Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNA12 Gene

protein-coding GIFtS: 65
GCID: GC07M002767

guanine nucleotide binding protein (G protein) alpha 12

Explore 14 diseases affiliated with
GNA12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein) Alpha 12¹ ²		NNX3²
Gep¹		RMP²
G Alpha-12² ³		WUGSC:H_GS165O14.2²
G-Protein Subunit Alpha-12² ³		Guanine Nucleotide-Binding Protein Subunit Alpha-12²

External Ids:	HGNC: 4380¹	Entrez Gene: 2768²	Ensembl: ENSG00000146535⁷	OMIM: 604394⁵	UniProtKB: Q03113³

Export aliases for GNA12 gene to outside databases

Previous GC identifers: GC07M002415 GC07M002515 GC07M002512 GC07M002540 GC07M002734 GC07M002686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems

summary for GNA12:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved

in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including

cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNA12 gene promoter:
HFH-3 Bach2 CUTL1 HNF-1A FOXI1 AREB6 HNF-1 Zic1 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): GNA12 promoter sequence

Search SABiosciences Chromatin IP Primers for GNA12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.2 Ensembl cytogenetic band: 7p22.2 HGNC cytogenetic band: 7p22.3

GNA12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA12 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M002767: view genomic region (about GC identifiers)

Start:	2,767,739 bp from pter	End:	2,883,959 bp from pter
Size:	116,221 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 2,815,641-2,931,835

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein subunit alpha-12

Size: 381 amino acids; 44279 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide

binding site. Interacts with UBXD5

Subcellular location: Membrane; Lipid-anchor

Secondary accessions: A4D204 Q2T9L1 Q86UM8 Q8TD71 Q9UDU9

Explore the universe of human proteins at neXtProt for GNA12: NX_Q03113

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q03113

GNA12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_031379.2

ENSEMBL proteins:

ENSP00000275364 ENSP00000385935 ENSP00000386054 ENSP00000391462 ENSP00000437469

ENSP00000380160

Reactome Protein details: Q03113
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GNA12 OriGene Custom Protein Services for GNA12
	GenScript Custom Purified and Recombinant Proteins Services for GNA12
	Novus Biologicals GNA12 Protein Novus Biologicals GNA12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005834	heterotrimeric G-protein complex	IBA	--
GO:0005886	plasma membrane	TAS	--
GO:0031234	extrinsic to internal side of plasma membrane	IBA	--
GO:0031526	brush border membrane	IBA	--

GNA12 for ontologies About GeneDecksing

GNA12 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for GNA12
	GenScript Custom Superior Antibodies Services for GNA12
	Novus Biologicals GNA12 Antibodies
	Abcam antibodies for GNA12
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GNA12

Assay Products for GNA12:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GNA12
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNA12 for domains About GeneDecksing

3 InterPro domains/families:

IPR001019 Gprotein_alpha_su

IPR011025 GproteinA_insert

IPR000469 Gprotein_alpha_12

Graphical View of Domain Structure for InterPro Entry Q03113

ProtoNet protein and cluster: Q03113

2 Blocks protein families:

IPB000469 G-protein alpha subunit group 12 signature

IPB001019 Alpha G-protein (transducin) signature

UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113

Similarity: Belongs to the G-alpha family. G(12) subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various

transmembrane signaling systems

miRNA Products:		OriGene 3'-UTR Clone: GNA12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA12
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA12 (see all 39):
		hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-507 hsa-miR-424 hsa-miR-1244 hsa-miR-15b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA12 (see all 6) OriGene siRNA: GNA12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNA12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNA12 (NM_007353)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNA12
		Search LifeMap BioReagents cell lines for GNA12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA12

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IBA	--
GO:0004871	signal transducer activity	IBA	--
GO:0005515	protein binding	IPI	10026210
GO:0005525	GTP binding	IEA	--
GO:0019001	guanyl nucleotide binding	--	--

GNA12 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for GNA12:

Bright nuclei

Decreased Salmonella enterica

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-out Gna12^tm1Citb for GNA12
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gna12):

cardiovascular system	cellular	embryogenesis	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	muscle	normal

GNA12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-Beta Gamma Signaling

G-Beta Gamma Signaling	1.00	Relaxin Pathway	0.32
GHRH Signaling	0.46	Hedgehog Signaling in Mammals	0.22
CRHR Pathway	0.44

CCR3 Pathway in Eosinophils

CCR3 Pathway in Eosinophils	1.00	CXCR4 Pathway	0.39
VEGF and S-1P Signaling	0.44	Huntington's Disease Pathway	0.18
fMLP Pathway	0.43

G-protein signaling TC21 regulation pathway

	G-protein signaling TC21 regulation pathway	1.00			G-protein signaling_M-RAS regulation pathway	0.71
	G-protein signaling_TC21 regulation pathway	1.00			G-protein signaling M-RAS regulation pathway	0.71

G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins

	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins	1.00			G-protein signaling_G-Protein alpha-12 signaling pathway	0.40
	G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins	1.00			G-protein signaling G-Protein alpha-12 signaling pathway	0.40

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for GNA12 (see all 8)

	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling M-RAS regulation pathway
	G-protein signaling TC21 regulation pathway
	G-protein signaling G-Protein alpha-12 signaling pathway
	Signal transduction PKA signaling

5/66 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA12 (see all 66)

	RhoA Pathway
	Molecular Mechanisms of Cancer
	Visual Cycle in Retinal Rods
	CDK5 Pathway
	JNK Pathway

5/8 GeneGo (Thomson Reuters) Pathways for GNA12 (see all 8)

	G-protein signaling TC21 regulation pathway
	G-protein signaling M-RAS regulation pathway
	Signal transduction PKA signaling
	Development G-Proteins mediated regulation MARK-ERK signaling
	Cell adhesion Integrin inside-out signaling

5/11 BioSystems Pathways for GNA12 (see all 11)

	G Protein Signaling Pathways
	MAPK signaling pathway
	TSH signaling pathway
	Regulation of Actin Cytoskeleton
	S1P2 pathway

5/7 Reactome Pathways for GNA12 (see all 7)

	GPCR downstream signaling
	Hemostasis
	G alpha (12/13) signalling events
	Signal Transduction
	Signaling by GPCR

1 PharmGKB Pathway for GNA12

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for GNA12):

	MAPK signaling pathway
	Vascular smooth muscle contraction
	Long-term depression
	Regulation of actin cytoskeleton

GNA12 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GNA12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/102 Interacting proteins for GNA12 (Q03113^{2, 3} ENSP00000275364⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 102)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2R1A	P30153²^,³, ENSP00000324804⁴	MINT-8239002 I2D: score=3 STRING: ENSP00000324804
ARHGEF1	Q92888²^,³, ENSP00000337261⁴	MINT-7909421 I2D: score=1 STRING: ENSP00000337261
ARHGEF11	O15085³, ENSP00000357177⁴	I2D: score=3 STRING: ENSP00000357177
CDH15	P55291³, ENSP00000289746⁴	I2D: score=3 STRING: ENSP00000289746
CDH2	P19022³, ENSP00000269141⁴	I2D: score=3 STRING: ENSP00000269141

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0006184	GTP catabolic process	TAS	8290554
GO:0007165	signal transduction	--	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8290554
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA	--

GNA12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GNA12 available from Tocris Bioscience About this table

Compound	Action	CAS #
Mastoparan X	G protein activator peptide	[72093-22-2]
G-Protein antagonist peptide	Inhibits G protein activation by GPCRs	[143675-79-0]

3 HMDB Compounds for GNA12 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about GNA12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNA12 gene:

NM_007353.2

Unigene Cluster for GNA12:

Guanine nucleotide binding protein (G protein) alpha 12

Hs.487341 [show with all ESTs]

Unigene Representative Sequence: NM_007353

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000275364(uc003smu.3 uc011jwb.2) ENST00000491117 ENST00000407904(uc003smt.3)

ENST00000407653 ENST00000496740 ENST00000471281 ENST00000485329 ENST00000447791

ENST00000544127 ENST00000396960

miRNA Products:		OriGene 3'-UTR Clone: GNA12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNA12
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA12 (see all 39):
		hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-507 hsa-miR-424 hsa-miR-1244 hsa-miR-15b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA12 (see all 6) OriGene siRNA: GNA12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GNA12 (NM_007353)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNA12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA12

Additional cDNA sequence:

AF493901.1 AK024696.1 AK024834.1 AK025582.1 AK025894.1 AK122830.1 AK127842.1 AK128701.1

AK295830.1 AL512719.1 BC007400.2 BC009457.1 BC063396.1 BC087537.1 BC111464.1 L01694.1

XR_158813.2 XR_159074.2 XR_159474.2 XR_171621.1

18 DOTS entries:

DT.101983287 DT.444259 DT.100821049 DT.101983288 DT.429058 DT.95365859 DT.40127457 DT.121071657

DT.121071708 DT.95365860 DT.100821048 DT.100821052 DT.121071652 DT.121071688 DT.91755629 DT.95320949

DT.95361660 DT.100713633

24/303 AceView cDNA sequences (see all 303):

BQ938945 AI027568 BQ674000 BX279714 CA309867 BU540548 T33620 AA897175

BM786349 AL702015 BF510440 BM664421 AA485595 BM819097 CA389909 AL713369

BM549157 CD300413 AW085139 Z39001 CA390161 BQ222491 CD675462 CR622889

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GNA12 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10a	·	10b	·	10c	·	10d	·	10e
SP1:													-		-		-		-		-		-		-
SP2:			-		-		-						-		-		-		-		-		-		-
SP3:																					-				-
SP4:					-		-								-		-		-		-		-		-
SP5:																					-		-		-

ECgene alternative splicing isoforms for GNA12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNA12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGGGGTGA

About this image
See GNA12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNA12

SOURCE GeneReport for Unigene cluster: Hs.487341

SABiosciences Custom PCR Arrays for GNA12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GNA12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNA12 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GNA12¹	guanine nucleotide binding protein (G protein) alpha more	80.84(n) 92.91(a)		769924 XM_001233236.2 XP_001233237.2
lizard (Anolis carolinensis)	Reptilia	GNA12⁶	--	91(a)	1 ↔ 1	GL343340.1(399517-410617)
zebrafish (Danio rerio)	Actinopterygii	gna12a¹	guanine nucleotide binding protein (G protein) alpha more	79.27(n) 85.83(a)		503589 NM_001013277.2 NP_001013295.1
fruit fly (Drosophila melanogaster)	Insecta	cta³	G-protein coupled receptor protein signaling pathway more	53(a)		2 40 (determined by in situ hybridization) --
worm (Caenorhabditis elegans)	Secernentea	gpa-12^{1 , 3}	guanine nucleotide-binding protein³ Protein GPA-12¹	51(a) (best of 2)³ 53.16(n)¹ 52.19(a)¹		X(9282179-9283774)³ 181157¹ NM_077156.2¹ NP_509557.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	XLG2⁶ GPA1⁶ (see all 4)	extra-large GTP-binding protein 2 guanine nucleotide-binding protein alpha-1 subunit... (see all 4)	8(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	4(16441179-16445005) 2(11196996-11201102)
rice (Oryza sativa)	Liliopsida	XA7⁶ -- (see all 5)	G-protein alpha subunit, putative, expressed (see all 5)	24(a) 16(a) (see all 5)	many ↔ many many ↔ many (see all 5)	5(15552385-15556024) 10(1125704-1130461)

ENSEMBL Gene Tree for GNA12 (if available)
TreeFam Gene Tree for GNA12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GNA12 gene

GNAQ² GNA14² GNA11² GNAI3² GNAT2² GNA13² GNAT3² GNAT1²

GNAI2² GNA15² GNAZ² GNAO1² GNAI1²

18 SIMAP similar genes for GNA12 using alignment to 7 protein entries: GNA12_HUMAN (see all proteins):

GNA13 GNAI3 GNA11 GNAI1 GNAT3 GNA14

GNAI2 GNAO1 GNAQ GNAT1 GNAZ GNAT2

GNA15 DKFZp686O0962 GNAS GSA GNAL WUGSC

GNA12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190987376^1,2		--	2767261(+)	`CTCCCA/CAAGTG`	1	--	int¹		0	--	--	--	--
rs148250999^1,2		--	2767313(+)	`GGTTCC/TCCTAC`	1	--	int¹		0	--	--	--	--
rs62441390^1,2		--	2767321(+)	`TACATA/GCCAGG`	1	--	int¹		1		NA	2
rs150226687^1,2		--	2767449(+)	`GGCTGC/TGGGAG`	1	--	int¹		0	--	--	--	--
rs184025684^1,2		--	2767486(+)	`GGAGAC/TAGAGA`	1	--	int¹		0	--	--	--	--
rs7800633^1,2	C,F,A,	--	2767605(+)	`AGAATC/TGTTTG`	1	--	int¹		7		NA WA CSA EA	366
rs798534^1,2	C,F,A,H,	--	2767607(-)	`TTCAAG/ACGATT`	1	--	int¹		15		NS EA NA WA CSA	784
rs188573837^1,2		--	2767692(+)	`AATCCC/TGGGGA`	1	--	int¹		0	--	--	--	--
rs77511623^1,2	F,	--	2767705(+)	`GAAAAA/GTCAAT`	1	--	int¹		1		WA	118
rs192945328^1,2		--	2767870(+)	`GACCCA/GGACCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GNA12 (2767739 - 2883959 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GNA12
1 CNV: 30255

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNA12

DNA2.0 Custom Variant and Variant Library Synthesis for GNA12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNA12 for disorders           About GeneDecksing

OMIM gene information: 604394    OMIM disorders: --

14 diseases for GNA12:    About MalaCards

familial hyperaldosteronism hyperaldosteronism fainting azoospermia

astrocytoma lung cancer prostate cancer breast cancer

fibrosis prostatitis leukemia neuronitis

huntington's disease retinitis

Genetic Association Database (GAD): GNA12
Human Genome Epidemiology (HuGE) Navigator: GNA12 (7 documents)

Export disorders for GNA12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNA12 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with GNA12)

Utopia: connect your pdf to the dynamic
world of online information

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product. (PubMed id 8423800)^{1, 2, 3} Chan A.M.-L....Aaronson S.A. (1993)
Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. (PubMed id 15221642)^{1, 4, 9} Iida A....Nakamura Y. (2004)
Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3. (PubMed id 16247467)^{1, 3} Kumar R.N....Dhanasekaran N. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (PubMed id 18307725)^{1, 9} Jeske Y.W....Stowasser M. (2008)
Ga12 activation in podocytes leads to cumulative chang es in glomerular collagen expression, proteinuria and glomerulosclerosis. (PubMed id 22249312)¹ Boucher I....Denker B.M. (2012)
Translational analysis of mouse and human placental pr otein and mRNA reveals distinct molecular pathologies in human preeclampsia. (PubMed id 21986993)¹ Cox B....Kislinger T. (2011)
Neoplastic transformation induced by the gep oncogene s involves the scaffold protein JNK-interacting leucine zipper protein. (PubMed id 21472140)¹ Kashef K....Dhanasekaran D.N. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2768	HGNC: 4380	AceView: GNA12	Ensembl:ENSG00000146535	euGenes: HUgn2768
ECgene: GNA12	Kegg: 2768	H-InvDB: GNA12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNA12	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GNA12	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GNA12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GNA12 gene:
Search GeneIP for patents involving GNA12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNA12		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNA12
	OriGene Protein Over-expression Lysate for GNA12		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GNA12		OriGene 3'-UTR Clone for GNA12
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNA12
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GNA12		OriGene Custom Protein Services for GNA12
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNA12
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNA12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA12
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNA12
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNA12
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNA12

	GenScript Custom Purified and Recombinant Proteins Services for GNA12		GenScript cDNA clones with any tag delivered in your preferred vector for GNA12
	GenScript Custom Assay Services for GNA12		GenScript Custom Superior Antibodies Services for GNA12
	GenScript Custom overexpressing Cell Line Services for GNA12		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GNA12 promoter
	Search Chromatin IP Primers for GNA12
	RT² qPCR Primer Assay in human, mouse, rat GNA12
	Search GNC Networks for GNA12
	SABiosciences PCR Arrays including human, mouse, rat GNA12

Tocris compounds for GNA12

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GNA12 antibodies
	GNA12 proteins
	GNA12 lysates

	Antibodies for GNA12
	See all of Abcam's Antibodies, Kits and Proteins for GNA12
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GNA12

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA12

	Browse SwitchGear 3'UTR luciferase reporter plasmids for GNA12
	SwitchGear Promoter luciferase reporter plasmids for GNA12

ThermoFisher Antibodies for GNA12

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA12

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GNA12 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GNA12 Gene

guanine nucleotide binding protein (G protein) alpha 12

Aliases
for GNA12 gene

Summaries
for GNA12 gene

Genomic Views
for GNA12 gene

Proteins
for GNA12 gene

Protein Domains /
Families
for GNA12 gene

Function
for GNA12 gene

Pathways & Interactions
for GNA12 gene

Drugs & Compounds
for GNA12 gene

Transcripts
for GNA12 gene

Expression
for GNA12 gene

Orthologs
for GNA12 gene

Paralogs
for GNA12 gene

Genomic Variants
for GNA12 gene

Disorders / Diseases
for GNA12 gene

Publications
for GNA12 gene

External Searches for GNA12 gene

Genome Databases showing GNA12 gene

Other Databases showing GNA12 gene

Specialized Databases showing GNA12 gene

Intellectual Property
for GNA12 gene

Products
for GNA12 gene

View Random Gene

Advanced Search

Export list of displayed genes

GNA12 Gene

guanine nucleotide binding protein (G protein) alpha 12

Aliasesfor GNA12 gene

Summariesfor GNA12 gene

Genomic Viewsfor GNA12 gene

Proteinsfor GNA12 gene

Protein Domains /Familiesfor GNA12 gene

Functionfor GNA12 gene

Pathways & Interactionsfor GNA12 gene

Drugs & Compoundsfor GNA12 gene

Transcriptsfor GNA12 gene

Expression for GNA12 gene

Orthologsfor GNA12 gene

Paralogsfor GNA12 gene

Genomic Variantsfor GNA12 gene

Disorders / Diseasesfor GNA12 gene

Publicationsfor GNA12 gene

External Searches for GNA12 gene

Genome Databases showing GNA12 gene

Other Databases showing GNA12 gene

Specialized Databases showing GNA12 gene

Intellectual Propertyfor GNA12 gene

Productsfor GNA12 gene

View Random Gene

Aliases
for GNA12 gene

Summaries
for GNA12 gene

Genomic Views
for GNA12 gene

Proteins
for GNA12 gene

Protein Domains /
Families
for GNA12 gene

Function
for GNA12 gene

Pathways & Interactions
for GNA12 gene

Drugs & Compounds
for GNA12 gene

Transcripts
for GNA12 gene

Expression
for GNA12 gene

Orthologs
for GNA12 gene

Paralogs
for GNA12 gene

Genomic Variants
for GNA12 gene

Disorders / Diseases
for GNA12 gene

Publications
for GNA12 gene

Intellectual Property
for GNA12 gene

Products
for GNA12 gene