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Aliases for GMPR2 Gene

Aliases for GMPR2 Gene

  • Guanosine Monophosphate Reductase 2 2 3 4 5
  • EC 1.7.1.7 4 58
  • Guanosine 5-Monophosphate Oxidoreductase 2 4
  • GMPR 2 4

External Ids for GMPR2 Gene

Previous GeneCards Identifiers for GMPR2 Gene

  • GC00U990486
  • GC14P018488
  • GC14P022691
  • GC14P022692
  • GC14P023771
  • GC14P024701
  • GC14P004816

Summaries for GMPR2 Gene

Entrez Gene Summary for GMPR2 Gene

  • This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for GMPR2 Gene

GMPR2 (Guanosine Monophosphate Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include oxidoreductase activity and GMP reductase activity. An important paralog of this gene is GMPR.

UniProtKB/Swiss-Prot for GMPR2 Gene

  • Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

Additional gene information for GMPR2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPR2 Gene

Genomics for GMPR2 Gene

Regulatory Elements for GMPR2 Gene

Enhancers for GMPR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H024277 1.4 FANTOM5 Ensembl ENCODE 12.2 +47.2 47179 5 CTCF PKNOX1 NFIB MAX EBF1 RAD21 RELA RFX5 POLR2A EED DHRS1 TINF2 NOP9 LTB4R2 CIDEB LTB4R GMPR2 NEDD8 NEDD8-MDP1 MDP1
GH14H024270 1.5 FANTOM5 ENCODE 11.2 +40.4 40404 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 IPO4 TSSK4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1 TINF2 LTB4R
GH14H024275 0.5 ENCODE 11.2 +43.3 43288 0 CTCF L3MBTL2 ARID4B RAD21 TINF2 NEDD8-MDP1 NEDD8 DHRS1 NOP9 GMPR2 MDP1 ENSG00000254692 CHMP4A TM9SF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GMPR2 on UCSC Golden Path with GeneCards custom track

Promoters for GMPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066843 -22 2001 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for GMPR2 Gene

Chromosome:
14
Start:
24,232,422 bp from pter
End:
24,239,242 bp from pter
Size:
6,821 bases
Orientation:
Plus strand

Genomic View for GMPR2 Gene

Genes around GMPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPR2 Gene

Proteins for GMPR2 Gene

  • Protein details for GMPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2T1-GMPR2_HUMAN
    Recommended name:
    GMP reductase 2
    Protein Accession:
    Q9P2T1
    Secondary Accessions:
    • D3DS66
    • Q567T0
    • Q6IAJ8
    • Q86T14

    Protein attributes for GMPR2 Gene

    Size:
    348 amino acids
    Molecular mass:
    37874 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GMPR2 Gene

    Alternative splice isoforms for GMPR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GMPR2 Gene

Selected DME Specific Peptides for GMPR2 Gene

Q9P2T1:
  • IISDGGC
  • RPKRSTLKSRS
  • ECADAAHGL
  • AGNVVTG
  • KLDFKDVLLRPKRS
  • GSVCTTR
  • GYPQLSA
  • RTTFIRV
  • EELILSGAD
  • GADFVMLGGM
  • TAVHKHY
  • DVANGYSE
  • NMDTVGTF
  • RSTCTYVGA
  • GGVAEYRA
  • KLFYGMSS
  • FRNSKQTYSG
  • PGDVAKAFG

Post-translational modifications for GMPR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GMPR2 Gene

Gene Families for GMPR2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GMPR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2T1

UniProtKB/Swiss-Prot:

GMPR2_HUMAN :
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Family:
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
genes like me logo Genes that share domains with GMPR2: view

Function for GMPR2 Gene

Molecular function for GMPR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NH(3) + NADP(+) = guanosine 5-phosphate + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).

Enzyme Numbers (IUBMB) for GMPR2 Gene

Gene Ontology (GO) - Molecular Function for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003920 GMP reductase activity IEA,IDA 22037469
GO:0003938 IMP dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GMPR2: view
genes like me logo Genes that share phenotypes with GMPR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GMPR2

CRISPR Products

miRNA for GMPR2 Gene

miRTarBase miRNAs that target GMPR2

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPR2 Gene

Localization for GMPR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMPR2 gene
Compartment Confidence
cytosol 5
mitochondrion 3
plasma membrane 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:1902560 GMP reductase complex IEA --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMPR2 Gene

Pathways & Interactions for GMPR2 Gene

genes like me logo Genes that share pathways with GMPR2: view

Pathways by source for GMPR2 Gene

1 KEGG pathway for GMPR2 Gene

Gene Ontology (GO) - Biological Process for GMPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0006163 purine nucleotide metabolic process IEA --
GO:0006164 purine nucleotide biosynthetic process IEA --
GO:0009117 nucleotide metabolic process IEA --
GO:0043101 purine-containing compound salvage TAS --
genes like me logo Genes that share ontologies with GMPR2: view

No data available for SIGNOR curated interactions for GMPR2 Gene

Drugs & Compounds for GMPR2 Gene

(3) Drugs for GMPR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Guanosine monophosphate Experimental Pharma 0
Inosinic acid Experimental Pharma 0

(4) Additional Compounds for GMPR2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with GMPR2: view

Transcripts for GMPR2 Gene

Unigene Clusters for GMPR2 Gene

Guanosine monophosphate reductase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMPR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15:
SP16: - - -
SP17: - - - -
SP18: - -
SP19:

ExUns: 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for GMPR2 Gene

GeneLoc Exon Structure for
GMPR2
ECgene alternative splicing isoforms for
GMPR2

Expression for GMPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GMPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GMPR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GMPR2 Gene



Protein tissue co-expression partners for GMPR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GMPR2 Gene:

GMPR2

SOURCE GeneReport for Unigene cluster for GMPR2 Gene:

Hs.368855

mRNA Expression by UniProt/SwissProt for GMPR2 Gene:

Q9P2T1-GMPR2_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GMPR2 Gene

  • Nervous system(4.7)
  • Blood(4.4)
  • Liver(4.3)
  • Lung(4.3)
  • Skin(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GMPR2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMPR2 Gene

Orthologs for GMPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GMPR2 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia GMPR2 33 34
  • 92.58 (n)
cow
(Bos Taurus)
Mammalia GMPR2 33 34
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia Gmpr2 33
  • 91.14 (n)
mouse
(Mus musculus)
Mammalia Gmpr2 33 16 34
  • 89.53 (n)
oppossum
(Monodelphis domestica)
Mammalia GMPR2 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GMPR2 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves IMPDH2 34
  • 11 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GMPR2 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmpr2 33
  • 74.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12819 33
zebrafish
(Danio rerio)
Actinopterygii gmpr2 33 34
  • 73.64 (n)
wufb63f02 33
worm
(Caenorhabditis elegans)
Secernentea F32D1.5 33 34
  • 64.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD2 34
  • 20 (a)
ManyToMany
IMD3 34
  • 20 (a)
ManyToMany
IMD4 34
  • 19 (a)
ManyToMany
IMD1 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 34
  • 14 (a)
OneToMany
Species where no ortholog for GMPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPR2 Gene

ENSEMBL:
Gene Tree for GMPR2 (if available)
TreeFam:
Gene Tree for GMPR2 (if available)

Paralogs for GMPR2 Gene

Variants for GMPR2 Gene

Sequence variations from dbSNP and Humsavar for GMPR2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs183352266 Likely benign 24,239,706(+) AGGCA(A/G/T)TCCAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs386352308 Uncertain significance 24,238,360(+) GAGTT(C/T)TGAAA nc-transcript-variant, reference, missense
rs1000034305 -- 24,231,642(+) GCAGC(A/G)GTAAC intron-variant, upstream-variant-2KB
rs1000316790 -- 24,231,721(+) AACAC(A/G)CTCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000504150 -- 24,239,597(+) TATGC(A/T)GACCT downstream-variant-500B

Variation tolerance for GMPR2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMPR2 Gene

Human Gene Mutation Database (HGMD)
GMPR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GMPR2 Gene

Disorders for GMPR2 Gene

Relevant External Links for GMPR2

Human Genome Epidemiology (HuGE) Navigator
GMPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMPR2

No disorders were found for GMPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMPR2 Gene

Publications for GMPR2 Gene

  1. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. (PMID: 12669231) Zhang J … Cao X (Journal of cancer research and clinical oncology 2003) 3 4 22 60
  2. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. (PMID: 12009299) Deng Y … Mao Y (The international journal of biochemistry & cell biology 2002) 3 4 22 60
  3. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. (PMID: 22037469) Patton GC … Hedstrom L (Nature chemical biology 2011) 3 4 60
  4. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP. (PMID: 16359702) Li J … Mao Y (Journal of molecular biology 2006) 4 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for GMPR2 Gene

Sources for GMPR2 Gene

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