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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAI1 Gene

protein-coding   GIFtS: 66
GCID: GC07P079763

guanine nucleotide binding protein (G protein), alpha inhibiting...
 Explore 64 diseases affiliated with
GNAI1 via
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Biological research products
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Aliases
for GNAI1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity
Polypeptide 11 2
Adenylate Cyclase-Inhibiting G Alpha Protein2 3
Gi2
Gi1 Protein Alpha Subunit2
Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-12

External Ids:    HGNC: 43841   Entrez Gene: 27702   Ensembl: ENSG000001279557   OMIM: 1393105   UniProtKB: P630963   

Export aliases for GNAI1 gene to outside databases

Previous GC identifers: GC07P078299 GC07P079362 GC07P079376 GC07P079408 GC07P079602 GC07P074367


Summaries
for GNAI1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GNAI1:
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and
gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins.
The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of
a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of
RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May
play a role in cell division

summary for GNAI1:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI1


Genomic Views
for GNAI1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAI1 gene promoter:
         TBP   p53   AP-1   ATF-2   CREB   deltaCREB   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNAI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNAI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21-q22

GNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P079763:  view genomic region     (about GC identifiers)

Start:
 79,763,271 bp from pter      End:
 79,848,725 bp from pter
Size:
 85,455 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 79,095,649-79,180,223     

Proteins
for GNAI1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-1  
Size: 354 amino acids; 40361 Da
Subunit: Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14
(via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via
C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha
chain contains the guanine nucleotide binding site
Subcellular location: Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, centrosome.
Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By
similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis.
Detected at the cleavage furrow or the midbody
6/14 PDB 3D structures from and Proteopedia for GNAI1 (see all 14):
1KJY (3D)        1Y3A (3D)        2G83 (3D)        2GTP (3D)        2IK8 (3D)        2OM2 (3D)    
Secondary accessions: A8KA88 B4E2V1 C9J3A4 P04898 P11015 P31871 Q5U074 Q8TAN5 Q9UGA4
Alternative splicing: 2 isoforms:  P63096-1   P63096-2   

Explore the universe of human proteins at neXtProt for GNAI1: NX_P63096

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P63096

    • GNAI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243343.1  NP_002060.4  

    ENSEMBL proteins: 
     ENSP00000391439   ENSP00000343027   ENSP00000389435   ENSP00000410572   ENSP00000388347  
    Reactome Protein details: P63096
    Human Recombinant Protein Products: 
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    Novus Biologicals GNAI1 Proteins
    Novus Biologicals GNAI1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for GNAI1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17635935
    GO:0005794Golgi apparatus ----


    GNAI1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GNAI1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNAI1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I

    Graphical View of Domain Structure for InterPro Entry P63096

    ProtoNet protein and cluster: P63096

    2 Blocks protein families:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    Function
    for GNAI1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of
    RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May
    play a role in cell division

         Genatlas biochemistry entry for GNAI1:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1

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    hsa-miR-323-3p hsa-miR-320a hsa-miR-448 hsa-miR-485-3p hsa-miR-320d hsa-miR-548e hsa-miR-4282 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNAI1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI15537540
    GO:0005525GTP binding ISS--
    GO:0019001guanyl nucleotide binding ----


    GNAI1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for GNAI1:
     Decreased cell number and incr  Increased cell number in G1, s  Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
         Mouse knock-out Gnai1tm1Drs for GNAI1
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gnai1):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 

    GNAI1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GNAI1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/80 super-pathways (see all 80) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    8/9 pathways (see all 9)
    		Development Angiotensin activation of ERK1.00
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development_EDNRB signaling0.54
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    2Development_Dopamine D2 receptor transactivation of EGFR
    		Development_Dopamine D2 receptor transactivation of EGFR1.00
    		Development Alpha-2 adrenergic receptor activation of ERK0.66
    		Development Dopamine D2 receptor transactivation of EGFR1.00
    		Chemotaxis_CXCR4 signaling pathway0.48
    		Development_Alpha-2 adrenergic receptor activation of ERK0.66
    		Chemotaxis CXCR4 signaling pathway0.48
    3Opioid Signalling
    		Opioid Signalling1.00
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    		G-protein mediated events0.55
    		Glutamatergic synapse0.31
    		PLC beta mediated events0.54
    4G Protein Signaling Pathways
    		G Protein Signaling Pathways1.00
    		Signal transduction_PKA signaling0.23
    		Signal transduction cAMP signaling0.44
    		Signal transduction PKA signaling0.23
    		Signal transduction_cAMP signaling0.44
    5G-Beta Gamma Signaling
    		G-Beta Gamma Signaling1.00
    		Relaxin Pathway0.32
    		GHRH Signaling0.46
    		Hedgehog Signaling in Mammals0.22
    		CRHR Pathway0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/23 EMD Millipore Pathways for GNAI1 (see all 23)
        Chemotaxis CXCR4 signaling pathway
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Integrin inside-out signaling
    Development G-Proteins mediated regulation MARK-ERK signaling

    5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI1 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for GNAI1
        Ca, cAMP and Lipid Signaling

    5/25 GeneGo (Thomson Reuters) Pathways for GNAI1 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/14 BioSystems Pathways for GNAI1 (see all 14) 
        Nicotine Activity on Dopaminergic Neurons
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Signal Transduction of S1P Receptor
    TSH signaling pathway

    5/24        Reactome Pathways for GNAI1 (see all 24)
        Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion
    Neuronal System
    Opioid Signalling

    4 PharmGKB Pathways for GNAI1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/14         Kegg Pathways  (Kegg details for GNAI1) (see all 14):
        Chemokine signaling pathway
    Axon guidance
    Tight junction
    Gap junction
    Leukocyte transendothelial migration


    GNAI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/197 Interacting proteins for GNAI1 (P630961, 2, 3 ENSP000003430274) via UniProtKB, MINT, STRING, and/or I2D (see all 197)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812741, 3, ENSP000002641264EBI-618639,EBI-618655 I2D: score=4 STRING: ENSP00000264126
    GPR50Q135852, 3, ENSP000002183164MINT-2836319 I2D: score=1 STRING: ENSP00000218316
    MT1AP047312, 3, ENSP000002907054MINT-2836337 I2D: score=1 STRING: ENSP00000290705
    NUMA1Q149801, 3EBI-618639,EBI-521611 I2D: score=3 
    GNG2P597682, 3, ENSP000003344484MINT-8189440 I2D: score=1 STRING: ENSP00000334448
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS--
    GO:0006906vesicle fusion ----
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ISS--


    GNAI1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNAI1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNAI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for GNAI1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Mastoparan XG protein activator peptide[72093-22-2]
    MastoparanActivates Gi and Go[72093-21-1]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
    MelittinInhibits Gs and stimulates Gi activity[20449-79-0]
    NF 023 Selective, competitive P2X antagonist [104869-31-0]

    4 HMDB Compounds for GNAI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    GuanineGUN (see all 26)73-40-5--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for GNAI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Tetrafluoroaluminate Ion-- --target--17139284 17016423 10592235

    10/77 Novoseek chemical compound relationships for GNAI1 gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pertussis 81 12 7898487 (1), 16899767 (1), 1953712 (1), 1309343 (1) (see all 12)
    adenylate 75.9 67 2109182 (4), 8384153 (2), 8282007 (2), 2159482 (2) (see all 48)
    gtp 74.9 27 1795017 (2), 2109182 (1), 8282007 (1), 7514261 (1) (see all 21)
    forskolin 71.7 6 2109182 (1), 8282007 (1), 10930355 (1), 10410308 (1) (see all 6)
    mastoparan 70.7 7 1938104 (1), 8307108 (1), 7802684 (1), 9371843 (1) (see all 7)
    guanosine 5'-o-(3-thiotriphosphate) 69.7 1 2170379 (1)
    guanine 67.7 17 2109182 (1), 2129393 (1), 1648103 (1), 9293962 (1) (see all 17)
    cyclic amp 66.9 12 7542872 (2), 8282007 (1), 10737627 (1), 7526047 (1) (see all 10)
    isoproterenol 64.9 14 12972572 (2), 10930355 (1), 7473226 (1), 1330500 (1) (see all 10)
    cholera toxin 59.6 2 1330500 (1), 9556056 (1)

    Search CenterWatch for drugs/clinical trials and news about GNAI1 

    Transcripts
    for GNAI1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNAI1 gene (2 alternative transcripts): 
    NM_001256414.1  NM_002069.5  

    Unigene Cluster for GNAI1:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
    Hs.134587  [show with all ESTs]
    Unigene Representative Sequence: BC026326
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442586 ENST00000490206 ENST00000351004(uc003uhb.1 uc011kgt.1)
    ENST00000418742 ENST00000457358 ENST00000447650

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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate GNAI1 (see all 15):
    hsa-miR-323-3p hsa-miR-320a hsa-miR-448 hsa-miR-485-3p hsa-miR-320d hsa-miR-548e hsa-miR-4282 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GNAI1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF055013.1 AF493905.1 AK292953.1 AK304442.1 AL049933.1 BC026326.1 BT019775.1 M17219.1 

    8 DOTS entries:

    DT.116051  DT.121094745  DT.92424890  DT.92424892  DT.121094753  DT.121094757  DT.100816334  DT.92008477 

    24/194 AceView cDNA sequences (see all 194):

    R37785 CR594203 R37344 CB045322 AV708892 BX397644 CR600756 F02356 
    AF055013 CR616478 CD677445 AA406364 BU622732 BU675856 Z98491 CR595689 
    BF509333 CF141281 R20361 AI367770 BX502815 BF512396 BQ021391 BU689706 

    GeneLoc Exon Structure


    Expression
    for GNAI1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAATTATGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See GNAI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAI1

    SOURCE GeneReport for Unigene cluster: Hs.134587
        SABiosciences Expression via Pathway-Focused PCR Arrays including GNAI1: 
              Tight Junctions in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for GNAI1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNAI1 gene from 8/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNAI11 guanine nucleotide binding protein (G protein), alpha more 87.1(n)
    98.02(a)    		   396368  NM_205403.1  NP_990734.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GNAI16
    		 --
    		 98(a)
    		 1 ↔ 1
    		 5(93360700-93386642)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.219372 X. laevis mRNA for alpha-subunit of G-protein, type more 81.5(n)    X56089.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC053164.12   -- 79.46(n)   393946  BC053164.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta G-ialpha65A1 , 3 G-protein coupled receptor protein signaling
    pathway more3
    G protein alphai subunit 65A1    		 77(a)
    (best of 3)3
    67.23(n)1
    77.97(a)1    		   387651  NM_058154.41  NP_477502.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea goa-13
    gpa-161    		 guanine nucleotide-binding protein3
    Protein GPA-161    		 69(a)
    (best of 14)3
    62.9(n)1
    66.95(a)1    		   I(7530272-7533917)3
    1716751  NM_058389.21  NP_490790.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons XLG16
    XLG26
    (see all 4)    		 extra-large GTP-binding protein 2
    (see all 4)    		 9(a)
    8(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 2(9995478-9999122)
    4(16441179-16445005)
    rice
    (Oryza sativa)    		 Liliopsida Os.53022 Oryza sativa (japonica cultivar-group) mRNA for G protein more 71.1(n)    AB026176.1 


    ENSEMBL Gene Tree for GNAI1 (if available)
    TreeFam Gene Tree for GNAI1 (if available) 

    Paralogs
    for GNAI1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAI1 gene
    GNAQ2  GNA142  GNA112  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA152  GNAI22  GNA122  GNAZ2  GNAO12  
    18 SIMAP similar genes for GNAI1 using alignment to 5 protein entries:     GNAI1_HUMAN (see all proteins):
    GNAI3    GNAI2    DKFZp686O0962    GNAT2    GNAT3    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNA15    GNAL    GNAS    GSA    WUGSC

    GNAI1 for paralogs           About GeneDecksing



    Genomic Variants
    for GNAI1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1449 NCBI SNPs in GNAI1 are shown (see all 1449)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1901565531,2
    		--79762254(+) TTTAGA/GGCAGC 1 -- us2k10--------
    rs1455353091,2
    		--79762305(+) CTGTTA/GTCATT 1 -- us2k10--------
    rs671582761,2
    		C--79762482(+) GATGG-/AAGTA 
                ATGTT     		1 -- us2k10--------
    rs1387083341,2
    		C,--79762482(+) GATGG-/AAGTA 
                ATGTT     		1 -- us2k10--------
    rs1160435041,2
    		--79763264(+) TCTCCC/GCCGAT 2 -- us2k10--------
    rs58851661,2
    		C,--79763269(+) CCGATC/-TGTTA 2 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs725634691,2
    		C,--79763269(+) CCGAT-/CTTGTT 2 -- us2k10--------
    rs27144651,2
    		C,F,H,--79763302(+) GCACCA/GTAGAT 2 -- us2k119Minor allele frequency- G:0.27NS EA NA WA 2340
    rs1417347901,2
    		--79763310(+) GATCCA/CCTCCT 2 -- us2k10--------
    rs1814864461,2
    		--79763386(+) CACGGC/TCATAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNAI1 (79763271 - 79848725 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GNAI1: --

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    Disorders / Diseases
    for GNAI1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNAI1 for disorders           About GeneDecksing

    OMIM gene information: 139310    OMIM disorders: --

    20/64 diseases for GNAI1 (see all 64):    About MalaCards
    neurocirculatory asthenia    congenital stationary night blindness    night blindness    cluster headache
    congestive heart failure    ocular albinism    transvestism    pituitary adenoma
    insulin resistance    essential hypertension    anorexia nervosa    polycystic kidney disease
    headache    hypertrophic cardiomyopathy    atopic dermatitis    thyroid adenoma
    albinism    chronic lymphocytic leukemia    adenoma    epithelial ovarian cancer

    10/18 Novoseek disease relationships for GNAI1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 67.4 17 1662135 (2), 1683639 (1), 7898487 (1), 8752494 (1) (see all 14)
    thyroid adenoma 28.6 2 1284336 (1), 16444361 (1)
    heart failure 23.9 4 7898487 (1), 1666557 (1), 1978979 (1), 16932076 (1)
    pituitary adenoma 4.2 3 9405027 (2), 16444361 (1)
    asthma 3.39 1 8752494 (1)
    glioma 2.72 1 10410308 (1)
    tumors 2.2 8 8784077 (2), 1473250 (1), 16444361 (1), 9362361 (1) (see all 5)
    cancer 0.196 1 17416965 (1)
    insulin resistance 0 2 9277377 (2)
    essential hypertension 0 1 8888689 (1)

    Human Genome Epidemiology (HuGE) Navigator: GNAI1 (4 documents)

    Export disorders for GNAI1 gene to outside databases

    Publications
    for GNAI1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAI1 gene, integrated from 9 sources (see all 450):
    (articles sorted by number of sources associating them with GNAI1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PubMed id 3110783)1, 2, 3 Bray P....Nirenberg M. (1987)
    2. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (2007)
    3. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (PubMed id 16004878)1, 2 Johnston C.A.... Siderovski D.P. (2005)
    4. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. (PubMed id 11976690)1, 2 Kimple R.J.... Siderovski D.P. (2002)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)1, 2 Itoh H.... Kaziro Y. (1988)
    10. Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. (PubMed id 15863506)1, 9 Campus F....Torti M. (2005)

    External Searches for GNAI1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GNAI1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2770 HGNC: 4384 AceView: GNAI1 Ensembl:ENSG00000127955 euGenes: HUgn2770
    ECgene: GNAI1 Kegg: 2770 H-InvDB: GNAI1

    Other Databases showing GNAI1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNAI1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAI1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNAI1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNAI1 gene:
    Search GeneIP for patents involving GNAI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for GNAI1 gene

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    About This Section

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