Aliases for GNA14 Gene
External Ids for GNA14 Gene
Previous GeneCards Identifiers for GNA14 Gene
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
GeneCards Summary for GNA14 Gene
GNA14 (G Protein Subunit Alpha 14) is a Protein Coding gene. Diseases associated with GNA14 include Kaposiform Hemangioendothelioma and Angioma, Tufted. Among its related pathways are CCR5 Pathway in Macrophages and Phospholipase-C Pathway. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNA11.
UniProtKB/Swiss-Prot for GNA14 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.