Aliases for GNAT1 Gene
External Ids for GNAT1 Gene
Previous GeneCards Identifiers for GNAT1 Gene
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
GeneCards Summary for GNAT1 Gene
GNAT1 (Guanine Nucleotide Binding Protein (G Protein), Alpha Transducing Activity Polypeptide 1) is a Protein Coding gene. Diseases associated with GNAT1 include night blindness, congenital stationary, autosomal dominant 3 and night blindness, congenital stationary, type 1g. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNAT1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.