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GNAT3 Gene

protein-coding   GIFtS: 51
GCID: GC07M080087

Guanine Nucleotide Binding Protein, Alpha Transducing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein, Alpha Transducing 31 2
Gustducin Alpha-3 Chain2 3
GDCA2
Guanine Nucleotide-Binding Protein G(T) Subunit Alpha-32

External Ids:    HGNC: 228001   Entrez Gene: 3465622   Ensembl: ENSG000002144157   OMIM: 1393955   UniProtKB: A8MTJ33   

Export aliases for GNAT3 gene to outside databases

Previous GC identifers: GC07M079700 GC07M079732 GC07M079925 GC07M074691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNAT3 Gene:
GNAT3 (guanine nucleotide binding protein, alpha transducing 3) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and
sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine
monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface
receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and
cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately
leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and
cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces
response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via
activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and
increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular
signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the
T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the
expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of
Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut
capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including
diabetes and obesity

summary for GNAT3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAT3 gene promoter:
         RP58   p53   HOXA3   AML1a   S8   POU2F1   POU2F1a   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GNAT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.11

GNAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAT3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M080087:  view genomic region     (about GC identifiers)

Start:
80,087,987 bp from pter      End:
80,141,336 bp from pter
Size:
53,350 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 79,419,422-79,472,664     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(t) subunit alpha-3  
Size: 354 amino acids; 40357 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for
Gustducin heterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding
site. Gustducin heterotrimer may also be composed of GNAT3, GNB3 and GNG13
Sequence caution: Sequence=EAL24192.1; Type=Erroneous gene model prediction; Sequence=EAL24193.1; Type=Erroneous
gene model prediction;
Secondary accessions: A4D1B2 A4D1B3 B9EJG5

Explore the universe of human proteins at neXtProt for GNAT3: NX_A8MTJ3

Explore proteomics data for GNAT3 at MOPED

Post-translational modifications: 

  • Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane (By similarity)1
  • Ubiquitination2 at Lys46
  • Modification sites at PhosphoSitePlus

  • See GNAT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001095856.1  
    ENSEMBL proteins: 
     ENSP00000381339  
    Reactome Protein details: A8MTJ3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry A8MTJ3

    ProtoNet protein and cluster: A8MTJ3

    UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Find genes that share domains with GNAT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAT3_HUMAN, A8MTJ3
    Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and
    sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine
    monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface
    receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and
    cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately
    leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and
    cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces
    response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via
    activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and
    increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular
    signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the
    T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the
    expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of
    Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut
    capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including
    diabetes and obesity

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    Find genes that share ontologies with GNAT3           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnat3):
     nervous system  taste/olfaction 

    Find genes that share phenotypes with GNAT3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gnat3tm1Rfm for GNAT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNAT3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNAT3_HUMAN, A8MTJ3: Cytoplasm. Note=Dual ditribution pattern; plasmalemmal pattern with apical region
    localization and cytosolic pattern with localization throughout the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    mitochondrion2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0001750photoreceptor outer segment IBA--
    GO:0001917photoreceptor inner segment IBA--
    GO:0005737cytoplasm ----
    GO:0005834heterotrimeric G-protein complex IBA--

    Find genes that share ontologies with GNAT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNAT3 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    G-protein activation0.74
    ADP signalling through P2Y purinoceptor 120.74
    G alpha (z) signalling events0.47
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3GABA receptor activation
    GABA B receptor activation0.73
    GABA receptor activation0.73
    Activation of GABAB receptors0.73
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65


    Find genes that share SuperPaths with GNAT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GNAT3
        Bitter Taste Signaling

    Selected Reactome Pathways for GNAT3 (see all 8)
        G alpha (z) signalling events
    G-protein activation
    Adenylate cyclase inhibitory pathway
    PLC beta mediated events
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for GNAT3):
        Taste transduction
    Phototransduction
    Carbohydrate digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNAT3
    Interactions:

        GeneGlobe Interaction Network for GNAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAT3 (A8MTJ33 ENSP000003813394) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GCGENSP000003876624STRING: ENSP00000387662
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNAO1ENSP000002624934STRING: ENSP00000262493
    GNAT1ENSP000002324614STRING: ENSP00000232461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IBA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS--

    Find genes that share ontologies with GNAT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNAT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    2 HMDB Compounds for GNAT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNAT3 gene: 
    NM_001102386.1  

    Unigene Cluster for GNAT3:

    Guanine nucleotide binding protein, alpha transducing 3
    Hs.335049  [show with all ESTs]
    Unigene Representative Sequence: BC147016
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000398291(uc011kgu.2)
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    Additional mRNA sequence: 

    BC147016.1 BC147017.1 

    1 DOTS entry:

    DT.121069392 

    1 AceView cDNA sequence:

    AI300449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GNAT3 Expression
    About this image

    GNAT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335049

    UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
    Tissue specificity: Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate
    and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected
    also in spermatozoa

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNAT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnat31 , 5 guanine nucleotide binding protein, alpha transducing more1, 5 88.04(n)1
    95.48(a)1
      5 (8.14 cM)5
    2428511  NM_001081143.11  NP_001074612.11 
     179625705 
    chicken
    (Gallus gallus)
    Aves GNAT31 guanine nucleotide binding protein, alpha transducing more 78.63(n)
    81.92(a)
      427851  NM_001267811.1  NP_001254740.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAT36
    guanine nucleotide binding protein, alpha transduc...
    85(a)
    1 ↔ 1
    5(93278219-93296066)
    zebrafish
    (Danio rerio)
    Actinopterygii gnao1b6
    guanine nucleotide binding protein (G protein), al...
    60(a)
    many ↔ many
    7(30469829-30481054) ENSDARG00000036058
    fruit fly
    (Drosophila melanogaster)
    Insecta G-oalpha47A6
    G protein oalpha 47A
    58(a)
    1 → many
    2R(6325490-6353206)
    worm
    (Caenorhabditis elegans)
    Secernentea goa-16
    Protein GOA-1 (goa-1) mRNA, complete cds
    56(a)
    1 → many
    I(7522116-7526703) WBGene00001648
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GP ALPHA 11 GP ALPHA 1 51.34(n)
    39.37(a)
      817170  NM_128187.3  NP_180198.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g03332001 Os05g0333200 52.96(n)
    41.42(a)
      4338448  NM_001061761.1  NP_001055226.1 


    ENSEMBL Gene Tree for GNAT3 (if available)
    TreeFam Gene Tree for GNAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for GNAT3 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT12  GNA122  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAT3 using alignment to 1 protein entry:     GNAT3_HUMAN:
    GNAT2    GNAT1    GNAI2    GNAI3    GNAI1    DKFZp686O0962
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    Find genes that share paralogs with GNAT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNAT3 (see all 1112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557781331,2
    C,F--80087652(+) TCTTCA/GTTATT 1 -- ds50012Minor allele frequency- G:0.04NA 122
    rs1494575471,2
    --80087785(+) CCATTC/TCCCAT 1 -- ds50010--------
    rs20746721,2
    C,F--80087859(+) ACTTTT/GTGCTT 1 -- ds50014Minor allele frequency- G:0.08EA WA NA 1836
    rs171539601,2
    C,F,H--80087871(+) ACAATC/G/TCTAGT 1 -- ds50018NA NS EA WA 678
    rs20746731,2
    C,F,A,H--80087981(+) AAAATG/AGTTGA 1 -- ds500123Minor allele frequency- A:0.45EA NS NA WA CSA EU 4435
    rs1868772321,2
    --80087989(+) TGATTA/GGAAAA 2 Q * stop-lost0--------
    rs1920648111,2
    C--80088014(+) AGATTA/CTCTTT 2 E D mis10--------
    rs1441895181,2
    C,F--80088038(+) GTAACT/CGCGTC 2 /A syn11Minor allele frequency- C:0.01EU 593
    rs20746741,2
    C,F,O,A,H--80088041(+) ACTGCA/GTCAAA 2 D syn129Minor allele frequency- G:0.46EA NS NA WA CSA EU 5062
    rs1839060331,2
    --80088306(+) GCAACA/GGTCAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNAT3 (80087987 - 80141336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNAT3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734735CNV Deletion23290073
    esv2734733CNV Deletion23290073
    esv2734736CNV Deletion23290073
    esv3363CNV Deletion18987735
    esv2734734CNV Deletion23290073
    nsv888512CNV Loss21882294
    nsv888523CNV Loss21882294
    nsv831043CNV Loss17160897
    nsv365325CNV Loss16902084
    nsv464604CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAT3
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139395    OMIM disorders: --


    Find genes that share disorders with GNAT3           About GenesLikeMe

    Genetic Association Database (GAD): GNAT3
    Human Genome Epidemiology (HuGE) Navigator: GNAT3 (2 documents)

    Export disorders for GNAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNAT3 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with GNAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. (PubMed id 17724330)1, 2, 9 Jang H.-J.... Egan J.M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    2. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. (PubMed id 16728727)1, 2, 9 Rozengurt N.... Rozengurt E. (Am. J. Physiol. 2006)
    3. Taste genes associated with dental caries. (PubMed id 20858777)1, 4 Wendell S....Marazita M.L. (J. Dent. Res. 2010)
    4. T1R3 and gustducin in gut sense sugars to regulate expression of Na+- glucose cotransporter 1. (PubMed id 17724332)1, 2 Margolskee R.F.... Shirazi-Beechey S.P. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa. (PubMed id 17021831)1, 2 Fehr J.... Boekhoff I. (J. Comp. Physiol. A 2007)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Human taste cells express the G protein alpha-gustducin and neuron- specific enolase. (PubMed id 8015379)1, 2 Takami S....Getchell M.L. (Brain Res. Mol. Brain Res. 1994)
    10. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PubMed id 10570481)1, 9 Huang L.... Margolskee R.F. (Nat. Neurosci. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 346562 HGNC: 22800 AceView: GNAT3 Ensembl:ENSG00000214415 euGenes: HUgn346562
    ECgene: GNAT3 Kegg: 346562 H-InvDB: GNAT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNAT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNAT3 gene:
    Search GeneIP for patents involving GNAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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