Aliases for GNA12 Gene
External Ids for GNA12 Gene
Previous GeneCards Identifiers for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are CCR5 Pathway in Macrophages and Vascular smooth muscle contraction. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNA13.
UniProtKB/Swiss-Prot for GNA12 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.