Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNA13 Gene

protein-coding   GIFtS: 61
GCID: GC17M063005

guanine nucleotide binding protein (G protein), alpha 13
 Explore 11 diseases affiliated with
GNA13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GNA13    

Aliases
for GNA13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 131 2
G131 2
G Alpha-132 3
G-Protein Subunit Alpha-132 3
MGC461381
Guanine Nucleotide-Binding Protein Subunit Alpha-132

External Ids:    HGNC: 43811   Entrez Gene: 106722   Ensembl: ENSG000001200637   OMIM: 6044065   UniProtKB: Q143443   

Export aliases for GNA13 gene to outside databases

Previous GC identifers: GC17P065359 GC17P068426 GC17M063424 GC17M063556 GC17M063555 GC17M060437 GC17M058399


Summaries
for GNA13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems

summary for GNA13:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved
in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including
cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA13


Genomic Views
for GNA13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNA13 gene promoter:
         Max1   C/EBPalpha   CREB   S8   IRF-2   Nkx6-1   deltaCREB   Msx-1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNA13 promoter sequence
   Search SABiosciences Chromatin IP Primers for GNA13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.3   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q24

GNA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M063005:  view genomic region     (about GC identifiers)

Start:
 63,005,407 bp from pter      End:
 63,052,957 bp from pter
Size:
 47,551 bases      Orientation:
 minus strand

Proteins
for GNA13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-13  
Size: 377 amino acids; 44050 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide
binding site. Interacts with UBXD5. Interacts with HAX1
Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome fractions
from stage I to stage IV
Secondary accessions: B2R977 Q8TD70

Explore the universe of human proteins at neXtProt for GNA13: NX_Q14344

Post-translational modifications:

  • Palmitoylation is critical for proper membrane localization and signaling1
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14344

    • GNA13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006563.2  
    ENSEMBL proteins: 
     ENSP00000400717   ENSP00000439647  
    Reactome Protein details: Q14344
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for GNA13 
    GenScript Custom Purified and Recombinant Proteins Services for GNA13
    Novus Biologicals GNA13 Protein
    Novus Biologicals GNA13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic to internal side of plasma membrane IBA--
    GO:0031526brush border membrane IBA--
    GO:0042470melanosome IEA--


    GNA13 for ontologies           About GeneDecksing



    GNA13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: GNA13
    OriGene Custom Antibody Services for GNA13 
    GenScript Custom Superior Antibodies Services for GNA13
    Novus Biologicals GNA13 Antibodies
    Abcam antibodies for GNA13 
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for GNA13

    Assay Products for GNA13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNA13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GNA13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GNA13 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR000469 Gprotein_alpha_12

    Graphical View of Domain Structure for InterPro Entry Q14344

    ProtoNet protein and cluster: Q14344

    2 Blocks protein families:
    IPB000469 G-protein alpha subunit group 12 signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Similarity: Belongs to the G-alpha family. G(12) subfamily


    Function
    for GNA13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems

    miRNA
    Products:            		miRTarBase miRNAs that target GNA13:
    hsa-mir-155 (MIRT001546)

    OriGene 3'-UTR Clone: GNA13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA13
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA13 (see all 92):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: GNA13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA13 (see all 7)
    OriGene shRNA RFP: GNA13
    OriGene siRNA: GNA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GNA13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GNA13 (NM_006572)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GNA13
    Search LifeMap BioReagents cell lines for GNA13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI12681510
    GO:0005525GTP binding IEA--
    GO:0031683G-protein beta/gamma-subunit complex binding IBA--


    GNA13 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GNA13: Gna13tm1Soff Gna13tm2.1Cgh Gna13tm2.2Soff
         13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Gna13):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     nervous system  no phenotypic analysis  normal 

    GNA13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GNA13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-Beta Gamma Signaling
    		G-Beta Gamma Signaling1.00
    		Relaxin Pathway0.32
    		GHRH Signaling0.46
    		Hedgehog Signaling in Mammals0.22
    		CRHR Pathway0.44
    2CCR3 Pathway in Eosinophils
    		CCR3 Pathway in Eosinophils1.00
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Huntington's Disease Pathway0.18
    		fMLP Pathway0.43
    3G-protein signaling TC21 regulation pathway
    		G-protein signaling TC21 regulation pathway1.00
    		G-protein signaling_M-RAS regulation pathway0.71
    		G-protein signaling_TC21 regulation pathway1.00
    		G-protein signaling M-RAS regulation pathway0.71
    4G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins
    		G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins1.00
    		G-protein signaling_G-Protein alpha-12 signaling pathway0.40
    		G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins1.00
    		G-protein signaling G-Protein alpha-12 signaling pathway0.40
    5Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for GNA13 (see all 8)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling M-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    G-protein signaling G-Protein alpha-12 signaling pathway
    Signal transduction PKA signaling

    5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA13 (see all 63)
        Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    JNK Pathway

    5/8 GeneGo (Thomson Reuters) Pathways for GNA13 (see all 8)
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Signal transduction PKA signaling
    Development G-Proteins mediated regulation MARK-ERK signaling
    Cell adhesion Integrin inside-out signaling

    5/11 BioSystems Pathways for GNA13 (see all 11) 
        G13 Signaling Pathway
    G Protein Signaling Pathways
    TSH signaling pathway
    Regulation of Actin Cytoskeleton
    S1P3 pathway

    5/9        Reactome Pathways for GNA13 (see all 9)
        GPCR downstream signaling
    Hemostasis
    G alpha (12/13) signalling events
    Signal amplification
    Signal Transduction

    1 PharmGKB Pathway for GNA13
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for GNA13):
        Vascular smooth muscle contraction
    Long-term depression
    Regulation of actin cytoskeleton


    GNA13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNA13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/140 Interacting proteins for GNA13 (Q143441, 2, 3 ENSP000004007174) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF1Q928881, 2, 3, ENSP000003372614EBI-465387,EBI-465400 MINT-7909440 I2D: score=4 STRING: ENSP00000337261
    AKAP3O759693, ENSP000002288504I2D: score=3 STRING: ENSP00000228850
    ARHGEF11O150853, ENSP000003571774I2D: score=3 STRING: ENSP00000357177
    CDH1P128303, ENSP000002617694I2D: score=3 STRING: ENSP00000261769
    CDH2P190223, ENSP000002691414I2D: score=3 STRING: ENSP00000269141
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001569patterning of blood vessels IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006184GTP catabolic process TAS7791744
    GO:0006928cellular component movement TAS8999798


    GNA13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GNA13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNA13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNA13 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Mastoparan XG protein activator peptide[72093-22-2]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]

    3 HMDB Compounds for GNA13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    1 Novoseek chemical compound relationship for GNA13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 42.6 2 10318854 (1)

    Search CenterWatch for drugs/clinical trials and news about GNA13 

    Transcripts
    for GNA13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GNA13 gene: 
    NM_006572.4  

    Unigene Cluster for GNA13:

    Guanine nucleotide binding protein (G protein), alpha 13
    Hs.515018  [show with all ESTs]
    Unigene Representative Sequence: NM_006572
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439174(uc010wqh.2 uc002jfc.3) ENST00000541118

    miRNA
    Products:             		 OriGene 3'-UTR Clone: GNA13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA13
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA13 (see all 92):
    hsa-miR-411* hsa-miR-548j hsa-miR-140-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-200a hsa-miR-128 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: GNA13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA13 (see all 7)
    OriGene shRNA RFP: GNA13
    OriGene siRNA: GNA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GNA13 (NM_006572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNA13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13

    Additional cDNA sequence: 

    AB075500.1 AF493902.1 AK002117.1 AK026902.1 AK301699.1 AK302400.1 AK313672.1 BC011925.1 
    BC036756.1 BX647930.1 L22075.1 

    7 DOTS entries:

    DT.452138  DT.92434397  DT.100792846  DT.101971191  DT.95272504  DT.100663740  DT.92434399 

    24/244 AceView cDNA sequences (see all 244):

    F13305 AF493902 AA418765 AU138594 BM825954 BQ929548 F11093 AW130618 
    F09625 AV682718 BQ720684 AK002117 BU183024 CR611712 CD366224 BP872872 
    BM828172 F13297 BM790882 AK026902 BX479255 BI830443 BC036756 BM464248 

    GeneLoc Exon Structure


    Expression
    for GNA13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNA13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGTAAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See GNA13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNA13

    SOURCE GeneReport for Unigene cluster: Hs.515018
        SABiosciences Custom PCR Arrays for GNA13
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GNA13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13

    Orthologs
    for GNA13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNA13 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GNA131 guanine nucleotide binding protein (G protein), alpha more 85.5(n)
    92.04(a)    		   417434  XM_415686.3  XP_415686.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GNA136
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343260.1(1398524-1428679)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF549941.12   -- 78.42(n)    AF549941.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CD052686.12   -- 76.22(n)    CD052686.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cta1 , 3 G-protein coupled receptor protein signaling
    pathway more3
    concertina1    		 55(a)3
    55.62(n)1
    57.43(a)1    		   2 40 (determined by in situ hybridization)3
    33551311  NM_001042956.11  NP_001036421.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea gpa-123 guanine nucleotide-binding protein 49(a)
    (best of 2)    		   X(9282179-9283774)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons XLG36
    XLG26
    (see all 4)    		 extra-large GTP-binding protein 2
    (see all 4)    		 9(a)
    8(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(11464985-11469185)
    4(16441179-16445005)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 G-protein alpha subunit, putative, expressed
    (see all 5)    		 9(a)
    9(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 12(24838937-24843804)
    6(633143-639480)


    ENSEMBL Gene Tree for GNA13 (if available)
    TreeFam Gene Tree for GNA13 (if available) 

    Paralogs
    for GNA13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNA13 gene
    GNAQ2  GNA142  GNA112  GNAI32  GNAT22  GNAT32  GNAT12  GNAI22  
    GNA152  GNA122  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNA13 using alignment to 2 protein entries:     GNA13_HUMAN (see all proteins):
    GNA12    GNA11    GNA14    GNAQ    GNAI3    GNAT3
    GNAI1    GNAO1    GNAI2    GNAT2    GNA15    DKFZp686O0962
    GNAT1    GNAZ    GNAS    GNAL    GSA    WUGSC

    GNA13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GNA13
    PGOHUM00000263080


    Genomic Variants
    for GNA13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/12 NCBI SNPs in GNA13 are shown (see all 12)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs99111881,2
    		C--63014254(+) AAAAAA/GAAAGA 1 -- int1 trp30--------
    rs99111891,2
    		C--63014256(+) AAAAAA/GAGAGA 1 -- int1 trp30--------
    rs760935921,2
    		--63034544(+) TTTATT/CTTTAG 1 -- int11Minor allele frequency- C:0.01EA 120
    rs58216331,2
    		C--63039410(-) AAAAA-/ATTAAT 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs1429355011,2
    		C,--63046536(+) ATCTC-/TATGTGT 1 -- int10--------
    rs106100731,2
    		C--63046537(+) TCTCT-/ATGTGTC 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs742512801,2
    		C--63046537(+) TCTCTA/C/GTGTGT 1 -- int10--------
    rs106748891,2
    		C,--63053892(+) CACTCAT/-GTGCA 1 -- us2k12Minor allele frequency- -:0.00NA CSA 4
    rs720212531,2
    		----63028011(+) AGAGA-/AAGAAAG 1 -- int10--------
    rs756711491,2
    		----63028936(+) AAAAAA/CCACAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for GNA13 (63005407 - 63052957 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GNA13
         1 CNV: 5873

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNA13
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA13

    Disorders / Diseases
    for GNA13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GNA13 for disorders           About GeneDecksing

    OMIM gene information: 604406    OMIM disorders: --

    11 diseases for GNA13:    About MalaCards
    fainting    azoospermia    astrocytoma    lung cancer
    prostate cancer    breast cancer    prostatitis    leukemia
    neuronitis    huntington's disease    retinitis

    Human Genome Epidemiology (HuGE) Navigator: GNA13 (3 documents)

    Export disorders for GNA13 gene to outside databases

    Publications
    for GNA13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNA13 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with GNA13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of GTP-binding protein alpha subunits in human thymocytes. (PubMed id 7791744)1, 2, 3 Kabouridis P.S.... Tsoukas C.D. (1995)
    2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. (PubMed id 12399457)1, 2 Manganello J.M....Le Breton G.C. (2003)
    6. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)1, 2 Bhattacharyya R. and Wedegaertner P.B. (2000)
    7. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. (PubMed id 15735747)1, 9 Grabocka E. and Wedegaertner P.B. (2005)
    8. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PubMed id 12515866)1, 9 Suzuki N....Kozasa T. (2003)
    9. Galpha12 and galpha13 are phosphorylated during platelet activation. (PubMed id 8824244)1, 9 Offermanns S....Simon M.I. (1996)
    10. Activation of p115-RhoGEF requires direct association of Ga13 and the Dbl homology domain. (PubMed id 22661716)1 Chen Z....Sternweis P.C. (2012)

    External Searches for GNA13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GNA13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10672 HGNC: 4381 AceView: GNA13 Ensembl:ENSG00000120063 euGenes: HUgn10672
    ECgene: GNA13 Kegg: 10672 H-InvDB: GNA13

    Other Databases showing GNA13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GNA13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNA13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GNA13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GNA13 gene:
    Search GeneIP for patents involving GNA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for GNA13 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for GNA13   OriGene shRNA RFP for GNA13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA13  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GNA13   OriGene 3'-UTR Clone for GNA13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GNA13   OriGene Custom Protein Services for GNA13  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNA13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNA13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA13
     GenScript Custom Purified and Recombinant Proteins Services for GNA13 GenScript cDNA clones with any tag delivered in your preferred vector for GNA13
     GenScript Custom Assay Services for GNA13 GenScript Custom Superior Antibodies Services for GNA13
     GenScript Custom overexpressing Cell Line Services for GNA13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GNA13 promoter
     Search Chromatin IP Primers for GNA13
     RT2 qPCR Primer Assay in human, mouse, rat GNA13
     GNC Network for GNA13
     SABiosciences PCR Arrays including human, mouse, rat GNA13
     Tocris compounds for GNA13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GNA13 antibodies
     GNA13 proteins
     GNA13 lysates
     Antibodies for GNA13
     See all of Abcam's Antibodies, Kits and Proteins for GNA13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for GNA13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA13
     SwitchGear 3'UTR luciferase reporter plasmids for GNA13
     SwitchGear Promoter luciferase reporter plasmids for GNA13
     Search ThermoFisher Antibodies for GNA13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA13
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      GNA13 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4