Aliases for GNAT2 Gene
External Ids for GNAT2 Gene
Previous GeneCards Identifiers for GNAT2 Gene
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNAT2 Gene
GNAT2 (G Protein Subunit Alpha Transducin 2) is a Protein Coding gene. Diseases associated with GNAT2 include achromatopsia-4 and cone-rod dystrophy 6. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNAT2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.