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GMIP Gene

protein-coding   GIFtS: 57
GCID: GC19M019740

GEM Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GEM Interacting Protein1 2
ARHGAP462
GEM-Interacting Protein2

External Ids:    HGNC: 248521   Entrez Gene: 512912   Ensembl: ENSG000000896397   OMIM: 6096945   UniProtKB: Q9P1073   

Export aliases for GMIP gene to outside databases

Previous GC identifers: GC19M020131 GC19M019585 GC19M019602 GC19M019603 GC19M019604 GC19M019302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GMIP Gene:
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded
protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with
RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for GMIP Gene:
GMIP (GEM interacting protein) is a protein-coding gene. GO annotations related to this gene include Rho GTPase activator activity. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot: GMIP_HUMAN, Q9P107
Function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GMIP gene promoter:
         Pax-5   p53   Olf-1   Lmo2   Roaz   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGMIP promoter sequence
   Search Chromatin IP Primers for GMIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GMIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

GMIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GMIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019740:  view genomic region     (about GC identifiers)

Start:
19,740,285 bp from pter      End:
19,754,476 bp from pter
Size:
14,192 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GMIP_HUMAN, Q9P107 (See protein sequence)
Recommended Name: GEM-interacting protein  
Size: 970 amino acids; 106683 Da
Subunit: Interacts with GEM through its N-terminal
1 PDB 3D structure from and Proteopedia for GMIP:
3QWE (3D)    
Secondary accessions: A0AVN9

Explore the universe of human proteins at neXtProt for GMIP: NX_Q9P107

Explore proteomics data for GMIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys624, Lys672
  • Modification sites at PhosphoSitePlus

  • See GMIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275927.1  NP_001275928.1  NP_057657.2  

    ENSEMBL proteins: 
     ENSP00000203556   ENSP00000467054   ENSP00000465108   ENSP00000468662   ENSP00000466045  
     ENSP00000467946   ENSP00000397075  
    Reactome Protein details: Q9P107

    GMIP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GMIP

     
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    Abcam antibodies for GMIP
    Cloud-Clone Corp. Antibodies for GMIP
    Search ThermoFisher Antibodies for GMIP
    LSBio Antibodies in human, mouse, rat for GMIP

    GMIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GMIP
    Cloud-Clone Corp. CLIAs for GMIP
    Search eBioscience for ELISAs for GMIP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9P107

    ProtoNet protein and cluster: Q9P107

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: GMIP_HUMAN, Q9P107
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with GMIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GMIP_HUMAN, Q9P107
    Function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity IDA12093360
    GO:0005515protein binding IPI12093360
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with GMIP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GMIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GMIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GMIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GMIP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GMIP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GMIP:
    hsa-miR-562 hsa-miR-548p hsa-miR-125a-5p hsa-miR-650 hsa-miR-504 hsa-miR-125b hsa-miR-3612 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidGMIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GMIP
    Predesigned siRNA for gene silencing in human, mouse, rat GMIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GMIP

    Clone
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    OriGene clones in human, mouse for GMIP (see all 7)
    OriGene ORF clones in mouse, rat for GMIP
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    GenScript: all cDNA clones in your preferred vector: GMIP (NM_016573)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GMIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GMIP
    Addgene plasmids for GMIP 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GMIP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GMIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC12093360
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GMIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GMIP About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with GMIP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GMIP
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GMIP
    Interactions:

        GeneGlobe Interaction Network for GMIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GMIP (Q9P1073 ENSP000002035564) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    GEMP550403, ENSP000002975964I2D: score=2 STRING: ENSP00000297596
    ARHGEF38ENSP000002651544STRING: ENSP00000416125 STRING: ENSP00000265154
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032321positive regulation of Rho GTPase activity IDA12093360
    GO:0034259negative regulation of Rho GTPase activity IDA12093360
    GO:0035556intracellular signal transduction IDA12093360

    Find genes that share ontologies with GMIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GMIP

    Selected HMDB Compounds for GMIP (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GMIP gene (3 alternative transcripts): 
    NM_001288998.1  NM_001288999.1  NM_016573.3  

    Unigene Cluster for GMIP:

    GEM interacting protein
    Hs.49427  [show with all ESTs]
    Unigene Representative Sequence: NM_016573
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000203556(uc002nnd.3 uc010xrb.2 uc010xrc.2) ENST00000587238
    ENST00000586269 ENST00000587713 ENST00000593186 ENST00000588171 ENST00000591047
    ENST00000587205 ENST00000445806
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GMIP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GMIP:
    hsa-miR-562 hsa-miR-548p hsa-miR-125a-5p hsa-miR-650 hsa-miR-504 hsa-miR-125b hsa-miR-3612 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidGMIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GMIP
    Predesigned siRNA for gene silencing in human, mouse, rat GMIP
    Clone
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    OriGene clones in human, mouse for GMIP (see all 7)
    OriGene ORF clones in mouse, rat for GMIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GMIP (NM_016573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GMIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GMIP
    Addgene plasmids for GMIP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GMIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GMIP
      QuantiTect SYBR Green Assays in human, mouse, rat GMIP
      QuantiFast Probe-based Assays in human, mouse, rat GMIP

    Additional mRNA sequence: 

    AF086104.1 AF132541.1 AK297220.1 BC032057.1 BC126436.1 BC144142.1 

    8 DOTS entries:

    DT.109981  DT.100778591  DT.95174766  DT.121492657  DT.97821350  DT.100778590  DT.121492574  DT.100743949 

    Selected AceView cDNA sequences (see all 150):

    BX441041 AI202027 AI078685 BC032057 AI356366 BX384312 BM919964 AI498915 
    BG122350 BF222132 CR595802 AI914467 BX406700 AW408617 BX362896 AI348210 
    BM724067 BE674903 AF086104 AL534214 AI400341 AI797837 AI073975 AI818800 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GMIP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                                                
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                      -                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for GMIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GMIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTGGTGC
    GMIP Expression
    About this image


    GMIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    GMIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GMIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49427
        Custom PCR Arrays for GMIP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GMIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GMIP
    QuantiTect SYBR Green Assays in human, mouse, rat GMIP
    QuantiFast Probe-based Assays in human, mouse, rat GMIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GMIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GMIP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gmip1 , 5 Gem-interacting protein1, 5 82.88(n)1
    82.47(a)1
      8 (33.88 cM)5
    788161  NM_198101.11  NP_932769.11 
     698086795 
    chicken
    (Gallus gallus)
    Aves GMIP1 GEM interacting protein 58.81(n)
    51.9(a)
      426010  XM_004950820.1  XP_004950877.1 
    lizard
    (Anolis carolinensis)
    Reptilia GMIP6
    GEM interacting protein
    52(a)
    1 ↔ 1
    GL343198.1(3884917-3993214)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gmip1 GEM interacting protein 54.63(n)
    48.78(a)
      448355  NM_001004948.1  NP_001004948.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5658011 GEM-interacting protein-like 53.12(n)
    44.15(a)
      565801  XM_689070.5  XP_694162.5 
    worm
    (Caenorhabditis elegans)
    Secernentea spv-16
    Protein TAG-341, isoform a
    20(a)
    1 → many
    II(7912766-7928655) WBGene00014051
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BAG7(YOR134W)4 Rho GTPase activating protein (RhoGAP), stimulates more   --   15(578564-579793) 854302  NP_014777.1 


    ENSEMBL Gene Tree for GMIP (if available)
    TreeFam Gene Tree for GMIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GMIP gene
    ARHGAP292  HMHA12  ARHGAP192  ARHGAP19-SLIT12  
    5 SIMAP similar genes for GMIP using alignment to 6 protein entries:     GMIP_HUMAN (see all proteins):
    ARHGAP29    ARHGAP21    CHN2    HMHA1    ARHGAP12

    Find genes that share paralogs with GMIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GMIP (see all 382)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998611081,2
    C--19741058(+) TCACAC/TCGCCC 2 D G mis11Minor allele frequency- T:0.00EU 1061
    rs2019579951,2
    C--19741059(+) CACACC/TGCCCC 2 S G mis10--------
    rs349605561,2
    C,F--19741070(+) GGGGAT/AACTTC 2 /Y /F mis13Minor allele frequency- A:0.01NA WA 3636
    rs1852098281,2
    C--19741131(+) CTCTGA/GGCCTT 2 P S mis10--------
    rs1117212901,2
    C--19741160(+) GGGTGT/GGTGGT 1 -- int11Minor allele frequency- G:0.33CSA 3
    rs2013782191,2
    C--19741176(+) CAGAGC/TACCTC 1 -- int10--------
    rs2007168431,2
    C--19741198(+) TATATC/GCCCCA 1 -- int11Minor allele frequency- G:0.00EU 957
    rs1998793531,2
    --19741251(+) CCAGAA/GCTCCT 1 -- int10--------
    rs1388163761,2
    C,F--19741292(+) TCCCCC/GATCTT 2 R G mis12Minor allele frequency- G:0.01NA EU 5873
    rs355409981,2
    C,F,H--19741311(+) TCAGCC/TACGTC 2 V syn15Minor allele frequency- T:0.00NA NS 4726

    HapMap Linkage Disequilibrium report for GMIP (19740285 - 19754476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GMIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509725CNV Insertion20534489
    nsv911310CNV Loss21882294
    nsv911309CNV Loss21882294

    Human Gene Mutation Database (HGMD): GMIP
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GMIP
    DNA2.0 Custom Variant and Variant Library Synthesis for GMIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609694    OMIM disorders: --


    Find genes that share disorders with GMIP           About GenesLikeMe

    Genetic Association Database (GAD): GMIP
    Human Genome Epidemiology (HuGE) Navigator: GMIP (5 documents)

    Export disorders for GMIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GMIP gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with GMIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Gem interacting protein (GMIP) gene is associated with major depressive disorder. (PubMed id 16086184)1, 3, 4, 9 Tadokoro K....Kunugi H. (Neurogenetics 2005)
    2. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. (PubMed id 12093360)1, 2, 3 Aresta S.... de Gunzburg J. (Biochem. J. 2002)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    5. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. (PubMed id 22438581)1 Johnson J.L....Catz S.D. (Mol. Biol. Cell 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Poor replication of candidate genes for major depressive disorder using genome-wide association data. (PubMed id 20351714)1 Bosker F.J....Nolen W.A. (Mol. Psychiatry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51291 HGNC: 24852 AceView: GMIP Ensembl:ENSG00000089639 euGenes: HUgn51291
    ECgene: GMIP H-InvDB: GMIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GMIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GMIP gene:
    Search GeneIP for patents involving GMIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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