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GNAI2 Gene

protein-coding   GIFtS: 69
GCID: GC03P050263

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...


(Previous symbol: GNAI2B)
  See GNAI2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 21 2
     H_LUCA15.12
GNAI2B1 2 3 5     H_LUCA16.12
GTP-Binding Regulatory Protein Gi Alpha-2 Chain1 2     Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-22
Adenylate Cyclase-Inhibiting G Alpha Protein2 3     Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit2
GIP2 5     

External Ids:    HGNC: 43851   Entrez Gene: 27712   Ensembl: ENSG000001143537   OMIM: 1393605   UniProtKB: P048993   

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNAI2 Gene:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The
encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of
adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for GNAI2 Gene:
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) is a protein-coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic, and acth-secreting pituitary adenoma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
intracellular pool

summary for GNAI2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAI2 gene promoter:
         SRF   CHOP-10   GR   Sp1   SRF (504 AA)   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI2 promoter sequence
   Search Chromatin IP Primers for GNAI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Start:
50,263,724 bp from pter      End:
50,296,787 bp from pter
Size:
33,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2  
Size: 355 amino acids; 40451 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with
UNC5B
Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71
Alternative splicing: 4 isoforms:  P04899-1   P04899-2   P04899-3   P04899-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Explore proteomics data for GNAI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys46, Lys193, Lys198, Lys249, Lys296, Lys307, Lys350
  • Modification sites at PhosphoSitePlus

  • See GNAI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1  

    ENSEMBL proteins: 
     ENSP00000406871   ENSP00000406065   ENSP00000312999   ENSP00000394321   ENSP00000395736  
     ENSP00000406369   ENSP00000266027   ENSP00000444360  
    Reactome Protein details: P04899

    GNAI2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GNAI2
    OriGene Protein Over-expression Lysate for GNAI2
    OriGene MassSpec for GNAI2
    OriGene Custom Protein Services for GNAI2
    GenScript Custom Purified and Recombinant Proteins Services for GNAI2
    Novus Biologicals GNAI2 Proteins
    Novus Biologicals GNAI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GNAI2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNAI2 

    GNAI2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
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    OriGene Custom Antibody Services for GNAI2
    Novus Biologicals GNAI2 Antibodies
    Abcam antibodies for GNAI2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GNAI2
    LSBio Antibodies in human, mouse, rat for GNAI2

    GNAI2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of GNAI2
    OriGene Custom Assay Services for GNAI2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNAI2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GNAI2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P04899

    ProtoNet protein and cluster: P04899

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Find genes that share domains with GNAI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
    Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
    intracellular pool

         Genatlas biochemistry entry for GNAI2:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with GNAI2           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gnai2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with GNAI2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GNAI2: Gnai2tm1Lbi Gnai2tm1Rmm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNAI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNAI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNAI2:
    hsa-mir-30e-5p (MIRT044144), hsa-mir-1 (MIRT023620), hsa-mir-935 (MIRT036699), hsa-mir-30a-5p (MIRT005181), hsa-mir-30d-5p (MIRT003274), hsa-mir-124-3p (MIRT022392), hsa-mir-148b-3p (MIRT043588), hsa-mir-92b-3p (MIRT040616), hsa-mir-877-3p (MIRT036851)

    Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNAI2

    Clone
    Products:
         
    OriGene clones in human, mouse for GNAI2 (see all 11)
    OriGene ORF clones in mouse, rat for GNAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNAI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GNAI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNAI2_HUMAN, P04899: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell
    membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow
    and/or the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17635935
    GO:0005829cytosol IEA--

    Find genes that share ontologies with GNAI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNAI2 About   (see all 83)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 120.74
    G alpha (z) signalling events0.47
    G-protein activation0.74
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    4Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    5G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44


    Find genes that share SuperPaths with GNAI2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNAI2 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for GNAI2 (see all 14)
        Signal Transduction of S1P Receptor
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone
    TSH signaling pathway

    Selected Reactome Pathways for GNAI2 (see all 9)
        Regulation of insulin secretion
    G alpha (z) signalling events
    G-protein activation
    Adenylate cyclase inhibitory pathway
    PLC beta mediated events

    3 PharmGKB Pathways for GNAI2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNAI2) (see all 27):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Adrenergic signaling in cardiomyocytes
    Axon guidance
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAI2 (P048991, 2, 3 ENSP000003129994) via UniProtKB, MINT, STRING, and/or I2D (see all 390) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145981, 2, 3, ENSP000002894734EBI-353997,EBI-395044 MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
    GNB1P628732, 3, ENSP000003678724MINT-7135221 I2D: score=1 STRING: ENSP00000367872
    HSP90AB1P082382, 3MINT-72645 I2D: score=3 
    NCF2P198781, 2, 3, ENSP000003565054EBI-353997,EBI-489611 MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
    CXCR5P323022, 3, ENSP000002921744MINT-50704 MINT-50707 I2D: score=1 STRING: ENSP00000292174
    MDFIQ997501, 2, 3, ENSP000002303214EBI-353997,EBI-724076 MINT-66321 I2D: score=6 STRING: ENSP00000230321
    MAP3K3Q997592, 3, ENSP000003549274MINT-48437 I2D: score=2 STRING: ENSP00000354927
    PLSCR1O151622, 3, ENSP000003454944MINT-66701 I2D: score=5 STRING: ENSP00000345494
    CNR1P215543, ENSP000003585114I2D: score=3 STRING: ENSP00000358511
    MAPK1P284823, ENSP000002158324I2D: score=3 STRING: ENSP00000215832
    NUCB1Q028183, ENSP000002632734I2D: score=3 STRING: ENSP00000263273
    RGS12O149243, ENSP000003393814I2D: score=3 STRING: ENSP00000339381
    RGS16O154923, ENSP000003565294I2D: score=3 STRING: ENSP00000356529
    ADORA1P305423, ENSP000003085494I2D: score=2 STRING: ENSP00000308549
    C5AR1P217303, ENSP000003471974I2D: score=2 STRING: ENSP00000347197
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    IGF1RP080693, ENSP000002680354I2D: score=2 STRING: ENSP00000268035
    LHBP012293, ENSP000002214214I2D: score=2 STRING: ENSP00000221421
    OPRD1P411433, ENSP000002349614I2D: score=2 STRING: ENSP00000234961
    PIK3C3Q8NEB93, ENSP000002620394I2D: score=2 STRING: ENSP00000262039
    PIK3R4Q995703, ENSP000003492054I2D: score=2 STRING: ENSP00000349205
    RGS18Q9NS283, ENSP000003564304I2D: score=2 STRING: ENSP00000356430
    RIC8AQ9NPQ83, ENSP000003259414I2D: score=2 STRING: ENSP00000325941
    TUBA4AP683663, ENSP000002484374I2D: score=2 STRING: ENSP00000248437
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    ADCY1Q088283, ENSP000002973234I2D: score=1 STRING: ENSP00000297323
    ADRA2AP089133, ENSP000002801554I2D: score=1 STRING: ENSP00000280155
    ADRA2BP180893, ENSP000003872814I2D: score=1 STRING: ENSP00000387281
    AGTR2P500523, ENSP000003609734I2D: score=1 STRING: ENSP00000360973
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    EYA2O001673, ENSP000003336404I2D: score=1 STRING: ENSP00000333640
    F2RP251163, ENSP000003213264I2D: score=1 STRING: ENSP00000321326
    FGRP097693, ENSP000003631154I2D: score=1 STRING: ENSP00000363115
    FPR1P214623, ENSP000003027074I2D: score=1 STRING: ENSP00000302707
    HCKP086313, ENSP000003650124I2D: score=1 STRING: ENSP00000365012
    LHCGRP228883, ENSP000002949544I2D: score=1 STRING: ENSP00000294954
    LPAR3Q9UBY53, ENSP000003596434I2D: score=1 STRING: ENSP00000359643
    OPRM1P353723, ENSP000003946244I2D: score=1 STRING: ENSP00000394624
    PTPRUQ927293, ENSP000003349414I2D: score=1 STRING: ENSP00000334941
    RGS4P497983, ENSP000003971814I2D: score=1 STRING: ENSP00000397181
    TSHRP164733, ENSP000002981714I2D: score=1 STRING: ENSP00000298171
    GPSM2P812743, ENSP000002641264I2D: score=3 STRING: ENSP00000264126
    PTGER3P431153, ENSP000003490034I2D: score=1 STRING: ENSP00000349003
    CXCR1P250243, ENSP000002956834I2D: score=4 STRING: ENSP00000295683
    RGS19P497953, ENSP000003331944I2D: score=4 STRING: ENSP00000333194
    RGS5O155393, ENSP000003193084I2D: score=2 STRING: ENSP00000319308
    GNB5O147753, ENSP000002618374I2D: score=7 STRING: ENSP00000261837
    MTNR1AP480393, ENSP000003028114I2D: score=3 STRING: ENSP00000302811
    CAV1Q031353, ENSP000003391914I2D: score=2 STRING: ENSP00000339191
    CHRM1P112293, ENSP000003064904I2D: score=1 STRING: ENSP00000306490
    DRD2P144163, ENSP000003548594I2D: score=2 STRING: ENSP00000354859
    EDNRAP251013, ENSP000003150114I2D: score=1 STRING: ENSP00000315011
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    EYA1Q995023, ENSP000003426264I2D: score=1 STRING: ENSP00000342626
    IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
    P2RY12Q9H2443, ENSP000003072594I2D: score=1 STRING: ENSP00000307259
    RASD1Q9Y2723, ENSP000002256884I2D: score=1 STRING: ENSP00000225688
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    RGS14O435663, ENSP000003862294I2D: score=3 STRING: ENSP00000386229
    NGBQ9NPG23, ENSP000002983524I2D: score=1 STRING: ENSP00000298352
    TTC1Q996143, ENSP000002312384I2D: score=4 STRING: ENSP00000231238
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    GNAI1P630963, ENSP000003430274I2D: score=3 STRING: ENSP00000343027
    MTNR1BP492863, ENSP000002570684I2D: score=2 STRING: ENSP00000257068
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    HDLBPQ003413, ENSP000003120424I2D: score=5 STRING: ENSP00000312042
    LRRK2Q5S0073, ENSP000002989104I2D: score=1 STRING: ENSP00000298910
    ASNA1O436813, ENSP000003498874I2D: score=6 STRING: ENSP00000349887
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    ACTR2P611603I2D: score=1 
    AHSA1O954333I2D: score=1 
    ATICP319393I2D: score=1 
    CCT2P783713I2D: score=1 
    CCT3P493683I2D: score=1 
    CCT5P486433I2D: score=1 
    CCT6AP402273I2D: score=1 
    CHMP4AQ9BY433I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    DLG4P783523I2D: score=1 
    DNAJA1P316893I2D: score=1 
    EIF2S3P410913I2D: score=1 
    FBXW7Q969H03I2D: score=1 
    FNTBP493563I2D: score=1 
    HAX1O001653I2D: score=1 
    IDH3GP515533I2D: score=1 
    KIFC3Q9BVG83I2D: score=1 
    NKD1Q969G93I2D: score=1 
    PMM2O153053I2D: score=1 
    PSMD1Q994603I2D: score=1 
    SLC2A4P146723I2D: score=1 
    TCP1P179873I2D: score=1 
    USP4Q131073I2D: score=1 
    XPR1Q9UBH63I2D: score=1 
    YWHABP319463I2D: score=1 
    YWHAZP631043I2D: score=1 
    ZDHHC17Q8IUH53I2D: score=1 
    NCF4Q150802MINT-7135281
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADCY9ENSP000002940164STRING: ENSP00000294016
    AKT1ENSP000002702024STRING: ENSP00000270202
    ANXA1ENSP000002574974STRING: ENSP00000257497
    BCAR1ENSP000001623304STRING: ENSP00000162330
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    BLKENSP000002590894STRING: ENSP00000259089
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR7ENSP000002466574STRING: ENSP00000246657
    CD3GENSP000002921444STRING: ENSP00000292144
    CDC42ENSP000003144584STRING: ENSP00000314458
    CXCL12ENSP000003635484STRING: ENSP00000363548
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR3ENSP000003627954STRING: ENSP00000362795
    CXCR4ENSP000003868844STRING: ENSP00000386884
    DOCK2ENSP000002569354STRING: ENSP00000256935
    DRD3ENSP000003731694STRING: ENSP00000373169
    EDN1ENSP000003686834STRING: ENSP00000368683
    EDNRBENSP000003353114STRING: ENSP00000335311
    ESR1ENSP000002062494STRING: ENSP00000206249
    FYNENSP000003576564STRING: ENSP00000357656
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR3ENSP000002490414STRING: ENSP00000249041
    GNA14ENSP000003658074STRING: ENSP00000365807
    GNA15ENSP000002629584STRING: ENSP00000262958
    GNALENSP000003340514STRING: ENSP00000334051
    GNAO1ENSP000002624934STRING: ENSP00000262493
    GNASENSP000003601414STRING: ENSP00000360141
    GNAT1ENSP000002324614STRING: ENSP00000232461
    GNAT2ENSP000002513374STRING: ENSP00000251337
    GNAT3ENSP000003813394STRING: ENSP00000381339
    GNAZENSP000002489964STRING: ENSP00000248996
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR18ENSP000003434284STRING: ENSP00000343428
    HRH3ENSP000003425604STRING: ENSP00000342560
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPYENSP000002421524STRING: ENSP00000242152
    OPRK1ENSP000002655724STRING: ENSP00000265572
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PDE1AENSP000003315744STRING: ENSP00000331574
    PDE3AENSP000003519574STRING: ENSP00000351957
    PDE3BENSP000002820964STRING: ENSP00000282096
    PDE4AENSP000002704744STRING: ENSP00000270474
    PDE4CENSP000003476894STRING: ENSP00000347689
    PDE4DENSP000003848064STRING: ENSP00000384806
    PDE7AENSP000003687304STRING: ENSP00000368730
    PDE7BENSP000003106614STRING: ENSP00000310661
    PDYNENSP000002173054STRING: ENSP00000217305
    PENKENSP000003242484STRING: ENSP00000324248
    PLCB1ENSP000003381854STRING: ENSP00000338185
    PLCB3ENSP000002792304STRING: ENSP00000279230
    POMCENSP000002647084STRING: ENSP00000264708
    PPYENSP000002259924STRING: ENSP00000225992
    PYYENSP000003531984STRING: ENSP00000353198
    RGS1ENSP000003564294STRING: ENSP00000356429
    RGS10ENSP000003580994STRING: ENSP00000358099
    RGS6ENSP000003839534STRING: ENSP00000383953
    RGS7ENSP000003555204STRING: ENSP00000355520
    RXFP3ENSP000003287084STRING: ENSP00000328708
    RXFP4ENSP000003573014STRING: ENSP00000357301
    S1PR1ENSP000003054164STRING: ENSP00000305416
    SRCENSP000003509414STRING: ENSP00000350941
    SSTENSP000002876414STRING: ENSP00000287641
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR5ENSP000002938974STRING: ENSP00000293897
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2CENSP000003860694STRING: ENSP00000386069
    AKT3ENSP000002638264STRING: ENSP00000263826
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    C3ENSP000002459074STRING: ENSP00000245907
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5ENSP000002236424STRING: ENSP00000223642
    CASRENSP000002961544STRING: ENSP00000296154
    CCL11ENSP000003022344STRING: ENSP00000302234
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR8ENSP000003264324STRING: ENSP00000326432
    CD247ENSP000003547824STRING: ENSP00000354782
    CD3DENSP000003006924STRING: ENSP00000300692
    CD3EENSP000003545664STRING: ENSP00000354566
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCR6ENSP000003044144STRING: ENSP00000304414
    DRD4ENSP000001761834STRING: ENSP00000176183
    ELMO1ENSP000003121854STRING: ENSP00000312185
    FPR2ENSP000003401914STRING: ENSP00000340191
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALR2ENSP000003296844STRING: ENSP00000329684
    GLI1ENSP000002286824STRING: ENSP00000228682
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR55ENSP000003758934STRING: ENSP00000375893
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HLA-DRB1ENSP000003530994STRING: ENSP00000353099
    HRH4ENSP000002569064STRING: ENSP00000256906
    ITPR3ENSP000003634354STRING: ENSP00000363435
    KNG1ENSP000002650234STRING: ENSP00000265023
    LCKENSP000003378254STRING: ENSP00000337825
    LPAR2ENSP000003846654STRING: ENSP00000384665
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY14ENSP000003083614STRING: ENSP00000308361
    PDE11AENSP000002860634STRING: ENSP00000286063
    PDE1BENSP000002430524STRING: ENSP00000243052
    PDE2AENSP000003349104STRING: ENSP00000334910
    PDE4BENSP000003321164STRING: ENSP00000332116
    PF4ENSP000002960294STRING: ENSP00000296029
    PLCB2ENSP000002604024STRING: ENSP00000260402
    PLCB4ENSP000003341054STRING: ENSP00000334105
    PLCG1ENSP000002440074STRING: ENSP00000244007
    PMCHENSP000003322254STRING: ENSP00000332225
    PNOCENSP000003019084STRING: ENSP00000301908
    POLR3CENSP000003345644STRING: ENSP00000334564
    PPBPENSP000002960284STRING: ENSP00000296028
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    RAC1ENSP000003484614STRING: ENSP00000348461
    RAPGEF3ENSP000003957084STRING: ENSP00000395708
    RAPGEF4ENSP000003802714STRING: ENSP00000380271
    RGS20ENSP000002973134STRING: ENSP00000297313
    S1PR3ENSP000003508784STRING: ENSP00000350878
    S1PR4ENSP000002461154STRING: ENSP00000246115
    S1PR5ENSP000003284724STRING: ENSP00000328472
    SSTR1ENSP000002673774STRING: ENSP00000267377
    SSTR3ENSP000003301384STRING: ENSP00000330138
    SSTR4ENSP000002550084STRING: ENSP00000255008
    TBXA2RENSP000003643364STRING: ENSP00000364336
    YES1ENSP000003247404STRING: ENSP00000324740
    ADCY3ENSP000002606004STRING: ENSP00000260600
    CACNA1AENSP000003533624STRING: ENSP00000353362
    CACNA1BENSP000002775494STRING: ENSP00000277549
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001973adenosine receptor signaling pathway IBA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS7961880
    GO:0007186G-protein coupled receptor signaling pathway TAS8587610

    Find genes that share ontologies with GNAI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for GNAI2 gene (6 alternative transcripts): 
    NM_001166425.1  NM_001282617.1  NM_001282618.1  NM_001282619.1  NM_001282620.1  NM_002070.3  

    Unigene Cluster for GNAI2:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
    Hs.77269  [show with all ESTs]
    Unigene Representative Sequence: AK126708
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100
    ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)
    ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422
    ENST00000492383 ENST00000266027 ENST00000536647
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2
    Clone
    Products:
         
    OriGene clones in human, mouse for GNAI2 (see all 11)
    OriGene ORF clones in mouse, rat for GNAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
      QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
      QuantiFast Probe-based Assays in human, mouse, rat GNAI2

    Additional mRNA sequence: 

    AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1 
    AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1 

    Selected DOTS entries (see all 42):

    DT.100680604  DT.97768608  DT.75112974  DT.99968212  DT.91784324  DT.97860778  DT.100680607  DT.100057602 
    DT.95357437  DT.97800888  DT.100059846  DT.100862119  DT.91784320  DT.100059845  DT.120873963  DT.100680601 
    DT.95214674  DT.100648169  DT.100680617  DT.120873971  DT.95185336  DT.120874020  DT.100042317  DT.100859294 

    Selected AceView cDNA sequences (see all 1325):

    BQ924802 BM910681 AL522235 BU629898 BE208389 CA393116 BQ052858 BU632644 
    BQ718640 BQ677998 BE257810 CD613961 BM473715 BQ016684 CR610539 AK126708 
    BQ063369 AI863250 BF969380 BQ181203 BQ438820 BE047986 CD367585 BQ680464 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:              -     -     -     -     -     -     -     -                       -                                         -                                 
    SP2:                                            -     -     -     -                 -                                         -                                 
    SP3:              -     -     -     -     -     -     -     -     -                 -                                         -                                 
    SP4:                          -     -     -     -     -     -     -                 -                                         -                                 
    SP5:                                            -     -     -     -     -           -                                         -                                 

    ExUns: 15f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GNAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNAI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGAA
    GNAI2 Expression
    About this image


    GNAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
     
     Bone (Muscoskeletal System)
             Bone Marrow
    GNAI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77269
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
    QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
    QuantiFast Probe-based Assays in human, mouse, rat GNAI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNAI2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai21 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 91.74(n)1
    98.31(a)1
      9 (58.43 cM)5
    146781  NM_008138.41  NP_032164.21 
     1076141385 
    chicken
    (Gallus gallus)
    Aves GNAI21 guanine nucleotide binding protein (G protein), alpha more 87.32(n)
    95.21(a)
      396367  NM_205402.1  NP_990733.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI26
    guanine nucleotide binding protein (G protein), al...
    91(a)
    1 ↔ 1
    2(148689899-148811953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215122 Xenopus laevis guanine nucleotide-binding protein Gi more 83.72(n)    AF086606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi21e062 wufi21e06 82.55(n)   327650  BC049343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A3 G-protein coupled receptor protein
    signaling pathway more
    76(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA11 GPA1 54.92(n)
    50.14(a)
      856394   NP_011868.1 


    ENSEMBL Gene Tree for GNAI2 (if available)
    TreeFam Gene Tree for GNAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for GNAI2 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):
    GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    Find genes that share paralogs with GNAI2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GNAI2
    PGOHUM00000238547 PGOHUM00000239685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNAI2 (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378532261,2
    Cother150226052(+) GGACCC/G/TGCGTA 6 R G C mis10--------
    rs1491184511,2
    --50204022(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1448643071,2
    --50204071(+) GTCTCC/GATCTC 1 -- us2k10--------
    rs1387130991,2
    --50204100(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1403390471,2
    --50204135(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1454012131,2
    --50204225(+) AACCTC/GCGCCT 1 -- us2k10--------
    rs1924020711,2
    --50204275(+) AGCTGC/GGATTA 1 -- us2k10--------
    rs1474273381,2
    --50204290(+) TGCCCA/GCCACC 1 -- us2k10--------
    rs1483276661,2
    --50204432(+) CAACCA/GTGCCC 1 -- us2k10--------
    rs1154094271,2
    F--50204464(+) TCTAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNAI2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008898CNV Deletion20482838
    dgv5132n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    dgv602n27CNV Loss19166990
    nsv470561CNV Loss18288195
    nsv460531CNV Loss19166990
    nsv523560CNV Loss19592680
    nsv523662CNV Loss19592680
    dgv5131n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): GNAI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139360   
    OMIM disorders: 192605  
    7 diseases for GNAI2:    
    About MalaCards
    ventricular tachycardia, idiopathic    acth-secreting pituitary adenoma    familial hemiplegic migraine type 1    functioning pituitary adenoma
    olivopontocerebellar atrophy    hemiplegic migraine    familial hemiplegic migraine


    Find genes that share disorders with GNAI2           About GenesLikeMe

    Genetic Association Database (GAD): GNAI2
    Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

    Export disorders for GNAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNAI2 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with GNAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)1, 2, 3 Didsbury J.R.... Snyderman R. (FEBS Lett. 1987)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)1, 4 Ruggeri R.M....CannavA^ S. (J. Endocrinol. Invest. 2008)
    5. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)1, 2 Lopez-Aranda M.F.... Khan Z.U. (J. Cell Sci. 2007)
    6. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (J. Cell Biol. 2007)
    7. The -318 C&gt;G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)1, 4 Menzaghi C....Trischitta V. (J. Am. Soc. Nephrol. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2771 HGNC: 4385 AceView: GNAI2 Ensembl:ENSG00000114353 euGenes: HUgn2771
    ECgene: GNAI2 Kegg: 2771 H-InvDB: GNAI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNAI2 gene:
    Search GeneIP for patents involving GNAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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