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Aliases for GMPS Gene

Aliases for GMPS Gene

  • Guanine Monophosphate Synthase 2 3 5
  • EC 6.3.5.2 4 63
  • Guanine Monophosphate Synthetase 2
  • Glutamine Amidotransferase 4
  • GMP Synthetase 4
  • GMP Synthase 2

External Ids for GMPS Gene

Previous GeneCards Identifiers for GMPS Gene

  • GC03P152441
  • GC03P156575
  • GC03P156869
  • GC03P156909
  • GC03P157071
  • GC03P155588
  • GC03P152982

Summaries for GMPS Gene

Entrez Gene Summary for GMPS Gene

  • In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMPS Gene

GMPS (Guanine Monophosphate Synthase) is a Protein Coding gene. Among its related pathways are Metabolism and One carbon pool by folate. GO annotations related to this gene include enzyme binding and transferase activity.

UniProtKB/Swiss-Prot for GMPS Gene

  • Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Gene Wiki entry for GMPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPS Gene

Genomics for GMPS Gene

Regulatory Elements for GMPS Gene

Promoters for GMPS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMPS on UCSC Golden Path with GeneCards custom track

Genomic Location for GMPS Gene

Chromosome:
3
Start:
155,869,430 bp from pter
End:
155,944,026 bp from pter
Size:
74,597 bases
Orientation:
Plus strand

Genomic View for GMPS Gene

Genes around GMPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPS Gene

Proteins for GMPS Gene

  • Protein details for GMPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49915-GUAA_HUMAN
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]
    Protein Accession:
    P49915
    Secondary Accessions:
    • A8K639
    • B4DXV7
    • F8W720

    Protein attributes for GMPS Gene

    Size:
    693 amino acids
    Molecular mass:
    76715 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GMPS Gene

    Alternative splice isoforms for GMPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMPS Gene

Proteomics data for GMPS Gene at MOPED

Post-translational modifications for GMPS Gene

  • Ubiquitination at Lys 65, Lys 182, Lys 183, Lys 204, Lys 389, Lys 412, Lys 457, and Lys 535
  • Modification sites at PhosphoSitePlus

Other Protein References for GMPS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GMPS (GMPS)

Domains & Families for GMPS Gene

Graphical View of Domain Structure for InterPro Entry

P49915

UniProtKB/Swiss-Prot:

GUAA_HUMAN :
  • Contains 1 glutamine amidotransferase type-1 domain.
Domain:
  • Contains 1 glutamine amidotransferase type-1 domain.
  • Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.
genes like me logo Genes that share domains with GMPS: view

No data available for Gene Families for GMPS Gene

Function for GMPS Gene

Molecular function for GMPS Gene

GENATLAS Biochemistry:
guanosine 5-monophosphate synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
UniProtKB/Swiss-Prot Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Enzyme Numbers (IUBMB) for GMPS Gene

Gene Ontology (GO) - Molecular Function for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003921 GMP synthase activity EXP 7706277
genes like me logo Genes that share ontologies with GMPS: view
genes like me logo Genes that share phenotypes with GMPS: view

Animal Model Products

miRNA for GMPS Gene

miRTarBase miRNAs that target GMPS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPS Gene

Localization for GMPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMPS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GMPS Gene COMPARTMENTS Subcellular localization image for GMPS gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for GMPS Gene

Pathways & Interactions for GMPS Gene

genes like me logo Genes that share pathways with GMPS: view

UniProtKB/Swiss-Prot P49915-GUAA_HUMAN

  • Pathway: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

SIGNOR curated interactions for GMPS Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006164 purine nucleotide biosynthetic process IEA --
GO:0009113 purine nucleobase biosynthetic process TAS 8089153
GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GMPS: view

Drugs & Compounds for GMPS Gene

(14) Drugs for GMPS Gene - From: HMDB, Novoseek, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Azathioprine Approved Pharma 153
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(19) Additional Compounds for GMPS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Thioguanosine monophosphate
6-Thioxanthine 5'-monophosphate
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Xanthylic acid
  • (9-D-ribosylxanthine)-5'-phosphate
  • 5'-Xanthonylate monophosphate
  • Xanthosine 5'-phosphate
  • Xanthosine-5'-P
  • Xanthosine-5'-phosphate
523-98-8
genes like me logo Genes that share compounds with GMPS: view

Transcripts for GMPS Gene

Unigene Clusters for GMPS Gene

Guanine monphosphate synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:

Relevant External Links for GMPS Gene

GeneLoc Exon Structure for
GMPS
ECgene alternative splicing isoforms for
GMPS

Expression for GMPS Gene

mRNA expression in normal human tissues for GMPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMPS Gene

This gene is overexpressed in Lymph node (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMPS Gene



SOURCE GeneReport for Unigene cluster for GMPS Gene Hs.591314

genes like me logo Genes that share expression patterns with GMPS: view

Protein tissue co-expression partners for GMPS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GMPS Gene

Orthologs for GMPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GMPS 35
  • 99.66 (n)
  • 99.86 (a)
GMPS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GMPS 36
  • 98 (a)
OneToOne
GMPS 35
  • 95.23 (n)
  • 98.83 (a)
dog
(Canis familiaris)
Mammalia GMPS 35
  • 94.57 (n)
  • 98.11 (a)
GMPS 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gmps 16
Gmps 36
  • 98 (a)
OneToOne
Gmps 35
  • 91.58 (n)
  • 97.98 (a)
oppossum
(Monodelphis domestica)
Mammalia GMPS 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GMPS 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmps 35
  • 92.02 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves GMPS 36
  • 86 (a)
OneToOne
GMPS 35
  • 82.83 (n)
  • 94.52 (a)
lizard
(Anolis carolinensis)
Reptilia GMPS 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11147 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gmps 35
  • 80.23 (n)
  • 92.35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6472 35
zebrafish
(Danio rerio)
Actinopterygii gmps 36
  • 87 (a)
OneToOne
gmps 35
  • 74.18 (n)
  • 86.99 (a)
zgc66002 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010139 35
  • 58.63 (n)
  • 61.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta bur 36
  • 58 (a)
OneToOne
bur 37
  • 58 (a)
bur 35
  • 58.23 (n)
  • 59.67 (a)
worm
(Caenorhabditis elegans)
Secernentea M106.4 35
  • 56.05 (n)
  • 54.52 (a)
gmps-1 36
  • 46 (a)
OneToOne
M106.4 37
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUA1 36
  • 42 (a)
OneToOne
GUA1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4241 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3703 36
  • 59 (a)
OneToOne
Species with no ortholog for GMPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPS Gene

ENSEMBL:
Gene Tree for GMPS (if available)
TreeFam:
Gene Tree for GMPS (if available)

Paralogs for GMPS Gene

Pseudogenes.org Pseudogenes for GMPS Gene

genes like me logo Genes that share paralogs with GMPS: view

No data available for Paralogs for GMPS Gene

Variants for GMPS Gene

Sequence variations from dbSNP and Humsavar for GMPS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs445758 -- 155,874,878(-) TGTAC(C/T)ACAAC intron-variant
rs406701 -- 155,874,039(-) agggt(A/G)ggaag intron-variant
rs2063903 -- 155,939,787(-) ACAGT(A/G)TGCTA downstream-variant-500B
rs2320318 -- 155,914,230(+) CATGA(A/G)CCACC intron-variant
rs3821365 -- 155,919,006(-) CTTTT(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMPS Gene

Variant ID Type Subtype PubMed ID
nsv877680 CNV Gain 21882294
nsv877681 CNV Loss 21882294

Variation tolerance for GMPS Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMPS Gene

HapMap Linkage Disequilibrium report
GMPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMPS Gene

Disorders for GMPS Gene

UniProtKB/Swiss-Prot

GUAA_HUMAN
  • Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

Relevant External Links for GMPS

Genetic Association Database (GAD)
GMPS
Human Genome Epidemiology (HuGE) Navigator
GMPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMPS

No disorders were found for GMPS Gene.

No data available for MalaCards and Genatlas for GMPS Gene

Publications for GMPS Gene

  1. Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. (PMID: 8089153) Hirst M. … Lou L. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Structure of a bacterial pyridoxal 5'-phosphate synthase complex. (PMID: 17159152) Strohmeier M. … Tews I. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 25 26
  3. Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase. (PMID: 16142895) Myers R.S. … Davisson V.J. (Biochemistry 2005) 23 25 26
  4. Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad. (PMID: 7907328) Boehlein S.K. … Schuster S.M. (J. Biol. Chem. 1994) 23 25 26
  5. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. (PMID: 19834552) Sarkari F. … Frappier L. (PLoS Pathog. 2009) 3 23

Products for GMPS Gene

Sources for GMPS Gene

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