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Aliases for GNAI1 Gene

Aliases for GNAI1 Gene

  • G Protein Subunit Alpha I1 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 1 2 3 5
  • Adenylate Cyclase-Inhibiting G Alpha Protein 3 4
  • Gi1 Protein Alpha Subunit 2 3
  • Gi 3

External Ids for GNAI1 Gene

Previous GeneCards Identifiers for GNAI1 Gene

  • GC07P078299
  • GC07P079362
  • GC07P079376
  • GC07P079408
  • GC07P079602
  • GC07P079763
  • GC07P074367

Summaries for GNAI1 Gene

Entrez Gene Summary for GNAI1 Gene

  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GNAI1 Gene

GNAI1 (G Protein Subunit Alpha I1) is a Protein Coding gene. Diseases associated with GNAI1 include Pertussis and Cholera. Among its related pathways are Axon guidance and Platelet activation. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAI1 Gene

  • Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935).

Tocris Summary for GNAI1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNAI1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAI1 Gene

Genomics for GNAI1 Gene

Regulatory Elements for GNAI1 Gene

Enhancers for GNAI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNAI1 on UCSC Golden Path with GeneCards custom track

Promoters for GNAI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNAI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNAI1 Gene

Chromosome:
7
Start:
80,133,955 bp from pter
End:
80,219,409 bp from pter
Size:
85,455 bases
Orientation:
Plus strand

Genomic View for GNAI1 Gene

Genes around GNAI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNAI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAI1 Gene

Proteins for GNAI1 Gene

  • Protein details for GNAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63096-GNAI1_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(i) subunit alpha-1
    Protein Accession:
    P63096
    Secondary Accessions:
    • A8KA88
    • B4E2V1
    • C9J3A4
    • P04898
    • P11015
    • P31871
    • Q5U074
    • Q8TAN5
    • Q9UGA4

    Protein attributes for GNAI1 Gene

    Size:
    354 amino acids
    Molecular mass:
    40361 Da
    Quaternary structure:
    • Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1 (PubMed:22383884). Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2 (PubMed:18434541). GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (PubMed:22383884). Interacts (GDP-bound form) with GPSM1; this inhibits guanine nucleotide exchange and GTP binding (By similarity). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains); this inhibits guanine nucleotide exchange (PubMed:22952234). Interacts with RGS10; this strongly enhances GTP hydrolysis (PubMed:8774883, PubMed:18434541). Interacts with RGS1 and RGS16; this strongly enhances GTPase activity (PubMed:18434541). Interacts with RGS4 (PubMed:18434541). Interacts with RGS12 (PubMed:18434541). Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains) (PubMed:11976690, PubMed:18434541, PubMed:21115486, PubMed:22383884). Interacts with RGS3, RGS6, RGS7, RGS8, RGS17, RGS18 and RGS20 (in vitro) (PubMed:18434541). Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity).

    Three dimensional structures from OCA and Proteopedia for GNAI1 Gene

    Alternative splice isoforms for GNAI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNAI1 Gene

Proteomics data for GNAI1 Gene at MOPED

Post-translational modifications for GNAI1 Gene

  • (Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
  • Ubiquitination at Lys 92
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAI1 Gene

No data available for DME Specific Peptides for GNAI1 Gene

Domains & Families for GNAI1 Gene

Graphical View of Domain Structure for InterPro Entry

P63096

UniProtKB/Swiss-Prot:

GNAI1_HUMAN :
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAI1: view

No data available for Gene Families for GNAI1 Gene

Function for GNAI1 Gene

Molecular function for GNAI1 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935).

Gene Ontology (GO) - Molecular Function for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0001664 G-protein coupled receptor binding ISS --
GO:0003924 GTPase activity TAS --
GO:0005515 protein binding IPI 15537540
GO:0031683 G-protein beta/gamma-subunit complex binding IEA,IBA --
genes like me logo Genes that share ontologies with GNAI1: view
genes like me logo Genes that share phenotypes with GNAI1: view

Animal Models for GNAI1 Gene

MGI Knock Outs for GNAI1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNAI1 Gene

Localization for GNAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAI1 Gene

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody (PubMed:17635935). Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). {ECO:0000250, ECO:0000250 UniProtKB:P10824, ECO:0000269 PubMed:17635935}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAI1 Gene COMPARTMENTS Subcellular localization image for GNAI1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 3
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 17635935
GO:0005834 heterotrimeric G-protein complex TAS 3110783
GO:0030496 midbody IDA 17635935
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with GNAI1: view

Pathways & Interactions for GNAI1 Gene

genes like me logo Genes that share pathways with GNAI1: view

SIGNOR curated interactions for GNAI1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for GNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0043434 response to peptide hormone ISS --
genes like me logo Genes that share ontologies with GNAI1: view

Drugs & Compounds for GNAI1 Gene

(50) Drugs for GNAI1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanine Experimental Pharma 0
Tetrafluoroaluminate Ion Experimental Pharma Target 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(35) Additional Compounds for GNAI1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
mastoparan
72093-21-1
[D-Trp7,9,10]-Substance P
89430-38-6
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNAI1 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNAI1: view

Transcripts for GNAI1 Gene

Unigene Clusters for GNAI1 Gene

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAI1 Gene

No ASD Table

Relevant External Links for GNAI1 Gene

GeneLoc Exon Structure for
GNAI1
ECgene alternative splicing isoforms for
GNAI1

Expression for GNAI1 Gene

mRNA expression in normal human tissues for GNAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNAI1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for GNAI1 Gene

This gene is overexpressed in Brain (8.2), Nasal epithelium (8.2), Fetal Brain (7.6), Nasopharynx (7.1), and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAI1 Gene



SOURCE GeneReport for Unigene cluster for GNAI1 Gene Hs.134587

genes like me logo Genes that share expression patterns with GNAI1: view

Protein tissue co-expression partners for GNAI1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GNAI1 Gene

Orthologs for GNAI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNAI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNAI1 35
  • 93.79 (n)
  • 100 (a)
GNAI1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai1 35
  • 88.51 (n)
  • 100 (a)
Gnai1 16
Gnai1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNAI1 35
  • 99.72 (n)
  • 100 (a)
GNAI1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnai1 35
  • 88.61 (n)
  • 99.72 (a)
dog
(Canis familiaris)
Mammalia GNAI1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAI1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNAI1 35
  • 87.1 (n)
  • 98.02 (a)
GNAI1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAI1 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnai1 35
  • 83.05 (n)
  • 98.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21937 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
gnai1 35
  • 78.91 (n)
  • 96.89 (a)
gnai1 36
  • 97 (a)
OneToMany
gnaia 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 37
  • 77 (a)
G-oalpha47A 37
  • 68 (a)
Galpha73B 37
  • 35 (a)
G-ialpha65A 35
  • 67.23 (n)
  • 77.97 (a)
G-ialpha65A 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005904 35
  • 66.95 (n)
  • 80.45 (a)
worm
(Caenorhabditis elegans)
Secernentea goa-1 37
  • 69 (a)
gpa-1 37
  • 45 (a)
gpa-10 37
  • 35 (a)
gpa-11 37
  • 40 (a)
gpa-14 37
  • 31 (a)
gpa-15 37
  • 43 (a)
gpa-2 37
  • 44 (a)
gpa-3 37
  • 50 (a)
gpa-4 37
  • 60 (a)
gpa-6 37
  • 38 (a)
gpa-7 37
  • 54 (a)
gpa-8 37
  • 39 (a)
gpa-9 37
  • 36 (a)
odr-3 37
  • 48 (a)
gpa-16 35
  • 62.9 (n)
  • 66.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 38
soybean
(Glycine max)
eudicotyledons Gma.159 35
barley
(Hordeum vulgare)
Liliopsida Hv.253 35
rice
(Oryza sativa)
Liliopsida Os.5302 35
wheat
(Triticum aestivum)
Liliopsida Ta.14280 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2644 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 36
  • 83 (a)
OneToMany
Species with no ortholog for GNAI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GNAI1 Gene

ENSEMBL:
Gene Tree for GNAI1 (if available)
TreeFam:
Gene Tree for GNAI1 (if available)

Paralogs for GNAI1 Gene

Paralogs for GNAI1 Gene

genes like me logo Genes that share paralogs with GNAI1: view

Variants for GNAI1 Gene

Sequence variations from dbSNP and Humsavar for GNAI1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs916905 -- 80,171,031(+) AGGTT(C/T)ATTAC intron-variant
rs998251 -- 80,142,235(-) GATAC(C/T)GATGA intron-variant
rs1013942 -- 80,140,735(+) AAAAA(A/T)TTTTT intron-variant
rs1034702 -- 80,141,120(+) gccct(A/C/G)tgagg intron-variant
rs1138801 -- 80,218,036(+) TTGTA(A/C)AAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNAI1 Gene

Variant ID Type Subtype PubMed ID
nsv888512 CNV Loss 21882294
nsv507398 CNV Insertion 20534489

Variation tolerance for GNAI1 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNAI1 Gene

Disorders for GNAI1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GNAI1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pertussis
  • bordetella infection
cholera
  • cholera - vibrio cholerae
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search GNAI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNAI1

Genetic Association Database (GAD)
GNAI1
Human Genome Epidemiology (HuGE) Navigator
GNAI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNAI1
genes like me logo Genes that share disorders with GNAI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNAI1 Gene

Publications for GNAI1 Gene

  1. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PMID: 3110783) Bray P. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 67
  2. Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. (PMID: 15863506) Campus F. … Torti M. (J. Biol. Chem. 2005) 3 23
  3. IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi. (PMID: 14602724) Ferreira I.A. … Akkerman J.W. (J. Biol. Chem. 2004) 3 23
  4. CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. (PMID: 14625285) Chandrasekar B. … Mummidi S. (J. Biol. Chem. 2004) 3 23
  5. CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. (PMID: 11168387) Mukhopadhyay S. … Howlett A.C. (Eur. J. Biochem. 2001) 3 23

Products for GNAI1 Gene

Sources for GNAI1 Gene

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