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Aliases for GMPR Gene

Aliases for GMPR Gene

  • Guanosine Monophosphate Reductase 2 3 5
  • Guanosine 5-Monophosphate Oxidoreductase 1 3 4
  • Guanosine Monophosphate Reductase 1 3 4
  • GMP Reductase 1 2 3
  • EC 1.7.1.7 4 61
  • GMPR 1 3 4
  • GMPR1 3 4
  • Guanine Monophosphate Reductase 3

External Ids for GMPR Gene

Previous GeneCards Identifiers for GMPR Gene

  • GC06P016296
  • GC06P016346
  • GC06P016187

Summaries for GMPR Gene

Entrez Gene Summary for GMPR Gene

  • This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]

GeneCards Summary for GMPR Gene

GMPR (Guanosine Monophosphate Reductase) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Purine metabolism (KEGG). GO annotations related to this gene include GMP reductase activity. An important paralog of this gene is GMPR2.

UniProtKB/Swiss-Prot for GMPR Gene

  • Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPR Gene

Genomics for GMPR Gene

Regulatory Elements for GMPR Gene

Enhancers for GMPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G016204 1.5 Ensembl ENCODE dbSUPER 20.9 -32.6 -32606 2.7 HDGF PKNOX1 ARNT WRNIP1 FEZF1 ZNF2 ZNF143 FOS JUNB ZNF488 GMPR RNU6-1114P PIR38615
GH06G016214 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -23.1 -23065 2.6 PKNOX1 CREB3L1 ARNT SIN3A ZNF766 FOS KLF13 JUNB REST ZNF592 GMPR MYLIP PIR38615 RNU6-1114P
GH06G015689 1.4 Ensembl ENCODE 10.3 -547.6 -547631 2.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B ZNF2 ZNF143 ZNF207 KLF13 DEK MYLIP RNU6-1114P GMPR DTNBP1 PIR51786
GH06G016257 1.3 Ensembl ENCODE dbSUPER 9.4 +19.9 19862 1.7 ESRRA PKNOX1 ARNT SAP30 TAL1 CEBPG FOSL1 POLR2A ZNF600 DNMT1 GMPR ENSG00000282024
GH06G016267 1.3 ENCODE dbSUPER 9.3 +29.4 29394 0.8 HDGF ATF1 PKNOX1 CREB3L1 ARNT SIN3A E2F7 TCF12 ELK1 GATA2 GMPR ENSG00000282024 GC06M016363
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GMPR on UCSC Golden Path with GeneCards custom track

Promoters for GMPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193942 420 1601 HDGF PKNOX1 ARNT GATA2 KLF7 KLF13 KDM4B SP3 JUNB REST

Genomic Location for GMPR Gene

Chromosome:
6
Start:
16,238,580 bp from pter
End:
16,295,549 bp from pter
Size:
56,970 bases
Orientation:
Plus strand

Genomic View for GMPR Gene

Genes around GMPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPR Gene

Proteins for GMPR Gene

  • Protein details for GMPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36959-GMPR1_HUMAN
    Recommended name:
    GMP reductase 1
    Protein Accession:
    P36959
    Secondary Accessions:
    • Q96HQ6

    Protein attributes for GMPR Gene

    Size:
    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GMPR Gene

neXtProt entry for GMPR Gene

Selected DME Specific Peptides for GMPR Gene

P36959:
  • IISDGGC
  • AGNVVTG
  • KLDFKDVLLRPKRS
  • GSVCTTR
  • GYPQLSA
  • EELILSGAD
  • GADFVMLGGM
  • DVANGYSE
  • NMDTVGTF
  • RSTCTYVGA
  • GGVAEYRA
  • KLFYGMSS
  • FRNSKQTYSG
  • PGDVAKAFG
  • DILGGLRS

Post-translational modifications for GMPR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMPR Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GMPR Gene

Protein Domains for GMPR Gene

Suggested Antigen Peptide Sequences for GMPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36959

UniProtKB/Swiss-Prot:

GMPR1_HUMAN :
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Family:
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
genes like me logo Genes that share domains with GMPR: view

No data available for Gene Families for GMPR Gene

Function for GMPR Gene

Molecular function for GMPR Gene

GENATLAS Biochemistry:
guanosine monophosphate reductase
UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NH(3) + NADP(+) = guanosine 5-phosphate + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Enzyme Numbers (IUBMB) for GMPR Gene

Gene Ontology (GO) - Molecular Function for GMPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003920 GMP reductase activity EXP,TAS 218932
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GMPR: view
genes like me logo Genes that share phenotypes with GMPR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GMPR
  • Applied Biological Materials Clones for GMPR

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPR Gene

Localization for GMPR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GMPR gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GMPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:1902560 GMP reductase complex IEA --
genes like me logo Genes that share ontologies with GMPR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GMPR Gene

Pathways & Interactions for GMPR Gene

genes like me logo Genes that share pathways with GMPR: view

Pathways by source for GMPR Gene

1 KEGG pathway for GMPR Gene

Gene Ontology (GO) - Biological Process for GMPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0009117 nucleotide metabolic process IEA --
GO:0009409 response to cold TAS 9813009
GO:0043101 purine-containing compound salvage TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GMPR: view

No data available for SIGNOR curated interactions for GMPR Gene

Drugs & Compounds for GMPR Gene

(2) Drugs for GMPR Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine monophosphate Experimental Pharma Target 0
Inosinic acid Experimental Pharma 0

(5) Additional Compounds for GMPR Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with GMPR: view

Transcripts for GMPR Gene

mRNA/cDNA for GMPR Gene

Unigene Clusters for GMPR Gene

Guanosine monophosphate reductase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GMPR
  • Applied Biological Materials Clones for GMPR

Alternative Splicing Database (ASD) splice patterns (SP) for GMPR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2:
SP3: - -

Relevant External Links for GMPR Gene

GeneLoc Exon Structure for
GMPR
ECgene alternative splicing isoforms for
GMPR

Expression for GMPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GMPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMPR Gene

This gene is overexpressed in Muscle - Skeletal (x11.5), Heart - Left Ventricle (x4.8), and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for GMPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0), Spinal cord (13.4), and Platelet (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GMPR Gene



Protein tissue co-expression partners for GMPR Gene

NURSA nuclear receptor signaling pathways regulating expression of GMPR Gene:

GMPR

SOURCE GeneReport for Unigene cluster for GMPR Gene:

Hs.484741

Evidence on tissue expression from TISSUES for GMPR Gene

  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GMPR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GMPR Gene

Orthologs for GMPR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GMPR 34 35
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia GMPR 34 35
  • 90.43 (n)
dog
(Canis familiaris)
Mammalia GMPR 34 35
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia GMPR 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmpr 34
  • 87.6 (n)
mouse
(Mus musculus)
Mammalia Gmpr 34 16 35
  • 87.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GMPR 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves GMPR 34 35
  • 79.13 (n)
lizard
(Anolis carolinensis)
Reptilia GMPR 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmpr 34
  • 75.65 (n)
Str.7390 34
zebrafish
(Danio rerio)
Actinopterygii gmpr 34 35
  • 74.88 (n)
worm
(Caenorhabditis elegans)
Secernentea F32D1.5 36 35
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD2 35
  • 20 (a)
ManyToMany
IMD3 35
  • 19 (a)
ManyToMany
IMD4 35
  • 19 (a)
ManyToMany
IMD1 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 35
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2163 34
Species where no ortholog for GMPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPR Gene

ENSEMBL:
Gene Tree for GMPR (if available)
TreeFam:
Gene Tree for GMPR (if available)

Paralogs for GMPR Gene

Paralogs for GMPR Gene

(1) SIMAP similar genes for GMPR Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GMPR Gene

genes like me logo Genes that share paralogs with GMPR: view

Variants for GMPR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GMPR Gene

GMPR1_HUMAN-P36959
At least two different alleles are known.

Sequence variations from dbSNP and Humsavar for GMPR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1042391 Benign 16,290,530(+) AAGTG(A/T)TTGAG reference, missense, stop-gained
rs1000010469 -- 16,266,499(+) ACGTG(C/G/T)CACCT intron-variant
rs1000040631 -- 16,245,920(+) ACTAC(C/T)CTGAC intron-variant
rs1000062849 -- 16,266,299(+) GTGTA(A/G)ACCAT intron-variant
rs1000170012 -- 16,274,304(+) CCCCA(G/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GMPR Gene

Variant ID Type Subtype PubMed ID
dgv989e201 CNV deletion 23290073
esv2167446 CNV deletion 18987734
esv2731621 CNV deletion 23290073
esv2731622 CNV deletion 23290073
esv3567319 CNV deletion 23714750
esv3608192 CNV loss 21293372
esv3608193 CNV gain 21293372
nsv1137067 CNV deletion 24896259
nsv521185 CNV loss 19592680
nsv521653 CNV loss 19592680

Variation tolerance for GMPR Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMPR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GMPR

Disorders for GMPR Gene

Relevant External Links for GMPR

Genetic Association Database (GAD)
GMPR
Human Genome Epidemiology (HuGE) Navigator
GMPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMPR

No disorders were found for GMPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMPR Gene

Publications for GMPR Gene

  1. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth D.M. … Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 46 64
  2. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 46 64
  3. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP. (PMID: 16359702) Li J. … Mao Y. (J. Mol. Biol. 2006) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for GMPR Gene

  • Addgene plasmids for GMPR

Sources for GMPR Gene

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