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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAT3 Gene

protein-coding   GIFtS: 51
GCID: GC07M080087

Guanine Nucleotide Binding Protein, Alpha Transducing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein, Alpha Transducing 31 2
Gustducin Alpha-3 Chain2 3
GDCA2
Guanine Nucleotide-Binding Protein G(T) Subunit Alpha-32

External Ids:    HGNC: 228001   Entrez Gene: 3465622   Ensembl: ENSG000002144157   OMIM: 1393955   UniProtKB: A8MTJ33   

Export aliases for GNAT3 gene to outside databases

Previous GC identifers: GC07M079700 GC07M079732 GC07M079925 GC07M074691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GNAT3 Gene: 
GNAT3 (guanine nucleotide binding protein, alpha transducing 3) is a protein-coding gene. Diseases associated with GNAT3 include dental caries, and fainting, and among its related super-pathways are Signaling by GPCR and GABA receptor activation. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and
sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine
monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface
receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and
cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately
leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and
cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces
response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via
activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and
increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular
signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the
T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the
expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of
Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut
capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including
diabetes and obesity

summary for GNAT3 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAT3 gene promoter:
         RP58   p53   HOXA3   AML1a   S8   POU2F1   POU2F1a   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GNAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.11

GNAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAT3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M080087:  view genomic region     (about GC identifiers)

Start:
80,087,987 bp from pter      End:
80,141,336 bp from pter
Size:
53,350 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 79,419,422-79,472,664     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(t) subunit alpha-3  
Size: 354 amino acids; 40357 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for
Gustducin heterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding
site. Gustducin heterotrimer may also be composed of GNAT3, GNB3 and GNG13
Subcellular location: Cytoplasm. Note=Dual ditribution pattern; plasmalemmal pattern with apical region
localization and cytosolic pattern with localization throughout the cytoplasm
Sequence caution: Sequence=EAL24192.1; Type=Erroneous gene model prediction; Sequence=EAL24193.1; Type=Erroneous
gene model prediction;
Secondary accessions: A4D1B2 A4D1B3 B9EJG5

Explore the universe of human proteins at neXtProt for GNAT3: NX_A8MTJ3

Explore proteomics data for GNAT3 at MOPED 

Post-translational modifications:

  • UniProtKB: Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MTJ3

  • GNAT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNAT3 Protein Expression
    REFSEQ proteins: NP_001095856.1  
    ENSEMBL proteins: 
     ENSP00000381339  
    Reactome Protein details: A8MTJ3
    Human Recombinant Protein Products for GNAT3: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IBA--
    GO:0001917photoreceptor inner segment IBA--
    GO:0005737cytoplasm IEA--
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--

    GNAT3 for ontologies           About GeneDecksing



    GNAT3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry A8MTJ3

    ProtoNet protein and cluster: A8MTJ3

    UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    GNAT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAT3_HUMAN, A8MTJ3
    Function: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and
    sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine
    monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface
    receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and
    cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately
    leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and
    cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces
    response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via
    activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and
    increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular
    signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the
    T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the
    expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of
    Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut
    capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including
    diabetes and obesity

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    GNAT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnat3):
     nervous system  taste/olfaction 

    GNAT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gnat3tm1Rfm for GNAT3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNAT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNAT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAT3 

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNAT3 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Activation of GABAB receptors
    Activation of GABAB receptors0.72
    GABA B receptor activation0.72
    GABA receptor activation0.72
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    5Prostacyclin signalling through prostacyclin receptor
    ADP signalling through P2Y purinoceptor 120.72
    G-protein activation0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GNAT3
        Bitter Taste Signaling

    5/20        Reactome Pathways for GNAT3 (see all 20)
        Transmission across Chemical Synapses
    Neuronal System
    Opioid Signalling
    G-protein activation
    Adenylate cyclase inhibitory pathway


    3         Kegg Pathways  (Kegg details for GNAT3):
        Taste transduction
    Phototransduction
    Carbohydrate digestion and absorption


    GNAT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for GNAT3 (A8MTJ33 ENSP000003813394) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG13Q9P2W33, ENSP000002481504I2D: score=1 STRING: ENSP00000248150
    GCGENSP000003876624STRING: ENSP00000387662
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNAO1ENSP000002624934STRING: ENSP00000262493
    GNAT1ENSP000002324614STRING: ENSP00000232461
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IBA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS--

    GNAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNAT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    2 HMDB Compounds for GNAT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about GNAT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNAT3 gene: 
    NM_001102386.1  

    Unigene Cluster for GNAT3:

    Guanine nucleotide binding protein, alpha transducing 3
    Hs.335049  [show with all ESTs]
    Unigene Representative Sequence: BC147016
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000398291(uc011kgu.2)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAT3

    Additional mRNA sequence: 

    BC147016.1 BC147017.1 

    1 DOTS entry:

    DT.121069392 

    1 AceView cDNA sequence:

    AI300449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GNAT3 Expression
    About this image


    See GNAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAT3

    SOURCE GeneReport for Unigene cluster: Hs.335049

    UniProtKB/Swiss-Prot: GNAT3_HUMAN, A8MTJ3
    Tissue specificity: Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate
    and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected
    also in spermatozoa

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GNAT3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnat31 , 5 guanine nucleotide binding protein, alpha transducing more1, 5 88.04(n)1
    95.48(a)1
      5 (8.14 cM)5
    2428511  NM_001081143.11  NP_001074612.11 
     179625705 
    chicken
    (Gallus gallus)
    Aves GNAT31 guanine nucleotide binding protein, alpha transducing more 78.63(n)
    81.92(a)
      427851  XM_425425.3  XP_425425.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAT36
    Uncharacterized protein
    85(a)
    1 ↔ 1
    5(93278219-93296066)
    zebrafish
    (Danio rerio)
    Actinopterygii gnat26
    guanine nucleotide binding protein (G protein), al...
    74(a)
    1 → many
    8(26078533-26100227)


    ENSEMBL Gene Tree for GNAT3 (if available)
    TreeFam Gene Tree for GNAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAT3 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT12  GNA122  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAT3 using alignment to 1 protein entry:     GNAT3_HUMAN:
    GNAT2    GNAT1    GNAI2    GNAI3    GNAI1    DKFZp686O0962
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    GNAT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1112 SNPs in GNAT3 are shown (see all 1112)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557781331,2
    C,F--80087652(+) TCTTCA/GTTATT 1 -- ds50012Minor allele frequency- G:0.04NA 122
    rs1494575471,2
    --80087785(+) CCATTC/TCCCAT 1 -- ds50010--------
    rs20746721,2
    C,F--80087859(+) ACTTTT/GTGCTT 1 -- ds50014Minor allele frequency- G:0.08EA WA NA 1836
    rs171539601,2
    C,F,H--80087871(+) ACAATC/G/TCTAGT 1 -- ds50018NA NS EA WA 678
    rs20746731,2
    C,F,A,H--80087981(+) AAAATG/AGTTGA 1 -- ds500123Minor allele frequency- A:0.45EA NS NA WA CSA EU 4435
    rs1868772321,2
    --80087989(+) TGATTA/GGAAAA 2 Q * stop-lost0--------
    rs1920648111,2
    C--80088014(+) AGATTA/CTCTTT 2 E D mis10--------
    rs1441895181,2
    C,F--80088038(+) GTAACT/CGCGTC 2 /A syn11Minor allele frequency- C:0.01EU 593
    rs20746741,2
    C,F,O,A,H--80088041(+) ACTGCA/GTCAAA 2 D syn129Minor allele frequency- G:0.46EA NS NA WA CSA EU 5062
    rs1839060331,2
    --80088306(+) GCAACA/GGTCAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNAT3 (80087987 - 80141336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for GNAT3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734735CNV Deletion23290073
    esv2734733CNV Deletion23290073
    esv2734736CNV Deletion23290073
    esv3363CNV Deletion18987735
    esv2734734CNV Deletion23290073
    nsv888512CNV Loss21882294
    nsv888523CNV Loss21882294
    nsv831043CNV Loss17160897
    nsv365325CNV Loss16902084
    nsv464604CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139395    OMIM disorders: --

    6 diseases for GNAT3:    About MalaCards
    dental caries    fainting    was-related disorders    pertussis
    obesity    neuronitis


    GNAT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNAT3
    Human Genome Epidemiology (HuGE) Navigator: GNAT3 (2 documents)

    Export disorders for GNAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAT3 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with GNAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. (PubMed id 17724330)1, 2, 9 Jang H.-J.... Egan J.M. (2007)
    2. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. (PubMed id 16728727)1, 2, 9 Rozengurt N.... Rozengurt E. (2006)
    3. Taste genes associated with dental caries. (PubMed id 20858777)1, 4 Wendell S....Marazita M.L. (2010)
    4. T1R3 and gustducin in gut sense sugars to regulate expression of Na+- glucose cotransporter 1. (PubMed id 17724332)1, 2 Margolskee R.F.... Shirazi-Beechey S.P. (2007)
    5. Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa. (PubMed id 17021831)1, 2 Fehr J....Boekhoff I. (2007)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (2002)
    9. Human taste cells express the G protein alpha-gustducin and neuron- specific enolase. (PubMed id 8015379)1, 2 Takami S....Getchell M.L. (1994)
    10. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. (PubMed id 10570481)1, 9 Huang L.... Margolskee R.F. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 346562 HGNC: 22800 AceView: GNAT3 Ensembl:ENSG00000214415 euGenes: HUgn346562
    ECgene: GNAT3 Kegg: 346562 H-InvDB: GNAT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNAT3 gene:
    Search GeneIP for patents involving GNAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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