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Aliases for GNAI2 Gene

Aliases for GNAI2 Gene

  • G Protein Subunit Alpha I2 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2 2 3 5
  • GTP-Binding Regulatory Protein Gi Alpha-2 Chain 2 3
  • Adenylate Cyclase-Inhibiting G Alpha Protein 3 4
  • GNAI2B 3 4
  • Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit 3
  • H_LUCA15.1 3
  • H_LUCA16.1 3
  • GIP 3

External Ids for GNAI2 Gene

Previous HGNC Symbols for GNAI2 Gene

  • GNAI2B

Previous GeneCards Identifiers for GNAI2 Gene

  • GC03M049690
  • GC03M049860
  • GC03P050118
  • GC03P050223
  • GC03P050232
  • GC03P050239
  • GC03P050263

Summaries for GNAI2 Gene

Entrez Gene Summary for GNAI2 Gene

  • The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GNAI2 Gene

GNAI2 (G Protein Subunit Alpha I2) is a Protein Coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic and pituitary adenoma, acth-secreting. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAI2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

  • Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.

Tocris Summary for GNAI2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNAI2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAI2 Gene

Genomics for GNAI2 Gene

Regulatory Elements for GNAI2 Gene

Promoters for GNAI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNAI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNAI2 Gene

Chromosome:
3
Start:
50,226,292 bp from pter
End:
50,259,355 bp from pter
Size:
33,064 bases
Orientation:
Plus strand

Genomic View for GNAI2 Gene

Genes around GNAI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNAI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAI2 Gene

Proteins for GNAI2 Gene

  • Protein details for GNAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04899-GNAI2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(i) subunit alpha-2
    Protein Accession:
    P04899
    Secondary Accessions:
    • B3KTZ0
    • B4DYA0
    • B4E2X5
    • Q6B6N3
    • Q8IZ71

    Protein attributes for GNAI2 Gene

    Size:
    355 amino acids
    Molecular mass:
    40451 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B.

    Alternative splice isoforms for GNAI2 Gene

neXtProt entry for GNAI2 Gene

Proteomics data for GNAI2 Gene at MOPED

Post-translational modifications for GNAI2 Gene

  • (Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
  • Ubiquitination at Lys 296 and Lys 307
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GNAI2 Gene

Domains & Families for GNAI2 Gene

Graphical View of Domain Structure for InterPro Entry

P04899

UniProtKB/Swiss-Prot:

GNAI2_HUMAN :
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAI2: view

No data available for Gene Families for GNAI2 Gene

Function for GNAI2 Gene

Molecular function for GNAI2 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
UniProtKB/Swiss-Prot Function:
Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.

Gene Ontology (GO) - Molecular Function for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0031683 G-protein beta/gamma-subunit complex binding IEA,IBA --
genes like me logo Genes that share ontologies with GNAI2: view
genes like me logo Genes that share phenotypes with GNAI2: view

Human Phenotype Ontology for GNAI2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GNAI2 Gene

MGI Knock Outs for GNAI2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GNAI2 Gene

Localization for GNAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAI2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAI2 Gene COMPARTMENTS Subcellular localization image for GNAI2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 17635935
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0030425 dendrite IEA --
GO:0030496 midbody IDA 17635935
genes like me logo Genes that share ontologies with GNAI2: view

Pathways & Interactions for GNAI2 Gene

genes like me logo Genes that share pathways with GNAI2: view

SIGNOR curated interactions for GNAI2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006457 protein folding TAS --
GO:0007165 signal transduction IEA,TAS 7961880
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 8587610
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNAI2: view

Drugs & Compounds for GNAI2 Gene

(3) Drugs for GNAI2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNAI2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4
genes like me logo Genes that share compounds with GNAI2: view

Transcripts for GNAI2 Gene

Unigene Clusters for GNAI2 Gene

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - - - - -
SP10: - - - -
SP11:
SP12:

ExUns: 15f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for GNAI2 Gene

GeneLoc Exon Structure for
GNAI2
ECgene alternative splicing isoforms for
GNAI2

Expression for GNAI2 Gene

mRNA expression in normal human tissues for GNAI2 Gene

mRNA differential expression in normal tissues according to GTEx for GNAI2 Gene

This gene is overexpressed in Whole Blood (x8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAI2 Gene



SOURCE GeneReport for Unigene cluster for GNAI2 Gene Hs.77269

genes like me logo Genes that share expression patterns with GNAI2: view

Protein tissue co-expression partners for GNAI2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAI2 Gene

Orthologs for GNAI2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNAI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAI2 35
  • 99.25 (n)
  • 100 (a)
GNAI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAI2 36
  • 99 (a)
OneToOne
GNAI2 35
  • 93.52 (n)
  • 99.44 (a)
dog
(Canis familiaris)
Mammalia GNAI2 35
  • 93.71 (n)
  • 98.59 (a)
GNAI2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai2 16
Gnai2 35
  • 91.74 (n)
  • 98.31 (a)
Gnai2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnai2 35
  • 92.49 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves GNAI2 36
  • 95 (a)
OneToOne
GNAI2 35
  • 87.32 (n)
  • 95.21 (a)
lizard
(Anolis carolinensis)
Reptilia GNAI2 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21512 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gnai2 35
  • 80.19 (n)
  • 94.37 (a)
MGC76300 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11223 35
zebrafish
(Danio rerio)
Actinopterygii gnai2b 35
  • 80.5 (n)
  • 92.22 (a)
wufi21e06 35
gnai2a 36
  • 87 (a)
OneToMany
gnai2b 36
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 77 (a)
OneToMany
G-ialpha65A 37
  • 76 (a)
G-oalpha47A 37
  • 67 (a)
Galpha73B 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea goa-1 37
  • 68 (a)
gpa-1 37
  • 45 (a)
gpa-10 37
  • 34 (a)
gpa-11 37
  • 40 (a)
gpa-14 37
  • 32 (a)
gpa-15 37
  • 43 (a)
gpa-2 37
  • 45 (a)
gpa-3 37
  • 51 (a)
gpa-4 37
  • 61 (a)
gpa-6 37
  • 37 (a)
gpa-7 37
  • 54 (a)
gpa-8 37
  • 39 (a)
gpa-9 37
  • 39 (a)
odr-3 37
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR153C 35
  • 60.48 (n)
  • 49.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA1 35
  • 54.92 (n)
  • 50.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25916g 35
  • 50.87 (n)
  • 47.4 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06493 35
  • 60.8 (n)
  • 55.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 36
  • 80 (a)
OneToMany
Species with no ortholog for GNAI2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAI2 Gene

ENSEMBL:
Gene Tree for GNAI2 (if available)
TreeFam:
Gene Tree for GNAI2 (if available)

Paralogs for GNAI2 Gene

Paralogs for GNAI2 Gene

Pseudogenes.org Pseudogenes for GNAI2 Gene

genes like me logo Genes that share paralogs with GNAI2: view

Variants for GNAI2 Gene

Sequence variations from dbSNP and Humsavar for GNAI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12895 -- 50,259,042(-) CAGCA(A/G)AGGGA utr-variant-3-prime
rs1050067 -- 50,252,502(+) ATGGG(A/C)AACCT reference, synonymous-codon
rs2298953 -- 50,249,828(+) AGGCC(A/G/T)TTCCC intron-variant
rs2298954 -- 50,250,119(+) CTTCA(C/T)TGGTT intron-variant
rs1894324 -- 50,243,449(-) CATCT(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNAI2 Gene

Variant ID Type Subtype PubMed ID
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680
nsv876768 CNV Gain 21882294
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv602n27 CNV Loss 19166990
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
esv1008898 CNV Deletion 20482838

Variation tolerance for GNAI2 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNAI2 Gene

HapMap Linkage Disequilibrium report
GNAI2
Human Gene Mutation Database (HGMD)
GNAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNAI2 Gene

Disorders for GNAI2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GNAI2 Gene - From: OMIM, ClinVar, GeneTests, and GeneCards

Disorder Aliases PubMed IDs
ventricular tachycardia, idiopathic
  • familial ventricular tachycardia
pituitary adenoma, acth-secreting
  • acth-secreting pituitary adenoma
olivopontocerebellar atrophy
  • spinocerebellar ataxia type 2
familial hemiplegic migraine
  • migraine, familial hemiplegic
hemiplegic migraine
  • migraine hemiplegic
- elite association - COSMIC cancer census association via MalaCards
Search GNAI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNAI2

Genetic Association Database (GAD)
GNAI2
Human Genome Epidemiology (HuGE) Navigator
GNAI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNAI2
genes like me logo Genes that share disorders with GNAI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNAI2 Gene

Publications for GNAI2 Gene

  1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PMID: 3100330) Didsbury J.R. … Snyderman R. (FEBS Lett. 1987) 2 3 4 67
  2. Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PMID: 1733849) Magovcevic I. … Morton C.C. (Genomics 1992) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with GI+i in TRPC4 activation process. (PMID: 25788576) Myeong J. … So I. (Am. J. Physiol., Cell Physiol. 2015) 3

Products for GNAI2 Gene

Sources for GNAI2 Gene

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