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Aliases for GNA13 Gene

Aliases for GNA13 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha 13 2 3
  • G-Protein Subunit Alpha-13 3 4
  • G Alpha-13 3 4
  • Guanine Nucleotide-Binding Protein Subunit Alpha-13 3
  • G13 3

External Ids for GNA13 Gene

Previous GeneCards Identifiers for GNA13 Gene

  • GC17P065359
  • GC17P068426
  • GC17M063424
  • GC17M063556
  • GC17M063555
  • GC17M060437
  • GC17M063005
  • GC17M058399

Summaries for GNA13 Gene

GeneCards Summary for GNA13 Gene

GNA13 (Guanine Nucleotide Binding Protein (G Protein), Alpha 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNA13 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Tocris Summary for GNA13 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA13 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNA13 Gene

Genomics for GNA13 Gene

Regulatory Elements for GNA13 Gene

Genomic Location for GNA13 Gene

65,009,289 bp from pter
65,056,839 bp from pter
47,551 bases
Minus strand

Genomic View for GNA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNA13 Gene

Proteins for GNA13 Gene

  • Protein details for GNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-13
    Protein Accession:
    Secondary Accessions:
    • B2R977
    • B7Z7R0
    • F5H1G8
    • Q8TD70

    Protein attributes for GNA13 Gene

    377 amino acids
    Molecular mass:
    44050 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22.

    Alternative splice isoforms for GNA13 Gene


neXtProt entry for GNA13 Gene

Proteomics data for GNA13 Gene at MOPED

Post-translational modifications for GNA13 Gene

  • Palmitoylation is critical for proper membrane localization and signaling.
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.
  • Ubiquitination at Lys214 and Lys372
  • Modification sites at PhosphoSitePlus

Other Protein References for GNA13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNA13 Gene

Domains for GNA13 Gene

Suggested Antigen Peptide Sequences for GNA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14344
  • Belongs to the G-alpha family. G(12) subfamily.
genes like me logo Genes that share domains with GNA13: view

No data available for Gene Families for GNA13 Gene

Function for GNA13 Gene

Molecular function for GNA13 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Gene Ontology (GO) - Molecular Function for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI 10026210
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNA13: view
genes like me logo Genes that share phenotypes with GNA13: view

Animal Models for GNA13 Gene

MGI Knock Outs for GNA13:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNA13 Gene

Localization for GNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNA13 Gene

Membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei.

Subcellular locations from

Jensen Localization Image for GNA13 Gene COMPARTMENTS Subcellular localization image for GNA13 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with GNA13: view

Pathways for GNA13 Gene

genes like me logo Genes that share pathways with GNA13: view

Gene Ontology (GO) - Biological Process for GNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis --
GO:0001569 patterning of blood vessels IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006928 movement of cell or subcellular component TAS 8999798
genes like me logo Genes that share ontologies with GNA13: view

Compounds for GNA13 Gene

(5) Tocris Compounds for GNA13 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNA13 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP

(1) Novoseek inferred chemical compound relationships for GNA13 Gene

Compound -log(P) Hits PubMed IDs
thromboxane a2 42.6 1
genes like me logo Genes that share compounds with GNA13: view

Transcripts for GNA13 Gene

mRNA/cDNA for GNA13 Gene

Unigene Clusters for GNA13 Gene

Guanine nucleotide binding protein (G protein), alpha 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNA13 Gene

No ASD Table

Relevant External Links for GNA13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNA13 Gene

mRNA expression in normal human tissues for GNA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNA13 Gene

This gene is overexpressed in Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNA13 Gene

SOURCE GeneReport for Unigene cluster for GNA13 Gene Hs.515018

mRNA Expression by UniProt/SwissProt for GNA13 Gene

Tissue specificity: Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).
genes like me logo Genes that share expressions with GNA13: view

Orthologs for GNA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNA13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNA13 35
  • 99.56 (n)
  • 99.2 (a)
GNA13 36
  • 99 (a)
(Bos Taurus)
Mammalia GNA13 35
  • 86.64 (n)
  • 96.1 (a)
GNA13 36
  • 96 (a)
(Canis familiaris)
Mammalia GNA13 35
  • 92.79 (n)
  • 97.52 (a)
GNA13 36
  • 97 (a)
(Mus musculus)
Mammalia Gna13 35
  • 90.72 (n)
  • 96.82 (a)
Gna13 16
Gna13 36
  • 97 (a)
(Monodelphis domestica)
Mammalia GNA13 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GNA13 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Gna13 35
  • 91.25 (n)
  • 97.08 (a)
(Gallus gallus)
Aves GNA13 35
  • 85.5 (n)
  • 92.04 (a)
GNA13 36
  • 92 (a)
(Anolis carolinensis)
Reptilia GNA13 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145489 35
  • 77.45 (n)
  • 90.45 (a)
(Danio rerio)
Actinopterygii gna13a 35
  • 74.65 (n)
  • 85.64 (a)
gna13a 36
  • 85 (a)
gna13b 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009457 35
  • 58.41 (n)
  • 56.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40005 36
  • 55 (a)
cta 35
  • 55.62 (n)
  • 57.43 (a)
cta 36
  • 45 (a)
cta 37
  • 55 (a)
(Caenorhabditis elegans)
Secernentea gpa-12 36
  • 49 (a)
gpa-12 37
  • 49 (a)
gpa-14 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPA2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for GNA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNA13 Gene

Gene Tree for GNA13 (if available)
Gene Tree for GNA13 (if available)

Paralogs for GNA13 Gene

Paralogs for GNA13 Gene

Selected SIMAP similar genes for GNA13 Gene using alignment to 2 proteins: Pseudogenes for GNA13 Gene

genes like me logo Genes that share paralogs with GNA13: view

Variants for GNA13 Gene

Sequence variations from dbSNP and Humsavar for GNA13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs982586 -- 65,057,385(+) ATCCT(C/T)CCGCC upstream-variant-2KB
rs1036889 -- 65,045,470(-) agtgc(A/C)tgatc intron-variant
rs1036891 -- 65,043,744(-) TTGAT(G/T)TTTGT intron-variant
rs1062597 - 65,014,730(-) AAATG(C/G)TTGAT missense, reference
rs1234877 -- 65,037,456(-) AGGAA(A/G)AATCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNA13 Gene

Variant ID Type Subtype PubMed ID
nsv112105 CNV Loss 16902084
nsv2123 CNV Insertion 18451855

Relevant External Links for GNA13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNA13 Gene

Disorders for GNA13 Gene

Relevant External Links for GNA13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GNA13: view

No data available for UniProtKB/Swiss-Prot for GNA13 Gene

Publications for GNA13 Gene

  1. Expression of GTP-binding protein alpha subunits in human thymocytes. (PMID: 7791744) Kabouridis P.S. … Tsoukas C.D. (Mol. Cell. Biochem. 1995) 2 3 4
  2. Galpha12 and galpha13 are phosphorylated during platelet activation. (PMID: 8824244) Offermanns S. … Simon M.I. (J. Biol. Chem. 1996) 3 23
  3. Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. (PMID: 12515866) Suzuki N. … Kozasa T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23
  4. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PMID: 10747909) Bhattacharyya R. … Wedegaertner P.B. (J. Biol. Chem. 2000) 3 4
  5. PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. (PMID: 12399457) Manganello J.M. … Le Breton G.C. (J. Biol. Chem. 2003) 3 4

Products for GNA13 Gene

Sources for GNA13 Gene

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