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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNA11 Gene

protein-coding   GIFtS: 64
GCID: GC19P003094

guanine nucleotide binding protein (G protein), alpha 11...

 Explore 18 diseases affiliated with
GNA11 via our new
 Human Malady Compendium 
Biological research products
for GNA11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein (G Protein), Alpha 11 (Gq Class)1 2     GNA-112
G Alpha-112 3     Guanine Nucleotide-Binding Protein Subunit Alpha-112
Guanine Nucleotide-Binding Protein G(Y) Subunit Alpha2 3     Guanine Nucleotide-Binding Protein, Gq Class, GNA112
G-Protein Subunit Alpha-112 3     GA113

External Ids:    HGNC: 43791   Entrez Gene: 27672   Ensembl: ENSG000000882567   OMIM: 1393135   UniProtKB: P299923   

Export aliases for GNA11 gene to outside databases

Previous GC identifers: GC19P003213 GC19P003163 GC19P003034 GC19P003045 GC19P002861


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane signaling systems. Acts as an activator of phospholipase C

summary for GNA11:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphaq/11 stimulates
PLCbeta which catalyses the hydrolysis of PIP2 to the second messengers IP3 and DAG.

Gene Wiki entry for GNA11


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNA11 gene promoter:
         Pax-5   p53   Pax-2   Pax-2a   HEN1   CREB   deltaCREB   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GNA11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GNA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNA11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003094:  view genomic region     (about GC identifiers)

Start:
3,094,408 bp from pter      End:
3,124,002 bp from pter
Size:
29,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein subunit alpha-11  
Size: 359 amino acids; 42123 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide
binding site
Subcellular location: Cell membrane; Lipid-anchor (Probable)
Secondary accessions: O15109 Q14350 Q6IB00

Explore the universe of human proteins at neXtProt for GNA11: NX_P29992

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29992

  • GNA11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002058.2  
    ENSEMBL proteins: 
     ENSP00000078429   ENSP00000465935  
    Reactome Protein details: P29992
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm TAS9175863
    GO:0005834heterotrimeric G-protein complex IBA--
    GO:0005886plasma membrane TAS--
    GO:0031234extrinsic to internal side of plasma membrane IBA--


    GNA11 for ontologies           About GeneDecksing



    GNA11 Antibody Products: 
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    Assay Products for GNA11: 
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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GNA11 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001019 Gprotein_alpha_su
     IPR000654 Gprotein_alpha_Q
     IPR011025 GproteinA_insert

    Graphical View of Domain Structure for InterPro Entry P29992

    ProtoNet protein and cluster: P29992

    2 Blocks protein families:
    IPB000654 G-protein alpha subunit group Q signature
    IPB001019 Alpha G-protein (transducin) signature


    UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992
    Similarity: Belongs to the G-alpha family. G(q) subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GNA11_HUMAN, P29992
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
    transmembrane signaling systems. Acts as an activator of phospholipase C

         Genatlas biochemistry entry for GNA11:
    guanine nucleotide binding protein (G protein),alpha 11 (Gq class),mediating pertussis toxin-resistant stimulation of
    phospholipase C beta

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GNA11:
    hsa-miR-548d-3p hsa-miR-331-3p
    SwitchGear 3'UTR luciferase reporter plasmidGNA11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA11

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0003924GTPase activity TAS8530500
    GO:0004871signal transducer activity IBA--
    GO:0005525GTP binding IEA--
    GO:0031683G-protein beta/gamma-subunit complex binding IBA--


    GNA11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for GNA11:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Gna11tm1Soff for GNA11
         15/21 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gna11) (see all 21):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    GNA11 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/65 super-pathways (see all 65About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    Development Angiotensin activation of ERK1.00
    Development_EDNRB signaling0.54
    Development_Angiotensin activation of ERK0.98
    Development EDNRB signaling0.54
    Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    Cholinergic synapse0.30
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    2Development_Endothelin-1/EDNRA transactivation of EGFR
    Development_Endothelin-1/EDNRA transactivation of EGFR1.00
    Development_Endothelin-1/EDNRA signaling0.41
    Development Endothelin-1/EDNRA transactivation of EGFR1.00
    Cytoskeleton remodeling_FAK signaling0.41
    Development Endothelin-1/EDNRA signaling0.41
    Cytoskeleton remodeling FAK signaling0.41
    3G-Beta Gamma Signaling
    G-Beta Gamma Signaling1.00
    Relaxin Pathway0.32
    GHRH Signaling0.46
    Hedgehog Signaling in Mammals0.22
    CRHR Pathway0.44
    4CCR3 Pathway in Eosinophils
    CCR3 Pathway in Eosinophils1.00
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Huntington's Disease Pathway0.18
    fMLP Pathway0.43
    5Translation_Translation regulation by Alpha-1 adrenergic receptors
    Translation_Translation regulation by Alpha-1 adrenergic receptors1.00
    Development_Activation of ERK by Alpha-1 adrenergic receptors0.64
    Translation Translation regulation by Alpha-1 adrenergic receptors1.00
    Development Activation of ERK by Alpha-1 adrenergic receptors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/20 EMD Millipore Pathways for GNA11 (see all 20)
        Transcription Transcription factor Tubby signaling pathways
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling

    5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNA11 (see all 63)
        RhoA Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for GNA11
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/21 GeneGo (Thomson Reuters) Pathways for GNA11 (see all 21)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Angiotensin signaling via PYK2
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/7 BioSystems Pathways for GNA11 (see all 7
        G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    S1P2 pathway
    Sphingosine 1-phosphate (S1P) pathway
    Arf6 signaling events

    5/18        Reactome Pathways for GNA11 (see all 18)
        Metabolism
    Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
    Regulation of Insulin Secretion
    Regulation of Insulin Secretion by Free Fatty Acids
    Regulation of Insulin Secretion by Acetylcholine

    1 PharmGKB Pathway for GNA11
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for GNA11) (see all 8):
        Calcium signaling pathway
    Vascular smooth muscle contraction
    Gap junction
    Cholinergic synapse
    Long-term depression


    GNA11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for GNA11 (P299923 ENSP000000784294) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS3P497963, ENSP000002594064I2D: score=4 STRING: ENSP00000259406
    ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
    EDNRBP245303, ENSP000003353114I2D: score=2 STRING: ENSP00000335311
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    CHRM2P081723, ENSP000003199844I2D: score=1 STRING: ENSP00000319984
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001508regulation of action potential IBA--
    GO:0006184GTP catabolic process TAS8530500
    GO:0006471protein ADP-ribosylation IEA--
    GO:0007165signal transduction TAS8530500


    GNA11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNA11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GNA11

    Compounds for GNA11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Mastoparan XG protein activator peptide[72093-22-2]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]

    3 HMDB Compounds for GNA11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about GNA11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNA11 gene: 
    NM_002067.2  

    Unigene Clusters for GNA11:

    Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
    Hs.650575  [show with all ESTs], Hs.654784  [show with all ESTs]
    Unigene Representative Sequences: NM_002067, AL110227
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000078429(uc002lxd.3) ENST00000586763 ENST00000587636 ENST00000588401
    ENST00000590534 ENST00000586180 ENST00000591301

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    Inhib. RNA
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    Additional cDNA sequence: 

    AL110227.1 BC001528.2 BC051315.1 BC063426.1 BC111027.1 

    11 DOTS entries:

    DT.95121107  DT.95121117  DT.95154856  DT.121464340  DT.453055  DT.70101545  DT.87014967  DT.99953757 
    DT.92340108  DT.95097490  DT.97781328 

    24/340 AceView cDNA sequences (see all 340):

    AI203547 H00527 BQ687684 CR615254 CN484455 AI494591 BM721678 AI139611 
    AI992033 CF272489 AF493900 BI917403 BE740136 AW001941 R88684 BQ129360 
    BM560891 AA378440 CA444441 AA722486 BU149324 BU615875 AI040021 AI245200 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GNA11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                          -     -                                 
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for GNA11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTGTGCGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GNA11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNA11

    SOURCE GeneReport for Unigene clusters: Hs.650575 Hs.654784
        SABiosciences Custom PCR Arrays for GNA11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNA11 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GNA111 guanine nucleotide binding protein (G protein), alpha more 82.64(n)
    97.21(a)
      374077  NM_204234.1  NP_989565.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNA116
    --
    99(a)
    1 ↔ 1
    GL343717.1(288915-300417)
    African clawed frog
    (Xenopus laevis)
    Amphibia gna11-prov2 guanine nucleotide binding protein, alpha 11 78.43(n)    U10494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD599793.12   -- 84.03(n)    CD599793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Galpha49B3 phospholipase C activation heterotrimeric
    G-protein more
    76(a)
    (best of 3)
      49B8   --
    worm
    (Caenorhabditis elegans)
    Secernentea odr-33 guanine nucleotide-binding protein 45(a)
    (best of 6)
      V(13249483-13252134)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XLG16
    XLG26
    (see all 4)
    extra-large GTP-binding protein 2
    (see all 4)
    9(a)
    8(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2(9995478-9999122)
    4(16441179-16445005)
    rice
    (Oryza sativa)
    Liliopsida XA76
    --
    (see all 5)
    G-protein alpha subunit, putative, expressed
    (see all 5)
    28(a)
    16(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    5(15552385-15556024)
    10(1125704-1130461)


    ENSEMBL Gene Tree for GNA11 (if available)
    TreeFam Gene Tree for GNA11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNA11 gene
    GNAQ2  GNA142  GNAI32  GNAT22  GNA132  GNAT32  GNAT12  GNAI22  
    GNA152  GNA122  GNAZ2  GNAO12  GNAI12  
    18 SIMAP similar genes for GNA11 using alignment to 2 protein entries:     GNA11_HUMAN (see all proteins):
    GNAQ    GNA14    GNAI2    GNAI1    GNA15    GNAT1
    GNAT3    GNAI3    GNAT2    GNA13    GNAO1    GNA12
    DKFZp686O0962    GNAZ    GNAL    GSA    GNAS    WUGSC

    GNA11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GNA11
    PGOHUM00000232848


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/625 NCBI SNPs in GNA11 are shown (see all 625    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142734521,2
    F,--3092468(+) GGTCTC/TGAACT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1435810481,2
    --3092499(+) CTGCCA/TTGGCC 1 -- us2k10--------
    rs286850981,2
    C,--3092534(+) GGAGCC/TGCCGC 1 -- us2k19Minor allele frequency- T:0.37NA WA CSA EA 367
    rs1472056191,2
    --3092693(+) AAAAGC/GGTTTT 1 -- us2k10--------
    rs1926855281,2
    --3092700(+) TTTTCA/TGTAGT 1 -- us2k10--------
    rs1161358921,2
    F,--3092774(+) AGTAAG/AGATAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1841189221,2
    --3092852(+) CACTAC/GAGGCC 1 -- us2k10--------
    rs1865848241,2
    --3092877(+) AGCCTC/GGCCAA 1 -- us2k10--------
    rs1395120651,2
    --3092935(+) GGTGGC/TGCGCC 1 -- us2k10--------
    rs1497023791,2
    --3093096(+) TCCCTC/TGGGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNA11 (3094408 - 3124002 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GNA11
         2 CNVs: 5071 5070
    Human Gene Mutation Database (HGMD): GNA11

    3 SABiosciences Cancer Mutation PCR Assays for GNA11:
    Cosmic IdAA Change
    52974p.R183C
    21651p.R183C
    52969p.Q209L
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNA11
    DNA2.0 Custom Variant and Variant Library Synthesis for GNA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GNA11 for disorders           About GeneDecksing

    OMIM gene information: 139313    OMIM disorders: --

    18 diseases for GNA11:    About MalaCards
    mccune albright syndrome    parathyroid adenoma    fibrous dysplasia    pseudohypoparathyroidism
    fainting    chagas disease    trypanosomiasis    cholera
    adenoma    thrombosis    pertussis    pharyngitis
    breast cancer    atherosclerosis    retinitis    melanoma
    neuronitis    huntington's disease

    6 diseases from the University of Copenhagen DISEASES database for GNA11:
    Cholera     Pseudohypoparathyroidism     Pertussis     Foramen magnum meningioma
    Neuroblastoma     Fibrous dysplasia
    Human Genome Epidemiology (HuGE) Navigator: GNA11 (1 document)

    Export disorders for GNA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNA11 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with GNA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. (PubMed id 7492305)1, 2 Thomas C.P.... Mattera R. (1995)
    4. Evolution of the mammalian G protein alpha subunit multigene family. (PubMed id 1302014)1, 3 Wilkie T.M....Simon M.I. (1992)
    5. Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. (PubMed id 1902575)1, 2 Jiang M.... Fong H.K.W. (1991)
    6. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. (PubMed id 12759536)1, 9 Asada K....Ushijima T. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. High throughput mass spectrometry-based mutation profi ling of primary uveal melanoma. (PubMed id 22977135)1 Daniels A.B....Kim I.K. (2012)
    9. GNAQ and GNA11 mutations in melanocytomas of the central nervous system. (PubMed id 22307269)1 Murali R.... Bastian B.C. (2012)
    10. Identification of a preassembled TRH receptor-G(q/11) protein complex in HEK293 cells. (PubMed id 22240728)1 Drastichova Z. and Novotny J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2767 HGNC: 4379 AceView: GNA11 Ensembl:ENSG00000088256 euGenes: HUgn2767
    ECgene: GNA11 Kegg: 2767 H-InvDB: GNA11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNA11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNA11 gene:
    Search GeneIP for patents involving GNA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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