Aliases for GMPR2 Gene
External Ids for GMPR2 Gene
Previous GeneCards Identifiers for GMPR2 Gene
GeneCards Summary for GMPR2 Gene
GMPR2 (Guanosine Monophosphate Reductase 2) is a Protein Coding gene. Diseases associated with GMPR2 include gastric adenocarcinoma. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include oxidoreductase activity and GMP reductase activity. An important paralog of this gene is IMPDH2.
UniProtKB/Swiss-Prot for GMPR2 Gene
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).