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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAI2 Gene

protein-coding   GIFtS: 69
GCID: GC03P050263

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...


(Previous symbol: GNAI2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 21 2
     H_LUCA15.12
GNAI2B1 2 3 5     H_LUCA16.12
GTP-Binding Regulatory Protein Gi Alpha-2 Chain1 2     Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-22
Adenylate Cyclase-Inhibiting G Alpha Protein2 3     Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit2
GIP2 5     

External Ids:    HGNC: 43851   Entrez Gene: 27712   Ensembl: ENSG000001143537   OMIM: 1393605   UniProtKB: P048993   

Export aliases for GNAI2 gene to outside databases

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232 GC03P050239


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNAI2 Gene:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The
encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of
adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for GNAI2 Gene: 
GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) is a protein-coding gene. Diseases associated with GNAI2 include ventricular tachycardia, idiopathic, and functioning pituitary adenoma, and among its related super-pathways are G-protein mediated events and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
intracellular pool

summary for GNAI2 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAI2 gene promoter:
         SRF   CHOP-10   GR   Sp1   SRF (504 AA)   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNAI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050263:  view genomic region     (about GC identifiers)

Start:
50,263,724 bp from pter      End:
50,296,787 bp from pter
Size:
33,064 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-2  
Size: 355 amino acids; 40451 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with
UNC5B
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell
membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow
and/or the midbody
Secondary accessions: B4DYA0 Q6B6N3 Q8IZ71
Alternative splicing: 4 isoforms:  P04899-1   P04899-2   P04899-3   P04899-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GNAI2: NX_P04899

Explore proteomics data for GNAI2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04899

  • GNAI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNAI2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1  

    ENSEMBL proteins: 
     ENSP00000406871   ENSP00000406065   ENSP00000312999   ENSP00000394321   ENSP00000395736  
     ENSP00000406369   ENSP00000266027   ENSP00000444360  
    Reactome Protein details: P04899
    Human Recombinant Protein Products for GNAI2: 
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    Novus Biologicals GNAI2 Proteins
    Novus Biologicals GNAI2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GNAI2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17635935
    GO:0005813centrosome IDA17635935
    GO:0005829cytosol IEA--
    GO:0005834heterotrimeric G-protein complex IBA--

    GNAI2 for ontologies           About GeneDecksing



    GNAI2 Antibody Products: 
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    Assay Products for GNAI2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P04899

    ProtoNet protein and cluster: P04899

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    GNAI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division
    Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an
    intracellular pool

         Genatlas biochemistry entry for GNAI2:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    GNAI2 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gnai2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton  tumorigenesis 

    GNAI2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GNAI2: Gnai2tm1Lbi Gnai2tm1Rmm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNAI2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNAI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAI2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAI2 

    miRNA
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    miRTarBase miRNAs that target GNAI2:
    hsa-mir-30a (MIRT005181), hsa-mir-30d (MIRT003274)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNAI2
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI2 (see all 68):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-632 hsa-miR-578 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidGNAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of GNAI2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNAI2 About   (see all 81)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    4Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    5Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/23 EMD Millipore Pathways for GNAI2 (see all 23)
        Chemotaxis CXCR4 signaling pathway
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Integrin inside-out signaling
    Development G-Proteins mediated regulation MARK-ERK signaling

    5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI2 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    5/25 GeneGo (Thomson Reuters) Pathways for GNAI2 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/13 BioSystems Pathways for GNAI2 (see all 13)
        G Protein Signaling Pathways
    Signal Transduction of S1P Receptor
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway
    CXCR3-mediated signaling events

    5/24        Reactome Pathways for GNAI2 (see all 24)
        Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion
    Neuronal System
    Opioid Signalling

    3 PharmGKB Pathways for GNAI2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/23         Kegg Pathways  (Kegg details for GNAI2) (see all 23):
        Chemokine signaling pathway
    Axon guidance
    Tight junction
    Gap junction
    Leukocyte transendothelial migration


    GNAI2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/351 Interacting proteins for GNAI2 (P048991, 2, 3 ENSP000003129994) via UniProtKB, MINT, STRING, and/or I2D (see all 351)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF2P198782, 3, ENSP000003565054MINT-7135264 MINT-7135250 MINT-7135281 MINT-7135162 I2D: score=1 STRING: ENSP00000356505
    NCF1P145982, 3, ENSP000002894734MINT-7135281 MINT-7135190 MINT-7135171 I2D: score=1 STRING: ENSP00000289473
    MAP3K3Q997592, 3, ENSP000003549274MINT-48437 I2D: score=2 STRING: ENSP00000354927
    GNB1P628732, 3, ENSP000003678724MINT-7135221 I2D: score=1 STRING: ENSP00000367872
    HSP90AB1P082382, 3MINT-72645 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001973adenosine receptor signaling pathway IBA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS7961880
    GO:0007186G-protein coupled receptor signaling pathway TAS8587610

    GNAI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNAI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNAI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNAI2 gene (6 alternative transcripts): 
    NM_001166425.1  NM_001282617.1  NM_001282618.1  NM_001282619.1  NM_001282620.1  NM_002070.3  

    Unigene Cluster for GNAI2:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
    Hs.77269  [show with all ESTs]
    Unigene Representative Sequence: AK126708
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422163(uc003cyo.1 uc003cyp.1) ENST00000446079 ENST00000491100
    ENST00000480090 ENST00000313601(uc003cyq.1 uc011bdn.2) ENST00000441156(uc010hlg.1)
    ENST00000440628 ENST00000451956 ENST00000490122(uc003cyr.1) ENST00000468422
    ENST00000492383 ENST00000266027 ENST00000536647
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNAI2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAI2

    Additional mRNA sequence: 

    AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1 
    AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 J03004.1 X04828.1 

    24/42 DOTS entries (see all 42):

    DT.100680604  DT.97768608  DT.75112974  DT.99968212  DT.91784324  DT.97860778  DT.100680607  DT.100057602 
    DT.95357437  DT.97800888  DT.100059846  DT.100862119  DT.91784320  DT.100059845  DT.120873963  DT.100680601 
    DT.95214674  DT.100648169  DT.100680617  DT.120873971  DT.95185336  DT.120874020  DT.100042317  DT.100859294 

    1325 AceView cDNA sequences (see top 24):

    BU626280 AI824708 CD613961 CR604433 CA449568 BI032154 AA376085 AL534767 
    BC014627 BU501565 BF726024 AI631364 BU501163 M78045 AI278009 AW062609 
    BU543734 BM673245 AI863251 BE764177 AK096595 CF272190 BF969404 BU849534 
    BQ128348 BM987426 BM809344 BE257810 BI019079 AI051124 BQ182072 BM510749 
    BG758275 AU134067 CA396030 BF343350 BQ889109 AY555145 CD515989 BQ063369 
    CD557583 AW316639 AI066694 CD106402 AA826069 BQ891630 BG397573 BM811065 
    BM473715 BQ017223 BI669522 BG177488 AI810594 BU845146 AA156673 BU730850 
    AW613283 CA393116 BI758230 BM667974 BI855804 CD244774 BE795903 AW518417 
    BG056071 AI688385 AI634954 AA331041 BQ009020 BM554074 CA392435 AI346142 
    BG744096 AI272776 BQ478294 CR603761 BU527051 BQ924802 CA393856 BM916401 
    BQ680464 CR606737 BG925946 BC012138 BQ953533 BG036593 BQ888281 BQ640314 
    BM709035 BF931274 BU190649 BQ895963 BU557064 BQ682705 BG755590 BQ277773 
    BQ642357 BE744409 BE208389 BQ008949 AI718605 BQ446553 BM910681 BP375621 
    BM423419 BM662533 BQ772092 AI288697 BE257887 BU153196 BX342158 BQ677035 
    AW328616 BU528506 AL522235 BX438782 BQ229993 NM_002070 AL589215 H42978 
    BX421325 BM710071 BM554824 BU527197 AL538576 BU196095 BX475849 BQ641270 
    BU732495 BE741703 CA416342 CB161952 BQ955180 BQ773565 BE620085 BU183568 
    AA352263 AI253532 CD515225 AW006628 BU689061 BI226311 BQ718640 BG768352 
    AI654458 BG014000 BU190630 AI497940 BU188569 BX365050 CA975994 CR599468 
    BE879537 BQ679336 BQ893578 BQ233260 CR610539 BG013947 BU632644 BQ924793 
    BQ677998 BE302918 AI284196 AI758978 BM836663 BQ441013 BM708555 AW069760 
    BQ708297 AL048207 BU845251 CR609921 AI263362 AI364340 CD370282 AI086922 
    BM707077 AI051198 BE274665 AK096299 BG257499 BQ882379 AI302543 AI301376 
    BU150744 BG830529 BE764215 AI863250 BQ052858 BQ676408 BQ216760 BQ772605 
    BG165758 CR593068 CB155184 H09869 BU188098 AI754695 BE906978 CA445804 
    BQ943631 CK823725 CB140221 AA357896 BE544580 AI860738 BQ775600 BE047985 
    BM914867 BQ927770 BU856128 BG010831 BG398309 AW628068 BM663450 BQ436514 
    CA417048 BU158574 BQ422956 AI753997 BC016995 BE047986 BQ899266 BQ677700 
    BQ421415 AK126708 AW592365 BQ680845 CD367585 BU629898 BG119048 CR618994 
    CD742775 BQ016684 AF493906 AI051636 BM917082 AW467255 BP341236 AI745677 
    BQ181203 BU194908 BF969380 BQ438820 BI669179 BX462671 R65785 BQ641548 
    BM424075 BM671231 BM510995 W95126 AW008068 N90833 BQ673193 AI818517 
    BG437182 AW070661 CB565939 BE267693 BE464812 CA442212 BE166176 AI566302 
    AW673500 BG706293 R73791 AW473399 BG421451 BX427731 BE745787 BF974634 
    AI203552 BG741443 AL551940 BG748111 BU845773 BQ231358 AW168703 AI678726 
    AI421817 R79746 AK055574 BX412273 BX333895 BE886968 BF966980 BG326706 
    BE513827 BG419509 BF685795 BU617504 BX356501 BG749994 AW195251 BM707314 
    BX337967 CB146196 BG700356 BX337250 BF924453 BX380187 BX455957 BM908033 
    BX439320 BX447699 CR456783 BE251585 BX415242 BF972918 BQ645763 BQ025625 
    BG120130 BE612558 AL572075 BG829627 BE303019 CF131670 BX427732 AL542151 
    AL040479 BF724537 BG708979 CD366959 BX434229 AL544037 BU155150 AI632039 
    BG770219 BF966098 BU556898 AI086553 BM453026 AI074591 CA446117 BP381420 
    AW192103 BF799505 AK131062 AU119572 BI223125 AA393511 BG705663 BE878546 
    BX426451 AA868336 BG034830 BX354496 AL539321 BI457934 N63945 T89634 
    BM424269 AA788707 AL560481 AI619812 BG259153 BI822447 BU156759 BI458337 
    AW934885 AA604809 AU121736 BQ710882 CA443560 BQ071241 AA463243 BG472088 
    BI758631 BI596294 BE764169 AU138381 BQ676398 BI260075 BG028953 BG752074 
    BQ689245 BF924620 BQ003529 BG706941 BE884332 BV178757 AW841412 BX390790 
    BM558784 BX397985 AW610091 BX101230 BF688951 BX356500 AL572705 AA071330 
    BG763313 BF973583 AI114629 BG684765 BF206239 BF238048 BE785513 BG912177 
    BG754895 BQ641751 BE905240 BI596562 BE388618 BM758142 R65882 BU165695 
    BG437180 BG926076 BQ677862 BG714915 AI214346 BG775195 BG911310 CA413098 
    F24983 BF969526 BE388398 BQ213416 BQ050987 BM805599 AU133764 AA352548 
    AI199372 BE768854 AA312561 AI652206 BM996695 BM800958 BF688728 AI371359 
    BX439360 BX338239 BU855766 BQ004592 AA641164 BI117598 BG753237 BU753808 
    AL538225 BE907003 BG469608 BQ710188 BM808625 BG337479 BG438096 BX397874 
    AA426222 CA442956 BM470078 BE390122 BE736750 CN483896 BG758289 BG056784 
    R73790 BE312531 BE379179 AI879911 AI865293 BQ649602 BX337966 BM045978 
    AW997307 AA720666 BQ183030 BE613549 BG283523 BE296368 BE877023 AW084018 
    AI554363 BM832400 AL567386 BI826133 BE018931 BM980072 BG424931 BE905426 
    AI921342 BG678190 BM711629 BI196801 CA448305 BM809516 AL541652 BG328284 
    BU689008 BM007873 BG249901 AW470200 BG325570 BE743458 BG116501 BI335746 
    BG706694 CD613960 BX419817 BE386880 BI004068 BG419629 F30187 BE394699 
    BE388667 AI719793 BE743897 BG424150 BX419047 BG326289 BQ006061 AU121403 
    BI049510 BQ772948 CA425455 BI756299 BE882854 BU859205 BI024771 AI735650 
    BM691477 AU122343 BF841922 CD613959 BG477289 AI817579 BM757843 AI356113 
    T50047 BI603556 BM083882 BM751249 AL537372 BQ268343 AA554351 BE885091 
    CD246097 BE513816 CA442174 BG829756 BQ787364 BG341509 BU172209 BG679788 
    BM554480 BG425220 BM808944 AI936050 BQ641884 BF792226 AA340712 BG036595 
    BU178808 BI667189 AU139927 BG749009 BI192553 BG326621 AW339637 BI049505 
    BE277381 BG424558 AA056418 BE789421 BM687845 AW410490 BQ676471 AU122479 
    BF929663 BQ233822 BU627156 BG419614 AI819620 BU617634 BM697339 BM544812 
    BG392748 BQ672264 BG179277 BQ680554 BG708610 BM970706 BG767110 BQ896789 
    BG926077 AU118196 BG575030 AL534766 AW044429 BG341557 CF142388 BX462658 
    BG750333 AL546241 AI281419 BF792483 AI042073 BI597776 BM837613 BG395861 
    AA031383 BX443316 BE740640 AI335327 BG255714 BI025386 BQ016630 BG327352 
    BG680258 BX443036 BQ055805 BG284734 BM043610 CD742618 CB305457 BE535260 
    BM007518 AL048206 BX412487 BQ959034 AI369702 AA031382 BQ932757 BG766252 
    BG745687 BQ884262 AW589869 BF961210 AA410774 AA745703 BG034282 BF724437 
    BE395455 AI373086 BU153772 AW043734 BE876724 BI032190 BG112875 BM687275 
    BE764334 BG334690 BX340460 BX420207 BQ939721 BM453390 BG830523 BI522456 
    AI784297 AL546769 AA366897 AA355122 CA311070 BG703999 AU145880 AU137211 
    BG388454 AA779111 AA318336 BX365049 BI031071 BG472705 BF856412 BG325002 
    AI193136 AW117352 AA043024 BQ678567 AW083657 BX398332 AA156845 BI024774 
    BQ694945 AL134315 BE728009 BE276967 BF313294 BG114229 BF884813 BF892220 
    AI953918 AW402459 BG256517 BQ680588 AI082060 BE561870 BG770370 BI198079 
    AI024048 AI077914 BI193867 BM477888 BU187539 BE676196 BU070356 BI027000 
    BI193219 BG478725 BM755574 CD742909 AA435574 BG424492 AW403614 BQ071309 
    BF125906 AI911924 CB528306 BX354495 AI749299 BF341589 CA407901 AV703446 
    AW239314 AW328615 BX397984 BQ270288 BQ694570 BE077451 BF836727 BE909209 
    BU608179 AA599162 AA143701 AI214255 BU157729 AI866578 AW404082 BM973082 
    BI026525 BE221562 AI367560 H09782 BE707035 H98929 AA427508 AA886787 
    AU128300 BX458650 AW103382 AL575393 BG341853 BG900647 AA398683 AW949152 
    BE728653 AA346062 AW675824 AA339313 BM810284 BP360722 T50133 BF894175 
    BG419493 BF445258 BI027706 AL539320 AI022366 N25944 BF026307 AW949139 
    BX340459 BI019085 AI289140 X04828 AA705914 AW974240 BE775101 CA443140 
    AW250669 BE256856 CB164390 N99977 CF130351 BU598659 BG419218 AL542915 
    AW518732 AW401914 AA309861 AI524057 CD366478 BX374183 AI032191 BG105543 
    H26819 AA621030 BI029584 BE271864 AI051277 BM978619 BG398505 C04973 
    AI560496 BG754295 BG702829 BX439782 AW577323 AI439572 AW403988 BE391528 
    AI678725 CD613958 BF527916 BM996772 AA825639 BE300695 BQ308314 BG758897 
    BM801249 BQ335804 BX397873 AA808565 BE857408 AA558596 AL547952 AA301617 
    AA374040 BI222647 BG110026 BG768391 BE775080 BF797826 AW087846 AA071395 
    BG758856 AW192845 AA587611 AI718822 BE410840 AA310519 BG744761 BE840208 
    BG928101 BU554079 BQ022154 BF847451 AA022566 BF685510 AA834118 BI063057 
    AW005698 D55766 AW581572 BX400044 AA426340 AA150566 AW339153 BG315486 
    BI024854 BE301141 AW470187 AW470978 BE812166 BF745941 BF982283 AU147941 
    AA770230 AJ714329 BQ478541 AA302304 BE301333 BI027613 BX373447 BF027510 
    BG341977 CA442155 BE165004 AL589214 BI024773 AW405532 CB053759 BE049521 
    BI030991 BF894583 AA570039 CD108083 BE260131 BG421631 BE895895 AL538224 
    BI027685 BE840214 BE273674 BF892200 AA775047 AI445986 BQ128084 BP382802 
    BG027779 BQ682876 BF088230 AA402372 AY677118 CA311706 BE221576 BF849659 
    BE264522 BF926143 BI032169 BI025366 BM998902 AI095262 BE387519 BP337283 
    BQ335529 BF746380 BI026903 BU595766 R55009 J03004 BF342245 BX439496 
    BG766650 BE730573 N53884 BG825204 AI799660 BF972392 AA463242 BI029569 
    AL539047 BE674704 AW029602 AA503704 AI925052 AA947697 BF976286 BF725063 
    BE164960 BF924628 BX360799 BM991341 AI827336 AI033446 BF744305 BI026522 
    BG898278 AU123366 AA742880 H98930 BF315848 BE613127 BG424908 BG339225 
    AL581923 AI925309 BU553684 AV724507 BF884822 BG925632 BI029527 AA825168 
    BE277367 BQ335302 BQ335797 AA042942 BI026511 BM923124 AA507944 BE743610 
    BF026512 BG252859 BI032182 BM969827 BG955580 AW177533 CK823726 AI274934 
    BI052732 N71969 BF822028 BG009219 BQ329313 BF754433 AW401925 AA758175 
    BF381319 BE931522 AA747263 AL542150 AA936741 BF924450 AW467693 AI831822 
    BE274029 BF746715 BF888239 AI222802 N99974 AI247091 T50186 BI024858 
    AI004907 BF971682 BF882153 BF359980 BI497152 BI226819 BG001603 BE164975 
    BU185240 BG469929 AW364589 AA744927 BE799201 BI032168 AL567638 BE892978 
    BE620624 AW382970 AI609037 BE703188 BF896968 BE075103 R79747 N22803 
    BF238271 BM705197 BI032195 AA974549 AW733133 AL569010 CA418909 BI031613 
    BF907550 AI554724 BG340425 AW972131 BQ922937 N79620 AI749027 BF851261 
    BX337249 BQ683228 W57705 AW834751 BM990414 AA814850 AL562077 T89908 
    BI029917 T83509 AA426292 BG272345 BE261580 BE873631 AI298706 AU147223 
    AA492523 BM685542 AI808948 BI024844 N41058 AI479427 AU077008 BX460269 
    AL570278 BM911400 BQ213254 AW402537 R55147 AI202278 BI025356 BI026515 
    BF907626 BF991994 BE300583 BF907558 AW875257 AA235314 BI015034 BE812436 
    BG961464 BG469553 BX335983 CN481111 AA054711 AA377330 BG001581 AI571771 
    BF903297 BG924312 BI005481 F32885 CA434927 BF888075 BI820895 BF901562 
    BM988930 BM544820 M78077 W95243 BF992182 BF892878 R48501 W30915 
    AW402290 BE745340 AL571766 BM471553 BI830676 AA649233 AA877195 AI933609 
    AA844391 BG315289 BF898515 BE843342 AA046537 BG014797 BF340952 BE840018 
    AW294467 BF991900 W30912 BE932761 BF858473 AA082081 AA302582 BI523643 
    AA976611 AI582580 BF341900 BF941022 BF930530 BQ336024 BF381314 BF746381 
    AI869387 BF745946 BE843754 BF747004 BF856543 BM806165 BI003688 BQ375709 
    AA263075 AA832370 N63188 BE906351 BF888118 BF891833 CD613962 BF746477 
    AI864159 AW382968 AL549484 AW403078 BI027814 BE075156 BF888184 AW384366 
    BE867750 BQ335341 BI767768 BE931519 BF746468 BF907544 BF746470 BF754442 
    BF888004 BQ371687 AA865809 BF746476 BG421317 BE843756 CD613963 BF907602 
    BF991986 BF381337 AW608655 BF746471 BF127475 BI024501 BF894232 BF381301 
    BF894102 BF826501 R91731 BF896970 BI602933 BF746989 BF907522 BF746475 
    BF754430 BF879473 BU556720 CB053758 BF951533 BF868873 BF745938 BG013416 
    BF907539 BF907620 BQ676921 BG471840 BQ213091 BI021065 BU190333 BG822093 
    BI028416 AW577115 AW608678 BF744306 BF907560 BF892321 BI192848 BF799675 
    BF733224 BF907601 N99701 BE964910 BF962637 BF310395 BG003437 AI125123 
    BF746466 BX379860 AA996268 C03696 BF987808 AA331038 BQ335913 BG988464 
    BU179827 BG479921 AW177010 AA284200 BF907556 BG982795 BX454546 BX423516 
    BQ959314 AL537371 AW385989 BF745922 BX412168 BE764284 BF857606 BQ057235 
    BF745943 BG477040 BQ329334 BF746991 BU540381 T28912 BF746472 AA737483 
    BE768405 CA443160 BF907526 BG987912 BQ379171 BF764751 BQ336066 H26931 
    BQ375737 BU959910 BP343982 BI061786 BF888126 U46292 BF745928 BI030904 
    BQ379181 BE707106 BF933766 BF745940 BF381303 BF745932 BG271528 AI885088 
    BG002168 AA618189 BI029510 BE907698 BF888183 BQ366246 BQ677899 BF746469 
    AW380135 BF935330 D53047 BF933594 BF026011 AA146751 AI540349 BF745927 
    BI024736 BF744293 BE077286 BF933759 BF381322 AA531365 BE255372 T54397 
    BF907546 BQ379612 BF746370 BQ304757 BQ379547 BE768404 BF878273 BF744312 
    BQ379175 CF264739 BQ676813 BQ898461 AA878937 CD639897 BQ379189 AW498834 
    BI024776 BI024887 BF888262 BG686900 BQ681167 BP338515 BQ335783 BM913269 
    BE786630 AL569685 AV699896 T54288 BF746453 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:              -     -     -     -     -     -     -     -                       -                                         -                                 
    SP2:                                            -     -     -     -                 -                                         -                                 
    SP3:              -     -     -     -     -     -     -     -     -                 -                                         -                                 
    SP4:                          -     -     -     -     -     -     -                 -                                         -                                 
    SP5:                                            -     -     -     -     -           -                                         -                                 

    ExUns: 15f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GNAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAI2 expression in normal human tissues (normalized intensities)      GNAI2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGAA
    GNAI2 Expression
    About this image


    GNAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal cord/lateral wall/ventricular layer   

    See GNAI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAI2

    SOURCE GeneReport for Unigene cluster: Hs.77269
        SABiosciences Expression via Pathway-Focused PCR Arrays including GNAI2: 
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GNAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for GNAI2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNAI2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNAI2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNAI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNAI2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai21 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 91.74(n)1
    98.31(a)1
      9 (58.43 cM)5
    146781  NM_008138.41  NP_032164.21 
     1076141385 
    chicken
    (Gallus gallus)
    Aves GNAI21 guanine nucleotide binding protein (G protein), alpha more 87.32(n)
    95.21(a)
      396367  NM_205402.1  NP_990733.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    2(148689899-148811953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215122 Xenopus laevis guanine nucleotide-binding protein Gi more 83.72(n)    AF086606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi21e062 wufi21e06 82.55(n)   327650  BC049343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A3 G-protein coupled receptor protein
    signaling pathway more
    76(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA11 Gpa1p 53.61(n)
    48.49(a)
      856394   NP_011868.1 


    ENSEMBL Gene Tree for GNAI2 (if available)
    TreeFam Gene Tree for GNAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAI2 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNAI2 using alignment to 8 protein entries:     GNAI2_HUMAN (see all proteins):
    GNAI3    GNAI1    GNAT3    GNAT2    DKFZp686O0962    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNAL    GNA15    GNAS    GSA    WUGSC

    GNAI2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GNAI2
    PGOHUM00000238547 PGOHUM00000239685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 SNPs in GNAI2 are shown (see all 400)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378532261,2
    Cother150226052(+) GGACCC/G/TGCGTA 6 R G C mis10--------
    rs1491184511,2
    --50204022(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1448643071,2
    --50204071(+) GTCTCC/GATCTC 1 -- us2k10--------
    rs1387130991,2
    --50204100(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1403390471,2
    --50204135(+) GCCACC/TGTGCC 1 -- us2k10--------
    rs1454012131,2
    --50204225(+) AACCTC/GCGCCT 1 -- us2k10--------
    rs1924020711,2
    --50204275(+) AGCTGC/GGATTA 1 -- us2k10--------
    rs1474273381,2
    --50204290(+) TGCCCA/GCCACC 1 -- us2k10--------
    rs1483276661,2
    --50204432(+) CAACCA/GTGCCC 1 -- us2k10--------
    rs1154094271,2
    F--50204464(+) TCTAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for GNAI2 (50263724 - 50296787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for GNAI2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1008898CNV Deletion20482838
    dgv5132n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    dgv602n27CNV Loss19166990
    nsv470561CNV Loss18288195
    nsv460531CNV Loss19166990
    nsv523560CNV Loss19592680
    nsv523662CNV Loss19592680
    dgv5131n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): GNAI2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139360   
    OMIM disorders: 192605  
    20/26 diseases for GNAI2 (see all 26):    About MalaCards
    ventricular tachycardia, idiopathic    functioning pituitary adenoma    non-functioning pituitary adenoma    olivopontocerebellar atrophy
    noonan syndrome    trypanosomiasis    fainting    chagas disease
    toxoplasmosis    pituitary adenoma    pertussis    hiv type 1
    adenoma    huntington's disease    insulin resistance    neuroblastoma
    hypertension    multiple sclerosis    schizophrenia    retinitis


    GNAI2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNAI2
    Human Genome Epidemiology (HuGE) Navigator: GNAI2 (6 documents)

    Export disorders for GNAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAI2 gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with GNAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)1, 2, 3 Didsbury J.R.... Snyderman R. (1987)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    4. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)1, 4 Ruggeri R.M....CannavA^ S. (2008)
    5. Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. (PubMed id 17550964)1, 2 Lopez-Aranda M.F.... Khan Z.U. (2007)
    6. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (2007)
    7. The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (PubMed id 16565233)1, 4 Menzaghi C....Trischitta V. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2771 HGNC: 4385 AceView: GNAI2 Ensembl:ENSG00000114353 euGenes: HUgn2771
    ECgene: GNAI2 Kegg: 2771 H-InvDB: GNAI2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNAI2 gene:
    Search GeneIP for patents involving GNAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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