Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNA13 Gene

protein-coding   GIFtS: 62
GCID: GC17M063005

Guanine Nucleotide Binding Protein (G Protein), Alpha 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 131 2
G Alpha-132 3
G-Protein Subunit Alpha-132 3
G132
Guanine Nucleotide-Binding Protein Subunit Alpha-132

External Ids:    HGNC: 43811   Entrez Gene: 106722   Ensembl: ENSG000001200637   OMIM: 6044065   UniProtKB: Q143443   

Export aliases for GNA13 gene to outside databases

Previous GC identifers: GC17P065359 GC17P068426 GC17M063424 GC17M063556 GC17M063555 GC17M060437 GC17M058399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GNA13 Gene: 
GNA13 (guanine nucleotide binding protein (G protein), alpha 13) is a protein-coding gene. Diseases associated with GNA13 include fainting, and azoospermia, and among its related super-pathways are Regulation of actin cytoskeleton and GHRH Signaling. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNA13 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved
in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including
cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNA13 gene promoter:
         Max1   C/EBPalpha   CREB   S8   IRF-2   Nkx6-1   deltaCREB   Msx-1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNA13 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNA13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.3   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q24

GNA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M063005:  view genomic region     (about GC identifiers)

Start:
63,005,407 bp from pter      End:
63,052,957 bp from pter
Size:
47,551 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-13  
Size: 377 amino acids; 44050 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with UBXD5. Interacts with HAX1
Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
Secondary accessions: B2R977 Q8TD70

Explore the universe of human proteins at neXtProt for GNA13: NX_Q14344

Explore proteomics data for GNA13 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation is critical for proper membrane localization and signaling
  • UniProtKB: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho
    activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14344

  • GNA13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNA13 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269354.1  NP_006563.2  

    ENSEMBL proteins: 
     ENSP00000400717   ENSP00000439647  
    Reactome Protein details: Q14344
    Human Recombinant Protein Products for GNA13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GNA13
    GenScript Custom Purified and Recombinant Proteins Services for GNA13
    Novus Biologicals GNA13 Protein
    Novus Biologicals GNA13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic to internal side of plasma membrane IBA--
    GO:0031526brush border membrane IBA--
    GO:0042470melanosome IEA--

    GNA13 for ontologies           About GeneDecksing



    GNA13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GNA13
    OriGene Custom Antibody Services for GNA13
    GenScript Custom Superior Antibodies Services for GNA13
    Novus Biologicals GNA13 Antibodies
    Abcam antibodies for GNA13
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for GNA13
    LSBio Antibodies in human, mouse, rat for GNA13 

    Assay Products for GNA13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GNA13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNA13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR027417 P-loop_NTPase
     IPR000469 Gprotein_alpha_12

    Graphical View of Domain Structure for InterPro Entry Q14344

    ProtoNet protein and cluster: Q14344

    2 Blocks protein domains:
    IPB000469 G-protein alpha subunit group 12 signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Similarity: Belongs to the G-alpha family. G(12) subfamily


    GNA13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNA13_HUMAN, Q14344
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding ----
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI10026210
    GO:0005525GTP binding IEA--
         
    GNA13 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gna13):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     nervous system  no phenotypic analysis  normal 

    GNA13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GNA13: Gna13tm1Soff Gna13tm2.1Cgh Gna13tm2.2Soff

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNA13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNA13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNA13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNA13 

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNA13:
    hsa-mir-155 (MIRT001546)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA13
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA13 (see all 92):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidGNA13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GNA13
    Sirion Biotech Customized adenovirus for overexpression of GNA13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GNA13 (see all 5)
    OriGene ORF clones in mouse, rat for GNA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNA13 (NM_006572)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13
    Sirion Biotech Customized lentivirus for stable overexpression of GNA13 
                         Customized lentivirus expression plasmids for stable overexpression of GNA13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GNA13
    Search LifeMap BioReagents cell lines for GNA13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNA13 About   (see all 52)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    Relaxin Pathway0.37
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.32
    CRHR Pathway0.44
    3fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.30
    fMLP Pathway0.43
    4GPCR Pathway
    GPCR Pathway0.62
    NFAT in Immune Response0.58
    Breast Cancer Regulation by Stathmin10.58
    Estrogen Pathway0.55
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for GNA13 (see all 8)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling M-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    G-protein signaling G-Protein alpha-12 signaling pathway
    Signal transduction PKA signaling

    5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA13 (see all 63)
        Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    JNK Pathway

    5/8 GeneGo (Thomson Reuters) Pathways for GNA13 (see all 8)
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Signal transduction PKA signaling
    Development G-Proteins mediated regulation MARK-ERK signaling
    Cell adhesion Integrin inside-out signaling

    5/11 BioSystems Pathways for GNA13 (see all 11)
        G13 Signaling Pathway
    G Protein Signaling Pathways
    Regulation of Actin Cytoskeleton
    TSH signaling pathway
    Plasma membrane estrogen receptor signaling

    5/9        Reactome Pathways for GNA13 (see all 9)
        GPCR downstream signaling
    Hemostasis
    G alpha (12/13) signalling events
    Signal amplification
    Signal Transduction

    1 PharmGKB Pathway for GNA13
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for GNA13):
        Vascular smooth muscle contraction
    Long-term depression
    Regulation of actin cytoskeleton


    GNA13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNA13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for GNA13 (Q143441, 2, 3 ENSP000004007174) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF1Q928881, 2, 3, ENSP000003372614EBI-465387,EBI-465400 MINT-7909440 I2D: score=4 STRING: ENSP00000337261
    AKAP3O759693, ENSP000002288504I2D: score=3 STRING: ENSP00000228850
    ARHGEF11O150853, ENSP000003571774I2D: score=3 STRING: ENSP00000357177
    CDH1P128303, ENSP000002617694I2D: score=3 STRING: ENSP00000261769
    CDH2P190223, ENSP000002691414I2D: score=3 STRING: ENSP00000269141
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001569patterning of blood vessels IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006928cellular component movement TAS8999798
    GO:0007165signal transduction TAS7791744

    GNA13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNA13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNA13 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNA13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for GNA13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 42.6 2 10318854 (1)

    Search CenterWatch for drugs/clinical trials and news about GNA13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNA13 gene (2 alternative transcripts): 
    NM_001282425.1  NM_006572.5  

    Unigene Cluster for GNA13:

    Guanine nucleotide binding protein (G protein), alpha 13
    Hs.515018  [show with all ESTs]
    Unigene Representative Sequence: NM_006572
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439174(uc010wqh.2 uc002jfc.3) ENST00000541118
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA13
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA13 (see all 92):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidGNA13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13
    Clone
    Products:
         
    OriGene clones in human, mouse for GNA13 (see all 5)
    OriGene ORF clones in mouse, rat for GNA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GNA13 (NM_006572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13
    Sirion Biotech Customized lentivirus for stable overexpression of GNA13 
                         Customized lentivirus expression plasmids for stable overexpression of GNA13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GNA13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNA13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13

    Additional mRNA sequence: 

    AB075500.1 AF493902.1 AK002117.1 AK026902.1 AK301699.1 AK302400.1 AK313672.1 BC011925.1 
    BC036756.1 BX647930.1 L22075.1 

    7 DOTS entries:

    DT.452138  DT.92434397  DT.100792846  DT.101971191  DT.95272504  DT.100663740  DT.92434399 

    24/244 AceView cDNA sequences (see all 244):

    CR611712 F13305 AA418765 BQ929548 CD366224 AK002117 D63014 F09625 
    AW130618 AU138594 BU183024 BI772233 AA418721 AA298148 BG252372 BU166826 
    BX479255 BP872872 AF493902 BQ720684 BI830443 BM828172 AK026902 BC036756 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNA13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAAAGC
    GNA13 Expression
    About this image


    See GNA13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNA13

    SOURCE GeneReport for Unigene cluster: Hs.515018
        SABiosciences Custom PCR Arrays for GNA13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GNA13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNA13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNA13 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gna131 , 5 guanine nucleotide binding protein, alpha 131, 5 90.72(n)1
    96.82(a)1
      11 (71.88 cM)5
    146741  NM_010303.31  NP_034433.31 
     1093628315 
    chicken
    (Gallus gallus)
    Aves GNA131 guanine nucleotide binding protein (G protein), alpha more 85.5(n)
    92.04(a)
      417434  XM_415686.3  XP_415686.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNA136
    Uncharacterized protein
    90(a)
    1 ↔ 1
    GL343260.1(1398524-1428679)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF549941.12   -- 78.42(n)    AF549941.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD052686.12   -- 76.22(n)    CD052686.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cta1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    concertina1
    55(a)3
    55.62(n)1
    57.43(a)1
      2 40 (determined by in situ hybridization)3
    33551311  NM_001042956.11  NP_001036421.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-123 guanine nucleotide-binding protein 49(a)
    (best of 2)
      X(9282179-9283774)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA16
    GTP-binding alpha subunit of the heterotrimeric G ...
    27(a)
    1 → many
    VIII(113499-114917)


    ENSEMBL Gene Tree for GNA13 (if available)
    TreeFam Gene Tree for GNA13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNA13 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNAT32  GNAT12  GNA122  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNA13 using alignment to 2 protein entries:     GNA13_HUMAN (see all proteins):
    GNA12    GNA11    GNA14    GNAQ    GNAI3    GNAT3
    GNAI1    GNAO1    GNAI2    GNAT2    GNA15    DKFZp686O0962
    GNAT1    GNAZ    GNAS    GNAL    GSA    WUGSC

    GNA13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GNA13
    PGOHUM00000263080


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/869 SNPs in GNA13 are shown (see all 869)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821070561,2
    --58397924(+) CTACGA/GGAACT 1 -- ds50010--------
    rs1463847061,2
    C--58397929(+) GGAAC-/TATTATAA 1 -- ds50010--------
    rs1870667501,2
    --58397945(+) GTGTGC/GAGTAT 1 -- ds50010--------
    rs110795461,2
    C,F,A,H--58398071(+) CAGACC/GTAACA 1 -- ds500116Minor allele frequency- G:0.26NS EA NA WA CSA 694
    rs1910072911,2
    --58398115(+) AGCTCA/GGGTAC 1 -- ds50010--------
    rs1443822151,2
    C--58398438(+) TAAATA/GTCAGT 1 -- ut310--------
    rs561664451,2
    C--58398472(+) TAGCAA/GGAGGC 1 -- ut310--------
    rs1152954311,2
    F--58398475(+) CAAGAG/AGCAAA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1177448091,2
    C,F--58398592(+) ATTGCC/TCATCC 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1511904021,2
    C--58398678(+) ATATAC/TGTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GNA13 (63005407 - 63052957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNA13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2123CNV Insertion18451855
    nsv112105CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GNA13
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604406    OMIM disorders: --

    11 diseases for GNA13:    About MalaCards
    fainting    azoospermia    huntington's disease    astrocytoma
    endotheliitis    retinitis    lung cancer    prostate cancer
    prostatitis    breast cancer    leukemia


    GNA13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GNA13
    Human Genome Epidemiology (HuGE) Navigator: GNA13 (3 documents)

    Export disorders for GNA13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNA13 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with GNA13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of GTP-binding protein alpha subunits in human thymocytes. (PubMed id 7791744)1, 2, 3 Kabouridis P.S.... Tsoukas C.D. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. (PubMed id 12399457)1, 2 Manganello J.M....Le Breton G.C. (2003)
    7. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)1, 2 Bhattacharyya R. and Wedegaertner P.B. (2000)
    8. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. (PubMed id 15735747)1, 9 Grabocka E. and Wedegaertner P.B. (2005)
    9. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PubMed id 12515866)1, 9 Suzuki N....Kozasa T. (2003)
    10. Galpha12 and galpha13 are phosphorylated during platelet activation. (PubMed id 8824244)1, 9 Offermanns S....Simon M.I. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10672 HGNC: 4381 AceView: GNA13 Ensembl:ENSG00000120063 euGenes: HUgn10672
    ECgene: GNA13 Kegg: 10672 H-InvDB: GNA13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNA13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNA13 gene:
    Search GeneIP for patents involving GNA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GNA13   OriGene RNAi products in human, mouse, rat for GNA13  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GNA13  
     OriGene qSTAR qPCR primer pairs in human, mouse for GNA13   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GNA13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNA13   OriGene Custom Protein Services for GNA13  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNA13
     QIAGEN SeqTarget long-range PCR primers for resequencing GNA13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
     GenScript Custom Purified and Recombinant Proteins Services for GNA13 GenScript cDNA clones with any tag delivered in your preferred vector for GNA13
     GenScript Custom Assay Services for GNA13 GenScript Custom Superior Antibodies Services for GNA13
     GenScript Custom overexpressing Cell Line Services for GNA13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GNA13 promoter
     Search Chromatin IP Primers for GNA13
     RT2 qPCR Primer Assay in human, mouse, rat GNA13
     GNC Network for GNA13
     SABiosciences PCR Arrays including human, mouse, rat GNA13
     Tocris compounds for GNA13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GNA13 antibodies
     GNA13 proteins
     GNA13 lysates
     Antibodies for GNA13
     See all of Abcam's Antibodies, Kits and Proteins for GNA13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for GNA13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13
     SwitchGear 3'UTR luciferase reporter plasmids for GNA13
     SwitchGear Promoter luciferase reporter plasmids for GNA13
     Search ThermoFisher Antibodies for GNA13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GNA13
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNA13
    Customized:
     lentivirus for stable overexpression of GNA13
     lentivirus expression plasmids for stable overexpression of GNA13
     adenovirus for overexpression of GNA13
     LSBio Antibodies in human, mouse, rat for GNA13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GNA13 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4