Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GNAZ Gene

Aliases for GNAZ Gene

  • G Protein Subunit Alpha Z 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide 2 3 5
  • G(X) Alpha Chain 3 4
  • Gz-Alpha 3 4
  • Transducin Alpha 3

External Ids for GNAZ Gene

Previous GeneCards Identifiers for GNAZ Gene

  • GC22P020136
  • GC22P021737
  • GC22P021728
  • GC22P023413
  • GC22P006380

Summaries for GNAZ Gene

Entrez Gene Summary for GNAZ Gene

  • The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNAZ Gene

GNAZ (G Protein Subunit Alpha Z) is a Protein Coding gene. Diseases associated with GNAZ include Pertussis and Autosomal Dominant Congenital Stationary Night Blindness. Among its related pathways are EphB-EphrinB Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAZ Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNAZ Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNAZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAZ Gene

Genomics for GNAZ Gene

Regulatory Elements for GNAZ Gene

Enhancers for GNAZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNAZ on UCSC Golden Path with GeneCards custom track

Promoters for GNAZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNAZ on UCSC Golden Path with GeneCards custom track

Genomic Location for GNAZ Gene

23,070,361 bp from pter
23,125,037 bp from pter
54,677 bases
Plus strand

Genomic View for GNAZ Gene

Genes around GNAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAZ Gene

Proteins for GNAZ Gene

  • Protein details for GNAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(z) subunit alpha
    Protein Accession:
    Secondary Accessions:
    • B2R6C1
    • Q4QRJ6

    Protein attributes for GNAZ Gene

    355 amino acids
    Molecular mass:
    40924 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNAZ Gene

Proteomics data for GNAZ Gene at MOPED

Post-translational modifications for GNAZ Gene

  • Ubiquitination at Lys 189
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNAZ Gene

Domains & Families for GNAZ Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAZ: view

No data available for Gene Families for GNAZ Gene

Function for GNAZ Gene

Molecular function for GNAZ Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha,z polypeptide
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Gene Ontology (GO) - Molecular Function for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005057 receptor signaling protein activity TAS 2456569
GO:0031683 G-protein beta/gamma-subunit complex binding IEA,IBA --
genes like me logo Genes that share ontologies with GNAZ: view
genes like me logo Genes that share phenotypes with GNAZ: view

Animal Models for GNAZ Gene

MGI Knock Outs for GNAZ:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNAZ Gene

Localization for GNAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAZ Gene

Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for GNAZ Gene COMPARTMENTS Subcellular localization image for GNAZ gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with GNAZ: view

Pathways & Interactions for GNAZ Gene

genes like me logo Genes that share pathways with GNAZ: view

Interacting Proteins for GNAZ Gene

Selected Interacting proteins: P19086-GNAZ_HUMAN for GNAZ Gene via I2D

SIGNOR curated interactions for GNAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNAZ: view

Drugs & Compounds for GNAZ Gene

(6) Drugs for GNAZ Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for GNAZ Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
Mastoparan X
NF 023
SCH 202676 hydrobromide

(5) Tocris Compounds for GNAZ Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNAZ: view

Transcripts for GNAZ Gene

mRNA/cDNA for GNAZ Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNAZ Gene

Guanine nucleotide binding protein (G protein), alpha z polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAZ Gene

No ASD Table

Relevant External Links for GNAZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNAZ Gene

mRNA expression in normal human tissues for GNAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5), Frontal cortex (13.1), Brain (9.6), Platelet (8.8), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GNAZ Gene

SOURCE GeneReport for Unigene cluster for GNAZ Gene Hs.584760

genes like me logo Genes that share expression patterns with GNAZ: view

Protein tissue co-expression partners for GNAZ Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAZ Gene

Orthologs for GNAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAZ Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GNAZ 35
  • 93.33 (n)
  • 99.15 (a)
  • 99 (a)
(Mus musculus)
Mammalia Gnaz 35
  • 92.21 (n)
  • 98.31 (a)
Gnaz 16
Gnaz 36
  • 98 (a)
(Pan troglodytes)
Mammalia GNAZ 35
  • 99.62 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Gnaz 35
  • 91.64 (n)
  • 98.31 (a)
(Bos Taurus)
Mammalia GNAZ 36
  • 94 (a)
(Monodelphis domestica)
Mammalia GNAZ 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GNAZ 36
  • 95 (a)
(Gallus gallus)
Aves GNAZ 35
  • 82.25 (n)
  • 97.18 (a)
  • 97 (a)
(Anolis carolinensis)
Reptilia GNAZ 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gnaz 35
  • 81.69 (n)
  • 96.34 (a)
(Danio rerio)
Actinopterygii gnaz 35
  • 80.25 (n)
  • 93.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea gpa-11 37
  • 38 (a)
gpa-14 37
  • 32 (a)
gpa-15 37
  • 41 (a)
gpa-2 37
  • 42 (a)
gpa-3 37
  • 47 (a)
gpa-4 37
  • 50 (a)
gpa-5 37
  • 32 (a)
gpa-6 37
  • 37 (a)
gpa-7 37
  • 52 (a)
gpa-9 37
  • 34 (a)
odr-3 37
  • 44 (a)
Species with no ortholog for GNAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAZ Gene

Gene Tree for GNAZ (if available)
Gene Tree for GNAZ (if available)

Paralogs for GNAZ Gene

Paralogs for GNAZ Gene

(19) SIMAP similar genes for GNAZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNAZ: view

Variants for GNAZ Gene

Structural Variations from Database of Genomic Variants (DGV) for GNAZ Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
esv34158 CNV Loss 18971310
dgv4902n71 CNV Loss 21882294
esv24055 CNV Loss 19812545
dgv19e24 CNV Loss 17666407
nsv914577 CNV Loss 21882294
nsv3573 CNV Loss 18451855
nsv525485 CNV Loss 19592680
esv33363 CNV Gain+Loss 17666407

Variation tolerance for GNAZ Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for GNAZ Gene

Disorders for GNAZ Gene

MalaCards: The human disease database

(4) MalaCards diseases for GNAZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • bordetella infection
autosomal dominant congenital stationary night blindness
  • adcsnb
congenital stationary night blindness
  • congenital essential nyctalopia
  • achm
- elite association - COSMIC cancer census association via MalaCards
Search GNAZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNAZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GNAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNAZ Gene

Publications for GNAZ Gene

  1. Characterization of the human gene for Gx alpha, a pertussis toxin- insensitive regulatory GTP-binding protein. (PMID: 2115889) Matsuoka M. … Kaziro Y. (J. Biol. Chem. 1990) 2 3 4 67
  2. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (PMID: 1908722) Gagnon A.W. … Brass L.F. (Blood 1991) 3 23
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GNAZ Gene

Sources for GNAZ Gene