Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GNAI2 Gene

protein-coding   GIFtS: 69
GCID: GC03P050263

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...


(Previous symbol: GNAI2B)
  See GNAI2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 21 2
     H_LUCA15.12
GNAI2B1 2 3 5     H_LUCA16.12
GTP-Binding Regulatory Protein Gi Alpha-2 Chain1 2     Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-22
Adenylate Cyclase-Inhibiting G Alpha Protein2 3     Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit2
GIP2 5     

External Ids:    HGNC: 43851   Entrez Gene: 27712   Ensembl: ENSG000001143537   OMIM: 1393605   UniProtKB: P048993   

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GNAI2 Gene:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The
encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of
adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for GNAI2 Gene:
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) is a protein-coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic, and acth-secreting pituitary adenoma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
intracellular pool

summary for GNAI2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAI2 gene promoter:
         SRF   CHOP-10   GR   Sp1   SRF (504 AA)   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI2 promoter sequence
   Search Chromatin IP Primers for GNAI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Start:
50,263,724 bp from pter      End:
50,296,787 bp from pter
Size:
33,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2  
Size: 355 amino acids; 40451 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with
UNC5B
Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71
Alternative splicing: 4 isoforms:  P04899-1   P04899-2   P04899-3   P04899-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Explore proteomics data for GNAI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys46, Lys193, Lys198, Lys249, Lys296, Lys307, Lys350
  • Modification sites at PhosphoSitePlus

  • See GNAI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1  

    ENSEMBL proteins: 
     ENSP00000406871   ENSP00000406065   ENSP00000312999   ENSP00000394321   ENSP00000395736  
     ENSP00000406369   ENSP00000266027   ENSP00000444360  
    Reactome Protein details: P04899

    GNAI2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GNAI2
    OriGene Protein Over-expression Lysate for GNAI2
    OriGene MassSpec for GNAI2
    OriGene Custom Protein Services for GNAI2
    GenScript Custom Purified and Recombinant Proteins Services for GNAI2
    Novus Biologicals GNAI2 Proteins
    Novus Biologicals GNAI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GNAI2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNAI2 

     
    antibodies-online proteins for GNAI2 (12 products) 

     
    antibodies-online peptides for GNAI2

    GNAI2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GNAI2
    OriGene Custom Antibody Services for GNAI2
    Novus Biologicals GNAI2 Antibodies
    Abcam antibodies for GNAI2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GNAI2
    antibodies-online antibodies for GNAI2 (39 products) 

    GNAI2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of GNAI2
    OriGene Custom Assay Services for GNAI2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNAI2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNAI2 
    antibodies-online kits for GNAI2 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P04899

    ProtoNet protein and cluster: P04899

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Find genes that share domains with GNAI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
    Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
    intracellular pool

         Genatlas biochemistry entry for GNAI2:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with GNAI2           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gnai2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with GNAI2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GNAI2: Gnai2tm1Lbi Gnai2tm1Rmm

       genOway: Develop your customized and physiologically relevant rodent model for GNAI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNAI2:
    hsa-mir-30e-5p (MIRT044144), hsa-mir-1 (MIRT023620), hsa-mir-935 (MIRT036699), hsa-mir-30a-5p (MIRT005181), hsa-mir-30d-5p (MIRT003274), hsa-mir-124-3p (MIRT022392), hsa-mir-148b-3p (MIRT043588), hsa-mir-92b-3p (MIRT040616), hsa-mir-877-3p (MIRT036851)

    Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNAI2

    Clone
    Products:
         
    OriGene clones in human, mouse for GNAI2 (see all 11)
    OriGene ORF clones in mouse, rat for GNAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNAI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GNAI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GNAI2_HUMAN, P04899: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell
    membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow
    and/or the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17635935
    GO:0005829cytosol IEA--

    Find genes that share ontologies with GNAI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GNAI2 About   (see all 83)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 120.74
    G alpha (z) signalling events0.47
    G-protein activation0.74
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    4Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    5G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44


    Find genes that share SuperPaths with GNAI2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNAI2 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for GNAI2 (see all 14)
        Signal Transduction of S1P Receptor
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone
    TSH signaling pathway

    Selected Reactome Pathways for GNAI2 (see all 9)
        Regulation of insulin secretion
    G alpha (z) signalling events
    G-protein activation
    Adenylate cyclase inhibitory pathway
    PLC beta mediated events

    3 PharmGKB Pathways for GNAI2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNAI2) (see all 27):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Adrenergic signaling in cardiomyocytes
    Axon guidance
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAI2 (P048991, 2, 3 ENSP000003129994) via UniProtKB, MINT, STRING, and/or I2D (see all 390)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145981, 2, 3, ENSP000002894734EBI-353997,EBI-395044 MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
    GNB1P628732, 3, ENSP000003678724MINT-7135221 I2D: score=1 STRING: ENSP00000367872
    HSP90AB1P082382, 3MINT-72645 I2D: score=3 
    NCF2P198781, 2, 3, ENSP000003565054EBI-353997,EBI-489611 MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
    CXCR5P323022, 3, ENSP000002921744MINT-50704 MINT-50707 I2D: score=1 STRING: ENSP00000292174
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001973adenosine receptor signaling pathway IBA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS7961880
    GO:0007186G-protein coupled receptor signaling pathway TAS8587610

    Find genes that share ontologies with GNAI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GNAI2 gene (6 alternative transcripts): 
    NM_001166425.1  NM_001282617.1  NM_001282618.1  NM_001282619.1  NM_001282620.1  NM_002070.3  

    Unigene Cluster for GNAI2:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
    Hs.77269  [show with all ESTs]
    Unigene Representative Sequence: AK126708
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100
    ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)
    ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422
    ENST00000492383 ENST00000266027 ENST00000536647
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2
    Clone
    Products:
         
    OriGene clones in human, mouse for GNAI2 (see all 11)
    OriGene ORF clones in mouse, rat for GNAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
      QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
      QuantiFast Probe-based Assays in human, mouse, rat GNAI2

    Additional mRNA sequence: 

    AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1 
    AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1 

    Selected DOTS entries (see all 42):

    DT.100680604  DT.97768608  DT.75112974  DT.99968212  DT.91784324  DT.97860778  DT.100680607  DT.100057602 
    DT.95357437  DT.97800888  DT.100059846  DT.100862119  DT.91784320  DT.100059845  DT.120873963  DT.100680601 
    DT.95214674  DT.100648169  DT.100680617  DT.120873971  DT.95185336  DT.120874020  DT.100042317  DT.100859294 

    Selected AceView cDNA sequences (see all 1325):

    BQ924802 BM910681 AL522235 BU629898 BE208389 CA393116 BQ052858 BU632644 
    BQ718640 BQ677998 BE257810 CD613961 BM473715 BQ016684 CR610539 AK126708 
    BQ063369 AI863250 BF969380 BQ181203 BQ438820 BE047986 CD367585 BQ680464 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:              -     -     -     -     -     -     -     -                       -                                         -                                 
    SP2:                                            -     -     -     -                 -                                         -                                 
    SP3:              -     -     -     -     -     -     -     -     -                 -                                         -                                 
    SP4:                          -     -     -     -     -     -     -                 -                                         -                                 
    SP5:                                            -     -     -     -     -           -                                         -                                 

    ExUns: 15f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GNAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GNAI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGAA
    GNAI2 Expression
    About this image


    GNAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
     
     Bone (Muscoskeletal System)
             Bone Marrow
    GNAI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77269
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
    QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
    QuantiFast Probe-based Assays in human, mouse, rat GNAI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNAI2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai21 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 91.74(n)1
    98.31(a)1
      9 (58.43 cM)5
    146781  NM_008138.41  NP_032164.21 
     1076141385 
    chicken
    (Gallus gallus)
    Aves GNAI21 guanine nucleotide binding protein (G protein), alpha more 87.32(n)
    95.21(a)
      396367  NM_205402.1  NP_990733.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI26
    guanine nucleotide binding protein (G protein), al...
    91(a)
    1 ↔ 1
    2(148689899-148811953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215122 Xenopus laevis guanine nucleotide-binding protein Gi more 83.72(n)    AF086606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi21e062 wufi21e06 82.55(n)   327650  BC049343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A3 G-protein coupled receptor protein
    signaling pathway more
    76(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA11 GPA1 54.92(n)
    50.14(a)
      856394   NP_011868.1 


    ENSEMBL Gene Tree for GNAI2 (if available)
    TreeFam Gene Tree for GNAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GNAI2 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):
    GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    Find genes that share paralogs with GNAI2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GNAI2
    PGOHUM00000238547 PGOHUM00000239685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GNAI2 (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378532261,2
    Cother150226052(+) GGACCC/G/TGCGTA 6 R G C mis10--------
    rs1491184511,2
    --50204022(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1448643071,2
    --50204071(+) GTCTCC/GATCTC 1 -- us2k10--------
    rs1387130991,2
    --50204100(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1403390471,2
    --50204135(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1454012131,2
    --50204225(+) AACCTC/GCGCCT 1 -- us2k10--------
    rs1924020711,2
    --50204275(+) AGCTGC/GGATTA 1 -- us2k10--------
    rs1474273381,2
    --50204290(+) TGCCCA/GCCACC 1 -- us2k10--------
    rs1483276661,2
    --50204432(+) CAACCA/GTGCCC 1 -- us2k10--------
    rs1154094271,2
    F--50204464(+) TCTAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNAI2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008898CNV Deletion20482838
    dgv5132n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    dgv602n27CNV Loss19166990
    nsv470561CNV Loss18288195
    nsv460531CNV Loss19166990
    nsv523560CNV Loss19592680
    nsv523662CNV Loss19592680
    dgv5131n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): GNAI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 139360   
    OMIM disorders: 192605  
    7 diseases for GNAI2:    
    About MalaCards
    ventricular tachycardia, idiopathic    acth-secreting pituitary adenoma    familial hemiplegic migraine type 1    functioning pituitary adenoma
    olivopontocerebellar atrophy    hemiplegic migraine    familial hemiplegic migraine


    Find genes that share disorders with GNAI2           About GenesLikeMe

    Genetic Association Database (GAD): GNAI2
    Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

    Export disorders for GNAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GNAI2 gene, integrated from 10 sources (see all 143) (see top 10):
    (articles sorted by number of sources associating them with GNAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)1, 2, 3 Didsbury J.R.... Snyderman R. (FEBS Lett. 1987)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)1, 4 Ruggeri R.M....CannavA^ S. (J. Endocrinol. Invest. 2008)
    5. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)1, 2 Lopez-Aranda M.F.... Khan Z.U. (J. Cell Sci. 2007)
    6. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (J. Cell Biol. 2007)
    7. The -318 C&gt;G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)1, 4 Menzaghi C....Trischitta V. (J. Am. Soc. Nephrol. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (Biochem. Biophys. Res. Commun. 2002)
    11. Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PubMed id 1733849)1, 3 Magovcevic I....Morton C.C. (Genomics 1992)
    12. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)1, 2 Itoh H.... Kaziro Y. (J. Biol. Chem. 1988)
    13. Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. (PubMed id 2837412)1, 2 Weinstein L.S.... Carter A.D. (FEBS Lett. 1988)
    14. A small multigene family encodes Gi signal-transduction proteins. (PubMed id 3120178)1, 2 Beals C.R.... Perlmutter R.M. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    15. GI+i2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation. (PubMed id 24298018)1 Minetti G.C....Fornaro M. (Mol. Cell. Biol. 2014)
    16. Ubiquitination of the heterotrimeric G protein I+ subunits GI+i2 and GI+q is prevented by the guanine nucleotide exchange factor Ric-8A. (PubMed id 23665327)1 Chishiki K....Sumimoto H. (Biochem. Biophys. Res. Commun. 2013)
    17. Increased GsI+ within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. (PubMed id 23490066)1 Mooney J.J....Schildkraut J.J. (J Psychiatr Res 2013)
    18. The familial hemiplegic migraine type 1 mutation K1336E affects direct G protein-mediated regulation of neuronal P/Q-type Ca2+ channels. (PubMed id 23430985)1 Garza-LA^pez E....Felix R. (Cephalalgia 2013)
    19. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    20. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    21. The essential role of GiI+2 in prostate cancer cell migration. (PubMed id 22936789)1 Zhong M....Khan S.A. (Mol. Cancer Res. 2012)
    22. Guanine nucleotide-binding protein GI+i2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. (PubMed id 22333621)1 Luissint A.C....Couraud P.O. (J. Cereb. Blood Flow Metab. 2012)
    23. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    24. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    25. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    26. Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-I+ interactions with G protein-I+i and caveolin I. (PubMed id 22230296)1 Watson C.S....Guptarak J. (Steroids 2012)
    27. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    28. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting GI+(i2) for degradation through ubiquitination. (PubMed id 23071112)1 Chandrasekaran P....Venkatesan S. (J. Biol. Chem. 2012)
    29. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    30. A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. (PubMed id 20876399)1 Meixner A....Ueffing M. (amp 2011)
    31. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. (PubMed id 21856938)1 Kremer K.N....Hedin K.E. (J. Immunol. 2011)
    32. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    33. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. (PubMed id 21079996)1 Jiang L....Zhou X. (Hum. Genet. 2011)
    34. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    35. Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway. (PubMed id 21949112)1 Dauphinee S.M....Karsan A. (Am. J. Physiol. Heart Circ. Physiol. 2011)
    36. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    37. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    38. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    39. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    40. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    41. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. (PubMed id 19542234)1 Kuszak A.J....Sunahara R.K. (J. Biol. Chem. 2009)
    42. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    43. GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. (PubMed id 19282110)1 Huang X....Neubig R.R. (Med. Hypotheses 2009)
    44. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    45. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    46. The specific activation of TRPC4 by Gi protein subtype. (PubMed id 18854172)1 Jeon J.P....So I. (Biochem. Biophys. Res. Commun. 2008)
    47. Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. (PubMed id 18940181)1 Quan W....Kim K.M. (Biochem. Biophys. Res. Commun. 2008)
    48. Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. (PubMed id 18453587)1 Cheung R....Collman R.G. (J. Immunol. 2008)
    49. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PubMed id 17255364)1 Lapierre L.A....Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    50. Purification and identification of G protein-coupled receptor protein complexes under native conditions. (PubMed id 17215244)1 Daulat A.M....Jockers R. (amp 2007)
    51. Activation state-dependent interaction between Galphai and p67phox. (PubMed id 16782902)1 Marty C....Ye R.D. (Mol. Cell. Biol. 2006)
    52. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    53. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. (PubMed id 16892066)1 Oldham W.M....Hamm H.E. (amp 2006)
    54. Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. (PubMed id 17139258)1 Damian M....BanA"res J.L. (EMBO J. 2006)
    55. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1 Wang X....Balch W.E. (Cell 2006)
    56. Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors. (PubMed id 16371464)1 Gibson S.K. and Gilman A.G. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    57. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    58. G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). (PubMed id 16298104)1 Willard F.S....Siderovski D.P. (Cell. Signal. 2006)
    59. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    60. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    61. Real-time monitoring of receptor and G-protein interactions in living cells. (PubMed id 15782186)1 GalAcs C....Bouvier M. (Nat. Methods 2005)
    62. HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. (PubMed id 15972662)1 Badr G....Richard Y. (J. Immunol. 2005)
    63. A proteomic snapshot of the human heat shock protein 90 interactome. (PubMed id 16263121)1 Falsone S.F....Kungl A.J. (FEBS Lett. 2005)
    64. Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. (PubMed id 15640523)1 Arinze I.J. and Kawai Y. (J. Biol. Chem. 2005)
    65. Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods. (PubMed id 15047060)1 Bernhard O.K....Sheil M.M. (J. Am. Soc. Mass Spectrom. 2004)
    66. Distribution of C-terminal splice variant of G alpha i2 in rat and monkey brain. (PubMed id 15312896)1 Khan Z.U. and Gutierrez A. (Neuroscience 2004)
    67. CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins. (PubMed id 15251452)1 Mueller A. and Strange P.G. (FEBS Lett. 2004)
    68. Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects. (PubMed id 15331550)1 Richardson M.D....Kwatra M.M. (Diabetes 2004)
    69. Abnormal regulation of G protein alpha(i2) subunit in skin fibroblasts from insulin-resistant hypertensive individuals. (PubMed id 15126921)1 Baritono E....Semplicini A. (J. Hypertens. 2004)
    70. Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization. (PubMed id 14701866)1 Holstein D.M....Saunders C. (J. Biol. Chem. 2004)
    71. Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. (PubMed id 12860983)1 Wakasugi K....Morishima I. (J. Biol. Chem. 2003)
    72. Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness. (PubMed id 14623802)1 Welzig C.M....Galper J.B. (Circulation 2003)
    73. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. (PubMed id 12509430)1 Tall G.G....Gilman A.G. (J. Biol. Chem. 2003)
    74. RGS16 inhibits signalling through the G alpha 13-Rho axis. (PubMed id 14634662)1 Johnson E.N....Druey K.M. (Nat. Cell Biol. 2003)
    75. Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. (PubMed id 12748287)1 Marty C....Ye R.D. (Mol. Cell. Biol. 2003)
    76. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. (PubMed id 12519789)1 Wubbolts R....Stoorvogel W. (J. Biol. Chem. 2003)
    77. Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. (PubMed id 12624107)1 Arinze I.J. and Kawai Y. (J. Biol. Chem. 2003)
    78. Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. (PubMed id 11950062)1 Ozaki H....Kawakami K. (J. Hum. Genet. 2002)
    79. RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13. (PubMed id 12193720)1 Shi G.X....Kehrl J.H. (J. Immunol. 2002)
    80. Cloning and characterization of a novel regulator of G protein signalling in human platelets. (PubMed id 11955952)1 Gagnon A.W.... Leadley R.J. Jr. (Cell. Signal. 2002)
    81. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. (PubMed id 14993377)1 Sunahara R.K. and Taussig R. (Mol. Interv. 2002)
    82. Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently. (PubMed id 12068084)1 Massotte D.... Milligan G. (J. Neurochem. 2002)
    83. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    84. CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. (PubMed id 11168387)1 Mukhopadhyay S. and Howlett A.C. (Eur. J. Biochem. 2001)
    85. Specific involvement of G(alphai2) with epidermal growth factor receptor signaling in rat hepatocytes, and the inhibitory effect of chronic ethanol. (PubMed id 11286993)1 Zhang B.H....Farrell G.C. (Biochem. Pharmacol. 2001)
    86. Stimulation by n6-cyclopentyladenosine of A1 adenosine receptors, coupled to galphai2 protein subunit, has a capacitative effect on human spermatozoa. (PubMed id 11369591)1 Allegrucci C....Minelli A. (Biol. Reprod. 2001)
    87. Identification of the platelet ADP receptor targeted by antithrombotic drugs. (PubMed id 11196645)1 Hollopeter G....Conley P.B. (Nature 2001)
    88. Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway. (PubMed id 12088413)1 Nanki T. and Lipsky P.E. (Cell. Immunol. 2001)
    89. Characterization of RGS5 in regulation of G protein-coupled receptor signaling. (PubMed id 11253162)1 Zhou J....Kimura S. (Life Sci. 2001)
    90. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. (PubMed id 11387333)1 Kimple R.J....Siderovski D.P. (J. Biol. Chem. 2001)
    91. Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth. (PubMed id 11120746)1 Kuemmerle J.F. and Murthy K.S. (J. Biol. Chem. 2001)
    92. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PubMed id 10727522)1 Im D.-S.... Lynch K.R. (Mol. Pharmacol. 2000)
    93. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1). (PubMed id 11118617)1 Caricasole A.... Terstappen G.C. (Biochim. Biophys. Acta 2000)
    94. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. (PubMed id 10906137)1 Fan X.... Manning D.R. (J. Biol. Chem. 2000)
    95. Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. (PubMed id 11055978)1 Hansen J.L....Sheikh S.P. (Circ. Res. 2000)
    96. PAR1 thrombin receptor-G protein interactions. Separation of binding and coupling determinants in the galpha subunit. (PubMed id 10644723)1 Swift S....Kuliopulos A. (J. Biol. Chem. 2000)
    97. Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration. (PubMed id 10840027)1 Cismowski M.J....Duzic E. (J. Biol. Chem. 2000)
    98. Coupling of dopamine receptor subtypes to multiple and diverse G proteins. (PubMed id 10978845)1 Sidhu A. and Niznik H.B. (Int. J. Dev. Neurosci. 2000)
    99. The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2. (PubMed id 10493819)1 KA1hn B. and Gudermann T. (Biochemistry 1999)
    100. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. (PubMed id 10598579)1 Brydon L....Jockers R. (Mol. Endocrinol. 1999)
    101. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. (PubMed id 10471929)1 Cismowski M.J.... Duzic E. (Nat. Biotechnol. 1999)
    102. Association of the proto-oncogene product dbl with G protein betagamma subunits. (PubMed id 10518015)1 Nishida K....Satoh T. (FEBS Lett. 1999)
    103. Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. (PubMed id 9660808)1 Druey K.M....Kehrl J.H. (J. Biol. Chem. 1998)
    104. Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2. (PubMed id 9637720)1 Lerman B.B....Catanzaro D.F. (J. Clin. Invest. 1998)
    105. The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. (PubMed id 9647645)1 Lin P....Farquhar M.G. (J. Cell Biol. 1998)
    106. Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. (PubMed id 9092559)1 Krieger-Brauer H.I....Kather H. (J. Biol. Chem. 1997)
    107. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. (PubMed id 9079700)1 Chen C....Lin S.C. (J. Biol. Chem. 1997)
    108. Physical association of Gi2alpha with interleukin-8 receptors. (PubMed id 8662698)1 Damaj B.B....Naccache P.H. (J. Biol. Chem. 1996)
    109. Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. (PubMed id 8903513)1 Damaj B.B....Naccache P.H. (FASEB J. 1996)
    110. Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells. (PubMed id 8982657)1 Ogino Y....Shimizu N. (Eur. J. Pharmacol. 1996)
    111. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. (PubMed id 8663226)1 Herrlich A....Gudermann T. (J. Biol. Chem. 1996)
    112. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. (PubMed id 8621645)1 Song K.S....Lisanti M.P. (J. Biol. Chem. 1996)
    113. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. (PubMed id 8552586)1 Laugwitz K.L....Schultz G. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    114. Insulin action impaired by deficiency of the G-protein subunit G ialpha2. (PubMed id 8587610)1 Moxham C.M. and Malbon C.C. (Nature 1996)
    115. Identification and subcellular distribution of the Gi-proteins in the enterocytic-differentiated adenocarcinoma cell-line, Caco-2. (PubMed id 9237368)1 Lacombe C....Paris H. (Biol. Cell 1996)
    116. The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. (PubMed id 8663053)1 Zhang J. and Pratt R.E. (J. Biol. Chem. 1996)
    117. Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton. (PubMed id 8663057)1 SAorndahl E....Andersson T. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2771 HGNC: 4385 AceView: GNAI2 Ensembl:ENSG00000114353 euGenes: HUgn2771
    ECgene: GNAI2 Kegg: 2771 H-InvDB: GNAI2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GNAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GNAI2 gene:
    Search GeneIP for patents involving GNAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of GNAI2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GNAI2   OriGene RNAi products in human, mouse, rat for GNAI2  
     OriGene qPCR primer pairs and template standards for GNAI2   OriGene Protein Over-expression Lysate for GNAI2  
     OriGene MassSpec for GNAI2   OriGene clones in human, mouse for GNAI2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2   OriGene Purified Protein for GNAI2  
     OriGene ORF clones in mouse, rat for GNAI2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNAI2   OriGene Custom Protein Services for GNAI2  

     
     
     Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GNAI2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAI2 Predesigned siRNA for gene silencing in human, mouse, rat GNAI2
     QuantiFast Probe-based Assays in human, mouse, rat GNAI2 QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
     PCR Arrays including human, mouse, rat GNAI2 Search Chromatin IP Primers for GNAI2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2  GeneGlobe Interaction Network for GNAI2
     Regulatory tfbs in GNAI2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GNAI2 GenScript cDNA clones with any tag delivered in your preferred vector for GNAI2
     GenScript Custom Assay Services for GNAI2 GenScript Custom overexpressing Cell Line Services for GNAI2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GNAI2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GNAI2 antibodies
     GNAI2 proteins
     GNAI2 lysates
     Antibodies for GNAI2
     See all of Abcam's Antibodies, Kits and Proteins for GNAI2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GNAI2
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GNAI2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2
     SwitchGear 3'UTR luciferase reporter plasmids for GNAI2
     SwitchGear Promoter luciferase reporter plasmids for GNAI2
     ThermoFisher Antibody for GNAI2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
     Browse compounds at ApexBio
     Search Addgene for plasmids for GNAI2
      Search eBioscience for proteins for GNAI2
      Search eBioscience for elisas for GNAI2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GNAI2
     antibodies-online antibodies for GNAI2 (39 products)
     antibodies-online kits for GNAI2 (11 products)
     antibodies-online peptides for GNAI2
     antibodies-online proteins for GNAI2 (12 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNAI2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4