GNAT3 Gene
protein-coding GIFtS: 50
GCID: GC07M080087
|
|
guanine nucleotide binding protein, alpha transducing 3
| |
Aliases
for GNAT3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Guanine Nucleotide Binding Protein, Alpha Transducing 31 2 | | GDCA1 2 | | Gustducin Alpha-3 Chain2 3 | | Gustducin1 | | Guanine Nucleotide-Binding Protein G(T) Subunit Alpha-32 |
Export aliases for GNAT3 gene to outside databasesPrevious GC identifers: GC07M079700 GC07M079732 GC07M079925 GC07M074691 |
Summaries
for GNAT3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweettaste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate)taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with acGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open acyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release ofneurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue,whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweetcompounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for betaand gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 canfunctionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 sensessweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions alsoas lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response todietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropicpolypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromesand diet-related disorders including diabetes and obesity
 summary
for GNAT3: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.
Gene Wiki entry for GNAT3
|
Genomic Views
for GNAT3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNAT3 gene promoter:
RP58 p53 HOXA3 AML1a S8 POU2F1 POU2F1a FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNAT3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAT3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.11 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21.11GNAT3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M080087: view genomic region
(about GC identifiers)
Start:
|
80,087,987 bp from pter |
End:
|
80,141,336 bp from pter |
Size:
|
53,350 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 79,419,422-79,472,664 |
|
Proteins
for GNAT3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein G(t) subunit alpha-3 Size: 354 amino acids; 40357 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for Gustducinheterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding site. Gustducinheterotrimer may also be composed of GNAT3, GNB3 and GNG13
Subcellular location: Cytoplasm. Note=Dual ditribution pattern; plasmalemmal pattern with apical region localizationand cytosolic pattern with localization throughout the cytoplasm
Sequence caution: Sequence=EAL24192.1; Type=Erroneous gene model prediction; Sequence=EAL24193.1; Type=Erroneous genemodel prediction;
Secondary accessions: A4D1B2 A4D1B3 B9EJG5Explore the universe of human proteins at neXtProt for GNAT3: NX_A8MTJ3
Post-translational modifications:
Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MTJ3
GNAT3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001095856.1
ENSEMBL proteins: ENSP00000381339 Reactome Protein details: A8MTJ3
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
GNAT3 for ontologies About GeneDecksing
GNAT3 Antibody Products:
Assay Products for GNAT3: |
Protein
Domains /
Families
for GNAT3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNAT3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MTJ3ProtoNet protein and cluster: A8MTJ3 UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily |
Function
for GNAT3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweettaste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate)taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with acGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open acyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release ofneurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue,whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweetcompounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for betaand gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 canfunctionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 sensessweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions alsoas lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response todietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropicpolypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromesand diet-related disorders including diabetes and obesity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GNAT3 (NM_001102386) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNAT3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAT3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAT3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001664 | G-protein coupled receptor binding |
IBA | -- | | GO:0003924 | GTPase activity |
IBA | -- | | GO:0004871 | signal transducer activity |
IBA | -- | | GO:0005525 | GTP binding |
IEA | -- | | GO:0031683 | G-protein beta/gamma-subunit complex binding |
IBA | -- |
GNAT3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Gnat3tm1Rfm for GNAT3
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gnat3):
GNAT3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GNAT3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Opioid Signalling | | | 2 | Signaling by GPCR | | | 3 | Carbohydrate digestion and absorption | | | 4 | Taste transduction | | | 5 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GNAT3
5/6 
Reactome Pathways for GNAT3 (see all 6)
3 
Kegg Pathways (Kegg details for GNAT3):
GNAT3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAT3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for GNAT3 (A8MTJ33 ENSP000003813394) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste |
IBA | -- | | GO:0006184 | GTP catabolic process |
IBA | -- | | GO:0007186 | G-protein coupled receptor signaling pathway |
-- | -- | | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
IBA | -- | | GO:0035094 | response to nicotine |
IEA | -- |
GNAT3 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNAT3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for GNAT3 available from Tocris Bioscience About this table
2 HMDB Compounds for GNAT3 About this table
Search CenterWatch for drugs/clinical trials and news about GNAT3
|
Transcripts
for GNAT3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GNAT3 gene: NM_001102386.1 Unigene Cluster for GNAT3: Guanine nucleotide binding protein, alpha transducing 3 Hs.335049 [show with all ESTs]Unigene Representative Sequence: BC1470161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000398291(uc011kgu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GNAT3 (NM_001102386) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNAT3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAT3 |
Additional cDNA sequence: BC147016.1 BC147017.1 1 DOTS entry: DT.121069392 1 AceView cDNA sequence: AI300449
GeneLoc Exon Structure
|
Expression
for GNAT3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GNAT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GNAT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNAT3
SOURCE GeneReport for Unigene cluster: Hs.335049
UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3Tissue specificity: Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate andfoliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also inspermatozoa
SABiosciences Custom PCR Arrays for GNAT3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAT3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAT3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAT3 |
Orthologs
for GNAT3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GNAT3 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for GNAT3 (if available)
TreeFam Gene Tree for GNAT3 (if available) |
Paralogs
for GNAT3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GNAT3 gene
- GNAQ2 GNA142 GNA112 GNAI32 GNAT22 GNA132 GNAT12 GNAI22
- GNA152 GNA122 GNAZ2 GNAO12 GNAI12
18 SIMAP similar genes for GNAT3 using alignment to 1 protein entry: GNAT3_HUMAN:GNAT2 GNAT1 GNAI2 GNAI3 GNAI1 DKFZp686O0962
GNAZ GNAO1 GNA11 GNA14 GNAQ GNA12
GNA13 GNAL GNA15 GNAS GSA WUGSC
GNAT3 for paralogs About GeneDecksing
|
Genomic Variants
for GNAT3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GNAT3 (80087987 - 80141336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GNAT3
1 Indel: 41379 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAT3 |
|
Disorders
/ Diseases
for GNAT3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNAT3 for disorders About GeneDecksing
OMIM gene information: 139395
OMIM disorders: --
7  diseases for GNAT3: About MalaCardsdental caries was-related disorders fainting pertussis
pharyngitis obesity neuronitis
Human Genome Epidemiology (HuGE) Navigator: GNAT3 (2 documents)
Export disorders for GNAT3 gene to outside databases
|
Publications
for GNAT3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GNAT3 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with GNAT3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. (PubMed id 17724330)1, 2, 9 Jang H.-J.... Egan J.M. (2007)
- Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. (PubMed id 16728727)1, 2, 9 Rozengurt N.... Rozengurt E. (2006)
- T1R3 and gustducin in gut sense sugars to regulate expression of Na+- glucose cotransporter 1. (PubMed id 17724332)1, 2 Margolskee R.F.... Shirazi-Beechey S.P. (2007)
- Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa. (PubMed id 17021831)1, 2 Fehr J....Boekhoff I. (2007)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (2002)
- Human taste cells express the G protein alpha-gustducin and neuron- specific enolase. (PubMed id 8015379)1, 2 Takami S....Getchell M.L. (1994)
- Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PubMed id 10570481)1, 9 Huang L.... Margolskee R.F. (1999)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for GNAT3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNAT3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNAT3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNAT3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GNAT3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GNAT3 gene:
Search GeneIP for patents involving GNAT3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNAT3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GNAT3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAT3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAT3 | | | OriGene Protein Over-expression Lysate for GNAT3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GNAT3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAT3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GNAT3 | | OriGene Custom Protein Services for GNAT3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNAT3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAT3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAT3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAT3 |
| |
 |  |  |  | |
| | | | Tocris compounds for GNAT3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAT3 |
|  |  |  | | | | ThermoFisher Antibody for GNAT3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAT3 |
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