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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAI2 Gene

protein-coding   GIFtS: 69
GCID: GC03P050263

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...


(Previous symbol: GNAI2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 21 2
     H_LUCA15.12
GNAI2B1 2 3 5     H_LUCA16.12
GTP-Binding Regulatory Protein Gi Alpha-2 Chain1 2     Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-22
Adenylate Cyclase-Inhibiting G Alpha Protein2 3     Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit2
GIP2 5     

External Ids:    HGNC: 43851   Entrez Gene: 27712   Ensembl: ENSG000001143537   OMIM: 1393605   UniProtKB: P048993   

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNAI2 Gene:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The
encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of
adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for GNAI2 Gene: 
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) is a protein-coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic, and functioning pituitary adenoma, and among its related super-pathways are G-protein mediated events and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
intracellular pool

summary for GNAI2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAI2 gene promoter:
         SRF   CHOP-10   GR   Sp1   SRF (504 AA)   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNAI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Start:
50,263,724 bp from pter      End:
50,296,787 bp from pter
Size:
33,064 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2  
Size: 355 amino acids; 40451 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with
UNC5B
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell
membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow
and/or the midbody
Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71
Alternative splicing: 4 isoforms:  P04899-1   P04899-2   P04899-3   P04899-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Explore proteomics data for GNAI2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04899

  • GNAI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNAI2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1  

    ENSEMBL proteins: 
     ENSP00000406871   ENSP00000406065   ENSP00000312999   ENSP00000394321   ENSP00000395736  
     ENSP00000406369   ENSP00000266027   ENSP00000444360  
    Reactome Protein details: P04899
    Human Recombinant Protein Products for GNAI2: 
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    Novus Biologicals GNAI2 Proteins
    Novus Biologicals GNAI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GNAI2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17635935
    GO:0005813centrosome IDA17635935
    GO:0005829cytosol IEA--
    GO:0005834heterotrimeric G-protein complex IBA--

    GNAI2 for ontologies           About GeneDecksing



    GNAI2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P04899

    ProtoNet protein and cluster: P04899

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    GNAI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
    Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
    intracellular pool

         Genatlas biochemistry entry for GNAI2:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    GNAI2 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gnai2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton  tumorigenesis 

    GNAI2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GNAI2: Gnai2tm1Lbi Gnai2tm1Rmm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNAI2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNAI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAI2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAI2 

    miRNA
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    miRTarBase miRNAs that target GNAI2:
    hsa-mir-30a (MIRT005181), hsa-mir-30d (MIRT003274)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAI2
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNAI2 About   (see all 81)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    4Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    5Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/23 EMD Millipore Pathways for GNAI2 (see all 23)
        Chemotaxis CXCR4 signaling pathway
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Integrin inside-out signaling
    Development G-Proteins mediated regulation MARK-ERK signaling

    57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI2 (see first 5)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    ERK5 Signaling
    P2Y Receptor Signaling
    Actin Nucleation and Branching
    Human Embryonic Stem Cell Pluripotency
    Rho Family GTPases
    Alpha-Adrenergic Signaling
    Beta-Adrenergic Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Hedgehog Signaling in Mammals
    Activation of PKA through GPCR
    S-1P Stimulated Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    CRHR Pathway
    Estrogen Pathway
    Thrombin Signaling
    cAMP Pathway
    NgR-p75(NTR)-Mediated Signaling
    Phospholipase-C Pathway
    Activation of cAMP-Dependent PKA
    fMLP Pathway
    MAPK Signaling
    PKA Signaling
    G-Beta Gamma Signaling
    Actin-Based Motility by Rho Family GTPases
    Relaxin Pathway
    Androgen Signaling
    Endothelin-1 Signaling Pathway
    G-AlphaI Signaling
    Activation of PKC through GPCR
    Signaling in Gap Junctions
    Signaling Involved in Cardiac Hypertrophy
    Transendothelial Migration of Leukocytes
    AMPK Enzyme Complex Pathway
    Melatonin Signaling
    eNOS Signaling
    CREB Pathway
    IP3 Pathway
    Sperm Motility
    Akt Signaling
    CXCR4 Pathway
    NFAT and Cardiac Hypertrophy
    Actin Nucleation by ARP-WASP Complex
    EphB-EphrinB Signaling
    Breast Cancer Regulation by Stathmin1
    ERK Signaling
    p70S6K Signaling
    GnRH Signaling
    GPCR Pathway
    Huntington's Disease Pathway
    p38 Signaling
    GHRH Signaling
    WNT Signaling

    5/25 GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/13 BioSystems Pathways for GNAI2 (see all 13)
        G Protein Signaling Pathways
    Signal Transduction of S1P Receptor
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway
    CXCR3-mediated signaling events

    5/24        Reactome Pathways for GNAI2 (see all 24)
        Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion
    Neuronal System
    Opioid Signalling

    3 PharmGKB Pathways for GNAI2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/23         Kegg Pathways  (Kegg details for GNAI2) (see all 23):
        Chemokine signaling pathway
    Axon guidance
    Tight junction
    Gap junction
    Leukocyte transendothelial migration


    GNAI2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/351 Interacting proteins for GNAI2 (P048991, 2, 3 ENSP000003129994) via UniProtKB, MINT, STRING, and/or I2D (see all 351)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF2P198782, 3, ENSP000003565054MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
    NCF1P145982, 3, ENSP000002894734MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
    MAP3K3Q997592, 3, ENSP000003549274MINT-48437 I2D: score=2 STRING: ENSP00000354927
    GNB1P628732, 3, ENSP000003678724MINT-7135221 I2D: score=1 STRING: ENSP00000367872
    HSP90AB1P082382, 3MINT-72645 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001973adenosine receptor signaling pathway IBA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS7961880
    GO:0007186G-protein coupled receptor signaling pathway TAS8587610

    GNAI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNAI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GNAI2 gene (6 alternative transcripts): 
    NM_001166425.1  NM_001282617.1  NM_001282618.1  NM_001282619.1  NM_001282620.1  NM_002070.3  

    Unigene Cluster for GNAI2:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
    Hs.77269  [show with all ESTs]
    Unigene Representative Sequence: AK126708
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100
    ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)
    ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422
    ENST00000492383 ENST00000266027 ENST00000536647
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
    Sirion Biotech Customized lentivirus for stable overexpression of GNAI2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
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    Additional mRNA sequence: 

    AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1 
    AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1 

    24/42 DOTS entries (see all 42):

    DT.100680604  DT.97768608  DT.75112974  DT.99968212  DT.91784324  DT.97860778  DT.100680607  DT.100057602 
    DT.95357437  DT.97800888  DT.100059846  DT.100862119  DT.91784320  DT.100059845  DT.120873963  DT.100680601 
    DT.95214674  DT.100648169  DT.100680617  DT.120873971  DT.95185336  DT.120874020  DT.100042317  DT.100859294 

    24/1325 AceView cDNA sequences (see all 1325):

    BU626280 AI824708 CD613961 CR604433 CA449568 BI032154 AA376085 AL534767 
    BC014627 BU501565 BF726024 AI631364 BU501163 M78045 AI278009 AW062609 
    BU543734 BM673245 AI863251 BE764177 AK096595 CF272190 BF969404 BU849534 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:              -     -     -     -     -     -     -     -                       -                                         -                                 
    SP2:                                            -     -     -     -                 -                                         -                                 
    SP3:              -     -     -     -     -     -     -     -     -                 -                                         -                                 
    SP4:                          -     -     -     -     -     -     -                 -                                         -                                 
    SP5:                                            -     -     -     -     -           -                                         -                                 

    ExUns: 15f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GNAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAI2 expression in normal human tissues (normalized intensities)      GNAI2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGAA
    GNAI2 Expression
    About this image


    GNAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal cord/lateral wall/ventricular layer   

    See GNAI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAI2

    SOURCE GeneReport for Unigene cluster: Hs.77269
        SABiosciences Expression via Pathway-Focused PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNAI2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai21 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 91.74(n)1
    98.31(a)1
      9 (58.43 cM)5
    146781  NM_008138.41  NP_032164.21 
     1076141385 
    chicken
    (Gallus gallus)
    Aves GNAI21 guanine nucleotide binding protein (G protein), alpha more 87.32(n)
    95.21(a)
      396367  NM_205402.1  NP_990733.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    2(148689899-148811953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215122 Xenopus laevis guanine nucleotide-binding protein Gi more 83.72(n)    AF086606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi21e062 wufi21e06 82.55(n)   327650  BC049343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A3 G-protein coupled receptor protein
    signaling pathway more
    76(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA11 Gpa1p 53.61(n)
    48.49(a)
      856394   NP_011868.1 


    ENSEMBL Gene Tree for GNAI2 (if available)
    TreeFam Gene Tree for GNAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAI2 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):
    GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    GNAI2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GNAI2
    PGOHUM00000238547 PGOHUM00000239685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 SNPs in GNAI2 are shown (see all 400)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378532261,2
    Cother150226052(+) GGACCC/G/TGCGTA 6 R G C mis10--------
    rs1491184511,2
    --50204022(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1448643071,2
    --50204071(+) GTCTCC/GATCTC 1 -- us2k10--------
    rs1387130991,2
    --50204100(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1403390471,2
    --50204135(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1454012131,2
    --50204225(+) AACCTC/GCGCCT 1 -- us2k10--------
    rs1924020711,2
    --50204275(+) AGCTGC/GGATTA 1 -- us2k10--------
    rs1474273381,2
    --50204290(+) TGCCCA/GCCACC 1 -- us2k10--------
    rs1483276661,2
    --50204432(+) CAACCA/GTGCCC 1 -- us2k10--------
    rs1154094271,2
    F--50204464(+) TCTAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for GNAI2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1008898CNV Deletion20482838
    dgv5132n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    dgv602n27CNV Loss19166990
    nsv470561CNV Loss18288195
    nsv460531CNV Loss19166990
    nsv523560CNV Loss19592680
    nsv523662CNV Loss19592680
    dgv5131n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): GNAI2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139360   
    OMIM disorders: 192605  
    20/26 diseases for GNAI2 (see all 26):    About MalaCards
    ventricular tachycardia, idiopathic    functioning pituitary adenoma    non-functioning pituitary adenoma    olivopontocerebellar atrophy
    noonan syndrome    trypanosomiasis    fainting    chagas disease
    toxoplasmosis    pituitary adenoma    pertussis    hiv type 1
    adenoma    huntington's disease    insulin resistance    neuroblastoma
    hypertension    multiple sclerosis    schizophrenia    retinitis


    GNAI2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNAI2
    Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

    Export disorders for GNAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAI2 gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with GNAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)1, 2, 3 Didsbury J.R.... Snyderman R. (1987)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    4. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)1, 4 Ruggeri R.M....CannavA^ S. (2008)
    5. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)1, 2 Lopez-Aranda M.F.... Khan Z.U. (2007)
    6. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (2007)
    7. The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)1, 4 Menzaghi C....Trischitta V. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2771 HGNC: 4385 AceView: GNAI2 Ensembl:ENSG00000114353 euGenes: HUgn2771
    ECgene: GNAI2 Kegg: 2771 H-InvDB: GNAI2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNAI2 gene:
    Search GeneIP for patents involving GNAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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