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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNAI1 Gene

protein-coding   GIFtS: 68
GCID: GC07P079763

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting
Activity Polypeptide 11 2
Gi1 Protein Alpha Subunit1 2
Adenylate Cyclase-Inhibiting G Alpha Protein2 3
Gi2
Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-12

External Ids:    HGNC: 43841   Entrez Gene: 27702   Ensembl: ENSG000001279557   OMIM: 1393105   UniProtKB: P630963   

Export aliases for GNAI1 gene to outside databases

Previous GC identifers: GC07P078299 GC07P079362 GC07P079376 GC07P079408 GC07P079602 GC07P074367


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNAI1 Gene:
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and
gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other
proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded
protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for GNAI1 Gene: 
GNAI1 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1) is a protein-coding gene. Diseases associated with GNAI1 include neurocirculatory asthenia, and transvestism, and among its related super-pathways are G-protein mediated events and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association
of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma
membrane. May play a role in cell division

summary for GNAI1 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.

Gene Wiki entry for GNAI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNAI1 gene promoter:
         TBP   p53   AP-1   ATF-2   CREB   deltaCREB   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNAI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNAI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNAI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21-q22

GNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNAI1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P079763:  view genomic region     (about GC identifiers)

Start:
79,763,271 bp from pter      End:
79,848,725 bp from pter
Size:
85,455 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 79,095,649-79,180,223     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(i) subunit alpha-1  
Size: 354 amino acids; 40361 Da
Subunit: Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with
RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with
RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and
gamma. The alpha chain contains the guanine nucleotide binding site
Subcellular location: Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A
and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells,
but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody
6/14 PDB 3D structures from and Proteopedia for GNAI1 (see all 14):
1KJY (3D)        1Y3A (3D)        2G83 (3D)        2GTP (3D)        2IK8 (3D)        2OM2 (3D)    
Secondary accessions: A8KA88 B4E2V1 C9J3A4 P04898 P11015 P31871 Q5U074 Q8TAN5 Q9UGA4
Alternative splicing: 2 isoforms:  P63096-1   P63096-2   

Explore the universe of human proteins at neXtProt for GNAI1: NX_P63096

Explore proteomics data for GNAI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63096

  • GNAI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNAI1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243343.1  NP_002060.4  

    ENSEMBL proteins: 
     ENSP00000391439   ENSP00000343027   ENSP00000389435   ENSP00000410572   ENSP00000388347  
    Reactome Protein details: P63096
    Human Recombinant Protein Products for GNAI1: 
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    Novus Biologicals GNAI1 Proteins
    Novus Biologicals GNAI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GNAI1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17635935
    GO:0005765lysosomal membrane IDA17897319
    GO:0005794Golgi apparatus ----

    GNAI1 for ontologies           About GeneDecksing



    GNAI1 Antibody Products: 
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    Assay Products for GNAI1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR001408 Gprotein_alpha_I
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P63096

    ProtoNet protein and cluster: P63096

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB001408 G-protein alpha subunit group I signature


    UniProtKB/Swiss-Prot: GNAI1_HUMAN, P63096
    Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily


    GNAI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNAI1_HUMAN, P63096
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they
    inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association
    of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma
    membrane. May play a role in cell division

         Genatlas biochemistry entry for GNAI1:
    guanine nucleotide binding protein (G protein),alpha inhibiting activity,polypeptide 1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI15537540
    GO:0005525GTP binding ISS--
    GO:0019001guanyl nucleotide binding ----
         
    GNAI1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GNAI1:
     Decreased cell number and incr  Increased cell number in G1, s  Increased gamma-H2AX phosphory  Increased homologous recombina 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnai1):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 
     skeleton 

    GNAI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gnai1tm1Drs for GNAI1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNAI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNAI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNAI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNAI1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGNAI1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNAI1 About   (see all 83)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/23 EMD Millipore Pathways for GNAI1 (see all 23)
        Chemotaxis CXCR4 signaling pathway
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Integrin inside-out signaling
    Development G-Proteins mediated regulation MARK-ERK signaling

    5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNAI1 (see all 57)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for GNAI1
        Ca, cAMP and Lipid Signaling

    5/25 GeneGo (Thomson Reuters) Pathways for GNAI1 (see all 25)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-i signaling cascades
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/14 BioSystems Pathways for GNAI1 (see all 14)
        G Protein Signaling Pathways
    Nicotine Activity on Dopaminergic Neurons
    Signal Transduction of S1P Receptor
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway

    5/24        Reactome Pathways for GNAI1 (see all 24)
        Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion
    Neuronal System
    Opioid Signalling

    4 PharmGKB Pathways for GNAI1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/23         Kegg Pathways  (Kegg details for GNAI1) (see all 23):
        Chemokine signaling pathway
    Axon guidance
    Tight junction
    Gap junction
    Leukocyte transendothelial migration


    GNAI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/202 Interacting proteins for GNAI1 (P630961, 2, 3 ENSP000003430274) via UniProtKB, MINT, STRING, and/or I2D (see all 202)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812741, 3, ENSP000002641264EBI-618639,EBI-618655 I2D: score=4 STRING: ENSP00000264126
    GPR50Q135852, 3, ENSP000002183164MINT-2836319 I2D: score=1 STRING: ENSP00000218316
    MT1AP047312, 3, ENSP000002907054MINT-2836337 I2D: score=1 STRING: ENSP00000290705
    NUMA1Q149801, 3EBI-618639,EBI-521611 I2D: score=3 
    GPSM3Q9Y4H43, ENSP000003641804I2D: score=2 STRING: ENSP00000364180
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006906vesicle fusion ----
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ISS--
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----

    GNAI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNAI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNAI1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    4 HMDB Compounds for GNAI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    GuanineGUN (see all 26)73-40-5--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for GNAI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Tetrafluoroaluminate Ion-- --target--17139284 17016423 10592235

    10/77 Novoseek inferred chemical compound relationships for GNAI1 gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pertussis 81 12 7898487 (1), 16899767 (1), 1953712 (1), 1309343 (1) (see all 12)
    adenylate 75.9 67 2109182 (4), 8384153 (2), 8282007 (2), 2159482 (2) (see all 48)
    gtp 74.9 27 1795017 (2), 2109182 (1), 8282007 (1), 7514261 (1) (see all 21)
    forskolin 71.7 6 2109182 (1), 8282007 (1), 10930355 (1), 10410308 (1) (see all 6)
    mastoparan 70.7 7 1938104 (1), 8307108 (1), 7802684 (1), 9371843 (1) (see all 7)
    guanosine 5'-o-(3-thiotriphosphate) 69.7 1 2170379 (1)
    guanine 67.7 17 2109182 (1), 2129393 (1), 1648103 (1), 9293962 (1) (see all 17)
    cyclic amp 66.9 12 7542872 (2), 8282007 (1), 10737627 (1), 7526047 (1) (see all 10)
    isoproterenol 64.9 14 12972572 (2), 10930355 (1), 7473226 (1), 1330500 (1) (see all 10)
    cholera toxin 59.6 2 1330500 (1), 9556056 (1)

    Search CenterWatch for drugs/clinical trials and news about GNAI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for GNAI1 gene (2 alternative transcripts): 
    NM_001256414.1  NM_002069.5  

    Unigene Cluster for GNAI1:

    Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
    Hs.134587  [show with all ESTs]
    Unigene Representative Sequence: BC026326
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442586 ENST00000490206 ENST00000351004(uc003uhb.1 uc011kgt.1)
    ENST00000418742 ENST00000457358 ENST00000447650

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    Additional mRNA sequence: 

    AF055013.1 AF493905.1 AK292953.1 AK304442.1 AL049933.1 BC026326.1 BT019775.1 M17219.1 

    8 DOTS entries:

    DT.116051  DT.121094745  DT.92424890  DT.92424892  DT.121094753  DT.121094757  DT.100816334  DT.92008477 

    24/194 AceView cDNA sequences (see all 194):

    BU689706 BU622732 BX502815 AL539524 R20361 BX397644 AI367770 BF509333 
    F02356 CA435583 CR621915 BF512396 AL536202 CR600756 AV708892 CR616478 
    BQ021391 AF055013 CR595689 U47728 AA406364 BU675856 CB131951 BM988854 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNAI1 expression in normal human tissues (normalized intensities)      GNAI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATTATGG
    GNAI1 Expression
    About this image


    GNAI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See GNAI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNAI1

    SOURCE GeneReport for Unigene cluster: Hs.134587
        SABiosciences Expression via Pathway-Focused PCR Arrays including GNAI1: 
              Tight Junctions in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNAI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNAI1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnai11 , 5 guanine nucleotide binding protein (G protein), alpha more1, 5 88.51(n)1
    100(a)1
      5 (8.16 cM)5
    146771  NM_010305.11  NP_034435.11 
     182651355 
    chicken
    (Gallus gallus)
    Aves GNAI11 guanine nucleotide binding protein (G protein), alpha more 87.1(n)
    98.02(a)
      396368  NM_205403.1  NP_990734.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNAI16
    Uncharacterized protein
    98(a)
    1 ↔ 1
    5(93360700-93387609)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.219372 X. laevis mRNA for alpha-subunit of G-protein, type more 81.5(n)    X56089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053164.12   -- 79.46(n)   393946  BC053164.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta G-ialpha65A1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    G protein alphai subunit 65A1
    77(a)
    (best of 3)3
    67.23(n)1
    77.97(a)1
      387651  NM_058154.41  NP_477502.11 
    worm
    (Caenorhabditis elegans)
    Secernentea goa-13
    gpa-161
    guanine nucleotide-binding protein3
    Protein GPA-161
    69(a)
    (best of 14)3
    62.9(n)1
    66.95(a)1
      I(7530272-7533917)3
    1716751  NM_058389.21  NP_490790.11 
    soybean
    (Glycine max)
    eudicotyledons Gma.1592 G.max mRNA for alpha subunit of G protein 70.16(n)    X95582.1 
    rice
    (Oryza sativa)
    Liliopsida Os.53022 Oryza sativa (japonica cultivar-group) mRNA for G protein more 71.1(n)    AB026176.1 


    ENSEMBL Gene Tree for GNAI1 (if available)
    TreeFam Gene Tree for GNAI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNAI1 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNAI22  GNA152  GNAZ2  GNAO12  
    18 SIMAP similar genes for GNAI1 using alignment to 5 protein entries:     GNAI1_HUMAN (see all proteins):
    GNAI3    GNAI2    DKFZp686O0962    GNAT2    GNAT3    GNAT1
    GNAZ    GNAO1    GNA11    GNA14    GNAQ    GNA12
    GNA13    GNA15    GNAL    GNAS    GSA    WUGSC

    GNAI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1748 SNPs in GNAI1 are shown (see all 1748)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901565531,2
    --79762254(+) TTTAGA/GGCAGC 1 -- us2k10--------
    rs1455353091,2
    --79762305(+) CTGTTA/GTCATT 1 -- us2k10--------
    rs671582761,2
    C--79762482(+) GATGG-/AAGTA 
            
    ATGTT
    1 -- us2k10--------
    rs1160435041,2
    --79763264(+) TCTCCC/GCCGAT 2 -- us2k10--------
    rs679980141,2
    C--79763270(+) CGATT-/CGTTAC 2 -- us2k10--------
    rs27144651,2
    C,F,H--79763302(+) GCACCA/GTAGAT 2 -- us2k119Minor allele frequency- G:0.27NS EA NA WA 2340
    rs1417347901,2
    --79763310(+) GATCCA/CCTCCT 2 -- us2k10--------
    rs1814864461,2
    --79763386(+) CACGGC/TCATAA 2 -- us2k10--------
    rs1505505471,2
    --79763428(+) TGTGCA/TGCTCT 2 -- us2k10--------
    rs1863845561,2
    --79763460(+) GGAGAC/TTGGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNAI1 (79763271 - 79848725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNAI1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507398CNV Insertion20534489
    nsv888512CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139310    OMIM disorders: --

    20/60 diseases for GNAI1 (see all 60):    About MalaCards
    neurocirculatory asthenia    transvestism    pertussis    cluster headache
    headache    thyroid adenoma    congenital stationary night blindness    cholera
    night blindness    fibromyalgia    ocular albinism    congestive heart failure
    fainting    albinism    blindness    trypanosomiasis
    scoliosis    essential hypertension    adenoma    chagas disease


    GNAI1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/18 Novoseek inferred disease relationships for GNAI1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 67.4 17 1662135 (2), 1683639 (1), 7898487 (1), 8752494 (1) (see all 14)
    thyroid adenoma 28.6 2 1284336 (1), 16444361 (1)
    heart failure 23.9 4 7898487 (1), 1666557 (1), 1978979 (1), 16932076 (1)
    pituitary adenoma 4.2 3 9405027 (2), 16444361 (1)
    asthma 3.39 1 8752494 (1)
    glioma 2.72 1 10410308 (1)
    tumors 2.2 8 8784077 (2), 1473250 (1), 16444361 (1), 9362361 (1) (see all 5)
    cancer 0.196 1 17416965 (1)
    insulin resistance 0 2 9277377 (2)
    essential hypertension 0 1 8888689 (1)

    Genetic Association Database (GAD): GNAI1
    Human Genome Epidemiology (HuGE) Navigator: GNAI1 (4 documents)

    Export disorders for GNAI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNAI1 gene, integrated from 9 sources (see all 465):
    (articles sorted by number of sources associating them with GNAI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (PubMed id 3110783)1, 2, 3 Bray P....Nirenberg M. (1987)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2 Cho H. and Kehrl J.H. (2007)
    5. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (PubMed id 16004878)1, 2 Johnston C.A.... Siderovski D.P. (2005)
    6. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    9. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. (PubMed id 11976690)1, 2 Kimple R.J.... Siderovski D.P. (2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2770 HGNC: 4384 AceView: GNAI1 Ensembl:ENSG00000127955 euGenes: HUgn2770
    ECgene: GNAI1 Kegg: 2770 H-InvDB: GNAI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNAI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNAI1 gene:
    Search GeneIP for patents involving GNAI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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