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Aliases for GNB2 Gene

Aliases for GNB2 Gene

  • G Protein Subunit Beta 2 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2 2 5
  • Transducin Beta Chain 2 2 4
  • Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit 2
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 2 2
  • G Protein Subunit Beta-2 4
  • Beta-2 Subunit 2
  • G Protein 2

External Ids for GNB2 Gene

Previous GeneCards Identifiers for GNB2 Gene

  • GC07P098805
  • GC07P099868
  • GC07P099882
  • GC07P099918
  • GC07P100110
  • GC07P100271
  • GC07P094902

Summaries for GNB2 Gene

Entrez Gene Summary for GNB2 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNB2 Gene

GNB2 (G Protein Subunit Beta 2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTPase activity and protein complex binding. An important paralog of this gene is GNB4.

UniProtKB/Swiss-Prot for GNB2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNB2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNB2 Gene

Genomics for GNB2 Gene

Regulatory Elements for GNB2 Gene

Promoters for GNB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNB2 Gene

Chromosome:
7
Start:
100,673,531 bp from pter
End:
100,679,174 bp from pter
Size:
5,644 bases
Orientation:
Plus strand

Genomic View for GNB2 Gene

Genes around GNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNB2 Gene

Proteins for GNB2 Gene

  • Protein details for GNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62879-GBB2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
    Protein Accession:
    P62879
    Secondary Accessions:
    • B3KPU1
    • P11016
    • P54312

    Protein attributes for GNB2 Gene

    Size:
    340 amino acids
    Molecular mass:
    37331 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10.

    Alternative splice isoforms for GNB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNB2 Gene

Proteomics data for GNB2 Gene at MOPED

Post-translational modifications for GNB2 Gene

  • Ubiquitination at Lys 23, Lys 209, and Lys 301
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GNB2 Gene

Domains & Families for GNB2 Gene

Gene Families for GNB2 Gene

Graphical View of Domain Structure for InterPro Entry

P62879

UniProtKB/Swiss-Prot:

GBB2_HUMAN :
  • Belongs to the WD repeat G protein beta family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat G protein beta family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with GNB2: view

Function for GNB2 Gene

Molecular function for GNB2 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),beta,polypeptide 2,containing a CCG repeat in 5utr
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 2902634
genes like me logo Genes that share ontologies with GNB2: view
genes like me logo Genes that share phenotypes with GNB2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNB2 Gene

Localization for GNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNB2 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNB2 Gene COMPARTMENTS Subcellular localization image for GNB2 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0043234 protein complex IEA --
GO:0048471 perinuclear region of cytoplasm IDA 16498633
genes like me logo Genes that share ontologies with GNB2: view

Pathways & Interactions for GNB2 Gene

SuperPathways for GNB2 Gene

Superpath Contained pathways
1 Circadian entrainment
2 Development Angiotensin activation of ERK
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 G-protein activation
genes like me logo Genes that share pathways with GNB2: view

SIGNOR curated interactions for GNB2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006457 protein folding TAS --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7649993
genes like me logo Genes that share ontologies with GNB2: view

Drugs & Compounds for GNB2 Gene

(3) Drugs for GNB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNB2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4
genes like me logo Genes that share compounds with GNB2: view

Transcripts for GNB2 Gene

Unigene Clusters for GNB2 Gene

Guanine nucleotide binding protein (G protein), beta polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for GNB2 Gene

GeneLoc Exon Structure for
GNB2
ECgene alternative splicing isoforms for
GNB2

Expression for GNB2 Gene

mRNA expression in normal human tissues for GNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNB2 Gene

This gene is overexpressed in Whole Blood (x6.6).

Protein differential expression in normal tissues from HIPED for GNB2 Gene

This gene is overexpressed in Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNB2 Gene



SOURCE GeneReport for Unigene cluster for GNB2 Gene Hs.185172

genes like me logo Genes that share expression patterns with GNB2: view

Protein tissue co-expression partners for GNB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNB2 Gene

Orthologs for GNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNB2 35
  • 99.61 (n)
  • 100 (a)
GNB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNB2 36
  • 100 (a)
OneToOne
GNB2 35
  • 94.61 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia GNB2 35
  • 94.71 (n)
  • 100 (a)
GNB2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnb2 36
  • 100 (a)
OneToOne
Gnb2 16
Gnb2 35
  • 92.65 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia GNB2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gnb2 35
  • 92.16 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia GNB2 36
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gnb2 35
  • 79.9 (n)
  • 94.71 (a)
gnb2 36
  • 95 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005913 35
  • 72.35 (n)
  • 82.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gbeta13F 36
  • 81 (a)
OneToMany
Gbgr13F 37
  • 81 (a)
Gbgr76C 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea gpb-1 36
  • 85 (a)
OneToMany
gpb-1 37
  • 85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10536 36
  • 78 (a)
OneToMany
Species with no ortholog for GNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GNB2 Gene

ENSEMBL:
Gene Tree for GNB2 (if available)
TreeFam:
Gene Tree for GNB2 (if available)

Paralogs for GNB2 Gene

Paralogs for GNB2 Gene

genes like me logo Genes that share paralogs with GNB2: view

Variants for GNB2 Gene

Sequence variations from dbSNP and Humsavar for GNB2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs221788 -- 100,672,382(+) accag(C/G)ctggc upstream-variant-2KB
rs221789 -- 100,673,898(+) CGACC(C/T)CCGCC utr-variant-5-prime
rs2272573 -- 100,678,415(-) AAGGC(A/G)TAGCC reference, synonymous-codon
rs3840572 -- 100,673,284(-) CGAGC(-/C)GGGAG upstream-variant-2KB
rs62482252 -- 100,676,440(+) AGAAT(A/C)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNB2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888792 CNV Loss 21882294
dgv7401n71 CNV Loss 21882294
nsv888795 CNV Loss 21882294
esv2664857 CNV Deletion 23128226
nsv365346 CNV Loss 16902084

Variation tolerance for GNB2 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNB2 Gene

HapMap Linkage Disequilibrium report
GNB2
Human Gene Mutation Database (HGMD)
GNB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNB2 Gene

Disorders for GNB2 Gene

Relevant External Links for GNB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNB2

No disorders were found for GNB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNB2 Gene

Publications for GNB2 Gene

  1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 67
  2. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. (PMID: 16498633) Waragai M. … Ashizawa T. (J. Neurosci. Res. 2006) 3 23
  3. CCG repeats in cDNAs from human brain. (PMID: 9921901) Kleiderlein J.J. … Margolis R.L. (Hum. Genet. 1998) 3 23
  4. A Non-Canonical Function of GI^ as a Subunit of E3 Ligase in Targeting GRK2A Ubiquitylation. (PMID: 25982117) Zha Z. … Xiong Y. (Mol. Cell 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GNB2 Gene

Sources for GNB2 Gene

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