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GNAO1 Gene

protein-coding   GIFtS: 67
GCID: GC16P056231

Guanine Nucleotide Binding Protein (G Protein), Alpha Activating...

  See GNAO1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Activating
Activity Polypeptide O1 2
EIEE172 5
G-ALPHA-o2
GNAO2
Guanine Nucleotide-Binding Protein G(O) Subunit Alpha2

External Ids:    HGNC: 43891   Entrez Gene: 27752   Ensembl: ENSG000000872587   OMIM: 1393115   UniProtKB: P094713   

Export aliases for GNAO1 gene to outside databases

Previous GC identifers: GC16P046608 GC16P056277 GC16P055961 GC16P056001 GC16P056000 GC16P054783 GC16P042096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNAO1 Gene:
GNAO1 (guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O) is a protein-coding gene. Diseases associated with GNAO1 include epileptic encephalopathy, early infantile, 17. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

summary for GNAO1 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAO1 gene promoter:
         Brachyury   SREBP-1c   HNF-3beta   E47   SREBP-1b   SREBP-1a   HOXA5   Hand1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAO1 promoter sequence
   Search Chromatin IP Primers for GNAO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

GNAO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAO1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056231:  view genomic region     (about GC identifiers)

Start:
56,225,251 bp from pter      End:
56,391,356 bp from pter
Size:
166,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(o) subunit alpha  
Size: 354 amino acids; 40051 Da
Subunit: Interacts with RGS14 (By similarity). G proteins are composed of 3 units; alpha, beta and gamma. The
alpha chain contains the guanine nucleotide binding site
Secondary accessions: P29777 Q8TD72 Q9UMV4
Alternative splicing: 2 isoforms:  P09471-1   P09471-2, P29777-1   

Explore the universe of human proteins at neXtProt for GNAO1: NX_P09471

Explore proteomics data for GNAO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46
  • Modification sites at PhosphoSitePlus

  • See GNAO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_066268.1  NP_620073.2  

    ENSEMBL proteins: 
     ENSP00000262493   ENSP00000262494   ENSP00000454728   ENSP00000457238   ENSP00000455774  
     ENSP00000454971  
    Reactome Protein details: P09471

    GNAO1 Human Recombinant Protein Products:

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    Novus Biologicals GNAO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNAO1 

     
    antibodies-online proteins for GNAO1 (11 products) 

     
    antibodies-online peptides for GNAO1

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    antibodies-online antibodies for GNAO1 (45 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P09471

    ProtoNet protein and cluster: P09471

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Find genes that share domains with GNAO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAO_HUMAN, P09471
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

         Genatlas biochemistry entry for GNAO1:
    guanine nucleotide binding protein (G protein),alpha activating,polypeptide O

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    Find genes that share ontologies with GNAO1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Gnao1):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  nervous system  reproductive system  vision/eye 

    Find genes that share phenotypes with GNAO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GNAO1: Gnao1tm1Lbi Gnao1tm2Lbi Gnao1tm3Lbi Gnao1tm4.1Lbi

       genOway: Develop your customized and physiologically relevant rodent model for GNAO1

    miRNA
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    hsa-miR-193a-3p hsa-miR-19b-2* hsa-miR-134 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-550a* hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidGNAO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNAO1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IBA--

    Find genes that share ontologies with GNAO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNAO1 About   (see all 57)  
    See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    5Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Estrogen signaling pathway0.34


    Find genes that share SuperPaths with GNAO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNAO1 (see all 40)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for GNAO1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for GNAO1 (see all 27)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for GNAO1 (see all 11)
        G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone
    TSH signaling pathway
    S1P1 pathway


    3 Reactome Pathways for GNAO1
        G-protein activation
    PLC beta mediated events
    Ca2+ pathway


    Selected Kegg Pathways  (Kegg details for GNAO1) (see all 16):
        Rap1 signaling pathway
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Cholinergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Array including GNAO1: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNAO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAO1 (P094712, 3 ENSP000002624934) via UniProtKB, MINT, STRING, and/or I2D (see all 216)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR5P323022, 3, ENSP000002921744MINT-50706 I2D: score=1 STRING: ENSP00000292174
    DCTN2Q135612, 3, ENSP000004089104MINT-64140 I2D: score=5 STRING: ENSP00000408910
    RIC8AQ9NPQ83, ENSP000003259414I2D: score=6 STRING: ENSP00000325941
    OPRD1P411433, ENSP000002349614I2D: score=3 STRING: ENSP00000234961
    ADORA1P305423, ENSP000003085494I2D: score=2 STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS9050846
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007212dopamine receptor signaling pathway IBA--

    Find genes that share ontologies with GNAO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNAO1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNAO1 gene (2 alternative transcripts): 
    NM_020988.2  NM_138736.2  

    Unigene Cluster for GNAO1:

    Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
    Hs.644524  [show with all ESTs]
    Unigene Representative Sequence: NM_138736
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262493(uc002eiu.4) ENST00000570235 ENST00000262494(uc002eit.4)
    ENST00000569295 ENST00000563661 ENST00000565363 ENST00000562316 ENST00000563440
    ENST00000568375 ENST00000564798 ENST00000564727
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    hsa-miR-193a-3p hsa-miR-19b-2* hsa-miR-134 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-550a* hsa-miR-877*
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GNAO1
      QuantiFast Probe-based Assays in human, mouse, rat GNAO1

    Additional mRNA sequence: 

    AF493894.1 AF493895.1 AK056008.1 AK295680.1 AL512686.1 BC012202.1 BC030027.2 BX647214.1 
    CR936770.1 Y18213.1 

    15 DOTS entries:

    DT.216381  DT.102831207  DT.422663  DT.75159089  DT.70104759  DT.101974960  DT.95141709  DT.91806146 
    DT.100815630  DT.120682481  DT.75150315  DT.86840748  DT.95141707  DT.120682463  DT.97841585 

    Selected AceView cDNA sequences (see all 167):

    BE382670 AI675696 BP360345 W96534 BQ069504 BQ272003 AI188097 CK300670 
    BQ963023 BI669552 AW298733 BX118409 F03776 BE673944 AL134364 BQ890623 
    BP360315 AF493894 AA917031 BQ184195 BF946900 AL565628 BI601581 AF493895 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNAO1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:              -     -           -     -     -           -     -     -                                         -     -                 -         
    SP2:              -     -           -     -     -           -     -     -                                                                           
    SP3:                                -     -     -           -     -     -                                                                           
    SP4:                                -     -                 -     -     -                                                                           
    SP5:                                            -           -     -     -                                                                           


    ECgene alternative splicing isoforms for GNAO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNAO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAATCCTA
    GNAO1 Expression
    About this image


    GNAO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    GNAO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644524
        Pathway & Disease-focused RT2 Profiler PCR Array including GNAO1: 
              Alzheimer's Disease in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GNAO1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnao11 , 5 guanine nucleotide binding protein, alpha O1, 5 93.79(n)1
    98.02(a)1
      8 (45.94 cM)5
    146811  NM_010308.31  NP_034438.11 
     938099665 
    chicken
    (Gallus gallus)
    Aves GNAO11 guanine nucleotide binding protein (G protein), alpha more 88.51(n)
    98.31(a)
      415698  NM_001277550.1  NP_001264479.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAO16
    guanine nucleotide binding protein (G protein), al...
    93(a)
    1 ↔ 1
    GL343675.1(5408-26005)
    African clawed frog
    (Xenopus laevis)
    Amphibia gnao1-A2 guanine nucleotide binding protein (G protein), alpha more 83.33(n)    X87116.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733152 hypothetical protein MGC73315 82.81(n)   393760  BC059637.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-oalpha47A1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    G protein oalpha 47A1
    82(a)
    (best of 2)3
    71.09(n)1
    83.05(a)1
      361041  NM_165772.41  NP_724934.11 
    worm
    (Caenorhabditis elegans)
    Secernentea goa-11 , 3 guanine nucleotide-binding protein3
    goa-11
    82(a)
    (best of 14)3
    70.9(n)1
    82.2(a)1
      I(7530272-7533917)3
    1725051  NM_059707.51  NP_492108.11 


    ENSEMBL Gene Tree for GNAO1 (if available)
    TreeFam Gene Tree for GNAO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNAO1 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNAI22  GNA152  GNAZ2  GNAI12  
    18 SIMAP similar genes for GNAO1 using alignment to 6 protein entries:     GNAO_HUMAN (see all proteins):
    DKFZp686O0962    GNAI3    GNAT2    GNAT3    GNAZ    GNAI2
    GNAI1    GNAT1    GNA11    GNA14    GNAQ    GNAL
    GNA12    GNA13    GNA15    GNAS    GSA    WUGSC

    Find genes that share paralogs with GNAO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNAO1 (see all 2863)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708644
    Epileptic encephalopathy, early infantile, 17 (EIEE17)4--see VAR_0708642 D G mis40--------
    VAR_0708664
    Epileptic encephalopathy, early infantile, 17 (EIEE17)4--see VAR_0708662 G R mis40--------
    VAR_0708674
    Epileptic encephalopathy, early infantile, 17 (EIEE17)4--see VAR_0708672 I N mis40--------
    rs724844401,2
    C--42191039(+) GCCTC-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs570067051,2
    C--56229004(+) TTTTT-/T/TTC 
            
    CAACC
    1 -- int12NA CSA 4
    rs11907651,2
    C,F,H--56230478(+) ACCTGG/TTGAAA 2 -- int122Minor allele frequency- T:0.09MN NS EA NA WA 2654
    rs1812576641,2
    C--56230480(+) CTGGTA/GAAAAT 2 -- int10--------
    rs1477264331,2
    --56230535(+) CATTCA/GAGGTG 2 -- int10--------
    rs1853170411,2
    --56230625(+) TGGCCA/GTGAGG 2 -- int10--------
    rs12100831,2
    C,F,H--56230696(+) TGTGCG/ATCCAT 2 -- int123Minor allele frequency- A:0.16MN NS EA NA WA 2392

    HapMap Linkage Disequilibrium report for GNAO1 (56225251 - 56391356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNAO1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714509CNV Deletion23290073
    esv272874CNV Insertion20981092
    nsv525929CNV Loss19592680
    nsv906714CNV Loss21882294
    dgv2870n71CNV Loss21882294
    nsv521726CNV Loss19592680
    nsv523649CNV Loss19592680
    nsv519346CNV Loss19592680
    nsv906715CNV Loss21882294
    nsv833242CNV Loss17160897

    Human Gene Mutation Database (HGMD): GNAO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAO1
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139311   
    OMIM disorders: 615473  
    1 disease for GNAO1:    
    About MalaCards
    epileptic encephalopathy, early infantile, 17


    Find genes that share disorders with GNAO1           About GenesLikeMe

    Genetic Association Database (GAD): GNAO1
    Human Genome Epidemiology (HuGE) Navigator: GNAO1 (2 documents)

    Export disorders for GNAO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNAO1 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with GNAO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels. (PubMed id 11395521)1, 3 Kinoshita M....Kaneko S. (J. Biol. Chem. 2001)
    4. Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy. (PubMed id 10330115)1, 2 Duc-Goiran P....Ferre F. (Biol. Reprod. 1999)
    5. Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16. (PubMed id 1899283)1, 3 Murtagh J.J....Vaughan M. (Mol. Cell. Biol. 1991)
    6. Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. (PubMed id 1901650)1, 2 Tsukamoto T.... Kaziro Y. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. (PubMed id 3124840)1, 2 Lavu S....Kung H.-F. (Biochem. Biophys. Res. Commun. 1988)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. De Novo mutations in GNAO1, encoding a GI+o subunit of heterotrimeric G proteins, cause epileptic encephalopathy. (PubMed id 23993195)1 Nakamura K....Saitsu H. (Am. J. Hum. Genet. 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2775 HGNC: 4389 AceView: GNAO1 Ensembl:ENSG00000087258 euGenes: HUgn2775
    ECgene: GNAO1 Kegg: 2775 H-InvDB: GNAO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNAO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNAO1 gene:
    Search GeneIP for patents involving GNAO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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