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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNAI2 Gene

protein-coding GIFtS: 70
GCID: GC03P050263

guanine nucleotide binding protein (G protein), alpha inhibiting...

(Previous symbol: GNAI2B)

Explore 26 diseases affiliated with
GNAI2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2¹ ²		H_LUCA16.1²
GNAI2B¹ ² ³ ⁵		GTP-Binding Regulatory Protein Gi Alpha-2 Chain²
GIP¹ ² ⁵		Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-2²
Adenylate Cyclase-Inhibiting G Alpha Protein² ³		Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit²
H_LUCA15.1²

External Ids:	HGNC: 4385¹	Entrez Gene: 2771²	Ensembl: ENSG00000114353⁷	OMIM: 139360⁵	UniProtKB: P04899³

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNAI2:

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded

protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase.

Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature

of only two are known so far. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they

inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division

Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an

intracellular pool

summary for GNAI2:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind

directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in

cAMP levels respectively.

Gene Wiki entry for GNAI2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNAI2 gene promoter:
SRF CHOP-10 GR Sp1 SRF (504 AA) GR-alpha C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNAI2 promoter sequence

Search SABiosciences Chromatin IP Primers for GNAI2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P050263: view genomic region (about GC identifiers)

Start:	50,263,724 bp from pter	End:	50,296,787 bp from pter
Size:	33,064 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2

Size: 355 amino acids; 40451 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide

binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cell membrane. Note=Localizes in the centrosomes

of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody

Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71

Alternative splicing: 4 isoforms: P04899-1 P04899-2 P04899-3 P04899-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04899

GNAI2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001159897.1 NP_002061.1

ENSEMBL proteins:

ENSP00000406871 ENSP00000406065 ENSP00000312999 ENSP00000394321 ENSP00000395736

ENSP00000406369 ENSP00000266027 ENSP00000444360

Reactome Protein details: P04899
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GNAI2 OriGene Protein Over-expression Lysate: GNAI2 OriGene Custom Protein Services for GNAI2
	GenScript Custom Purified and Recombinant Proteins Services for GNAI2
	Novus Biologicals GNAI2 Proteins Novus Biologicals GNAI2 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for GNAI2
	Uscn Proteins for GNAI2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	17635935
GO:0005813	centrosome	IDA	17635935
GO:0005829	cytosol	IEA	--

GNAI2 for ontologies About GeneDecksing

GNAI2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
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	Browse OriGene Antibodies OriGene Custom Antibody Services for GNAI2
	GenScript Superior Antibodies for GNAI2
	Novus Biologicals GNAI2 Antibodies
	Abcam antibodies for GNAI2
	Uscn Antibodies for GNAI2
	ThermoFisher Antibody for GNAI2

Assay Products for GNAI2:

	EMD Millipore Kits and Assays for the Analysis of GNAI2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GNAI2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GNAI2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNAI2 for domains About GeneDecksing

3 InterPro domains/families:

IPR001019 Gprotein_alpha_su

IPR011025 GproteinA_insert

IPR001408 Gprotein_alpha_I

Graphical View of Domain Structure for InterPro Entry P04899

ProtoNet protein and cluster: P04899

2 Blocks protein families:

IPB001019 Alpha G-protein (transducin) signature

IPB001408 G-protein alpha subunit group I signature

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they

inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division

Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an

intracellular pool

Genatlas biochemistry entry for GNAI2:

guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

miRNA Products:		miRTarBase miRNAs that target GNAI2: hsa-mir-30a (MIRT005181), hsa-mir-30d (MIRT003274)

		OriGene 3'-UTR Clone: GNAI2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAI2
		8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI2 (see all 68):
		hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: GNAI2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAI2 (see all 7) OriGene shRNA RFP: GNAI2 OriGene siRNA: GNAI2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAI2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNAI2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNAI2
		Search LifeMap BioReagents cell lines for GNAI2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IBA	--
GO:0003924	GTPase activity	IBA	--
GO:0004871	signal transducer activity	IBA	--
GO:0005515	protein binding	IPI	16189514
GO:0005525	GTP binding	IEA	--

GNAI2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for GNAI2: Gnai2^tm1Uru Gnai2^tm1Lbi Gnai2^tm1Rmm
     13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gnai2):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	respiratory system	tumorigenesis

GNAI2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/78 super-pathways (see all 78) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

1

Development Angiotensin activation of ERK

	8/9 pathways (see all 9)
	Development Angiotensin activation of ERK	1.00			Development G-Proteins mediated regulation MARK-ERK signaling	0.66
	Development_Angiotensin activation of ERK	0.98			Development_EDNRB signaling	0.54
	Development_ACM2 and ACM4 activation of ERK	0.74			Development EDNRB signaling	0.54
	Development ACM2 and ACM4 activation of ERK	0.74			Cholinergic synapse	0.30

2

Development_Dopamine D2 receptor transactivation of EGFR

	Development_Dopamine D2 receptor transactivation of EGFR	1.00			Development Alpha-2 adrenergic receptor activation of ERK	0.66
	Development Dopamine D2 receptor transactivation of EGFR	1.00			Chemotaxis_CXCR4 signaling pathway	0.48
	Development_Alpha-2 adrenergic receptor activation of ERK	0.66			Chemotaxis CXCR4 signaling pathway	0.48

3

Opioid Signalling

	Opioid Signalling	1.00			Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	0.35
	G-protein mediated events	0.55			Glutamatergic synapse	0.31
	PLC beta mediated events	0.54

4

G Protein Signaling Pathways

	G Protein Signaling Pathways	1.00			Signal transduction_PKA signaling	0.23
	Signal transduction cAMP signaling	0.44			Signal transduction PKA signaling	0.23
	Signal transduction_cAMP signaling	0.44

5

G-Beta Gamma Signaling

	G-Beta Gamma Signaling	1.00			Relaxin Pathway	0.32
	GHRH Signaling	0.46			Hedgehog Signaling in Mammals	0.22
	CRHR Pathway	0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 EMD Millipore Pathways for GNAI2 (see all 23)

	Chemotaxis CXCR4 signaling pathway
	Development A1 receptor signaling
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Integrin inside-out signaling
	Development G-Proteins mediated regulation MARK-ERK signaling

5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI2 (see all 57)

	RhoA Pathway
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	CDK5 Pathway

5/25 GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)

	Signal transduction cAMP signaling
	Development Endothelin-1/EDNRA signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein alpha-i signaling cascades
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

5/13 BioSystems Pathways for GNAI2 (see all 13)

	Signal Transduction of S1P Receptor
	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways
	TSH signaling pathway
	S1P4 pathway

5/24 Reactome Pathways for GNAI2 (see all 24)

	Transmission across Chemical Synapses
	Metabolism
	Regulation of Insulin Secretion
	Neuronal System
	Opioid Signalling

3 PharmGKB Pathways for GNAI2

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

5/14 Kegg Pathways (Kegg details for GNAI2) (see all 14):

	Chemokine signaling pathway
	Axon guidance
	Tight junction
	Gap junction
	Leukocyte transendothelial migration

GNAI2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GNAI2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/351 Interacting proteins for GNAI2 (P04899^{1, 2, 3} ENSP00000312999⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 351)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCF2	P19878²^,³, ENSP00000356505⁴	MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
NCF1	P14598²^,³, ENSP00000289473⁴	MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
MAP3K3	Q99759²^,³, ENSP00000354927⁴	MINT-48437 I2D: score=2 STRING: ENSP00000354927
GNB1	P62873²^,³, ENSP00000367872⁴	MINT-7135221 I2D: score=1 STRING: ENSP00000367872
HSP90AB1	P08238²^,³	MINT-72645 I2D: score=3

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	IEA	--
GO:0001973	adenosine receptor signaling pathway	IBA	--
GO:0006184	GTP catabolic process	TAS	9637720
GO:0007049	cell cycle	IEA	--
GO:0007165	signal transduction	TAS	9637720

GNAI2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNAI2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Mastoparan X	G protein activator peptide	[72093-22-2]
Mastoparan	Activates Gi and Go	[72093-21-1]
Pertussis Toxin	Catalyzes ADP-ribosylation of Gi, Go and Gt	[70323-44-3]
Melittin	Inhibits Gs and stimulates Gi activity	[20449-79-0]
NF 023	Selective, competitive P2X antagonist	[104869-31-0]

3 HMDB Compounds for GNAI2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNAI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNAI2 gene (2 alternative transcripts):

NM_001166425.1 NM_002070.2

Unigene Cluster for GNAI2:

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Hs.77269 [show with all ESTs]

Unigene Representative Sequence: AK126708

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100

ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)

ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422

ENST00000492383 ENST00000266027 ENST00000536647

miRNA Products:		OriGene 3'-UTR Clone: GNAI2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAI2
		8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI2 (see all 68):
		hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: GNAI2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNAI2 (see all 7) OriGene shRNA RFP: GNAI2 OriGene siRNA: GNAI2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNAI2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNAI2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): GNAI2 (NM_002070)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAI2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNAI2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAI2

Additional cDNA sequence:

AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1

AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1

24/42 DOTS entries (see all 42):

DT.100680604 DT.97768608 DT.75112974 DT.99968212 DT.91784324 DT.97860778 DT.100680607 DT.100057602

DT.95357437 DT.97800888 DT.100059846 DT.100862119 DT.91784320 DT.100059845 DT.120873963 DT.100680601

DT.95214674 DT.100648169 DT.100680617 DT.120873971 DT.95185336 DT.120874020 DT.100042317 DT.100859294

1325 AceView cDNA sequences (see top 24):

BQ680845 CR606737 AF493906 BU730850 BI032154 BM663450 BE741703 BQ895963

CD515989 AI066694 BQ009020 BU689061 BM708555 BU153196 AK096595 BQ893578

BQ927770 BE302918 AI654458 BQ899266 BU158574 CA393116 BG165758 BQ676408

BU557064 AW069760 BQ772092 BX475849 AK096299 BE047986 BQ128348 CD367585

AI688385 BM667974 BQ216760 BP375621 AI753997 BM987426 BQ052858 BQ008949

AI302543 BQ924802 CK823725 BQ677035 AW328616 BP341236 BG398309 AI284196

BE764215 BG397573 CD557583 AY555145 BG744096 BQ181203 BQ017223 BU543734

AI810594 BQ446553 BQ888281 BE257810 AI863250 AW006628 BF969404 CD613961

BM910681 AI497940 BX365050 CA416342 AI051198 BM811065 BE047985 AL589215

BQ640314 BU845146 BQ955180 BQ016684 BQ924793 BQ680464 BE620085 BG036593

AI634954 BG257499 BU501565 BC014627 CR603761 BQ421415 BI758230 AI288697

BM662533 BQ063369 AA156673 BG014000 BU183568 BX342158 AL534767 AI745677

BM554074 BM914867 BM916401 BQ682705 BQ233260 BI855804 BG925946 BQ677700

AI863251 BQ438820 CD742775 CD244774 BE795903 M78045 BU188098 BM554824

BU501163 BC012138 BU190649 BE879537 BQ772605 CB161952 BG768352 BQ677998

BU194908 BQ891630 CA975994 CB140221 CD515225 AW613283 BU629898 AI860738

BG010831 BQ953533 BQ642357 BM917082 CR609921 BE906978 AI364340 BF726024

CD106402 BQ882379 BG119048 BU196095 AI824708 CA417048 BU528506 BQ441013

BM709035 BX438782 BM473715 BE274665 AI051636 CR610539 BQ708297 BG013947

BU190630 AA376085 AI758978 AI754695 BQ718640 BM510749 AI301376 BE208389

BI669522 BE764177 H09869 BU527197 BQ422956 BM423419 BG830529 CD370282

BM673245 AA352263 BQ773565 BU527051 AI272776 AI263362 BG177488 AI278009

AI631364 CR618994 BG056071 CR604433 BU845251 BE544580 CA392435 BF969380

BU856128 AK126708 AL538576 AA357896 BQ182072 AI051124 BF931274 AW628068

BQ679336 AA331041 BC016995 BQ943631 AW316639 BQ277773 BI226311 BG755590

BU632644 BQ478294 NM_002070 AI086922 CR599468 BQ775600 BU849534 BM809344

AI253532 BQ229993 AI718605 BI019079 CR593068 BE744409 CA445804 AW467255

CB155184 BU626280 BQ436514 H42978 AL522235 AI346142 CA449568 BU732495

CA396030 BM836663 BU188569 BE257887 AW592365 BU150744 AW062609 CA393856

BM707077 AW518417 BQ889109 BF343350 AA826069 AL048207 BX421325 CF272190

BQ641270 AU134067 BG758275 BM710071 AI819620 AL572705 CA442212 AA720666

BX354496 AI281419 BQ710882 BI196801 BX333895 BG283523 BX337966 BG741443

BF973583 BI025386 BU689008 BG750333 BE886968 BI335746 BM558784 AI421817

CN483896 BU845773 BX434229 BG284734 AL040479 BX101230 BG249901 BM832400

F24983 BF685795 BG714915 BM980072 BE905240 BM996695 BG337479 BF974634

BE907003 BG706293 BG112875 BQ896789 BE745787 AI784297 BX420207 BG425220

BI758631 CA413098 CA446117 BQ645763 AL560481 AW008068 CF131670 BG758289

BQ003529 T89634 AI371359 BX439360 BQ213416 BX338239 BG424558 BG700356

AI817579 AL546241 BM424075 BU859205 BQ932757 AA745703 BI049510 BU855766

AW841412 BG829756 BQ641884 AA554351 BE513816 BQ183030 AU121403 BG749994

AA868336 BI826133 BI223125 BX443316 BG754895 CD246097 BG678190 BU617504

BV178757 AA031383 BM045978 BG926076 AL048206 BI596294 AW610091 BM808625

BQ939721 BM554480 AI936050 BF961210 BM007518 AW192103 AU139927 AI373086

AW410490 BE740640 BX462658 AI074591 BG326706 BG328284 AU119572 BQ959034

AA788707 CB305457 AW473399 BE764169 BF929663 AL544037 BM697339 BM758142

BG926077 BG326289 BU155150 AI818517 AU121736 BU556898 AA056418 BG708979

BG419614 BG763313 BM671231 BG325570 BG680258 AA352548 BF924620 AU122479

BE789421 BX412273 BG419509 BQ641548 BX427731 AA312561 BE464812 AL567386

N90833 BF799505 BE166176 AI879911 BQ710188 BI822447 BG326621 AU118196

AA340712 CA443560 BQ050987 BE612558 BG477289 BI117598 BG437182 BG708610

BU165695 BG575030 BG437180 BE882854 BM687275 BE390122 BQ055805 BG749009

BQ673193 BG684765 BX397985 BI032190 BG034830 BG469608 BE394699 BM043610

BM809516 BG327352 CF142388 BE513827 CA442956 AI566302 BM470078 BG705663

CD366959 AI719793 AW168703 BM711629 BM805599 AA393511 BF688728 BQ231358

BG034282 BU156759 R73791 BE885091 AI203552 AL551940 AL572075 R79746

BM687845 AU122343 BE395455 BG706694 BG911310 BE613549 R73790 BF924453

BX419817 BF206239 BU172209 BG424150 BX415242 BM007873 BI667189 N63945

BE535260 BG829627 BX419047 BG259153 CA425455 BX340460 BG341509 BM083882

BX427732 BG419629 BE296368 BX356500 BQ016630 BQ772948 BQ233822 BM510995

BX426451 BG255714 AI214346 BF792483 AA426222 AK131062 BG766252 BQ676471

R65882 BF238048 BE388618 BI669179 BU153772 BG116501 BQ071241 AW084018

BF966098 BG334690 BG421451 BE388398 CB146196 BE877023 BE386880 BQ004592

BM453390 AI865293 BG179277 BM691477 BQ672264 BQ641751 BG341557 AI735650

BQ006061 BX447699 BG745687 BE743458 BG775195 BI024771 BI603556 BE251585

BG752074 BQ787364 BE884332 BX455957 AU133764 CA448305 AL539321 BI597776

AA641164 AW339637 BU178808 AW070661 BI522456 BG770219 AU138381 BI260075

F30187 AA604809 BE277381 AI619812 CB565939 AI632039 AI921342 BF841922

AA031382 BX337250 BG028953 BM544812 BM453026 BE379179 BG392748 AI086553

BX439320 BE878546 BG706941 BG036595 BG679788 BE736750 BE018931 BG912177

BG056784 AI356113 AK055574 BM757843 BE785513 CD613960 BP381420 BE743897

BM970706 BF724437 BI457934 BE388667 BI596562 BX337967 BF724537 BG120130

BG748111 BE905426 R65785 BX412487 BQ268343 AI369702 BG753237 BQ649602

AW470200 T50047 BG438096 BI756299 BE876724 AI678726 BM751249 AW195251

AI554363 BM424269 BE312531 AA071330 CR456783 BM908033 CD613959 AL538225

BG830523 AW589869 AI335327 AW934885 BI004068 AI042073 AL537372 BE764334

BF966980 BX462671 BI049505 AA410774 CA442174 BU753808 BX390790 BF969526

AW043734 AW044429 BM808944 AA366897 BX356501 BF688951 BI192553 BM837613

BG395861 BI458337 AI652206 BE768854 BX397874 BU627156 AL534766 AL546769

BQ676398 BE267693 AL542151 BQ025625 BF972918 AW673500 BQ677862 BQ680554

AA463243 AI114629 W95126 BM707314 BG767110 BF792226 BU617634 BM800958

AI199372 BE303019 CD742618 BG472088 BQ884262 BG424931 BX380187 BX443036

AL541652 BQ689245 AW997307 BE271864 BQ308314 BX374183 AI678725 AA374040

AA779111 AI193136 CA407901 BE728653 BG758856 BG768391 AA071395 BM801249

AI524057 BF847451 CF130351 BG758897 BI026525 AI214255 BM755574 BG341853

BG928101 BM973082 AA808565 AI718822 BM810284 BF892220 AW239314 BE676196

BF125906 AW328615 AL547952 BE256856 BQ694945 BE077451 AA599162 BU608179

AW949139 BI029584 AW949152 BI193219 AW117352 BG110026 AI367560 BX354495

AI022366 AI024048 BG105543 AA558596 AA398683 N99977 AW518732 AA309861

BX340459 AA705914 C04973 BX365049 BE775080 AL542915 T50133 BF894175

BU157729 BU598659 BU187539 BI019085 BG114229 BG325002 AW087846 BQ678567

BM477888 BE276967 X04828 AA621030 AW250669 BE300695 BE410840 BF527916

AA156845 AW403988 BQ022154 BI193867 BG398505 CD366478 BF856412 BG388454

AI439572 AU137211 BU554079 H26819 AU145880 BG770370 BM978619 BF313294

BQ270288 BX397984 BI031071 BF884813 BG744761 N25944 AW577323 BF797826

BE857408 AA355122 BX398332 BG424492 AI911924 BP360722 BE909209 H98929

AA022566 BX397873 AV703446 BF341589 BF836727 BX458650 AA886787 AI082060

AW192845 BQ335804 BE775101 BE221562 AA143701 AL539320 AA435574 AW404082

AL575393 BE707035 AA318336 AI560496 AA301617 BQ680588 AW402459 AI953918

AU128300 BG702829 BE840208 BI027706 AI749299 BG900647 BF685510 BF026307

BQ694570 AW403614 AI866578 BG472705 BI027000 AA043024 CA311070 AL134315

BI198079 BM996772 BI222647 BG256517 BG703999 H09782 AI051277 AW401914

AA427508 CA443140 BG478725 CB164390 BE561870 AA346062 AA587611 CD613958

AI032191 AA825639 AI289140 BI024774 BX439782 AW675824 BG419493 CB528306

BG754295 AI077914 AA339313 AA310519 BE391528 AW083657 CD742909 AW103382

BF445258 BU070356 BQ071309 AW974240 BG419218 BE728009 BE260131 BE301141

BM991341 BF894583 BF926143 BI024854 BX360799 CA311706 BF884822 AW405532

BE613127 BI032169 BI027613 BQ335529 BG339225 BE895895 BF892200 AW005698

BG341977 AI827336 AA402372 BU595766 BF849659 BE840214 AA503704 AJ714329

AA775047 BQ335302 BF725063 BG424908 BI026511 BX373447 BI025366 BE221576

AI095262 AA426340 BG898278 AI033446 BE387519 BP337283 BE674704 BQ335797

BG766650 AA825168 AU123366 BQ128084 CD108083 BE730573 AI799660 BE164960

BI029569 BI027685 AW470978 BF026512 BF088230 AA742880 AL538224 BG252859

AI925052 BE301333 AL581923 BF972392 AA463242 BE277367 AA150566 CA442155

BF982283 BI032182 BF315848 AA302304 BE165004 BF744305 BQ478541 AU147941

AA834118 AA770230 BI030991 AY677118 BU553684 BM998902 BI024773 D55766

BG925632 AI445986 BM923124 BF027510 BX400044 AW581572 AI925309 BE273674

BP382802 BG315486 AA042942 BE264522 BI026522 BF924628 AW470187 BI026903

AW339153 BG421631 H98930 AL539047 BF342245 BX439496 AA507944 BE743610

BF745941 AA947697 BE049521 BG825204 BE812166 R55009 J03004 AA570039

AL589214 BF976286 AV724507 AW029602 BQ682876 BF746380 BI063057 N53884

BG027779 BI029527 CB053759 BI029917 BG340425 W30915 BE931522 BF896968

BQ329313 AA758175 N71969 BI026515 BE075103 BF359980 BG272345 BF822028

BI497152 BQ683228 BI032195 BM988930 BM544820 AA974549 AI479427 BF754433

BM990414 AA744927 AA814850 AA936741 AI274934 AA235314 BE164975 R48501

R55147 BG009219 AA747263 BE799201 AW467693 BQ213254 BE261580 BF903297

AI808948 BE892978 AA426292 BG001581 BE620624 BF924450 AI247091 BE812436

BF907558 BG469929 CK823726 AL569010 N41058 AI554724 BX460269 R79747

BM685542 AL542150 T89908 BF907550 BI032168 BI052732 BQ922937 BX337249

BF901562 BG955580 AI831822 BF992182 BE703188 AW382970 AI571771 BM969827

AW733133 AW364589 AI222802 AI609037 BF971682 BG001603 AW401925 AW875257

CN481111 AU077008 W95243 BI031613 N79620 N99974 BF238271 BF892878

BE274029 T50186 BI024858 AL570278 BM911400 BF882153 AW834751 BF907626

BG469553 CA434927 BG961464 BI820895 AW177533 AU147223 AA377330 BF991994

BI226819 AI749027 AL562077 AW972131 BE873631 AI202278 BF888239 BF746715

BM705197 BF851261 F32885 BI024844 CA418909 BI025356 M78077 AL567638

BF888075 BI005481 BX335983 BU185240 N22803 T83509 BG924312 W57705

BF381319 AA492523 BI015034 AI298706 AA054711 AI004907 BE300583 AW402537

BE840018 BF745946 BF856543 BM471553 BQ335341 BE931519 CD613962 BI830676

BE932761 AW384366 BF930530 BF381314 AL549484 AA082081 BI767768 BF941022

BI523643 AA649233 BF746381 W30912 BM806165 BF340952 AW294467 BF341900

BE745340 BE843342 N63188 BF898515 BG315289 BE906351 BI003688 AW402290

AI582580 BF888118 BE843754 BE867750 AA832370 AI864159 AA877195 AI869387

BF891833 BQ336024 BF746477 BQ375709 AA976611 AI933609 AA046537 BF991900

BF888184 BF747004 BE075156 AL571766 AW382968 AA263075 AA302582 AA844391

AW403078 BI027814 BF858473 BG014797 BG982795 BG988464 BF381301 BF896970

AW608655 AA865809 BF754442 BF907556 BF310395 BU179827 BF868873 BE964910

BF951533 BF991986 BG471840 BQ676921 R91731 BF987808 BF746475 BF826501

BF746470 BF857606 AA331038 BF892321 BI024501 BE764284 BG421317 BX379860

BF754430 AI125123 BF745943 BF894102 BF744306 BF746471 AW608678 BF907560

AL537371 BF907522 BF733224 BF746989 BI021065 BX423516 BE843756 BI192848

BF962637 BF894232 AA996268 AW385989 BF907539 BF745922 CB053758 BI028416

CD613963 AW177010 BU190333 BG822093 BF888004 BF127475 AW577115 BG479921

BX412168 BI602933 BF746476 BX454546 N99701 BF907620 BQ335913 BQ057235

BF907601 BF381337 BU556720 BF746466 BQ213091 AA284200 BF746468 BG477040

C03696 BQ371687 BG013416 BF745938 BF907602 BF879473 BG003437 BF799675

BQ959314 BF907544 BF745927 H26931 AA737483 CA443160 BF888183 BF745940

BF888126 BQ304757 BF746469 BF878273 BQ677899 BG271528 T54397 AW380135

BQ336066 BQ366246 BF935330 AI540349 BE077286 BI029510 BU540381 AA146751

BF746991 BQ379612 BE768405 BF933759 BF745932 BF744293 BF745928 BF746472

BF026011 BU959910 BE707106 BQ379547 AI885088 BI030904 U46292 BF933594

BQ375737 BQ329334 BF381303 BE255372 BI024736 D53047 BG987912 BE768404

AA618189 BF381322 BI061786 BF907526 T28912 BG002168 BF933766 BF764751

AA531365 BQ379171 BQ379181 BF907546 BE907698 BP343982 BF746370 BQ898461

BQ379189 BI024776 AW498834 BQ335783 BQ379175 AL569685 BG686900 AV699896

BF744312 BP338515 BQ681167 T54288 CD639897 BE786630 AA878937 BQ676813

BF746453 BM913269 BI024887 BF888262 CF264739

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e	·
SP1:					-		-		-		-		-		-		-		-								-														-
SP2:															-		-		-		-						-														-
SP3:					-		-		-		-		-		-		-		-		-						-														-
SP4:									-		-		-		-		-		-		-						-														-
SP5:															-		-		-		-		-				-														-

ExUns:	15f
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for GNAI2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNAI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTATGGAA

About this image

GNAI2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Anatomical compartment

Positive expression

In-situ hybridization

Brain

Anatomical compartment

Medulla Oblongata

Positive expression

In-situ hybridization

Brain

Anatomical compartment

Diencephalic Ventricular Zone

Positive expression

In-situ hybridization

Neural Tube

Anatomical compartment

Presumptive Spinal Cord

Positive expression

In-situ hybridization

Spinal Cord

Expression:

Positive

Negative

cell-identifying gene

Selective marker

Experimental details:

Curated

High-throughput

Microarrays

In-situ hybridization

See GNAI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNAI2

SOURCE GeneReport for Unigene cluster: Hs.77269

SABiosciences Expression via Pathway-Focused PCR Arrays including GNAI2:

Tight Junctions in human mouse rat

Multiple Sclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNAI2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNAI2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAI2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNAI2 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNAI2¹	guanine nucleotide binding protein (G protein), alpha more	87.32(n) 95.21(a)		396367 NM_205402.1 NP_990733.1
lizard (Anolis carolinensis)	Reptilia	GNAI2⁶	--	95(a)	1 ↔ 1	2(148689937-148767736)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21512²	Xenopus laevis guanine nucleotide-binding protein Gi more	83.72(n)		AF086606.1
zebrafish (Danio rerio)	Actinopterygii	wufi21e06²	wufi21e06	82.55(n)		327650 BC049343.1
fruit fly (Drosophila melanogaster)	Insecta	G-ialpha65A³	G-protein coupled receptor protein signaling pathway more	76(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	goa-1³	guanine nucleotide-binding protein	68(a) (best of 14)		I(7530272-7533917) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GPA1¹	Gpa1p	53.61(n) 48.49(a)		856394 NP_011868.1
thale cress (Arabidopsis thaliana)	eudicotyledons	XLG1⁶ XLG2⁶ (see all 4)	extra-large GTP-binding protein 2 (see all 4)	9(a) 8(a) (see all 4)	many ↔ many many ↔ many (see all 4)	2(9995478-9999122) 4(16441179-16445005)
rice (Oryza sativa)	Liliopsida	-- XA7⁶ (see all 5)	G-protein alpha subunit, putative, expressed (see all 5)	9(a) 29(a) (see all 5)	many ↔ many many ↔ many (see all 5)	12(24838937-24843804) 5(15552385-15556024)

ENSEMBL Gene Tree for GNAI2 (if available)
TreeFam Gene Tree for GNAI2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNAI2 gene

GNAQ² GNA14² GNA11² GNAI3² GNAT2² GNA13² GNAT3² GNAT1²

GNA15² GNA12² GNAZ² GNAI1² GNAO1²

18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries: GNAI2_HUMAN (see all proteins):

GNAI3 GNAI1 GNAT3 GNAT2 DKFZp686O0962 GNAT1

GNAZ GNAO1 GNA11 GNA14 GNAQ GNA12

GNA13 GNAL GNA15 GNAS GSA WUGSC

GNAI2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GNAI2
PGOHUM00000238547 PGOHUM00000239685

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137853226^1,2	C	other	82185941(+)	`GGACCC/G/TGCGTA`	6	R G C	mis¹		0	--	--	--	--
rs149118451^1,2		--	50271665(+)	`GCTAAC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs144864307^1,2		--	50271714(+)	`GTCTCC/GATCTC`	1	--	us2k¹		0	--	--	--	--
rs138713099^1,2		--	50271743(+)	`GCCTCA/GGCCTC`	1	--	us2k¹		0	--	--	--	--
rs140339047^1,2		--	50271778(+)	`GCCACC/TGTGCC`	1	--	us2k¹		0	--	--	--	--
rs145401213^1,2		--	50271868(+)	`AACCTC/GCGCCT`	1	--	us2k¹		0	--	--	--	--
rs192402071^1,2		--	50271918(+)	`AGCTGC/GGATTA`	1	--	us2k¹		0	--	--	--	--
rs147427338^1,2		--	50271933(+)	`TGCCCA/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs148327666^1,2		--	50272075(+)	`CAACCA/GTGCCC`	1	--	us2k¹		0	--	--	--	--
rs115409427^1,2	F,	--	50272107(+)	`TCTAAG/AGAAGG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GNAI2
5 CNVs: 30176 4335 3429 53228 4336
Human Gene Mutation Database (HGMD): GNAI2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNAI2

DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNAI2 for disorders           About GeneDecksing

OMIM gene information: 139360
OMIM disorders: 192605
20/26 diseases for GNAI2 (see all 26):    About MalaCards

ventricular tachycardia, idiopathic ventricular tachycardia high blood pressure functioning pituitary adenoma

olivopontocerebellar atrophy pituitary adenoma noonan syndrome insulin resistance

fainting squamous cell carcinoma adenoma chagas disease

trypanosomiasis toxoplasmosis pertussis pharyngitis

hypertension neuroblastoma schizophrenia adenocarcinoma

Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

Export disorders for GNAI2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNAI2 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with GNAI2)

Utopia: connect your pdf to the dynamic
world of online information

Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)^{1, 2, 3} Didsbury J.R.... Snyderman R. (1987)
Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)^{1, 2} Lopez-Aranda M.F.... Khan Z.U. (2007)
Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)^{1, 2} Cho H. and Kehrl J.H. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)^{1, 2} Komatsuzaki K.... Kinane T.B. (2002)
Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PubMed id 1733849)^{1, 3} Magovcevic I....Morton C.C. (1992)
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)^{1, 2} Itoh H.... Kaziro Y. (1988)
Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. (PubMed id 2837412)^{1, 2} Weinstein L.S.... Carter A.D. (1988)
A small multigene family encodes Gi signal-transduction proteins. (PubMed id 3120178)^{1, 2} Beals C.R.... Perlmutter R.M. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2771	HGNC: 4385	AceView: GNAI2	Ensembl:ENSG00000114353	euGenes: HUgn2771
ECgene: GNAI2	Kegg: 2771	H-InvDB: GNAI2

(According to HUGE)
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--

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GNAI2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GNAI2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GNAI2 gene
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Patent Information for GNAI2 gene:
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