Aliases for GNA15 Gene
External Ids for GNA15 Gene
Previous GeneCards Identifiers for GNA15 Gene
GeneCards Summary for GNA15 Gene
GNA15 (G Protein Subunit Alpha 15) is a Protein Coding gene. Diseases associated with GNA15 include Pertussis and Dyschromatosis Universalis Hereditaria. Among its related pathways are CCR5 Pathway in Macrophages and Phospholipase-C Pathway. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNA15 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.