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GNAI1 Gene

protein-coding GIFtS: 66

GC07P079602

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Gi ^²

Descriptions
Adenylate cyclase-inhibiting G alpha protein ^³
Gi1 protein alpha subunit ^²
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 ^²

External Ids
HGNC: 4384¹
Entrez Gene: 2770²
UniProtKB: P63096³
Ensembl: ENSG00000127955⁷

Search outside databases for aliases for GNAI1 gene

Previous GC identifers: GC07P078299 GC07P079362 GC07P079376 GC07P079408

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GNAI1:

Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing

molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of

the G protein family have been characterized most extensively on the basis of the alpha subunit,

which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific

receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the

stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in

brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 139330) and transducin-2 (GNAT2; MIM

139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan

et al., 1986 [PubMed 3092218]; Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed

2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type

subunits of G protein; see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM

139180).[supplied by OMIM]

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal

regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli

Gene Wiki entry for GNAI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNAI1 gene

Entrez Gene cytogenetic band: 7q21 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21-q22

GNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P079602: (about GC identifiers)

Start:	79,602,076 bp from pter
End:	79,686,661 bp from pter
Size:	84,586 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 79,095,649-79,180,223

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein G(i), alpha-1 subunit

Size: 354 amino acids; 40361 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the

guanine nucleotide binding site. Interacts with GPSM1 (By similarity)

PDB structures from and Proteopedia :

1KJY (3D)

1Y3A (3D)

2EBC (3D)

2G83 (3D)

2GTP (3D)

2HLB (3D)

2IK8 (3D)

2OM2 (3D)

2PZ2 (3D)

2PZ3 (3D)

Secondary accessions: P04898 P11015 P31871 Q5U074 Q8TAN5 Q9UGA4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002060.4

ENSEMBL proteins:

ENSP00000343027

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (G Protein alpha Inhibitor 1+2, G protein alpha inhibitor 1)
	Human Recombinant Proteins from Abnova (GNAI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005834	heterotrimeric G-protein complex	TAS	3110783
GO:0005886	plasma membrane	TAS	3139448

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Antibodies for GNAI1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GNAI1
	Sigma-Aldrich Antibodies for GNAI1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (G Protein alpha Inhibitor 1+2, G protein alpha inhibitor 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GNAI1

Assays for GNAI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P63096

ProtoNet protein and cluster: P63096

2 Blocks protein families:

IPB001019 Alpha G-protein (transducin) signature

IPB001408 G-protein alpha subunit group I signature

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096

Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNAI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNAI1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002069

Applied Biosystems Silencer® siRNAs for GNAI1

Sigma-Aldrich siRNA for GNAI1

Sigma-Aldrich shRNA for GNAI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002069
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002069
untagged cDNA clone in CMV expression vector: NM_002069

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002069

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal

regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli

Genatlas biochemistry entry for GNAI1:

guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gnai1):

behavior/neurological

immune system

nervous system

no phenotypic analysis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	2834384
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	15537540
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/24 Sigma-Aldrich "Your Favorite Gene" Pathways for GNAI1 (Your Favorite Gene powered by Ingenuity) (see all 24 )

Corticotropin Releasing Hormone Signaling
Cardiac Hypertrophy Signaling
CXCR4 Signaling
Role of NFAT in Regulation of the Immune Response
G-Protein Coupled Receptor Signaling

GeneDecks GNAI1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GNAI1

4 Interacting proteins for GNAI1 (P63096^{1, 2}) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
GPSM2 P81274¹ EBI-618639, EBI-618655
NUMA1 Q14980¹ EBI-618639, EBI-521611
GPR50 Q13585² MINT-2836319
MT1A P04731² MINT-2836337
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2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor protein signaling pathway IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for GNAI1

Browse Small Molecules at Sigma-Aldrich

Compounds for GNAI1 available from Tocris Bioscience

Compound	Action	CAS number
Melittin	Inhibits Gs and stimulates Gi activity	[20499-79-0]
NF 023	Selective, competitive P2X antagonist	[104869-31-0]
Mastoparan	Activates Gi and Go	[72093-21-1]
Pertussis Toxin	Catalyzes ADP-ribosylation of Gi, Go and Gt	[70323-44-3]

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10/44 Novoseek chemical compound relationships for GNAI1 gene (see all 44 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	74.97	27	1795017 (2), 2109182 (1), 8282007 (1), 7514261 (1) (see all 21)
forskolin	71.29	6	2109182 (1), 8282007 (1), 10930355 (1), 10410308 (1) (see all 6)
mastoparan	71.06	7	1938104 (1), 8307108 (1), 7802684 (1), 9371843 (1) (see all 7)
guanosine 5'-o-(3-thiotriphosphate)	69.96	1	2170379 (1)
cyclic amp	66.70	12	7542872 (2), 8282007 (1), 10737627 (1), 7526047 (1) (see all 10)
cholera toxin	59.86	2	1330500 (1), 9556056 (1)
adp	57.76	33	8200911 (3), 1935970 (3), 9651830 (2), 10544922 (2) (see all 20)
calcium	52.16	45	7930588 (2), 9405566 (2), 7514261 (1), 9530435 (1) (see all 29)
gppnhp	52.09	1	8245822 (1)
gdp	52.08	10	11862333 (3), 1795017 (2), 1938104 (1), 1732718 (1) (see all 5)

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1 PharmGKB drug compound relationship for GNAI1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
isoproterenol	FA	9363896

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNAI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNAI1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002069

Sigma-Aldrich siRNA for GNAI1

Sigma-Aldrich shRNA for GNAI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002069

REFSEQ mRNAs for GNAI1 gene:

NM_002069.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002069

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002069
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002069
                                 untagged cDNA clone in CMV expression vector: NM_002069

Additional cDNA sequence:

AF055013.1 AF493905.1 AK292953.1 AK304442.1 AL049933.1 BC026326.1 BT019775.1 CR594203.1

CR595689.1 CR600756.1 CR616478.1 CR621915.1 M17219.1

8 DOTS entries:

DT.116051 DT.121094745 DT.92008477 DT.92424890 DT.92424892 DT.100816334 DT.121094753 DT.121094757

24/194 AceView cDNA sequences (see all 194 ):

CA435583 CB045322 CB131951 AL539524 BQ021391 BU675856 R37344 AA406364

BX461211 CF141281 BM988854 U47728 N48427 BX502815 BU738955 CR594203

AL712917 AV708892 BU622732 AI367770 H47718 CD677445 CR600756 R20361

highest scoring ESTs for GNAI1:

AL049933 AA187880 AA187881 AA187885 AA187886 AA233627 AA233775 AA406364 AA406420 AA425177

Unigene Cluster for GNAI1:

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Hs.134587 [show with all ESTs]

Unigene Representative Sequence: BC026326

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000351004

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GNAI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNAI1

¹ / ² / ³

6 probe-sets matching GNAI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44001_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.01	AI982766	0.60	0.78	0.69	1
33809_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.99	AL049933	1.00	1.00	1.00	1
209576_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL049933	1.00	1.00	1.00	1
227692_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU153866	0.60	1.00	0.82	1
209576_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227692_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GNAI1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AGAATTATGG

SOURCE GeneReport for Unigene cluster: Hs.134587
Expression variation in blood from EXPOLDB for GNAI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GNAI1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNAI1¹	--	guanine nucleotide binding protein (G protein), alpha more	93.42(n) 99.06(a)	478227 XM_535402.2 XP_535402.2
chimpanzee (Pan troglodytes)	GNAI1¹	--	guanine nucleotide binding protein (G protein), alpha more	99.62(n) 100(a)	472425 XM_001159444.1 XP_001159444.1
cow (Bos taurus)	GNAI1¹	--	guanine nucleotide binding protein (G protein), alpha more	93.79(n) 100(a)	281790 NM_174324.2 NP_776749.1
rat (Rattus norvegicus)	Gnai1¹	--	guanine nucleotide binding protein (G protein), alpha more	88.61(n) 99.72(a)	25686 NM_013145.1 NP_037277.1
mouse (Mus musculus)	Gnai1^{1, 5}	5 (2.00 cM)⁵	guanine nucleotide binding protein (G protein), alpha more^{1, 5}	88.51(n)¹ 100(a)¹	14677¹ NM_010305.1¹ NP_034435.1¹ AI153412⁵ AI314276⁵ (see all 15)

About this table Species with no ortholog for GNAI1

ENSEMBL Gene Tree for GNAI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GNAI1 gene

GNAI2² GNAZ² GNAI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/431 NCBI SNPs in GNAI1 are shown (see all 431 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 179)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11767465^1,2	A,C,F,H	79686230(+)	`ACGTTA/GCTGGT`	1	--	ut3¹ ese³		8	EU EA WA	828
	rs9244^1,2	A,C,F,H	79685251(+)	`TAGATT/CATATG`	1	--	ut3¹		8	MN EU EA WA NA	746
	rs4610665^1,2	A,C,F,H	79686843(+)	`AGAATG/CCATTG`	1	--	ng3¹		7	EU EA WA NA	532
	rs4458811^1,2	A,C,F	79686903(+)	`CCTTAC/AACCAG`	1	--	ng3¹		3	NA	140
	rs17153603^1,2	F,H	79686208(+)	`GAAAAG/AGTTAG`	1	--	ut3¹		7	NA EU EA WA	558
	rs17153599^1,2	F,H	79685501(+)	`GATTTC/TTGAGG`	1	--	ut3¹ ese³		7	NA EU EA WA	550
	rs2465481^1,2	F	79602110(-)	`CGCGCC/TGCAGC`	1	--	ut5¹ ese³		2	MN EA	1252
	rs1138801^1,2	A	79685288(+)	`TTGTAC/AAAACA`	1	--	ut3¹		1	MN	184
	rs12721453^1,2	F	79680028(+)	`TTACAG/AATACA`	1	N/D	mis¹		1	--	22
--	rs28403586^1,2	F	79602122(+)	`CCACCG/AGCGGG`	1	--	ut5¹ ese³		2	MN EA	1252

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HapMap Linkage Disequilibrium images for GNAI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 139310

10/18 Novoseek disease relationships for GNAI1 gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cholera	67.38	17	1662135 (2), 1683639 (1), 7898487 (1), 8752494 (1) (see all 14)
thyroid adenoma	29.42	2	1284336 (1), 16444361 (1)
heart failure	21.88	4	7898487 (1), 1666557 (1), 1978979 (1), 16932076 (1)
pituitary adenoma	5.09	3	9405027 (2), 16444361 (1)
glioma	4.14	1	10410308 (1)
asthma	3.29	1	8752494 (1)
tumors	2.08	8	8784077 (2), 1473250 (1), 16444361 (1), 9362361 (1) (see all 5)
heart failure congestive	0.50	1	1850573 (1)
cancer	0.18	1	17416965 (1)
mood disorders	0.00	1	9016270 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/359 PubMed articles for GNAI1 gene (see all 359 ):

Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PubMed id 3110783)^{2, 3, 4} Bray P....Nirenberg M. (1987)
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (PubMed id 16004878)^{3, 4} Johnston C.A.... Siderovski D.P. (2005)
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{3, 4} Aboulaich N.... Vener A.V. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. (PubMed id 11976690)^{3, 4} Kimple R.J.... Siderovski D.P. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. (PubMed id 9363896)^{1, 7} Daaka Y....Lefkowitz R.J. (1997)
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)^{3, 4} Itoh H.... Kaziro Y. (1988)
Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. (PubMed id 15863506)^{1, 3} Campus F....Torti M. (2005)
Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion. (PubMed id 17416965)^{1, 3} Rimler A....Zisapel N. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2770	HGNC: 4384	AceView: GNAI1	Ensembl:ENSG00000127955	euGenes: HUgn2770
ECgene: GNAI1	H-InvDB: GNAI1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GNAI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GNAI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNAI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNAI1		Antibodies for GNAI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GNAI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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Antibodies for GNAI1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GNAI1 Gene at Home site.
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GNAI1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GNAI1

Summaries
for GNAI1

Genomic Location
for GNAI1

Proteins
for GNAI1

Protein Domains/
Families
for GNAI1

Gene Function
for GNAI1

Pathways & Interactions
for GNAI1

Drugs & Compounds
for GNAI1

Transcripts
for GNAI1

Expression
for GNAI1

Orthologs
for GNAI1

Paralogs
for GNAI1

SNPs/Variants
for GNAI1

Disorders & Mutations
for GNAI1

Medical News
for GNAI1

Publications
for GNAI1

Search for GNAI1

Genome Databases showing GNAI1

Other Databases showing GNAI1

Specialized Databases showing GNAI1

Licensable Technologies
for GNAI1

Services
for GNAI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNAI1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GNAI1

Summariesfor GNAI1

Genomic Locationfor GNAI1

Proteinsfor GNAI1

Protein Domains/Familiesfor GNAI1

Gene Functionfor GNAI1

Pathways & Interactionsfor GNAI1

Drugs & Compoundsfor GNAI1

Transcriptsfor GNAI1

Expression for GNAI1

Orthologsfor GNAI1

Paralogsfor GNAI1

SNPs/Variantsfor GNAI1

Disorders & Mutationsfor GNAI1

Medical Newsfor GNAI1

Publicationsfor GNAI1

Search for GNAI1

Genome Databases showing GNAI1

Other Databases showing GNAI1

Specialized Databases showing GNAI1

Licensable Technologiesfor GNAI1

Servicesfor GNAI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNAI1

Summaries
for GNAI1

Genomic Location
for GNAI1

Proteins
for GNAI1

Protein Domains/
Families
for GNAI1

Gene Function
for GNAI1

Pathways & Interactions
for GNAI1

Drugs & Compounds
for GNAI1

Transcripts
for GNAI1

Expression
for GNAI1

Orthologs
for GNAI1

Paralogs
for GNAI1

SNPs/Variants
for GNAI1

Disorders & Mutations
for GNAI1

Medical News
for GNAI1

Publications
for GNAI1

Licensable Technologies
for GNAI1

Services
for GNAI1