Aliases for GNAZ Gene
External Ids for GNAZ Gene
Previous GeneCards Identifiers for GNAZ Gene
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNAZ Gene
GNAZ (Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide) is a Protein Coding gene. Diseases associated with GNAZ include autosomal dominant congenital stationary night blindness and achromatopsia. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNAZ Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.