0.99	AI890065	0.40	1.00	0.76	1
200651_at²^{, 3}	U133-A	2	1.00	0.86	--	--	NM_006098	0.60	1.00	0.82	1
222034_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AA443762	0.20	1.00	0.72	1
200651_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
222034_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTATGGGATC

SOURCE GeneReport for Unigene cluster: Hs.5662
Expression variation in blood from EXPOLDB for GNB2L1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GNB2L1 gene from 5/27 species (see all 27 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNB2L1¹	--	guanine nucleotide binding protein (G protein), beta more	89.98(n) 99.68(a)	480818 XM_537934.2 XP_537934.2
chimpanzee (Pan troglodytes)	GNB2L1¹	--	guanine nucleotide binding protein (G protein), beta more	99.47(n) 100(a)	462344 XM_518165.2 XP_518165.2
cow (Bos taurus)	GNB2L1¹	--	guanine nucleotide binding protein (G protein), beta more	92.22(n) 100(a)	327682 XM_001254598.1 XP_001254599.1
rat (Rattus norvegicus)	Gnb2l1¹	--	guanine nucleotide binding protein (G protein), beta more	90.96(n) 99.68(a)	83427 NM_130734.1 NP_570090.1
mouse (Mus musculus)	Gnb2l1^{1, 5}	11⁵	guanine nucleotide binding protein (G protein), beta more^{1, 5}	90.85(n)¹ 100(a)¹	14694¹ NM_008143.3¹ NP_032169.1¹ AF295529⁵ AK012242⁵ (see all 35)

About this table Species with no ortholog for GNB2L1

ENSEMBL Gene Tree for GNB2L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GNB2L1 gene

WDR51B² WDR51A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/130 NCBI SNPs in GNB2L1 are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 71)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2770994^1,2	A,C,F,H,O	180596306(+)	`CACGTG/AGTATG`	1	--	ng5¹		16		NS NA EU EA WA	1082
	rs3806919^1,2	A,C,F,H	180603607(+)	`GCCATG/ATAATG`	1	--	ng3¹		10		EA NA MN EU WA	2184
	rs1279736^1,2	A,C,F,H	180603795(-)	`CAGCCC/AGGCGG`	1	--	ng3¹		4		EU EA WA	404
	rs3756585^1,2	A,C,F,H	180603635(-)	`ATGCCT/GTGCAA`	1	--	ng3¹		7		EA MN EU WA	2226
	rs2241369^1,2	C,F,H	180603464(+)	`TTAGAG/CAAACT`	1	--	ut5¹		8		EA NA EU WA	2054
	rs10078827^1,2	F,H	180605459(+)	`AAACAG/TCTTGC`	1	--	ng3¹		4		EU EA WA	370
	rs2545097^1,2	A,C	180596417(-)	`TTTGAA/GGGGGA`	1	--	ng5¹		0	--	--	--	--
	rs10078822^1,2	F,H	180605441(+)	`GGCCAG/AGATCC`	1	--	ng3¹		4		EU EA WA	410
--	rs1279735^1,2	A,C	180604164(-)	`gacctC/Taagtg`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs11540200^1,2	C	180597729(-)	`GCTGCC/TACAGG`	1	A/A	syn¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for GNB2L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176981

9 Novoseek disease relationships for GNB2L1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	4.66	10	18458027 (4), 19087901 (2), 15467455 (1), 17327703 (1)
retinoblastoma	1.00	1	12734388 (1)
necrosis	0.00	3	12437589 (2), 16452584 (1)
cancer	0.00	2	11099474 (1), 18458027 (1)
carcinoma	0.00	2	11099474 (1), 12645342 (1)
breast cancer	0.00	2	12385007 (1), 17936896 (1)
tumors	0.00	4	11099474 (2), 11358958 (1), 18567578 (1)
alzheimers disease	0.00	1	9876970 (1)
prostate cancer	0.00	1	17108144 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/186 PubMed articles for GNB2L1 gene (see all 186 ):

Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. (PubMed id 2499885)^{2, 3, 4} Guillemot F....Auffray C. (1989)
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. (PubMed id 8302854)^{1, 2, 3} Ron D....Mochly-Rosen D. (1994)
Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PubMed id 14699138)^{1, 3, 4} Nery F.C.... Kobarg J. (2004)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Muscle ring finger protein-1 inhibits PKC-epsilon activation and prevents cardiomyocyte hypertrophy. (PubMed id 15596539)^{3, 4} Arya R....Patterson C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. (PubMed id 11956211)^{3, 4} Liedtke C.M.... Wang D. (2002)
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. (PubMed id 16705158)^{1, 3} Kiely P.A....O'Connor R. (2006)
RACK1: a novel substrate for the Src protein-tyrosine kinase. (PubMed id 12400005)^{1, 3} Chang B.Y....Cartwright C.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10399	HGNC: 4399	AceView: GNB2L1	Ensembl:ENSG00000204628	euGenes: HUgn10399
ECgene: GNB2L1	H-InvDB: GNB2L1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GNB2L1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GNB2L1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GNB2L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNB2L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNB2L1		Antibodies for GNB2L1
	Explore super-pooled esiRNAs		Proteins for GNB2L1
	Lentivirus-delivered shRNAs for GNB2L1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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GNB2L1 Gene

protein-coding GIFtS: 59

Aliases &
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for GNB2L1

Summaries
for GNB2L1

Genomic Location
for GNB2L1

Proteins
for GNB2L1

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Orthologs
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNB2L1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor GNB2L1

Summariesfor GNB2L1

Genomic Locationfor GNB2L1

Proteinsfor GNB2L1

Protein Domains/Familiesfor GNB2L1

Gene Functionfor GNB2L1

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Expression for GNB2L1

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Search for GNB2L1

Genome Databases showing GNB2L1

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Specialized Databases showing GNB2L1

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Servicesfor GNB2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNB2L1

Summaries
for GNB2L1

Genomic Location
for GNB2L1

Proteins
for GNB2L1

Protein Domains/
Families
for GNB2L1

Gene Function
for GNB2L1

Pathways & Interactions
for GNB2L1

Drugs & Compounds
for GNB2L1

Transcripts
for GNB2L1

Expression
for GNB2L1

Orthologs
for GNB2L1

Paralogs
for GNB2L1

SNPs/Variants
for GNB2L1

Disorders & Mutations
for GNB2L1

Medical News
for GNB2L1

Publications
for GNB2L1

Licensable Technologies
for GNB2L1

Services
for GNB2L1