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Aliases for GNAL Gene

Aliases for GNAL Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide, Olfactory Type 2 3
  • Adenylate Cyclase-Stimulating G Alpha Protein, Olfactory Type 3 4
  • DYT25 3 6
  • Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide, Olfactory Type 3
  • Guanine Nucleotide-Binding Protein G(Olf) Subunit Alpha 3

External Ids for GNAL Gene

Summaries for GNAL Gene

Entrez Gene Summary for GNAL Gene

  • This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for GNAL Gene

GNAL (Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide, Olfactory Type) is a Protein Coding gene. Diseases associated with GNAL include dystonia 25 and autosomal dominant focal dystonia, dyt25. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAS.

UniProtKB/Swiss-Prot for GNAL Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters

Tocris Summary for GNAL Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAL Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAL Gene

Genomics for GNAL Gene

Genomic Location for GNAL Gene

Start:
11,688,956 bp from pter
End:
11,885,685 bp from pter
Size:
196,730 bases
Orientation:
Plus strand

Genomic View for GNAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAL Gene

Regulatory Elements for GNAL Gene

Proteins for GNAL Gene

  • Protein details for GNAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38405-GNAL_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(olf) subunit alpha
    Protein Accession:
    P38405
    Secondary Accessions:
    • B7ZA26
    • Q86XU3

    Protein attributes for GNAL Gene

    Size:
    381 amino acids
    Molecular mass:
    44308 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site

    Alternative splice isoforms for GNAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNAL Gene

Proteomics data for GNAL Gene at MOPED

Post-translational modifications for GNAL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55, Lys60, and Lys203

No data available for DME Specific Peptides for GNAL Gene

Domains for GNAL Gene

Graphical View of Domain Structure for InterPro Entry

P38405

UniProtKB/Swiss-Prot:

GNAL_HUMAN
Family:
  • Belongs to the G-alpha family. G(s) subfamily.:
    • P38405
genes like me logo Genes that share domains with GNAL: view

No data available for Gene Families for GNAL Gene

Function for GNAL Gene

Molecular function for GNAL Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein) alpha stimulating activity,olfactory type
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters

Gene Ontology (GO) - Molecular Function for GNAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAL: view
genes like me logo Genes that share phenotypes with GNAL: view

Animal Models for GNAL Gene

MGI Knock Outs for GNAL:

miRNA for GNAL Gene

miRTarBase miRNAs that target GNAL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNAL Gene

Localization for GNAL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAL Gene COMPARTMENTS Subcellular localization image for GNAL gene
Compartment Confidence
cytosol 3
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GNAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNAL Gene

Pathways for GNAL Gene

genes like me logo Genes that share pathways with GNAL: view

Gene Ontology (GO) - Biological Process for GNAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 8243272
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GNAL: view

Compounds for GNAL Gene

(5) Tocris Compounds for GNAL Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(3) HMDB Compounds for GNAL Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for GNAL Gene

Compound -log(P) Hits PubMed IDs
guanine 58 6
genes like me logo Genes that share compounds with GNAL: view

Transcripts for GNAL Gene

Unigene Clusters for GNAL Gene

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for GNAL Gene

GeneLoc Exon Structure for
GNAL
ECgene alternative splicing isoforms for
GNAL

Expression for GNAL Gene

mRNA expression in normal human tissues for GNAL Gene

mRNA differential expression in normal tissues according to GTEx for GNAL Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (9.2) and Brain - Caudate (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNAL Gene

SOURCE GeneReport for Unigene cluster for GNAL Gene Hs.136295

mRNA Expression by UniProt/SwissProt for GNAL Gene

P38405-GNAL_HUMAN
Tissue specificity: Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined
genes like me logo Genes that share expressions with GNAL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GNAL Gene

Orthologs for GNAL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAL 35
  • 99.83 (n)
  • 100 (a)
GNAL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAL 35
  • 88.6 (n)
  • 99.47 (a)
GNAL 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAL 35
  • 90.44 (n)
  • 95.54 (a)
GNAL 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnal 35
  • 87.88 (n)
  • 95.04 (a)
Gnal 16
Gnal 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAL 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAL 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnal 35
  • 88.06 (n)
  • 95.04 (a)
chicken
(Gallus gallus)
Aves GNAL 35
  • 85.05 (n)
  • 93.93 (a)
GNAL 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gnal 35
  • 80.56 (n)
  • 89.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12792 35
zebrafish
(Danio rerio)
Actinopterygii gnal 35
  • 75.99 (n)
  • 87.07 (a)
gnal2 36
  • 76 (a)
OneToOne
wufb10c03 35
fruit fly
(Drosophila melanogaster)
Insecta G-salpha60A 36
  • 68 (a)
OneToMany
Galpha73B 37
  • 38 (a)
G-salpha60A 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea gsa-1 36
  • 64 (a)
OneToMany
gsa-1 37
  • 66 (a)
gpa-5 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for GNAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAL Gene

ENSEMBL:
Gene Tree for GNAL (if available)
TreeFam:
Gene Tree for GNAL (if available)

Paralogs for GNAL Gene

Paralogs for GNAL Gene

Selected SIMAP similar genes for GNAL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GNAL: view

Variants for GNAL Gene

Sequence variations from dbSNP and Humsavar for GNAL Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs593091 -- 11,878,970(+) AGGAG(G/T)GGGGA intron-variant
rs594792 -- 11,879,343(+) GATTC(C/T)CGTGG intron-variant
rs594853 -- 11,879,398(+) TGCCC(A/G)GGCTG intron-variant
rs602198 -- 11,875,702(+) ttccc(A/G)tacag intron-variant
rs602201 -- 11,882,269(+) CAATA(A/T)GTTTC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GNAL Gene

Variant ID Type Subtype PubMed ID
nsv518207 CNV Loss 19592680
nsv516128 CNV Loss 19592680
nsv833590 CNV Gain 17160897
esv6550 CNV Gain 19470904
nsv828180 CNV Loss 20364138
dgv491e201 CNV Deletion 23290073
esv2716801 CNV Deletion 23290073
esv2716803 CNV Deletion 23290073
esv2115144 CNV Deletion 18987734
esv4523 CNV Deletion 18987735
nsv131836 CNV Loss 16902084
esv2716804 CNV Deletion 23290073
esv2672629 CNV Deletion 23128226
esv27176 CNV Loss 19812545
esv2676694 CNV Deletion 23128226
nsv909382 CNV Loss 21882294
nsv525904 CNV Loss 19592680
esv2432184 CNV Insertion 19546169
esv1495837 CNV Insertion 17803354
esv2716805 CNV Deletion 23290073
esv2668690 CNV Deletion 23128226

Relevant External Links for GNAL Gene

HapMap Linkage Disequilibrium report
GNAL
Human Gene Mutation Database (HGMD)
GNAL
Locus Specific Mutation Databases (LSDB)
GNAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNAL Gene

Disorders for GNAL Gene

(1) OMIM Diseases for GNAL Gene (139312)

UniProtKB/Swiss-Prot

GNAL_HUMAN
  • Dystonia 25 (DYT25) [MIM:615073]: A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT25 is an autosomal dominant neurologic disorder characterized by adult onset of focal dystonia, usually involving the neck. The dystonia most often progresses to involve other regions, particularly the face and laryngeal muscles, and less commonly the trunk and limbs. {ECO:0000269 PubMed:23222958}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for GNAL Gene

(5) Novoseek inferred disease relationships for GNAL Gene

Disease -log(P) Hits PubMed IDs
pseudohypoparathyroidism 70.1 1
bipolar disorder 39.4 3
mood disorders 27 1
major depression 20.6 1
schizophrenia 19.7 3

Relevant External Links for GNAL

Genetic Association Database (GAD)
GNAL
Human Genome Epidemiology (HuGE) Navigator
GNAL
genes like me logo Genes that share disorders with GNAL: view

Publications for GNAL Gene

  1. Analysis of polymorphisms in the olfactory G-protein Golf in major depression. (PMID: 11901355) Zill P. … Bondy B. (Psychiatr. Genet. 2002) 3 23
  2. Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia. (PMID: 11032382) Vuoristo J.T. … Ala-Kokko L. (Mol. Psychiatry 2000) 3 23
  3. Alternative transcripts and evidence of imprinting of GNAL on 18p11.2. (PMID: 16044173) Corradi J.P. … Furlong S.T. (Mol. Psychiatry 2005) 3 23
  4. Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder. (PMID: 17166517) Laurin N. … Barr C.L. (J Psychiatr Res 2008) 3 23
  5. Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients. (PMID: 12782961) Zill P. … Christodoulou G.N. (Psychiatr. Genet. 2003) 3 48

Products for GNAL Gene

Sources for GNAL Gene

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