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GNAI2 Gene

protein-coding GIFtS: 72

GC03P050239

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GNAI2B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GIP ^¹, ², ⁵
GNAI2B ^², ³, ⁵
H_LUCA15.1 ^²
H_LUCA16.1 ^²
WUGSC:H_LUCA15.1 ^²
WUGSC:H_LUCA16.1 ^²

Descriptions
Adenylate cyclase-inhibiting G alpha protein ^³
GTP-binding regulatory protein Gi alpha-2 chain ^²
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 ^²

External Ids
HGNC: 4385¹
Entrez Gene: 2771²
UniProtKB: P04899³
Ensembl: ENSG00000114353⁷

Search outside databases for aliases for GNAI2 gene

Previous GC identifers: GC03M049690 GC03M049860 GC03P050118 GC03P050223 GC03P050232

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal

regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli

Gene Wiki entry for GNAI2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNAI2 gene

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

GNAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P050239: (about GC identifiers)

Start:	50,248,640 bp from pter
End:	50,271,790 bp from pter
Size:	23,151 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(i), alpha-2 subunit

Size: 355 amino acids; 40451 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the

guanine nucleotide binding site. Interacts with GPSM1 (By similarity). Interacts with UNC5B

Secondary accessions: Q8IZ71

Alternative splicing: 2 isoforms: P04899-1 P04899-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002061.1

ENSEMBL proteins:

ENSP00000266027 ENSP00000373231 ENSP00000312999

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (G Protein alpha Inhibitor 1+2, G protein alpha Inhibitor 2)
	Human Recombinant Proteins from Abnova (GNAI2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0045121	membrane raft	IEA	--

About this table

Antibodies for GNAI2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GNAI2
	Sigma-Aldrich Antibodies for GNAI2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (G Protein alpha Inhibitor 1+2, G protein alpha Inhibitor 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GNAI2)
	Novus Biologicals Antibodies for GNAI2

Assays for GNAI2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of GNAI2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04899

ProtoNet protein and cluster: P04899

2 Blocks protein families:

IPB001019 Alpha G-protein (transducin) signature

IPB001408 G-protein alpha subunit group I signature

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNAI2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNAI2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002070

Applied Biosystems Silencer® siRNAs for GNAI2

Sigma-Aldrich siRNA and siRNA Panels for GNAI2

Sigma-Aldrich shRNA for GNAI2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GNAI2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002070
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002070
untagged cDNA clones in CMV expression vector (see all 2): NM_002070

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002070

UniProtKB/Swiss-Prot: GNAI2_HUMAN, P04899

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal

regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli

Genatlas biochemistry entry for GNAI2:

guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 2

15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Gnai2) (see all 16 ):

	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	liver/biliary system	no phenotypic analysis	normal	respiratory system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	9637720
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	16189514
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/24 Sigma-Aldrich "Your Favorite Gene" Pathways for GNAI2 (Your Favorite Gene powered by Ingenuity) (see all 24 )

Leukocyte Extravasation Signaling
Relaxin Signaling
Thrombin Signaling
Role of NFAT in Regulation of the Immune Response
Ephrin Receptor Signaling

GeneDecks GNAI2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GNAI2

5/127 Interacting proteins for GNAI2 (P04899^{1, 2} ENSP00000312999³) via UniProtKB, MINT, and/or STRING (see all 127 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDFI	Q99750¹^,²	EBI-353997, EBI-724076 MINT-66321 EBI-353997, EBI-724076 MINT-66321
MDFI	Q99750¹^,²	EBI-353997, EBI-724076 MINT-66321 EBI-353997, EBI-724076 MINT-66321
CXCR5	P32302²	MINT-50704 MINT-50707
HSP90AB1	P08238²	MINT-72645
MAP3K3	Q99759²	MINT-48437

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	IEA	--
GO:0001973	adenosine receptor signaling pathway	IEA	--
GO:0007165	signal transduction	TAS	7961880 9637720
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling	IEA	--
GO:0007213	muscarinic acetylcholine receptor signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GNAI2

Browse Small Molecules at Sigma-Aldrich

Compounds for GNAI2 available from Tocris Bioscience

Compound	Action	CAS number
Melittin	Inhibits Gs and stimulates Gi activity	[20499-79-0]
NF 023	Selective, competitive P2X antagonist	[104869-31-0]
Mastoparan	Activates Gi and Go	[72093-21-1]
Pertussis Toxin	Catalyzes ADP-ribosylation of Gi, Go and Gt	[70323-44-3]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNAI2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNAI2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002070

Sigma-Aldrich siRNA and siRNA Panels for GNAI2

Sigma-Aldrich shRNA for GNAI2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002070

REFSEQ mRNAs for GNAI2 gene:

NM_002070.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002070

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002070
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002070
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002070

Additional cDNA sequence:

AF493906.1 AK055574.1 AK096299.1 AK096595.1 AK126708.1 AK131062.1 AK302330.1 AK304473.1

AY555145.1 AY677118.1 BC012138.1 BC014627.2 BC016995.1 CR456783.1 CR593068.1 CR599468.1

CR603761.1 CR604433.1 CR606737.1 CR609921.1 CR610539.1 CR618994.1 J03004.1 X04828.1

24/44 DOTS entries (see all 44 ):

DT.100680604 DT.97768608 DT.75112974 DT.99968212 DT.91784324 DT.97860778 DT.100680607 DT.100057602

DT.95357437 DT.97800888 DT.100862119 DT.100059846 DT.91784320 DT.100059845 DT.120873963 DT.100680601

DT.95214674 DT.120873971 DT.100648169 DT.100680617 DT.95185336 DT.120874020 DT.100042317 DT.100859294

24/1325 AceView cDNA sequences (see all 1325 ):

AU134067 BF969380 CA445804 BQ677998 BQ682705 BI019079 BQ277773 AW628068

BM473715 BE047986 BF969404 BG397573 AI634954 AW518417 BG755590 AI860738

BM707077 BE302918 CA393856 BQ772092 AA376085 BE764177 CD742775 BM987426

highest scoring ESTs for GNAI2:

AA022566 AA031383 AA042942 AA043024 AA046537 AA056418 AA071330 AA071395 AA143701 AA156673

Unigene Cluster for GNAI2:

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Hs.77269 [show with all ESTs]

Unigene Representative Sequence: AK126708

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GNAI2 (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e	·
SP1:					-		-		-		-		-		-		-		-								-														-
SP2:															-		-		-		-						-														-
SP3:					-		-		-		-		-		-		-		-		-						-														-
SP4:									-		-		-		-		-		-		-						-														-
SP5:															-		-		-		-		-				-														-

ExUns:	15f
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for GNAI2

3 Ensembl transcripts including schematic representations:

ENST00000266027 ENST00000383725 ENST00000313601

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GNAI2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNAI2

¹ / ² / ³

3 probe-sets matching GNAI2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37307_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X04828	0.80	1.00	0.91	1
201040_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002070	0.60	1.00	0.82	1
201040_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTATGGAA

SOURCE GeneReport for Unigene cluster: Hs.77269
Expression variation in blood from EXPOLDB for GNAI2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GNAI2 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNAI2¹	--	guanine nucleotide binding protein (G protein), alpha more	93.71(n) 98.59(a)	442957 NM_001003364.1 NP_001003364.1
chimpanzee (Pan troglodytes)	GNAI2¹	--	guanine nucleotide binding protein (G protein), alpha more	99.25(n) 100(a)	744773 XM_001167942.1 XP_001167942.1
cow (Bos taurus)	GNAI2¹	--	guanine nucleotide binding protein (G protein), alpha more	93.52(n) 99.44(a)	281791 XM_589440.3 XP_589440.3
rat (Rattus norvegicus)	Gnai2¹	--	guanine nucleotide binding protein (G protein), alpha more	92.49(n) 98.59(a)	81664 NM_031035.2 NP_112297.1
mouse (Mus musculus)	Gnai2^{1, 5}	9 (59.00 cM)⁵	guanine nucleotide binding protein (G protein), alpha more^{1, 5}	91.74(n)¹ 98.31(a)¹	14678¹ NM_008138.4¹ NP_032164.2¹ AI841629⁵ AK157998⁵ (see all 29)

About this table Species with no ortholog for GNAI2

ENSEMBL Gene Tree for GNAI2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GNAI2 gene

GNAZ² GNAI3² GNAI1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/108 NCBI SNPs in GNAI2 are shown (see all 108 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9311448^1,2	C,H	50248242(+)	`CGCAGA/CAGCTC`	1	--	ng5¹		4	EU EA WA	418
	rs15488^1,2	C	50271730(-)	`CATGTG/AAAAAA`	1	--	ut3¹		1	MN	184
	rs12895^1,2	C	50271478(-)	`CAGCAG/AAGGGA`	1	--	ut3¹ ese³		1	MN	184
--	rs12721535^1,2	H	50269376(+)	`TGAACC/TGCATG`	1	R/C	mis¹ ese³		5	EU EA WA	456
	rs762707^1,2	A,C,F,H	50264857(-)	`TCCTCG/AGAGTA`	1	S/S	syn¹ ese³		13	NA EA EU WA MN	896
	rs2298953^1,2	A,C,F,H,O	50262264(+)	`AGGCCT/GTTCCC`	1	--	int¹ trp³		5	EA EU WA	1858
	rs1894324^1,2	A,C,F,H	50255885(-)	`CATCTC/TGGGGC`	1	--	int¹		4	EU EA WA	400
	rs9852677^1,2	A,C,F,H	50266621(+)	`TATCTG/ATCATG`	1	--	int¹		11	EU EA WA NA	980
	rs2282751^1,2	A,C,F,H	50266789(+)	`AGCCAA/GTCCCC`	1	--	int¹		8	EU EA WA	840
	rs9830408^1,2	A,C,F,H	50269555(+)	`CCTCCA/GGAGGG`	1	--	int¹		6	EU EA WA	542

About this table

HapMap Linkage Disequilibrium images for GNAI2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139360

Human Gene Mutation Database: GNAI2
Human Genome Epidemiology Navigator: GNAI2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/87 PubMed articles for GNAI2 gene (see all 87 ):

Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (PubMed id 3100330)^{2, 3, 4} Didsbury J.R.... Snyderman R. (1987)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)^{3, 4} Komatsuzaki K.... Kinane T.B. (2002)
Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. (PubMed id 1733849)^{2, 3} Magovcevic I....Morton C.C. (1992)
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)^{3, 4} Itoh H.... Kaziro Y. (1988)
Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. (PubMed id 2837412)^{3, 4} Weinstein L.S.... Carter A.D. (1988)
A small multigene family encodes Gi signal-transduction proteins. (PubMed id 3120178)^{3, 4} Beals C.R.... Perlmutter R.M. (1987)
Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)³ So H.C....Sham P.C. (2009)
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)³ Ruggeri R.M....CannavA^ S. (2008)
The specific activation of TRPC4 by Gi protein subtype. (PubMed id 18854172)³ Jeon J.P....So I. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2771	HGNC: 4385	AceView: GNAI2	Ensembl:ENSG00000114353	euGenes: HUgn2771
ECgene: GNAI2	H-InvDB: GNAI2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GNAI2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GNAI2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GNAI2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNAI2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNAI2		Antibodies for GNAI2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GNAI2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GNAI2)
	Antibodies (GNAI2)
	Chimera RNAi (GNAI2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (G Protein alpha Inhibitor 1+2, G protein alpha Inhibitor 2)
	Antibodies (G Protein alpha Inhibitor 1+2, G protein alpha Inhibitor 2)

Search OriGene for GNAI2

Tocris compounds for GNAI2

	Drugs for GNAI2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GNAI2

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GNAI2 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for GNAI2

Summaries
for GNAI2

Genomic Location
for GNAI2

Proteins
for GNAI2

Protein Domains/
Families
for GNAI2

Gene Function
for GNAI2

Pathways & Interactions
for GNAI2

Drugs & Compounds
for GNAI2

Transcripts
for GNAI2

Expression
for GNAI2

Orthologs
for GNAI2

Paralogs
for GNAI2

SNPs/Variants
for GNAI2

Disorders & Mutations
for GNAI2

Medical News
for GNAI2

Publications
for GNAI2

Search for GNAI2

Genome Databases showing GNAI2

Other Databases showing GNAI2

Specialized Databases showing GNAI2

Licensable Technologies
for GNAI2

Services
for GNAI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNAI2 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor GNAI2

Summariesfor GNAI2

Genomic Locationfor GNAI2

Proteinsfor GNAI2

Protein Domains/Familiesfor GNAI2

Gene Functionfor GNAI2

Pathways & Interactionsfor GNAI2

Drugs & Compoundsfor GNAI2

Transcriptsfor GNAI2

Expression for GNAI2

Orthologsfor GNAI2

Paralogsfor GNAI2

SNPs/Variantsfor GNAI2

Disorders & Mutationsfor GNAI2

Medical Newsfor GNAI2

Publicationsfor GNAI2

Search for GNAI2

Genome Databases showing GNAI2

Other Databases showing GNAI2

Specialized Databases showing GNAI2

Licensable Technologiesfor GNAI2

Servicesfor GNAI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNAI2

Summaries
for GNAI2

Genomic Location
for GNAI2

Proteins
for GNAI2

Protein Domains/
Families
for GNAI2

Gene Function
for GNAI2

Pathways & Interactions
for GNAI2

Drugs & Compounds
for GNAI2

Transcripts
for GNAI2

Expression
for GNAI2

Orthologs
for GNAI2

Paralogs
for GNAI2

SNPs/Variants
for GNAI2

Disorders & Mutations
for GNAI2

Medical News
for GNAI2

Publications
for GNAI2

Licensable Technologies
for GNAI2

Services
for GNAI2