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GMNN Gene

protein-coding   GIFtS: 63
GCID: GC06P024779

Geminin, DNA Replication Inhibitor

  See GMNN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Geminin, DNA Replication Inhibitor1 2
Gem2
geminin2

External Ids:    HGNC: 174931   Entrez Gene: 510532   Ensembl: ENSG000001123127   OMIM: 6028425   UniProtKB: O754963   

Export aliases for GMNN gene to outside databases

Previous GC identifers: GC06P024832 GC06P024883 GC06P024778 GC06P024725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GMNN Gene:
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA
replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance
proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the
cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased
expression of this gene may play a role in several malignancies including colon, rectal and breast cancer.
Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are
located on the short arm of chromosome 16. (provided by RefSeq, Oct 2011)

GeneCards Summary for GMNN Gene:
GMNN (geminin, DNA replication inhibitor) is a protein-coding gene. Diseases associated with GMNN include melanoacanthoma, and breast cancer. GO annotations related to this gene include repressing transcription factor binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: GEMI_HUMAN, O75496
Function: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex
(pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase
transition permits replication in the succeeding cell cycle
Function: Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative
control

Gene Wiki entry for GMNN (Geminin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GMNN gene promoter:
         AhR   Sox5   p53   FOXD3   HNF-3beta   PPAR-gamma1   FOXJ2 (long isoform)   Msx-1   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGMNN promoter sequence
   Search Chromatin IP Primers for GMNN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GMNN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p21.32

GMNN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GMNN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P024779:  view genomic region     (about GC identifiers)

Start:
24,775,159 bp from pter      End:
24,786,327 bp from pter
Size:
11,169 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GEMI_HUMAN, O75496 (See protein sequence)
Recommended Name: Geminin  
Size: 209 amino acids; 23565 Da
Subunit: Homotetramer. Interacts with CDT1; this inhibits binding of the MCM complex to origins of replication.
The complex with CDT1 exists in two forms, a "permissive" heterotrimer and an "inhibitory" heterohexamer.
Interacts (via coiled-coil domain) with IDAS (via coiled-coil domain); this targets GMNN to the nucleus. The
heterodimer formed by GMNN and MCIDAS has much lower affinity for CDT1 than the GMNN homodimer. Interacts with a
subset of Hox proteins, affinity increasing from anterior to posterior types, the strongest interaction being
with HOXB1, HOXC9 and HOXD10. Interacts with LRWD1 from G1/S to mitosis
Developmental stage: Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of
the metaphase-anaphase transition
Sequence caution: Sequence=CAC21511.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
5 PDB 3D structures from and Proteopedia for GMNN:
1T6F (3D)        1UII (3D)        2LP0 (3D)        2WVR (3D)        4BRY (3D)    
Secondary accessions: B3KMM8 Q9H1Z1

Explore the universe of human proteins at neXtProt for GMNN: NX_O75496

Explore proteomics data for GMNN at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and
    more potent inhibitory effect on Hox transcriptional activity1
  • Ubiquitination2 at Lys50
  • Modification sites at PhosphoSitePlus

  • See GMNN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001238918.1  NP_001238919.1  NP_001238920.1  NP_056979.1  

    ENSEMBL proteins: 
     ENSP00000348902   ENSP00000230056   ENSP00000367293   ENSP00000419584   ENSP00000367298  
    Reactome Protein details: O75496

    GMNN Human Recombinant Protein Products:

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    Novus Biologicals GMNN Proteins
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    antibodies-online proteins for GMNN (19 products) 

     
    antibodies-online peptides for GMNN

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022786 Geminin_fam

    Graphical View of Domain Structure for InterPro Entry O75496

    ProtoNet protein and cluster: O75496

    UniProtKB/Swiss-Prot: GEMI_HUMAN, O75496
    Similarity: Belongs to the geminin family


    Find genes that share domains with GMNN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GEMI_HUMAN, O75496
    Function: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex
    (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase
    transition permits replication in the succeeding cell cycle
    Function: Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative
    control

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI11125146
    GO:0042826histone deacetylase binding IPI16924111
    GO:0070491repressing transcription factor binding IEA--
         
    Find genes that share ontologies with GMNN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GMNN:
     Decreased TP53 protein express  Increased circadian rhythm amp 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gmnn):
     behavior/neurological  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  normal  reproductive system 
     vision/eye 

    Find genes that share phenotypes with GMNN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GMNN: Gmnntm1.1Kio Gmnntm1.2Kio Gmnntm1Nyma

       genOway: Develop your customized and physiologically relevant rodent model for GMNN

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    miRTarBase miRNAs that target GMNN:
    hsa-mir-193b-3p (MIRT016570), hsa-mir-449b-5p (MIRT006352), hsa-mir-449a (MIRT006345), hsa-mir-324-5p (MIRT043150), hsa-mir-26b-5p (MIRT029967)

    Block miRNA regulation of human, mouse, rat GMNN using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GMNN:
    hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidGMNN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GMNN (NM_015895)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GEMI_HUMAN, O75496: Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GMNN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GMNN About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    DNA Replication0.66
    Cell cycle Start of DNA replication in early S phase0.53
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of DNA replication0.93
    Removal of licensing factors from origins0.86
    DNA Replication0.92
    M/G1 Transition0.81
    Assembly of the pre-replicative complex0.89
    DNA Replication Pre-Initiation0.81
    CDT1 association with the CDC6-ORC-origin complex0.87
    Association of licensing factors with the pre-replicative complex0.00
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    5Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with GMNN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for GMNN
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for GMNN
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Start of DNA replication in early S phase

    1 BioSystems Pathway for GMNN
        DNA Replication


    3 Reactome Pathways for GMNN
        CDT1 association with the CDC6:ORC:origin complex
    Removal of licensing factors from origins
    Association of licensing factors with the pre-replicative complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GMNN
    Interactions:

        GeneGlobe Interaction Network for GMNN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GMNN (O754961, 2, 3 ENSP000002300564) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427712, 3, ENSP000003551534MINT-50444 I2D: score=3 STRING: ENSP00000355153
    CDT1Q9H2111, 2, 3, ENSP000003010194EBI-371669,EBI-456953 MINT-1955603 MINT-4508837 MINT-50424 MINT-4508819 I2D: score=7 STRING: ENSP00000301019
    CDKN1AP389362, 3, ENSP000002447414MINT-50445 I2D: score=4 STRING: ENSP00000244741
    MCM6Q145662, 3, ENSP000002641564MINT-50443 I2D: score=4 STRING: ENSP00000264156
    HOXA11P312703, ENSP000000060154I2D: score=4 STRING: ENSP00000006015
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006275regulation of DNA replication ----
    GO:0006461protein complex assembly IEA--
    GO:0008156negative regulation of DNA replication IDA9635433
    GO:0009887organ morphogenesis IEA--

    Find genes that share ontologies with GMNN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GMNN (GEMI)

    1 Novoseek inferred chemical compound relationship for GMNN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0 5 18798731 (1), 16428461 (1)



    Find genes that share compounds with GMNN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GMNN gene (4 alternative transcripts): 
    NM_001251989.1  NM_001251990.1  NM_001251991.1  NM_015895.4  

    Unigene Cluster for GMNN:

    Geminin, DNA replication inhibitor
    Hs.234896  [show with all ESTs]
    Unigene Representative Sequence: BQ064691
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356509(uc021ymn.1 uc003nem.3) ENST00000230056(uc003nen.3 uc021ymo.1)
    ENST00000468943 ENST00000378054 ENST00000476555 ENST00000378059
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate GMNN:
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    SwitchGear 3'UTR luciferase reporter plasmidGMNN 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GMNN

    Additional mRNA sequence: 

    AF067855.1 AK021685.1 AK222992.1 AK315743.1 BC005185.1 BC005389.1 

    8 DOTS entries:

    DT.40253329  DT.92441296  DT.91666495  DT.92441301  DT.100646958  DT.121402585  DT.95165239  DT.99957264 

    Selected AceView cDNA sequences (see all 188):

    CB129671 CR597438 AA614412 CR617635 AK021685 BU629613 CA442918 AA447810 
    AI084586 CD366250 AA447662 CA503202 CR609155 CD367234 BI861855 BC005185 
    AA857702 BM669421 CR615209 BP870823 BQ772723 CN483029 BM699599 AI242828 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GMNN (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:                          -     -     -     -     -                                                                                 
    SP2:                                -     -     -     -                                                                                 
    SP3:                                            -     -                                                                                 
    SP4:                                -     -     -     -                 -                                                               
    SP5:                    -     -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for GMNN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GMNN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTATGTTT
    GMNN Expression
    About this image


    GMNN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
    GMNN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GMNN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234896
        Custom PCR Arrays for GMNN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GMNN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GMNN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gmnn1 , 5 geminin1, 5 83.25(n)1
    79.02(a)1
      13 (10.64 cM)5
    574411  NM_020567.21  NP_065592.11 
     247518455 
    chicken
    (Gallus gallus)
    Aves GMNN1 geminin, DNA replication inhibitor 66.46(n)
    61.01(a)
      421004  NM_001031010.1  NP_001026181.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    42(a)
    many → 1
    many → 1
    4(30783733-30785070)
    4(53910205-53922889)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4612 Xenopus laevis geminin H mRNA, complete cds 78.8(n)    AF067856.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gmnn1 geminin, DNA replication inhibitor 56.46(n)
    51.87(a)
      368320  NM_200086.1  NP_956380.1 


    ENSEMBL Gene Tree for GMNN (if available)
    TreeFam Gene Tree for GMNN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GMNN gene

    Find genes that share paralogs with GMNN           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GMNN
    PGOHUM00000248741 PGOHUM00000248999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GMNN (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819781851,2
    --24695108(+) GCCACC/TATGCC 3 -- us2k10--------
    rs783807261,2
    C,F--24695261(+) TTGCTG/AAAATT 3 -- us2k13Minor allele frequency- A:0.29WA 122
    rs1847824111,2
    --24695326(+) TTTTTA/GAATTA 3 -- us2k10--------
    rs766995911,2
    C,F--24695348(+) ATTTTA/GTTATT 3 -- us2k13Minor allele frequency- G:0.25WA 122
    rs1114015771,2
    C,F--24695364(+) GGTGCG/AGTGGT 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs768000891,2
    C,F--24695549(+) AGAATT/CGCTTG 4 -- us2k12Minor allele frequency- C:0.25WA 4
    rs1883311991,2
    --24695631(+) GACTCC/TGTCTC 4 -- us2k10--------
    rs1995973311,2
    C--24695636(+) CGTCT-/AAAAAA 4 -- us2k10--------
    rs1806882981,2
    --24695785(+) ACTGGA/GGATGA 4 -- us2k10--------
    rs27547741,2
    F--24695801(+) ccctgC/Tggaag 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for GMNN (24775159 - 24786327 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GMNN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5227CNV Loss18451855
    nsv508396CNV Loss20534489
    nsv830609CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GMNN
    DNA2.0 Custom Variant and Variant Library Synthesis for GMNN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602842    OMIM disorders: --

    2 diseases for GMNN:    
    About MalaCards
    melanoacanthoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for GMNN:
    Melanoacanthoma

    Find genes that share disorders with GMNN           About GenesLikeMe

    7 Novoseek inferred disease relationships for GMNN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 32.6 25 19487297 (4), 15291814 (2), 15389519 (2), 18508524 (2) (see all 15)
    oligodendroglioma 27.6 1 15199392 (1)
    tumors 3.68 23 17262828 (3), 15389519 (3), 17947481 (3), 17145831 (2) (see all 12)
    colon cancer 0 3 16273206 (2), 14712211 (1)
    breast cancer 0 10 15376260 (4), 15389519 (3), 16278669 (2), 16919268 (1)
    metastasis 0 1 15376260 (1)
    lymphoma 0 1 15682442 (1)

    Genetic Association Database (GAD): GMNN
    Human Genome Epidemiology (HuGE) Navigator: GMNN (6 documents)

    Export disorders for GMNN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GMNN gene, integrated from 10 sources (see all 184):
    (articles sorted by number of sources associating them with GMNN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Geminin, an inhibitor of DNA replication, is degraded during mitosis. (PubMed id 9635433)1, 2, 3, 9 McGarry T.J. and Kirschner M.W. (Cell 1998)
    2. Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation. (PubMed id 15313623)1, 2, 9 Thepaut M.... Padilla A. (J. Mol. Biol. 2004)
    3. A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. (PubMed id 15260975)1, 2, 9 Saxena S.... Dutta A. (Mol. Cell 2004)
    4. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PubMed id 14993212)1, 2, 9 Sugimoto N.... Fujita M. (J. Biol. Chem. 2004)
    5. Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. (PubMed id 19906994)1, 2, 9 De Marco V....Perrakis A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. (PubMed id 24064211)1, 2 Caillat C.... Perrakis A. (J. Biol. Chem. 2013)
    7. Structural basis for homeodomain recognition by the cell-cycle regulator Geminin. (PubMed id 22615398)1, 2 Zhou B.... Zhu G. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. (PubMed id 21543332)1, 2 Pefani D.E.... Lygerou Z. (J. Biol. Chem. 2011)
    9. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51053 HGNC: 17493 AceView: GMNN Ensembl:ENSG00000112312 euGenes: HUgn51053
    ECgene: GMNN H-InvDB: GMNN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GMNN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GMNN gene:
    Search GeneIP for patents involving GMNN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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