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Aliases for GMIP Gene

Aliases for GMIP Gene

  • GEM Interacting Protein 2 3 5
  • ARHGAP46 3

External Ids for GMIP Gene

Previous GeneCards Identifiers for GMIP Gene

  • GC19M020131
  • GC19M019585
  • GC19M019602
  • GC19M019603
  • GC19M019604
  • GC19M019740
  • GC19M019302

Summaries for GMIP Gene

Entrez Gene Summary for GMIP Gene

  • This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for GMIP Gene

GMIP (GEM Interacting Protein) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ABR.

UniProtKB/Swiss-Prot for GMIP Gene

  • Stimulates, in vitro and in vivo, the GTPase activity of RhoA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GMIP Gene

Genomics for GMIP Gene

Regulatory Elements for GMIP Gene

Enhancers for GMIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GMIP on UCSC Golden Path with GeneCards custom track

Promoters for GMIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GMIP on UCSC Golden Path with GeneCards custom track

Genomic Location for GMIP Gene

19,629,473 bp from pter
19,643,667 bp from pter
14,195 bases
Minus strand

Genomic View for GMIP Gene

Genes around GMIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GMIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GMIP Gene

Proteins for GMIP Gene

  • Protein details for GMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GEM-interacting protein
    Protein Accession:
    Secondary Accessions:
    • A0AVN9
    • B7ZLZ0

    Protein attributes for GMIP Gene

    970 amino acids
    Molecular mass:
    106683 Da
    Quaternary structure:
    • Interacts with GEM through its N-terminal.

    Three dimensional structures from OCA and Proteopedia for GMIP Gene

    Alternative splice isoforms for GMIP Gene


neXtProt entry for GMIP Gene

Proteomics data for GMIP Gene at MOPED

Post-translational modifications for GMIP Gene

  • Ubiquitination at Lys 624 and Lys 672
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GMIP Gene

Domains & Families for GMIP Gene

Gene Families for GMIP Gene

Protein Domains for GMIP Gene

Suggested Antigen Peptide Sequences for GMIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-BAR domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
  • Contains 1 F-BAR domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with GMIP: view

Function for GMIP Gene

Molecular function for GMIP Gene

UniProtKB/Swiss-Prot Function:
Stimulates, in vitro and in vivo, the GTPase activity of RhoA.

Gene Ontology (GO) - Molecular Function for GMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,TAS --
genes like me logo Genes that share ontologies with GMIP: view
genes like me logo Genes that share phenotypes with GMIP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GMIP Gene

Localization for GMIP Gene

Subcellular locations from

Jensen Localization Image for GMIP Gene COMPARTMENTS Subcellular localization image for GMIP gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GMIP Gene

Pathways & Interactions for GMIP Gene

genes like me logo Genes that share pathways with GMIP: view

Pathways by source for GMIP Gene

Gene Ontology (GO) - Biological Process for GMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with GMIP: view

No data available for SIGNOR curated interactions for GMIP Gene

Drugs & Compounds for GMIP Gene

(4) Additional Compounds for GMIP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with GMIP: view

Transcripts for GMIP Gene

Unigene Clusters for GMIP Gene

GEM interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GMIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP4: -

Relevant External Links for GMIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GMIP Gene

mRNA expression in normal human tissues for GMIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GMIP Gene

This gene is overexpressed in Whole Blood (x25.5) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for GMIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Lavage (11.9), Lymph node (10.7), and Monocytes (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GMIP Gene

SOURCE GeneReport for Unigene cluster for GMIP Gene Hs.49427

genes like me logo Genes that share expression patterns with GMIP: view

Protein tissue co-expression partners for GMIP Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GMIP Gene

Orthologs for GMIP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GMIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GMIP 35
  • 85.8 (n)
  • 84.56 (a)
  • 85 (a)
(Canis familiaris)
Mammalia GMIP 35
  • 87.25 (n)
  • 88.62 (a)
  • 88 (a)
(Mus musculus)
Mammalia Gmip 35
  • 82.88 (n)
  • 82.47 (a)
Gmip 16
Gmip 36
  • 82 (a)
(Pan troglodytes)
Mammalia GMIP 35
  • 99.48 (n)
  • 99.48 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gmip 35
  • 82.43 (n)
  • 81.43 (a)
(Monodelphis domestica)
Mammalia GMIP 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia GMIP 36
  • 54 (a)
(Gallus gallus)
Aves GMIP 35
  • 58.81 (n)
  • 51.9 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia GMIP 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gmip 35
  • 54.63 (n)
  • 48.78 (a)
(Danio rerio)
Actinopterygii LOC565801 35
  • 53.12 (n)
  • 44.15 (a)
gmip 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea spv-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 36
  • 13 (a)
RGA2 36
  • 13 (a)
BAG7 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for GMIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GMIP Gene

Gene Tree for GMIP (if available)
Gene Tree for GMIP (if available)

Paralogs for GMIP Gene

Paralogs for GMIP Gene

(5) SIMAP similar genes for GMIP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GMIP: view

Variants for GMIP Gene

Sequence variations from dbSNP and Humsavar for GMIP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12003 - 19,634,670(+) GGCGT(C/G/T)GTAGA reference, missense
rs7257247 -- 19,644,408(+) ATTGA(A/G)AGGAA upstream-variant-2KB
rs62134460 -- 19,639,046(+) CTGCA(C/T)TCCAG intron-variant
rs62137823 -- 19,636,150(+) AGTGA(G/T)CCAAG intron-variant
rs73004988 -- 19,633,805(+) TACCT(C/T)GGTAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GMIP Gene

Variant ID Type Subtype PubMed ID
nsv509725 CNV Insertion 20534489
nsv911309 CNV Loss 21882294
nsv911310 CNV Loss 21882294

Variation tolerance for GMIP Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GMIP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GMIP Gene

Disorders for GMIP Gene

Relevant External Links for GMIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GMIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GMIP Gene

Publications for GMIP Gene

  1. The Gem interacting protein (GMIP) gene is associated with major depressive disorder. (PMID: 16086184) Tadokoro K. … Kunugi H. (Neurogenetics 2005) 2 3 23 48 67
  2. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. (PMID: 12093360) Aresta S. … de Gunzburg J. (Biochem. J. 2002) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis. (PMID: 25173885) Andrieu G. … Hatzoglou A. (Carcinogenesis 2014) 3

Products for GMIP Gene

Sources for GMIP Gene