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GNAI2 Gene

protein-coding   GIFtS: 69
GCID: GC03P050263

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...


(Previous symbol: GNAI2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 21 2
     H_LUCA15.12
GNAI2B1 2 3 5     H_LUCA16.12
GTP-Binding Regulatory Protein Gi Alpha-2 Chain1 2     Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-22
Adenylate Cyclase-Inhibiting G Alpha Protein2 3     Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit2
GIP2 5     

External Ids:    HGNC: 43851   Entrez Gene: 27712   Ensembl: ENSG000001143537   OMIM: 1393605   UniProtKB: P048993   

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNAI2 Gene:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The
encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of
adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for GNAI2 Gene:
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) is a protein-coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic, and acth-secreting pituitary adenoma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
intracellular pool

summary for GNAI2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAI2 gene promoter:
         SRF   CHOP-10   GR   Sp1   SRF (504 AA)   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI2 promoter sequence
   Search Chromatin IP Primers for GNAI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Start:
50,263,724 bp from pter      End:
50,296,787 bp from pter
Size:
33,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2  
Size: 355 amino acids; 40451 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with
UNC5B
Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71
Alternative splicing: 4 isoforms:  P04899-1   P04899-2   P04899-3   P04899-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Explore proteomics data for GNAI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys46, Lys193, Lys198, Lys249, Lys296, Lys307, Lys350
  • Modification sites at PhosphoSitePlus

  • See GNAI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1  

    ENSEMBL proteins: 
     ENSP00000406871   ENSP00000406065   ENSP00000312999   ENSP00000394321   ENSP00000395736  
     ENSP00000406369   ENSP00000266027   ENSP00000444360  
    Reactome Protein details: P04899

    GNAI2 Human Recombinant Protein Products:

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    Novus Biologicals GNAI2 Proteins
    Novus Biologicals GNAI2 Lysate
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    ProSpec Recombinant Protein for GNAI2
    Browse Proteins at Cloud-Clone Corp.

    GNAI2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
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    Abcam antibodies for GNAI2
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    GNAI2 Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P04899

    ProtoNet protein and cluster: P04899

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    GNAI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
    Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
    intracellular pool

         Genatlas biochemistry entry for GNAI2:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    GNAI2 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gnai2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton  tumorigenesis 

    GNAI2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GNAI2: Gnai2tm1Lbi Gnai2tm1Rmm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNAI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNAI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNAI2:
    hsa-mir-30e-5p (MIRT044144), hsa-mir-1 (MIRT023620), hsa-mir-935 (MIRT036699), hsa-mir-30a-5p (MIRT005181), hsa-mir-30d-5p (MIRT003274), hsa-mir-124-3p (MIRT022392), hsa-mir-148b-3p (MIRT043588), hsa-mir-92b-3p (MIRT040616), hsa-mir-877-3p (MIRT036851)

    Block miRNA regulation of human, mouse, rat GNAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNAI2

    Clone
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    OriGene clones in human, mouse for GNAI2 (see all 11)
    OriGene ORF clones in mouse, rat for GNAI2
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GNAI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNAI2_HUMAN, P04899: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell
    membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow
    and/or the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17635935
    GO:0005829cytosol IEA--

    GNAI2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNAI2 About   (see all 83)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 120.74
    G alpha (z) signalling events0.47
    G-protein activation0.74
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    4Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    5G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNAI2 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for GNAI2 (see all 14)
        Signal Transduction of S1P Receptor
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone
    TSH signaling pathway

    Selected Reactome Pathways for GNAI2 (see all 9)
        Regulation of insulin secretion
    G alpha (z) signalling events
    G-protein activation
    Adenylate cyclase inhibitory pathway
    PLC beta mediated events

    3 PharmGKB Pathways for GNAI2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNAI2) (see all 27):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Adrenergic signaling in cardiomyocytes
    Axon guidance
    Tight junction


    GNAI2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAI2 (P048991, 2, 3 ENSP000003129994) via UniProtKB, MINT, STRING, and/or I2D (see all 390)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145981, 2, 3, ENSP000002894734EBI-353997,EBI-395044 MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
    GNB1P628732, 3, ENSP000003678724MINT-7135221 I2D: score=1 STRING: ENSP00000367872
    HSP90AB1P082382, 3MINT-72645 I2D: score=3 
    NCF2P198781, 2, 3, ENSP000003565054EBI-353997,EBI-489611 MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
    CXCR5P323022, 3, ENSP000002921744MINT-50704 MINT-50707 I2D: score=1 STRING: ENSP00000292174
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001973adenosine receptor signaling pathway IBA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS7961880
    GO:0007186G-protein coupled receptor signaling pathway TAS8587610

    GNAI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GNAI2 gene (6 alternative transcripts): 
    NM_001166425.1  NM_001282617.1  NM_001282618.1  NM_001282619.1  NM_001282620.1  NM_002070.3  

    Unigene Cluster for GNAI2:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
    Hs.77269  [show with all ESTs]
    Unigene Representative Sequence: AK126708
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100
    ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)
    ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422
    ENST00000492383 ENST00000266027 ENST00000536647
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GNAI2
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI2
    Clone
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    OriGene ORF clones in mouse, rat for GNAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
    Primer
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    OriGene qPCR primer pairs and template standards for GNAI2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
      QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
      QuantiFast Probe-based Assays in human, mouse, rat GNAI2

    Additional mRNA sequence: 

    AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1 
    AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1 

    Selected DOTS entries (see all 42):

    DT.100680604  DT.97768608  DT.75112974  DT.99968212  DT.91784324  DT.97860778  DT.100680607  DT.100057602 
    DT.95357437  DT.97800888  DT.100059846  DT.100862119  DT.91784320  DT.100059845  DT.120873963  DT.100680601 
    DT.95214674  DT.100648169  DT.100680617  DT.120873971  DT.95185336  DT.120874020  DT.100042317  DT.100859294 

    1325 AceView cDNA sequences (see top 24):

    BQ924802 BM910681 AL522235 BU629898 BE208389 CA393116 BQ052858 BU632644 
    BQ718640 BQ677998 BE257810 CD613961 BM473715 BQ016684 CR610539 AK126708 
    BQ063369 AI863250 BF969380 BQ181203 BQ438820 BE047986 CD367585 BQ680464 
    BG755590 BM673245 H42978 CA417048 BQ680845 BG830529 BE047985 BG397573 
    BU730850 BE795903 BG398309 BQ955180 CF272190 BQ708297 BQ888281 BI669522 
    AI263362 BX475849 BU158574 BG014000 CD515989 BM914867 BU150744 BE741703 
    BQ899266 AI718605 BU188098 BU856128 BM709035 BU543734 AA826069 BP375621 
    BM423419 BM662533 BQ772092 AI288697 BE257887 BU153196 BX342158 BQ677035 
    AW328616 BU528506 BU626280 BU527051 BQ422956 BU194908 BM809344 BG257499 
    AF493906 AW006628 AI863251 BQ773565 BQ927770 BQ682705 AI284196 BE764215 
    AI631364 BM916401 BQ277773 BU557064 BG165758 BQ924793 AW316639 CB140221 
    BQ441013 BG036593 BQ640314 BX421325 BF726024 AY555145 BM836663 CA445804 
    AI364340 AI497940 BM707077 AI754695 BX365050 BQ009020 AI278009 BU190630 
    BU849534 BF931274 AA352263 CA975994 BM663450 BQ233260 BQ641270 BI019079 
    AI051124 BQ182072 BM510749 BG758275 AU134067 CA396030 BF343350 BQ889109 
    AI346142 BM811065 BF969404 CA393856 CR604433 AL534767 AW467255 AI066694 
    AI745677 BG056071 BU845146 BU188569 AI654458 AW628068 BI226311 BG744096 
    M78045 BQ772605 BU183568 AA156673 CA392435 BI758230 BQ446553 BG010831 
    BQ679336 AK096299 BQ128348 AL538576 AI051198 BM708555 AI086922 AL048207 
    BU190649 CD370282 BM554074 BQ677700 AI051636 CD515225 AL589215 BE906978 
    AI688385 AI301376 AI810594 CR599468 AA331041 AI824708 BU196095 BQ216760 
    BQ893578 AW062609 BG177488 NM_002070 AA357896 BQ008949 AW613283 AK096595 
    CK823725 BE274665 BU501163 CR609921 AI753997 BQ775600 BE544580 AI634954 
    BM554824 CA416342 AI302543 BQ953533 BM667974 BG925946 BG768352 BU527197 
    AI860738 BE879537 CD742775 BU845251 BG119048 BE302918 BU689061 BQ895963 
    AI758978 BC014627 BE764177 BU501565 BM710071 H09869 BI032154 CB161952 
    BM917082 AW518417 BQ882379 CR606737 CR618994 AA376085 BE620085 BU732495 
    CD557583 CR593068 BQ436514 BI855804 BX438782 CB155184 BQ478294 CR603761 
    BG013947 BQ017223 CD106402 BC012138 AW069760 BP341236 BM987426 CA449568 
    BQ642357 AW592365 BQ421415 AI253532 CD244774 BQ891630 BC016995 BE744409 
    BQ676408 BQ229993 BQ943631 AI272776 BM671231 BE764334 CD366959 BU165695 
    AW841412 BQ071241 BI822447 BG830523 AL538225 BQ641884 BX101230 AK131062 
    BU689008 AA071330 BM470078 AI819620 BG419614 BG325570 BX354496 CA443560 
    BQ183030 R73791 BE379179 AW168703 CD613959 BF792226 BQ676398 AI632039 
    N63945 AK055574 BE386880 BX434229 BU753808 BQ003529 AI879911 BG424931 
    BE884332 BG758289 BG926076 R65785 BQ787364 BI025386 BG706293 AI335327 
    W95126 AW673500 CA442956 BG419629 CD742618 BG255714 AI086553 BQ231358 
    BE736750 AL546769 BE312531 BQ641548 AL539321 AL560481 BG283523 AI421817 
    BQ710188 BG328284 N90833 BE743897 BG327352 AI735650 AI356113 AL544037 
    CF131670 BF969526 BF974634 AA340712 BE267693 BE905240 BF724437 BI223125 
    BE390122 BG395861 BX333895 CA425455 BF973583 AI619812 BG748111 AW195251 
    BX397874 BG249901 BG284734 BF238048 CA442212 AW008068 R79746 BE789421 
    BM970706 AA641164 BI049505 BU153772 BG120130 AL542151 AL040479 BF724537 
    BE388398 BQ213416 BQ050987 BM805599 AU133764 AA352548 AI199372 BE768854 
    AA312561 AI652206 BM996695 BM800958 BF688728 AI371359 BX439360 BX338239 
    BU855766 BQ004592 BI669179 BX462671 BQ016630 BE296368 BM083882 BG753237 
    BG911310 R73790 BE613549 BF966098 BQ268343 BG829756 CB146196 BX420207 
    AW470200 AA868336 BX412273 BI597776 AU119572 BM007873 BG706694 BX397985 
    AI369702 BX337967 BF685795 BP381420 BM544812 BM697339 BG392748 BU617634 
    AU122343 BM711629 AI678726 BQ649602 BG708979 BQ896789 BE513827 BQ939721 
    BM007518 BM453390 BX390790 BF929663 BQ676471 BQ641751 BM980072 BU156759 
    BG341557 BM837613 BE877023 BE388667 AL572075 BE745787 BX419817 BI758631 
    AW410490 BG259153 BQ959034 AI719793 AI214346 CA442174 BI596562 BM453026 
    BG326289 CB305457 BU617504 AW997307 BG438096 BG326621 BM043610 BG421451 
    AU138381 BG684765 AL572705 BI117598 BG680258 BX427731 BX462658 BM809516 
    BG056784 BG741443 BG700356 BX337250 BF924453 BX380187 BX455957 BM908033 
    BX439320 BX447699 CR456783 BE251585 BX415242 BF972918 BQ645763 BQ025625 
    BG112875 BE303019 BQ932757 BM751249 CA448305 BM424269 AW473399 AI817579 
    AU121736 BE277381 BQ055805 BE166176 BU172209 BI596294 AU139927 BE743458 
    BF688951 CF142388 BX356500 AA410774 BE886968 BI192553 BE878546 BI826133 
    BU556898 BQ689245 BG424150 BG829627 BG419509 BE018931 AW339637 BI260075 
    BM687275 BX443316 BQ673193 BG749009 BE764169 BE876724 AL534766 BG775195 
    BQ680554 BG477289 AW044429 BQ672264 BG705663 BX443036 AI203552 BI667189 
    AW192103 BM808625 BI049510 BE905426 AA426222 AA604809 BU178808 BG028953 
    BG034282 BM558784 BI004068 AU122479 BG337479 CD246097 BM758142 AA463243 
    BM691477 BI458337 BQ233822 T50047 CA413098 BQ677862 F30187 BG912177 
    BE882854 BG334690 CN483896 AI114629 AL537372 BM687845 BF799505 BG926077 
    AI921342 BI196801 BM424075 AI566302 AL048206 BX337966 BE612558 AW070661 
    BE388618 BG116501 BE394699 BU859205 AU121403 BG754895 AI936050 BG341509 
    BG425220 BM757843 BG575030 BX419047 CA446117 AA056418 BE395455 AA393511 
    BI032190 BG424558 BG036595 AA554351 BG767110 BI335746 BE740640 AW610091 
    BM554480 AW043734 BQ710882 F24983 AL546241 BQ006061 BM832400 BI457934 
    AI373086 BF841922 BF206239 BU627156 BI024771 BG326706 BE907003 BE885091 
    BQ884262 AA720666 BG034830 R65882 BG763313 AI865293 CD613960 BF961210 
    AA031382 BI603556 BM045978 BG752074 AA745703 BG745687 T89634 BG679788 
    BG678190 AI042073 BE785513 BM510995 BU155150 BI522456 BE464812 BV178757 
    BU845773 BX426451 BX340460 AA031383 BF924620 AI074591 BG750333 BG437182 
    AW084018 AL551940 BE535260 AL567386 BM707314 BM808944 AA366897 BX412487 
    AW589869 AI554363 BG179277 BX427732 BE513816 AI784297 BG749994 BI756299 
    BQ772948 BG714915 BG437180 BG469608 AA788707 BG766252 BF792483 AI281419 
    AL541652 BG472088 BG708610 BF966980 BG706941 AW934885 BX356501 AU118196 
    BG770219 CB565939 AI818517 C04973 BE391528 BU598659 H98929 AW949139 
    BM477888 AI193136 BG110026 BG768391 AW401914 AL134315 BF527916 BF125906 
    BM978619 AV703446 AA022566 CD742909 AI911924 BE221562 BG105543 AW083657 
    BG758856 BI193867 AA156845 X04828 BI024774 BF026307 BG472705 BM801249 
    AA808565 BQ308314 BU554079 AA705914 BG424492 H26819 BE857408 AW675824 
    AA339313 BM810284 BP360722 T50133 BF894175 BG419493 BF445258 AA355122 
    CA311070 BG703999 AA427508 AA886787 CB164390 AW328615 BX398332 AW974240 
    BE840208 AA043024 AA143701 AL539320 BI019085 BG758897 AW117352 BM755574 
    CA443140 BE707035 BG744761 BG900647 AW577323 BQ270288 BG398505 BE909209 
    AA825639 BF797826 AI560496 AW192845 AL575393 BE300695 AA309861 BG325002 
    AA071395 AA398683 BI031071 BX365049 BI027000 CB528306 BF884813 BF892220 
    AI953918 AW402459 BG256517 BQ680588 AI082060 BE561870 BG770370 BI198079 
    AI024048 AI077914 AA310519 BX439782 AA599162 AA435574 AW239314 AW518732 
    BQ335804 BE676196 AI866578 BE775101 AA621030 AA779111 AI032191 AI678725 
    BI193219 AW403988 BE077451 AI718822 BF341589 BQ694945 AI022366 BF847451 
    AW404082 BX374183 AA558596 CA407901 AW403614 BE256856 BX397873 AW949152 
    AA301617 BQ071309 BE271864 BG419218 BX397984 AU128300 AW087846 BG702829 
    BM996772 BE728009 AL542915 H09782 BI026525 AW103382 BM973082 BE410840 
    AI439572 BU608179 AU137211 AI051277 AL547952 AU145880 BQ022154 AA374040 
    BX458650 BE276967 BF313294 BG928101 CD613958 BF856412 N25944 BX354495 
    AW250669 BG388454 AI367560 AA346062 AI749299 BE775080 CF130351 BG114229 
    BI027706 BU157729 AA587611 BX340459 BQ694570 BG341853 BU070356 AI524057 
    CD366478 BF836727 AI289140 BG478725 BQ678567 BF685510 AA318336 BG754295 
    BI029584 BI222647 BU187539 N99977 AI214255 BE728653 AW470978 AV724507 
    BF027510 BQ682876 BE277367 BI027685 BF972392 BI029527 R55009 AA825168 
    BE264522 BE895895 BG315486 BF892200 CA311706 BF342245 BQ335797 BI032182 
    BE273674 AW581572 BG766650 AW029602 D55766 BF746380 BU595766 BE730573 
    AW405532 AI827336 BP382802 BG341977 BF926143 BI032169 BI025366 BM998902 
    AI095262 BE387519 BP337283 BQ335529 AL538224 AA507944 CA442155 BX439496 
    BE743610 AA150566 BI024773 AA742880 AA302304 BI029569 AA834118 AA426340 
    BG825204 H98930 BG898278 BE674704 BG252859 BF315848 AL581923 AI925309 
    J03004 BG925632 BE840214 BG027779 BI026903 AA947697 BF849659 BF745941 
    BF982283 AU147941 AA770230 AJ714329 BQ478541 BF725063 BX373447 CD108083 
    BF088230 AA402372 AL589214 BI026511 BX400044 BE049521 N53884 AA775047 
    BM923124 CB053759 BE165004 BF744305 AA570039 BI027613 BE613127 BQ128084 
    BE221576 AA042942 AW339153 AI033446 AI925052 BE164960 AI799660 AA503704 
    AU123366 AY677118 BQ335302 BI026522 BE301141 AI445986 AL539047 BG339225 
    BI024854 BG421631 BF026512 BX360799 AW470187 BU553684 BI030991 BM991341 
    AA463242 BE301333 BF976286 AW005698 BF894583 BG424908 BE812166 BI063057 
    BE260131 BF884822 BF924628 BF754433 BE261580 BE892978 BM988930 BF822028 
    AI298706 AA492523 T89908 BG924312 AI609037 W30915 BF903297 CN481111 
    BF896968 AW972131 AI554724 BF238271 BE812436 AI202278 AA426292 AI831822 
    W95243 BG001603 BG469929 BX460269 AL562077 R48501 N22803 BF888075 
    CK823726 BG469553 BF971682 BX337249 BQ683228 W57705 AW834751 BM990414 
    BM969827 BG955580 BF992182 AA814850 BF746715 BE075103 M78077 BE703188 
    BF907558 BM685542 BE164975 BF991994 BF901562 BM911400 AI808948 BF882153 
    BI026515 CA418909 AW364589 BI005481 BX335983 BI032195 BI032168 BQ329313 
    BF888239 AI222802 N99974 AI247091 T50186 BI024858 AI004907 BF381319 
    T83509 BF892878 AA758175 BE799201 BF851261 AI571771 AL570278 AA235314 
    BQ213254 AL542150 BI031613 BI015034 BE300583 AW875257 AW382970 BF359980 
    N41058 BE274029 BQ922937 BI226819 BF907550 BI025356 AW177533 AA054711 
    AL569010 AI479427 AU147223 AW401925 N79620 AU077008 AW402537 BI820895 
    R55147 N71969 BI024844 CA434927 BE620624 BE873631 BG340425 AA377330 
    BI497152 AA936741 BF924450 BU185240 BF907626 BM705197 BG961464 AA974549 
    BG009219 AA747263 AI274934 AI749027 BE931522 BI052732 BM544820 BI029917 
    AW467693 BG001581 BG272345 AW733133 R79747 AA744927 F32885 AL567638 
    BF941022 BE745340 BE840018 AI869387 BE843342 AA877195 BF991900 AI933609 
    N63188 AA844391 BM471553 BF381314 BQ335341 BE867750 BF340952 BI767768 
    AW402290 BQ375709 AA832370 BG014797 BF930530 BQ336024 AW382968 BF891833 
    BF746381 AA082081 BE932761 CD613962 AA302582 BF858473 AI864159 BF745946 
    AA046537 AI582580 AW294467 BM806165 BE906351 BI830676 BI003688 BF746477 
    BF888118 AW403078 BF747004 AA976611 BE931519 AA263075 BF898515 BF888184 
    AL549484 BF856543 BI027814 BE843754 AL571766 BI523643 BE075156 BF341900 
    AA649233 W30912 BG315289 AW384366 AI125123 BF381301 BF733224 BG471840 
    CB053758 BG479921 AA331038 BI028416 BF745922 BI192848 BF888004 BG982795 
    BF892321 AW608655 BG477040 BU556720 BF894232 BF745943 BF745938 BF907539 
    BF746468 BX423516 BQ213091 BU190333 BF746989 BQ676921 BE843756 BE964910 
    BF879473 BG013416 BX412168 AA996268 BQ335913 BF907556 BF127475 BF746470 
    BF754430 AW177010 CD613963 BF907602 AW577115 BX379860 BF754442 AW385989 
    C03696 BF951533 BF826501 BE764284 BF746471 BG003437 BU179827 BX454546 
    BG421317 AL537371 BF746466 BF868873 N99701 BG822093 BF744306 BF310395 
    BF381337 BQ371687 BF991986 R91731 BI021065 BG988464 BF746476 BQ959314 
    BF857606 AA284200 BF907544 BF907620 BF987808 BQ057235 BF894102 BF907601 
    AW608678 BF907560 BF896970 BI602933 BF799675 AA865809 BF962637 BF907522 
    BF746475 BI024501 BQ379181 BE077286 BE707106 BU540381 BF744293 BF878273 
    AA618189 BF746469 BF745928 BF935330 BF746370 T54397 BF381303 BF745932 
    BG271528 AI885088 BG002168 BQ375737 BQ379547 BF888126 U46292 T28912 
    BI029510 BF745927 BF746472 BE907698 BQ366246 BQ379612 BF907526 BG987912 
    BQ379171 BF764751 BF933759 AA737483 BF907546 BE768404 BE768405 BF026011 
    AA146751 BQ304757 BF888183 BF381322 BF933766 BI024736 AA531365 BQ677899 
    BF745940 BI030904 BU959910 AW380135 BF746991 BP343982 BI061786 BQ329334 
    BQ336066 H26931 D53047 AI540349 CA443160 BF933594 BE255372 BE786630 
    BF888262 BG686900 BQ379189 BQ676813 CF264739 CD639897 AV699896 BI024776 
    BF744312 BI024887 BQ379175 AL569685 BQ898461 AW498834 BM913269 BQ681167 
    T54288 BP338515 BQ335783 AA878937 BF746453 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:              -     -     -     -     -     -     -     -                       -                                         -                                 
    SP2:                                            -     -     -     -                 -                                         -                                 
    SP3:              -     -     -     -     -     -     -     -     -                 -                                         -                                 
    SP4:                          -     -     -     -     -     -     -                 -                                         -                                 
    SP5:                                            -     -     -     -     -           -                                         -                                 

    ExUns: 15f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GNAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GNAI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGAA
    GNAI2 Expression
    About this image


    GNAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
     
     Bone (Muscoskeletal System)
             Bone Marrow
    GNAI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77269
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GNAI2
    QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
    QuantiFast Probe-based Assays in human, mouse, rat GNAI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNAI2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai21 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 91.74(n)1
    98.31(a)1
      9 (58.43 cM)5
    146781  NM_008138.41  NP_032164.21 
     1076141385 
    chicken
    (Gallus gallus)
    Aves GNAI21 guanine nucleotide binding protein (G protein), alpha more 87.32(n)
    95.21(a)
      396367  NM_205402.1  NP_990733.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI26
    guanine nucleotide binding protein (G protein), al...
    91(a)
    1 ↔ 1
    2(148689899-148811953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215122 Xenopus laevis guanine nucleotide-binding protein Gi more 83.72(n)    AF086606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi21e062 wufi21e06 82.55(n)   327650  BC049343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A3 G-protein coupled receptor protein
    signaling pathway more
    76(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA11 GPA1 54.92(n)
    50.14(a)
      856394   NP_011868.1 


    ENSEMBL Gene Tree for GNAI2 (if available)
    TreeFam Gene Tree for GNAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNAI2 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):
    GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    GNAI2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GNAI2
    PGOHUM00000238547 PGOHUM00000239685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNAI2 (see all 400)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378532261,2
    Cother150226052(+) GGACCC/G/TGCGTA 6 R G C mis10--------
    rs1491184511,2
    --50204022(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1448643071,2
    --50204071(+) GTCTCC/GATCTC 1 -- us2k10--------
    rs1387130991,2
    --50204100(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1403390471,2
    --50204135(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1454012131,2
    --50204225(+) AACCTC/GCGCCT 1 -- us2k10--------
    rs1924020711,2
    --50204275(+) AGCTGC/GGATTA 1 -- us2k10--------
    rs1474273381,2
    --50204290(+) TGCCCA/GCCACC 1 -- us2k10--------
    rs1483276661,2
    --50204432(+) CAACCA/GTGCCC 1 -- us2k10--------
    rs1154094271,2
    F--50204464(+) TCTAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNAI2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008898CNV Deletion20482838
    dgv5132n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    dgv602n27CNV Loss19166990
    nsv470561CNV Loss18288195
    nsv460531CNV Loss19166990
    nsv523560CNV Loss19592680
    nsv523662CNV Loss19592680
    dgv5131n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): GNAI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139360   
    OMIM disorders: 192605  
    Selected diseases for GNAI2 (see all 31):    
    About MalaCards
    ventricular tachycardia, idiopathic    acth-secreting pituitary adenoma    non-functioning pituitary adenoma    functioning pituitary adenoma
    olivopontocerebellar atrophy    noonan syndrome    pituitary adenoma    trypanosomiasis
    fainting    toxoplasmosis    chagas disease    pertussis
    adenoma    labyrinthitis    huntington's disease    insulin resistance
    neuroblastoma    multiple sclerosis    cystic fibrosis    retinitis


    GNAI2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNAI2
    Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

    Export disorders for GNAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNAI2 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with GNAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)1, 2, 3 Didsbury J.R.... Snyderman R. (FEBS Lett. 1987)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)1, 4 Ruggeri R.M....CannavA^ S. (J. Endocrinol. Invest. 2008)
    5. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)1, 2 Lopez-Aranda M.F.... Khan Z.U. (J. Cell Sci. 2007)
    6. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (J. Cell Biol. 2007)
    7. The -318 C&gt;G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)1, 4 Menzaghi C....Trischitta V. (J. Am. Soc. Nephrol. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2771 HGNC: 4385 AceView: GNAI2 Ensembl:ENSG00000114353 euGenes: HUgn2771
    ECgene: GNAI2 Kegg: 2771 H-InvDB: GNAI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GNAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GNAI2 gene:
    Search GeneIP for patents involving GNAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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