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Aliases for GNAI1 Gene

Aliases for GNAI1 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 1 2 3
  • Adenylate Cyclase-Inhibiting G Alpha Protein 3 4
  • Gi1 Protein Alpha Subunit 2 3
  • Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-1 3
  • Gi 3

External Ids for GNAI1 Gene

Summaries for GNAI1 Gene

Entrez Gene Summary for GNAI1 Gene

  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GNAI1 Gene

GNAI1 (Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 1) is a Protein Coding gene. Diseases associated with GNAI1 include pertussis. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAI1 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Tocris Summary for GNAI1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAI1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAI1 Gene

Genomics for GNAI1 Gene

Genomic Location for GNAI1 Gene

Start:
80,133,955 bp from pter
End:
80,219,409 bp from pter
Size:
85,455 bases
Orientation:
Plus strand

Genomic View for GNAI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAI1 Gene

Regulatory Elements for GNAI1 Gene

Proteins for GNAI1 Gene

  • Protein details for GNAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63096-GNAI1_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(i) subunit alpha-1
    Protein Accession:
    P63096
    Secondary Accessions:
    • A8KA88
    • B4E2V1
    • C9J3A4
    • P04898
    • P11015
    • P31871
    • Q5U074
    • Q8TAN5
    • Q9UGA4

    Protein attributes for GNAI1 Gene

    Size:
    354 amino acids
    Molecular mass:
    40361 Da
    Quaternary structure:
    • Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

    Three dimensional structures from OCA and Proteopedia for GNAI1 Gene

    Alternative splice isoforms for GNAI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNAI1 Gene

Proteomics data for GNAI1 Gene at MOPED

Post-translational modifications for GNAI1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35, Lys46, Lys92, Lys192, Lys197, Lys248, and Lys349

Other Protein References for GNAI1 Gene

No data available for DME Specific Peptides for GNAI1 Gene

Domains for GNAI1 Gene

UniProtKB/Swiss-Prot:

GNAI1_HUMAN
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.:
    • P63096
genes like me logo Genes that share domains with GNAI1: view

No data available for Gene Families for GNAI1 Gene

Function for GNAI1 Gene

Molecular function for GNAI1 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Gene Ontology (GO) - Molecular Function for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI 15537540
GO:0005525 GTP binding ISS --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAI1: view
genes like me logo Genes that share phenotypes with GNAI1: view

Animal Models for GNAI1 Gene

MGI Knock Outs for GNAI1:

miRNA for GNAI1 Gene

miRTarBase miRNAs that target GNAI1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNAI1 Gene

Localization for GNAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAI1 Gene

Nucleus. Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAI1 Gene COMPARTMENTS Subcellular localization image for GNAI1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 17635935
GO:0005765 lysosomal membrane IDA 17897319
GO:0005813 centrosome IDA 17635935
genes like me logo Genes that share ontologies with GNAI1: view

Pathways for GNAI1 Gene

genes like me logo Genes that share pathways with GNAI1: view

Gene Ontology (GO) - Biological Process for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GNAI1: view

Compounds for GNAI1 Gene

(5) Tocris Compounds for GNAI1 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(4) HMDB Compounds for GNAI1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanine
  • GUN
73-40-5
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Drugbank Compounds for GNAI1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
Tetrafluoroaluminate Ion
target

(77) Novoseek inferred chemical compound relationships for GNAI1 Gene

Compound -log(P) Hits PubMed IDs
pertussis 81 12
adenylate 75.9 57
gtp 74.9 22
forskolin 71.7 6
mastoparan 70.7 7
genes like me logo Genes that share compounds with GNAI1: view

Transcripts for GNAI1 Gene

Unigene Clusters for GNAI1 Gene

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAI1 Gene

No ASD Table

Relevant External Links for GNAI1 Gene

GeneLoc Exon Structure for
GNAI1
ECgene alternative splicing isoforms for
GNAI1

Expression for GNAI1 Gene

mRNA expression in normal human tissues for GNAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNAI1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAI1 Gene

SOURCE GeneReport for Unigene cluster for GNAI1 Gene Hs.134587

genes like me logo Genes that share expressions with GNAI1: view

Orthologs for GNAI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNAI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAI1 36
  • 99.72 (n)
  • 100 (a)
GNAI1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAI1 36
  • 93.79 (n)
  • 100 (a)
GNAI1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAI1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai1 36
  • 88.51 (n)
  • 100 (a)
Gnai1 16
Gnai1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAI1 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnai1 36
  • 88.61 (n)
  • 99.72 (a)
chicken
(Gallus gallus)
Aves GNAI1 36
  • 87.1 (n)
  • 98.02 (a)
GNAI1 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAI1 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21937 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gnai1 36
  • 83.05 (n)
  • 98.02 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
gnai1 36
  • 78.91 (n)
  • 96.89 (a)
gnai1 37
  • 97 (a)
OneToMany
gnaia 37
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005904 36
  • 66.95 (n)
  • 80.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 67.23 (n)
  • 77.97 (a)
G-ialpha65A 37
  • 78 (a)
OneToMany
Galpha73B 38
  • 35 (a)
G-ialpha65A 38
  • 77 (a)
G-oalpha47A 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea gpa-16 36
  • 62.9 (n)
  • 66.95 (a)
odr-3 38
  • 48 (a)
gpa-14 38
  • 31 (a)
gpa-6 38
  • 38 (a)
gpa-4 38
  • 60 (a)
goa-1 38
  • 69 (a)
gpa-10 38
  • 35 (a)
gpa-15 38
  • 43 (a)
gpa-8 38
  • 39 (a)
gpa-3 38
  • 50 (a)
gpa-9 38
  • 36 (a)
gpa-1 38
  • 45 (a)
gpa-7 38
  • 54 (a)
gpa-11 38
  • 40 (a)
gpa-2 38
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 39
soybean
(Glycine max)
eudicotyledons Gma.159 36
barley
(Hordeum vulgare)
Liliopsida Hv.253 36
rice
(Oryza sativa)
Liliopsida Os.5302 36
wheat
(Triticum aestivum)
Liliopsida Ta.14280 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2644 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 37
  • 83 (a)
OneToMany
Species with no ortholog for GNAI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GNAI1 Gene

ENSEMBL:
Gene Tree for GNAI1 (if available)
TreeFam:
Gene Tree for GNAI1 (if available)

Paralogs for GNAI1 Gene

Paralogs for GNAI1 Gene

genes like me logo Genes that share paralogs with GNAI1: view

Variants for GNAI1 Gene

Sequence variations from dbSNP and Humsavar for GNAI1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9244 -- 80,217,999(+) TAGAT(C/T)ATATG utr-variant-3-prime
rs719057 -- 80,159,696(-) GAACC(A/G)CAACT intron-variant
rs916905 -- 80,171,031(+) AGGTT(C/T)ATTAC intron-variant
rs998251 -- 80,142,235(-) GATAC(C/T)GATGA intron-variant
rs1013942 -- 80,140,735(+) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNAI1 Gene

Variant ID Type Subtype PubMed ID
nsv888512 CNV Loss 21882294
nsv507398 CNV Insertion 20534489

Relevant External Links for GNAI1 Gene

HapMap Linkage Disequilibrium report
GNAI1

Disorders for GNAI1 Gene

(1) MalaCards Diseases for GNAI1 Gene

Search for GNAI1 Gene in MalaCards »

(18) Novoseek inferred disease relationships for GNAI1 Gene

Disease -log(P) Hits PubMed IDs
cholera 67.4 15
thyroid adenoma 28.6 2
heart failure 23.9 4
pituitary adenoma 4.2 3
asthma 3.39 1

Relevant External Links for GNAI1

Genetic Association Database (GAD)
GNAI1
Human Genome Epidemiology (HuGE) Navigator
GNAI1
genes like me logo Genes that share disorders with GNAI1: view

No data available for UniProtKB/Swiss-Prot for GNAI1 Gene

Publications for GNAI1 Gene

  1. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PMID: 3110783) Bray P. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4
  2. CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. (PMID: 11168387) Mukhopadhyay S. … Howlett A.C. (Eur. J. Biochem. 2001) 3 23
  3. Identification of the platelet ADP receptor targeted by antithrombotic drugs. (PMID: 11196645) Hollopeter G. … Conley P.B. (Nature 2001) 3 23
  4. Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. (PMID: 15863506) Campus F. … Torti M. (J. Biol. Chem. 2005) 3 23
  5. Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion. (PMID: 17416965) Rimler A. … Zisapel N. (J. Mol. Neurosci. 2007) 3 23

Products for GNAI1 Gene

Sources for GNAI1 Gene

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