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GNA12 Gene

protein-coding   GIFtS: 66
GCID: GC07M002767

Guanine Nucleotide Binding Protein (G Protein) Alpha 12

  See GNA12-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Nucleotide Binding Protein (G Protein) Alpha 121 2     RMP2
G Alpha-122 3     WUGSC:H_GS165O14.22
G-Protein Subunit Alpha-122 3     gep2
NNX32     Guanine Nucleotide-Binding Protein Subunit Alpha-122

External Ids:    HGNC: 43801   Entrez Gene: 27682   Ensembl: ENSG000001465357   OMIM: 6043945   UniProtKB: Q031133   

Export aliases for GNA12 gene to outside databases

Previous GC identifers: GC07M002415 GC07M002515 GC07M002512 GC07M002540 GC07M002734 GC07M002686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GNA12 Gene:
GNA12 (guanine nucleotide binding protein (G protein) alpha 12) is a protein-coding gene. Diseases associated with GNA12 include familial hyperaldosteronism. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling
cascade

summary for GNA12 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved
in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including
cytoskeletal rearrangement and oncogenic transformation.

Gene Wiki entry for GNA12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNA12 gene promoter:
         HFH-3   Bach2   CUTL1   HNF-1A   FOXI1   AREB6   HNF-1   Zic1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): GNA12 promoter sequence
   Search Chromatin IP Primers for GNA12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNA12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.2   Ensembl cytogenetic band:  7p22.2   HGNC cytogenetic band: 7p22.3

GNA12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M002767:  view genomic region     (about GC identifiers)

Start:
2,767,739 bp from pter      End:
2,883,959 bp from pter
Size:
116,221 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 2,815,641-2,931,835     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-12  
Size: 381 amino acids; 44279 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine
nucleotide binding site. Interacts with UBXD5. Interacts (when active) with PPP5C (via TPR repeats); activates
PPP5C phosphatase activity and translocates PPP5C to the cell membrane
Secondary accessions: A4D204 Q2T9L1 Q86UM8 Q8TD71 Q9UDU9

Explore the universe of human proteins at neXtProt for GNA12: NX_Q03113

Explore proteomics data for GNA12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GNA12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269369.1  NP_001269370.1  NP_031379.2  

    ENSEMBL proteins: 
     ENSP00000275364   ENSP00000385935   ENSP00000386054   ENSP00000391462   ENSP00000437469  
     ENSP00000380160  
    Reactome Protein details: Q03113

    GNA12 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GNA12
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    Novus Biologicals GNA12 Protein
    Novus Biologicals GNA12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GNA12 

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    Search eBioscience for ELISAs for GNA12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001019 Gprotein_alpha_su
     IPR011025 GproteinA_insert
     IPR027417 P-loop_NTPase
     IPR000469 Gprotein_alpha_12

    Graphical View of Domain Structure for InterPro Entry Q03113

    ProtoNet protein and cluster: Q03113

    2 Blocks protein domains:
    IPB000469 G-protein alpha subunit group 12 signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA12_HUMAN, Q03113
    Similarity: Belongs to the G-alpha family. G(12) subfamily


    Find genes that share domains with GNA12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNA12_HUMAN, Q03113
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling
    cascade

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding ----
    GO:0003924GTPase activity IBA--
    GO:0004871signal transducer activity IBA--
    GO:0005515protein binding IPI10026210
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with GNA12           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GNA12:
     Bright nuclei  Decreased Salmonella enterica   Synthetic lethal with c-Myc af 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gna12):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal 

    Find genes that share phenotypes with GNA12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gna12tm1Citb for GNA12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNA12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNA12

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNA12

    miRNA
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    miRTarBase miRNAs that target GNA12:
    hsa-mir-149-5p (MIRT045616), hsa-mir-98-5p (MIRT027790), hsa-mir-93-5p (MIRT028098), hsa-mir-124-3p (MIRT023075), hsa-mir-23b-3p (MIRT046311)

    Block miRNA regulation of human, mouse, rat GNA12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNA12 (see all 39):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-507 hsa-miR-424 hsa-miR-1244 hsa-miR-15b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA12
    Addgene plasmids for GNA12 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNA12_HUMAN, Q03113: Membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    plasma membrane3
    peroxisome2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IBA--
    GO:0031526brush border membrane IBA--

    Find genes that share ontologies with GNA12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNA12 About   (see all 51)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    Relaxin Pathway0.37
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.32
    CRHR Pathway0.44
    4S1P3 pathway
    S1P3 pathway0.44
    S1P4 pathway0.36
    S1P2 pathway0.44
    S1P5 pathway0.00
    Sphingosine 1-phosphate (S1P) pathway0.40
    5fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.30
    fMLP Pathway0.43


    Find genes that share SuperPaths with GNA12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GNA12 (see all 66)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Visual Cycle in Retinal Rods
    CDK5 Pathway
    JNK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GNA12 (see all 8)
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Signal transduction PKA signaling
    Development G-Proteins mediated regulation MARK-ERK signaling
    Cell adhesion Integrin inside-out signaling

    Selected BioSystems Pathways for GNA12 (see all 11)
        MAPK signaling pathway
    G Protein Signaling Pathways
    Regulation of Actin Cytoskeleton
    TSH signaling pathway
    LPA receptor mediated events

    2 Reactome Pathways for GNA12
        G alpha (12/13) signalling events
    Thrombin signalling through proteinase activated receptors (PARs)

    1 PharmGKB Pathway for GNA12
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for GNA12):
        MAPK signaling pathway
    Vascular smooth muscle contraction
    Long-term depression
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNA12
    Interactions:

        Search GeneGlobe Interaction Network for GNA12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GNA12 (Q031132, 3 ENSP000002753644) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301532, 3, ENSP000003248044MINT-8239002 I2D: score=3 STRING: ENSP00000324804
    ARHGEF1Q928882, 3, ENSP000003372614MINT-7909421 I2D: score=1 STRING: ENSP00000337261
    ARHGEF11O150853, ENSP000003571774I2D: score=3 STRING: ENSP00000357177
    CDH15P552913, ENSP000002897464I2D: score=3 STRING: ENSP00000289746
    CDH2P190223, ENSP000002691414I2D: score=3 STRING: ENSP00000269141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway TAS8290554
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA--
    GO:0007264small GTPase mediated signal transduction ----

    Find genes that share ontologies with GNA12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GNA12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    3 HMDB Compounds for GNA12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNA12 gene (3 alternative transcripts): 
    NM_001282440.1  NM_001282441.1  NM_007353.2  

    Unigene Cluster for GNA12:

    Guanine nucleotide binding protein (G protein) alpha 12
    Hs.487341  [show with all ESTs]
    Unigene Representative Sequence: NM_007353
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275364(uc003smu.3 uc011jwb.2) ENST00000491117 ENST00000407904(uc003smt.3)
    ENST00000407653 ENST00000496740 ENST00000471281 ENST00000485329 ENST00000447791
    ENST00000544127 ENST00000396960
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GNA12 (see all 39):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-507 hsa-miR-424 hsa-miR-1244 hsa-miR-15b
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GNA12 (NM_007353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNA12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNA12
    Addgene plasmids for GNA12 
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      QuantiTect SYBR Green Assays in human, mouse, rat GNA12
      QuantiFast Probe-based Assays in human, mouse, rat GNA12

    Additional mRNA sequence: 

    AF493901.1 AK024696.1 AK024834.1 AK025582.1 AK025894.1 AK122830.1 AK127842.1 AK128701.1 
    AK295830.1 AL512719.1 BC007400.2 BC009457.1 BC063396.1 BC087537.1 BC111464.1 L01694.1 
    XR_158813.2 XR_159074.2 XR_159474.2 XR_171621.1 

    18 DOTS entries:

    DT.101983287  DT.444259  DT.100821049  DT.101983288  DT.429058  DT.95365859  DT.121071657  DT.121071708 
    DT.95365860  DT.100821048  DT.100821052  DT.121071652  DT.121071688  DT.40127457  DT.91755629  DT.95320949 
    DT.95361660  DT.100713633 

    Selected AceView cDNA sequences (see all 303):

    CR622889 CD675462 CD300413 AA485595 W63683 BQ691191 BM819097 AK127842 
    AI381970 BQ945577 AI122954 BQ212137 BU859761 AI885828 AA565077 BE536893 
    CB152014 NM_007353 AW085139 Z39001 AI743232 CA390161 BQ004657 AI357335 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNA12 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                      -     -     -     -     -     -     -                                       
    SP2:        -     -     -                 -     -     -     -     -     -     -                                       
    SP3:                                                              -           -                                       
    SP4:              -     -                       -     -     -     -     -     -                                       
    SP5:                                                              -     -     -                                       


    ECgene alternative splicing isoforms for GNA12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GNA12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCGGGGTGA
    GNA12 Expression
    About this image


    GNA12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Ovary (Reproductive System)
     
     Placenta (Extraembryonic Tissues)
    GNA12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNA12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487341
        Custom PCR Arrays for GNA12
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GNA12 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gna121 , 5 guanine nucleotide binding protein, alpha 121, 5 90.15(n)1
    95.78(a)1
      5 (79.30 cM)5
    146731  NM_010302.21  NP_034432.11 
     1407584085 
    chicken
    (Gallus gallus)
    Aves GNA121 guanine nucleotide binding protein (G protein) alpha more 80.75(n)
    92.39(a)
      769924  XM_001233236.3  XP_001233237.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNA126
    guanine nucleotide binding protein (G protein) alp...
    92(a)
    1 ↔ 1
    GL343340.1(399517-410617)
    zebrafish
    (Danio rerio)
    Actinopterygii gna12a1 guanine nucleotide binding protein (G protein) alpha more 79.09(n)
    85.83(a)
      503589  NM_001013277.2  NP_001013295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cta3 G-protein coupled receptor protein
    signaling pathway more
    53(a)   2 40 (determined by in situ hybridization)   --
    worm
    (Caenorhabditis elegans)
    Secernentea gpa-121 , 3 guanine nucleotide-binding protein3
    gpa-121
    51(a)
    (best of 2)3
    53.49(n)1
    52.51(a)1
      X(9282179-9283774)3
    1811571  NM_077156.31  NP_509557.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPA26
    Nucleotide binding alpha subunit of the heterotrim...
    29(a)
    1 → many
    V(195168-196517) YER020W


    ENSEMBL Gene Tree for GNA12 (if available)
    TreeFam Gene Tree for GNA12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNA12 gene
    GNAQ2  GNA112  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  
    GNAI22  GNA152  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNA12 using alignment to 7 protein entries:     GNA12_HUMAN (see all proteins):
    GNA13    GNAI3    GNA11    GNAI1    GNAT3    GNA14
    GNAI2    GNAO1    GNAQ    GNAT1    GNAZ    GNAT2
    GNA15    DKFZp686O0962    GNAS    GSA    GNAL    WUGSC

    Find genes that share paralogs with GNA12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNA12 (see all 3226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909873761,2
    --2767261(+) CTCCCA/CAAGTG 1 -- int10--------
    rs1482509991,2
    --2767313(+) GGTTCC/TCCTAC 1 -- int10--------
    rs624413901,2
    C,F--2767321(+) TACATA/GCCAGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1502266871,2
    C--2767449(+) GGCTGC/TGGGAG 1 -- int10--------
    rs1840256841,2
    --2767486(+) GGAGAC/TAGAGA 1 -- int10--------
    rs78006331,2
    C,F,A--2767605(+) agaatC/Tgtttg 1 -- int17Minor allele frequency- T:0.43NA WA CSA EA 366
    rs7985341,2
    C,F,A,H--2767607(-) ttcaaG/Acgatt 1 -- int115Minor allele frequency- A:0.38NS EA NA WA CSA 784
    rs1885738371,2
    --2767692(+) AATCCC/TGGGGA 1 -- int10--------
    rs775116231,2
    C,F--2767705(+) GAAAAA/GTCAAT 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1929453281,2
    --2767870(+) GACCCA/GGACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GNA12 (2767739 - 2883959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNA12:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7123n71CNV Loss21882294
    nsv471227CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GNA12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604394    OMIM disorders: --

    1 disease for GNA12:    
    About MalaCards
    familial hyperaldosteronism


    Find genes that share disorders with GNA12           About GenesLikeMe

    Genetic Association Database (GAD): GNA12
    Human Genome Epidemiology (HuGE) Navigator: GNA12 (7 documents)

    Export disorders for GNA12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNA12 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with GNA12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product. (PubMed id 8423800)1, 2, 3 Chan A.M.-L....Aaronson S.A. (Mol. Cell. Biol. 1993)
    2. Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. (PubMed id 15221642)1, 4, 9 Iida A....Nakamura Y. (J. Hum. Genet. 2004)
    3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    4. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PubMed id 19343178)1, 4 Soranzo N....Deloukas P. (PLoS Genet. 2009)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    9. Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3. (PubMed id 16247467)1, 3 Kumar R.N....Dhanasekaran N. (Oncogene 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2768 HGNC: 4380 AceView: GNA12 Ensembl:ENSG00000146535 euGenes: HUgn2768
    ECgene: GNA12 Kegg: 2768 H-InvDB: GNA12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNA12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GNA12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNA12 gene:
    Search GeneIP for patents involving GNA12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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