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Aliases for GNA13 Gene

Aliases for GNA13 Gene

  • G Protein Subunit Alpha 13 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Alpha 13 2 3
  • G Alpha-13 3 4
  • Guanine Nucleotide-Binding Protein Subunit Alpha-13 3
  • G-Protein Subunit Alpha-13 4
  • G13 3

External Ids for GNA13 Gene

Previous GeneCards Identifiers for GNA13 Gene

  • GC17P065359
  • GC17P068426
  • GC17M063424
  • GC17M063556
  • GC17M063555
  • GC17M060437
  • GC17M063005
  • GC17M058399

Summaries for GNA13 Gene

GeneCards Summary for GNA13 Gene

GNA13 (G Protein Subunit Alpha 13) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and ADP signalling through P2Y purinoceptor 1. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNA12.

UniProtKB/Swiss-Prot for GNA13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Tocris Summary for GNA13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNA13 Gene

Additional gene information for GNA13 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA13 Gene

Genomics for GNA13 Gene

Regulatory Elements for GNA13 Gene

Enhancers for GNA13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H064983 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.3 +71.5 71468 4 HDGF PKNOX1 FOXA2 ATF1 ZBTB7B ZNF143 ZNF207 FOS ATF7 RUNX3 AMZ2P1 GNA13 DDX5 CEP95 RGS9 LRRC37A3 GC17P064985
GH17H065021 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.9 +33.6 33569 2 HDGF PKNOX1 FOXA2 FEZF1 BATF RAD21 ZNF366 ZSCAN5C FOS ATF7 GNA13 RGS9 ARHGAP27P1-BPTFP1-KPNA2P3 ENSG00000266598 GC17P064985
GH17H064988 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +67.8 67832 2 SUZ12 ZIC2 FOSL1 ZNF121 SCRT2 FOSL2 FOS ATF7 SCRT1 ZNF687 AMZ2P1 GNA13 DDX5 CEP95 GC17P064985 ENSG00000266598
GH17H064990 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +65.8 65806 0 ELF3 TBP HLF CEBPB CEBPG YBX1 HMG20A THRB RARA NFIL3 GNA13 AMZ2P1 DDX5 GC17P064985 ENSG00000266598
GH17H065047 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.1 +8.6 8558 2 PKNOX1 MAFG MAX ELF1 GABPA YY1 ZFHX2 ZNF316 MAFF MLLT1 GNA13 RGS9 ENSG00000266598 GC17P064985
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNA13 on UCSC Golden Path with GeneCards custom track

Promoters for GNA13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000097069 839 2801 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 ZNF143 ZNF207 SP3

Genomic Location for GNA13 Gene

Chromosome:
17
Start:
65,009,289 bp from pter
End:
65,056,839 bp from pter
Size:
47,551 bases
Orientation:
Minus strand

Genomic View for GNA13 Gene

Genes around GNA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA13 Gene

Proteins for GNA13 Gene

  • Protein details for GNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14344-GNA13_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-13
    Protein Accession:
    Q14344
    Secondary Accessions:
    • B2R977
    • B7Z7R0
    • F5H1G8
    • Q8TD70

    Protein attributes for GNA13 Gene

    Size:
    377 amino acids
    Molecular mass:
    44050 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma (PubMed:12399457). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts with HAX1 (PubMed:15339924). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (in GTP-bound form) with ARHGEF1 (PubMed:10747909). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164). Interacts with CTNND1 (PubMed:15240885).

    Alternative splice isoforms for GNA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNA13 Gene

Post-translational modifications for GNA13 Gene

  • Palmitoylation is critical for proper membrane localization and signaling.
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.
  • Ubiquitination at isoforms=2214 and posLast=372372
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA13 Gene

No data available for DME Specific Peptides for GNA13 Gene

Domains & Families for GNA13 Gene

Gene Families for GNA13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GNA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14344

UniProtKB/Swiss-Prot:

GNA13_HUMAN :
  • Belongs to the G-alpha family. G(12) subfamily.
Family:
  • Belongs to the G-alpha family. G(12) subfamily.
genes like me logo Genes that share domains with GNA13: view

Function for GNA13 Gene

Molecular function for GNA13 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Phenotypes From GWAS Catalog for GNA13 Gene

Gene Ontology (GO) - Molecular Function for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity IBA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with GNA13: view
genes like me logo Genes that share phenotypes with GNA13: view

Animal Models for GNA13 Gene

MGI Knock Outs for GNA13:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNA13
  • Applied Biological Materials Clones for GNA13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNA13 Gene

Localization for GNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNA13 Gene

Cell membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:18703424}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNA13 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNA13: view

Pathways & Interactions for GNA13 Gene

genes like me logo Genes that share pathways with GNA13: view

SIGNOR curated interactions for GNA13 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006928 movement of cell or subcellular component TAS 8999798
GO:0007165 signal transduction TAS 7791744
genes like me logo Genes that share ontologies with GNA13: view

Drugs & Compounds for GNA13 Gene

(3) Drugs for GNA13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for GNA13 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNA13 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNA13: view

Transcripts for GNA13 Gene

mRNA/cDNA for GNA13 Gene

Unigene Clusters for GNA13 Gene

Guanine nucleotide binding protein (G protein), alpha 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNA13
  • Applied Biological Materials Clones for GNA13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GNA13 Gene

No ASD Table

Relevant External Links for GNA13 Gene

GeneLoc Exon Structure for
GNA13
ECgene alternative splicing isoforms for
GNA13

Expression for GNA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNA13 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for GNA13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNA13 Gene



Protein tissue co-expression partners for GNA13 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNA13 Gene:

GNA13

SOURCE GeneReport for Unigene cluster for GNA13 Gene:

Hs.515018

mRNA Expression by UniProt/SwissProt for GNA13 Gene:

Q14344-GNA13_HUMAN
Tissue specificity: Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).

Evidence on tissue expression from TISSUES for GNA13 Gene

  • Nervous system(4.8)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with GNA13: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNA13 Gene

Orthologs for GNA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNA13 33 34
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia GNA13 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNA13 34 33
  • 92.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gna13 33
  • 91.25 (n)
mouse
(Mus musculus)
Mammalia Gna13 33 16 34
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia GNA13 34 33
  • 86.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNA13 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNA13 33 34
  • 85.5 (n)
lizard
(Anolis carolinensis)
Reptilia GNA13 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145489 33
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii gna13b 34
  • 84 (a)
OneToMany
gna13a 33 34
  • 74.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009457 33
  • 58.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta cta 33 34 35
  • 55.62 (n)
CG40005 34
  • 55 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gpa-12 35 34
  • 49 (a)
gpa-14 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
OneToMany
Species where no ortholog for GNA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA13 Gene

ENSEMBL:
Gene Tree for GNA13 (if available)
TreeFam:
Gene Tree for GNA13 (if available)

Paralogs for GNA13 Gene

Paralogs for GNA13 Gene

(18) SIMAP similar genes for GNA13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GNA13 Gene

genes like me logo Genes that share paralogs with GNA13: view

Variants for GNA13 Gene

Sequence variations from dbSNP and Humsavar for GNA13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000022849 -- 65,034,434(+) GCTGG(A/G)ACTAC intron-variant
rs1000027528 -- 65,052,395(+) GTGAT(C/T)CACCC intron-variant
rs1000046497 -- 65,024,733(+) CCCTC(A/G)CATTA intron-variant
rs1000051636 -- 65,058,470(+) CTGTG(G/T)ATTGA upstream-variant-2KB
rs1000094801 -- 65,041,239(+) AAAGA(A/C)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNA13 Gene

Variant ID Type Subtype PubMed ID
nsv1066765 CNV gain 25217958
nsv1120054 OTHER inversion 24896259
nsv112105 CNV deletion 16902084
nsv2123 CNV insertion 18451855
nsv478515 CNV novel sequence insertion 20440878
nsv952361 CNV duplication 24416366

Variation tolerance for GNA13 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA13 Gene

Disorders for GNA13 Gene

Relevant External Links for GNA13

Genetic Association Database (GAD)
GNA13
Human Genome Epidemiology (HuGE) Navigator
GNA13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNA13

No disorders were found for GNA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNA13 Gene

Publications for GNA13 Gene

  1. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PMID: 12515866) Suzuki N … Kozasa T (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 60
  2. Expression of GTP-binding protein alpha subunits in human thymocytes. (PMID: 7791744) Kabouridis PS … Tsoukas CD (Molecular and cellular biochemistry 1995) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y … Sha J (Biology of reproduction 2008) 3 4 60
  5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 60

Products for GNA13 Gene

  • Addgene plasmids for GNA13

Sources for GNA13 Gene

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