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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNB1 Gene

protein-coding   GIFtS: 67
GCID: GC01M001748

guanine nucleotide binding protein (G protein), beta polypeptide...
 Explore 19 diseases affiliated with
GNB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GNB1    

Aliases
for GNB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 11 2
Transducin Beta Chain 12 3
Beta Subunit, Signal-Transducing Proteins GS/GI2
G Protein, Beta-1 Subunit2
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 12
Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-12

External Ids:    HGNC: 43961   Entrez Gene: 27822   Ensembl: ENSG000000783697   OMIM: 1393805   UniProtKB: P628733   

Export aliases for GNB1 gene to outside databases

Previous GC identifers: GC01M001274 GC01M001521 GC01M001585 GC01M001665 GC01M000993


Summaries
for GNB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNB1:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector
proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related
genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of
certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
GDP by GTP, and for G protein-effector interaction

summary for GNB1:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB1


Genomic Views
for GNB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB1 gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

GNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001748:  view genomic region     (about GC identifiers)

Start:
 1,716,725 bp from pter      End:
 1,822,502 bp from pter
Size:
 105,778 bases      Orientation:
 minus strand

Proteins
for GNB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1  
Size: 340 amino acids; 37377 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer
formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus)
Secondary accessions: B1AJZ7 P04697 P04901

Explore the universe of human proteins at neXtProt for GNB1: NX_P62873

Post-translational modifications:

  • Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate
    • transfer onto GDP (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62873

    • GNB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002065.1  
    ENSEMBL proteins: 
     ENSP00000367872   ENSP00000399741   ENSP00000392765   ENSP00000416651   ENSP00000367869  
     ENSP00000416870  
    Reactome Protein details: P62873
    Human Recombinant Protein Products: 
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    Novus Biologicals GNB1 Protein
    Novus Biologicals GNB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ----
    GO:0001917photoreceptor inner segment IEA--
    GO:0005622intracellular ISS--
    GO:0005624membrane fraction ----
    GO:0005834heterotrimeric G-protein complex IDA1543505


    GNB1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GNB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNB1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001632 Gprotein_B

    Graphical View of Domain Structure for InterPro Entry P62873

    ProtoNet protein and cluster: P62873

    UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    Function
    for GNB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
    GDP by GTP, and for G protein-effector interaction

         Genatlas biochemistry entry for GNB1:
    guanine nucleotide binding protein (G protein),beta,polypeptide 1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNB1
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB1 (see all 28):
    hsa-miR-4291 hsa-miR-502-5p hsa-miR-607 hsa-miR-3673 hsa-miR-139-5p hsa-miR-4263 hsa-miR-485-3p hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmid: GNB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB1 (see all 6)
    OriGene siRNA: GNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GNB1

    Clone
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    GenScript: all cDNA clones in your preferred vector: GNB1 (NM_002074)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB1 

    Cell Line
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    Search LifeMap BioReagents cell lines for GNB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNB1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding ----
    GO:0003924GTPase activity IDA1543505
    GO:0004871signal transducer activity IEA--
    GO:0031702type 1 angiotensin receptor binding ----
    GO:0051020GTPase binding IPI19255495


    GNB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GNB1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gnb1):
     behavior/neurological  cellular  embryogenesis  mortality/aging  nervous system 
     respiratory system 

    GNB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GNB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/81 super-pathways (see all 81) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G beta:gamma signalling through PLC beta
    8/13 pathways (see all 13)
    		G beta:gamma signalling through PLC beta1.00
    		Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.55
    		Presynaptic function of Kainate receptors0.95
    		G-protein activation0.55
    		Prostacyclin signalling through prostacyclin receptor0.77
    		Glucagon-type ligand receptors0.52
    		G-protein beta:gamma signalling0.71
    		G-Protein Signaling through Tubby Protein0.38
    2Development Angiotensin activation of ERK
    8/9 pathways (see all 9)
    		Development Angiotensin activation of ERK1.00
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development_EDNRB signaling0.54
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    3Development_A3 receptor signaling
    		Development_A3 receptor signaling1.00
    		Development A1 receptor signaling0.65
    		Development A3 receptor signaling1.00
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		Development_A1 receptor signaling0.65
    		G-protein signaling G-Protein alpha-q signaling cascades0.53
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Development_Dopamine D2 receptor transactivation of EGFR
    		Development_Dopamine D2 receptor transactivation of EGFR1.00
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		Development Dopamine D2 receptor transactivation of EGFR1.00
    		Chemotaxis_CXCR4 signaling pathway0.48
    		Development_Alpha-2 adrenergic receptor activation of ERK0.66
    		Chemotaxis CXCR4 signaling pathway0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/31 EMD Millipore Pathways for GNB1 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNB1 (see all 71)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    JNK Pathway
    ERK5 Signaling

    5/34 GeneGo (Thomson Reuters) Pathways for GNB1 (see all 34)
        Signal transduction cAMP signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/16 BioSystems Pathways for GNB1 (see all 16) 
        Nicotine Activity on Dopaminergic Neurons
    Calcium Regulation in the Cardiac Cell
    Estrogen signaling pathway
    G Protein Signaling Pathways
    Myometrial Relaxation and Contraction Pathways

    5/49        Reactome Pathways for GNB1 (see all 49)
        G alpha (12/13) signalling events
    Platelet homeostasis
    G protein gated Potassium channels
    G alpha (z) signalling events
    Inwardly rectifying K+ channels

    2 PharmGKB Pathways for GNB1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    5         Kegg Pathways  (Kegg details for GNB1):
        Chemokine signaling pathway
    Glutamatergic synapse
    Cholinergic synapse
    Taste transduction
    Phototransduction


    GNB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for GNB1 (P628732, 3 ENSP000003678724) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF2P198782, 3, ENSP000003565054MINT-7135210 MINT-7135236 I2D: score=1 STRING: ENSP00000356505
    RIPK3Q9Y5722, 3MINT-49116 I2D: score=2 
    GNAI2P048992, 3, ENSP000003129994MINT-7135221 I2D: score=1 STRING: ENSP00000312999
    MAP3K3Q997592, 3, ENSP000003549274MINT-48439 I2D: score=2 STRING: ENSP00000354927
    CACNA1BQ009753, ENSP000002775494I2D: score=2 STRING: ENSP00000277549
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process TAS3095147
    GO:0007165signal transduction TAS8717044
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway ISS--


    GNB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    GRK2iGRK2 inhibitory polypeptide. Gbetagamma antagonist[148505-03-7]

    3 HMDB Compounds for GNB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for GNB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FARNESYL-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about GNB1 / GBB1 

    Transcripts
    for GNB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNB1 gene: 
    NM_002074.3  

    Unigene Cluster for GNB1:

    Guanine nucleotide binding protein (G protein), beta polypeptide 1
    Hs.430425  [show with all ESTs]
    Unigene Representative Sequence: NM_002074
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378609(uc001aif.3 uc009vky.3) ENST00000461893 ENST00000471354
    ENST00000439272 ENST00000434686 ENST00000437146 ENST00000472614 ENST00000378606
    ENST00000455156

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate GNB1 (see all 28):
    hsa-miR-4291 hsa-miR-502-5p hsa-miR-607 hsa-miR-3673 hsa-miR-139-5p hsa-miR-4263 hsa-miR-485-3p hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmid: GNB1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNB1 (see all 6)
    OriGene siRNA: GNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNB1
    Clone
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    GenScript: all cDNA clones in your preferred vector: GNB1 (NM_002074)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNB1 
    Primer
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    Additional cDNA sequence: 

    AF070597.1 AF070603.1 AF501882.1 AK096614.1 AK122949.1 AK312614.1 BC004186.2 BC005888.2 
    BC008991.1 BC114618.1 BC127205.1 BT007305.1 CR456784.1 M36430.1 

    24/51 DOTS entries (see all 51):

    DT.454208  DT.100888224  DT.100039426  DT.92016370  DT.100888223  DT.92411260  DT.100888249  DT.121355192 
    DT.121355210  DT.40275341  DT.121355194  DT.95072649  DT.120545  DT.436291  DT.75121609  DT.100888219 
    DT.95219226  DT.97765262  DT.100888239  DT.95169843  DT.100039424  DT.100888221  DT.121355278  DT.121355317 

    24/1164 AceView cDNA sequences (see all 1164):

    W67904 CA314476 N25713 BQ027213 AA417140 BU155463 BU186462 BE902898 
    AV728634 BM697139 AW515627 BM668653 AW410846 AI832354 BG025873 BQ931451 
    BU502467 AA308747 BQ005828 AI497771 BM835951 BU541875 BT007305 BQ052114 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -                 -                                                                                                         
    SP2:                                                                                -     -                             -           -               
    SP3:                                                                                -     -                             -                           
    SP4:                                                                                                                    -           -               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for GNB1

    Expression
    for GNB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTAGAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GNB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GNB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNB1

    SOURCE GeneReport for Unigene cluster: Hs.430425
        SABiosciences Expression via Pathway-Focused PCR Array including GNB1: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNB1
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    In Situ
    Assay Products:     
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    Orthologs
    for GNB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNB1 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNB11 guanine nucleotide binding protein (G protein), beta more 81.95(n)
    97.23(a)    		   419402  NM_001012835.1  NP_001012853.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GNB16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL344230.1(23295-43145)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.48402 X.laevis mRNA for beta 1 subunit of heterotrimeric more 83.96(n)    X86969.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056708.12   -- 87.17(n)    BC056708.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta G&bgr;13F3
    Gbeta13F1    		 G-protein coupled receptor protein signaling
    pathway more3
    G protein beta-subunit 13F1    		 83(a)
    (best of 2)3
    70.39(n)1
    83.53(a)1    		   13F163
    325441  NM_206739.11  NP_996462.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea gpb-11 , 3 guanine nucleotide-binding protein beta
    subunit3
    Protein GPB-11    		 85(a)3
    70.2(n)1
    85.88(a)1    		   II(11743881-11747549)3
    1748031  NM_064107.61  NP_496508.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ELK46
    		 guanine nucleotide-binding protein subunit beta
    		 42(a)
    		 1 → many
    		 4(16477106-16479528)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 WD domain, G-beta repeat domain containing protein...
    		 43(a)
    		 1 → many
    		 3(26391617-26399638)


    ENSEMBL Gene Tree for GNB1 (if available)
    TreeFam Gene Tree for GNB1 (if available) 

    Paralogs
    for GNB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNB1 gene
    GNB22  GNB32  WDR472  GNB42  GNB52  
    11 SIMAP similar genes for GNB1 using alignment to 7 protein entries:     GBB1_HUMAN (see all proteins):
    GNB2    GNB4    GNB3    GNB5    NLE1    WDSUB1
    WDR61    PF20    POC1B    SNRNP40    SPAG16

    GNB1 for paralogs           About GeneDecksing



    Genomic Variants
    for GNB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1798 NCBI SNPs in GNB1 are shown (see all 1798)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1906248531,2
    		--1716228(+) AGTGGA/GTGGTT 1 -- ds50010--------
    rs1148852571,2
    		F,--1716414(+) GGAGGG/AAAATG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1159983121,2
    		F,--1716418(+) GGAAAT/AGGCAG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1163101951,2
    		F,--1716421(+) AATGGC/GAGAGG 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs729090691,2
    		C,F,--1716531(+) CTGCTG/AGCCTG 1 -- ds50013Minor allele frequency- A:0.05WA 122
    rs1495244231,2
    		--1716565(+) CCTCCA/GAGGAG 1 -- ds50010--------
    rs1822359421,2
    		--1716607(+) GTGGCA/GGCCAT 1 -- ds50010--------
    rs1386457891,2
    		--1716637(+) AGGCCC/TGTCAG 1 -- ds50010--------
    rs1168093711,2
    		--1716678(+) GCGGGC/TGCGTT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1860269421,2
    		--1716679(+) CGGGCA/GCGTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GNB1 (1716725 - 1822502 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for GNB1
         4 CNVs: 0002 97251 84002 3276
         2 Indels: 33196 74287

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    Disorders / Diseases
    for GNB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNB1 for disorders           About GeneDecksing

    OMIM gene information: 139380    OMIM disorders: --

    19 diseases for GNB1:    About MalaCards
    autosomal recessive nonsyndromic deafness    hemiplegic migraine    familial hemiplegic migraine    nonsyndromic deafness
    retinitis pigmentosa    migraine    agammaglobulinemia    retinitis
    thrombosis    hepatocellular carcinoma    asthma    neuroblastoma
    schizophrenia    melanoma    carcinoma    neuronitis
    huntington's disease    colorectal cancer    breast cancer

    1 Novoseek disease relationship for GNB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 58.3 1 17167406 (1)

    Genetic Association Database (GAD): GNB1
    Human Genome Epidemiology (HuGE) Navigator: GNB1 (3 documents)

    Export disorders for GNB1 gene to outside databases

    Publications
    for GNB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNB1 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with GNB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C....Davey J. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. (PubMed id 14512443)1, 2 Niu J.... Voyno-Yasenetskaya T. (2003)
    4. Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (PubMed id 3095147)1, 2 Codina J.... Birnbaumer L. (1986)
    5. Association of the Asn306Ser variant of the SP4 trans cription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PubMed id 17356515)1, 9 Gao Y.Q....Farber D.B. (2007)
    6. A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. (PubMed id 17167406)1, 9 Mylvaganam G.H....Dryja T.P. (2006)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for GNB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GNB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2782 HGNC: 4396 AceView: GNB1 Ensembl:ENSG00000078369 euGenes: HUgn2782
    ECgene: GNB1 Kegg: 2782 H-InvDB: GNB1

    Other Databases showing GNB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNB1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for GNB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNB1 gene:
    Search GeneIP for patents involving GNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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