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GNA11 Gene

protein-coding GIFtS: 65

GC19P003045

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GA11 ^³
GNA-11 ^²

Descriptions
G alpha-11 ^³
G-protein subunit alpha-11 ^³
Guanine nucleotide-binding protein G(y) subunit alpha ^³
guanine nucleotide binding protein (G protein), alpha 11 (Gq class) ^²
guanine nucleotide-binding protein, Gq class, GNA11 ^²

External Ids
HGNC: 4379¹
Entrez Gene: 2767²
UniProtKB: P29992³
Ensembl: ENSG00000088256⁷

Search outside databases for aliases for GNA11 gene

Previous GC identifers: GC19P003213 GC19P003163 GC19P003034

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C

Gene Wiki entry for GNA11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNA11 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

GNA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P003045: (about GC identifiers)

Start:	3,045,408 bp from pter
End:	3,072,468 bp from pter
Size:	27,061 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992 (See protein sequence)

Recommended Name: Guanine nucleotide-binding protein subunit alpha-11

Size: 359 amino acids; 42123 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the

guanine nucleotide binding site

Secondary accessions: O15109 Q14350 Q6IB00

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002058.2

ENSEMBL proteins:

ENSP00000078429

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam ( GNAQ+ GNA11 )
	Human Recombinant Proteins from Abnova (GNA11)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9175863
GO:0005886	plasma membrane	TAS	9175863

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Antibodies for GNA11:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GNA11
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam ( GNAQ+ GNA11 ), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GNA11

Assays for GNA11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P29992

ProtoNet protein and cluster: P29992

2 Blocks protein families:

IPB000654 G-protein alpha subunit group Q signature

IPB001019 Alpha G-protein (transducin) signature

UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992

Similarity: Belongs to the G-alpha family. G(q) subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNA11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNA11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002067

Applied Biosystems Silencer® siRNAs for GNA11

Sigma-Aldrich siRNA for GNA11

Sigma-Aldrich shRNA Panels and shRNA for GNA11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GNA11
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002067
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002067
untagged cDNA clone in CMV expression vector: NM_002067

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002067

UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or

transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C

Genatlas biochemistry entry for GNA11:

guanine nucleotide binding protein (G protein),alpha 11 (Gq class),mediating pertussis

toxin-resistant stimulation of phospholipase C beta

15/22 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gna11) (see all 22 ):

	behavior/neurological	craniofacial	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle	nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	8530500
GO:0004871	signal transducer activity	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0019001	guanyl nucleotide binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for GNA11 (Your Favorite Gene powered by Ingenuity) (see all 17 )

CXCR4 Signaling
Cardiac Hypertrophy Signaling
Endothelin-1 Signaling
Ephrin Receptor Signaling
GNRH Signaling

GeneDecks GNA11 for the pathways selected above

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5/81 Interacting proteins for GNA11 (ENSP00000078429³) via UniProtKB, MINT, and/or STRING (see all 81 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDNRB	ENSP00000366416³	STRING (score=.994)
EDNRA	ENSP00000315011³	STRING (score=.989)
TBXA2R	ENSP00000248419³	STRING (score=.96)
LPAR2	ENSP00000351659³	STRING (score=.938)
AGTR1	ENSP00000273430³	STRING (score=.935)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0001508	regulation of action potential	IEA	--
GO:0006471	protein amino acid ADP-ribosylation	IEA	--
GO:0007165	signal transduction	TAS	8530500
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GNA11 available from Tocris Bioscience

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNA11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GNA11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002067

Sigma-Aldrich siRNA for GNA11

Sigma-Aldrich shRNA Panels and shRNA for GNA11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002067

REFSEQ mRNAs for GNA11 gene:

NM_002067.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002067

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002067
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002067
                                 untagged cDNA clone in CMV expression vector: NM_002067

Additional cDNA sequence:

AL110227.1 BC001528.2 BC051315.1 BC063426.1 BC111027.1

11 DOTS entries:

DT.95121107 DT.95121117 DT.95154856 DT.121464340 DT.453055 DT.70101545 DT.87014967 DT.95097490

DT.99953757 DT.92340108 DT.97781328

24/340 AceView cDNA sequences (see all 340 ):

T06575 AW068937 BU615875 BM794330 CA443547 AI139611 CA444441 BQ129360

AI203547 BM721678 AI245200 AF493900 BI917403 BU149324 BM556571 BQ638343

BF111816 BE740136 BQ959092 BQ882612 AA378440 AI040021 H00527 BM560891

highest scoring ESTs for GNA11:

M69013 AK091639 AA161147 BC036914 BQ373387 CB162847 AA302162 AF011499 AW675127 BG978952

Unigene Clusters for GNA11:

Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

Hs.650575 [show with all ESTs], Hs.654784 [show with all ESTs]

Unigene Representative Sequences: NM_002067, AL110227

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GNA11

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b
SP1:									-		-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for GNA11

1 Ensembl transcript including schematic representation:

ENST00000078429

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GNA11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNA11

¹ / ² / ³

19 probe-sets matching GNA11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59679_at²^{, 3}	U95-C	1	1.00	1.00	0.79	1.33	AI679110	0.20	0.50	0.38	1
57231_at²^{, 3}	U95-C	1	1.00	1.00	0.81	1.34	AI983784	0.60	0.60	0.60	1
55214_at²^{, 3}	U95-C	1	1.00	1.00	0.21	0.81	AI310005	0.60	0.75	0.68	1
564_at²^{, 3}	U133-A	3	1.00	0.89	0.62	0.76	M69013	0.80	1.00	0.91	1
89107_s_at²^{, 3}	U95-D	3	1.00	0.76	0.38	1.00	AA161147	0.40	1.00	0.76	1
41476_at²^{, 3}	U95-A	1	0.94	1.00	0.81	1.14	N36926	0.60	0.60	0.60	1
40562_at²^{, 3}	U133-A	3	0.81	0.81	0.56	0.66	AF011499	0.20	1.00	0.72	1
213944_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG236220	0.40	0.50	0.45	1
213766_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N36926	0.60	0.60	0.60	1
204248_at²^{, 3}	U133-A	3	1.00	0.91	--	--	NM_002067	0.40	0.67	0.55	1
564_at²^{, 3}	U133-A	3	1.00	0.89	--	--	M69013	0.80	1.00	0.91	1
214679_x_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AL110227	0.40	0.50	0.45	1
40562_at²^{, 3}	U133-A	3	0.81	0.81	--	--	AF011499	0.20	1.00	0.72	1
213944_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213766_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204248_at²	U133Plus2	3	1.00	0.91	--	--	--	--	--	--	--
564_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
214679_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
40562_at²	U133Plus2	2	0.81	0.85	--	--	--	--	--	--	--

GeneDecks GNA11 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTGTGCGC

SOURCE GeneReport for Unigene clusters: Hs.650575 Hs.654784
Expression variation in blood from EXPOLDB for GNA11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GNA11 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNA11¹	--	guanine nucleotide binding protein (G protein), alpha more	93.13(n) 98.33(a)	403914 XM_533951.2 XP_533951.2
cow (Bos taurus)	GNA11¹	--	guanine nucleotide binding protein (G protein), alpha more	92.92(n) 98.58(a)	281788 NM_174322.2 NP_776747.1
rat (Rattus norvegicus)	Gna11¹	--	guanine nucleotide binding protein, alpha 11	89.23(n) 96.66(a)	81662 NM_031033.1 NP_112295.1
mouse (Mus musculus)	Gna11^{1, 5}	10 (43.00 cM)⁵	guanine nucleotide binding protein, alpha 11^{1, 5}	89.6(n)¹ 98.05(a)¹	14672¹ NM_010301.3¹ NP_034431.1¹ AA106989⁵ AK088773⁵ (see all 17)
chicken (Gallus gallus)	GNA11¹	--	guanine nucleotide binding protein (G protein), alpha more	82.64(n) 97.21(a)	374077 NM_204234.1 NP_989565.1

About this table Species with no ortholog for GNA11

ENSEMBL Gene Tree for GNA11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GNA11 gene

GNAQ² GNA14²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/228 NCBI SNPs in GNA11 are shown (see all 228 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs308040^1,2	A,C,F,H	3072908(+)	`CCTCTC/GTCATG`	1	--	ng3¹		11		MN EU EA WA NA	1194
	rs4806907^1,2	A,C,F,H	3044163(+)	`GCGTAC/TACCTG`	1	--	ng5¹		8		EU EA WA	838
--	rs11084997^1,2	A,C	3044991(+)	`CTGCTC/GCCCAG`	1	--	ng5¹		0	--	--	--	--
--	rs11084998^1,2	A,C	3045023(+)	`GCAGCA/GGCCGC`	1	--	ng5¹		0	--	--	--	--
--	rs308041^1,2	C	3072609(+)	`CCCCCC/TGTGGC`	1	--	ng3¹		0	--	--	--	--
--	rs4900^1,2	A,C,F,H	3070239(+)	`CGGACC/TATCAT`	1	T/T	syn¹ ese³		9		MN NA EU EA WA	752
--	rs2230314^1,2	F	3070326(+)	`TACTCG/CCACCT`	1	S/S	syn¹		1		MN	38
	rs308039^1,2	A,C,F,H,O	3046927(+)	`GTCACC/TCCAAA`	1	--	int¹		12		MN EA EU WA NA	2700
	rs308056^1,2	A,C,F,H,O	3057588(+)	`GCTTTG/CGTGGG`	1	--	int¹		13		MN EA NA EU WA	2370
	rs308037^1,2	A,C,F,H	3049245(+)	`GTGGCG/AAGCAC`	1	--	int¹		3		EU EA	300

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HapMap Linkage Disequilibrium images for GNA11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139313

1 PharmGKB disease relationship for GNA11 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/45 PubMed articles for GNA11 gene (see all 45 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. (PubMed id 7492305)^{3, 4} Thomas C.P.... Mattera R. (1995)
Evolution of the mammalian G protein alpha subunit multigene family. (PubMed id 1302014)^{2, 3} Wilkie T.M....Simon M.I. (1992)
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. (PubMed id 1902575)^{3, 4} Jiang M.... Fong H.K.W. (1991)
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. (PubMed id 12759536)^{1, 3} Asada K....Ushijima T. (2003)
The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis. (PubMed id 17552882)³ Durchankova D....Svoboda P. (2008)
Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. (PubMed id 18713748)³ Gavard J. and Gutkind J.S. (2008)
Phosphorylation of Galpha11 protein contributes to agonist-induced desensitization of 5-HT2A receptor signaling. (PubMed id 17056873)³ Shi J....Muma N.A. (2007)
Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors. (PubMed id 17535809)³ Hildebrand M.E....Snutch T.P. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2767	HGNC: 4379	AceView: GNA11	Ensembl:ENSG00000088256	euGenes: HUgn2767
ECgene: GNA11	H-InvDB: GNA11

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GNA11
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GNA11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNA11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNA11		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GNA11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies ( GNAQ+ GNA11 )

Search OriGene for GNA11

Tocris compounds for GNA11

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for GNA11

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GNA11 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GNA11

Summaries
for GNA11

Genomic Location
for GNA11

Proteins
for GNA11

Protein Domains/
Families
for GNA11

Gene Function
for GNA11

Pathways & Interactions
for GNA11

Drugs & Compounds
for GNA11

Transcripts
for GNA11

Expression
for GNA11

Orthologs
for GNA11

Paralogs
for GNA11

SNPs/Variants
for GNA11

Disorders & Mutations
for GNA11

Medical News
for GNA11

Publications
for GNA11

Search for GNA11

Genome Databases showing GNA11

Other Databases showing GNA11

Specialized Databases showing GNA11

Licensable Technologies
for GNA11

Services
for GNA11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNA11 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GNA11

Summariesfor GNA11

Genomic Locationfor GNA11

Proteinsfor GNA11

Protein Domains/Familiesfor GNA11

Gene Functionfor GNA11

Pathways & Interactionsfor GNA11

Drugs & Compoundsfor GNA11

Transcriptsfor GNA11

Expression for GNA11

Orthologsfor GNA11

Paralogsfor GNA11

SNPs/Variantsfor GNA11

Disorders & Mutationsfor GNA11

Medical Newsfor GNA11

Publicationsfor GNA11

Search for GNA11

Genome Databases showing GNA11

Other Databases showing GNA11

Specialized Databases showing GNA11

Licensable Technologiesfor GNA11

Servicesfor GNA11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNA11

Summaries
for GNA11

Genomic Location
for GNA11

Proteins
for GNA11

Protein Domains/
Families
for GNA11

Gene Function
for GNA11

Pathways & Interactions
for GNA11

Drugs & Compounds
for GNA11

Transcripts
for GNA11

Expression
for GNA11

Orthologs
for GNA11

Paralogs
for GNA11

SNPs/Variants
for GNA11

Disorders & Mutations
for GNA11

Medical News
for GNA11

Publications
for GNA11

Licensable Technologies
for GNA11

Services
for GNA11