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Aliases for GNA15 Gene

Aliases for GNA15 Gene

  • G Protein Subunit Alpha 15 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 15 (Gq Class) 2 3 5
  • Guanine Nucleotide-Binding Protein Subunit Alpha-16 3 4
  • Epididymis Tissue Protein Li 17E 3 4
  • G-Protein Subunit Alpha-15 3 4
  • G-Protein Subunit Alpha-16 3 4
  • G Alpha-15 3 4
  • G Alpha-16 3 4
  • GNA16 3 4

External Ids for GNA15 Gene

Previous GeneCards Identifiers for GNA15 Gene

  • GC19P003228
  • GC19P003076
  • GC19P003087
  • GC19P003140
  • GC19P002905

Summaries for GNA15 Gene

GeneCards Summary for GNA15 Gene

GNA15 (G Protein Subunit Alpha 15) is a Protein Coding gene. Diseases associated with GNA15 include Pertussis and Primary Bacterial Infectious Disease. Among its related pathways are Thromboxane signalling through TP receptor and EphB-EphrinB Signaling. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNA15 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNA15 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA15 Gene

Genomics for GNA15 Gene

Regulatory Elements for GNA15 Gene

Enhancers for GNA15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNA15 on UCSC Golden Path with GeneCards custom track

Promoters for GNA15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNA15 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNA15 Gene

Chromosome:
19
Start:
3,136,032 bp from pter
End:
3,163,769 bp from pter
Size:
27,738 bases
Orientation:
Plus strand

Genomic View for GNA15 Gene

Genes around GNA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA15 Gene

Proteins for GNA15 Gene

  • Protein details for GNA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30679-GNA15_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-15
    Protein Accession:
    P30679
    Secondary Accessions:
    • E9KL40
    • E9KL47
    • O75247
    • Q53XK2

    Protein attributes for GNA15 Gene

    Size:
    374 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNA15 Gene

Proteomics data for GNA15 Gene at MOPED

Post-translational modifications for GNA15 Gene

  • Ubiquitination at Lys 201 and Lys 213
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA15 Gene

Domains & Families for GNA15 Gene

Suggested Antigen Peptide Sequences for GNA15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30679

UniProtKB/Swiss-Prot:

GNA15_HUMAN :
  • Belongs to the G-alpha family. G(q) subfamily.
Family:
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA15: view

No data available for Gene Families for GNA15 Gene

Function for GNA15 Gene

Molecular function for GNA15 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha 15 (Gq class),mediating pertussis toxin-resistant stimulation of phospholipase C beta
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Gene Ontology (GO) - Molecular Function for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0031683 G-protein beta/gamma-subunit complex binding IEA --
genes like me logo Genes that share ontologies with GNA15: view
genes like me logo Genes that share phenotypes with GNA15: view

Animal Models for GNA15 Gene

MGI Knock Outs for GNA15:

Animal Model Products

miRNA for GNA15 Gene

miRTarBase miRNAs that target GNA15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA15 Gene

Localization for GNA15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNA15 Gene COMPARTMENTS Subcellular localization image for GNA15 gene
Compartment Confidence
cytosol 5
plasma membrane 5
mitochondrion 3
cytoskeleton 2
extracellular 2
nucleus 2
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GNA15 Gene

Pathways & Interactions for GNA15 Gene

genes like me logo Genes that share pathways with GNA15: view

Gene Ontology (GO) - Biological Process for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with GNA15: view

No data available for SIGNOR curated interactions for GNA15 Gene

Drugs & Compounds for GNA15 Gene

(3) Drugs for GNA15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNA15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNA15 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNA15: view

Transcripts for GNA15 Gene

mRNA/cDNA for GNA15 Gene

Unigene Clusters for GNA15 Gene

Guanine nucleotide binding protein (G protein), alpha 15 (Gq class):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNA15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for GNA15 Gene

GeneLoc Exon Structure for
GNA15
ECgene alternative splicing isoforms for
GNA15

Expression for GNA15 Gene

mRNA expression in normal human tissues for GNA15 Gene

mRNA differential expression in normal tissues according to GTEx for GNA15 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.8), Whole Blood (x8.0), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for GNA15 Gene

This gene is overexpressed in Cervix (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNA15 Gene



SOURCE GeneReport for Unigene cluster for GNA15 Gene Hs.73797

mRNA Expression by UniProt/SwissProt for GNA15 Gene

P30679-GNA15_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with GNA15: view

Protein tissue co-expression partners for GNA15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GNA15 Gene

Orthologs for GNA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNA15 35
  • 87.17 (n)
  • 92.51 (a)
GNA15 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gna15 35
  • 82.35 (n)
  • 84.49 (a)
Gna15 16
Gna15 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gna15 35
  • 83.16 (n)
  • 85.83 (a)
dog
(Canis familiaris)
Mammalia GNA15 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNA15 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNA15 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNA15 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496529 35
  • 62.24 (n)
  • 58.54 (a)
zebrafish
(Danio rerio)
Actinopterygii gna15.1 35
  • 61.81 (n)
  • 58.54 (a)
gna15.1 36
  • 57 (a)
OneToMany
gna15.2 36
  • 54 (a)
OneToMany
gna15.3 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Galpha73B 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gpa-11 37
  • 37 (a)
gpa-1 36
  • 42 (a)
ManyToMany
gpa-15 36
  • 36 (a)
ManyToMany
gpa-16 36
  • 45 (a)
ManyToMany
gpa-2 36
  • 37 (a)
ManyToMany
gpa-3 36
  • 38 (a)
ManyToMany
gpa-4 36
  • 39 (a)
ManyToMany
gpa-7 36
  • 42 (a)
ManyToMany
odr-3 36
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for GNA15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA15 Gene

ENSEMBL:
Gene Tree for GNA15 (if available)
TreeFam:
Gene Tree for GNA15 (if available)

Paralogs for GNA15 Gene

Paralogs for GNA15 Gene

(16) SIMAP similar genes for GNA15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNA15: view

Variants for GNA15 Gene

Sequence variations from dbSNP and Humsavar for GNA15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_028000 -
rs7257374 -- 3,162,011(+) CTGGG(C/T)GACAG intron-variant
rs7257773 -- 3,163,605(+) TTTGC(A/G)GACGA utr-variant-3-prime
rs12975990 -- 3,160,831(+) ctctg(C/G/T)ctcca intron-variant
rs12975997 -- 3,160,832(+) tctgc(C/T)tccat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNA15 Gene

Variant ID Type Subtype PubMed ID
nsv910694 CNV Loss 21882294
dgv47n68 CNV Loss 17160897
dgv3644n71 CNV Loss 21882294
nsv910697 CNV Loss 21882294
nsv509716 CNV Insertion 20534489
dgv3645n71 CNV Loss 21882294
dgv3647n71 CNV Loss 21882294
nsv910714 CNV Loss 21882294
esv2584592 CNV Insertion 19546169
esv1660661 CNV Insertion 17803354
esv2717923 CNV Deletion 23290073
dgv3648n71 CNV Loss 21882294

Variation tolerance for GNA15 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNA15 Gene

Disorders for GNA15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GNA15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pertussis
  • bordetella infection
primary bacterial infectious disease
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
- elite association - COSMIC cancer census association via MalaCards
Search GNA15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNA15

Genetic Association Database (GAD)
GNA15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNA15
genes like me logo Genes that share disorders with GNA15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA15 Gene

Publications for GNA15 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 67
  2. Evolution of the mammalian G protein alpha subunit multigene family. (PMID: 1302014) Wilkie T.M. … Simon M.I. (Nat. Genet. 1992) 2 3
  3. GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses. (PMID: 25701539) Zanini S. … Kidd M. (Cell. Signal. 2015) 3
  4. Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction. (PMID: 23200847) Giovinazzo F. … Innamorati G. (Cell. Signal. 2013) 3
  5. Heterotrimeric G-protein, GI+16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer. (PMID: 24204697) Avasarala S. … Winn R.A. (PLoS ONE 2013) 3

Products for GNA15 Gene

Sources for GNA15 Gene

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