Aliases for GNA12 Gene
External Ids for GNA12 Gene
Previous GeneCards Identifiers for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (Guanine Nucleotide Binding Protein (G Protein) Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include familial hyperaldosteronism. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNA12 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galpha12/13 are involved in Rho family GTPase signalling and have been linked to several cellular regulatory processes, including cytoskeletal rearrangement and oncogenic transformation.