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Aliases for GNA15 Gene

Aliases for GNA15 Gene

  • G Protein Subunit Alpha 15 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 15 (Gq Class) 2 3
  • Guanine Nucleotide-Binding Protein Subunit Alpha-16 3 4
  • Epididymis Tissue Protein Li 17E 3 4
  • G-Protein Subunit Alpha-16 3 4
  • G Alpha-15 3 4
  • G Alpha-16 3 4
  • GNA16 3 4
  • Guanine Nucleotide-Binding Protein Subunit Alpha-15 3
  • G-Protein Subunit Alpha-15 4

External Ids for GNA15 Gene

Previous GeneCards Identifiers for GNA15 Gene

  • GC19P003228
  • GC19P003076
  • GC19P003087
  • GC19P003140
  • GC19P002905

Summaries for GNA15 Gene

GeneCards Summary for GNA15 Gene

GNA15 (G Protein Subunit Alpha 15) is a Protein Coding gene. Diseases associated with GNA15 include Pertussis and Charcot-Marie-Tooth Disease, Dominant Intermediate F. Among its related pathways are Calcium signaling pathway and ADP signalling through P2Y purinoceptor 1. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNA15 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Tocris Summary for GNA15 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Additional gene information for GNA15 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA15 Gene

Genomics for GNA15 Gene

Regulatory Elements for GNA15 Gene

Enhancers for GNA15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H003131 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.1 -1.6 -1608 8 PKNOX1 ATF1 TCF12 ZNF766 ZNF143 ATF7 RUNX3 ZC3H11A JUNB ZNF592 GNA15 NMRK2 FZR1 LOC390876
GH19H003150 2 FANTOM5 Ensembl ENCODE dbSUPER 20.2 +17.4 17357 6 HDGF PKNOX1 FOXA2 ARNT YBX1 ZNF766 FOS DEK SP3 JUNB ZNF77 CACTIN GNA11 ZNF555 CACTIN-AS1 DOT1L SPPL2B SF3A2 AP3D1 GNA15
GH19H003164 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +29.5 29492 1 CTCF HLF ZFP64 CEBPB ZNF781 ZNF518A ZNF697 POLR2A PRDM12 ZBTB33 GNA15 GNA11 AES APBA3 S1PR4 FZR1 GC19M003162 GC19M003161
GH19H003163 0.8 ENCODE dbSUPER 39.4 +26.6 26566 0 RAD51 NFYB CHD4 NFYC USF2 GNA15 GNA11 AES GC19M003161 GC19M003162
GH19H003175 1.5 FANTOM5 ENCODE dbSUPER 20.6 +40.7 40703 2 HDGF FOXA2 NFIB SREBF2 GLIS2 SCRT2 RCOR1 ATF7 FOS CREM SF3A2 GNA15 APBA3 S1PR4 CACTIN-AS1 ENSG00000267139 GNA11 CACTIN ENSG00000268670 ZNF77
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNA15 on UCSC Golden Path with GeneCards custom track

Promoters for GNA15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105998 468 1001 BCOR SMARCA5 KLF1 NR2F1 KLF17 ZMYM3 DPF2 ZNF217 CBX1 EED

Genomic Location for GNA15 Gene

Chromosome:
19
Start:
3,136,032 bp from pter
End:
3,163,769 bp from pter
Size:
27,738 bases
Orientation:
Plus strand

Genomic View for GNA15 Gene

Genes around GNA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA15 Gene

Proteins for GNA15 Gene

  • Protein details for GNA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30679-GNA15_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-15
    Protein Accession:
    P30679
    Secondary Accessions:
    • E9KL40
    • E9KL47
    • O75247
    • Q53XK2

    Protein attributes for GNA15 Gene

    Size:
    374 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

neXtProt entry for GNA15 Gene

Post-translational modifications for GNA15 Gene

  • Ubiquitination at isoforms=201 and isoforms=213
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GNA15

No data available for DME Specific Peptides for GNA15 Gene

Domains & Families for GNA15 Gene

Gene Families for GNA15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GNA15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30679

UniProtKB/Swiss-Prot:

GNA15_HUMAN :
  • Belongs to the G-alpha family. G(q) subfamily.
Family:
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA15: view

Function for GNA15 Gene

Molecular function for GNA15 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha 15 (Gq class),mediating pertussis toxin-resistant stimulation of phospholipase C beta
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Phenotypes From GWAS Catalog for GNA15 Gene

Gene Ontology (GO) - Molecular Function for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity IGI 10571060
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding IEA --
genes like me logo Genes that share ontologies with GNA15: view
genes like me logo Genes that share phenotypes with GNA15: view

Animal Models for GNA15 Gene

MGI Knock Outs for GNA15:

Animal Model Products

CRISPR Products

miRNA for GNA15 Gene

miRTarBase miRNAs that target GNA15

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GNA15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA15 Gene

Localization for GNA15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA15 gene
Compartment Confidence
plasma membrane 5
cytosol 4
mitochondrion 3
extracellular 2
cytoskeleton 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex NAS 10571060
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNA15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GNA15 Gene

Pathways & Interactions for GNA15 Gene

genes like me logo Genes that share pathways with GNA15: view

Gene Ontology (GO) - Biological Process for GNA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007202 activation of phospholipase C activity TAS 7797501
genes like me logo Genes that share ontologies with GNA15: view

No data available for SIGNOR curated interactions for GNA15 Gene

Drugs & Compounds for GNA15 Gene

(3) Drugs for GNA15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNA15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNA15 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNA15: view

Transcripts for GNA15 Gene

mRNA/cDNA for GNA15 Gene

Unigene Clusters for GNA15 Gene

Guanine nucleotide binding protein (G protein), alpha 15 (Gq class):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GNA15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GNA15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for GNA15 Gene

GeneLoc Exon Structure for
GNA15
ECgene alternative splicing isoforms for
GNA15

Expression for GNA15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNA15 Gene

mRNA differential expression in normal tissues according to GTEx for GNA15 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.8), Whole Blood (x8.0), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for GNA15 Gene

This gene is overexpressed in Cervix (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNA15 Gene



Protein tissue co-expression partners for GNA15 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNA15 Gene:

GNA15

SOURCE GeneReport for Unigene cluster for GNA15 Gene:

Hs.73797

mRNA Expression by UniProt/SwissProt for GNA15 Gene:

P30679-GNA15_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for GNA15 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(2.6)
  • Heart(2.5)
  • Muscle(2.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with GNA15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA15 Gene

Orthologs for GNA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNA15 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNA15 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNA15 33 34
  • 87.17 (n)
oppossum
(Monodelphis domestica)
Mammalia GNA15 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gna15 33
  • 83.16 (n)
mouse
(Mus musculus)
Mammalia Gna15 16 34 33
  • 82.35 (n)
lizard
(Anolis carolinensis)
Reptilia GNA15 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496529 33
  • 62.24 (n)
zebrafish
(Danio rerio)
Actinopterygii gna15.1 33 34
  • 61.81 (n)
gna15.2 34
  • 54 (a)
OneToMany
gna15.3 34
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Galpha73B 35
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gpa-16 34
  • 45 (a)
ManyToMany
gpa-1 34
  • 42 (a)
ManyToMany
gpa-7 34
  • 42 (a)
ManyToMany
gpa-4 34
  • 39 (a)
ManyToMany
gpa-3 34
  • 38 (a)
ManyToMany
odr-3 34
  • 38 (a)
ManyToMany
gpa-11 35
  • 37 (a)
gpa-2 34
  • 37 (a)
ManyToMany
gpa-15 34
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for GNA15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA15 Gene

ENSEMBL:
Gene Tree for GNA15 (if available)
TreeFam:
Gene Tree for GNA15 (if available)

Paralogs for GNA15 Gene

Paralogs for GNA15 Gene

(16) SIMAP similar genes for GNA15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNA15: view

Variants for GNA15 Gene

Sequence variations from dbSNP and Humsavar for GNA15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000111596 -- 3,162,541(+) GCCCG(A/G)AGTCC intron-variant
rs1000121611 -- 3,162,760(+) GGGAG(A/G)GTCCT intron-variant
rs1000204914 -- 3,135,125(+) GGCAC(A/T)CAGTT upstream-variant-2KB
rs1000239405 -- 3,137,242(+) TCATA(A/G)GCAGA intron-variant
rs1000239753 -- 3,140,418(+) TCCTC(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNA15 Gene

Variant ID Type Subtype PubMed ID
dgv47n68 CNV loss 17160897
esv1660661 CNV insertion 17803354
esv2584592 CNV insertion 19546169
esv2717923 CNV deletion 23290073
nsv1072842 CNV deletion 25765185
nsv509716 CNV insertion 20534489
nsv953947 CNV deletion 24416366

Variation tolerance for GNA15 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNA15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA15 Gene

Disorders for GNA15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GNA15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pertussis
  • bordetella infection
charcot-marie-tooth disease, dominant intermediate f
  • charcot-marie-tooth disease dominant intermediate f
dyschromatosis universalis hereditaria
  • duh
- elite association - COSMIC cancer census association via MalaCards
Search GNA15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNA15

Genetic Association Database (GAD)
GNA15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNA15
genes like me logo Genes that share disorders with GNA15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNA15 Gene

Publications for GNA15 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 60
  2. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith NL … Vasan RS (Circulation. Cardiovascular genetics 2010) 3 45 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Evolution of the mammalian G protein alpha subunit multigene family. (PMID: 1302014) Wilkie TM … Simon MI (Nature genetics 1992) 2 3 60

Products for GNA15 Gene

Sources for GNA15 Gene

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