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GNA13 Gene

protein-coding   GIFtS: 60

GC17M060437
guanine nucleotide binding protein (G protein), alpha 13
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
G13 1, 2
MGC46138 1, 2
Descriptions
G alpha-13 3
G-protein subunit alpha-13 3
guanine nucleotide binding protein (G protein), alpha 13 2
External Ids
HGNC: 43811
Entrez Gene: 106722
UniProtKB: Q143443
Ensembl: ENSG000001200637
Search outside databases for aliases for GNA13 gene

Previous GC identifers: GC17P065359 GC17P068426 GC17M063424 GC17M063556 GC17M063555

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or
transducers in various transmembrane signaling systems

Gene Wiki entry for GNA13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GNA13 gene  

Entrez Gene cytogenetic band: 17q24.3   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q24

GNA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M060437:     (about GC identifiers)

Start:
60,437,295 bp from pter
End:
60,483,216 bp from pter
Size:
45,922 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-13  
Size: 377 amino acids; 44050 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the
guanine nucleotide binding site. Interacts with UBXD5
Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in
melanosome fractions from stage I to stage IV
Secondary accessions: Q8TD70

Post-translational modifications:

  • Palmitoylation is critical for proper membrane localization and signaling1
  • Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and
    inhibits Rho activation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006563.2  

    ENSEMBL proteins: 
    ENSP00000239138 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (G protein alpha 13)
    Human Recombinant Proteins from Abnova (GNA13)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0042470 melanosome IEA--
    About this table

    Antibodies for GNA13: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GNA13
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (G protein alpha 13), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (GNA13)
    Novus Biologicals Antibodies for GNA13

    Assays for GNA13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000469 Gprotein_alpha12
     IPR001019 Gprotein_alph_bd


       GeneDecks  GNA13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14344

    ProtoNet protein and cluster: Q14344

    2 Blocks protein families:
    IPB000469 G-protein alpha subunit group 12 signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Similarity: Belongs to the G-alpha family. G(12) subfamily

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GNA13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GNA13)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006572

                  Applied Biosystems Silencer® siRNAs for GNA13

                  Sigma-Aldrich siRNA for GNA13  
                         Sigma-Aldrich shRNA for GNA13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006572
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006572
                                     untagged cDNA clone in CMV expression vector: NM_006572 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006572

    UniProtKB/Swiss-Prot: GNA13_HUMAN, Q14344
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or
    transducers in various transmembrane signaling systems

    10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gna13):

    embryogenesisgrowth/sizehematopoietic systemhomeostasis/metabolism
    immune systemlethality-prenatal/perinatalno phenotypic analysisnormalskin/coat/nails

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS7791744
    GO:0004871 signal transducer activity IEA--
    GO:0005515 protein binding IPI10026210
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5 Invitrogen iPath™ Online BioAtlas - Pathways for GNA13 (Maps provided by GeneGo):
     G-Proteins mediated regulation MARK-ERK signaling
     PIP3 signaling in cardiac myocytes
     G-Protein alpha-12 signaling pathway
     RhoA regulation pathway
     PIP3 signaling in B lymphocytes

       GeneDecks  GNA13 for the pathways selected above  
    About GeneDecksing

    5/8 Millipore Pathways for GNA13 (see all 8 )
     G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
     G-protein signaling M-RAS regulation pathway
     G-protein signaling TC21 regulation pathway
     G-protein signaling G-Protein alpha-12 signaling pathway
     Signal transduction PKA signaling

       GeneDecks  GNA13 for the pathways selected above  
    About GeneDecksing

    5/16 Sigma-Aldrich "Your Favorite Gene" Pathways for  GNA13  (Your Favorite Gene powered by Ingenuity) (see all 16
     Androgen Signaling
     CREB Signaling in Neurons
     Axonal Guidance Signaling
     Actin Cytoskeleton Signaling
     Molecular Mechanisms of Cancer

       GeneDecks  GNA13 for the pathways selected above  
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    3 Kegg Pathways  (Kegg details for GNA13):
     hsa04270 Vascular smooth muscle contraction
     hsa04730 Long-term depression
     hsa04810 Regulation of actin cytoskeleton

       GeneDecks  GNA13 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  GNA13 


    5/44 Interacting proteins for GNA13 (Q143441 ENSP000002391383) via UniProtKB, MINT, and/or STRING (see all 44 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF1Q928881, ENSP000003673943EBI-465387, EBI-465400 STRING (score=.995)
    ARHGEF12ENSP000003490563STRING (score=.995)
    TBXA2RENSP000002484193STRING (score=.986)
    F2RENSP000003213263STRING (score=.972)
    GNA12ENSP000002753643STRING (score=.961)
    About this table

    5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569 patterning of blood vessels IEA--
    GO:0001701 in utero embryonic development IEA--
    GO:0006928 cell motion TAS8999798
    GO:0007165 signal transduction TAS7791744
    GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for GNA13 available from Tocris Bioscience
    1 Novoseek chemical compound relationship for GNA13 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 42.97 2 10318854 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GNA13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GNA13)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006572

                  Sigma-Aldrich siRNA for GNA13  
                         Sigma-Aldrich shRNA for GNA13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006572  

    REFSEQ mRNAs for GNA13 gene: 

    NM_006572.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006572  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006572
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006572
                                     untagged cDNA clone in CMV expression vector: NM_006572 

    Additional cDNA sequence: 

    AB075500.1 AF493902.1 AK002117.1 AK026902.1 AK301699.1 AK302400.1 AK313672.1 BC036756.1 
    BX647930.1 CR611712.1 L22075.1 

    7 DOTS entries:

    DT.452138  DT.92434397  DT.100792846  DT.101971191  DT.95272504  DT.100663740  DT.92434399 

    24/244 AceView cDNA sequences (see all 244 ):

    BQ720684 BM825954 BM828172 CD366224 AA418765 BX479255 F13297 D63014 
    AA418721 BI772233 BM790882 BM464248 CR611712 AK002117 AW130618 BP872872 
    BI830443 AL039816 F09625 F11093 BQ929548 BU183024 AK026902 AA298148 

    highest scoring ESTs for GNA13:

    L22075 AF493902 AI992368 AL703871 BC036756 BG387532 BM549475 AA120897 AA122145 AA298148 

    Unigene Cluster for GNA13:

    Guanine nucleotide binding protein (G protein), alpha 13
    Hs.515018  [show with all ESTs]
    Unigene Representative Sequence: NM_006572


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000239138  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GNA13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GNA13

    1 / 2 / 3

    11 probe-sets matching GNA13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    33635_at2, 3 U95-A 1 1.00 1.00 0.65 0.66 L22075 1.00 1.00 1.00 1

    1139_at2, 3 U95-A 1 1.00 1.00 0.85 0.54 L22075 1.00 1.00 1.00 1
    47128_at2, 3 U95-B 1 1.00 1.00 0.97 1.18 AI341820 0.40 1.00 0.76 1

    58827_at2, 3 U95-C 1 1.00 1.00 0.93 1.79 AI992368 0.80 1.00 0.91 1

    48764_at2, 3 U95-C 1 0.81 1.00 0.88 0.86 AI928136 0.60 1.00 0.82 1

    224761_at2, 3 U133-B 1 1.00 1.00 -- -- AI928136 0.60 1.00 0.82 1

    227539_at2, 3 U133-B 1 1.00 1.00 -- -- AW298099 0.20 1.00 0.72 1

    206917_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006572 0.60 1.00 0.82 1

    224761_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227539_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206917_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  GNA13 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCTGTAAAGC

    SOURCE GeneReport for Unigene cluster: Hs.515018

    Expression variation in blood from EXPOLDB for GNA13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for GNA13 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GNA131   -- guanine nucleotide binding protein (G protein), alpha more 92.79(n)
    97.52(a)
    490901  XM_548023.2  XP_548023.2 
    chimpanzee
    (Pan troglodytes)
    GNA131   -- guanine nucleotide binding protein (G protein), alpha more 99.56(n)
    99.2(a)
    454827  XM_511632.2  XP_511632.2 
    rat
    (Rattus norvegicus)
    Gna131   -- guanine nucleotide binding protein, alpha 13 91.25(n)
    97.08(a)
    303634  NM_001013119.1  NP_001013137.1 
    mouse
    (Mus musculus)
    Gna131, 5 11 (68.00 cM)5
    guanine nucleotide binding protein, alpha 131, 5 90.72(n)1
    96.82(a)1
    146741  NM_010303.31  NP_034433.31 
     AI4264675  AK0118515  (see all 23)
    chicken
    (Gallus gallus)
    GNA131   -- guanine nucleotide binding protein (G protein), alpha more 85.5(n)
    92.04(a)
    417434  XM_415686.2  XP_415686.1 
    About this table        Species with no ortholog for GNA13

    ENSEMBL Gene Tree for GNA13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GNA13 gene
    GNA122  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/195 NCBI SNPs in GNA13 are shown (see all 195 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 73)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs118704311,2
    A,C,F60437557(+) ACAGTA/GTAACA 1 -- ut31 ese33Minor allele frequency- G:0.05NA 142
    rs73428141,2
    C,H60439111(+) GCTCAT/CGGATT 1 -- ut31 ese34Minor allele frequency- C:0.00EU EA WA 418
    rs80768261,2
    F,H60438384(+) AGCACC/TTTTTC 1 -- ut31 ese34Minor allele frequency- T:0.01EU EA WA 414
    rs80649621,2
    H60484820(+) GGGAGC/TGGAGG 1 -- ng31 tfbs34Minor allele frequency- T:0.00EU EA WA 416
    rs10625971,2
    H60441310(-) AAATGG/CTTGAT 1 L/V mis1 ese35Minor allele frequency- C:0.00MN EU EA WA 590
    --
    rs9825861,2
    C60483965(+) atcctC/Tccgcc 1 -- ng310--------
    rs22303121,2
    F,H60441332(-) GAAATA/CAAAAA 1 I/I syn15Minor allele frequency- C:0.01MN EU EA WA 476
    rs116566021,2
    H60480109(+) TCATAG/AGCATT 1 A/A syn1 ese34Minor allele frequency- A:0.00EU EA WA 420
    rs22712821,2
    H60483024(-) GTGAAG/AATCCT 1 K/K syn1 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs14431641,2
    A,C,F,H,O60479914(+) tcattG/Agagac 1 -- int17Minor allele frequency- A:0.18EU EA WA NA 560
    About this table

    HapMap Linkage Disequilibrium images for GNA13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604406

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/71 PubMed articles for GNA13 gene (see all 71 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10672 HGNC: 4381 AceView: GNA13 Ensembl:ENSG00000120063 euGenes: HUgn10672
    ECgene: GNA13 H-InvDB: GNA13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GNA13:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GNA13-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GNA13 Antibodies for GNA13
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GNA13 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for GNA13

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