 |
 | Services
| |
 |
Aliases & Descriptions for GNA13
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| G13 1, 2 | | MGC46138 1, 2 |
| | | Descriptions |
|---|
| G alpha-13 3 | | G-protein subunit alpha-13 3 | | guanine nucleotide binding protein (G protein), alpha 13 2 |
|
| | Search outside databases for aliases for GNA13 genePrevious GC identifers: GC17P065359 GC17P068426 GC17M063424 GC17M063556 GC17M063555 |
Summaries for GNA13(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systemsGene Wiki entry for GNA13 |
Genomic Location for GNA13
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GNA13 gene 
Entrez Gene cytogenetic band: 17q24.3 Ensembl cytogenetic band: 17q24.1 HGNC cytogenetic band: 17q24GNA13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M060437:
(about GC identifiers)
Start:
|
60,437,295 bp from pter |
End:
|
60,483,216 bp from pter |
Size:
|
45,922 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010783.14
| Proteins for GNA13
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein subunit alpha-13 Size: 377 amino acids; 44050 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5
Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: Q8TD70Post-translational modifications:
Palmitoylation is critical for proper membrane localization and signaling1
Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006563.2
ENSEMBL proteins: ENSP00000239138
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GNA13: Assays for GNA13: | Protein
Domains/ Families for GNA13(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14344
ProtoNet protein and cluster: Q14344 2 Blocks protein families: IPB000469 G-protein alpha subunit group 12 signature IPB001019 Alpha G-protein (transducin) signature
UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344Similarity: Belongs to the G-alpha family. G(12) subfamily | Gene Function for GNA13
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006572
Applied Biosystems Silencer® siRNAs for GNA13
Sigma-Aldrich siRNA for GNA13  Sigma-Aldrich shRNA for GNA13  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006572                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006572                                  untagged cDNA clone in CMV expression vector: NM_006572 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006572
UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems10 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Gna13):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for GNA13
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/16 Sigma-Aldrich "Your Favorite Gene" Pathways for GNA13 (Your Favorite Gene powered by Ingenuity) (see all 16
) 
Gene Network CentralTM Interacting Genes and Proteins Network for GNA13 
5/44 Interacting proteins for GNA13 (Q143441 ENSP000002391383) via UniProtKB, MINT, and/or STRING (see all 44
)About this table
5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
): About this table
|
Drugs & Compounds for GNA13(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for GNA13 available from Tocris Bioscience 1 Novoseek chemical compound relationship for GNA13 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thromboxane a2 |
42.97 |
2 |
10318854 (1) |
About this table
|
Transcripts for GNA13(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006572
Sigma-Aldrich siRNA for GNA13  Sigma-Aldrich shRNA for GNA13  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006572 REFSEQ mRNAs for GNA13 gene: NM_006572.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006572               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006572                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006572                                  untagged cDNA clone in CMV expression vector: NM_006572  Additional cDNA sequence: AB075500.1 AF493902.1 AK002117.1 AK026902.1 AK301699.1 AK302400.1 AK313672.1 BC036756.1 BX647930.1 CR611712.1 L22075.1 7 DOTS entries: DT.452138 DT.92434397 DT.100792846 DT.101971191 DT.95272504 DT.100663740 DT.92434399 24/244 AceView cDNA sequences (see all 244
):BQ720684 BM825954 BM828172 CD366224 AA418765 BX479255 F13297 D63014 AA418721 BI772233 BM790882 BM464248 CR611712 AK002117 AW130618 BP872872 BI830443 AL039816 F09625 F11093 BQ929548 BU183024 AK026902 AA298148
highest scoring ESTs for GNA13:L22075 AF493902 AI992368 AL703871 BC036756 BG387532 BM549475 AA120897 AA122145 AA298148 Unigene Cluster for GNA13: Guanine nucleotide binding protein (G protein), alpha 13 Hs.515018 [show with all ESTs]Unigene Representative Sequence: NM_006572
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000239138
|
Expression for GNA13
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GNA13 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GNA13
1 / 2 / 3 11 probe-sets matching GNA13 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCTGTAAAGC
SOURCE GeneReport for Unigene cluster: Hs.515018
Expression variation in blood from EXPOLDB for GNA13 |
Orthologs for GNA13
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GNA13 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for GNA13
ENSEMBL Gene Tree for GNA13 | Paralogs for GNA13(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GNA13 gene
- GNA122
|
SNPs/Variants for GNA13(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GNA13 (up to first 250kb)
|
Disorders & Mutations for GNA13
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604406
|
Medical News for GNA13(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GNA13 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/71 PubMed articles for GNA13 gene (see all 71
):- Expression of GTP-binding protein alpha subunits in human thymocytes. (PubMed id 7791744)2, 3, 4 Kabouridis P.S.... Tsoukas C.D. (1995)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)3, 4 Chi A....Hunt D.F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. (PubMed id 12399457)3, 4 Manganello J.M....Le Breton G.C. (2003)
- Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)3, 4 Bhattacharyya R. and Wedegaertner P.B. (2000)
- Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. (PubMed id 15735747)1, 3 Grabocka E. and Wedegaertner P.B. (2005)
- Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PubMed id 12515866)1, 3 Suzuki N....Kozasa T. (2003)
- Galpha12 and galpha13 are phosphorylated during platelet activation. (PubMed id 8824244)1, 3 Offermanns S....Simon M.I. (1996)
- Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. (PubMed id 19074425)3 Suzuki N....Kozasa T. (2009)
- Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity. (PubMed id 18922893)3 Bartolome R.A....Teixido J. (2008)
|
Search for GNA13
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GNA13
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GNA13
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNA13(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GNA13(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GNA13:

 | |
 | | | | |
|
 |  |  |
| | | | Tocris compounds for GNA13 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|