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GNA13 Gene

protein-coding   GIFtS: 63
GCID: GC17M063005

Guanine Nucleotide Binding Protein (G Protein), Alpha 13

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 131 2
G Alpha-132 3
G-Protein Subunit Alpha-132 3
G132
Guanine Nucleotide-Binding Protein Subunit Alpha-132

External Ids:    HGNC: 43811   Entrez Gene: 106722   Ensembl: ENSG000001200637   OMIM: 6044065   UniProtKB: Q143443   

Export aliases for GNA13 gene to outside databases

Previous GC identifers: GC17P065359 GC17P068426 GC17M063424 GC17M063556 GC17M063555 GC17M060437 GC17M058399


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNA13 Gene:
GNA13 (guanine nucleotide binding protein (G protein), alpha 13) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNA13 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved
in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including
cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNA13 gene promoter:
         Max1   C/EBPalpha   CREB   S8   IRF-2   Nkx6-1   deltaCREB   Msx-1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNA13 promoter sequence
   Search Chromatin IP Primers for GNA13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.3   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q24

GNA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M063005:  view genomic region     (about GC identifiers)

Start:
63,005,407 bp from pter      End:
63,052,957 bp from pter
Size:
47,551 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-13  
Size: 377 amino acids; 44050 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Interacts (when active) with PPP5C (via TPR
repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane
Secondary accessions: B2R977 Q8TD70

Explore the universe of human proteins at neXtProt for GNA13: NX_Q14344

Explore proteomics data for GNA13 at MOPED

Post-translational modifications: 

  • Palmitoylation is critical for proper membrane localization and signaling1
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho
    activation1
  • Ubiquitination2 at Lys214, Lys372
  • Modification sites at PhosphoSitePlus

  • See GNA13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269354.1  NP_006563.2  

    ENSEMBL proteins: 
     ENSP00000400717   ENSP00000439647  
    Reactome Protein details: Q14344

    GNA13 Human Recombinant Protein Products:

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    Novus Biologicals GNA13 Protein
    Novus Biologicals GNA13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNA13 

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    LSBio Antibodies in human, mouse, rat for GNA13

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    Search eBioscience for ELISAs for GNA13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR027417 P-loop_NTPase
     IPR000469 Gprotein_alpha_12

    Graphical View of Domain Structure for InterPro Entry Q14344

    ProtoNet protein and cluster: Q14344

    2 Blocks protein domains:
    IPB000469 G-protein alpha subunit group 12 signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Similarity: Belongs to the G-alpha family. G(12) subfamily


    Find genes that share domains with GNA13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNA13_HUMAN, Q14344
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding ----
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI10026210
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with GNA13           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gna13):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with GNA13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GNA13: Gna13tm1Soff Gna13tm2.1Cgh Gna13tm2.2Soff

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNA13
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNA13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNA13

    miRNA
    Products:
        
    miRTarBase miRNAs that target GNA13:
    hsa-mir-100-5p (MIRT048395), hsa-mir-26b-5p (MIRT030064), hsa-mir-155-5p (MIRT001546), hsa-mir-30a-5p (MIRT028679), hsa-mir-1 (MIRT023990), hsa-mir-30b-5p (MIRT023441), hsa-mir-18a-3p (MIRT040886)

    Block miRNA regulation of human, mouse, rat GNA13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNA13 (see all 92):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidGNA13 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNA13

    Gene Editing
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    Sino Biological Human cDNA Clone for GNA13
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    Addgene plasmids for GNA13 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNA13_HUMAN, Q14344: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IBA--
    GO:0031526brush border membrane IBA--
    GO:0042470melanosome IEA--

    Find genes that share ontologies with GNA13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNA13 About   (see all 51)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    Relaxin Pathway0.37
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.32
    CRHR Pathway0.44
    3fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.30
    fMLP Pathway0.43
    4GPCR Pathway
    GPCR Pathway0.62
    NFAT in Immune Response0.58
    Breast Cancer Regulation by Stathmin10.58
    Estrogen Pathway0.55
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56


    Find genes that share SuperPaths with GNA13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNA13 (see all 63)
        Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    JNK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GNA13 (see all 8)
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Signal transduction PKA signaling
    Development G-Proteins mediated regulation MARK-ERK signaling
    Cell adhesion Integrin inside-out signaling

    Selected BioSystems Pathways for GNA13 (see all 11)
        G13 Signaling Pathway
    G Protein Signaling Pathways
    Regulation of Actin Cytoskeleton
    TSH signaling pathway
    LPA receptor mediated events


    3 Reactome Pathways for GNA13
        G alpha (12/13) signalling events
    Thromboxane signalling through TP receptor
    Thrombin signalling through proteinase activated receptors (PARs)

    1 PharmGKB Pathway for GNA13
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for GNA13):
        Vascular smooth muscle contraction
    Long-term depression
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNA13
    Interactions:

        GeneGlobe Interaction Network for GNA13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNA13 (Q143441, 2, 3 ENSP000004007174) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF1Q928881, 2, 3, ENSP000003372614EBI-465387,EBI-465400 MINT-7909440 I2D: score=4 STRING: ENSP00000337261
    AKAP3O759693, ENSP000002288504I2D: score=3 STRING: ENSP00000228850
    ARHGEF11O150853, ENSP000003571774I2D: score=3 STRING: ENSP00000357177
    CDH1P128303, ENSP000002617694I2D: score=3 STRING: ENSP00000261769
    CDH2P190223, ENSP000002691414I2D: score=3 STRING: ENSP00000269141
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    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001569patterning of blood vessels IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006928cellular component movement TAS8999798
    GO:0007165signal transduction TAS7791744

    Find genes that share ontologies with GNA13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNA13 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNA13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for GNA13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 42.6 2 10318854 (1)



    Find genes that share compounds with GNA13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNA13 gene (2 alternative transcripts): 
    NM_001282425.1  NM_006572.5  

    Unigene Cluster for GNA13:

    Guanine nucleotide binding protein (G protein), alpha 13
    Hs.515018  [show with all ESTs]
    Unigene Representative Sequence: NM_006572
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439174(uc010wqh.2 uc002jfc.3) ENST00000541118
    miRNA
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    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
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      QuantiTect SYBR Green Assays in human, mouse, rat GNA13
      QuantiFast Probe-based Assays in human, mouse, rat GNA13

    Additional mRNA sequence: 

    AB075500.1 AF493902.1 AK002117.1 AK026902.1 AK301699.1 AK302400.1 AK313672.1 BC011925.1 
    BC036756.1 BX647930.1 L22075.1 

    7 DOTS entries:

    DT.452138  DT.92434397  DT.100792846  DT.101971191  DT.95272504  DT.100663740  DT.92434399 

    Selected AceView cDNA sequences (see all 244):

    BI830443 BM828172 AK026902 BC036756 F13297 BM790882 BM464248 AL039816 
    AW130618 BI772233 AA418721 AV682718 AK002117 BQ929548 F13305 CD366224 
    AA418765 AF493902 AA298148 BG252372 BU166826 BX479255 BP872872 AU138594 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNA13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAAAGC
    GNA13 Expression
    About this image


    GNA13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    GNA13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNA13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515018
        Custom PCR Arrays for GNA13
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNA13 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gna131 , 5 guanine nucleotide binding protein, alpha 131, 5 90.72(n)1
    96.82(a)1
      11 (71.88 cM)5
    146741  NM_010303.31  NP_034433.31 
     1093628315 
    chicken
    (Gallus gallus)
    Aves GNA131 guanine nucleotide binding protein (G protein), alpha more 85.5(n)
    92.04(a)
      417434  XM_415686.4  XP_415686.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNA136
    guanine nucleotide binding protein (G protein), al...
    90(a)
    1 ↔ 1
    GL343260.1(1398524-1428679)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF549941.12   -- 78.42(n)    AF549941.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD052686.12   -- 76.22(n)    CD052686.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cta1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    concertina1
    55(a)3
    55.62(n)1
    57.43(a)1
      2 40 (determined by in situ hybridization)3
    33551311  NM_001273767.11  NP_001260696.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-123 guanine nucleotide-binding protein 49(a)
    (best of 2)
      X(9282179-9283774)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA26
    Nucleotide binding alpha subunit of the heterotrim...
    30(a)
    1 → many
    V(195168-196517) YER020W


    ENSEMBL Gene Tree for GNA13 (if available)
    TreeFam Gene Tree for GNA13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNA13 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNAT32  GNAT12  GNA122  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNA13 using alignment to 2 protein entries:     GNA13_HUMAN (see all proteins):
    GNA12    GNA11    GNA14    GNAQ    GNAI3    GNAT3
    GNAI1    GNAO1    GNAI2    GNAT2    GNA15    DKFZp686O0962
    GNAT1    GNAZ    GNAS    GNAL    GSA    WUGSC

    Find genes that share paralogs with GNA13           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GNA13
    PGOHUM00000263080


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNA13 (see all 869)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821070561,2
    --58397924(+) CTACGA/GGAACT 1 -- ds50010--------
    rs1463847061,2
    C--58397929(+) GGAAC-/TATTATAA 1 -- ds50010--------
    rs1870667501,2
    --58397945(+) GTGTGC/GAGTAT 1 -- ds50010--------
    rs110795461,2
    C,F,A,H--58398071(+) CAGACC/GTAACA 1 -- ds500116Minor allele frequency- G:0.26NS EA NA WA CSA 694
    rs1910072911,2
    --58398115(+) AGCTCA/GGGTAC 1 -- ds50010--------
    rs1443822151,2
    C--58398438(+) TAAATA/GTCAGT 1 -- ut310--------
    rs561664451,2
    C--58398472(+) TAGCAA/GGAGGC 1 -- ut310--------
    rs1152954311,2
    F--58398475(+) CAAGAG/AGCAAA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1177448091,2
    C,F--58398592(+) ATTGCC/TCATCC 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1511904021,2
    C--58398678(+) ATATAC/TGTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GNA13 (63005407 - 63052957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNA13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2123CNV Insertion18451855
    nsv112105CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNA13
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604406    OMIM disorders: --


    Find genes that share disorders with GNA13           About GenesLikeMe

    Genetic Association Database (GAD): GNA13
    Human Genome Epidemiology (HuGE) Navigator: GNA13 (3 documents)

    Export disorders for GNA13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNA13 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with GNA13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of GTP-binding protein alpha subunits in human thymocytes. (PubMed id 7791744)1, 2, 3 Kabouridis P.S.... Tsoukas C.D. (Mol. Cell. Biochem. 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. (PubMed id 12399457)1, 2 Manganello J.M....Le Breton G.C. (J. Biol. Chem. 2003)
    7. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)1, 2 Bhattacharyya R. and Wedegaertner P.B. (J. Biol. Chem. 2000)
    8. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. (PubMed id 15735747)1, 9 Grabocka E. and Wedegaertner P.B. (Oncogene 2005)
    9. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PubMed id 12515866)1, 9 Suzuki N....Kozasa T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    10. Galpha12 and galpha13 are phosphorylated during platelet activation. (PubMed id 8824244)1, 9 Offermanns S....Simon M.I. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10672 HGNC: 4381 AceView: GNA13 Ensembl:ENSG00000120063 euGenes: HUgn10672
    ECgene: GNA13 Kegg: 10672 H-InvDB: GNA13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNA13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNA13 gene:
    Search GeneIP for patents involving GNA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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