GNAI2 Gene

Aliases
for GNAI2 gene

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239

Summaries
for GNAI2 gene

Genomic Views
for GNAI2 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: GNAI2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI2

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Proteins
for GNAI2 gene

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: GNAI2 OriGene Protein Over-expression Lysate: GNAI2 OriGene Custom Protein Services for GNAI2
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	Novus Biologicals GNAI2 Proteins Novus Biologicals GNAI2 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for GNAI2
	Uscn Proteins for GNAI2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
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	ThermoFisher Antibody for GNAI2

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GNAI2

Protein Domains /
Families
for GNAI2 gene

ProtoNet protein and cluster: P04899

Function
for GNAI2 gene

miRNA Products:		miRTarBase miRNAs that target GNAI2: hsa-mir-30a (MIRT005181), hsa-mir-30d (MIRT003274)
		OriGene 3'-UTR Clone: GNAI2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAI2
		8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI2 (see all 68):
		hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
		SwitchGear 3'UTR luciferase reporter plasmid: GNAI2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAI2 (see all 7) OriGene shRNA RFP: GNAI2 OriGene siRNA: GNAI2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAI2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GNAI2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNAI2
		Search LifeMap BioReagents cell lines for GNAI2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

(inferred from 4 alleles) (MGI details for Gnai2)

Pathways & Interactions
for GNAI2 gene

	Super-pathway	contained gene-specific pathways
1	Development Angiotensin activation of ERK	8/9 pathways (see all 9) Development Angiotensin activation of ERK 1.00 Development G-Proteins mediated regulation MARK-ERK signaling 0.66 Development_Angiotensin activation of ERK 0.98 Development_EDNRB signaling 0.54 Development_ACM2 and ACM4 activation of ERK 0.74 Development EDNRB signaling 0.54 Development ACM2 and ACM4 activation of ERK 0.74 Cholinergic synapse 0.30
2	Development_Dopamine D2 receptor transactivation of EGFR	Development_Dopamine D2 receptor transactivation of EGFR 1.00 Development Alpha-2 adrenergic receptor activation of ERK 0.66 Development Dopamine D2 receptor transactivation of EGFR 1.00 Chemotaxis_CXCR4 signaling pathway 0.48 Development_Alpha-2 adrenergic receptor activation of ERK 0.66 Chemotaxis CXCR4 signaling pathway 0.48
3	Opioid Signalling	Opioid Signalling 1.00 Beta-agonist/Beta-blocker Pathway, Pharmacodynamics 0.35 G-protein mediated events 0.55 Glutamatergic synapse 0.31 PLC beta mediated events 0.54
4	G Protein Signaling Pathways	G Protein Signaling Pathways 1.00 Signal transduction_PKA signaling 0.23 Signal transduction cAMP signaling 0.44 Signal transduction PKA signaling 0.23 Signal transduction_cAMP signaling 0.44
5	G-Beta Gamma Signaling	G-Beta Gamma Signaling 1.00 Relaxin Pathway 0.32 GHRH Signaling 0.46 Hedgehog Signaling in Mammals 0.22 CRHR Pathway 0.44

5/23 EMD Millipore Pathways for GNAI2

	Chemotaxis CXCR4 signaling pathway
	Development A1 receptor signaling
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Integrin inside-out signaling
	Development G-Proteins mediated regulation MARK-ERK signaling

5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI2

	RhoA Pathway
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	CDK5 Pathway

5/25 GeneGo (Thomson Reuters) Pathways for GNAI2

	Signal transduction cAMP signaling
	Development Endothelin-1/EDNRA signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

5/13 BioSystems Pathways for GNAI2

	Signal Transduction of S1P Receptor
	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways
	TSH signaling pathway
	S1P4 pathway

5/24        Reactome Pathways for GNAI2

	Transmission across Chemical Synapses
	Metabolism
	Regulation of Insulin Secretion
	Neuronal System
	Opioid Signalling

3 PharmGKB Pathways for GNAI2

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

5/14         Kegg Pathways  (Kegg details for GNAI2)

	Chemokine signaling pathway
	Axon guidance
	Tight junction
	Gap junction
	Leukocyte transendothelial migration

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

Drugs & Compounds
for GNAI2 gene

Transcripts
for GNAI2 gene

Expression
for GNAI2 gene

GNAI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTATGGAA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
	BrainMedulla Oblongata			Brain
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
	Spinal CordPresumptive Spinal Cord			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAI2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAI2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

Orthologs
for GNAI2 gene

Paralogs
for GNAI2 gene

Paralogs for GNAI2 gene

GNAQ²  GNA14²  GNA11²  GNAI3²  GNAT2²  GNA13²  GNAT3²  GNAT1²  

GNA15²  GNA12²  GNAZ²  GNAI1²  GNAO1²  

18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):

GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1

GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12

GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

GNAI2 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for GNAI2
PGOHUM00000238547 PGOHUM00000239685

Genomic Variants
for GNAI2 gene

10/320 NCBI SNPs in GNAI2 are shown (see all 320)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1378532261,2	C	other	82185941(+)	GGACCC/G/TGCGTA	6	R G C	mis1		0	--	--	--	--
rs1491184511,2		--	50271665(+)	GCTAAC/TTTTTT	1	--	us2k1		0	--	--	--	--
rs1448643071,2		--	50271714(+)	GTCTCC/GATCTC	1	--	us2k1		0	--	--	--	--
rs1387130991,2		--	50271743(+)	GCCTCA/GGCCTC	1	--	us2k1		0	--	--	--	--
rs1403390471,2		--	50271778(+)	GCCACC/TGTGCC	1	--	us2k1		0	--	--	--	--
rs1454012131,2		--	50271868(+)	AACCTC/GCGCCT	1	--	us2k1		0	--	--	--	--
rs1924020711,2		--	50271918(+)	AGCTGC/GGATTA	1	--	us2k1		0	--	--	--	--
rs1474273381,2		--	50271933(+)	TGCCCA/GCCACC	1	--	us2k1		0	--	--	--	--
rs1483276661,2		--	50272075(+)	CAACCA/GTGCCC	1	--	us2k1		0	--	--	--	--
rs1154094271,2	F,	--	50272107(+)	TCTAAG/AGAAGG	1	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GNAI2
     5 CNVs: 30176 4335 3429 53228 4336
Human Gene Mutation Database (HGMD): GNAI2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAI2

DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

Disorders / Diseases
for GNAI2 gene

Publications
for GNAI2 gene

PubMed articles for GNAI2 gene, integrated from 9 sources (see all 125) (see top 10): (articles sorted by number of sources associating them with GNAI2)

Utopia: connect your pdf to the dynamic world of online information

1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)^{1, 2, 3} Didsbury J.R.... Snyderman R. (1987)
2. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)^{1, 2} Lopez-Aranda M.F.... Khan Z.U. (2007)
3. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)^{1, 2} Cho H. and Kehrl J.H. (2007)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)^{1, 2} Komatsuzaki K.... Kinane T.B. (2002)
7. Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PubMed id 1733849)^{1, 3} Magovcevic I....Morton C.C. (1992)
8. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)^{1, 2} Itoh H.... Kaziro Y. (1988)
9. Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. (PubMed id 2837412)^{1, 2} Weinstein L.S.... Carter A.D. (1988)
10. A small multigene family encodes Gi signal-transduction proteins. (PubMed id 3120178)^{1, 2} Beals C.R.... Perlmutter R.M. (1987)
11. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
12. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
13. Guanine nucleotide-binding protein Gai2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. (PubMed id 22333621)¹ Luissint A.C....Couraud P.O. (2012)
14. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
15. HIV-1 Nef impairs heterotrimeric G-protein signaling b y targeting Ga(i2) for degradation through ubiquitination. (PubMed id 23071112)¹ Chandrasekaran P....Venkatesan S. (2012)
16. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
17. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
18. Heterotrimeric Gi/Go proteins modulate endothelial TL R signaling independent of the MyD88-dependent pathway. (PubMed id 21949112)¹ Dauphinee S.M....Karsan A. (2011)
19. A QUICK screen for Lrrk2 interaction partners--leucine -rich repeat kinase 2 is involved in actin cytoskeleton dynamics. (PubMed id 20876399)¹ Meixner A....Ueffing M. (2011)
20. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
21. G alpha i2 and ZAP-70 mediate RasGRP1 membrane locali zation and activation of SDF-1-induced T cell functions. (PubMed id 21856938)¹ Kremer K.N....Hedin K.E. (2011)
22. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
23. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
24. Identification and experimental validation of G prote in alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. (PubMed id 21079996)¹ Jiang L....Zhou X. (2011)
25. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
26. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
27. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)¹ So H.C....Sham P.C. (2009)
28. GNAI2 and regulators of G protein signaling as a pote ntial Noonan syndrome mechanism. (PubMed id 19282110)¹ Huang X....Neubig R.R. (2009)
29. Purification and functional reconstitution of monomer ic mu-opioid receptors: allosteric modulation of agonist binding by Gi2. (PubMed id 19542234)¹ Kuszak A.J....Sunahara R.K. (2009)
30. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
31. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)¹ Luttrell L.M. (2008)
32. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)¹ Ruggeri R.M....CannavA^ S. (2008)
33. The specific activation of TRPC4 by Gi protein subtype. (PubMed id 18854172)¹ Jeon J.P....So I. (2008)
34. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)¹ Lambert N.A. (2008)
35. Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. (PubMed id 18940181)¹ Quan W....Kim K.M. (2008)
36. Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. (PubMed id 18453587)¹ Cheung R....Collman R.G. (2008)
37. Purification and identification of G protein-coupled receptor protein complexes under native conditions. (PubMed id 17215244)¹ Daulat A.M....Jockers R. (2007)
38. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
39. Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors. (PubMed id 16371464)¹ Gibson S.K. and Gilman A.G. (2006)
40. Mechanism of the receptor-catalyzed activation of het erotrimeric G proteins. (PubMed id 16892066)¹ Oldham W.M....Hamm H.E. (2006)
41. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
42. G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). (PubMed id 16298104)¹ Willard F.S....Siderovski D.P. (2006)
43. The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)¹ Menzaghi C....Trischitta V. (2006)
44. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
45. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
46. Real-time monitoring of receptor and G-protein interactions in living cells. (PubMed id 15782186)¹ Gales C....Bouvier M. (2005)
47. HIV type 1 glycoprotein 120 inhibits human B cell che motaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL 21. (PubMed id 15972662)¹ Badr G....Richard Y. (2005)
48. Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. (PubMed id 15640523)¹ Arinze I.J. and Kawai Y. (2005)
49. Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects. (PubMed id 15331550)¹ Richardson M.D....Kwatra M.M. (2004)
50. Abnormal regulation of G protein alpha(i2) subunit in skin fibroblasts from insulin-resistant hypertensive individuals. (PubMed id 15126921)¹ Baritono E....Semplicini A. (2004)
51. Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization. (PubMed id 14701866)¹ Holstein D.M....Saunders C. (2004)
52. Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods. (PubMed id 15047060)¹ Bernhard O.K....Sheil M.M. (2004)
53. Distribution of C-terminal splice variant of G alpha i2 in rat and monkey brain. (PubMed id 15312896)¹ Khan Z.U. and Gutierrez A. (2004)
54. CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins. (PubMed id 15251452)¹ Mueller A. and Strange P.G. (2004)
55. Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. (PubMed id 12860983)¹ Wakasugi K....Morishima I. (2003)
56. Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness. (PubMed id 14623802)¹ Welzig C.M....Galper J.B. (2003)
57. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. (PubMed id 12509430)¹ Tall G.G....Gilman A.G. (2003)
58. RGS16 inhibits signalling through the G alpha 13-Rho axis. (PubMed id 14634662)¹ Johnson E.N....Druey K.M. (2003)
59. Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. (PubMed id 12748287)¹ Marty C....Ye R.D. (2003)
60. Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. (PubMed id 12624107)¹ Arinze I.J. and Kawai Y. (2003)
61. Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. (PubMed id 11950062)¹ Ozaki H....Kawakami K. (2002)
62. Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently. (PubMed id 12068084)¹ Massotte D....Milligan G. (2002)
63. Cloning and characterization of a novel regulator of G protein signalling in human platelets. (PubMed id 11955952)¹ Gagnon A.W.... Leadley R.J. Jr. (2002)
64. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
65. Isoforms of mammalian adenylyl cyclase: multiplicitie s of signaling. (PubMed id 14993377)¹ Sunahara R.K. and Taussig R. (2002)
66. Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway. (PubMed id 12088413)¹ Nanki T. and Lipsky P.E. (2001)
67. CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. (PubMed id 11168387)¹ Mukhopadhyay S. and Howlett A.C. (2001)
68. Specific involvement of G(alphai2) with epidermal growth factor receptor signaling in rat hepatocytes, and the inhibitory effect of chronic ethanol. (PubMed id 11286993)¹ Zhang B.H....Farrell G.C. (2001)
69. Stimulation by n6-cyclopentyladenosine of A1 adenosine receptors, coupled to galphai2 protein subunit, has a capacitative effect on human spermatozoa. (PubMed id 11369591)¹ Allegrucci C....Minelli A. (2001)
70. Characterization of RGS5 in regulation of G protein-coupled receptor signaling. (PubMed id 11253162)¹ Zhou J....Kimura S. (2001)
71. Identification of the platelet ADP receptor targeted by antithrombotic drugs. (PubMed id 11196645)¹ Hollopeter G....Conley P.B. (2001)
72. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. (PubMed id 11387333)¹ Kimple R.J....Siderovski D.P. (2001)
73. Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth. (PubMed id 11120746)¹ Kuemmerle J.F. and Murthy K.S. (2001)
74. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. (PubMed id 10906137)¹ Fan X.... Manning D.R. (2000)
75. Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. (PubMed id 11055978)¹ Hansen J.L....Sheikh S.P. (2000)
76. PAR1 thrombin receptor-G protein interactions. Separation of binding and coupling determinants in the galpha subunit. (PubMed id 10644723)¹ Swift S....Kuliopulos A. (2000)
77. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PubMed id 10727522)¹ Im D.-S.... Lynch K.R. (2000)
78. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1). (PubMed id 11118617)¹ Caricasole A.... Terstappen G.C. (2000)
79. Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration. (PubMed id 10840027)¹ Cismowski M.J....Duzic E. (2000)
80. Coupling of dopamine receptor subtypes to multiple and diverse G proteins. (PubMed id 10978845)¹ Sidhu A. and Niznik H.B. (2000)
81. The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2. (PubMed id 10493819)¹ Kuhn B. and Gudermann T. (1999)
82. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. (PubMed id 10598579)¹ Brydon L....Jockers R. (1999)
83. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. (PubMed id 10471929)¹ Cismowski M.J.... Duzic E. (1999)
84. Association of the proto-oncogene product dbl with G protein betagamma subunits. (PubMed id 10518015)¹ Nishida K....Satoh T. (1999)
85. Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. (PubMed id 9660808)¹ Druey K.M....Kehrl J.H. (1998)
86. Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2. (PubMed id 9637720)¹ Lerman B.B....Catanzaro D.F. (1998)
87. The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. (PubMed id 9647645)¹ Lin P....Farquhar M.G. (1998)
88. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. (PubMed id 9079700)¹ Chen C....Lin S.C. (1997)
89. Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. (PubMed id 9092559)¹ Krieger-Brauer H.I....Kather H. (1997)
90. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. (PubMed id 8663226)¹ Herrlich A....Gudermann T. (1996)
91. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. (PubMed id 8621645)¹ Song K.S....Lisanti M.P. (1996)
92. Physical association of Gi2alpha with interleukin-8 receptors. (PubMed id 8662698)¹ Damaj B.B....Naccache P.H. (1996)
93. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. (PubMed id 8552586)¹ Laugwitz K.L....Schultz G. (1996)
94. Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. (PubMed id 8903513)¹ Damaj B.B....Naccache P.H. (1996)
95. Insulin action impaired by deficiency of the G-protein subunit G ialpha2. (PubMed id 8587610)¹ Moxham C.M. and Malbon C.C. (1996)
96. Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells. (PubMed id 8982657)¹ Ogino Y....Shimizu N. (1996)
97. Identification and subcellular distribution of the Gi-proteins in the enterocytic-differentiated adenocarcinoma cell-line, Caco-2. (PubMed id 9237368)¹ Lacombe C....Paris H. (1996)
98. The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. (PubMed id 8663053)¹ Zhang J. and Pratt R.E. (1996)
99. Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton. (PubMed id 8663057)¹ Sarndahl E....Andersson T. (1996)
100. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. (PubMed id 8973305)¹ Mochizuki N.... Insel P.A. (1996)
101. GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. (PubMed id 8986788)¹ de Vries L.... Farquhar M.G. (1996)
102. Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors. (PubMed id 7882989)¹ Takigawa M....Goto K. (1995)
103. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. (PubMed id 8521505)¹ Wall M.A....Sprang S.R. (1995)
104. Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. (PubMed id 7887906)¹ Grassie M.A. and Milligan G. (1995)
105. G-protein mutations in human pituitary adrenocorticotrophic hormone- secreting adenomas. (PubMed id 7737262)¹ Williamson E.A....Harris P.E. (1995)
106. The human platelet ADP receptor activates Gi2 proteins. (PubMed id 8554519)¹ Ohlmann P....Gachet C. (1995)
107. Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11. (PubMed id 8190105)¹ Offermanns S....Jakobs K.H. (1994)
108. Stabilization of C5a receptor--G-protein interactions through ligand binding. (PubMed id 7962171)¹ Wennogle L.P....Hu S.I. (1994)
109. Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha. (PubMed id 7961880)¹ Migeon J.C....Nathanson N.M. (1994)
110. Structural determinants for activation of the alpha-s ubunit of a heterotrimeric G protein. (PubMed id 8208289)¹ Lambright D.G....Sigler P.B. (1994)
111. Mechanism of GTP hydrolysis by G-protein alpha subunits. (PubMed id 7937899)¹ Kleuss C....Gilman A.G. (1994)
112. Elevated stimulatory and reduced inhibitory G protein alpha subunits in cerebellar cortex of patients with dominantly inherited olivopontocerebellar atrophy. (PubMed id 8473899)¹ Kish S.J....Warsh J.J. (1993)
113. Analysis of the expression of seven G protein alpha subunit genes in hematopoietic cells. (PubMed id 8362897)¹ Matsuoka M....Ogata E. (1993)
114. Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. (PubMed id 8098045)¹ Valet P....Denis C. (1993)
115. Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. (PubMed id 1671672)¹ Offermanns S....Rosenthal W. (1991)
116. Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor. (PubMed id 1718802)¹ Cormont M....Sharp G.W. (1991)
117. The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2. (PubMed id 2169434)¹ McClue S.J. and Milligan G. (1990)

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