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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNA14 Gene

protein-coding GIFtS: 61
GCID: GC09M080037

guanine nucleotide binding protein (G protein), alpha 14

Explore 14 diseases affiliated with
GNA14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 14¹ ²
G Alpha-14² ³
G-Protein Subunit Alpha-14² ³
Guanine Nucleotide-Binding Protein 14²
Guanine Nucleotide-Binding Protein Subunit Alpha-14²

External Ids:	HGNC: 4382¹	Entrez Gene: 9630²	Ensembl: ENSG00000156049⁷	OMIM: 604397⁵	UniProtKB: O95837³

Export aliases for GNA14 gene to outside databases

Previous GC identifers: GC09M071085 GC09M071894 GC09M073607 GC09M075495 GC09M077268 GC09M079227 GC09M049869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNA14:

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers

consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more

specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant

activation of phospholipase C-beta and its downstream effectors.(provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems

summary for GNA14:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates

PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNA14 gene promoter:
Nkx3-1 Nkx3-1 v4 ISGF-3 AML1a FOXD3 Nkx3-1 v1 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNA14 promoter sequence

Search SABiosciences Chromatin IP Primers for GNA14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21 Ensembl cytogenetic band: 9q21.2 HGNC cytogenetic band: 9q21

GNA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA14 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M080037: view genomic region (about GC identifiers)

Start:	80,037,995 bp from pter	End:	80,263,232 bp from pter
Size:	225,238 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein subunit alpha-14

Size: 355 amino acids; 41571 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide

binding site

Explore the universe of human proteins at neXtProt for GNA14: NX_O95837

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95837

GNA14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004288.1

ENSEMBL proteins:

ENSP00000365807

Reactome Protein details: O95837
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005834	heterotrimeric G-protein complex	IBA	--
GO:0005886	plasma membrane	TAS	--
GO:0031234	extrinsic to internal side of plasma membrane	IBA	--

GNA14 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNA14 for domains About GeneDecksing

3 InterPro domains/families:

IPR001019 Gprotein_alpha_su

IPR000654 Gprotein_alpha_Q

IPR011025 GproteinA_insert

Graphical View of Domain Structure for InterPro Entry O95837

ProtoNet protein and cluster: O95837

2 Blocks protein families:

IPB000654 G-protein alpha subunit group Q signature

IPB001019 Alpha G-protein (transducin) signature

UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837

Similarity: Belongs to the G-alpha family. G(q) subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GNA14_HUMAN, O95837

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems

Genatlas biochemistry entry for GNA14:

guanine nucleotide binding protein (G protein),alpha 14,expressed in fetal lung,kidney,liver,mediating pertussis

toxin-resistant stimulation of phospholipase C beta

miRNA Products:		OriGene 3'-UTR Clone: GNA14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA14
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA14:
		hsa-miR-124 hsa-miR-506
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNA14

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA14

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IBA	--
GO:0003924	GTPase activity	TAS	10191087
GO:0004871	signal transducer activity	IBA	--
GO:0005525	GTP binding	IEA	--
GO:0031683	G-protein beta/gamma-subunit complex binding	IBA	--

GNA14 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for GNA14:

Decreased Salmonella enterica

Decreased viability

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/43 super-pathways (see all 43) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-Beta Gamma Signaling

G-Beta Gamma Signaling	1.00	Relaxin Pathway	0.32
GHRH Signaling	0.46	Hedgehog Signaling in Mammals	0.22
CRHR Pathway	0.44

CCR3 Pathway in Eosinophils

CCR3 Pathway in Eosinophils	1.00	CXCR4 Pathway	0.39
VEGF and S-1P Signaling	0.44	Huntington's Disease Pathway	0.18
fMLP Pathway	0.43

Thromboxane signalling through TP receptor

	Thromboxane signalling through TP receptor	1.00			Signal amplification	0.74
	ADP signalling through P2Y purinoceptor 1	0.78			Thrombin signalling through proteinase activated receptors (PARs)	0.67

Regulation of Insulin Secretion by Free Fatty Acids

	Regulation of Insulin Secretion by Free Fatty Acids	1.00			Regulation of Insulin Secretion by Acetylcholine	0.64
	Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)	1.00			P2Y purinoceptor 1 activates MAP kinase p38 alpha	0.44

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GNA14

Development Activation of ERK by Alpha-1 adrenergic receptors

5/60 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA14 (see all 60)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	CDK5 Pathway
	ERK5 Signaling

1 GeneGo (Thomson Reuters) Pathway for GNA14

Development Activation of ERK by Alpha-1 adrenergic receptors

5/6 BioSystems Pathways for GNA14 (see all 6)

	G Protein Signaling Pathways
	S1P3 pathway
	Arf6 signaling events
	S1P2 pathway
	Sphingosine 1-phosphate (S1P) pathway

5/18 Reactome Pathways for GNA14 (see all 18)

	Metabolism
	Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
	Regulation of Insulin Secretion
	Regulation of Insulin Secretion by Free Fatty Acids
	Regulation of Insulin Secretion by Acetylcholine

3 Kegg Pathways (Kegg details for GNA14):

	Calcium signaling pathway
	Chagas disease (American trypanosomiasis)
	Amoebiasis

GNA14 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GNA14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/739 Interacting proteins for GNA14 (O95837^{2, 3} ENSP00000365807⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 739)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHRM2	P08172³, ENSP00000319984⁴	I2D: score=1 STRING: ENSP00000319984
OPRL1	P41146³, ENSP00000336764⁴	I2D: score=1 STRING: ENSP00000336764
CCR1	P32246³, ENSP00000296140⁴	I2D: score=1 STRING: ENSP00000296140
CXCR1	P25024³, ENSP00000295683⁴	I2D: score=1 STRING: ENSP00000295683
CXCR2	P25025³, ENSP00000319635⁴	I2D: score=1 STRING: ENSP00000319635

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	10191087
GO:0006471	protein ADP-ribosylation	IEA	--
GO:0007165	signal transduction	TAS	10191087
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA	--
GO:0007596	blood coagulation	TAS	--

GNA14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNA14 available from Tocris Bioscience About this table

Compound	Action	CAS #
Mastoparan X	G protein activator peptide	[72093-22-2]
G-Protein antagonist peptide	Inhibits G protein activation by GPCRs	[143675-79-0]

3 HMDB Compounds for GNA14 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNA14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNA14 gene:

NM_004297.3

Unigene Cluster for GNA14:

Guanine nucleotide binding protein (G protein), alpha 14

Hs.657795 [show with all ESTs]

Unigene Representative Sequence: NM_004297

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341700(uc004aku.3) ENST00000464095

miRNA Products:		OriGene 3'-UTR Clone: GNA14 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA14
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA14:
		hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: GNA14 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: GNA14 (NM_004297)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA14

Additional cDNA sequence:

AF105201.1 AF493903.1 AK312460.1 BC027886.1

6 DOTS entries:

DT.70105382 DT.100700606 DT.95074990 DT.121212078 DT.97825328 DT.91935462

24/30 AceView cDNA sequences (see all 30):

AF493903 AF105201 BC027886 NM_004297 CR595826 BI489883 CD299466 BX333156

BI838805 AI629022 BP370141 AI685379 AI800090 BI761212 BV174904 BG545383

AI263118 BI832845 AA603929 AI264963 BQ026199 BX333157 N75416 CD299264

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNA14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCAAAGA

About this image

GNA14 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Cartilage

Kidney

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Primordial germ cell-like cells (Reconstitution of mo...)

Matrigel embedded cells (Derivation of cardio...)

See GNA14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNA14

SOURCE GeneReport for Unigene cluster: Hs.657795

SABiosciences Custom PCR Arrays for GNA14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA14 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNA14 gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNA14¹	guanine nucleotide binding protein (G protein), alpha more	80.29(n) 91.43(a)		431611 XM_429163.2 XP_429163.2
lizard (Anolis carolinensis)	Reptilia	GNA14⁶	--	84(a)	1 ↔ 1	2(45697992-45714532)
African clawed frog (Xenopus laevis)	Amphibia	Gna14²	G protein alpha subunit 14	80.28(n)		AF059182.1
zebrafish (Danio rerio)	Actinopterygii	LOC556160¹	guanine nucleotide-binding protein subunit alpha-14-like	69.68(n) 75.71(a)		556160 XM_678897.2 XP_683989.2
worm (Caenorhabditis elegans)	Secernentea	gpa-1³	guanine nucleotide-binding protein	45(a) (best of 5)		V(11177163-11180155) --
thale cress (Arabidopsis thaliana)	eudicotyledons	XLG1⁶ XLG3⁶ (see all 4)	extra-large GTP-binding protein 3 (see all 4)	9(a) 9(a) (see all 4)	many ↔ many many ↔ many (see all 4)	2(9995478-9999122) 1(11464985-11469185)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	G-protein alpha subunit, putative, expressed (see all 5)	9(a) 9(a) (see all 5)	many ↔ many many ↔ many (see all 5)	12(24838937-24843804) 6(633143-639480)

ENSEMBL Gene Tree for GNA14 (if available)
TreeFam Gene Tree for GNA14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNA14 gene

GNAQ² GNA11² GNAI3² GNAT2² GNA13² GNAT3² GNAT1² GNAI2²

GNA15² GNA12² GNAZ² GNAO1² GNAI1²

17 SIMAP similar genes for GNA14 using alignment to 2 protein entries: GNA14_HUMAN (see all proteins):

GNA11 GNAQ GNAI2 GNA15 GNAT3 GNAI1

GNAI3 GNAT1 GNAT2 GNAO1 GNA13 GNAZ

GNA12 GNAL GNAS GSA WUGSC

GNA14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182094158^1,2		--	80037660(+)	`CCAACC/TGAGGT`	1	--	ds500¹		0	--	--	--	--
rs148544832^1,2	C,	--	80037707(+)	`CCTTAA/CGTCCC`	1	--	ds500¹		0	--	--	--	--
rs142793117^1,2		--	80037865(+)	`GATGCA/GCAGAC`	1	--	ds500¹		0	--	--	--	--
rs147668909^1,2		--	80037909(+)	`CGAGTC/TACTAT`	1	--	ds500¹		0	--	--	--	--
rs2148884^1,2	C,F,H,	--	80038022(+)	`TAGCCT/ACCTCA`	1	--	ut3¹ ese³		6		NS EA WA	540
rs142233271^1,2		--	80038063(+)	`AAATCC/TGTGGT`	1	--	ut3¹		0	--	--	--	--
rs34383776^1,2	C,	--	80038177(+)	`AATGT-/ACACACA`	1	--	ut3¹		0	--	--	--	--
rs1162598^1,2	C,H,	--	80038192(+)	`ACACGC/TGCACA`	1	--	ut3¹ ese³		13		MN NA WA CSA EA	560
rs1056288^1,2	C,F,H,	--	80038196(+)	`GTGCAC/GACACA`	1	--	ut3¹ ese³		7		EA MN NA	1916
rs146197945^1,2		--	80038222(+)	`TAAAAC/TATATA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GNA14 (80037995 - 80263232 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GNA14
     2 CNVs: 65428 70735
     2 Indels: 100676 100677
     1 Inversion: 59870

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNA14 for disorders           About GeneDecksing

OMIM gene information: 604397    OMIM disorders: --

14 diseases for GNA14:    About MalaCards

pertussis acanthocytosis chorea fainting

chagas disease trypanosomiasis thrombosis hypertension

neuroblastoma pancreatitis neuronitis huntington's disease

breast cancer retinitis

1 disease from the University of Copenhagen DISEASES database for GNA14:

chorea-acanthocytosis

Human Genome Epidemiology (HuGE) Navigator: GNA14 (5 documents)

Export disorders for GNA14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNA14 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with GNA14)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization of the human G-alpha-14 and G-alpha-Q genes and mutation analysis in chorea-acanthocytosis (CHAC). (PubMed id 10191087)^{1, 2, 3} Rubio J.P.... Monaco A.P. (1999)
The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. (PubMed id 17620339)^{1, 3} Pedone K.H. and Hepler J.R. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Activation of Ras-dependent signaling pathways by G(14 ) -coupled receptors requires the adaptor protein TPR1. (PubMed id 22711498)¹ Kwan D.H....Wong Y.H. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galph a(16) signaling cascades. (PubMed id 19687291)¹ Lee M.M. and Wong Y.H. (2009)
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PubMed id 18360038)¹ Kohara K....Miki T. (2008)
Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)¹ Luttrell L.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9630	HGNC: 4382	AceView: GNA14	Ensembl:ENSG00000156049	euGenes: HUgn9630
ECgene: GNA14	Kegg: 9630	H-InvDB: GNA14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNA14	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GNA14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GNA14 gene:
Search GeneIP for patents involving GNA14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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guanine nucleotide binding protein (G protein), alpha 14

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GNA14 Gene

guanine nucleotide binding protein (G protein), alpha 14

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