Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GNB2 Gene

protein-coding   GIFtS: 62
GCID: GC07P100271

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 21 2     Beta-2 Subunit1
Transducin Beta Chain 21 2 3     G Protein1
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 21 2     G Protein, Beta-2 Subunit2
Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta
Subunit1 2
     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-22
G Protein Subunit Beta-22 3     

External Ids:    HGNC: 43981   Entrez Gene: 27832   Ensembl: ENSG000001723547   OMIM: 1393905   UniProtKB: P628793   

Export aliases for GNB2 gene to outside databases

Previous GC identifers: GC07P098805 GC07P099868 GC07P099882 GC07P099918 GC07P100110 GC07P094902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GNB2 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat
length polymorphism in its 5' UTR. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB2 Gene:
GNB2 (guanine nucleotide binding protein (G protein), beta polypeptide 2) is a protein-coding gene. GO annotations related to this gene include calcium channel regulator activity and signal transducer activity. An important paralog of this gene is GNB3.

UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNB2 gene promoter:
         Brachyury   USF-1:USF-2   Egr-4   GATA-1   RORalpha1   POU2F1   HOXA5   POU2F1a   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): GNB2 promoter sequence
   Search Chromatin IP Primers for GNB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

GNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100271:  view genomic region     (about GC identifiers)

Start:
100,271,154 bp from pter      End:
100,276,797 bp from pter
Size:
5,644 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,630,968-99,636,397     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2  
Size: 340 amino acids; 37331 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts
with ATXN10
Secondary accessions: P11016 P54312

Explore the universe of human proteins at neXtProt for GNB2: NX_P62879

Explore proteomics data for GNB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys57, Lys89, Lys209, Lys301
  • Modification sites at PhosphoSitePlus

  • See GNB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005264.2  
    ENSEMBL proteins: 
     ENSP00000305260   ENSP00000399904   ENSP00000401873   ENSP00000389391   ENSP00000390543  
     ENSP00000400286   ENSP00000377503   ENSP00000390077   ENSP00000413219   ENSP00000377501  
    Reactome Protein details: P62879

    GNB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GNB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GNB2
    GenScript Custom Purified and Recombinant Proteins Services for GNB2
    Novus Biologicals GNB2 Protein
    Novus Biologicals GNB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNB2 

    GNB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNB2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GNB2
    OriGene Custom Antibody Services for GNB2
    Novus Biologicals GNB2 Antibodies
    Abcam antibodies for GNB2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GNB2
    LSBio Antibodies in human, mouse, rat for GNB2

    GNB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GNB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P62879

    ProtoNet protein and cluster: P62879

    UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with GNB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB2_HUMAN, P62879
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB2:
    guanine nucleotide binding protein (G protein),beta,polypeptide 2,containing a CCG repeat in 5'utr

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS2902634
    GO:0004871signal transducer activity IEA--
    GO:0005246calcium channel regulator activity IEA--
    GO:0005515protein binding IPI16498633
    GO:0032403protein complex binding IDA--
         
    Find genes that share ontologies with GNB2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNB2:
    hsa-mir-92b-3p (MIRT040606), hsa-mir-16-5p (MIRT051197), hsa-mir-1 (MIRT023870), hsa-mir-23a-3p (MIRT050393), hsa-mir-331-3p (MIRT043396), hsa-mir-324-5p (MIRT043102), hsa-mir-744-5p (MIRT037626), hsa-mir-484 (MIRT041719)

    Block miRNA regulation of human, mouse, rat GNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNB2 (see all 28):
    hsa-miR-194* hsa-miR-142-3p hsa-miR-4265 hsa-miR-3194-5p hsa-miR-4328 hsa-miR-331-3p hsa-miR-374a hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGNB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNB2
    Predesigned siRNA for gene silencing in human, mouse, rat GNB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNB2

    Clone
    Products:
         
    OriGene clones in human, mouse for GNB2 (see all 8)
    OriGene ORF clones in mouse, rat for GNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB2 (NM_005273)
    Sino Biological Human cDNA Clone for GNB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GNB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GBB2_HUMAN, P62879: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0043234protein complex IEA--
    GO:0044297cell body IEA--
    GO:0048471perinuclear region of cytoplasm IDA16498633

    Find genes that share ontologies with GNB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GNB2 About   (see all 63)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58


    Find genes that share SuperPaths with GNB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNB2 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNB2 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    4 BioSystems Pathways for GNB2
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone


    Selected Reactome Pathways for GNB2 (see all 22)
        G alpha (12/13) signalling events
    G alpha (z) signalling events
    G-protein activation
    Ca2+ pathway
    Thromboxane signalling through TP receptor

    1 PharmGKB Pathway for GNB2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNB2) (see all 12):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Array including GNB2: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNB2 (P628792, 3 ENSP000003052604) via UniProtKB, MINT, STRING, and/or I2D (see all 195)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPNS1P046322, 3, ENSP000002465334MINT-63979 I2D: score=5 STRING: ENSP00000246533
    STAT5AP422292, 3, ENSP000003412084MINT-8272208 I2D: score=2 STRING: ENSP00000341208
    ANXA7P200732, 3MINT-8248417 I2D: score=2 
    CDKN1AP389362, 3MINT-8251926 I2D: score=2 
    FAM118BQ9BPY32, 3MINT-8255093 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS2902634
    GO:0007186G-protein coupled receptor signaling pathway TAS7649993
    GO:0007268synaptic transmission TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with GNB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GNB2 gene: 
    NM_005273.3  

    Unigene Cluster for GNB2:

    Guanine nucleotide binding protein (G protein), beta polypeptide 2
    Hs.185172  [show with all ESTs]
    Unigene Representative Sequence: BQ059784
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303210(uc003uwb.3) ENST00000451587 ENST00000436220 ENST00000424361
    ENST00000419828 ENST00000427895 ENST00000393926 ENST00000431068 ENST00000412215
    ENST00000393924 ENST00000480159 ENST00000469287(uc003uwf.3) ENST00000470354

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNB2 (see all 28):
    hsa-miR-194* hsa-miR-142-3p hsa-miR-4265 hsa-miR-3194-5p hsa-miR-4328 hsa-miR-331-3p hsa-miR-374a hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGNB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GNB2
    Predesigned siRNA for gene silencing in human, mouse, rat GNB2
    Clone
    Products:
         
    OriGene clones in human, mouse for GNB2 (see all 8)
    OriGene ORF clones in mouse, rat for GNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB2 (NM_005273)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB2
      QuantiTect SYBR Green Assays in human, mouse, rat GNB2
      QuantiFast Probe-based Assays in human, mouse, rat GNB2

    Additional mRNA sequence: 

    AF064853.1 AF501883.1 AK291592.1 BC010073.2 BC012348.1 BC068003.1 CR541729.1 M16538.1 
    M36429.1 

    Selected DOTS entries (see all 30):

    DT.95187921  DT.450702  DT.87079460  DT.40296586  DT.100796984  DT.91708506  DT.95173806  DT.100796979 
    DT.100767418  DT.95184938  DT.121042992  DT.100796982  DT.100800685  DT.87079459  DT.91764163  DT.95173804 
    DT.97815748  DT.99957512  DT.100796973  DT.100796974  DT.100797007  DT.91764159  DT.95153203  DT.95173803 

    Selected AceView cDNA sequences (see all 939):

    BQ674030 BM796535 BM014753 CR618808 BM910457 BM551569 BQ673624 BM982565 
    CR617794 BX117548 BM700116 CA430330 AF501883 BQ064710 BQ684849 AW136720 
    BM709258 CR610423 AW245961 CR622435 BQ919291 BI007401 BQ016948 BM128770 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GNB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                             
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for GNB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACACTAC
    GNB2 Expression
    About this image


    GNB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    GNB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.185172
        Pathway & Disease-focused RT2 Profiler PCR Array including GNB2: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB2
    QuantiTect SYBR Green Assays in human, mouse, rat GNB2
    QuantiFast Probe-based Assays in human, mouse, rat GNB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GNB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb21 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 92.65(n)1
    100(a)1
      5 (76.54 cM)5
    146931  NM_010312.41  NP_034442.11 
     1375281275 
    lizard
    (Anolis carolinensis)
    Reptilia GNB26
    guanine nucleotide binding protein (G protein), be...
    95(a)
    1 ↔ 1
    AAWZ02038342(920-12010)
    zebrafish
    (Danio rerio)
    Actinopterygii gnb21 guanine nucleotide binding protein (G protein), beta more 79.9(n)
    94.71(a)
      541370  NM_001013497.1  NP_001013515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;13F3 G-protein coupled receptor protein
    signaling pathway more
    81(a)
    (best of 2)
      13F16   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-13 guanine nucleotide-binding protein beta
    subunit
    85(a)   II(11743881-11747549)   --


    ENSEMBL Gene Tree for GNB2 (if available)
    TreeFam Gene Tree for GNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GNB2 gene
    GNB32  GNB12  WDR472  GNB52  GNB42  
    12 SIMAP similar genes for GNB2 using alignment to 7 protein entries:     GBB2_HUMAN (see all proteins):
    GNB4    GNB1    GNB3    GNB5    WDR61    POC1B
    PF20    WDR38    PRPF4    DAW1    FBXW7    POC1A

    Find genes that share paralogs with GNB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GNB2 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915650691,2
    --100269590(+) GGCTGC/TGTGTT 1 -- us2k10--------
    rs1828806161,2
    --100269594(+) GCGTGC/TTTTGA 1 -- us2k10--------
    rs1887420751,2
    --100269750(+) TGAGGC/TCTAGA 1 -- us2k10--------
    rs1178370111,2
    C,F--100269767(+) TTCTTG/TTCCCT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs2217881,2
    C,F--100270005(+) accagG/Cctggc 1 -- us2k14Minor allele frequency- C:0.50NA WA 8
    rs1482736491,2
    C--100270072(+) GTGGCA/GGGCGC 1 -- us2k10--------
    rs1928333911,2
    --100270166(+) CCACTA/GCACTT 1 -- us2k10--------
    rs1849493841,2
    --100270182(+) TGGGCA/GACAGA 1 -- us2k10--------
    rs102668211,2
    C,F,H--100270410(+) gagccG/Aaggag 1 -- us2k110Minor allele frequency- A:0.03NS NA WA 1472
    rs1876828171,2
    --100270441(+) CAATCA/GCGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNB2 (100271154 - 100276797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNB2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2664857CNV Deletion23128226
    nsv365346CNV Loss16902084
    nsv888792CNV Loss21882294
    nsv470381CNV Loss18288195
    nsv888791CNV Loss21882294
    nsv888779CNV Loss21882294
    dgv7401n71CNV Loss21882294
    dgv7399n71CNV Loss21882294
    nsv888795CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNB2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 139390    OMIM disorders: --


    Find genes that share disorders with GNB2           About GenesLikeMe


    Export disorders for GNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GNB2 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with GNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3 Gloeckner G.... Rosenthal A. (Genome Res. 1998)
    2. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. (PubMed id 16498633)1, 2, 9 Waragai M.... Ashizawa T. (J. Neurosci. Res. 2006)
    3. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C.... Davey J. (Cell. Physiol. Biochem. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. (PubMed id 3108879)1, 2 Fong H.K.W.... Simon M.I. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    6. A second form of the beta subunit of signal-transducing G proteins. (PubMed id 3114742)1, 2 Gao B.... Robishaw J.D. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    7. CCG repeats in cDNAs from human brain. (PubMed id 9921901)1, 9 Kleiderlein J.J.... Margolis R.L. (Hum. Genet. 1998)
    8. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    9. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2783 HGNC: 4398 AceView: GNB2 Ensembl:ENSG00000172354 euGenes: HUgn2783
    ECgene: GNB2 Kegg: 2783 H-InvDB: GNB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GNB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GNB2 gene:
    Search GeneIP for patents involving GNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of GNB2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GNB2   OriGene RNAi products in human, mouse, rat for GNB2  
     OriGene qPCR primer pairs and template standards for GNB2   OriGene Protein Over-expression Lysate for GNB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GNB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GNB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GNB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNB2   OriGene Custom Protein Services for GNB2  

     
     
     Block miRNA regulation of human, mouse, rat GNB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GNB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB2 Predesigned siRNA for gene silencing in human, mouse, rat GNB2
     QuantiFast Probe-based Assays in human, mouse, rat GNB2 QuantiTect SYBR Green Assays in human, mouse, rat GNB2
     PCR Arrays including human, mouse, rat GNB2 Search Chromatin IP Primers for GNB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB2  Search GeneGlobe Interaction Network for GNB2
     Regulatory tfbs in GNB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GNB2 GenScript cDNA clones with any tag delivered in your preferred vector for GNB2
     GenScript Custom Assay Services for GNB2 GenScript Custom overexpressing Cell Line Services for GNB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GNB2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GNB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GNB2 antibodies
     GNB2 proteins
     GNB2 lysates
     Antibodies for GNB2
     See all of Abcam's Antibodies, Kits and Proteins for GNB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GNB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB2
     SwitchGear 3'UTR luciferase reporter plasmids for GNB2
     SwitchGear Promoter luciferase reporter plasmids for GNB2
     ThermoFisher Antibodies for GNB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNB2
     LSBio Antibodies in human, mouse, rat for GNB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GNB2
      Search eBioscience for proteins for GNB2
      Search eBioscience for elisas for GNB2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNB2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4