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GNB1 Gene

protein-coding   GIFtS: 67
GCID: GC01M001748

Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide...

  See GNB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 11 2
Transducin Beta Chain 12 3
Beta Subunit, Signal-Transducing Proteins GS/GI2
G Protein, Beta-1 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-12

External Ids:    HGNC: 43961   Entrez Gene: 27822   Ensembl: ENSG000000783697   OMIM: 1393805   UniProtKB: P628733   

Export aliases for GNB1 gene to outside databases

Previous GC identifers: GC01M001274 GC01M001521 GC01M001585 GC01M001665 GC01M000993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNB1 Gene:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and
effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families
of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as
well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for GNB1 Gene:
GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1) is a protein-coding gene. Diseases associated with GNB1 include hemiplegic migraine, and familial hemiplegic migraine. GO annotations related to this gene include GTPase binding and signal transducer activity. An important paralog of this gene is GNB2.

UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
of GDP by GTP, and for G protein-effector interaction

summary for GNB1 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNB1 gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNB1 promoter sequence
   Search Chromatin IP Primers for GNB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

GNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001748:  view genomic region     (about GC identifiers)

Start:
1,716,725 bp from pter      End:
1,822,526 bp from pter
Size:
105,802 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1  
Size: 340 amino acids; 37377 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The
heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus)
1 PDB 3D structure from and Proteopedia for GNB1:
4KFM (3D)    
Secondary accessions: B1AJZ7 P04697 P04901

Explore the universe of human proteins at neXtProt for GNB1: NX_P62873

Explore proteomics data for GNB1 at MOPED

Post-translational modifications: 

  • Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate
    transfer onto GDP (By similarity)1
  • Ubiquitination2 at Lys15, Lys23, Lys57, Lys89, Lys127, Lys209, Lys280, Lys301
  • Modification sites at PhosphoSitePlus

  • See GNB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269467.1  NP_001269468.1  NP_002065.1  

    ENSEMBL proteins: 
     ENSP00000367872   ENSP00000399741   ENSP00000392765   ENSP00000416651  
    Reactome Protein details: P62873

    GNB1 Human Recombinant Protein Products:

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    Novus Biologicals GNB1 Protein
    Novus Biologicals GNB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNB1 

     
    antibodies-online proteins for GNB1 (2 products) 

     
    antibodies-online peptides for GNB1

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    antibodies-online antibodies for GNB1 (36 products) 

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    antibodies-online kits for GNB1 (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P62873

    ProtoNet protein and cluster: P62873

    UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with GNB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBB1_HUMAN, P62873
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement
    of GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB1:
    guanine nucleotide binding protein (G protein),beta,polypeptide 1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA1543505
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI16782902
    GO:0032403protein complex binding IDA--
    GO:0051020GTPase binding IPI19255495
         
    Find genes that share ontologies with GNB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GNB1:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnb1):
     behavior/neurological  cellular  embryogenesis  mortality/aging  nervous system 
     respiratory system 

    Find genes that share phenotypes with GNB1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GNB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNB1:
    hsa-mir-17-5p (MIRT051020), hsa-mir-101-3p (MIRT027365), hsa-mir-1 (MIRT023929), hsa-mir-589-3p (MIRT040502), hsa-let-7b-5p (MIRT052049), hsa-mir-106a-5p (MIRT048352), hsa-mir-16-5p (MIRT031864), hsa-mir-103a-3p (MIRT027151)

    Block miRNA regulation of human, mouse, rat GNB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNB1 (see all 28):
    hsa-miR-4291 hsa-miR-502-5p hsa-miR-607 hsa-miR-3673 hsa-miR-139-5p hsa-miR-4263 hsa-miR-485-3p hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmidGNB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNB1

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for GNB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB1 (NM_002074)
    Sino Biological Human cDNA Clone for GNB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ----
    GO:0001917photoreceptor inner segment IEA--
    GO:0005622intracellular ISS--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005834heterotrimeric G-protein complex IDA1543505

    Find genes that share ontologies with GNB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNB1 About   (see all 80)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    G beta-gamma signalling through PI3Kgamma0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 10.79
    Glucagon-type ligand receptors0.61
    2The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    Visual signal transduction- Rods0.51
    Activation of the phototransduction cascade0.00
    Phototransduction0.51
    3fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    4Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    Chemotaxis CXCR4 signaling pathway0.48
    5Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40


    Find genes that share SuperPaths with GNB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNB1 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNB1 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for GNB1 (see all 17)
        Myometrial Relaxation and Contraction Pathways
    Estrogen signaling pathway
    G Protein Signaling Pathways
    Nicotine Activity on Dopaminergic Neurons
    Calcium Regulation in the Cardiac Cell


    Selected Reactome Pathways for GNB1 (see all 25)
        G alpha (12/13) signalling events
    Inactivation, recovery and regulation of the phototransduction cascade
    G alpha (z) signalling events
    Olfactory Signaling Pathway
    G-protein activation

    2 PharmGKB Pathways for GNB1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNB1) (see all 14):
        Ras signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Array including GNB1: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNB1 (P628731, 2, 3 ENSP000003678724) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49116 I2D: score=2 
    NCF2P198781, 2, 3, ENSP000003565054EBI-357130,EBI-489611 MINT-7135210 MINT-7135236 I2D: score=1 STRING: ENSP00000356505
    GNAI2P048992, 3, ENSP000003129994MINT-7135221 I2D: score=1 STRING: ENSP00000312999
    MAP3K3Q997592, 3, ENSP000003549274MINT-48439 I2D: score=2 STRING: ENSP00000354927
    CACNA1BQ009753, ENSP000002775494I2D: score=2 STRING: ENSP00000277549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS3095147
    GO:0007165signal transduction TAS7649993
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway ISS--

    Find genes that share ontologies with GNB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GNB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for GNB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FARNESYL-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNB1 gene (3 alternative transcripts): 
    NM_001282538.1  NM_001282539.1  NM_002074.4  

    Unigene Cluster for GNB1:

    Guanine nucleotide binding protein (G protein), beta polypeptide 1
    Hs.430425  [show with all ESTs]
    Unigene Representative Sequence: NM_002074
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378609(uc001aif.3 uc009vky.3) ENST00000461893 ENST00000471354
    ENST00000439272 ENST00000434686 ENST00000437146 ENST00000607589 ENST00000472614

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    Selected qRT-PCR Assays for microRNAs that regulate GNB1 (see all 28):
    hsa-miR-4291 hsa-miR-502-5p hsa-miR-607 hsa-miR-3673 hsa-miR-139-5p hsa-miR-4263 hsa-miR-485-3p hsa-miR-938
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNB1 (NM_002074)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB1
    Primer
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    OriGene qPCR primer pairs and template standards for GNB1
    OriGene qSTAR qPCR primer pairs in human, mouse for GNB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNB1
      QuantiTect SYBR Green Assays in human, mouse, rat GNB1
      QuantiFast Probe-based Assays in human, mouse, rat GNB1

    Additional mRNA sequence: 

    AF070597.1 AF070603.1 AF501882.1 AK096614.1 AK122949.1 AK312614.1 BC004186.2 BC005888.2 
    BC008991.1 BC114618.1 BT007305.1 CR456784.1 M36430.1 

    Selected DOTS entries (see all 45):

    DT.454208  DT.100888224  DT.100039426  DT.92016370  DT.92411260  DT.100888249  DT.121355192  DT.100888223 
    DT.40275341  DT.121355210  DT.121355194  DT.120545  DT.436291  DT.75121609  DT.100888219  DT.97765262 
    DT.95169843  DT.100039424  DT.100888221  DT.121355278  DT.121355345  DT.91776167  DT.91831230  DT.95072649 

    Selected AceView cDNA sequences (see all 1164):

    BM011487 BQ897057 BE740105 BG678317 AA721135 BG481136 CR591784 N25713 
    CA426275 BQ881467 BE253956 BQ958631 CB111123 BG029607 BQ639474 BM461774 
    BE254466 T95175 BQ438007 BM875308 AU124287 BM770951 AW168888 W21506 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNB1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -                 -                                                                                                         
    SP2:                                                                                -     -                             -           -               
    SP3:                                                                                -     -                             -                           
    SP4:                                                                                                                    -           -               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for GNB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTAGAAAT
    GNB1 Expression
    About this image


    GNB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    GNB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.430425
        Pathway & Disease-focused RT2 Profiler PCR Array including GNB1: 
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNB1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnb11 , 5 guanine nucleotide binding protein (G protein), beta more1, 5 90.2(n)1
    100(a)1
      4 (86.17 cM)5
    146881  NM_001160016.11  NP_001153488.11 
     1554913645 
    chicken
    (Gallus gallus)
    Aves GNB11 guanine nucleotide binding protein (G protein), beta more 82.55(n)
    97.94(a)
      419402  NM_001012835.2  NP_001012853.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNB16
    guanine nucleotide binding protein (G protein), be...
    82(a)
    1 ↔ 1
    GL344230.1(23295-44057)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48402 X.laevis mRNA for beta 1 subunit of heterotrimeric more 83.96(n)    X86969.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056708.12   -- 87.17(n)    BC056708.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G&bgr;13F3
    Gbeta13F1
    G-protein coupled receptor protein
    signaling pathway more3
    G protein beta-subunit 13F1
    83(a)
    (best of 2)3
    70.39(n)1
    83.53(a)1
      13F163
    325441  NM_080351.61  NP_525090.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gpb-11 , 3 guanine nucleotide-binding protein beta
    subunit3
    gpb-11
    85(a)3
    70.2(n)1
    85.88(a)1
      II(11743881-11747549)3
    1748031  NM_001267383.11  NP_001254312.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AGB11 AGB1 51.38(n)
    48.22(a)
      829597  NM_001085022.1  NP_001078491.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06692001 Os03g0669200 53.86(n)
    52.98(a)
      4333680  NM_001057398.2  NP_001050863.2 


    ENSEMBL Gene Tree for GNB1 (if available)
    TreeFam Gene Tree for GNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNB1 gene
    GNB22  GNB32  WDR472  GNB52  GNB42  
    7 SIMAP similar genes for GNB1 using alignment to 6 protein entries:     GBB1_HUMAN (see all proteins):
    GNB2    GNB3    GNB4    GNB5    NLE1    SNRNP40
    WDSUB1

    Find genes that share paralogs with GNB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNB1 (see all 2282)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906248531,2
    C--1716228(+) AGTGGA/GTGGTT 1 -- ds50010--------
    rs1148852571,2
    F--1716414(+) GGAGGG/AAAATG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1159983121,2
    F--1716418(+) GGAAAT/AGGCAG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1163101951,2
    F--1716421(+) AATGGC/GAGAGG 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs729090691,2
    C,F--1716531(+) CTGCTG/AGCCTG 1 -- ds50013Minor allele frequency- A:0.05WA 122
    rs1495244231,2
    --1716565(+) CCTCCA/GAGGAG 1 -- ds50010--------
    rs1822359421,2
    --1716607(+) GTGGCA/GGCCAT 1 -- ds50010--------
    rs1386457891,2
    --1716637(+) AGGCCC/TGTCAG 1 -- ds50010--------
    rs1168093711,2
    F--1716678(+) GCGGGC/TGCGTT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1860269421,2
    C--1716679(+) CGGGCA/GCGTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GNB1 (1716725 - 1822526 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNB1 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750029CNV Deletion23290073
    esv2666680CNV Deletion23128226
    esv2619193CNV Deletion19546169
    esv2658596CNV Deletion23128226
    nsv482957CNV Loss15286789
    nsv871204CNV Loss21882294
    nsv834335CNV Loss17160897
    nsv871954CNV Loss21882294
    nsv871560CNV Loss21882294
    dgv34n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for GNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139380    OMIM disorders: --

    2 diseases for GNB1:    
    About MalaCards
    hemiplegic migraine    familial hemiplegic migraine


    Find genes that share disorders with GNB1           About GenesLikeMe

    1 Novoseek inferred disease relationship for GNB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 58.3 1 17167406 (1)

    Genetic Association Database (GAD): GNB1
    Human Genome Epidemiology (HuGE) Navigator: GNB1 (3 documents)

    Export disorders for GNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNB1 gene, integrated from 10 sources (see all 133):
    (articles sorted by number of sources associating them with GNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. (PubMed id 17167406)1, 4, 9 Mylvaganam G.H....Dryja T.P. (Mol. Vis. 2006)
    2. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C.... Davey J. (Cell. Physiol. Biochem. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. (PubMed id 14512443)1, 2 Niu J.... Voyno-Yasenetskaya T. (Circ. Res. 2003)
    5. Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (PubMed id 3095147)1, 2 Codina J.... Birnbaumer L. (FEBS Lett. 1986)
    6. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PubMed id 17356515)1, 9 Gao Y.Q....Farber D.B. (Mol. Vis. 2007)
    7. Selection of Phototransduction Genes in Homo sapiens. (PubMed id 23868983)1 Christopher M....AbrA moff M.D. (amp 2013)
    8. Interaction of G-protein I^I^ complex with chromatin modulates GPCR-dependent gene regulation. (PubMed id 23326349)1 Bhatnagar A....Karnik S.S. (PLoS ONE 2013)
    9. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    10. IGF-1 activates a cilium-localized noncanonical GI^I^ signaling pathway that regulates cell-cycle progression. (PubMed id 23954591)1 Yeh C....Sung C.H. (Dev. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2782 HGNC: 4396 AceView: GNB1 Ensembl:ENSG00000078369 euGenes: HUgn2782
    ECgene: GNB1 Kegg: 2782 H-InvDB: GNB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GNB1 gene:
    Search GeneIP for patents involving GNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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