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GNAI1 Gene

protein-coding   GIFtS: 69
GCID: GC07P079763

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...

  See GNAI1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 11 2
Gi1 Protein Alpha Subunit1 2
Adenylate Cyclase-Inhibiting G Alpha Protein2 3
Gi2
Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-12

External Ids:    HGNC: 43841   Entrez Gene: 27702   Ensembl: ENSG000001279557   OMIM: 1393105   UniProtKB: P630963   

Export aliases for GNAI1 gene to outside databases

Previous GC identifers: GC07P078299 GC07P079362 GC07P079376 GC07P079408 GC07P079602 GC07P074367


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNAI1 Gene:
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and
gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other
proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded
protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for GNAI1 Gene:
GNAI1 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1) is a protein-coding gene. Diseases associated with GNAI1 include pertussis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association
of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma
membrane. May play a role in cell division

summary for GNAI1 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNAI1 gene promoter:
         TBP   p53   AP-1   ATF-2   CREB   deltaCREB   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI1 promoter sequence
   Search Chromatin IP Primers for GNAI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNAI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21-q22

GNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P079763:  view genomic region     (about GC identifiers)

Start:
79,763,271 bp from pter      End:
79,848,725 bp from pter
Size:
85,455 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 79,095,649-79,180,223     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-1  
Size: 354 amino acids; 40361 Da
Subunit: Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with
RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with
RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and
gamma. The alpha chain contains the guanine nucleotide binding site
Selected PDB 3D structures from and Proteopedia for GNAI1 (see all 14):
1KJY (3D)        1Y3A (3D)        2G83 (3D)        2GTP (3D)        2IK8 (3D)        2OM2 (3D)    
Secondary accessions: A8KA88 B4E2V1 C9J3A4 P04898 P11015 P31871 Q5U074 Q8TAN5 Q9UGA4
Alternative splicing: 2 isoforms:  P63096-1   P63096-2   

Explore the universe of human proteins at neXtProt for GNAI1: NX_P63096

Explore proteomics data for GNAI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys46, Lys92, Lys192, Lys197, Lys248, Lys349
  • Modification sites at PhosphoSitePlus

  • See GNAI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243343.1  NP_002060.4  

    ENSEMBL proteins: 
     ENSP00000391439   ENSP00000343027   ENSP00000389435   ENSP00000410572   ENSP00000388347  
    Reactome Protein details: P63096

    GNAI1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GNAI1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNAI1 

     
    antibodies-online proteins for GNAI1 (12 products) 

     
    antibodies-online peptides for GNAI1

    GNAI1 Antibody Products:

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    antibodies-online antibodies for GNAI1 (29 products) 

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    Search eBioscience for ELISAs for GNAI1 
    antibodies-online kits for GNAI1 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P63096

    ProtoNet protein and cluster: P63096

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Find genes that share domains with GNAI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI1_HUMAN, P63096
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association
    of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma
    membrane. May play a role in cell division

         Genatlas biochemistry entry for GNAI1:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI15537540
    GO:0005525GTP binding ISS--
    GO:0019001guanyl nucleotide binding ----
         
    Find genes that share ontologies with GNAI1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GNAI1:
     Decreased cell number and incr  Increased cell number in G1, s  Increased gamma-H2AX phosphory  Increased homologous recombina 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnai1):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 
     skeleton 

    Find genes that share phenotypes with GNAI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gnai1tm1Drs for GNAI1

       genOway: Develop your customized and physiologically relevant rodent model for GNAI1

    miRNA
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    miRTarBase miRNAs that target GNAI1:
    hsa-mir-186-5p (MIRT021108), hsa-mir-1 (MIRT023552)

    Block miRNA regulation of human, mouse, rat GNAI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNAI1 (see all 15):
    hsa-miR-323-3p hsa-miR-320a hsa-miR-448 hsa-miR-485-3p hsa-miR-320d hsa-miR-548e hsa-miR-4282 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNAI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GNAI1
    Predesigned siRNA for gene silencing in human, mouse, rat GNAI1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GNAI1 (NM_002069)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNAI1_HUMAN, P63096: Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule
    organizing center, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A
    and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells,
    but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17635935
    GO:0005765lysosomal membrane IDA17897319
    GO:0005794Golgi apparatus ----

    Find genes that share ontologies with GNAI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNAI1 About   (see all 85)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    ADP signalling through P2Y purinoceptor 120.74
    G alpha (z) signalling events0.47
    G-protein activation0.74
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    4Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    5G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44


    Find genes that share SuperPaths with GNAI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNAI1 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for GNAI1
        Ca, cAMP and Lipid Signaling

    Selected GeneGo (Thomson Reuters) Pathways for GNAI1 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for GNAI1 (see all 15)
        Signal Transduction of S1P Receptor
    G Protein Signaling Pathways
    Nicotine Activity on Dopaminergic Neurons
    Calcium Regulation in the Cardiac Cell
    Corticotropin-releasing hormone

    Selected Reactome Pathways for GNAI1 (see all 9)
        Regulation of insulin secretion
    G alpha (z) signalling events
    G-protein activation
    Adenylate cyclase inhibitory pathway
    PLC beta mediated events

    4 PharmGKB Pathways for GNAI1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GNAI1) (see all 27):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Adrenergic signaling in cardiomyocytes
    Axon guidance
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI1: 
              Tight Junctions in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GNAI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNAI1 (P630961, 2, 3 ENSP000003430274) via UniProtKB, MINT, STRING, and/or I2D (see all 244)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135852, 3, ENSP000002183164MINT-2836319 I2D: score=1 STRING: ENSP00000218316
    MT1AP047312, 3, ENSP000002907054MINT-2836337 I2D: score=1 STRING: ENSP00000290705
    NUMA1Q149801, 3EBI-618639,EBI-521611 I2D: score=3 
    GPSM3Q9Y4H43, ENSP000003641804I2D: score=2 STRING: ENSP00000364180
    ENSG00000206314Q9Y4H43I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006906vesicle fusion ----
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ISS--
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with GNAI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for GNAI1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    4 HMDB Compounds for GNAI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    GuanineGUN (see all 26)73-40-5--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for GNAI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Tetrafluoroaluminate Ion-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for GNAI1 gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pertussis 81 12 7898487 (1), 16899767 (1), 1953712 (1), 1309343 (1) (see all 12)
    adenylate 75.9 67 2109182 (4), 8384153 (2), 8282007 (2), 2159482 (2) (see all 48)
    gtp 74.9 27 1795017 (2), 2109182 (1), 8282007 (1), 7514261 (1) (see all 21)
    forskolin 71.7 6 2109182 (1), 8282007 (1), 10930355 (1), 10410308 (1) (see all 6)
    mastoparan 70.7 7 1938104 (1), 8307108 (1), 7802684 (1), 9371843 (1) (see all 7)
    guanosine 5'-o-(3-thiotriphosphate) 69.7 1 2170379 (1)
    guanine 67.7 17 2109182 (1), 2129393 (1), 1648103 (1), 9293962 (1) (see all 17)
    cyclic amp 66.9 12 7542872 (2), 8282007 (1), 10737627 (1), 7526047 (1) (see all 10)
    isoproterenol 64.9 14 12972572 (2), 10930355 (1), 7473226 (1), 1330500 (1) (see all 10)
    cholera toxin 59.6 2 1330500 (1), 9556056 (1)



    Find genes that share compounds with GNAI1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNAI1 gene (2 alternative transcripts): 
    NM_001256414.1  NM_002069.5  

    Unigene Cluster for GNAI1:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
    Hs.134587  [show with all ESTs]
    Unigene Representative Sequence: BC026326
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442586 ENST00000490206 ENST00000351004(uc003uhb.1 uc011kgt.1)
    ENST00000418742 ENST00000457358 ENST00000447650
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GNAI1 (see all 15):
    hsa-miR-323-3p hsa-miR-320a hsa-miR-448 hsa-miR-485-3p hsa-miR-320d hsa-miR-548e hsa-miR-4282 hsa-miR-548a-3p
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      QuantiFast Probe-based Assays in human, mouse, rat GNAI1

    Additional mRNA sequence: 

    AF055013.1 AF493905.1 AK292953.1 AK304442.1 AL049933.1 BC026326.1 BT019775.1 M17219.1 

    8 DOTS entries:

    DT.116051  DT.121094745  DT.92424890  DT.92424892  DT.121094753  DT.121094757  DT.100816334  DT.92008477 

    Selected AceView cDNA sequences (see all 194):

    AL539524 AF055013 CB045322 F02356 BF509333 BU689706 BU675856 Z98491 
    CR616478 R37785 CD674623 AL712917 R37344 CA435583 NM_002069 AF493905 
    CF141281 BQ021391 H47718 CD677445 CR600756 BX502815 AL536202 BX397644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNAI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATTATGG
    GNAI1 Expression
    About this image


    GNAI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
    GNAI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNAI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134587
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNAI1: 
              Tight Junctions in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNAI1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai11 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 88.51(n)1
    100(a)1
      5 (8.16 cM)5
    146771  NM_010305.11  NP_034435.11 
     182651355 
    chicken
    (Gallus gallus)
    Aves GNAI11 guanine nucleotide binding protein (G protein), alpha more 87.1(n)
    98.02(a)
      396368  NM_205403.1  NP_990734.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI16
    guanine nucleotide binding protein (G protein), al...
    98(a)
    1 ↔ 1
    5(93360700-93387609)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.219372 X. laevis mRNA for alpha-subunit of G-protein, type more 81.5(n)    X56089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053164.12   -- 79.46(n)   393946  BC053164.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    G protein alphai subunit 65A1
    77(a)
    (best of 3)3
    67.23(n)1
    77.97(a)1
      387651  NM_058154.41  NP_477502.11 
    worm
    (Caenorhabditis elegans)
    Secernentea goa-13
    gpa-161
    guanine nucleotide-binding protein3
    gpa-161
    69(a)
    (best of 14)3
    62.9(n)1
    66.95(a)1
      I(7530272-7533917)3
    1716751  NM_058389.31  NP_490790.11 
    soybean
    (Glycine max)
    eudicotyledons Gma.1592 G.max mRNA for alpha subunit of G protein 70.16(n)    X95582.1 
    rice
    (Oryza sativa)
    Liliopsida Os.53022 Oryza sativa (japonica cultivar-group) mRNA for G protein more 71.1(n)    AB026176.1 


    ENSEMBL Gene Tree for GNAI1 (if available)
    TreeFam Gene Tree for GNAI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNAI1 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNAI22  GNA152  GNAZ2  GNAO12  
    18 SIMAP similar genes for GNAI1 using alignment to 5 protein entries:     GNAI1_HUMAN (see all proteins):
    GNAI3    GNAI2    DKFZp686O0962    GNAT2    GNAT3    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNA15    GNAL    GSA    GNAS    WUGSC

    Find genes that share paralogs with GNAI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNAI1 (see all 1748)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901565531,2
    --79762254(+) TTTAGA/GGCAGC 1 -- us2k10--------
    rs1455353091,2
    --79762305(+) CTGTTA/GTCATT 1 -- us2k10--------
    rs671582761,2
    C--79762482(+) GATGG-/AAGTA 
            
    ATGTT
    1 -- us2k10--------
    rs1160435041,2
    --79763264(+) TCTCCC/GCCGAT 2 -- us2k10--------
    rs679980141,2
    C--79763270(+) CGATT-/CGTTAC 2 -- us2k10--------
    rs27144651,2
    C,F,H--79763302(+) GCACCA/GTAGAT 2 -- us2k119Minor allele frequency- G:0.27NS EA NA WA 2340
    rs1417347901,2
    --79763310(+) GATCCA/CCTCCT 2 -- us2k10--------
    rs1814864461,2
    --79763386(+) CACGGC/TCATAA 2 -- us2k10--------
    rs1505505471,2
    --79763428(+) TGTGCA/TGCTCT 2 -- us2k10--------
    rs1863845561,2
    --79763460(+) GGAGAC/TTGGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNAI1 (79763271 - 79848725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNAI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507398CNV Insertion20534489
    nsv888512CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNAI1
    DNA2.0 Custom Variant and Variant Library Synthesis for GNAI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139310    OMIM disorders: --

    1 disease for GNAI1:    
    About MalaCards
    pertussis


    Find genes that share disorders with GNAI1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GNAI1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 67.4 17 1662135 (2), 1683639 (1), 7898487 (1), 8752494 (1) (see all 14)
    thyroid adenoma 28.6 2 1284336 (1), 16444361 (1)
    heart failure 23.9 4 7898487 (1), 1666557 (1), 1978979 (1), 16932076 (1)
    pituitary adenoma 4.2 3 9405027 (2), 16444361 (1)
    asthma 3.39 1 8752494 (1)
    glioma 2.72 1 10410308 (1)
    tumors 2.2 8 8784077 (2), 1473250 (1), 16444361 (1), 9362361 (1) (see all 5)
    cancer 0.196 1 17416965 (1)
    insulin resistance 0 2 9277377 (2)
    essential hypertension 0 1 8888689 (1)

    Genetic Association Database (GAD): GNAI1
    Human Genome Epidemiology (HuGE) Navigator: GNAI1 (4 documents)

    Export disorders for GNAI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNAI1 gene, integrated from 10 sources (see all 469):
    (articles sorted by number of sources associating them with GNAI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PubMed id 3110783)1, 2, 3 Bray P....Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (J. Cell Biol. 2007)
    5. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (PubMed id 16004878)1, 2 Johnston C.A.... Siderovski D.P. (Structure 2005)
    6. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. (PubMed id 11976690)1, 2 Kimple R.J.... Siderovski D.P. (Nature 2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2770 HGNC: 4384 AceView: GNAI1 Ensembl:ENSG00000127955 euGenes: HUgn2770
    ECgene: GNAI1 Kegg: 2770 H-InvDB: GNAI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GNAI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GNAI1 gene:
    Search GeneIP for patents involving GNAI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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