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Aliases for GMPS Gene

Aliases for GMPS Gene

  • Guanine Monphosphate Synthase 2 3
  • EC 4 64
  • Guanine Monphosphate Synthetase 2
  • Glutamine Amidotransferase 4
  • GMP Synthetase 4
  • GMP Synthase 2

External Ids for GMPS Gene

Summaries for GMPS Gene

Entrez Gene Summary for GMPS Gene

  • In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GeneCards Summary for GMPS Gene

GMPS (Guanine Monphosphate Synthase) is a Protein Coding gene. Diseases associated with GMPS include leukemia, acute myeloid. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyrophosphatase activity and GMP synthase (glutamine-hydrolyzing) activity.

UniProtKB/Swiss-Prot for GMPS Gene

  • Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division

Gene Wiki entry for GMPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPS Gene

Genomics for GMPS Gene

Genomic Location for GMPS Gene

155,870,536 bp from pter
155,944,026 bp from pter
73,491 bases
Plus strand

Genomic View for GMPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GMPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPS Gene

Regulatory Elements for GMPS Gene

Proteins for GMPS Gene

  • Protein details for GMPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]
    Protein Accession:
    Secondary Accessions:
    • A8K639
    • B4DXV7
    • F8W720

    Protein attributes for GMPS Gene

    693 amino acids
    Molecular mass:
    76715 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GMPS Gene

    Alternative splice isoforms for GMPS Gene


neXtProt entry for GMPS Gene

Proteomics data for GMPS Gene at MOPED

Post-translational modifications for GMPS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65, Lys182, Lys183, Lys204, Lys389, Lys412, Lys457, and Lys535

Other Protein References for GMPS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GMPS Gene


  • Contains 1 glutamine amidotransferase type-1 domain.:
    • P49915
  • Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.:
    • P49915
genes like me logo Genes that share domains with GMPS: view

No data available for Gene Families for GMPS Gene

Function for GMPS Gene

Molecular function for GMPS Gene

GENATLAS Biochemistry: guanosine 5-monophosphate synthetase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate
UniProtKB/Swiss-Prot Function: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division

Enzyme Numbers (IUBMB) for GMPS Gene

Gene Ontology (GO) - Molecular Function for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003921 GMP synthase activity IEA --
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity IEA --
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity --
GO:0005524 ATP binding IEA --
GO:0016462 pyrophosphatase activity IEA --
genes like me logo Genes that share ontologies with GMPS: view

miRNA for GMPS Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GMPS Gene

Localization for GMPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for GMPS Gene


Subcellular locations from

Jensen Localization Image for GMPS Gene COMPARTMENTS Subcellular localization image for GMPS gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GMPS: view

Pathways for GMPS Gene

genes like me logo Genes that share pathways with GMPS: view

UniProtKB/Swiss-Prot P49915-GUAA_HUMAN

  • Pathway: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1

Gene Ontology (GO) - Biological Process for GMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006164 purine nucleotide biosynthetic process --
GO:0006177 GMP biosynthetic process IEA --
GO:0006529 asparagine biosynthetic process --
GO:0006541 glutamine metabolic process IEA --
genes like me logo Genes that share ontologies with GMPS: view

Compounds for GMPS Gene

(12) HMDB Compounds for GMPS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • NH3
  • Amfamox
Guanosine monophosphate
  • 5'-GMP

(2) Drugbank Compounds for GMPS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate

(20) Novoseek inferred chemical compound relationships for GMPS Gene

Compound -log(P) Hits PubMed IDs
prfar 95 1
imidazole glycerol phosphate 92.6 3
decoyinine 90.6 3
xanthosine-5-monophosphate 82.9 4
guanylate 78.1 48
genes like me logo Genes that share compounds with GMPS: view

Transcripts for GMPS Gene

Unigene Clusters for GMPS Gene

Guanine monphosphate synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -

Relevant External Links for GMPS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GMPS Gene

mRNA expression in normal human tissues for GMPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMPS Gene

SOURCE GeneReport for Unigene cluster for GMPS Gene Hs.591314

genes like me logo Genes that share expressions with GMPS: view

Orthologs for GMPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GMPS 36
  • 99.66 (n)
  • 99.86 (a)
  • 100 (a)
(Bos Taurus)
Mammalia GMPS 36
  • 95.23 (n)
  • 98.83 (a)
  • 98 (a)
(Canis familiaris)
Mammalia GMPS 36
  • 94.57 (n)
  • 98.11 (a)
  • 96 (a)
(Mus musculus)
Mammalia Gmps 36
  • 91.58 (n)
  • 97.98 (a)
Gmps 16
Gmps 37
  • 98 (a)
(Monodelphis domestica)
Mammalia GMPS 37
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia GMPS 37
  • 96 (a)
(Rattus norvegicus)
Mammalia Gmps 36
  • 92.02 (n)
  • 97.98 (a)
(Gallus gallus)
Aves GMPS 36
  • 82.83 (n)
  • 94.52 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia GMPS 37
  • 94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11147 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gmps 36
  • 80.23 (n)
  • 92.35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6472 36
(Danio rerio)
Actinopterygii gmps 36
  • 74.18 (n)
  • 86.99 (a)
gmps 37
  • 87 (a)
zgc66002 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010139 36
  • 58.63 (n)
  • 61.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta bur 36
  • 58.23 (n)
  • 59.67 (a)
bur 37
  • 58 (a)
bur 38
  • 58 (a)
(Caenorhabditis elegans)
Secernentea gmps-1 37
  • 46 (a)
M106.4 36
  • 56.05 (n)
  • 54.52 (a)
M106.4 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUA1 37
  • 42 (a)
GUA1 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4241 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3703 37
  • 59 (a)
Species with no ortholog for GMPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPS Gene

Gene Tree for GMPS (if available)
Gene Tree for GMPS (if available)

Paralogs for GMPS Gene Pseudogenes for GMPS Gene

genes like me logo Genes that share paralogs with GMPS: view

No data available for Paralogs for GMPS Gene

Variants for GMPS Gene

Sequence variations from dbSNP and Humsavar for GMPS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs386067 -- 155,873,617(-) CCTAA(C/G)GACAC intron-variant
rs401514 -- 155,874,144(-) CACCC(C/T)TGCCA intron-variant
rs406701 -- 155,874,039(-) agggt(A/G)ggaag intron-variant
rs410042 -- 155,871,632(-) GACGG(A/G)GGCGG intron-variant
rs445758 -- 155,874,878(-) TGTAC(C/T)ACAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMPS Gene

Variant ID Type Subtype PubMed ID
nsv877680 CNV Gain 21882294
nsv877681 CNV Loss 21882294

Relevant External Links for GMPS Gene

HapMap Linkage Disequilibrium report

Disorders for GMPS Gene

(1) OMIM Diseases for GMPS Gene (600358)


  • Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

(1) MalaCards Diseases for GMPS Gene

Search for GMPS Gene in MalaCards »

(1) Novoseek inferred disease relationships for GMPS Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for GMPS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GMPS: view

Publications for GMPS Gene

  1. Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. (PMID: 8089153) Hirst M. … Lou L. (J. Biol. Chem. 1994) 2 3 4 23
  2. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. (PMID: 20659789) Jia P. … Zhao Z. (Schizophr. Res. 2010) 3 49
  3. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. (PMID: 15749019) van der Knaap J.A. … Verrijzer C.P. (Mol. Cell 2005) 3 23
  4. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. (PMID: 19834552) Sarkari F. … Frappier L. (PLoS Pathog. 2009) 3 23
  5. The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. (PMID: 7559506) Nakamura J. … Lou L. (J. Biol. Chem. 1995) 3 23

Products for GMPS Gene

Sources for GMPS Gene

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