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Aliases for GNAZ Gene

Aliases for GNAZ Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide 2 3
  • G(X) Alpha Chain 3 4
  • Gz-Alpha 3 4
  • Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha 3
  • Transducin Alpha 3

External Ids for GNAZ Gene

Previous GeneCards Identifiers for GNAZ Gene

  • GC22P020136
  • GC22P021737
  • GC22P021728
  • GC22P023413
  • GC22P006380

Summaries for GNAZ Gene

Entrez Gene Summary for GNAZ Gene

  • The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNAZ Gene

GNAZ (Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide) is a Protein Coding gene. Diseases associated with GNAZ include autosomal dominant congenital stationary night blindness and pertussis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAZ Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Tocris Summary for GNAZ Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAZ Gene

Genomics for GNAZ Gene

Regulatory Elements for GNAZ Gene

Genomic Location for GNAZ Gene

Start:
23,070,361 bp from pter
End:
23,125,037 bp from pter
Size:
54,677 bases
Orientation:
Plus strand

Genomic View for GNAZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAZ Gene

Proteins for GNAZ Gene

  • Protein details for GNAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19086-GNAZ_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(z) subunit alpha
    Protein Accession:
    P19086
    Secondary Accessions:
    • B2R6C1
    • Q4QRJ6

    Protein attributes for GNAZ Gene

    Size:
    355 amino acids
    Molecular mass:
    40924 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site

neXtProt entry for GNAZ Gene

Proteomics data for GNAZ Gene at MOPED

Post-translational modifications for GNAZ Gene

  • Ubiquitination at Lys189
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAZ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNAZ Gene

Domains for GNAZ Gene

Graphical View of Domain Structure for InterPro Entry

P19086

UniProtKB/Swiss-Prot:

GNAZ_HUMAN :
  • P19086
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAZ: view

No data available for Gene Families for GNAZ Gene

Function for GNAZ Gene

Molecular function for GNAZ Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha,z polypeptide
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Gene Ontology (GO) - Molecular Function for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005057 receptor signaling protein activity TAS 2456569
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAZ: view
genes like me logo Genes that share phenotypes with GNAZ: view

Animal Models for GNAZ Gene

MGI Knock Outs for GNAZ:

miRNA for GNAZ Gene

miRTarBase miRNAs that target GNAZ

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNAZ Gene

Localization for GNAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAZ Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAZ Gene COMPARTMENTS Subcellular localization image for GNAZ gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
cytosol 3
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 2117645
GO:0005783 endoplasmic reticulum TAS 2117645
GO:0005829 cytosol IEA --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNAZ: view

Pathways for GNAZ Gene

genes like me logo Genes that share pathways with GNAZ: view

Interacting Proteins for GNAZ Gene

Selected Interacting proteins: P19086-GNAZ_HUMAN for GNAZ Gene via I2D

Gene Ontology (GO) - Biological Process for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007186 G-protein coupled receptor signaling pathway TAS 3129724
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNAZ: view

Compounds for GNAZ Gene

(5) Tocris Compounds for GNAZ Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNAZ Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(7) Novoseek inferred chemical compound relationships for GNAZ Gene

Compound -log(P) Hits PubMed IDs
metarhodopsin ii 78.2 1
gtp 71.7 5
gdp 59 2
cgmp 57.2 2
1,1,1 trichloroethane 55.8 1
genes like me logo Genes that share compounds with GNAZ: view

Transcripts for GNAZ Gene

mRNA/cDNA for GNAZ Gene

(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNAZ Gene

Guanine nucleotide binding protein (G protein), alpha z polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAZ Gene

No ASD Table

Relevant External Links for GNAZ Gene

GeneLoc Exon Structure for
GNAZ
ECgene alternative splicing isoforms for
GNAZ

Expression for GNAZ Gene

mRNA expression in normal human tissues for GNAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GNAZ Gene

SOURCE GeneReport for Unigene cluster for GNAZ Gene Hs.584760

genes like me logo Genes that share expressions with GNAZ: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAZ Gene

Orthologs for GNAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAZ 35
  • 99.62 (n)
  • 100 (a)
GNAZ 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAZ 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAZ 35
  • 93.33 (n)
  • 99.15 (a)
GNAZ 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnaz 35
  • 92.21 (n)
  • 98.31 (a)
Gnaz 16
Gnaz 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAZ 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAZ 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnaz 35
  • 91.64 (n)
  • 98.31 (a)
chicken
(Gallus gallus)
Aves GNAZ 35
  • 82.25 (n)
  • 97.18 (a)
GNAZ 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAZ 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnaz 35
  • 81.69 (n)
  • 96.34 (a)
zebrafish
(Danio rerio)
Actinopterygii gnaz 35
  • 80.25 (n)
  • 93.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea odr-3 37
  • 44 (a)
gpa-14 37
  • 32 (a)
gpa-6 37
  • 37 (a)
gpa-4 37
  • 50 (a)
gpa-15 37
  • 41 (a)
gpa-3 37
  • 47 (a)
gpa-9 37
  • 34 (a)
gpa-7 37
  • 52 (a)
gpa-11 37
  • 38 (a)
gpa-2 37
  • 42 (a)
gpa-5 37
  • 32 (a)
Species with no ortholog for GNAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAZ Gene

ENSEMBL:
Gene Tree for GNAZ (if available)
TreeFam:
Gene Tree for GNAZ (if available)

Paralogs for GNAZ Gene

Selected SIMAP similar genes for GNAZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNAZ: view

Variants for GNAZ Gene

Structural Variations from Database of Genomic Variants (DGV) for GNAZ Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
esv34158 CNV Loss 18971310
dgv4902n71 CNV Loss 21882294
esv24055 CNV Loss 19812545
dgv19e24 CNV Loss 17666407
nsv914577 CNV Loss 21882294
nsv3573 CNV Loss 18451855
nsv525485 CNV Loss 19592680
esv33363 CNV Gain+Loss 17666407

Relevant External Links for GNAZ Gene

HapMap Linkage Disequilibrium report
GNAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GNAZ Gene

Disorders for GNAZ Gene

(1) Novoseek inferred disease relationships for GNAZ Gene

Disease -log(P) Hits PubMed IDs
night blindness 61.8 3

Relevant External Links for GNAZ

Genetic Association Database (GAD)
GNAZ
Human Genome Epidemiology (HuGE) Navigator
GNAZ
genes like me logo Genes that share disorders with GNAZ: view

No data available for UniProtKB/Swiss-Prot for GNAZ Gene

Publications for GNAZ Gene

  1. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (PMID: 1908722) Gagnon A.W. … Brass L.F. (Blood 1991) 3 4 23
  2. Characterization of the human gene for Gx alpha, a pertussis toxin- insensitive regulatory GTP-binding protein. (PMID: 2115889) Matsuoka M. … Kaziro Y. (J. Biol. Chem. 1990) 2 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. (PMID: 3129724) Fong H.K.W. … Simon M.I. (Proc. Natl. Acad. Sci. U.S.A. 1988) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GNAZ Gene

Sources for GNAZ Gene

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