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Aliases for GNAZ Gene

Aliases for GNAZ Gene

  • G Protein Subunit Alpha Z 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide 2 3
  • G(X) Alpha Chain 3 4
  • Gz-Alpha 3 4
  • Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha 3
  • Transducin Alpha 3

External Ids for GNAZ Gene

Previous GeneCards Identifiers for GNAZ Gene

  • GC22P020136
  • GC22P021737
  • GC22P021728
  • GC22P023413
  • GC22P006380

Summaries for GNAZ Gene

Entrez Gene Summary for GNAZ Gene

  • The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNAZ Gene

GNAZ (G Protein Subunit Alpha Z) is a Protein Coding gene. Diseases associated with GNAZ include Pertussis and Autosomal Dominant Congenital Stationary Night Blindness. Among its related pathways are Development Endothelin-1/EDNRA signaling and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAI1.

UniProtKB/Swiss-Prot for GNAZ Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNAZ Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNAZ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAZ Gene

Genomics for GNAZ Gene

Regulatory Elements for GNAZ Gene

Enhancers for GNAZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G023098 1.3 Ensembl ENCODE dbSUPER 19.5 +28.8 28760 2.7 HDAC1 ATF1 TBL1XR1 KLF13 ZNF263 MCM3 HCFC1 HDAC8 MEF2D TFDP1 GNAZ IGLV5-52 RSPH14 RAB36 ENSG00000234630 ENSG00000272779 BCR GC22P023109 PIR32987 PIR59194
GH22G023034 1.2 Ensembl ENCODE 17.8 -34.3 -34269 3.1 ATF1 E2F7 ZNF143 FOS KDM4B ZNF263 KAT8 CREB3 SMARCA4 ETV4 GNAZ ENSG00000272973 ZDHHC8P1 LOC105372948
GH22G024010 1.4 ENCODE dbSUPER 13.8 +941.3 941282 2.5 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZDHHC8P1 SUSD2 GNAZ ZNF70 ENSG00000272973 SNRPD3 GGTLC4P DDT BCR CABIN1
GH22G023175 1 ENCODE dbSUPER 13.9 +106.7 106654 2.4 CTCF BCOR ZMYM3 KLF17 SALL2 ZNF664 ZNF121 ZNF366 POLR2A ADNP GNAZ ENSG00000272973 BCR ZDHHC8P1 LOC100420267
GH22G023109 1.1 ENCODE dbSUPER 12.3 +40.4 40444 2.1 HDAC1 FOXA2 BMI1 KLF13 CREM MCM3 ZBTB2 MCM5 JUNB HDAC8 GNAZ PIR59194 GC22P023109 PIR32987
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNAZ on UCSC Golden Path with GeneCards custom track

Promoters for GNAZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144186 239 1201 ATF1 PKNOX1 CREB3L1 ARID4B ZNF2 GLIS2 FOS KLF13 KDM4B SP3

Genomic Location for GNAZ Gene

Chromosome:
22
Start:
23,070,361 bp from pter
End:
23,125,037 bp from pter
Size:
54,677 bases
Orientation:
Plus strand

Genomic View for GNAZ Gene

Genes around GNAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAZ Gene

Proteins for GNAZ Gene

  • Protein details for GNAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19086-GNAZ_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(z) subunit alpha
    Protein Accession:
    P19086
    Secondary Accessions:
    • B2R6C1
    • Q4QRJ6

    Protein attributes for GNAZ Gene

    Size:
    355 amino acids
    Molecular mass:
    40924 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNAZ Gene

Post-translational modifications for GNAZ Gene

  • Ubiquitination at isoforms=189
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNAZ Gene

Domains & Families for GNAZ Gene

Gene Families for GNAZ Gene

Graphical View of Domain Structure for InterPro Entry

P19086

UniProtKB/Swiss-Prot:

GNAZ_HUMAN :
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAZ: view

Function for GNAZ Gene

Molecular function for GNAZ Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha,z polypeptide
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Gene Ontology (GO) - Molecular Function for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity IEA --
GO:0005057 signal transducer activity, downstream of receptor TAS 2456569
GO:0005525 GTP binding TAS --
genes like me logo Genes that share ontologies with GNAZ: view
genes like me logo Genes that share phenotypes with GNAZ: view

Animal Models for GNAZ Gene

MGI Knock Outs for GNAZ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNAZ Gene

Localization for GNAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAZ Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNAZ gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 4
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 2117645
GO:0005783 endoplasmic reticulum TAS 2117645
GO:0005829 cytosol IEA --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNAZ: view

Pathways & Interactions for GNAZ Gene

genes like me logo Genes that share pathways with GNAZ: view

Interacting Proteins for GNAZ Gene

SIGNOR curated interactions for GNAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 3129724
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNAZ: view

Drugs & Compounds for GNAZ Gene

(6) Drugs for GNAZ Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for GNAZ Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNAZ Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNAZ: view

Transcripts for GNAZ Gene

mRNA/cDNA for GNAZ Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNAZ Gene

Guanine nucleotide binding protein (G protein), alpha z polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNAZ Gene

No ASD Table

Relevant External Links for GNAZ Gene

GeneLoc Exon Structure for
GNAZ
ECgene alternative splicing isoforms for
GNAZ

Expression for GNAZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5), Frontal cortex (13.1), Brain (9.6), Platelet (8.8), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GNAZ Gene



Protein tissue co-expression partners for GNAZ Gene

NURSA nuclear receptor signaling pathways regulating expression of GNAZ Gene:

GNAZ

SOURCE GeneReport for Unigene cluster for GNAZ Gene:

Hs.584760

Evidence on tissue expression from TISSUES for GNAZ Gene

  • Nervous system(4.9)
  • Eye(2)
genes like me logo Genes that share expression patterns with GNAZ: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNAZ Gene

Orthologs for GNAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAZ 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia GNAZ 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAZ 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAZ 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAZ 34 35
  • 93.33 (n)
mouse
(Mus musculus)
Mammalia Gnaz 34 16 35
  • 92.21 (n)
rat
(Rattus norvegicus)
Mammalia Gnaz 34
  • 91.64 (n)
chicken
(Gallus gallus)
Aves GNAZ 34 35
  • 82.25 (n)
lizard
(Anolis carolinensis)
Reptilia GNAZ 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnaz 34
  • 81.69 (n)
zebrafish
(Danio rerio)
Actinopterygii gnaz 34
  • 80.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 35
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpa-7 36
  • 52 (a)
gpa-4 36
  • 50 (a)
gpa-3 36
  • 47 (a)
odr-3 36
  • 44 (a)
gpa-2 36
  • 42 (a)
gpa-15 36
  • 41 (a)
gpa-11 36
  • 38 (a)
gpa-6 36
  • 37 (a)
gpa-9 36
  • 34 (a)
gpa-14 36
  • 32 (a)
gpa-5 36
  • 32 (a)
Species where no ortholog for GNAZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAZ Gene

ENSEMBL:
Gene Tree for GNAZ (if available)
TreeFam:
Gene Tree for GNAZ (if available)

Paralogs for GNAZ Gene

Paralogs for GNAZ Gene

(19) SIMAP similar genes for GNAZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNAZ: view

Variants for GNAZ Gene

Sequence variations from dbSNP and Humsavar for GNAZ Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000029772 -- 23,101,005(+) ATGGC(A/G)TGTTG intron-variant, utr-variant-3-prime
rs1000101083 -- 23,114,480(+) CAGCC(C/G)CCAGA intron-variant, utr-variant-3-prime
rs1000271390 -- 23,071,717(+) GCCTC(A/C/G)GGAGG intron-variant, upstream-variant-2KB
rs1000344093 -- 23,086,903(+) AGGTC(C/T)AGGCC intron-variant
rs1000369440 -- 23,070,719(+) CCCTC(-/AG)GGGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNAZ Gene

Variant ID Type Subtype PubMed ID
dgv19e24 CNV loss 17666407
dgv8037n54 CNV gain 21841781
esv24055 CNV loss 19812545
esv33363 CNV gain+loss 17666407
esv34158 CNV loss 18971310
esv3647390 CNV gain 21293372
esv3647392 CNV gain 21293372
esv3893457 CNV gain 25118596
nsv1061433 CNV gain+loss 25217958
nsv1066891 CNV gain 25217958
nsv1071782 CNV deletion 25765185
nsv1124862 CNV duplication 24896259
nsv3573 CNV deletion 18451855
nsv521695 CNV loss 19592680
nsv525485 CNV loss 19592680
nsv588512 CNV loss 21841781
nsv588589 CNV gain 21841781
nsv588593 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv953050 CNV deletion 24416366

Variation tolerance for GNAZ Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNAZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNAZ Gene

Disorders for GNAZ Gene

MalaCards: The human disease database

(5) MalaCards diseases for GNAZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pertussis
  • bordetella infection
autosomal dominant congenital stationary night blindness
  • adcsnb
congenital stationary night blindness
  • congenital essential nyctalopia
achromatopsia
  • achm
deafness, autosomal recessive 12
  • deafness, autosomal recessive 12, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search GNAZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNAZ

Genetic Association Database (GAD)
GNAZ
Human Genome Epidemiology (HuGE) Navigator
GNAZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNAZ
genes like me logo Genes that share disorders with GNAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNAZ Gene

Publications for GNAZ Gene

  1. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (PMID: 1908722) Gagnon A.W. … Brass L.F. (Blood 1991) 3 4 22 64
  2. Characterization of the human gene for Gx alpha, a pertussis toxin- insensitive regulatory GTP-binding protein. (PMID: 2115889) Matsuoka M. … Kaziro Y. (J. Biol. Chem. 1990) 2 3 4 64
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GNAZ Gene

Sources for GNAZ Gene

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