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Aliases for GNA14 Gene

Aliases for GNA14 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha 14 2 3
  • G-Protein Subunit Alpha-14 4
  • G Alpha-14 4

External Ids for GNA14 Gene

Previous GeneCards Identifiers for GNA14 Gene

  • GC09M071085
  • GC09M071894
  • GC09M073607
  • GC09M075495
  • GC09M077268
  • GC09M079227
  • GC09M080037
  • GC09M049869

Summaries for GNA14 Gene

Entrez Gene Summary for GNA14 Gene

  • This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

GeneCards Summary for GNA14 Gene

GNA14 (Guanine Nucleotide Binding Protein (G Protein), Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include pertussis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNA14 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Tocris Summary for GNA14 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA14 Gene

Genomics for GNA14 Gene

Regulatory Elements for GNA14 Gene

Genomic Location for GNA14 Gene

77,423,079 bp from pter
77,648,316 bp from pter
225,238 bases
Minus strand

Genomic View for GNA14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA14 Gene

Proteins for GNA14 Gene

  • Protein details for GNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-14
    Protein Accession:
    Secondary Accessions:
    • B1ALW3

    Protein attributes for GNA14 Gene

    355 amino acids
    Molecular mass:
    41571 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site

neXtProt entry for GNA14 Gene

Proteomics data for GNA14 Gene at MOPED

Post-translational modifications for GNA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNA14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA14 Gene

Domains for GNA14 Gene

Graphical View of Domain Structure for InterPro Entry



  • O95837
  • Belongs to the G-alpha family. G(q) subfamily.
genes like me logo Genes that share domains with GNA14: view

No data available for Gene Families for GNA14 Gene

Function for GNA14 Gene

Molecular function for GNA14 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis toxin-resistant stimulation of phospholipase C beta
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Gene Ontology (GO) - Molecular Function for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GNA14: view
genes like me logo Genes that share phenotypes with GNA14: view

miRNA for GNA14 Gene

miRTarBase miRNAs that target GNA14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNA14 Gene

Localization for GNA14 Gene

Subcellular locations from

Jensen Localization Image for GNA14 Gene COMPARTMENTS Subcellular localization image for GNA14 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GNA14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GNA14 Gene

Pathways for GNA14 Gene

genes like me logo Genes that share pathways with GNA14: view

Gene Ontology (GO) - Biological Process for GNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 10191087
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with GNA14: view

Compounds for GNA14 Gene

(5) Tocris Compounds for GNA14 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNA14 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with GNA14: view

Transcripts for GNA14 Gene

mRNA/cDNA for GNA14 Gene

Unigene Clusters for GNA14 Gene

Guanine nucleotide binding protein (G protein), alpha 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNA14 Gene

No ASD Table

Relevant External Links for GNA14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNA14 Gene

mRNA expression in normal human tissues for GNA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNA14 Gene

SOURCE GeneReport for Unigene cluster for GNA14 Gene Hs.657795

genes like me logo Genes that share expressions with GNA14: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNA14 Gene

Orthologs for GNA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNA14 35
  • 99.25 (n)
  • 99.72 (a)
GNA14 36
  • 100 (a)
(Bos Taurus)
Mammalia GNA14 35
  • 92.02 (n)
  • 97.75 (a)
GNA14 36
  • 98 (a)
(Canis familiaris)
Mammalia GNA14 35
  • 91.08 (n)
  • 97.46 (a)
GNA14 36
  • 97 (a)
(Mus musculus)
Mammalia Gna14 35
  • 89.3 (n)
  • 96.9 (a)
Gna14 16
Gna14 36
  • 97 (a)
(Monodelphis domestica)
Mammalia GNA14 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia GNA14 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Gna14 35
  • 88.92 (n)
  • 97.46 (a)
(Gallus gallus)
Aves GNA14 35
  • 80.41 (n)
  • 91.24 (a)
GNA14 36
  • 91 (a)
(Anolis carolinensis)
Reptilia GNA14 36
  • 75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Gna14 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gna14 35
  • 77.97 (n)
  • 90.4 (a)
(Danio rerio)
Actinopterygii gna11a 36
  • 75 (a)
gna14a 35
  • 69.68 (n)
  • 75.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17760 36
  • 60 (a)
CG30054 36
  • 63 (a)
Galpha49B 36
  • 66 (a)
Galpha49B 37
  • 72 (a)
CG17760 37
  • 51 (a)
(Caenorhabditis elegans)
Secernentea egl-30 36
  • 74 (a)
gpa-6 37
  • 39 (a)
gpa-10 37
  • 36 (a)
gpa-15 37
  • 39 (a)
gpa-8 37
  • 38 (a)
gpa-1 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11283 36
  • 69 (a)
Species with no ortholog for GNA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA14 Gene

Gene Tree for GNA14 (if available)
Gene Tree for GNA14 (if available)

Paralogs for GNA14 Gene

Paralogs for GNA14 Gene

Selected SIMAP similar genes for GNA14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNA14: view

Variants for GNA14 Gene

Sequence variations from dbSNP and Humsavar for GNA14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs526580 -- 77,530,582(+) aaata(A/C)tctct intron-variant
rs527811 -- 77,428,279(-) agtac(A/G)ctgaa intron-variant
rs527838 -- 77,428,272(-) gaaac(C/G)ctgtc intron-variant
rs716080 -- 77,581,695(+) AAGTT(G/T)TATCT intron-variant
rs731943 -- 77,430,178(+) AAGCC(A/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNA14 Gene

Variant ID Type Subtype PubMed ID
esv7342 OTHER Inversion 19470904
esv26092 CNV Loss 19812545
esv2562696 CNV Insertion 19546169
esv2463816 CNV Insertion 19546169
esv271163 CNV Insertion 20981092
nsv831629 CNV Gain 17160897
nsv893485 CNV Loss 21882294
nsv893486 CNV Loss 21882294
esv2738610 CNV Deletion 23290073
esv2669994 CNV Deletion 23128226
esv21709 CNV Loss 19812545
esv2671344 CNV Deletion 23128226
nsv893487 CNV Gain 21882294

Relevant External Links for GNA14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA14 Gene

Disorders for GNA14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GNA14 Gene including...

Search for GNA14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GNA14 Gene

Relevant External Links for GNA14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GNA14: view

No data available for UniProtKB/Swiss-Prot for GNA14 Gene

Publications for GNA14 Gene

  1. Genomic organization of the human G-alpha-14 and G-alpha-Q genes and mutation analysis in chorea-acanthocytosis (CHAC). (PMID: 10191087) Rubio J.P. … Monaco A.P. (Genomics 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PMID: 17620339) Pedone K.H. … Hepler J.R. (J. Biol. Chem. 2007) 2 3

Products for GNA14 Gene

Sources for GNA14 Gene

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