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Aliases for GNB2 Gene

Aliases for GNB2 Gene

  • G Protein Subunit Beta 2 2 3 5
  • Transducin Beta Chain 2 2 4
  • Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit 2
  • Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2 2
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 2 2
  • G Protein, Beta-2 Subunit 2
  • G Protein Subunit Beta-2 4

External Ids for GNB2 Gene

Previous GeneCards Identifiers for GNB2 Gene

  • GC07P098805
  • GC07P099868
  • GC07P099882
  • GC07P099918
  • GC07P100110
  • GC07P100271
  • GC07P094902

Summaries for GNB2 Gene

Entrez Gene Summary for GNB2 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNB2 Gene

GNB2 (G Protein Subunit Beta 2) is a Protein Coding gene. Among its related pathways are CCR5 Pathway in Macrophages and Aquaporin-mediated transport. GO annotations related to this gene include GTPase activity and protein complex binding. An important paralog of this gene is GNB1.

UniProtKB/Swiss-Prot for GNB2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNB2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNB2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNB2 Gene

Genomics for GNB2 Gene

Regulatory Elements for GNB2 Gene

Enhancers for GNB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100427 1.5 ENCODE dbSUPER 11 -240.3 -240332 10.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 PILRA ZSCAN25 LOC100131859 ZNF655 STAG3L5P GIGYF1 COPS6 MBLAC1 AP4M1 ZNF789
GH07G100672 1.4 ENCODE dbSUPER 11.7 +3.5 3462 8.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 GIGYF1 PCOLCE ZAN MBLAC1 PPP1R35 COPS6 STAG3L5P CNPY4 MOSPD3 NYAP1
GH07G100886 1.4 ENCODE dbSUPER 11 +215.8 215798 5.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ACHE SLC12A9 MOSPD3 MUC3A AGFG2 GNB2 PPP1R35 FIS1 GC07M100887 UFSP1
GH07G100014 1.3 ENCODE dbSUPER 10.9 -657.0 -656959 3.4 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZSCAN25 AP4M1 SMURF1 ZSCAN21 GNB2 PPP1R35 PVRIG ZNF655 TRIM4 ZKSCAN1
GH07G100873 1.2 ENCODE 11 +201.8 201776 2.9 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 PPP1R35 ACHE SLC12A9 TRIP6 MUC3A GIGYF1 AP4M1 GNB2 STAG3L5P EPHB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNB2 on UCSC Golden Path with GeneCards custom track

Promoters for GNB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215840 1269 3201 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263

Genomic Location for GNB2 Gene

Chromosome:
7
Start:
100,673,531 bp from pter
End:
100,679,174 bp from pter
Size:
5,644 bases
Orientation:
Plus strand

Genomic View for GNB2 Gene

Genes around GNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNB2 Gene

Proteins for GNB2 Gene

  • Protein details for GNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62879-GBB2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
    Protein Accession:
    P62879
    Secondary Accessions:
    • B3KPU1
    • P11016
    • P54312

    Protein attributes for GNB2 Gene

    Size:
    340 amino acids
    Molecular mass:
    37331 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A (PubMed:26900580).

    Alternative splice isoforms for GNB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNB2 Gene

Post-translational modifications for GNB2 Gene

  • Ubiquitination at Lys23, Lys209, and Lys301
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GNB2 Gene

Domains & Families for GNB2 Gene

Graphical View of Domain Structure for InterPro Entry

P62879

UniProtKB/Swiss-Prot:

GBB2_HUMAN :
  • Belongs to the WD repeat G protein beta family.
Family:
  • Belongs to the WD repeat G protein beta family.
genes like me logo Genes that share domains with GNB2: view

Function for GNB2 Gene

Molecular function for GNB2 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),beta,polypeptide 2,containing a CCG repeat in 5utr
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 2902634
GO:0004871 signal transducer activity IEA --
GO:0005246 calcium channel regulator activity IEA --
GO:0005515 protein binding IPI 16498633
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with GNB2: view
genes like me logo Genes that share phenotypes with GNB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNB2
  • Applied Biological Materials Clones for GNB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNB2 Gene

Localization for GNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNB2 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNB2 gene
Compartment Confidence
extracellular 5
cytosol 5
lysosome 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNB2: view

Pathways & Interactions for GNB2 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
2 ADP signalling through P2Y purinoceptor 12
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 Development Dopamine D2 receptor transactivation of EGFR
genes like me logo Genes that share pathways with GNB2: view

SIGNOR curated interactions for GNB2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7649993
GO:0065009 regulation of molecular function IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNB2: view

Drugs & Compounds for GNB2 Gene

(3) Drugs for GNB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNB2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNB2 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNB2: view

Transcripts for GNB2 Gene

Unigene Clusters for GNB2 Gene

Guanine nucleotide binding protein (G protein), beta polypeptide 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNB2
  • Applied Biological Materials Clones for GNB2

Alternative Splicing Database (ASD) splice patterns (SP) for GNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for GNB2 Gene

GeneLoc Exon Structure for
GNB2
ECgene alternative splicing isoforms for
GNB2

Expression for GNB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNB2 Gene

This gene is overexpressed in Whole Blood (x6.6).

Protein differential expression in normal tissues from HIPED for GNB2 Gene

This gene is overexpressed in Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNB2 Gene



Protein tissue co-expression partners for GNB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNB2 Gene:

GNB2

SOURCE GeneReport for Unigene cluster for GNB2 Gene:

Hs.185172

Evidence on tissue expression from TISSUES for GNB2 Gene

  • Pancreas(4.7)
  • Skin(4.5)
  • Nervous system(4.4)
  • Lung(4.1)
  • Intestine(3.1)
  • Blood(2.9)
  • Eye(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GNB2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNB2 Gene

Orthologs for GNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNB2 34 35
  • 99.61 (n)
oppossum
(Monodelphis domestica)
Mammalia GNB2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNB2 34 35
  • 94.71 (n)
cow
(Bos Taurus)
Mammalia GNB2 35 34
  • 94.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gnb2 16 35 34
  • 92.65 (n)
rat
(Rattus norvegicus)
Mammalia Gnb2 34
  • 92.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GNB2 35
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gnb2 34 35
  • 79.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gbgr13F 36
  • 81 (a)
Gbeta13F 35
  • 81 (a)
OneToMany
Gbgr76C 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005913 34
  • 72.35 (n)
worm
(Caenorhabditis elegans)
Secernentea gpb-1 36 35
  • 85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10536 35
  • 78 (a)
OneToMany
Species where no ortholog for GNB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GNB2 Gene

ENSEMBL:
Gene Tree for GNB2 (if available)
TreeFam:
Gene Tree for GNB2 (if available)

Paralogs for GNB2 Gene

Paralogs for GNB2 Gene

genes like me logo Genes that share paralogs with GNB2: view

Variants for GNB2 Gene

Sequence variations from dbSNP and Humsavar for GNB2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000302566 -- 100,676,586(+) CACTT(A/G)GTGGC intron-variant
rs1000360190 -- 100,672,421(+) AATAC(-/A)AAAAA upstream-variant-2KB
rs1001625407 -- 100,677,306(+) TGTCT(C/T)GTTTT intron-variant
rs1001849793 -- 100,679,068(+) GAGGC(-/AGGAGGT)GGAAA downstream-variant-500B, utr-variant-3-prime
rs1001863285 -- 100,673,312(+) GCGCT(G/T)CTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNB2 Gene

Variant ID Type Subtype PubMed ID
esv2664857 CNV deletion 23128226
esv2734888 CNV deletion 23290073
nsv1137588 CNV deletion 24896259
nsv365346 CNV deletion 16902084
nsv470381 CNV loss 18288195
nsv607933 CNV gain 21841781
nsv607934 CNV gain 21841781
nsv8184 CNV loss 18304495
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for GNB2 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNB2 Gene

Human Gene Mutation Database (HGMD)
GNB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB2 Gene

Disorders for GNB2 Gene

Relevant External Links for GNB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNB2

No disorders were found for GNB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNB2 Gene

Publications for GNB2 Gene

  1. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. (PMID: 16498633) Waragai M. … Ashizawa T. (J. Neurosci. Res. 2006) 3 4 22 64
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 64
  3. Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. (PMID: 26900580) Wagnon J.L. … Meisler M.H. (Ann. Clin. Transl. Neurol. 2016) 3 4 64
  4. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PMID: 19255495) Hill C. … Davey J. (Cell. Physiol. Biochem. 2009) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for GNB2 Gene

  • Addgene plasmids for GNB2

Sources for GNB2 Gene

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