Aliases for GNA13 Gene
External Ids for GNA13 Gene
Previous GeneCards Identifiers for GNA13 Gene
GeneCards Summary for GNA13 Gene
GNA13 (Guanine Nucleotide Binding Protein (G Protein), Alpha 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNA13 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including cytoskeletal rearrangement and oncogenic transformation.