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Aliases for GMPR2 Gene

Aliases for GMPR2 Gene

  • Guanosine Monophosphate Reductase 2 2 3 4 5
  • EC 1.7.1.7 4 61
  • Guanosine 5-Monophosphate Oxidoreductase 2 4
  • GMPR 2 4

External Ids for GMPR2 Gene

Previous GeneCards Identifiers for GMPR2 Gene

  • GC00U990486
  • GC14P018488
  • GC14P022691
  • GC14P022692
  • GC14P023771
  • GC14P024701
  • GC14P004816

Summaries for GMPR2 Gene

GeneCards Summary for GMPR2 Gene

GMPR2 (Guanosine Monophosphate Reductase 2) is a Protein Coding gene. Among its related pathways are Purine metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include oxidoreductase activity and GMP reductase activity. An important paralog of this gene is GMPR.

UniProtKB/Swiss-Prot for GMPR2 Gene

  • Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPR2 Gene

Genomics for GMPR2 Gene

Regulatory Elements for GMPR2 Gene

Enhancers for GMPR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GMPR2 on UCSC Golden Path with GeneCards custom track

Promoters for GMPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMPR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GMPR2 Gene

Chromosome:
14
Start:
24,232,422 bp from pter
End:
24,239,242 bp from pter
Size:
6,821 bases
Orientation:
Plus strand

Genomic View for GMPR2 Gene

Genes around GMPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPR2 Gene

Proteins for GMPR2 Gene

  • Protein details for GMPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2T1-GMPR2_HUMAN
    Recommended name:
    GMP reductase 2
    Protein Accession:
    Q9P2T1
    Secondary Accessions:
    • D3DS66
    • Q567T0
    • Q6IAJ8
    • Q86T14

    Protein attributes for GMPR2 Gene

    Size:
    348 amino acids
    Molecular mass:
    37874 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GMPR2 Gene

    Alternative splice isoforms for GMPR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMPR2 Gene

Post-translational modifications for GMPR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GMPR2 Gene

Protein Domains for GMPR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2T1

UniProtKB/Swiss-Prot:

GMPR2_HUMAN :
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Family:
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
genes like me logo Genes that share domains with GMPR2: view

No data available for Gene Families for GMPR2 Gene

Function for GMPR2 Gene

Molecular function for GMPR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NH(3) + NADP(+) = guanosine 5-phosphate + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

Enzyme Numbers (IUBMB) for GMPR2 Gene

Gene Ontology (GO) - Molecular Function for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003920 GMP reductase activity IDA 22037469
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GMPR2: view
genes like me logo Genes that share phenotypes with GMPR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GMPR2

CRISPR Products

miRNA for GMPR2 Gene

miRTarBase miRNAs that target GMPR2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPR2 Gene

Localization for GMPR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GMPR2 Gene COMPARTMENTS Subcellular localization image for GMPR2 gene
Compartment Confidence
cytosol 5
mitochondrion 3
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:1902560 GMP reductase complex IEA --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMPR2 Gene

Pathways & Interactions for GMPR2 Gene

genes like me logo Genes that share pathways with GMPR2: view

Pathways by source for GMPR2 Gene

1 KEGG pathway for GMPR2 Gene

Gene Ontology (GO) - Biological Process for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0043101 purine-containing compound salvage TAS --
GO:0046037 GMP metabolic process IDA 22037469
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for SIGNOR curated interactions for GMPR2 Gene

Drugs & Compounds for GMPR2 Gene

(2) Drugs for GMPR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine monophosphate Experimental Pharma 0
Inosinic acid Experimental Pharma 0

(5) Additional Compounds for GMPR2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with GMPR2: view

Transcripts for GMPR2 Gene

Unigene Clusters for GMPR2 Gene

Guanosine monophosphate reductase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMPR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15:
SP16: - - -
SP17: - - - -
SP18: - -
SP19:

ExUns: 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for GMPR2 Gene

GeneLoc Exon Structure for
GMPR2
ECgene alternative splicing isoforms for
GMPR2

Expression for GMPR2 Gene

mRNA expression in normal human tissues for GMPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMPR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GMPR2 Gene



Protein tissue co-expression partners for GMPR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GMPR2 Gene:

GMPR2

SOURCE GeneReport for Unigene cluster for GMPR2 Gene:

Hs.368855

mRNA Expression by UniProt/SwissProt for GMPR2 Gene:

Q9P2T1-GMPR2_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with GMPR2: view

Primer Products

No data available for mRNA differential expression in normal tissues for GMPR2 Gene

Orthologs for GMPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GMPR2 34
  • 92.1 (n)
  • 95.38 (a)
GMPR2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GMPR2 34
  • 92.58 (n)
  • 97.11 (a)
GMPR2 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gmpr2 34
  • 89.53 (n)
  • 95.39 (a)
Gmpr2 16
Gmpr2 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GMPR2 34
  • 99.71 (n)
  • 99.71 (a)
GMPR2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmpr2 34
  • 91.14 (n)
  • 96.15 (a)
oppossum
(Monodelphis domestica)
Mammalia GMPR2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GMPR2 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves IMPDH2 35
  • 11 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GMPR2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmpr2 34
  • 74.18 (n)
  • 84.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12819 34
zebrafish
(Danio rerio)
Actinopterygii gmpr2 34
  • 73.64 (n)
  • 80.52 (a)
wufb63f02 34
gmpr2 35
  • 80 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F32D1.5 34
  • 64.34 (n)
  • 70.64 (a)
F32D1.5 35
  • 68 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD1 35
  • 16 (a)
ManyToMany
IMD2 35
  • 20 (a)
ManyToMany
IMD3 35
  • 20 (a)
ManyToMany
IMD4 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 35
  • 14 (a)
OneToMany
Species where no ortholog for GMPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPR2 Gene

ENSEMBL:
Gene Tree for GMPR2 (if available)
TreeFam:
Gene Tree for GMPR2 (if available)

Paralogs for GMPR2 Gene

Paralogs for GMPR2 Gene

genes like me logo Genes that share paralogs with GMPR2: view

Variants for GMPR2 Gene

Sequence variations from dbSNP and Humsavar for GMPR2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_049602 -

Variation tolerance for GMPR2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GMPR2 Gene

Disorders for GMPR2 Gene

Relevant External Links for GMPR2

Human Genome Epidemiology (HuGE) Navigator
GMPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMPR2

No disorders were found for GMPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMPR2 Gene

Publications for GMPR2 Gene

  1. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. (PMID: 12669231) Zhang J. … Cao X. (J. Cancer Res. Clin. Oncol. 2003) 3 4 22 65
  2. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. (PMID: 12009299) Deng Y. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 3 4 22 65
  3. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (I^-I+)8 barrel enzymes. (PMID: 22037469) Patton G.C. … Hedstrom L. (Nat. Chem. Biol. 2011) 3 4 65
  4. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP. (PMID: 16359702) Li J. … Mao Y. (J. Mol. Biol. 2006) 4 22 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for GMPR2 Gene

Sources for GMPR2 Gene

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