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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNAO1 Gene

protein-coding GIFtS: 64
GCID: GC16P056277

guanine nucleotide binding protein (G protein), alpha activating...

Explore 16 diseases affiliated with
GNAO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O¹ ²
G-ALPHA-O¹
GNAO²
Guanine Nucleotide-Binding Protein G(O) Subunit Alpha²

External Ids:	HGNC: 4389¹	Entrez Gene: 2775²	Ensembl: ENSG00000087258⁷	OMIM: 139311⁵	UniProtKB: P09471³

Export aliases for GNAO1 gene to outside databases

Previous GC identifers: GC16P046608 GC16P055961 GC16P056001 GC16P056000 GC16P054783 GC16P042096

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

summary for GNAO1:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind

directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in

cAMP levels respectively.

Gene Wiki entry for GNAO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNAO1 gene promoter:
Brachyury SREBP-1c HNF-3beta E47 SREBP-1b SREBP-1a HOXA5 Hand1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNAO1 promoter sequence

Search SABiosciences Chromatin IP Primers for GNAO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13

GNAO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAO1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P056277: view genomic region (about GC identifiers)

Start:	56,225,251 bp from pter	End:	56,391,356 bp from pter
Size:	166,106 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(o) subunit alpha

Size: 354 amino acids; 40051 Da

Subunit: Interacts with RGS14 (By similarity). G proteins are composed of 3 units; alpha, beta and gamma. The alpha

chain contains the guanine nucleotide binding site

Secondary accessions: P29777 Q8TD72 Q9UMV4

Alternative splicing: 2 isoforms: P09471-1 P09471-2, P29777-1

Explore the universe of human proteins at neXtProt for GNAO1: NX_P09471

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09471

GNAO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_066268.1 NP_620073.2

ENSEMBL proteins:

ENSP00000262493 ENSP00000262494 ENSP00000454728 ENSP00000457238 ENSP00000455774

ENSP00000454971

Reactome Protein details: P09471
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005834	heterotrimeric G-protein complex	IBA	--
GO:0005886	plasma membrane	TAS	--
GO:0019717	synaptosome	--	--

GNAO1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNAO1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001019 Gprotein_alpha_su

IPR011025 GproteinA_insert

IPR001408 Gprotein_alpha_I

Graphical View of Domain Structure for InterPro Entry P09471

ProtoNet protein and cluster: P09471

2 Blocks protein families:

IPB001019 Alpha G-protein (transducin) signature

IPB001408 G-protein alpha subunit group I signature

UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471

Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

Genatlas biochemistry entry for GNAO1:

guanine nucleotide binding protein (G protein),alpha activating,polypeptide O

miRNA Products:		OriGene 3'-UTR Clone (see all 2): GNAO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAO1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAO1 (see all 48):
		hsa-miR-193a-3p hsa-miR-19b-2* hsa-miR-134 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-550a* hsa-miR-877*

		SwitchGear 3'UTR luciferase reporter plasmid: GNAO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for GNAO1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAO1

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IBA	--
GO:0004871	signal transducer activity	IBA	--
GO:0005515	protein binding	--	--
GO:0005525	GTP binding	IEA	--
GO:0031683	G-protein beta/gamma-subunit complex binding	IBA	--

GNAO1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for GNAO1: Gnao1^tm1Lbi Gnao1^tm2Lbi Gnao1^tm4.1Lbi Gnao1^tm3Lbi
     10 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gnao1):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	growth/size	homeostasis/metabolism
integument	mortality/aging	nervous system	reproductive system	vision/eye

GNAO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/54 super-pathways (see all 54) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_Dopamine D2 receptor transactivation of EGFR

Development_Dopamine D2 receptor transactivation of EGFR	1.00	Development Alpha-2 adrenergic receptor activation of ERK	0.66
Development Dopamine D2 receptor transactivation of EGFR	1.00	Chemotaxis_CXCR4 signaling pathway	0.48
Development_Alpha-2 adrenergic receptor activation of ERK	0.66	Chemotaxis CXCR4 signaling pathway	0.48

G Protein Signaling Pathways

G Protein Signaling Pathways	1.00	Signal transduction_PKA signaling	0.23
Signal transduction cAMP signaling	0.44	Signal transduction PKA signaling	0.23
Signal transduction_cAMP signaling	0.44

G-Beta Gamma Signaling

G-Beta Gamma Signaling	1.00	Relaxin Pathway	0.32
GHRH Signaling	0.46	Hedgehog Signaling in Mammals	0.22
CRHR Pathway	0.44

Development_A3 receptor signaling

	Development_A3 receptor signaling	1.00			Development_A1 receptor signaling	0.65
	Development A3 receptor signaling	1.00			Development A1 receptor signaling	0.65

Pathway sources
See GeneCards unified pathways
Show all pathways

5/25 EMD Millipore Pathways for GNAO1 (see all 25)

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Development A1 receptor signaling
	Immune response CCR3 signaling in eosinophils

5/40 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAO1 (see all 40)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	CDK5 Pathway
	ERK5 Signaling

2 Cell Signaling Technology (CST) Pathways for GNAO1

	Ca, cAMP and Lipid Signaling
	Neuroscience

5/27 GeneGo (Thomson Reuters) Pathways for GNAO1 (see all 27)

	Signal transduction cAMP signaling
	Development Endothelin-1/EDNRA signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

5/10 BioSystems Pathways for GNAO1 (see all 10)

	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways
	TSH signaling pathway
	S1P5 pathway
	LPA receptor mediated events

5/6 Reactome Pathways for GNAO1 (see all 6)

	G-protein activation
	G-protein mediated events
	PLC beta mediated events
	Signal Transduction
	Signaling by GPCR

5/6 Kegg Pathways (Kegg details for GNAO1) (see all 6):

	Glutamatergic synapse
	Cholinergic synapse
	Long-term depression
	Melanogenesis
	Chagas disease (American trypanosomiasis)

GNAO1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GNAO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/172 Interacting proteins for GNAO1 (P09471^{2, 3} ENSP00000262493⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 172)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCTN2	Q13561²^,³, ENSP00000408910⁴	MINT-64140 I2D: score=5 STRING: ENSP00000408910
CXCR5	P32302²^,³, ENSP00000292174⁴	MINT-50706 I2D: score=1 STRING: ENSP00000292174
RIC8A	Q9NPQ8³, ENSP00000325941⁴	I2D: score=6 STRING: ENSP00000325941
GPSM2	P81274³, ENSP00000264126⁴	I2D: score=3 STRING: ENSP00000264126
OPRD1	P41143³, ENSP00000234961⁴	I2D: score=3 STRING: ENSP00000234961

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	1899283
GO:0006936	muscle contraction	TAS	9050846
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA	--
GO:0007212	dopamine receptor signaling pathway	IBA	--

GNAO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNAO1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Mastoparan X	G protein activator peptide	[72093-22-2]
NF 023	Selective, competitive P2X antagonist	[104869-31-0]
Mastoparan	Activates Gi and Go	[72093-21-1]
Pertussis Toxin	Catalyzes ADP-ribosylation of Gi, Go and Gt	[70323-44-3]

3 HMDB Compounds for GNAO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNAO1 / GNAO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNAO1 gene (2 alternative transcripts):

NM_020988.2 NM_138736.2

Unigene Cluster for GNAO1:

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

Hs.644524 [show with all ESTs]

Unigene Representative Sequence: NM_138736

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262493(uc002eiu.4) ENST00000570235 ENST00000262494(uc002eit.4)

ENST00000569295 ENST00000563661 ENST00000565363 ENST00000562316 ENST00000563440

ENST00000568375 ENST00000564798 ENST00000564727

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		hsa-miR-193a-3p hsa-miR-19b-2* hsa-miR-134 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-550a* hsa-miR-877*

		SwitchGear 3'UTR luciferase reporter plasmid: GNAO1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAO1

Additional cDNA sequence:

AF493894.1 AF493895.1 AK056008.1 AK295680.1 AL512686.1 BC012202.1 BC030027.2 BX647214.1

CR936770.1 Y18213.1

16 DOTS entries:

DT.216381 DT.102831207 DT.422663 DT.75159089 DT.70104759 DT.101974960 DT.95141709 DT.91806146

DT.100815630 DT.120682463 DT.120682481 DT.120682496 DT.75150315 DT.86840748 DT.95141707 DT.97841585

24/167 AceView cDNA sequences (see all 167):

BQ272003 BE382670 BQ069504 W96534 CK300670 AI675696 AI188097 BP360345

AW298733 AL134364 F03776 BI669552 BE673944 BQ890623 AF493894 BP360315

BI601581 AL565628 BQ184195 AL512686 BF946900 BQ184493 BQ185884 BG055096

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GNAO1 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15a	·	15b	^	16
SP1:					-		-				-		-		-				-		-		-														-		-						-
SP2:					-		-				-		-		-				-		-		-
SP3:											-		-		-				-		-		-
SP4:											-		-						-		-		-
SP5:															-				-		-		-

ECgene alternative splicing isoforms for GNAO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNAO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAATCCTA

About this image

GNAO1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Type5 On Cone Bipolar Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Type6 On Cone Bipolar Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Type7 On Cone Bipolar Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Type8 On Cone Bipolar Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Type9 On Cone Bipolar Cells

Bipolar, Retina

Brain

Eye

Diencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNAO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNAO1

SOURCE GeneReport for Unigene cluster: Hs.644524

SABiosciences Expression via Pathway-Focused PCR Array including GNAO1:

Alzheimer's Disease in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNAO1 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNAO1¹	guanine nucleotide binding protein (G protein), alpha more	88.53(n) 98.22(a)		415698 XM_414065.3 XP_414065.3
lizard (Anolis carolinensis)	Reptilia	GNAO1⁶ --	--	93(a) 79(a)	1 ↔ 1 possible ortholog	GL343675.1(5408-24619) AAWZ02037803(3914-7445)
African clawed frog (Xenopus laevis)	Amphibia	gnao1-A²	guanine nucleotide binding protein (G protein), alpha more	83.33(n)		X87116.1
zebrafish (Danio rerio)	Actinopterygii	zgc73315²	hypothetical protein MGC73315	82.81(n)		393760 BC059637.1
fruit fly (Drosophila melanogaster)	Insecta	G-oalpha47A^{1 , 3}	G-protein coupled receptor protein signaling pathway more³ G protein oalpha 47A¹	82(a) (best of 2)³ 71.09(n)¹ 83.05(a)¹		36104¹ NM_176124.2¹ NP_788304.1¹
worm (Caenorhabditis elegans)	Secernentea	goa-1^{1 , 3}	guanine nucleotide-binding protein³ Protein GOA-1¹	82(a) (best of 14)³ 70.9(n)¹ 82.2(a)¹		I(7530272-7533917)³ 172505¹ NM_059707.4¹ NP_492108.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	XLG1⁶ XLG2⁶ (see all 4)	extra-large GTP-binding protein 2 (see all 4)	9(a) 8(a) (see all 4)	many ↔ many many ↔ many (see all 4)	2(9995478-9999122) 4(16441179-16445005)
rice (Oryza sativa)	Liliopsida	XA7⁶ -- (see all 5)	G-protein alpha subunit, putative, expressed (see all 5)	30(a) 18(a) (see all 5)	many ↔ many many ↔ many (see all 5)	5(15552385-15556024) 10(1125704-1130461)

ENSEMBL Gene Tree for GNAO1 (if available)
TreeFam Gene Tree for GNAO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GNAO1 gene

GNAQ² GNA14² GNA11² GNAI3² GNAT2² GNA13² GNAT3² GNAT1²

GNAI2² GNA15² GNA12² GNAZ² GNAI1²

18 SIMAP similar genes for GNAO1 using alignment to 6 protein entries: GNAO_HUMAN (see all proteins):

DKFZp686O0962 GNAI3 GNAT2 GNAT3 GNAZ GNAI2

GNAI1 GNAT1 GNA11 GNA14 GNAQ GNAL

GNA12 GNA13 GNA15 GNAS GSA WUGSC

GNAO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112686726^1,2	C,	--	42202982(+)	`GGGCAC/TGATGG`	1	--	us2k¹		2		NA	122
rs9935654^1,2	C,H,	--	42203984(+)	`AAAAGC/GCTCCT`	1	--	us2k¹		4		NS EA	418
rs74988091^1,2	F,	--	42204604(+)	`AGAAAC/TAAACA`	1	--	us2k¹		1		EA	120
rs11862128^1,2	C,F,H,	--	42204959(+)	`tccagA/Tcttta`	1	--	nc-transcript-variant		7		NS EA WA NA	532
rs76425135^1,2	F,	--	42205422(+)	`TGTGGC/TTGGGG`	1	--	nc-transcript-variant		1		NA	120
rs75755709^1,2	C,F,	--	42205843(+)	`TAAGCG/ACTTAC`	1	--	int¹		3		WA NA EA	358
rs2617836^1,2	F,	--	42206042(+)	`CCGGCG/AGAGTG`	1	--	nc-transcript-variant		1		WA	118
rs62038118^1,2		--	42206313(+)	`GCCCCC/TGCCCA`	1	--	nc-transcript-variant		0	--	--	--	--
rs113093154^1,2	C,	--	42206346(+)	`CAGCAG/ACAGCA`	1	--	nc-transcript-variant		2		NA	122
rs79942529^1,2	F,	--	42206351(+)	`GCAGCA/TCCTCT`	1	--	nc-transcript-variant		1		EA	120

HapMap Linkage Disequilibrium report for GNAO1 (56225251 - 56391356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GNAO1
3 CNVs: 77349 49723 4957

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GNAO1 for disorders           About GeneDecksing

OMIM gene information: 139311    OMIM disorders: --

16 diseases for GNAO1:    About MalaCards

congenital stationary night blindness night blindness blindness fainting

chagas disease trypanosomiasis toxoplasmosis cholera

pertussis pharyngitis cholesterol retinitis

leukemia neuronitis huntington's disease breast cancer

Human Genome Epidemiology (HuGE) Navigator: GNAO1 (2 documents)

Export disorders for GNAO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GNAO1 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with GNAO1)

Utopia: connect your pdf to the dynamic
world of online information

Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels. (PubMed id 11395521)^{1, 3} Kinoshita M....Kaneko S. (2001)
Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy. (PubMed id 10330115)^{1, 2} Duc-Goiran P....Ferre F. (1999)
Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16. (PubMed id 1899283)^{1, 3} Murtagh J.J....Vaughan M. (1991)
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. (PubMed id 1901650)^{1, 2} Tsukamoto T.... Kaziro Y. (1991)
Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. (PubMed id 3124840)^{1, 2} Lavu S....Kung H.-F. (1988)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Gao potentiates estrogen receptor a activity via the E RK signaling pathway. (PubMed id 22562654)¹ Bratton M.R....Burow M.E. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Type 5 G protein beta subunit (Gbeta5) controls the i nteraction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)¹ Masuho I....Martemyanov K.A. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2775	HGNC: 4389	AceView: GNAO1	Ensembl:ENSG00000087258	euGenes: HUgn2775
ECgene: GNAO1	Kegg: 2775	H-InvDB: GNAO1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GNAO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNAO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GNAO1 gene:
Search GeneIP for patents involving GNAO1

GeneCards and IP:
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