Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GMPR Gene

Aliases for GMPR Gene

  • Guanosine Monophosphate Reductase 2 3 5
  • Guanosine 5-Monophosphate Oxidoreductase 1 3 4
  • Guanosine Monophosphate Reductase 1 3 4
  • EC 1.7.1.7 4 63
  • GMPR 1 3 4
  • GMPR1 3 4
  • Guanine Monophosphate Reductase 3

External Ids for GMPR Gene

Previous GeneCards Identifiers for GMPR Gene

  • GC06P016296
  • GC06P016346
  • GC06P016187

Summaries for GMPR Gene

Entrez Gene Summary for GMPR Gene

  • This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]

GeneCards Summary for GMPR Gene

GMPR (Guanosine Monophosphate Reductase) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include GMP reductase activity. An important paralog of this gene is IMPDH2.

UniProtKB/Swiss-Prot for GMPR Gene

  • Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMPR Gene

Genomics for GMPR Gene

Regulatory Elements for GMPR Gene

Promoters for GMPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMPR on UCSC Golden Path with GeneCards custom track

Genomic Location for GMPR Gene

Chromosome:
6
Start:
16,238,580 bp from pter
End:
16,295,549 bp from pter
Size:
56,970 bases
Orientation:
Plus strand

Genomic View for GMPR Gene

Genes around GMPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMPR Gene

Proteins for GMPR Gene

  • Protein details for GMPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36959-GMPR1_HUMAN
    Recommended name:
    GMP reductase 1
    Protein Accession:
    P36959
    Secondary Accessions:
    • Q96HQ6

    Protein attributes for GMPR Gene

    Size:
    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GMPR Gene

neXtProt entry for GMPR Gene

Proteomics data for GMPR Gene at MOPED

Post-translational modifications for GMPR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GMPR Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GMPR Gene

Protein Domains for GMPR Gene

Suggested Antigen Peptide Sequences for GMPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36959

UniProtKB/Swiss-Prot:

GMPR1_HUMAN :
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Family:
  • Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
genes like me logo Genes that share domains with GMPR: view

No data available for Gene Families for GMPR Gene

Function for GMPR Gene

Molecular function for GMPR Gene

GENATLAS Biochemistry:
guanosine monophosphate reductase
UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NH(3) + NADP(+) = guanosine 5-phosphate + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Enzyme Numbers (IUBMB) for GMPR Gene

genes like me logo Genes that share phenotypes with GMPR: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMPR Gene

Localization for GMPR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GMPR Gene COMPARTMENTS Subcellular localization image for GMPR gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GMPR Gene

Pathways & Interactions for GMPR Gene

genes like me logo Genes that share pathways with GMPR: view

Pathways by source for GMPR Gene

1 KEGG pathway for GMPR Gene

Interacting Proteins for GMPR Gene

Gene Ontology (GO) - Biological Process for GMPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA,TAS --
GO:0006163 purine nucleotide metabolic process IEA --
GO:0009117 nucleotide metabolic process IEA --
GO:0055086 nucleobase-containing small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GMPR: view

No data available for SIGNOR curated interactions for GMPR Gene

Drugs & Compounds for GMPR Gene

(2) Drugs for GMPR Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine monophosphate Experimental Pharma Target 0
Inosinic acid Experimental Pharma 0

(5) Additional Compounds for GMPR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with GMPR: view

Transcripts for GMPR Gene

mRNA/cDNA for GMPR Gene

Unigene Clusters for GMPR Gene

Guanosine monophosphate reductase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GMPR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2:
SP3: - -

Relevant External Links for GMPR Gene

GeneLoc Exon Structure for
GMPR
ECgene alternative splicing isoforms for
GMPR

Expression for GMPR Gene

mRNA expression in normal human tissues for GMPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMPR Gene

This gene is overexpressed in Muscle - Skeletal (x11.5), Heart - Left Ventricle (x4.8), and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for GMPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0), Spinal cord (13.4), and Platelet (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMPR Gene



SOURCE GeneReport for Unigene cluster for GMPR Gene Hs.484741

genes like me logo Genes that share expression patterns with GMPR: view

Protein tissue co-expression partners for GMPR Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GMPR Gene

Orthologs for GMPR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GMPR 35
  • 90.43 (n)
  • 95.36 (a)
GMPR 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GMPR 35
  • 89.28 (n)
  • 95.36 (a)
GMPR 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gmpr 35
  • 87.4 (n)
  • 95.64 (a)
Gmpr 16
Gmpr 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GMPR 35
  • 99.13 (n)
  • 99.71 (a)
GMPR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gmpr 35
  • 87.6 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia GMPR 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GMPR 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves GMPR 35
  • 79.13 (n)
  • 86.96 (a)
GMPR 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GMPR 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gmpr 35
  • 75.65 (n)
  • 83.48 (a)
Str.7390 35
zebrafish
(Danio rerio)
Actinopterygii gmpr 35
  • 74.88 (n)
  • 83.48 (a)
gmpr 36
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F32D1.5 37
  • 69 (a)
F32D1.5 36
  • 67 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD1 36
  • 17 (a)
ManyToMany
IMD2 36
  • 20 (a)
ManyToMany
IMD3 36
  • 19 (a)
ManyToMany
IMD4 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2163 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 36
  • 14 (a)
OneToMany
Species with no ortholog for GMPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMPR Gene

ENSEMBL:
Gene Tree for GMPR (if available)
TreeFam:
Gene Tree for GMPR (if available)

Paralogs for GMPR Gene

Paralogs for GMPR Gene

(1) SIMAP similar genes for GMPR Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GMPR Gene

genes like me logo Genes that share paralogs with GMPR: view

Variants for GMPR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GMPR Gene

P36959-GMPR1_HUMAN
At least two different alleles are known.

Sequence variations from dbSNP and Humsavar for GMPR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_003969 -
rs1042391 - 16,290,530(+) AAGTG(A/T)TTGAG reference, missense, stop-gained
rs676 -- 16,238,735(+) AAGGA(C/T)GTCCT reference, synonymous-codon
rs6723 -- 16,295,358(+) GCCTT(C/G)TCGGG utr-variant-3-prime
rs12398 -- 16,295,285(+) GCTCC(A/T)GAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GMPR Gene

Variant ID Type Subtype PubMed ID
nsv521185 CNV Loss 19592680
esv2731621 CNV Deletion 23290073
esv2167446 CNV Deletion 18987734
dgv1036e201 CNV Deletion 23290073
esv2731622 CNV Deletion 23290073
nsv521653 CNV Loss 19592680

Variation tolerance for GMPR Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMPR Gene

HapMap Linkage Disequilibrium report
GMPR

Disorders for GMPR Gene

Relevant External Links for GMPR

Genetic Association Database (GAD)
GMPR
Human Genome Epidemiology (HuGE) Navigator
GMPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GMPR

No disorders were found for GMPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMPR Gene

Publications for GMPR Gene

  1. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth D.M. … Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 48 67
  2. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP. (PMID: 16359702) Li J. … Mao Y. (J. Mol. Biol. 2006) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. (PMID: 12009299) Deng Y. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 3 23

Products for GMPR Gene

Sources for GMPR Gene

Back to Top

Content