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Aliases for GNAI2 Gene

Aliases for GNAI2 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2 2 3
  • GNAI2B 3 4 6
  • GTP-Binding Regulatory Protein Gi Alpha-2 Chain 2 3
  • Adenylate Cyclase-Inhibiting G Alpha Protein 3 4
  • GIP 3 6
  • Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit 3
  • Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-2 3
  • H_LUCA15.1 3
  • H_LUCA16.1 3

External Ids for GNAI2 Gene

Previous HGNC Symbols for GNAI2 Gene

  • GNAI2B

Previous GeneCards Identifiers for GNAI2 Gene

  • GC03M049690
  • GC03M049860
  • GC03P050118
  • GC03P050223
  • GC03P050232
  • GC03P050239
  • GC03P050263

Summaries for GNAI2 Gene

Entrez Gene Summary for GNAI2 Gene

  • The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GNAI2 Gene

GNAI2 (Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2) is a Protein Coding gene. Diseases associated with GNAI2 include pituitary adenoma, acth-secreting and ventricular tachycardia, idiopathic. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAI2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division

  • Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool

Tocris Summary for GNAI2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAI2 Gene

Genomics for GNAI2 Gene

Regulatory Elements for GNAI2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNAI2 Gene

Start:
50,226,292 bp from pter
End:
50,259,355 bp from pter
Size:
33,064 bases
Orientation:
Plus strand

Genomic View for GNAI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAI2 Gene

Proteins for GNAI2 Gene

  • Protein details for GNAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04899-GNAI2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(i) subunit alpha-2
    Protein Accession:
    P04899
    Secondary Accessions:
    • B3KTZ0
    • B4DYA0
    • B4E2X5
    • Q6B6N3
    • Q8IZ71

    Protein attributes for GNAI2 Gene

    Size:
    355 amino acids
    Molecular mass:
    40451 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B.

    Alternative splice isoforms for GNAI2 Gene

neXtProt entry for GNAI2 Gene

Proteomics data for GNAI2 Gene at MOPED

Post-translational modifications for GNAI2 Gene

  • Ubiquitination at Lys35, Lys46, Lys193, Lys198, Lys249, Lys296, Lys307, and Lys350
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GNAI2 Gene

Domains for GNAI2 Gene

Graphical View of Domain Structure for InterPro Entry

P04899

UniProtKB/Swiss-Prot:

GNAI2_HUMAN :
  • P04899
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAI2: view

No data available for Gene Families for GNAI2 Gene

Function for GNAI2 Gene

Molecular function for GNAI2 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
UniProtKB/Swiss-Prot Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool

Gene Ontology (GO) - Molecular Function for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GNAI2: view
genes like me logo Genes that share phenotypes with GNAI2: view

Animal Models for GNAI2 Gene

MGI Knock Outs for GNAI2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAI2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNAI2 Gene

Localization for GNAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAI2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAI2 Gene COMPARTMENTS Subcellular localization image for GNAI2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 17635935
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with GNAI2: view

Pathways for GNAI2 Gene

genes like me logo Genes that share pathways with GNAI2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001973 adenosine receptor signaling pathway IBA --
GO:0006184 obsolete GTP catabolic process --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS 7961880
genes like me logo Genes that share ontologies with GNAI2: view

Compounds for GNAI2 Gene

(5) Tocris Compounds for GNAI2 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNAI2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNAI2: view

Transcripts for GNAI2 Gene

Unigene Clusters for GNAI2 Gene

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAI2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - - - - -
SP10: - - - -
SP11:
SP12:

ExUns: 15f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for GNAI2 Gene

GeneLoc Exon Structure for
GNAI2
ECgene alternative splicing isoforms for
GNAI2

Expression for GNAI2 Gene

mRNA expression in normal human tissues for GNAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNAI2 Gene

This gene is overexpressed in Whole Blood (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAI2 Gene

SOURCE GeneReport for Unigene cluster for GNAI2 Gene Hs.77269

genes like me logo Genes that share expressions with GNAI2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNAI2 Gene

Orthologs for GNAI2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNAI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAI2 35
  • 99.25 (n)
  • 100 (a)
GNAI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAI2 35
  • 93.52 (n)
  • 99.44 (a)
GNAI2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAI2 35
  • 93.71 (n)
  • 98.59 (a)
GNAI2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai2 35
  • 91.74 (n)
  • 98.31 (a)
Gnai2 16
Gnai2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnai2 35
  • 92.49 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves GNAI2 35
  • 87.32 (n)
  • 95.21 (a)
GNAI2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAI2 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21512 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gnai2 35
  • 80.19 (n)
  • 94.37 (a)
MGC76300 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11223 35
zebrafish
(Danio rerio)
Actinopterygii gnai2a 36
  • 87 (a)
OneToMany
gnai2b 35
  • 80.5 (n)
  • 92.22 (a)
gnai2b 36
  • 92 (a)
OneToMany
wufi21e06 35
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 77 (a)
OneToMany
Galpha73B 37
  • 35 (a)
G-ialpha65A 37
  • 76 (a)
G-oalpha47A 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea odr-3 37
  • 49 (a)
gpa-14 37
  • 32 (a)
gpa-6 37
  • 37 (a)
gpa-4 37
  • 61 (a)
goa-1 37
  • 68 (a)
gpa-10 37
  • 34 (a)
gpa-15 37
  • 43 (a)
gpa-8 37
  • 39 (a)
gpa-3 37
  • 51 (a)
gpa-9 37
  • 39 (a)
gpa-1 37
  • 45 (a)
gpa-7 37
  • 54 (a)
gpa-11 37
  • 40 (a)
gpa-2 37
  • 45 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR153C 35
  • 60.48 (n)
  • 49.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA1 35
  • 54.92 (n)
  • 50.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25916g 35
  • 50.87 (n)
  • 47.4 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06493 35
  • 60.8 (n)
  • 55.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 36
  • 80 (a)
OneToMany
Species with no ortholog for GNAI2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAI2 Gene

ENSEMBL:
Gene Tree for GNAI2 (if available)
TreeFam:
Gene Tree for GNAI2 (if available)

Paralogs for GNAI2 Gene

Paralogs for GNAI2 Gene

Pseudogenes.org Pseudogenes for GNAI2 Gene

genes like me logo Genes that share paralogs with GNAI2: view

Variants for GNAI2 Gene

Sequence variations from dbSNP and Humsavar for GNAI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12813 -- 50,258,640(+) GGAGG(G/T)GGGCA utr-variant-3-prime
rs12895 -- 50,259,042(-) CAGCA(A/G)AGGGA utr-variant-3-prime
rs15488 -- 50,259,294(-) CATGT(A/C/G/T)AAAAA utr-variant-3-prime
rs762707 -- 50,252,421(-) TCCTC(A/C/G/T)GAGTA synonymous-codon, reference, utr-variant-5-prime
rs916025 -- 50,239,810(-) CAGTG(C/T)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNAI2 Gene

Variant ID Type Subtype PubMed ID
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680
nsv876768 CNV Gain 21882294
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv602n27 CNV Loss 19166990
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
esv1008898 CNV Deletion 20482838

Relevant External Links for GNAI2 Gene

HapMap Linkage Disequilibrium report
GNAI2
Human Gene Mutation Database (HGMD)
GNAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNAI2 Gene

Disorders for GNAI2 Gene

(1) OMIM Diseases for GNAI2 Gene (139360)

Relevant External Links for GNAI2

Genetic Association Database (GAD)
GNAI2
Human Genome Epidemiology (HuGE) Navigator
GNAI2
genes like me logo Genes that share disorders with GNAI2: view

No data available for UniProtKB/Swiss-Prot for GNAI2 Gene

Publications for GNAI2 Gene

  1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PMID: 3100330) Didsbury J.R. … Snyderman R. (FEBS Lett. 1987) 2 3 4
  2. A small multigene family encodes Gi signal-transduction proteins. (PMID: 3120178) Beals C.R. … Perlmutter R.M. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  3. Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PMID: 1733849) Magovcevic I. … Morton C.C. (Genomics 1992) 2 3
  4. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PMID: 12359238) Komatsuzaki K. … Kinane T.B. (Biochem. Biophys. Res. Commun. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GNAI2 Gene

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