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Aliases for GNAI3 Gene

Aliases for GNAI3 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 3 2 3
  • G(I) Alpha-3 3 4
  • ARCND1 3 6
  • Guanine Nucleotide-Binding Protein G(K) Subunit Alpha 3
  • 87U6 3

External Ids for GNAI3 Gene

Previous GeneCards Identifiers for GNAI3 Gene

  • GC01P110570
  • GC01P109020
  • GC01P109193
  • GC01P109390
  • GC01P109803
  • GC01P110091
  • GC01P107983

Summaries for GNAI3 Gene

Entrez Gene Summary for GNAI3 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

GeneCards Summary for GNAI3 Gene

GNAI3 (Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 3) is a Protein Coding gene. Diseases associated with GNAI3 include auriculocondylar syndrome 1 and auriculo-condylar syndrome. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAI3 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Tocris Summary for GNAI3 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAI3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAI3 Gene

Genomics for GNAI3 Gene

Regulatory Elements for GNAI3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNAI3 Gene

Start:
109,548,564 bp from pter
End:
109,618,321 bp from pter
Size:
69,758 bases
Orientation:
Plus strand

Genomic View for GNAI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAI3 Gene

Proteins for GNAI3 Gene

  • Protein details for GNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08754-GNAI3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(k) subunit alpha
    Protein Accession:
    P08754
    Secondary Accessions:
    • P17539
    • Q5TZX1

    Protein attributes for GNAI3 Gene

    Size:
    354 amino acids
    Molecular mass:
    40532 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GNAI3 Gene

neXtProt entry for GNAI3 Gene

Proteomics data for GNAI3 Gene at MOPED

Post-translational modifications for GNAI3 Gene

  • Ubiquitination at Lys35, Lys46, Lys92, Lys128, Lys192, Lys248, and Lys349
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAI3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GNAI3 Gene

Domains for GNAI3 Gene

Graphical View of Domain Structure for InterPro Entry

P08754

UniProtKB/Swiss-Prot:

GNAI3_HUMAN :
  • P08754
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAI3: view

No data available for Gene Families for GNAI3 Gene

Function for GNAI3 Gene

Molecular function for GNAI3 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 3
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Gene Ontology (GO) - Molecular Function for GNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAI3: view
genes like me logo Genes that share phenotypes with GNAI3: view

Animal Models for GNAI3 Gene

MGI Knock Outs for GNAI3:

Animal Model Products

CRISPR Products

miRNA for GNAI3 Gene

miRTarBase miRNAs that target GNAI3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAI3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNAI3 Gene

Localization for GNAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAI3 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAI3 Gene COMPARTMENTS Subcellular localization image for GNAI3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17635935
GO:0005765 lysosomal membrane IDA 17897319
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA 17635935
GO:0005834 heterotrimeric G-protein complex IBA --
genes like me logo Genes that share ontologies with GNAI3: view

Pathways for GNAI3 Gene

genes like me logo Genes that share pathways with GNAI3: view

Gene Ontology (GO) - Biological Process for GNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006810 transport NAS 2452165
GO:0006906 vesicle fusion IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with GNAI3: view

Compounds for GNAI3 Gene

(5) Tocris Compounds for GNAI3 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNAI3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNAI3: view

Transcripts for GNAI3 Gene

mRNA/cDNA for GNAI3 Gene

(566) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNAI3 Gene

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAI3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNAI3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for GNAI3 Gene

GeneLoc Exon Structure for
GNAI3
ECgene alternative splicing isoforms for
GNAI3

Expression for GNAI3 Gene

mRNA expression in normal human tissues for GNAI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAI3 Gene

SOURCE GeneReport for Unigene cluster for GNAI3 Gene Hs.73799

genes like me logo Genes that share expressions with GNAI3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAI3 Gene

Orthologs for GNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAI3 35
  • 99.62 (n)
  • 100 (a)
GNAI3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAI3 35
  • 95.39 (n)
  • 98.87 (a)
GNAI3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAI3 35
  • 96.05 (n)
  • 98.87 (a)
GNAI3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai3 35
  • 93.5 (n)
  • 98.31 (a)
Gnai3 16
Gnai3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAI3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnai3 35
  • 92.47 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves GNAI3 35
  • 81.07 (n)
  • 94.92 (a)
GNAI3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAI3 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnai3 35
  • 79 (n)
  • 93.5 (a)
zebrafish
(Danio rerio)
Actinopterygii gnai3 35
  • 77.87 (n)
  • 90.68 (a)
gnai3 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 77 (a)
OneToMany
Galpha73B 37
  • 35 (a)
G-ialpha65A 37
  • 76 (a)
G-oalpha47A 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea odr-3 37
  • 48 (a)
gpa-14 37
  • 31 (a)
gpa-6 37
  • 38 (a)
gpa-4 37
  • 61 (a)
goa-1 37
  • 70 (a)
gpa-10 37
  • 36 (a)
gpa-15 37
  • 43 (a)
gpa-8 37
  • 39 (a)
gpa-3 37
  • 51 (a)
gpa-9 37
  • 36 (a)
gpa-1 37
  • 44 (a)
gpa-7 37
  • 54 (a)
gpa-11 37
  • 40 (a)
gpa-2 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 36
  • 82 (a)
OneToMany
Species with no ortholog for GNAI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAI3 Gene

ENSEMBL:
Gene Tree for GNAI3 (if available)
TreeFam:
Gene Tree for GNAI3 (if available)

Paralogs for GNAI3 Gene

Paralogs for GNAI3 Gene

Selected SIMAP similar genes for GNAI3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNAI3: view

Variants for GNAI3 Gene

Sequence variations from dbSNP and Humsavar for GNAI3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3525 -- 109,594,224(+) TATTC(A/T)GTAAT utr-variant-3-prime
rs7371 -- 109,592,686(+) TTAAG(A/G)TTTTT utr-variant-3-prime
rs493821 -- 109,587,299(+) TACAA(A/G)GGTAA intron-variant
rs495562 -- 109,571,989(+) aggga(C/G)ccctg intron-variant
rs502069 -- 109,581,626(+) ctcac(A/G)cctgt intron-variant

Relevant External Links for GNAI3 Gene

HapMap Linkage Disequilibrium report
GNAI3
Human Gene Mutation Database (HGMD)
GNAI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GNAI3 Gene

Disorders for GNAI3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GNAI3 Gene including...

Search for GNAI3 Gene in MalaCards »

(1) OMIM Diseases for GNAI3 Gene (139370)

UniProtKB/Swiss-Prot

GNAI3_HUMAN
  • Auriculocondylar syndrome 1 (ARCND1) [MIM:602483]: An autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. {ECO:0000269 PubMed:22560091}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GNAI3

Genetic Association Database (GAD)
GNAI3
Human Genome Epidemiology (HuGE) Navigator
GNAI3
genes like me logo Genes that share disorders with GNAI3: view

Publications for GNAI3 Gene

  1. Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. (PMID: 3109953) Didsbury J.R. … Snyderman R. (FEBS Lett. 1987) 2 3 4
  2. A small multigene family encodes Gi signal-transduction proteins. (PMID: 3120178) Beals C.R. … Perlmutter R.M. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  3. Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. (PMID: 3132707) Kim S. … Neer E.J. (Proc. Natl. Acad. Sci. U.S.A. 1988) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The human genome encodes at least three non-allelic G proteins with alpha i-type subunits. (PMID: 2440724) Suki W.N. … Birnbaumer L. (FEBS Lett. 1987) 3 4

Products for GNAI3 Gene

Sources for GNAI3 Gene

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