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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNA15 Gene

protein-coding   GIFtS: 61
GCID: GC19P003140

Guanine Nucleotide Binding Protein (G Protein), Alpha 15...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 15 (Gq Class)1 2     Guanine Nucleotide-Binding Protein Subunit Alpha-162 3
GNA162 3 5     G-Protein Subunit Alpha-152 3
Epididymis Tissue Protein Li 17E2 3     G-Protein Subunit Alpha-162 3
G Alpha-152 3     Guanine Nucleotide-Binding Protein Subunit Alpha-152
G Alpha-162 3     

External Ids:    HGNC: 43831   Entrez Gene: 27692   Ensembl: ENSG000000605587   OMIM: 1393145   UniProtKB: P306793   

Export aliases for GNA15 gene to outside databases

Previous GC identifers: GC19P003228 GC19P003076 GC19P003087 GC19P002905


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GNA15 Gene: 
GNA15 (guanine nucleotide binding protein (G protein), alpha 15 (Gq class)) is a protein-coding gene. Diseases associated with GNA15 include mccune albright syndrome, and pseudohypoparathyroidism, and among its related super-pathways are GHRH Signaling and fMLP Pathway. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNA15_HUMAN, P30679
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNA15 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates
PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNA15 gene promoter:
         COUP-TF1   HOXA3   HNF-4alpha2   HNF-4alpha1   Evi-1   YY1   MZF-1   COUP-TF   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNA15 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNA15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GNA15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA15 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003140:  view genomic region     (about GC identifiers)

Start:
3,136,191 bp from pter      End:
3,163,767 bp from pter
Size:
27,577 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNA15_HUMAN, P30679 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-15  
Size: 374 amino acids; 43568 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site
Secondary accessions: E9KL40 E9KL47 O75247 Q53XK2

Explore the universe of human proteins at neXtProt for GNA15: NX_P30679

Explore proteomics data for GNA15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30679

  • GNA15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNA15 Protein Expression
    REFSEQ proteins: NP_002059.2  
    ENSEMBL proteins: 
     ENSP00000262958   ENSP00000467256  
    Reactome Protein details: P30679
    Human Recombinant Protein Products for GNA15: 
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    Novus Biologicals GNA15 Protein
    Novus Biologicals GNA15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex NAS10571060
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic to internal side of plasma membrane IBA--

    GNA15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR000654 Gprotein_alpha_Q
     IPR011025 GproteinA_insert
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P30679

    ProtoNet protein and cluster: P30679

    2 Blocks protein domains:
    IPB000654 G-protein alpha subunit group Q signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA15_HUMAN, P30679
    Similarity: Belongs to the G-alpha family. G(q) subfamily


    GNA15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNA15_HUMAN, P30679
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

         Genatlas biochemistry entry for GNA15:
    guanine nucleotide binding protein (G protein),alpha 15 (Gq class),mediating pertussis toxin-resistant stimulation
    of phospholipase C beta

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IEA--
    GO:0004871signal transducer activity IGI10571060
    GO:0005525GTP binding NAS--
    GO:0019001guanyl nucleotide binding ----
         
    GNA15 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gna15):
     normal 

    GNA15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gna15tm1Tmw for GNA15

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNA15 
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    hsa-miR-4283
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNA15 About   (see all 49)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    Relaxin Pathway0.37
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.32
    CRHR Pathway0.44
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.30
    fMLP Pathway0.43
    3Thromboxane signalling through TP receptor
    ADP signalling through P2Y purinoceptor 10.78
    Thromboxane signalling through TP receptor0.78
    Signal amplification0.78
    Thrombin signalling through proteinase activated receptors (PARs)0.67
    4GPCR Pathway
    GPCR Pathway0.62
    NFAT in Immune Response0.58
    Breast Cancer Regulation by Stathmin10.58
    Estrogen Pathway0.55
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for GNA15
        Development Activation of ERK by Alpha-1 adrenergic receptors
    G-protein signaling G-Protein beta/gamma signaling cascades
    Development A1 receptor signaling
    Immune response ICOS pathway in T-helper cell

    5/60 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA15 (see all 60)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    ERK5 Signaling

    5 GeneGo (Thomson Reuters) Pathways for GNA15
        Immune response ICOS pathway in T-helper cell
    G-protein signaling G-Protein beta/gamma signaling cascades
    Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Development A1 receptor signaling
    Development Activation of ERK by Alpha-1 adrenergic receptors

    5/7 BioSystems Pathways for GNA15 (see all 7)
        G Protein Signaling Pathways
    Endothelin
    Arf6 signaling events
    S1P2 pathway
    S1P3 pathway

    5/17        Reactome Pathways for GNA15 (see all 17)
        Hemostasis
    GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Metabolism
    Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)

    1 PharmGKB Pathway for GNA15
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for GNA15):
        Calcium signaling pathway
    Chagas disease (American trypanosomiasis)
    Amoebiasis


    GNA15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNA15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/189 Interacting proteins for GNA15 (P306793 ENSP000002629584) via UniProtKB, MINT, STRING, and/or I2D (see all 189)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
    GRM2Q144163, ENSP000003784924I2D: score=2 STRING: ENSP00000378492
    LTB4RQ157223, ENSP000003074454I2D: score=2 STRING: ENSP00000307445
    CHRM2P081723, ENSP000003199844I2D: score=1 STRING: ENSP00000319984
    HRH4Q9H3N83, ENSP000002569064I2D: score=1 STRING: ENSP00000256906
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ----
    GO:0007202activation of phospholipase C activity TAS7797501

    GNA15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNA15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNA15    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNA15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section

    REFSEQ mRNAs for GNA15 gene: 
    NM_002068.2  

    Unigene Cluster for GNA15:

    Guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
    Hs.73797  [show with all ESTs]
    Unigene Representative Sequence: NM_002068
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262958(uc010xhf.1 uc002lxf.2) ENST00000592455 ENST00000586082

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    Additional mRNA sequence: 

    AF493904.1 AK291329.1 AK300481.1 BC013585.1 BT009850.1 GU727637.1 GU727645.1 M63904.1 

    5 DOTS entries:

    DT.453812  DT.97805795  DT.100739808  DT.100008032  DT.87014157 

    24/71 AceView cDNA sequences (see all 71):

    T99302 BX282684 BM480054 BQ221428 BX279571 CR594417 BG258764 AF493904 
    AW002009 BC013585 BQ223866 CD367471 BX453720 AL532310 AI333010 BX340690 
    BU192417 BT009850 AL568761 AI817049 AL541152 H61280 NM_002068 M63904 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GNA15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:              -                                             
    SP2:                                                            


    ECgene alternative splicing isoforms for GNA15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNA15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCATCTTA
    GNA15 Expression
    About this image


    See GNA15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNA15

    SOURCE GeneReport for Unigene cluster: Hs.73797

    UniProtKB/Swiss-Prot: GNA15_HUMAN, P30679
    Tissue specificity: Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNA15 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gna151 , 5 guanine nucleotide binding protein, alpha 151, 5 82.35(n)1
    84.49(a)1
      10 (39.72 cM)5
    146761  NM_010304.31  NP_034434.11 
     815023065 
    lizard
    (Anolis carolinensis)
    Reptilia GNA156
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343717.1(250955-272801)
    zebrafish
    (Danio rerio)
    Actinopterygii gna15.11 guanine nucleotide binding protein (G protein), alpha more 61.72(n)
    58.54(a)
      445232  NM_001003626.1  NP_001003626.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-113 guanine nucleotide-binding protein 37(a)   II(4252625-4254323)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA16
    GTP-binding alpha subunit of the heterotrimeric G ...
    28(a)
    1 → many
    VIII(113499-114917)


    ENSEMBL Gene Tree for GNA15 (if available)
    TreeFam Gene Tree for GNA15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNA15 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNA122  GNAI22  GNAZ2  GNAO12  GNAI12  
    16 SIMAP similar genes for GNA15 using alignment to 2 protein entries:     GNA15_HUMAN (see all proteins):
    GNAQ    GNA11    GNA14    GNA13    GNAT1    GNAT2
    GNAT3    GNA12    GNAI1    GNAI3    GNAI2    GNAZ
    GNAO1    GNAL    GNAS    GSA

    GNA15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/985 SNPs in GNA15 are shown (see all 985)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826016661,2
    C--3059847(+) GTGTGA/TGTATA 1 -- us2k10--------
    rs1166949681,2
    F--3059857(+) ATATAT/GACACA 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1491607761,2
    --3059861(+) ATACAC/TACATA 1 -- us2k10--------
    rs735278621,2
    C--3134217(+) TATGTA/GTATTA 1 -- us2k10--------
    rs2016236191,2
    --3134240(+) TATGT-/GAGTGTA 1 -- us2k10--------
    rs106742161,2
    C--3134244(+) TATAT-/AT/TA 
            
    GTATG
    1 -- us2k12NA CSA 4
    rs118798801,2
    C,A,H--3134259(+) tgtgtA/Gtatat 1 -- us2k10--------
    rs118824851,2
    C,A,H--3134275(+) tgtgtC/Gtatat 1 -- us2k10--------
    rs118798811,2
    C,A,H--3134277(+) tgtctA/Ctatat 1 -- us2k10--------
    rs346279651,2
    C--3134287(+) TTGTGTA/-TATAT 1 -- us2k11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for GNA15 (3136191 - 3163767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for GNA15 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717923CNV Deletion23290073
    esv2584592CNV Insertion19546169
    nsv509716CNV Insertion20534489
    esv1660661CNV Insertion17803354
    dgv3648n71CNV Loss21882294
    nsv910694CNV Loss21882294
    dgv3644n71CNV Loss21882294
    nsv910714CNV Loss21882294
    dgv47n68CNV Loss17160897
    nsv910697CNV Loss21882294

    2 SABiosciences Cancer Mutation PCR Assays for GNA15:
    Cosmic IdAA Change
    108657p.E173K
    107599p.R366C
    SeqTarget long-range PCR primers for resequencing GNA15
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139314    OMIM disorders: --

    13 diseases for GNA15:    About MalaCards
    mccune albright syndrome    pseudohypoparathyroidism    fibrous dysplasia    fainting
    trypanosomiasis    chagas disease    pertussis    epididymitis
    cholera    thrombosis    huntington's disease    retinitis
    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for GNA15:
    Cholera     Pseudohypoparathyroidism     Pertussis     Neuroblastoma
    Fibrous dysplasia

    GNA15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNA15

    Export disorders for GNA15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNA15 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with GNA15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    2. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134)1, 4 Smith N.L....Vasan R.S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Evolution of the mammalian G protein alpha subunit multigene family. (PubMed id 1302014)1, 3 Wilkie T.M....Simon M.I. (1992)
    6. G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. (PubMed id 1905813)1, 2 Amatruda T.T. III... Simon M.I. (1991)
    7. Ectopic expression of the heterotrimeric G15 protein i n pancreatic carcinoma and its potential in cancer signal transduction. (PubMed id 23200847)1 Giovinazzo F....Innamorati G. (2013)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Differential PKC-dependent and -independent PKD activa tion by G protein a subunits of the Gq family: selective stimulation of PKD Ser^ 7^4^8 autophosphorylation by Gaq. (PubMed id 22227248)1 Waldron R.T....Rozengurt E. (2012)
    10. GI+16 interacts with tetratricopeptide repeat 1 (TPR1) through its I^3 region to activate Ras independently of phospholipase CI^ signal ing. (PubMed id 21486497)1 Liu A.M....Wong Y.H. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2769 HGNC: 4383 AceView: GNA15 Ensembl:ENSG00000060558 euGenes: HUgn2769
    ECgene: GNA15 Kegg: 2769 H-InvDB: GNA15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNA15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNA15 gene:
    Search GeneIP for patents involving GNA15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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