Aliases for GNB1 Gene
External Ids for GNB1 Gene
Previous GeneCards Identifiers for GNB1 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for GNB1 Gene
GNB1 (G Protein Subunit Beta 1) is a Protein Coding gene. Diseases associated with GNB1 include Mechanical Strabismus and Pathologic Nystagmus. Among its related pathways are Thromboxane signalling through TP receptor and Inwardly rectifying K+ channels. GO annotations related to this gene include GTPase activity and protein complex binding. An important paralog of this gene is GNB4.
UniProtKB/Swiss-Prot for GNB1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.