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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB2 Gene

protein-coding   GIFtS: 60
GCID: GC07P100271

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 21 2     Beta-2 Subunit1
Transducin Beta Chain 21 2 3     G Protein1
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 21 2     G Protein, Beta-2 Subunit2
Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta
Subunit1 2
     Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-22
G Protein Subunit Beta-22 3     

External Ids:    HGNC: 43981   Entrez Gene: 27832   Ensembl: ENSG000001723547   OMIM: 1393905   UniProtKB: P628793   

Export aliases for GNB2 gene to outside databases

Previous GC identifers: GC07P098805 GC07P099868 GC07P099882 GC07P099918 GC07P100110 GC07P094902


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNB2 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat
length polymorphism in its 5' UTR. (provided by RefSeq, Jul 2008)

GeneCards Summary for GNB2 Gene: 
GNB2 (guanine nucleotide binding protein (G protein), beta polypeptide 2) is a protein-coding gene. Diseases associated with GNB2 include endocarditis, and fanconi's anemia, and among its related super-pathways are G beta:gamma signalling through PLC beta and fMLP Pathway. GO annotations related to this gene include GTPase activity and calcium channel regulator activity. An important paralog of this gene is GNB3.

UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB2 gene promoter:
         Brachyury   USF-1:USF-2   Egr-4   GATA-1   RORalpha1   POU2F1   HOXA5   POU2F1a   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): GNB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

GNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100271:  view genomic region     (about GC identifiers)

Start:
100,271,154 bp from pter      End:
100,276,797 bp from pter
Size:
5,644 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,630,968-99,636,397     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2  
Size: 340 amino acids; 37331 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts
with ATXN10
Subcellular location: Cytoplasm, perinuclear region
Secondary accessions: P11016 P54312

Explore the universe of human proteins at neXtProt for GNB2: NX_P62879

Explore proteomics data for GNB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62879

  • GNB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNB2 Protein Expression
    REFSEQ proteins: NP_005264.2  
    ENSEMBL proteins: 
     ENSP00000305260   ENSP00000399904   ENSP00000401873   ENSP00000389391   ENSP00000390543  
     ENSP00000400286   ENSP00000377503   ENSP00000390077   ENSP00000413219   ENSP00000377501  
    Reactome Protein details: P62879
    Human Recombinant Protein Products for GNB2: 
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    Novus Biologicals GNB2 Protein
    Novus Biologicals GNB2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0043234protein complex IEA--
    GO:0044297cell body IEA--
    GO:0048471perinuclear region of cytoplasm IDA16498633

    GNB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P62879

    ProtoNet protein and cluster: P62879

    UniProtKB/Swiss-Prot: GBB2_HUMAN, P62879
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    GNB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB2_HUMAN, P62879
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB2:
    guanine nucleotide binding protein (G protein),beta,polypeptide 2,containing a CCG repeat in 5'utr

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS2902634
    GO:0004871signal transducer activity IEA--
    GO:0005246calcium channel regulator activity IEA--
    GO:0005515protein binding IPI16498633
    GO:0051020GTPase binding IPI19255495
         
    GNB2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNB2 
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    SwitchGear 3'UTR luciferase reporter plasmidGNB2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNB2 About   (see all 62)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PI3Kgamma0.89
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.61
    Prostacyclin signalling through prostacyclin receptor0.77
    Glucagon-type ligand receptors0.58
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    3Thromboxane signalling through TP receptor
    Signal amplification0.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    ADP signalling through P2Y purinoceptor 10.78
    Development Angiotensin signaling via beta-Arrestin0.40
    Thromboxane signalling through TP receptor0.78
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    5Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for GNB2 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB2 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNB2 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    3 BioSystems Pathways for GNB2
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    5/48        Reactome Pathways for GNB2 (see all 48)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    1 PharmGKB Pathway for GNB2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for GNB2) (see all 11):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GNB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for GNB2 (P628792, 3 ENSP000003052604) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPNS1P046322, 3, ENSP000002465334MINT-63979 I2D: score=5 STRING: ENSP00000246533
    ANXA7P200732, 3MINT-8248417 I2D: score=2 
    CDKN1AP389362, 3MINT-8251926 I2D: score=2 
    FAM118BQ9BPY32, 3MINT-8255093 I2D: score=2 
    GADD45AP245222, 3MINT-8255846 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS2902634
    GO:0007186G-protein coupled receptor signaling pathway TAS7649993
    GO:0007268synaptic transmission TAS--
    GO:0044281small molecule metabolic process TAS--

    GNB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNB2 / GBB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNB2 gene: 
    NM_005273.3  

    Unigene Cluster for GNB2:

    Guanine nucleotide binding protein (G protein), beta polypeptide 2
    Hs.185172  [show with all ESTs]
    Unigene Representative Sequence: BQ059784
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303210(uc003uwb.3) ENST00000451587 ENST00000436220 ENST00000424361
    ENST00000419828 ENST00000427895 ENST00000393926 ENST00000431068 ENST00000412215
    ENST00000393924 ENST00000480159 ENST00000469287(uc003uwf.3) ENST00000470354

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    Additional mRNA sequence: 

    AF064853.1 AF501883.1 AK291592.1 BC010073.2 BC012348.1 BC068003.1 CR541729.1 M16538.1 
    M36429.1 

    24/30 DOTS entries (see all 30):

    DT.95187921  DT.450702  DT.87079460  DT.40296586  DT.100796984  DT.91708506  DT.95173806  DT.100796979 
    DT.100767418  DT.95184938  DT.121042992  DT.100796982  DT.100800685  DT.87079459  DT.91764163  DT.95173804 
    DT.97815748  DT.99957512  DT.100796973  DT.100796974  DT.100797007  DT.91764159  DT.95153203  DT.95173803 

    24/939 AceView cDNA sequences (see all 939):

    BU957755 BG678016 BM460350 BM662314 CF140404 CR599855 BM781880 CR605173 
    BF902902 AW136720 BQ231705 AL039450 BQ651641 BM927552 BM982565 CR619728 
    BM784852 BU539857 AF501883 BU187142 BF431879 CR623391 BQ959094 BU735129 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GNB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                             
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for GNB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACACTAC
    GNB2 Expression
    About this image


    See GNB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB2

    SOURCE GeneReport for Unigene cluster: Hs.185172
        SABiosciences Expression via Pathway-Focused PCR Array including GNB2: 
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNB2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb21 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 92.65(n)1
    100(a)1
      5 (76.54 cM)5
    146931  NM_010312.41  NP_034442.11 
     1375281275 
    lizard
    (Anolis carolinensis)
    Reptilia GNB26
    Uncharacterized protein
    95(a)
    1 ↔ 1
    AAWZ02038342(920-12010)
    zebrafish
    (Danio rerio)
    Actinopterygii gnb21 guanine nucleotide binding protein (G protein), beta more 79.9(n)
    94.71(a)
      541370  NM_001013497.1  NP_001013515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;13F3 G-protein coupled receptor protein
    signaling pathway more
    81(a)
    (best of 2)
      13F16   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-13 guanine nucleotide-binding protein beta
    subunit
    85(a)   II(11743881-11747549)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE46
    G protein beta subunit, forms a dimer with Ste18p ...
    31(a)
    1 → many
    XV(742910-744181)


    ENSEMBL Gene Tree for GNB2 (if available)
    TreeFam Gene Tree for GNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB2 gene
    GNB32  GNB12  WDR472  GNB52  GNB42  
    12 SIMAP similar genes for GNB2 using alignment to 7 protein entries:     GBB2_HUMAN (see all proteins):
    GNB4    GNB1    GNB3    GNB5    WDR61    POC1B
    PF20    WDR38    PRPF4    DAW1    FBXW7    POC1A

    GNB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in GNB2 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915650691,2
    --100269590(+) GGCTGC/TGTGTT 1 -- us2k10--------
    rs1828806161,2
    --100269594(+) GCGTGC/TTTTGA 1 -- us2k10--------
    rs1887420751,2
    --100269750(+) TGAGGC/TCTAGA 1 -- us2k10--------
    rs1178370111,2
    C,F--100269767(+) TTCTTG/TTCCCT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs2217881,2
    C,F--100270005(+) accagG/Cctggc 1 -- us2k14Minor allele frequency- C:0.50NA WA 8
    rs1482736491,2
    C--100270072(+) GTGGCA/GGGCGC 1 -- us2k10--------
    rs1928333911,2
    --100270166(+) CCACTA/GCACTT 1 -- us2k10--------
    rs1849493841,2
    --100270182(+) TGGGCA/GACAGA 1 -- us2k10--------
    rs102668211,2
    C,F,H--100270410(+) gagccG/Aaggag 1 -- us2k110Minor allele frequency- A:0.03NS NA WA 1472
    rs1876828171,2
    --100270441(+) CAATCA/GCGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNB2 (100271154 - 100276797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for GNB2 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2664857CNV Deletion23128226
    nsv365346CNV Loss16902084
    nsv888792CNV Loss21882294
    nsv470381CNV Loss18288195
    nsv888791CNV Loss21882294
    nsv888779CNV Loss21882294
    dgv7401n71CNV Loss21882294
    dgv7399n71CNV Loss21882294
    nsv888795CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139390    OMIM disorders: --

    13 diseases for GNB2:    About MalaCards
    endocarditis    fanconi's anemia    huntington's disease    anemia
    neuropathy    schizophrenia    colorectal cancer    prostate cancer
    prostatitis    gastric cancer    alzheimer's disease    breast cancer
    neuronitis


    GNB2 for disorders           About GeneDecksing


    Export disorders for GNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB2 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with GNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3 Gloeckner G.... Rosenthal A. (1998)
    2. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. (PubMed id 16498633)1, 2, 9 Waragai M.... Ashizawa T. (2006)
    3. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C....Davey J. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. (PubMed id 3108879)1, 2 Fong H.K.W.... Simon M.I. (1987)
    6. A second form of the beta subunit of signal-transducing G proteins. (PubMed id 3114742)1, 2 Gao B.... Robishaw J.D. (1987)
    7. CCG repeats in cDNAs from human brain. (PubMed id 9921901)1, 9 Kleiderlein J.J.... Margolis R.L. (1998)
    8. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    9. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    10. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2783 HGNC: 4398 AceView: GNB2 Ensembl:ENSG00000172354 euGenes: HUgn2783
    ECgene: GNB2 Kegg: 2783 H-InvDB: GNB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNB2 gene:
    Search GeneIP for patents involving GNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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