Aliases for GNB2 Gene
- Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2 2 3
- Transducin Beta Chain 2 2 4
- Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit 2
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 2 2
- G Protein Subunit Beta-2 4
- Beta-2 Subunit 2
- G Protein 2
External Ids for GNB2 Gene
Previous GeneCards Identifiers for GNB2 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNB2 Gene
GNB2 (Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include signal transducer activity and calcium channel regulator activity. An important paralog of this gene is GNB4.
UniProtKB/Swiss-Prot for GNB2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.