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GNA14 Gene

protein-coding   GIFtS: 62
GCID: GC09M080037

Guanine Nucleotide Binding Protein (G Protein), Alpha 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 141 2
G Alpha-142 3
G-Protein Subunit Alpha-142 3
Guanine Nucleotide-Binding Protein 142
Guanine Nucleotide-Binding Protein Subunit Alpha-142

External Ids:    HGNC: 43821   Entrez Gene: 96302   Ensembl: ENSG000001560497   OMIM: 6043975   UniProtKB: O958373   

Export aliases for GNA14 gene to outside databases

Previous GC identifers: GC09M071085 GC09M071894 GC09M073607 GC09M075495 GC09M077268 GC09M079227 GC09M049869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNA14 Gene:
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers
consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins,
more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin
resistant activation of phospholipase C-beta and its downstream effectors.(provided by RefSeq, Feb 2009)

GeneCards Summary for GNA14 Gene:
GNA14 (guanine nucleotide binding protein (G protein), alpha 14) is a protein-coding gene. Diseases associated with GNA14 include pertussis, and chorea-acanthocytosis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNA14 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates
PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNA14 gene promoter:
         Nkx3-1   Nkx3-1 v4   ISGF-3   AML1a   FOXD3   Nkx3-1 v1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNA14 promoter sequence
   Search Chromatin IP Primers for GNA14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNA14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21   Ensembl cytogenetic band:  9q21.2   HGNC cytogenetic band: 9q21

GNA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA14 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M080037:  view genomic region     (about GC identifiers)

Start:
80,037,995 bp from pter      End:
80,263,232 bp from pter
Size:
225,238 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-14  
Size: 355 amino acids; 41571 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site

Explore the universe of human proteins at neXtProt for GNA14: NX_O95837

Explore proteomics data for GNA14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNA14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004288.1  
    ENSEMBL proteins: 
     ENSP00000365807  
    Reactome Protein details: O95837

    GNA14 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR000654 Gprotein_alpha_Q
     IPR011025 GproteinA_insert
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O95837

    ProtoNet protein and cluster: O95837

    2 Blocks protein domains:
    IPB000654 G-protein alpha subunit group Q signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837
    Similarity: Belongs to the G-alpha family. G(q) subfamily


    GNA14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNA14_HUMAN, O95837
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

         Genatlas biochemistry entry for GNA14:
    guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis
    toxin-resistant stimulation of phospholipase C beta

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity IEA--
    GO:0004871signal transducer activity IBA--
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    GNA14 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GNA14:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased viability  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNA14
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNA14

    miRNA
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    miRTarBase miRNAs that target GNA14:
    hsa-mir-335-5p (MIRT018573)

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    2 qRT-PCR Assays for microRNAs that regulate GNA14:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidGNA14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNA14

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IBA--

    GNA14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNA14 About   (see all 43)  
    See pathways by source

    SuperPathContained pathways About
    1G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    Relaxin Pathway0.37
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.32
    CRHR Pathway0.44
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.30
    fMLP Pathway0.43
    3ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Thromboxane signalling through TP receptor0.79
    ADP signalling through P2Y purinoceptor 10.79
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    4GPCR Pathway
    GPCR Pathway0.62
    NFAT in Immune Response0.58
    Breast Cancer Regulation by Stathmin10.58
    Estrogen Pathway0.55
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNA14 (see all 60)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    ERK5 Signaling

    1 GeneGo (Thomson Reuters) Pathway for GNA14
        Development Activation of ERK by Alpha-1 adrenergic receptors

    Selected BioSystems Pathways for GNA14 (see all 6)
        G Protein Signaling Pathways
    LPA receptor mediated events
    Sphingosine 1-phosphate (S1P) pathway
    S1P3 pathway
    S1P2 pathway

    Selected Reactome Pathways for GNA14 (see all 6)
        Acetylcholine regulates insulin secretion
    Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
    ADP signalling through P2Y purinoceptor 1
    G alpha (q) signalling events
    Thromboxane signalling through TP receptor


    3 Kegg Pathways  (Kegg details for GNA14):
        Calcium signaling pathway
    Chagas disease (American trypanosomiasis)
    Amoebiasis


    GNA14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNA14
    Interactions:

        GeneGlobe Interaction Network for GNA14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNA14 (O958372, 3 ENSP000003658074) via UniProtKB, MINT, STRING, and/or I2D (see all 782)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRM2P081723, ENSP000003199844I2D: score=1 STRING: ENSP00000319984
    OPRL1P411463, ENSP000003367644I2D: score=1 STRING: ENSP00000336764
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    CXCR1P250243, ENSP000002956834I2D: score=1 STRING: ENSP00000295683
    CXCR2P250253, ENSP000003196354I2D: score=1 STRING: ENSP00000319635
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10191087
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--

    GNA14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNA14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNA14    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GNA14 gene: 
    NM_004297.3  

    Unigene Cluster for GNA14:

    Guanine nucleotide binding protein (G protein), alpha 14
    Hs.657795  [show with all ESTs]
    Unigene Representative Sequence: NM_004297
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341700(uc004aku.3) ENST00000464095
    miRNA
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    hsa-miR-124 hsa-miR-506
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GNA14

    Additional mRNA sequence: 

    AF105201.1 AF493903.1 AK312460.1 BC027886.1 

    6 DOTS entries:

    DT.70105382  DT.100700606  DT.95074990  DT.121212078  DT.97825328  DT.91935462 

    Selected AceView cDNA sequences (see all 30):

    NM_004297 CR595826 AF493903 AF105201 BC027886 AI263118 BP370141 BX333156 
    BI489883 BI761212 BG545383 AI800090 BV174904 AI629022 CD299466 AI685379 
    BI838805 AA603929 CD299264 BX333157 N75416 BI832845 BQ026199 AI264963 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNA14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACCAAAGA
    GNA14 Expression
    About this image


    GNA14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Lung (Respiratory System)
             Trachea
    GNA14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNA14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657795
        Custom PCR Arrays for GNA14
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNA14 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gna141 , 5 guanine nucleotide binding protein, alpha 141, 5 89.3(n)1
    96.9(a)1
      19 (11.29 cM)5
    146751  NM_008137.41  NP_032163.31 
     164356675 
    chicken
    (Gallus gallus)
    Aves GNA141 guanine nucleotide binding protein (G protein), alpha more 80.41(n)
    91.24(a)
      431611  XM_429163.3  XP_429163.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNA146
    guanine nucleotide binding protein (G protein), al...
    75(a)
    1 ↔ 1
    2(45673405-45714532)
    African clawed frog
    (Xenopus laevis)
    Amphibia Gna142 G protein alpha subunit 14 80.28(n)    AF059182.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gna14a1 guanine nucleotide binding protein (G protein), alpha more 69.68(n)
    75.71(a)
      556160  XM_678897.3  XP_683989.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Galpha49B3 phospholipase C activation
    heterotrimeric G-protein more
    72(a)
    (best of 2)
      49B8   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-13 guanine nucleotide-binding protein 45(a)
    (best of 5)
      V(11177163-11180155)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA26
    Nucleotide binding alpha subunit of the heterotrim...
    32(a)
    1 → many
    V(195168-196517) YER020W


    ENSEMBL Gene Tree for GNA14 (if available)
    TreeFam Gene Tree for GNA14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNA14 gene
    GNAQ2  GNA112  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  GNA122  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    17 SIMAP similar genes for GNA14 using alignment to 2 protein entries:     GNA14_HUMAN (see all proteins):
    GNA11    GNAQ    GNAI2    GNA15    GNAT3    GNAI1
    GNAI3    GNAT1    GNAT2    GNAO1    GNA13    GNAZ
    GNA12    GNAL    GNAS    GSA    WUGSC

    GNA14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNA14 (see all 5308)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341583121,2
    C--80011594(+) TCAGA-/TTT/TTTTTTTTT
    TT
    /TTTTTTTTTTTT
    TTTTT
    3 -- int1 cds10--------
    rs1820941581,2
    C--80037660(+) CCAACC/TGAGGT 1 -- ds50010--------
    rs1485448321,2
    C--80037707(+) CCTTAA/CGTCCC 1 -- ds50010--------
    rs1427931171,2
    --80037865(+) GATGCA/GCAGAC 1 -- ds50010--------
    rs1476689091,2
    C--80037909(+) CGAGTC/TACTAT 1 -- ds50010--------
    rs21488841,2
    C,F,H--80038022(+) TAGCCT/ACCTCA 1 -- ut31 ese36Minor allele frequency- A:0.05NS EA WA 540
    rs1422332711,2
    C--80038063(+) AAATCC/TGTGGT 1 -- ut310--------
    rs343837761,2
    C--80038177(+) AATGT-/ACACACA 1 -- ut310--------
    rs11625981,2
    C,H--80038192(+) ACACGC/TGCACA 1 -- ut31 ese313Minor allele frequency- T:0.02MN NA WA CSA EA 560
    rs10562881,2
    C,F,H--80038196(+) GTGCAC/GACACA 1 -- ut31 ese37Minor allele frequency- G:0.26EA MN NA 1916

    HapMap Linkage Disequilibrium report for GNA14 (80037995 - 80263232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GNA14 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671344CNV Deletion23128226
    esv2738610CNV Deletion23290073
    esv2669994CNV Deletion23128226
    esv2562696CNV Insertion19546169
    esv2463816CNV Insertion19546169
    esv271163CNV Insertion20981092
    esv21709CNV Loss19812545
    esv26092CNV Loss19812545
    nsv893486CNV Loss21882294
    nsv893485CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNA14
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604397    OMIM disorders: --

    14 diseases for GNA14:    
    About MalaCards
    pertussis    chorea-acanthocytosis    acanthocytosis    chorea
    fainting    uterine fibroid    trypanosomiasis    chagas disease
    huntington's disease    hypertension    neuroblastoma    retinitis
    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for GNA14:
    chorea-acanthocytosis

    GNA14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNA14
    Human Genome Epidemiology (HuGE) Navigator: GNA14 (5 documents)

    Export disorders for GNA14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNA14 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with GNA14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human G-alpha-14 and G-alpha-Q genes and mutation analysis in chorea-acanthocytosis (CHAC). (PubMed id 10191087)1, 2, 3 Rubio J.P.... Monaco A.P. (Genomics 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PubMed id 18360038)1, 4 Kohara K....Miki T. (Hypertens. Res. 2008)
    5. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PubMed id 17620339)1, 3 Pedone K.H. and Hepler J.R. (J. Biol. Chem. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1. (PubMed id 22711498)1 Kwan D.H....Wong Y.H. (J. Cell. Biochem. 2012)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades. (PubMed id 19687291)1 Lee M.M. and Wong Y.H. (J. Leukoc. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9630 HGNC: 4382 AceView: GNA14 Ensembl:ENSG00000156049 euGenes: HUgn9630
    ECgene: GNA14 Kegg: 9630 H-InvDB: GNA14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNA14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNA14 gene:
    Search GeneIP for patents involving GNA14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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