Aliases for GNA14 Gene
External Ids for GNA14 Gene
Previous GeneCards Identifiers for GNA14 Gene
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
GeneCards Summary for GNA14 Gene
GNA14 (Guanine Nucleotide Binding Protein (G Protein), Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include pertussis. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNA14 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.