Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAZ Gene

protein-coding   GIFtS: 62
GCID: GC22P023413

guanine nucleotide binding protein (G protein), alpha z...

 Explore 22 diseases affiliated with
GNAZ via our new
 Human Malady Compendium 
Biological research products
for GNAZ
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide1 2
G(X) Alpha Chain2 3
Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha2
Gz-Alpha1
Transducin Alpha2
Gz-Alpha1

External Ids:    HGNC: 43951   Entrez Gene: 27812   Ensembl: ENSG000001282667   OMIM: 1391605   UniProtKB: P190863   

Export aliases for GNAZ gene to outside databases

Previous GC identifers: GC22P020136 GC22P021737 GC22P021728 GC22P006380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNAZ:
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis
toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and
endolymphatic cochlear fluids. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GNAZ_HUMAN, P19086
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNAZ:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAZ


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAZ gene promoter:
         TBP   AP-4   Cdc5   C/EBPalpha   CHOP-10   HEN1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAZ promoter sequence
   Search SABiosciences Chromatin IP Primers for GNAZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.1-q11.2

GNAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAZ gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023413:  view genomic region     (about GC identifiers)

Start:
23,412,540 bp from pter      End:
23,467,224 bp from pter
Size:
54,685 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNAZ_HUMAN, P19086 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(z) subunit alpha  
Size: 355 amino acids; 40924 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide
binding site
Subcellular location: Membrane; Lipid-anchor
Secondary accessions: B2R6C1 Q4QRJ6

Explore the universe of human proteins at neXtProt for GNAZ: NX_P19086

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19086

  • GNAZ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002064.1  
    ENSEMBL proteins: 
     ENSP00000248996  
    Reactome Protein details: P19086
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GNAZ
    OriGene Custom Protein Services for GNAZ 
    GenScript Custom Purified and Recombinant Proteins Services for GNAZ
    Novus Biologicals GNAZ Protein
    Novus Biologicals GNAZ Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for GNAZ
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS2117645
    GO:0005783endoplasmic reticulum TAS2117645
    GO:0005829cytosol IEA--
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--


    GNAZ for ontologies           About GeneDecksing



    GNAZ Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GNAZ  (G-alpha(z))
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GNAZ 
    GenScript Custom Superior Antibodies Services for GNAZ
    Novus Biologicals GNAZ Antibodies
    Abcam antibodies for GNAZ 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for GNAZ

    Assay Products for GNAZ: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNAZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GNAZ for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I

    Graphical View of Domain Structure for InterPro Entry P19086

    ProtoNet protein and cluster: P19086

    2 Blocks protein families:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAZ_HUMAN, P19086
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GNAZ_HUMAN, P19086
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

         Genatlas biochemistry entry for GNAZ:
    guanine nucleotide binding protein (G protein),alpha,z polypeptide

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: GNAZ
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAZ
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAZ (see all 35):
    hsa-miR-21* hsa-miR-3678-3p hsa-miR-2052 hsa-miR-4307 hsa-miR-411 hsa-miR-513a-5p hsa-miR-1276 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidGNAZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAZ (see all 7)
    OriGene shRNA RFP: GNAZ
    OriGene siRNA: GNAZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNAZ

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GNAZ (NM_002073)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAZ 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNAZ
    Search LifeMap BioReagents cell lines for GNAZ

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAZ

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005057receptor signaling protein activity TAS2456569
    GO:0005525GTP binding IEA--
    GO:0031683G-protein beta/gamma-subunit complex binding IBA--


    GNAZ for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Gnaztm1Iah for GNAZ
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnaz):
     behavior/neurological  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     integument  mortality/aging  nervous system  reproductive system 

    GNAZ for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/49 super-pathways (see all 49About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    Development Angiotensin activation of ERK1.00
    Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    Development_Angiotensin activation of ERK0.98
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    Development_ACM2 and ACM4 activation of ERK0.74
    Development_EDNRB signaling0.54
    Development ACM2 and ACM4 activation of ERK0.74
    Development EDNRB signaling0.54
    2Development_Dopamine D2 receptor transactivation of EGFR
    Development_Dopamine D2 receptor transactivation of EGFR1.00
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    Development Dopamine D2 receptor transactivation of EGFR1.00
    Chemotaxis_CXCR4 signaling pathway0.48
    Development_Alpha-2 adrenergic receptor activation of ERK0.66
    Chemotaxis CXCR4 signaling pathway0.48
    3G Protein Signaling Pathways
    G Protein Signaling Pathways1.00
    Signal transduction_PKA signaling0.23
    Signal transduction cAMP signaling0.44
    Signal transduction PKA signaling0.23
    Signal transduction_cAMP signaling0.44
    4G-Beta Gamma Signaling
    G-Beta Gamma Signaling1.00
    Relaxin Pathway0.32
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.22
    CRHR Pathway0.44
    5Development_A3 receptor signaling
    Development_A3 receptor signaling1.00
    Development_A1 receptor signaling0.65
    Development A3 receptor signaling1.00
    Development A1 receptor signaling0.65

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/23 EMD Millipore Pathways for GNAZ (see all 23)
        Chemotaxis CXCR4 signaling pathway
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Integrin inside-out signaling
    Development G-Proteins mediated regulation MARK-ERK signaling

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAZ (see all 38)
        Molecular Mechanisms of Cancer
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    ERK5 Signaling
    Rho Family GTPases

    2 Cell Signaling Technology (CST) Pathways for GNAZ
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/25 GeneGo (Thomson Reuters) Pathways for GNAZ (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/9 BioSystems Pathways for GNAZ (see all 9
        G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    S1P2 pathway
    S1P5 pathway

    5/8        Reactome Pathways for GNAZ (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    G alpha (z) signalling events
    Opioid Signalling
    G-protein activation


    1         Kegg Pathway  (Kegg details for GNAZ):
        Long-term depression


    GNAZ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNAZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for GNAZ (P190863 ENSP000002489964) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS10O436653, ENSP000003580994I2D: score=3 STRING: ENSP00000358099
    NMT1P304193, ENSP000002589604I2D: score=2 STRING: ENSP00000258960
    OPRD1P411433, ENSP000002349614I2D: score=2 STRING: ENSP00000234961
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    RGS20O760813, ENSP000002973134I2D: score=2 STRING: ENSP00000297313
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS2117645
    GO:0007186G-protein coupled receptor signaling pathway TAS3129724
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--


    GNAZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNAZ for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNAZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Mastoparan XG protein activator peptide[72093-22-2]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]

    3 HMDB Compounds for GNAZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    7 Novoseek chemical compound relationships for GNAZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metarhodopsin ii 78.2 1 8052635 (1)
    gtp 71.7 6 8395213 (1), 8185603 (1), 8900174 (1), 9083000 (1) (see all 5)
    gdp 59 2 16815918 (1), 8774882 (1)
    cgmp 57.2 2 9852093 (1), 7768919 (1)
    1,1,1 trichloroethane 55.8 1 16103122 (1)
    arachidonic acid 0 2 9359846 (1), 1606965 (1)
    calcium 0 1 12975484 (1)

    Search CenterWatch for drugs/clinical trials and news about GNAZ 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNAZ gene: 
    NM_002073.2  

    Unigene Cluster for GNAZ:

    Guanine nucleotide binding protein (G protein), alpha z polypeptide
    Hs.584760  [show with all ESTs]
    Unigene Representative Sequence: BC037333
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248996(uc002zwu.1) ENST00000492538 ENST00000479571

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: GNAZ
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAZ
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAZ (see all 35):
    hsa-miR-21* hsa-miR-3678-3p hsa-miR-2052 hsa-miR-4307 hsa-miR-411 hsa-miR-513a-5p hsa-miR-1276 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidGNAZ 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAZ (see all 7)
    OriGene shRNA RFP: GNAZ
    OriGene siRNA: GNAZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAZ
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GNAZ (NM_002073)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAZ 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAZ
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNAZ
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAZ
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAZ

    Additional cDNA sequence: 

    AF493899.1 AK293653.1 AK309397.1 AK312519.1 BC026342.1 BC037333.1 BC078163.1 BC096828.1 
    CR456495.1 J03260.1 

    10 DOTS entries:

    DT.100728447  DT.114734  DT.100680712  DT.120677021  DT.100753158  DT.100773110  DT.120677198  DT.87015846 
    DT.100756359  DT.91651812 

    1 AceView cDNA sequence:

    AK126747 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGGAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GNAZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAZ

    SOURCE GeneReport for Unigene cluster: Hs.584760
        SABiosciences Expression via Pathway-Focused PCR Array including GNAZ: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAZ
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNAZ
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAZ
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNAZ gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GNAZ1 guanine nucleotide binding protein (G protein), alpha more 82.25(n)
    97.18(a)
      770226  XM_001232444.1  XP_001232445.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAZ6
    --
    96(a)
    1 ↔ 1
    AAWZ02037698(642-1379)
    zebrafish
    (Danio rerio)
    Actinopterygii gnaz1 guanine nucleotide binding protein (G protein), alpha more 80.14(n)
    93.47(a)
      564915  XM_001921887.1  XP_001921922.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A6
    G protein alphai subunit 65A
    61(a)
    possible ortholog
    3L(6965850-6973153)
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-73 guanine nucleotide-binding protein 52(a)
    (best of 11)
      IV(10404194-10408441)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XLG16
    XLG26
    (see all 4)
    extra-large GTP-binding protein 2
    (see all 4)
    9(a)
    8(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2(9995478-9999122)
    4(16441179-16445005)
    rice
    (Oryza sativa)
    Liliopsida XA76
    --
    (see all 5)
    G-protein alpha subunit, putative, expressed
    (see all 5)
    27(a)
    16(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    5(15552385-15556024)
    10(1125704-1130461)


    ENSEMBL Gene Tree for GNAZ (if available)
    TreeFam Gene Tree for GNAZ (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAZ gene
    GNAQ2  GNA142  GNA112  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA152  GNAI22  GNA122  GNAI12  GNAO12  
    18 SIMAP similar genes for GNAZ using alignment to 3 protein entries:     GNAZ_HUMAN (see all proteins):
    DKFZp686O0962    GNAI3    GNAI2    GNAT3    GNAT2    GNAI1
    GNAO1    GNAT1    GNA14    GNA11    GNAQ    GNA12
    GNA13    GNA15    GNAL    GNAS    GSA    WUGSC

    GNAZ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/881 NCBI SNPs in GNAZ are shown (see all 881    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568337761,2
    C,--6378530(+) GATAGC/TCTCAC 1 -- int12Minor allele frequency- T:0.17WA 120
    rs1853610921,2
    --23410867(+) CTGCAA/GTGGAA 2 -- int1 us2k10--------
    rs130549041,2
    C,F,H,--23410918(+) CTATAT/AACATT 2 -- int1 us2k1 tfbs318Minor allele frequency- A:0.15NS EA NA WA 2342
    rs412775271,2
    --23411052(+) CCTGAC/TACAGC 2 -- us2k1 int10--------
    rs1477688131,2
    --23411083(+) CACAAA/CGGGTA 2 -- int1 us2k10--------
    rs1423539801,2
    --23411347(+) ACATGC/TCCCTG 2 -- us2k1 int10--------
    rs1814027621,2
    --23411602(+) GTCTTC/TTAAGC 2 -- us2k1 int10--------
    rs1488358121,2
    --23411639(+) AGGTCC/TACAGA 2 -- int1 us2k10--------
    rs734011201,2
    C,--23411670(+) AGAATC/TTTGCA 2 -- int1 us2k11Minor allele frequency- T:0.50WA 2
    rs37883371,2
    C,F,A,H,--23412017(+) CAGGAA/GAGCAG 2 -- int1 us2k122Minor allele frequency- G:0.49EA NS NA WA CSA 2526

    HapMap Linkage Disequilibrium report for GNAZ (23412540 - 23467224 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GNAZ
         1 CNV: 48008
         2 Indels: 73775 11198

    1 SABiosciences Cancer Mutation PCR Assay for GNAZ:
    Cosmic IdAA Change
    107624p.D151N
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAZ
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GNAZ for disorders           About GeneDecksing

    OMIM gene information: 139160    OMIM disorders: --

    20/22 diseases for GNAZ (see all 22):    About MalaCards
    pertussis    congenital stationary night blindness    night blindness    pseudosarcomatous fibromatosis
    graft versus host disease    enuresis    achromatopsia    dilated cardiomyopathy
    blindness    retinal degeneration    fibromatosis    fainting
    cardiomyopathy    cholera    retinitis    pharyngitis
    immunodeficiency    melanoma    neuronitis    chronic graft versus host disease

    1 Novoseek disease relationship for GNAZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    night blindness 61.8 3 10702259 (2), 16793893 (1)

    Human Genome Epidemiology (HuGE) Navigator: GNAZ (2 documents)

    Export disorders for GNAZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAZ gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with GNAZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene for Gx alpha, a pertussis toxin- insensitive regulatory GTP-binding protein. (PubMed id 2115889)1, 2, 3 Matsuoka M.... Kaziro Y. (1990)
    2. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (PubMed id 1908722)1, 2, 9 Gagnon A.W....Brass L.F. (1991)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. (PubMed id 3129724)1, 2 Fong H.K.W.... Simon M.I. (1988)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Novel somatic mutations in heterotrimeric G proteins in melanoma. (PubMed id 20424519)1 CA!rdenas-Navia L.I....Samuels Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2781 HGNC: 4395 AceView: GNAZ.1 Ensembl:ENSG00000128266 euGenes: HUgn2781
    ECgene: GNAZ Kegg: 2781 H-InvDB: GNAZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNAZ gene:
    Search GeneIP for patents involving GNAZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for GNAZ  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAZ   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAZ  
     OriGene Protein Over-expression Lysate for GNAZ   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GNAZ   OriGene 3'-UTR Clone for GNAZ  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAZ  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNAZ   OriGene Custom Protein Services for GNAZ  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNAZ
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAZ
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAZ
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAZ
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAZ
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAZ
     GenScript Custom Purified and Recombinant Proteins Services for GNAZ GenScript cDNA clones with any tag delivered in your preferred vector for GNAZ
     GenScript Custom Assay Services for GNAZ GenScript Custom Superior Antibodies Services for GNAZ
     GenScript Custom overexpressing Cell Line Services for GNAZ CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GNAZ  (G-alpha(z))

     Regulatory tfbs in GNAZ promoter
     Search Chromatin IP Primers for GNAZ
     RT2 qPCR Primer Assay in human, mouse, rat GNAZ
     Search GNC Networks for GNAZ
     SABiosciences PCR Arrays including human, mouse, rat GNAZ
     Tocris compounds for GNAZ
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GNAZ antibodies
     GNAZ proteins
     GNAZ lysates
     Antibodies for GNAZ
     See all of Abcam's Antibodies, Kits and Proteins for GNAZ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GNAZ




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for GNAZ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAZ
     SwitchGear 3'UTR luciferase reporter plasmids for GNAZ
     SwitchGear Promoter luciferase reporter plasmids for GNAZ
     ThermoFisher Antibodies for GNAZ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAZ
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNAZ gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4